"""trial"".""trial_id"""	"""trial"".""public_title"""	"""trial"".""recruitment_status"""	"""trial"".""study_type"""	"""trial"".""date_registration"""	"""trial"".""last_refreshed"""	"""trial"".""source_register"""	"""trial"".""id"""	"""trial"".""scientific_title"""	"""trial"".""scientific_title_native"""	"""trial"".""study_design"""	"""trial"".""study_phase"""	"""trial"".""allocation"""	"""trial"".""masking"""	"""trial"".""purpose"""	"""trial"".""date_enrolment"""	"""trial"".""primary_sponsor"""	"""trial"".""secondary_sponsors"""	"""trial"".""web_address"""	"""trial"".""target_size"""	"""trial"".""inclusion_criteria"""	"""trial"".""exclusion_criteria"""	"""trial"".""health_conditions"""	"""trial"".""interventions_summary"""	"""trial"".""contacts_summary"""	"""trial"".""results"""	"""trial"".""countries"""	"""trial"".""updated_on"""
RBR-5rmxgnb	&quot;Comparing the Well-being of Physicians  Network-Based Medical Residency of the Department of Public Health of the City of São Paulo and of Irmandade da Santa Casa de Misericórdia de São Paulo&quot;	Not yet recruiting	Observational	2023-07-12	<NULL>	<NULL>	6230	Comparative Study on the Well-being of Resident Physicians of the Network-Based Medical Residency of the Department of Public Health of the City of São Paulo and of Irmandade da Santa Casa de Misericórdia de São Paulo	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5rmxgnb	<NULL>	Resident physicians ; both sexes ; between 18 and 60 years old ; agree to participate in the study	Non-agreement to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-4q5wsz	&quot;Effect of a muscle strengthening program in neural functions and in emotional state of elderly with mild cognitive impairment&quot;	Recruitment completed	Intervention	2017-01-02	<NULL>	<NULL>	1130	&quot;Effect of a home-based muscle strengthening program on cognitive function and affective state of community-dwelling elderly with mild cognitive impairment&quot;	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4q5wsz	<NULL>	Older adults with 60 years or more; community-dwelling residents; able to walk with and without ai; mild cognitive impairment.	Illiteracy; visual and/or auditory deficit; descompensated clinical conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-65frmbm	&quot;Effects of Brain Stimulation as Therapeutic Support in Body Control Issues in Individuals with Brain Differences: a Randomized Study&quot;	Not yet recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8581	Effects of using Transcranial Direct Current Stimulation as a therapeutic support tool in Autonomic Dysfunction in Neurodivergent individuals: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-30	Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco	<NULL>	<NULL>	<NULL>	Patients treated at the neuromodulation clinic located at the IFPE Campus Pesqueira, referred by the Association of People with Special Rights (PODE), the Psychosocial Care Center (CAPS), and the Basic Health Unit (UBS), all located in the city of Pesqueira-PE, with neurological reports indicating autism spectrum disorder, attention deficit hyperactivity disorder, and other neurodivergences.	Participants with epilepsy, those using anticonvulsant medications and/or suffering from sleep deprivation, patients with metallic implants in or near the head (e.g. cochlear implant, implanted electrodes/stimulators, aneurysm clips or coils, projectile fragments, jewelry, and hair clips), patients with cardiac pacemakers, stents, or other active devices whose interaction with the electric field may interfere with their functioning, patients with eczema on the head, patients with inconclusive diagnostic outcomes, therapy abandonment, and hospitalization	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-539d97	&quot;Modifications in patients with subacute or chronic mechanical neck pain after osteopathic treatment and conventional physiotherapeutic treatment&quot;	Not yet recruiting	Intervention	2019-07-10	<NULL>	<NULL>	2813	&quot;Modifications in patients with subacute or chronic mechanical neck pain after osteopathic treatment and conventional physiotherapeutic treatment&quot;	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Fisioclinic	Fisioclinic	https://ensaiosclinicos.gov.br/rg/RBR-539d97	<NULL>	Patients with symptoms of cervical pain, diagnosed with subacute or chronic mechanical neck pain;Chronic mechanical neck pain (CMC);Patients with limitation in the opening of the mouth of less than 40mm, without the need to suffer symptoms in the ATM; Whole age (between 18 and 50 years old);With signed written consent;No difference of sex;Patients dysfunction or disorders in the high cervical	Any surgical intervention in upper limbs, head or spine at any time of their lives;Having received previous osteopathic treatment in the last two months;Having received medical treatment two weeks before the study;Refusal of the patient to participate in the study;Any Contraindication to the application of the treatment or evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-5km45m	&quot;Teaching of foot care&quot; in people with Diabetes Mellitus type 2: a randomized clinical trial	Recruitment completed	Intervention	2019-04-30	<NULL>	<NULL>	2642	&quot;Teaching of foot care&quot; in reducing the risk of integrity of harmful skin of people with Diabetes Mellitus type 2: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-10	Universidade Federal de Alfenas	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5km45m	<NULL>	Target sample size is 168 people with Type 2 Diabetes Mellitus; diagnosed for at least five years; registered in the Health Information System for Primary Care (SIAB); with a minimum age of eighteen years and maximum age not stipulated and of both genders.	Persons with T2DM who present active ulcers or lower limb amputations; deficits in cognitive ability, identified by the Mental State Mini-Exam (MMSE), and those who do not want or can not participate in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-287qk4	(Con) Living with carpal tunnel syndrome severe degree: patients´report	Not yet recruiting	Intervention	2017-01-06	<NULL>	<NULL>	1170	(Con) Living with carpal tunnel syndrome severe degree: everyday narratives	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-287qk4	<NULL>	People of both sexes, medical diagnosis of carpal tunnel syndrome; test electromyography to report to carpal tunnel syndrome severe degree; pain and symptoms present for at least six months and positivity for the Phalen and Tinel tests.	History of trauma or previous surgery in the dominant upper limb or spine; subluxation of acromioclavicular and glenohumeral joint; osteoarthritis of joint complex of the elbow, wrist and hand; tendinopathy in joint complex of elbow, wrist and hand; diagnosis of rheumatic, degenerative or neurological disease; physical therapy and/or occupational therapy or use of orthosis in the last three months before entering the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-79d5xqg	".
Effect of bergamot orange oil on elderly sleep quality"	Recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9104	Effect of Aromatherapy with Citrus Bergamia essential oil on the sleep quality of elderly people: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Alfenas-MG	<NULL>	<NULL>	<NULL>	Individuals of both sexes, aged over 60, including current and retired employees of the Federal University of Alfenas; and the general public; who have sleep disturbances as indicated by a Pittsburgh Sleep Quality Index (PSQI) score of ≥5	Using other integrative practices to improve sleep quality; having an allergy or intolerance to strong odors;having skin irritation or lesions on the face; having a known history of respiratory disorders, such as asthma	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-45hth2d	.Effect of resistance training to improve physical capacity in people with chronic low back pain	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5176	Influence of a resistance training program for people with chronic low back pain on parameters associated with functional disability, pain and neuromuscular activation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Faculdade de Educação Física da ACM de Sorocaba	Faculdade de Educação Física da ACM de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-45hth2d	<NULL>	Time of low back pain between three and twelve months; episodes of pain at least twice a week; pain scale not exceeding five points; oswestry desability between twenty one and forty; no pain below the knee; not having a positive test for radicular pain in the lower limbs; agree not to use medications or pain relievers during the study; not participating in any exercise program for at least three months; men or women aged between twenty and fifty nine years; absence of spinal surgery, herniated disc or severe scoliosis; body mass index less than thirty; present an image exam of orthostatic or resonance radiography; not being involved in labor proceedings.	Participation in less than seventy five percent of training sessions; impossibility to carry out the final evaluation; use any medication or pain relievers during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-107m2sgt	10 years of nutritional health records from the teaching clinics of the Brazilian Institute of Rehabilitation Medicine, Rio de Janeiro	Not yet recruiting	Observational	2025-01-06	<NULL>	<NULL>	7639	Retrospective analysis of 10 years of nutritional records in the teaching clinics of the IBMR University Center, Rio de Janeiro	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-10	Instituto Brasileiro de Medicina de Reabilitação	Instituto Brasileiro de Medicina de Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-107m2sgt	<NULL>	Medical records of patients treated at the Teaching Clinics of the Brazilian Institute of Medicine and Rehabilitation (IBMR) University Center in Rio de Janeiro during the period from January 2014 to December 2024. Records must contain complete and up-to-date information on diagnoses, treatments, and clinical progress, with detailed documentation of nutrition-related health conditions, specifically hypertension, diabetes, obesity, malnutrition, and eating disorders. Records of patients treated at all units of the Teaching Clinics, regardless of gender, age, or ethnicity, provided they meet the other established criteria	Medical records with incomplete or illegible information, hindering the extraction and analysis of the data necessary for the research. Records of patients whose care occurred outside the period of interest, that is, before January 2014 or after December 2024. Records related to emergency or specific care that do not allow for a comprehensive analysis of nutrition-related health conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-9qwppm	3D Changes Associated with Surgically Assisted Rapid Palatal Expansion (SARPE): Cranial Base Overprint	Data analysis completed	Intervention	2019-12-04	<NULL>	<NULL>	3247	Surgically assisted rapid maxillary expansion (ERMAC): dental and skeletal effects assessed by cone-beam computed tomography	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade de São Paulo (USP)	Universidade de São Paulo (USP)	https://ensaiosclinicos.gov.br/rg/RBR-9qwppm	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 60 years; weight within the range of 15% of the weight considered normal for men and women, taking into account the height and physical structure, which have transverse maxillary deficiency and broad oral corridors.	Volunteers with untreated periodontal disease and / or caries lesions; systemic diseases; use of drugs that may alter bone metabolism; mechanical complications of the expanders and absence of CBCT images.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8x8pf6d	3D digital analysis of dental arches before and after surgery in patients with unilateral and bilateral cleft lip and palate	Data analysis completed	Observational	2023-06-30	<NULL>	<NULL>	6192	Use of 3D Sterephotogrammetry for volumetric analysis and image superimposition of the dental arches before and after surgeries in patients with unilateral and bilateral cleft lip and palate	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8x8pf6d	<NULL>	Participants with non-syndromic unilateral cleft lip and palate; all surgical procedures were performed by a single plastic surgeon; male and female genders	Poor quality dental models	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-5zcggj	3D glasses may improve adherence to treatment in Glaucoma patients that use only one eyedrop. A clinical study.	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2681	3D virtual reality may enhance adherence in glaucoma patients using monotherapy - a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-04-10	HCloe Clinica Oftalmológica Especializada	HCloe Clinica Oftalmológica Especializada	https://ensaiosclinicos.gov.br/rg/RBR-5zcggj	<NULL>	We included glaucoma patients with age equal to or above 18; who were already being treated at our clinics; with the minimal visual acuity 20/40 according to the Snellen table	The exclusion criteria included an age of fewer than 18-years-old; the demand for surgery during the three-month evaluation period; corneal diseases that interfered with the accurate measurement of intraocular pressure (IOP);  retinal diseases that impeded the quality of an optical tomography coherence exam (OCT) and computer perimetry.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-9rjg3g	5-fluorouracil 5% compared to vitamin b3 in the treatment of precancerous skin changes	Recruiting	Intervention	2016-11-24	<NULL>	<NULL>	1077	5- fluorouracil 5% intermittent versus nicotinamide at the treatment cancerization skin field: a clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-26	Faculdade de Medicina de Botucatu - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9rjg3g	<NULL>	Age above 18 years of both sexes; provide at least three and no more than ten clinically compatible with actinic keratosis lesions on each forearm bilaterally.	Selected treatment area that has atypical clinical appearance or other extensive dermatoses forearms; current and previous clinical diagnosis or evidence of any medical condition that expose the patient to increased risk, interfere with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances under study; use of topical or systemic immunosuppressive substance, oral retinoid, and other local treatments (eg corticosteroids, anti-inflammatories, retinoids); immunocompromised; pregnancy suspected or confirmed; women of childbearing potential not using contraception; women in breastfeeding; coagulation disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-3kcsy25	8-week Mindfulness Based Taining for parents of children with Autism and impact assesment on indices of Anxiety, Stress, Depression, Life Satisfaction, and Mindfulness	Recruitment completed	Intervention	2024-12-16	<NULL>	<NULL>	7598	8-week Mindfulness Based Taining for parents of children with Autism Spectrum Disorder and impact assesment on indices of Anxiety, Stress, Depression, Life Satisfaction, and Mindfulness	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3kcsy25	<NULL>	Be parents of children between 5 months and 14 years of age who have a diagnosis of autism spectrum disorder established according to the DSM-V criteria. Accept and be available to participate in one of the 2 mindfulness intervention groups for 8 weeks (8 meetings of approximately 2 hours) to be held online via the Zoom platform. Agree to complete the pre- and post-intervention questionnaires, as well as the Informed Consent Form (TCLE - Termo de Consentimento Livre e Esclarecido) and a health screening questionnaire.	Patients who are unable to attend online sessions at the scheduled times, either due to lack of availability or adequate equipment (computer with webcam, headphones, microphone, and broadband internet). Patients with more than 2 absences from the program or who miss the first or second session of the program. Participants with a diagnosis of a serious illness such as cancer, epilepsy. Participants with a diagnosis of an uncontrolled psychiatric disorder: schizophrenia, bipolar disorder, severe depression.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-8d8rj7	"90/5000
Different devices to interact with virtual environment in people with Multiple Sclerosis"	Recruiting	Intervention	2018-06-28	<NULL>	<NULL>	1941	"Analysis of different interaction devices during a Timing Task
Coincident in virtual environment in people with Multiple Sclerosis"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-19	Universidade  de São Paulo	Associação Brasileira de Esclerose Múltipla	https://ensaiosclinicos.gov.br/rg/RBR-8d8rj7	<NULL>	Multiple Sclerosis diagnosis of recurrent remitting type	Changes in motor functions and pain in the dominant upper limb; during or up to one month prior to data collect	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-2fqcbrx	A  study to evaluate the efficacy of Eclipta prostrata (L.) L. in the treatment of atopic dermatitis in children	Not yet recruiting	Intervention	2022-12-16	<NULL>	<NULL>	5766	A double-blind, randomized, placebo-controlled study to evaluate the efficacy of Eclipta prostrata (L.) L. in the treatment of atopic dermatitis in children above 2 years old	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-01-09	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - USP	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FAEPA)	https://ensaiosclinicos.gov.br/rg/RBR-2fqcbrx	<NULL>	Children and adolescents between 2 and 18 years old; clinical diagnosis of atopic dermatitis, according to the Hanifin and Rajka criteria	Diagnosis or presence of acute or chronic cutaneous diseases, not suggestive of atopic dermatitis, that may interfere with the study results; use of corticosteroids, systemic immunosuppressants or immunobiologicals for at least 30 days before or during participation in the study; allergy or serious adverse events attributable to the administration of the investigational product; non-adherence to treatment (ie, not using the investigational product regularly, as prescribed) for at least one continuous month; failure to attend more than 50% of the evaluations (clinical and/or laboratory) that will be carried out during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-5d758t9	A Clinical Study for Safety and Immunogenicity Increment after Extra Dose with Chadox1-S/NCOV-19 or third dose of Coronavac in previously Vaccinated Elderly subjects	Not yet recruiting	Intervention	2021-09-15	<NULL>	<NULL>	4889	A Randomized, Patient-Single-Blind Phase IV Clinical Study for Assessing the Safety and Laboratory Immunogenicity Increment after Vaccine Booster with Chadox1-S/NCOV-19 or third dose of Coronavac in previously Vaccinated Elderly subjects	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-09-18	Instituto do Câncer Brasil (unidade Ribeirão Preto)	Instituto do Câncer Brasil (unidade Ribeirão Preto)	https://ensaiosclinicos.gov.br/rg/RBR-5d758t9	<NULL>	Male or female participants; aged 60 years or older; previously vaccinated with CoronaVac; Have previously received 2 doses of CoronaVac, as per the national immunization plan; the second dose administered at least 30 days ago.	Have had Covid-19 after the start of the vaccination schedule with CoronaVac; Symptoms of infection of any organ or etiology in the last 30 days, as per investigator’s judgment; Have had contact with an individual diagnosed with COVID-19 in the work or home environment in the last 10 days;Subjects with AIDS, severe immunosuppression or patients with a severe disease, as per investigator’s judgment.Have a Karnofsky Performance status below or lower than 70 (Attachment A). Known allergy to the components of the vaccines used in the study. Participation in another clinical study in less than 1 year (unless participation is justifiable as per the principal investigator).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-78jvzx	A clinical study of non-invasive brain stimulation in unilateral spatial neglect after stroke	Recruitment completed	Intervention	2016-05-03	<NULL>	<NULL>	5000	Effect of transcranial electric stimulation in unilateral spatial neglect after Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Hospital das Clínicas da Faculdade de Medicina de Botucatu	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78jvzx	<NULL>	Patients will eligible for inclusion in the trial if they will aged at least 18 years and had USN after ischemic stroke diagnosis within six months of the start of stroke symptoms (subacute phase). Ischemic stroke will be confirm using computed tomography (CT) or magnetic resonance imaging (MRI), and USN will objectively diagnosed using conventional Behavior Inattention Tasks (BIT-C) with a cutoff value of &lt;129.	Individuals will excluded if they will suffer hemorrhagic stroke, metal-in-cranium injuries near the electrode placement area, intracerebral vascular clips or any other electrically sensitive support system, clinical instability, epilepsy, severe cognitive impairment, bilateral lesions, global aphasia, previous visual disturbances, pregnancy, or other neurological diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-2hqhdp	A clinical study to assess the durability dental restorations made with bioactive restorative materials: a randomized clinical trial	Recruiting	Intervention	2018-11-06	<NULL>	<NULL>	2315	Longevity of class II restorations performed with bioactive restorative materials: a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-08-15	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - ICT UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2hqhdp	<NULL>	Patients 12 to 50 years old able to provide valid information; who require at least one class II dental restoration due to active carious lesion or exchange for poor permanent tooth restoration; the tooth selected to receive the restoration must have an antagonist and adjacent tooth; without excessive tooth wear; without evident temporomandibular disorders.	Start orthodontics during the course of the research; present allergy to any material used in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-8vvwj8	A clinical study to evaluate the efficacy and safety of Ambrisentan on Pulmonary Arterial Hypertension in patients aged 8 years up to 18 years	Suspended	Intervention	2016-07-05	<NULL>	<NULL>	907	AMB112529 - A randomized, open label study comparing safety and efficacy parameters for a high and a low dose of Ambrisentan (adjusted for body weight) for the treatment of Pulmonary Arterial Hypertension in paediatric patients aged 8 years up to 18 years	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2011-01-04	GlaxoSmithKline	GlaxoSmithKline	https://ensaiosclinicos.gov.br/rg/RBR-8vvwj8	<NULL>	66 Volunteers with diagnosis of Persistent  Pulmonary Arterial Hypertension;  Male or female; at least 8 years of age and not yet 18 years of age	Volunteers currently taking an endothelin receptor antagonist or cyclosporine A and whose body weight is less than 20 Kg	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-3t7fcy	A clinical study to evaluate the safety and blood concentration of melatonin nasal suspension in healthy male research participants.	Not yet recruiting	Intervention	2017-10-31	<NULL>	<NULL>	1517	A randomized, double-blind, monocentric, phase I clinical trial to assess the tolerability, safety, and pharmacokinetics of melatonin nasal suspension, after a single dose in healthy male participants.	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2017-12-21	Cosmed Indústria de Cosméticos e Medicamentos S.A.	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-3t7fcy	<NULL>	Healthy research participants; male gender; age equal to 18 and less than or equal to 35 years; body weight greater than or equal to 50 kg and BMI less than or equal to 30 kg / m2.	Research participants with complementary examinations outside normal values; history of excessive alcohol consumption; history of psychotropic drug use; be non-tolerant to the nasal spray test; history of upper or lower respiratory tract infection (1 month prior to study participation).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8hc3zf	A clinical study to evaluate the safety and blood concentration of Melatonin sublingual in healthy male research participants	Not yet recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1960	A randomized, double-blind, monocentric, phase I clinical trial to assess the tolerability, safety, and pharmacokinetics of Melatonin Sublingual Suspension, after a single dose in healthy male participants	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-09-10	Instituto de Ciências Farmacêuticas	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-8hc3zf	<NULL>	Healthy research participants; male gender; age equal to 18 and less than or equal to 35 years; body weight greater than or equal to 50Kg and BMI less than or equal to 30Kg/m2.	Research participants with complementary examinations outside normal values; history of excessive alcohol consumption; history of psychotropic drug use; have participated in any experimental drug study within 1 year before starting the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-6sz8zht	A clinical study to investigate the effects of oral immunonutrients during the perioperative period of patients with gastrointestinal cancer	Not yet recruiting	Intervention	2024-05-10	<NULL>	<NULL>	7000	Effects of enteral supplementation with immunonutrients in the perioperative course of patients with cancer of the gastrointestinal tract: A double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-6sz8zht	<NULL>	Patients aged over 18 years will be included; with anatomopathological examination that shows any histological type of cancer of the gastrointestinal tract; who will undergo any curative and elective surgical procedure	Pregnant women will be excluded; people submitted to the use of artificial nutrition in the 15 days prior to inclusion in the study; people allergic to any components of the diet; people with any gastrointestinal diseases prior to the malignancy; people with immunosuppression or using immunosuppressive therapies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-4hm9bf	A clinical trial investigating the anti-virus effects, kinetics and safety of GS-5806 in adults with RSV (respiratory syncytial virus) infection	Not yet recruiting	Intervention	2016-03-10	<NULL>	<NULL>	744	A phase 2b, randomized, double-blind, placebo controlled multi-center study evaluating antiviral effects, pharmacokinetics, safety, and tolerability of GS-5806 in hematopoietic cell transplant (HCT) recipients with respiratory syncytial virus (RSV) infection of the upper respiratory tract	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2015-07-01	Fundação Doutor Amaral Carvalho	Pharmaceutical Research Associates Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-4hm9bf	<NULL>	Received an autologous or allogeneic hematopoietic cell transplantation (HCT) using any conditioning regimen; Documented to be RSV-positive (respiratory syncytial virus) as determined by local testing for example, PCR (polymerase chain reaction), DFA (direct fluorescent antibody), RVP (respiratory virus pannel) assay, or culture using an upper respiratory tract sample collected 6 days or less prior to Day 1; New onset of at least 1 of the following respiratory symptoms for 7 days or less prior to Day 1: nasal congestion, runny nose, cough, or sore throat, or worsening of one of these chronic respiratory symptoms 7 days or less prior to Day 1; No evidence of new abnormalities consistent with LRTI on a chest X-ray relative to the most recent chest X-ray, as determined by the local radiologist. If a chest X-ray is not available or was not obtained during standard care 48 hours or less prior to Screening, a chest X-ray must be obtained for Screening; O2 saturation equal or higher than 92% on room air; An informed consent document signed and dated by the subject or a legal guardian of the subject and the investigator or his or her designee; A negative urine or serum pregnancy test is required for female subjects, unless surgically sterile or greater than two years post-menopausal; Male and female subjects of childbearing potential must agree to contraceptive requirements as described in Appendix 5; Willingness to complete necessary study procedures and have available a working telephone or email.	Related to concomitant or previous medication use: Use of non-marketed according to region investigational agents within 30 days, OR use of any monoclonal anti-RSV antibodies within 4 months or 5 half-lives of Screening, whicheveris longer, OR use of any investigational RSV vaccines after HCT; Use of a strong cytochrome P450 enzyme inducer including but not limited to rifampin, St. John’s Wort, carbamazepine, and phenytoin, within 2 weeks prior to the first dose of IMP; Related to medical history: Admitted to the hospital primarily for a lower respiratory tract disease of any cause as determined by the investigator; Pregnant, reastfeeding, or lactating females; Unable to tolerate nasal sampling required for this study, as determined by the investigator; Known history of HIV and or AIDS with a CD4 count &lt;200 cells/microL within the last month; History of drug and/or alcohol abuse that, in the opinion of the investigator, may prevent adherence to study activities; Related to medical condition at Screening: A relapse, including molecular relapse, of the underlying disease for which they received a transplant at Screening; Documented to be positive for other respiratory viruses limited to influenza, parainfluenza, human rhinovirus, adenovirus, or human metapneumovirus within 7 days prior to the Screening visit, as determined by local testing; Clinically significant bacteremia or fungemia within 7 days prior to Screening that has not been adequately treated, as determined by the investigator; Clinically significant bacterial, fungal, or viral pneumonia within 2 weeks prior to Screening that has not been adequately treated, as determined by the investigator; Excessive nausea/vomiting at Screening, as determined by the investigator, or an inability to swallow pills that precludes oral administration of the IMP; Any condition which, in the opinion of the investigator, would prevent full participation in this trial or would interfere with the evaluation of the trial endpoints; Related to allergies: Known hypersensitivity or allergy to the IMP, its metabolites, or formulation excipients like microcrystalline cellulose, mannitol, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol and talc; Allergy to sulfa drugs; Related to laboratory results: Creatinine clearance lesser than 30 mL/min, calculated using the Cockcroft-Gault method; AST/ALT higher than 3x ULN; Total bilirubin higher than 3x ULN.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-3gz8hc	A Clinical Trial of Spectrila® in Adult Subjects with Newly Diagnosed Acute Lymphoblastic Leukaemia	Not yet recruiting	Intervention	2017-09-20	<NULL>	<NULL>	1392	"A Clinical Phase II Trial to Describe Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of Spectrila® with the
Pharmaceutical Active Ingredient Recombinant L-Asparaginase in Adult Subjects with Newly Diagnosed Acute B-Cell Lymphoblastic Leukaemia"	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-12-15	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3gz8hc	<NULL>	Subjects with newly diagnosed pathologically confirmed acute B-cell lymphoblastic leukaemia; Female or male higher or equal to 18 years of age; Eligible for treatment and treated according to the underlying treatment protocol BRALL 2014; Written informed consent given freely; Subject expresses his/her understanding of the trial procedures and willingness to abide by them during the course of the trial; Female subjects of child-bearing potential must use a highly effective method of contraception (pearl index less than 1%)  in combination with a second method of contraception during the trial and for at least 3 months after Spectrila discontinuation; Men should use effective contraceptive measures and be advised to not father a child while receiving ASNase.	"Pre-treatment with any ASNase preparation; 
Hypersensitivity to the active substance, Escherichia coli-ASNase preparation or to any of the excipients; Pancreatitis at the time of treatment initiation or history of pancreatitis; Pre-existing known coagulopathy; Severe liver function impairment; History of serious haemorrhage or serious thrombosis; Other current malignancies; Uncontrolled active infection; Evidence of infection with the human immunodeficiency virus, hepatitis B or C, human T-lymphotropic virus type I and
II, syphilis or Chagas disease (American trypanosomiasis); Pregnancy as verified by a positive pregnancy test or nursing woman; Active psychiatric or mental illness making informed consent or careful clinical follow-up unlikely; Evidence or suspicion that the subject might not comply with the requirements of the trial protocol; Evidence or suspicion that the subject is unwilling or unable to
understand the information given to him/her within the informed consent procedure; Any other factor which in the investigator’s opinion is likely to compromise the subject’s ability to participate in the trial; The subject is an employee or direct relative of an employee of the contract research organisation (CRO) involved in the trial,
the trial site or medac; The subject is imprisoned or is lawfully kept in an institution; The subject has participated within 3 months before screening or plans to participate in a clinical trial (except the underlying treatment protocol BRALL 2014); Previous participation in this clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-3k58mg	A clinical trial to compare the results of blood bioindicators using a non-invasive medical device with those from the routine laboratory tests	Terminated	Intervention	2020-05-26	<NULL>	<NULL>	4585	A comparative clinical trial for the viability of a medical device	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-07-21	Nanotimize Tecnologia S.A	CAEP - Centro Avançado de Estudos e Pesquisas	https://ensaiosclinicos.gov.br/rg/RBR-3k58mg	<NULL>	Men or women aged between 18 and 55 years-old; being able to sign the ICF approved by IRB and to execute and understand all study procedures and instructions	Subjects who do not agree to participate in the clinical trial and do not sign the ICF	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-5pygzhj	A clinical trial to evaluate the feasibility and efficacy of using Anastrozole before surgery for patients with hormone-related localized Breast Cancer with low proliferative capacity	Recruiting	Intervention	2022-07-18	<NULL>	<NULL>	6414	A phase II single-arm clinical trial to evaluate the feasibility and efficacy of Neoadjuvant Anastrozole in luminal, low proliferative index Breast Cancer patients at TNM stages II and III	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2022-07-20	Hospital de Câncer de Barretos	Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-5pygzhj	<NULL>	"Age 18 years or older; histologically confirmed unilateral primary invasive carcinoma of the breast; 
estrogen receptor positive (Allread ≥6); progesterone receptor positive (any percentage value); HER-2 negative; histological grade according to Scarf-Bloom-Richardson 1 or 2; Ki-67 antigen &lt;50% on immunohistochemistry; TNM staging by 8th Edition cT2-4c cNqq M0; tumor clinically palpable and larger than 2cm on palpation and/or imaging examination; functional capacity assessed by Eastern Cooperative Oncology Group Performance Status (ECOG-PS) of 0 - 2; adequate hematologic, renal, and hepatic function; absence of any psychological, familial, sociological, or geographic condition that would potentially hinder adherence to the study protocol and follow-up schedule; patient agreeent to provide the required research biopsies from baseline, week 4 (re-biopsy) and surgery for biomarker and biorepository research."	Inflammatory breast cancer defined as clinically significant erythema of the breast and/or documented dermal lymphatic invasion; excisional biopsy of current breast cancer; hormone replacement therapy of any kind, megestrol acetate or raloxifene within one week prior to inclusion; axillary staging surgical procedure prior to study entry; clinical or radiographic evidence of metastatic disease; skin implants in the breast that prevent the required research biopsies or may interfere with palpation of the breast lesion; treatment for cancer, including surgery, radiation therapy, chemotherapy, biotherapy, hormone therapy, or any investigational product prior to study entry; history of previous invasive breast cancer; patient with any other concomitant serious and/or uncontrolled medical condition that may, in the opinion of the Investigator, cause unacceptable safety risks, contraindicate the patient&apos;s participation in the clinical trial or compromise adherence to the protocol (e.g. chronic pancreatitis, chronic active hepatitis, liver cirrhosis or any other significant liver disease, active, untreated or uncontrolled fungal, bacterial or viral infections, active infection requiring systemic antibacterial therapy, etc.) or limit life expectancy to ≤ 5 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-6pmz49	A clinical trial using Fluoxetine in patients with Premenstrual Syndrome	Recruiting	Intervention	2017-11-17	<NULL>	<NULL>	1485	"A translational approach of the neurobiological determinants of Premenstrual Syndrome
A clinical trial using Fluoxetine in patients with Premenstrual Syndrome"	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2017-05-01	Hospital das Clínicas de Ribeirão Preto	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FAEPA)	https://ensaiosclinicos.gov.br/rg/RBR-6pmz49	<NULL>	Non pregnant women; 18 to 40 years; fill retrospectivily the criteria for premenstrual syndrome according to the American College of Obstetricians and Gynecology	Continuous use of oral contraceptive or brake between pills less than 7 days; current use of injectable contraceptive (monthly or quarterly); current use of contraceptive implants;  current use of drosperinone; use of hormonal DIU; current daily use of benzodiazepines;  current use of drug or any substance which could interfere with esteroidal and/ or fluoxetine&apos;s metabolism;  currency major depressive episode, current generality anxiety, bipolar disorder, schizophrenia or other psychotic disorders, current obsessive-compulsive disorder, current postraumatic stress disorder, current use of ilicit drugs or alcohol (except current use of tobacco);  mild or severe intelectual disability; migraine (except the headache which occurs only in the premenstrual days); epilepsy; pregnancy; women who are breastfeeding; history of intolerance or severe side effects to fluoxetine; history or current other medical condition which could threaten the volunteer&apos;s safety during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-7hzhwd	A clinical, double-blind, randomized study to assess the effects and safety of Ivermectin in patients with Severe Acute Respiratory Syndrome during the Covid-19 pandemic	Terminated	Intervention	2020-05-20	<NULL>	<NULL>	5033	A phase IIb, double blind and randomized controlled study to evaluate the efficacy and safety of the Ivermectin in patients with Serious Acute Respiratory Syndrome during the Covid-19 pandemic	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-05-01	Hospital de Base de São José do Rio Preto	Faculdade de Medicina de São Jose do Rio Preto FAMERP	https://ensaiosclinicos.gov.br/rg/RBR-7hzhwd	<NULL>	"Men or women, 18 years of age or older, ability to provide informed consent signed by study patient or legally acceptable representative
Respiratory sign or symptom, cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose, O2 saturation less than 93%, signs of cyanosis, nasal flaring, accessory muscle use, and dyspnea).
Need for oxygen support using a nasal catheter up to 6 l / min to keep SaO2 above 94% or SpO2 less than 94% in room air.  
Proven diagnosis of Covid-19 using a molecular diagnostic assay based on polymerase chain reaction.
Requires hospitalization in the ward.
Less than seven days after the first flu-like symptom."	"Suspected infections suggestive of fungal or bacterial etiologies.
Chronic hepatitis C infection in antiviral therapy.
Severely immunocompromised in the investigator&apos;s opinion (eg, differentiation cluster count 4+ [CD4 +]  less than 200 cells / mm3, absolute neutrophil count less than 750 / mm3, first chemotherapy cycle completed within 2 weeks prior to screening, history stem cell transplantation within the period of 1 year prior to screening, any history of solid ORG transplant).
Pregnant women, Category C 
Patients with a life expectancy of less than 30 days
Patients with meningitis or other disorders of the Central Nervous System that may affect the blood-brain barrier"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-3rywwg	A clinical, randomized study to evaluate the efficacy and safety of Naproxen compared to placebo in combination with Azithromycin or Levofloxacin in patients with Severe Acute Respiratory Syndrome during the Covid-19 pandemic	Recruiting	Intervention	2020-07-10	<NULL>	<NULL>	3996	A phase IIb, double-blind, randomized controlled trial to evaluate the efficacy and safety of Naproxen compared to placebo in combination with Azithromycin or Levofloxacin in patients with Severe Acute Respiratory Syndrome during the Covid-19 pandemic	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-06-01	Faculdade de Medicina de São Jose do Rio Preto - FUNFARME/FAMERP	Hospital de Base de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-3rywwg	<NULL>	"Men or women, 18 years of age or older
Ability to provide informed consent signed by study patient or legally acceptable representative
Requires ICU hospitalization.
Respiratory sign or symptom (cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose
Need for oxygen support using a nasal catheter up to 6 l / min to keep SaO2 above 94% or SpO2 &lt;94% in room air.
Bilateral infiltrate at Rx or signs suggestive of COVID-19 pneumonia on chest tomography;
Less than seven days after the first flu-like symptom."	"Need for oxygen support in a nasal catheter over 6 l / min to maintain SaO2 above 93% or signs of respiratory distress for more than 6 h;
Patient intubated and on mechanical ventilatory support;
Need for vasopressor or signs of shock;
Chronic renal failure or AKI Kdigo I or greater;
History of bleeding or recent peptic ulcer 6 months;
Suspected infections suggestive of fungal or bacterial etiologies;
Chronic hepatitis C infection in antiviral therapy;
Severely immunocompromised in the investigator&apos;s opinion (eg, differentiation cluster count 4+ [CD4 +] less than 200 cells / mm3, absolute neutrophil count less than 750 / mm3, first chemotherapy cycle completed in the 2 weeks prior to screening, history of stem cell transplantation within the period of 1 year prior to screening, any history of solid organ transplantation;
Pregnant women;
Patients with a life expectancy of less than 30 days"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-29x7rhy	A comparative study between a modified traditional transscleral cyclophotocoagulation technique and the current standard technique in eyes with refractory glaucoma	Data analysis completed	Intervention	2025-12-24	<NULL>	<NULL>	8682	A prospective, randomized, comparative, examiner-masked study comparing a modification of the traditional transscleral cyclophotocoagulation technique with slow coagulation in eyes with refractory glaucoma	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; patients of any gender; patients who have undergone previous surgical interventions for glaucoma or not (excluding cyclodestructive procedures); patients previously operated on for glaucoma who experienced failure of such procedure(s) and did not achieve target intraocular pressure under maximally tolerated medication at medical discretion; patients with other subtypes of glaucoma classified as refractory glaucoma, such as neovascular glaucoma, glaucoma in aphakic eyes, inflammatory glaucoma, glaucoma associated with corneal transplant, post-vitreoretinal surgery glaucoma (with or without silicone oil implant), post-traumatic glaucoma; patients with glaucoma in eyes with conjunctiva unsuitable for filtering surgeries; patients with absolute glaucoma and a history of pain associated with marked ocular hypertension	Pregnant patients; lactating patients; patients with unknown or non-glaucoma related vision loss/deficit in any eye; history of previous cyclodestructive surgery; patients with a history of corneal refractive surgery; glaucoma with active uveitis; patient&apos;s inability to return on scheduled dates; patient&apos;s refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-64f7rct	A comparative study between Cryosurgery and Conventional Surgery in Oral Lesion Blister treatments A comparative study between cryosurgery and conventional surgery in oral mucoceles treatments	Data analysis completed	Intervention	2020-12-29	<NULL>	<NULL>	4450	A comparative study between Cryosurgery and Conventional Surgery in Oral Mucoceles treatments	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2017-02-06	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-64f7rct	<NULL>	Patients of both sexes; with oral lesions clinically compatible with mucoceles; round well-circumscribed; bluish or transparent and with a history of local trauma	Patients treated with antimicrobials; analgesics or anti-inflammatories; with a history of any type of oral surgery for less than thirty days or with symptomatic oral lesions of any nature	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-3vcqt9	A comparative study between two surgeries for women with Stress Urinary Leakage: Minisling (Solyx) and Transobturator Sling (Obtryx II)	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1569	Randomized controlled trial between Minisling (Solyx) vs Transobturator Sling (Obtryx II) in women with Stress Urinary Incontinence (SUI)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Hospital da Mulher José Aristodemo Pinotti	Boston Scientific	https://ensaiosclinicos.gov.br/rg/RBR-3vcqt9	<NULL>	"Women with 18 years and/or older.
Positive cough stress test for SUI or positive findings of stress urinary incontinence at urodynamic study (UDS).
Post-voiding residue &lt; 100 ml or less 20% of total urinary volume
Maximum bladder capacity over 300 ml"	"Women with overactive bladder or recurrent UTI or previous urogynecological surgeries.
Previous pelvic radiotherapy. 
Presence of pelvic organ prolapse (POP) stage 2 and over.
Past or recent history of bladder lithiasis, inferior urinary fistula or diverticulum. 
Current use of anticoagulants.
Previous surgical history of foreign-body reaction like (eg. history of surgery with prosthetic complications)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-2n2gsw	A comparison between the effects of two substances for superficial anesthesia on human gums.	Data analysis completed	Intervention	2017-12-11	<NULL>	<NULL>	1515	Comparative analysis of the effectiveness of  EMLA®( Euthetic Misture of Local Anesthetic) (Prilocaine 2,5% and lidocaine 2,5%) and benzocaine 20% on topical anesthetic in human&apos;s gengival mucosa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-20	Instituto Leão Sampaio de Ensino Universitário Ltda	Instituto Leão Sampaio de Ensino Universitário Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2n2gsw	<NULL>	Healthy volunteers; not pregnant; non smokers; not infants; no history of allergies to local anesthetics; without chronic use of medications; with complete natural dentition and no reports of numbness in the face or oral cavity	Volunteers with chronic diseases; pregnant women; smoking; infants; with a history of allergy to the local anesthetic and changes in face and mouth sensitivity; volunteers who did not attend the second visit and who did not have the medical records completely filled	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-83c6y8	A cooldown phase after intense exercise can decrease the incidence of ventricular arrhythmias?	Data analysis completed	Intervention	2016-05-05	<NULL>	<NULL>	831	A cooldown phase after intense exercise can decrease the incidence of ventricular arrhythmias?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-05	Instituto Dante Pazzanese de Cardiologia	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-83c6y8	<NULL>	Any patient presenting complex ventricular arrhythmia in the stress phase of the exercise test.	Patients with cardiac implantable devices; incapacity to keep walking after exercise phase; atrial fibrillation or flutter; technical artifacts in the electrocardiogram.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-9bsr5n4	A Distance Rehabilitation Proposal for Women with Knee Arthrosis	Recruitment completed	Intervention	2024-09-27	<NULL>	<NULL>	7382	A proposal for Telerehabilitation of Women with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade de São Paulo	Faculdades Integrada de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-9bsr5n4	<NULL>	Women; aged between 55 and 85; with a self-reported medical diagnosis and X-ray examination of knee osteoarthritis; with internet access; via wifi or 3G to 5G connection on smartphone, tablet or computer; and who had no indication for knee joint replacement surgery	Women without a medical diagnosis of knee osteoarthritis; with a history of knee joint surgery or with an indication for joint replacement; who declared that they did not have access to the internet; had any cognitive dysfunction or declared any impediment to participating during the requested period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-8tw8y5	A double-blind controlled study of acute effects of Elastic Bandage on myofascial pain	Recruitment completed	Intervention	2020-08-04	<NULL>	<NULL>	4084	A double-blind, randomized, controlled, trial of acute effects of Kinesio Taping on Temporomandibular Disorders Myogenic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Tuiuti do Paraná	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8tw8y5	<NULL>	Volunters with diagnosis of myogenic TMD using the Research Diagnostic Criteria for Temporomandibular Disorders for 6 months or more; aged between 18 and 60 years of which only subjects up to 57 years old were found for both groups	Recent or old facial trauma, undergone treatment for Myogenic Temporomandibular Dysfunction in the last six months; use analgesic and or anti-inflammatory drugs in the last six months; using occlusal plaque; being under orthodontic treatment; presence of central or peripheral neurological disorders; having a diagnosis of systemic disease and a history of surgery and or tumors or trauma in the head and or neck region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-7fgjdxb	A double-blind randomized clinical evaluation of a bulk-fill resin composite in posterior restorations	Not yet recruiting	Intervention	2026-03-09	<NULL>	<NULL>	8954	Clinical evaluation of a fast and high-power curing bulk-fill resin composite in posterior restorations: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-03	Universidade Estadual de Ponta Grossa	<NULL>	<NULL>	<NULL>	Participants aged 18–70 years; participants clinically healthy; participants presenting at least 20 teeth in occlusion and an acceptable level of oral hygiene; each participant must require at least two Class I or II restorations in vital teeth with cavities of similar horizontal and vertical dimensions; the selected teeth must present functional occlusion with the natural antagonist tooth and proximal contact with adjacent teeth; pulp vitality will be confirmed by means of a thermal test using a cold spray and periapical radiography; a positive response will be considered when it occurs within 10 seconds after stimulus application and is characterized by mild, short-lasting pain, consistent with a vital pulp	Participants that present unsatisfactory oral hygiene characterized by a Simplified Oral Hygiene Index  greater than 3; participants diagnosed with chronic or advanced periodontitis, defined as probing depth greater than 4 mm, presence of bleeding on probing, participants with clinical attachment loss greater than 3 mm in more than four teeth; participants with fixed orthodontic appliances; participants that present significant occlusal wear in more than 10 posterior teeth; participants that require endodontic treatment; participants that presente hypersensitivity to resin-based composite materials or to any other materials used in this study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-5hgxy8	A double-blind randomized clinical trial applied to lower limb diabetic ulcers using a combination of biomembrane derived from natural latex (Hevea Brasiliensis) and  light emitting equipment	Not yet recruiting	Intervention	2018-12-05	<NULL>	<NULL>	2366	"Randomized double-blind clinical trial in diabetic ulcers of lower limbs using biomembrane association derived from natural latex
(Hevea Brasiliensis) and  light emitting equipment varied wavelength 450 to 636 nm"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade do Gama	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-5hgxy8	<NULL>	"Patients aged between 18 years and 75 years;
with history of diabetes mellitus type I or II; to present a single type A1 or A2 diabetic foot ulcer (University of Texas classification, with indication of outpatient treatment, without infection and without indication of surgical debridement, with a history of diabetic foot ulcer of more than 6 weeks duration and less of 12 months, have no allergy to latex, intellectually fit, have a cell phone with the ability to take photographs and have the application WhatsApp"	Diabetes mellitus uncontrolled with glycated Hb&gt; 10 g / dl; irregular use of medication for the disease or even without regular medical follow-up; evidence of osteomyelitis or gangrene at either end; have lesions with excessive exudate; be an active smoker, regular user of alcoholic beverages and / or illicit drugs; another chronic disease that at the discretion of the investigator compromises the participation in the study; pregnant or lactating women or women of child-bearing age without adequate contraception; participation in another clinical study in less than 1 year (unless justified by the researcher)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-8mwkyq	A Experimental Study in Type 2 Diabetes Patients	Data analysis completed	Intervention	2018-01-18	<NULL>	<NULL>	1576	Effect of Aerobic Train in the Type 2 Diabetes Patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-29	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8mwkyq	<NULL>	patients had to be voluntary; both gender; body mass index  igual or above 25 kg/m²; sedentary and diagnosed with T2DM	history of alcohol or drug abuse; diagnoses of cardiac pathologies; not being obese and sedentary; uncontrolled blood glucose spikes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-6m2fch	"A food compound with a preventive effect and / or treatment in lipid and glycemic disorders
In HIV-positive individuals on antiretroviral therapy"	Recruitment completed	Intervention	2017-08-29	<NULL>	<NULL>	1360	Bioactive Compound: nutritional therapy in the lipid and glycemic alterations caused by HIV infection in individuals using combined antiretroviral therapy	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Federal de Mato Grosso do Sul	Secretaria de Saúde Municipal de Campo Grande	https://ensaiosclinicos.gov.br/rg/RBR-6m2fch	<NULL>	Having aged 18 years or more; being on ART using or not lipid-lowering or hypoglycemic medications; perform laboratory tests according to request and control medical; participate from beginning to end of study and having signed the Term of Free and Informed.	Do not meet the inclusion protocol; Be a carrier of mental and renal diseases; Being pregnant; Be indigenous.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-2b4fyr	A long-term study with a multi-specialty approach to evaluate the acceptance of the accelerated recovery protocol in patients who were submited a  videolaparoscopic surgery for colorectal diseases	Recruitment completed	Intervention	2018-01-16	<NULL>	<NULL>	3050	A prospective study of the acceptance of the multimodal accelerated recovery protocol, Fast-Track,in patients submitted to videoolaparoscopic colorectal surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-15	Hospital Felicio Rocho	Hospital Felicio Rocho	https://ensaiosclinicos.gov.br/rg/RBR-2b4fyr	<NULL>	Patients older than 18 years of age, who had colorectal diseases and indicated elective surgical treatment by laparoscopy, with anastomosis, with or without ostomy	Patients submitted to conversion from laparoscopic surgery to open surgery, by laparotomy;Patients with colorectal cancer in the terminal stage;Patients with ASA III classification, or higher;Patients with mental disorders or psychiatric disorders;Patients with previous esophageal, gastroduodenal or pancreatic surgery;Patients with contraindication to laparoscopic surgery;Pregnant patients;Patients who refuse to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-5vkxts	A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment resistant Depression	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	770	An Open-label, Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2015-07-23	Centro De Psiquiatria E Pesquisas Sandra Ruschel Ltda	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-5vkxts	<NULL>	Research participants with direct Entry: The study population will include men and women with 18 years of age who meet the Manual of diagnostic criteria Diagnostic and Statistical of Mental Disorders (5th edition, DSM-5) for recurrent MDD or MDD single episode ( a single episode, the episode duration should be 2 years) without psychotic features, based on clinical evaluation and confirmed by Mini International Neuropsychiatric Interview (MINI). In screening, the research participant must have a MADRS total score 22, which corresponds to at least moderate depression .Research participants with direct entry will be eligible for screening regardless of whether they are taking or not currently oral antidepressant medications. In screening, the research participants with direct entry must habe no response to two different oral antidepressant treatments administered in proper dosage and proper duration (including oral antidepressant currently taken, if applicable), as measured in MGH-ATRQ and documented by history medical and / or pharmacy records / prescription for the current episode .Research participants  with transfer entry. All survey participants with transfer entry (elderly research participants with 65 years of age) who completed the double-phase induction blind ESKETINTRD3005 study will be eligible for this study: nonresponders research participants will join the study at the beginning of the open induction phase; responders research participants will join the study from the beginning of the optimization/maintenance phase.	Potential research participants will be excluded from participation in the study if they have previously shown no response of depressive symptoms to escetamina or ketamine in the current major depressive episode or all of the oral antidepressant treatment available in their country in the open induction phase (ie, duloxetine, escitalopram, sertraline and venlafaxine XR) in the current major depressive episode (based on MGH-ATRQ). Research participants will also be excluded if they have a DSM-5 diagnostic current or previous a psychotic or MDD disorder with psychosis, bipolar and related disorders (confirmed by MINI), obsessive compulsive disorder comorbid, intellectual disability (DSM-5 diagnostic codes 317 , 318.0, 318.1, 318.2, 315.8 and 319), autistic spectrum disorder, borderline personality disorder, antisocial personality disorder, histrionic personality disorder or narcissistic personality disorder; if they presented ideation / homicidal or suicidal ideation intent with any intention to act within 6 months before the screening phase according to the clinical judgment of the investigator and / or based on Suicide Severity Rating Scale Columbia ( CSSRS); or have a history of disorder or substance use moderate or severe alcohol according to the DSM-5. Furthermore, study participants with 65 ages will be excluded if they have neurodegenerative disorders (eg., Alzheimer&apos;s disease, vascular dementia, Parkinson&apos;s disease) or mild cognitive impairment evidence (MCI) or a score of the Mini Mental State Examination ( MMSE) 25.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-4hnphgb	A Mindfulness-Based Intervention to strengthen mental health and psychological resources in university students: a randomized controlled trial	Not yet recruiting	Intervention	2023-05-19	<NULL>	<NULL>	6094	Effects of a Mindfulness-Based Intervention on the mental health of Brazilian university students: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Universidade Cesumar	Universidade Cesumar	https://ensaiosclinicos.gov.br/rg/RBR-4hnphgb	<NULL>	Undergraduate students from Cesumar University; aged ≥18 years;  who wish to participate in the study; who can participate in at least six of the eight sessions of the mindfulness program; and who provide informed consent	Students with severe symptoms of anxiety (GAD-7 equal to or greater than 15), depression (PHQ-9 equal to or greater than 15) and severe mental disorder (self-reported); those who report experience with mindfulness, other meditations or mind-body practices such as yoga in the previous 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-6fk93n	A mode of mechanical ventilation applied without artificial airway in the post operative obesity surgery.	Recruitment completed	Intervention	2017-01-18	<NULL>	<NULL>	1162	Non-invasive ventilation with two pressure levels in the postoperative period of bariatric surgery by Roux-en-Y: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-03	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-6fk93n	<NULL>	"Patients with obesity class III and IV according to Brazilian Consensus of bariatric surgery, aged 18-40 years who underwent surgery during the period of the study and agree to participate. 
Patients with comorbidities of type OSA, hypertension, DM 2 and musculoskeletal problems; 
Informed consent approved and signed by the participants."	"Hemodynamic instability (represented by fever, decrease or increase of 20 mmHg of the reference value of blood pressure or heart rate 20 bpm and in severe hypoxemia); 
Patients with claustrophobia as the use of device therapy; 
Patients with difficulty in understanding to perform the maneuvers for breath tests; 
Patients with severe chronic lung disease prior;
Presence of contraindications to NIV: decreased level of consciousness, drowsiness, restlessness, or patient refusal, abdominal distension, nausea and vomiting."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-52y78f	A model of group therapy with children, in the Unified Health System, which works with the mind and body	Recruitment completed	Intervention	2020-11-19	<NULL>	<NULL>	4379	Benefits of mind and body dialogue for children&apos;s mental health, through a group play therapy model with children in public health	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2014-06-10	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-52y78f	<NULL>	Be aged between 8 and 10 years; both genders; be referred only to psychological care; have scores in the clinical range; T score greater than or equal to 60 on the internalization and / or externalization behavior scales and or total Child Behavior Checklist problems 6 to 18 years	Having a T-score on the total scale of the Child   Behavior Checklist 6 to 18 years old greater than 91 which would make group work difficult; mothers or guardians receiving psychotherapy or other mental health intervention; the child receiving intervention in any other area as a pedagogy; speech therapy; occupational therapy; psychiatry	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-774vv2	"A multicenter, randomized, double-blind study,
to verify whether the treatment with dextrocetamina association with clonidine in the form of cream for application to the skin is superior to placebo (cream without any drug) in the treatment of neuropathic pain."	Not yet recruiting	Intervention	2016-03-31	<NULL>	<NULL>	775	A multicenter randomized, double blind, placebo controlled study to determine the efficacy and safety of dextro-ketamine 1% in combination with clonidine 0.03% topical gel cream in the treatment of neuropathic pain syndromes.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-01-16	Faculdade de Medicina do ABC	Cristalia Produtos Químicos Farmacêuticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-774vv2	<NULL>	Signed and dated informed consent form. Male or female patients of any ethnic origin aged 18 years or over. Outpatient status. Patients with diagnosis of neuropathic pain associated with diabetic peripheral neuropathy (DPN), post herpetic neuralgia (PHN), post traumatic or post operative peripheral neuropathy and leprosy; DPN defined as peripheral, somatic or autonomic nerve damage attributable solely to diabetes mellitus; PHN defined as pain lasting longer than three months beyond the crusting of the skin lesions after an acute attack of Herpes zoster.Patients with moderate to severe pain all or most of the time, that has persisted for three months or longer (for patients with post herpetic neuralgia pain present for more than three months after healing of Herpes zoster skin rash. Patients with DN4 score 4. Patients with pharmacological therapies for neuropathic pain [anticonvulsants, selective and non- selective serotonin reuptake inhibitors, antidepressants, gabapentoids, nonsteroidal anti-inflammatory drugs (NSAIDS), salicylates, or acetaminophen] should be dose stabilized for at least 14 days before randomization and be willing to maintain therapy constant, avoid changes, or initiate new therapies throughout the study. Patients with normal cognitive and communicative ability as judged by clinical assessment and ability to complete self-report questionnaires. Women of childbearing potential must have a negative urine pregnancy test before randomization and must be using and willing to continue using adequate contraception (hormonal, double barrier or intrauterine device, according to medical indication) or be sexually abstinent during the study, and must not be lactating. Post-menopausal women for less than two years are considered of childbearing potential.	"Patients with severe pain associated with conditions other than diabetic peripheral neuropathy, post herpetic neuralgia, leprosy and post traumatic or post operative peripheral neuropathy [e.g., significant vasculitis, collagen vascular disorder, familial neuropathy, alcoholism, pernicious anemia, hepatitis, malignancy, syphilis, chronic inflammatory demyelinating polyradiculopathy, human immunodeficiency virus (HIV), medication-induced neuropathy, vitamin B12 deficiency, and others]. Patients with other sustained pain with intensity at, or greater than neuropathic pain. Patients with major depression requiring treatment. Patients with known allergy to clonidine or ketamine. Patients with ongoing use of a monoamine oxidase inhibitor. Patients with current use of antiarrhythmic drugs of class one (sodium channel blockers). Patients with uncontrolled diabetes mellitus (fasting blood glucose ? 130 mg/dL) or uncontrolled hypertension (systolic blood pression ? 180mmHg or diastolic ? 110mmHg). Patients using implanted medical device (e.g., spinal cord stimulator, intrathecal pump, or peripheral nerve stimulator) for pain treatment. Patients clinically hypotensive with a resting diastolic blood pressure &lt;60 mm Hg or a systolic blood pressure &lt;90 mm Hg.
Patients with diagnosis of any significant or unstable medical or psychiatric condition that would interfere with their ability to participate in the study. Patients with history of substance abuse disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) within the previous year. Patients with symptomatic or severe coronary insufficiency, clinically significant, cardiac conduction disturbances, myocardial infarction (within last 12 months), moderate to severe cerebrovascular disease, or severe chronic obstructive pulmonary disease (COPD) requiring oxygen therapy. Patients with serum creatinine value &gt;2 times the upper limit of normal or values for alanine transaminase (ALT) or aspartate transaminase (AST) &gt;2.5 times the upper limit of normal at screening. Patients treated with ketamine or clonidine oral, transdermal patch, or topical gel over the last four weeks prior to the screening visit.
Patients that used any topically applied pain medication within a period of 7 days before the screening. Patients with evidence of clinically significant peripheral vascular disease as evidenced by history of intermittent claudication or evidence of vascular ulcers, including venous stasis ulcers. Patients receiving any medications that could affect neuropathic pain not at stable dose for at least 14 days prior to the screening visit (other than medications containing NSAIDs and aspirin which must be stable for seven days prior to the screening visit). Patients receiving complementary therapies (acupuncture, TENS, central blockage)and/or &quot;alternative medicines&quot; (naturopathy, homeopathy, etc.) for pain treatment of 7 days prior to the screening visit. Patients with history of malignancy within the previous five years. Patients that have been hospitalized within 30 days of the screening visit, or planning to have a surgery during the study period. Patients with any dermatologic condition that could affect study drug absorption. Patients carrying pacemaker, impantable cardiac defibrillator, or cardiac resynchronizer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-4bxpkbb	A New Lung Treatment Device for Adult Patients with a Breathing Tube: a Randomized Controlled Clinical Trial	Not yet recruiting	Intervention	2024-06-27	<NULL>	<NULL>	7109	A new Lung Expansion Device for adult Tracheostomized patients: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Fundação Universidade Federal Do Amapá	Fundação Universidade Federal Do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4bxpkbb	<NULL>	Adult patients aged 18 and over. Hospitalized patients. Patients without impairment of cognition and understanding	Patients requiring invasive mechanical ventilation. Tracheostomy patients due to neuromuscular diseases or spinal cord injury. Patients who withdraw from participating in the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-4kgb26	A new method of exercise prescription creation for  cardiac rehabilitation to heart disease	Recruitment completed	Intervention	2016-05-16	<NULL>	<NULL>	847	A new method of exercise prescription creation for  cardiac rehabilitation program phase II to heart failure patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Hospital cardiológico costantini	Pontificia Universidade Catolica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4kgb26	<NULL>	"Patients with heart failure aged more than 50 years; Patients Functional class III or II and according to the New York Heart Association (NYHA ) ;
40 volunteers"	"- Patients under the age of 50 years;
patients With left ventricular ejection fraction&gt; or = 50 %;patients  with associated lung disease ;patients with orthopedic contraindication to practice exercises"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-7t7gnjk	A new proposal for Agility Training and Cognitive Training, simultaneously, in community-dwelling older adult	Terminated	Intervention	2023-05-18	<NULL>	<NULL>	6093	Agility Ladder: A new Dual-Task proposal for community-dwelling older adult	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-04	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7t7gnjk	<NULL>	"Age equal or superior to 60 years; have a score equal to or higher than 20 points in the mini 
mental state examination (MMSE); walk independently; make available for the participation of a four-month exercise program."	"Physical and / or cognitive impairment to prevent physical exercise; history of heart disease 
e.x. acute myocardial infarction), neurological (e.g. Alzheimer&apos;s disease), psychiatric (e.x. schizophrenia),cerebrovascular (e.i. cerebrovascular accident) or metabolic (e.i., diabetes mellitus I); not comply with a minimum of 90% of the total frequency of activities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-79fbccw	A new technique for treating gummy smile with the use of polyester thread	Recruitment completed	Intervention	2022-06-10	<NULL>	<NULL>	5425	Clinical evaluation of the lip repositioning technique using polyester thread for gummy smile treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	São Leopoldo Mandic	Instituto Militar de Engenharia	https://ensaiosclinicos.gov.br/rg/RBR-79fbccw	<NULL>	Healthy patients dissatisfied with a gummy smile; a minimal gingival exposition of 4mm	Patients with periodontal disease; pregnant and lactating women; smoking; systemic health problems; use of chronic medication that interferes in the gingival healing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-10kpgx78	A package of social media material targeting low back pain beliefs in the general community: a randomized controlled trial.	Not yet recruiting	Intervention	2022-09-28	<NULL>	<NULL>	5640	Effect of a digital pain education material on beliefs and attitudes about low back pain in the general community: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10kpgx78	<NULL>	Adults residing in Brazil; aged 18 years old or over; able to speak Portuguese; know how to read and understand reading in the Portuguese language; have access to the internet.	Not applicable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-8r9hy8f	A Phase 2 clinical trial of Inhaled Unfractionated Heparin (UFH) for the tretatment of Hospitalised Patients with COVID-19	Not yet recruiting	Intervention	2021-01-06	<NULL>	<NULL>	4465	A Phase 2 clinical trial of Inhaled Unfractionated Heparin (UFH) for the tretatment of Hospitalised Patients with COVID-19	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2021-01-15	Galeno Desenvolvimento de Pesquisas Clínicas Ltda	Galeno Desenvolvimento de Pesquisas Clínicas Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8r9hy8f	<NULL>	Patients hospitalized with COVID-19 who do not require immediate mechanical ventilation (points 3-5 on the ordinal scale). Age from 18 to 80 years. Able to understand the nature and purpose of the study, including risks and adverse effects and with the intention of cooperating with the researcher and acting in accordance with the requirements of the entire trial, which is confirmed by signing the Term Informed Consent Form, prior to any study procedure. Women of childbearing potential should use a safe and effective method of contraception throughout the study. If the participant chooses to abstain from sex or practice any type of relationship that does not pose a risk of pregnancy, the use of contraception is not mandatory.	The participant is known to be hypersensitive to the studied drug (heparin) or to chemically related compounds. History of serious adverse reactions or hypersensitivity to any drug. The participant has any condition that prevents him from participating in the study due to the investigator&apos;s judgment. A participant shows a positive result for beta-HCG test and/or urine test for pregnancy; delivery or abortion in the 12 weeks prior to the scheduled vaccine administration date. Present COPD.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-2kjm6y	A phase 2 randomized double-blind placebo-controlled study to evaluate safety of BLD-2660 and its activity against COVID-19 virus in hospitalized subjects recently diagnosed with COVID-19 in comparison to standard of care treatment	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4166	A phase 2 randomized double-blind placebo-controlled study to evaluate safety and antiviral activity of BLD-2660 in hospitalized subjects with recently diagnosed COVID-19 compared to standard of care treatment	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-05-22	Blade Therapeutics Inc	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-2kjm6y	<NULL>	At least 18 years of age at the time of signing the ICF. Hospitalized for COVID-19. Diagnosed with COVID-19 as defined by having at least 2 of the following signs or symptoms within the past 2 days: a.fever defined as a body temperature higher than 38.0°C oral, or higher than 38.3°C rectal, higher than 37.7°C forehead or higher than 38.7°C aural (axillary temperatures are not allowable); b.cough; c.fatigue; d.shortness of breath. Radiographic evidence (chest x-ray or CT scan) of one the following: a. ground-glass opacities, or b.local or bilateral patchy infiltrates, or c.interstitial pulmonary infiltrates. Oxygen requirements: a. spO2 higher than 94% on ambient air or b.requires supplemental oxygen administration by nasal cannula, simple face mask, or other similar oxygen delivery device. Male and/or female subjects. Contraception use by men or women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. All subjects (male or female) who are of childbearing potential must agree to use highly effective contraception during the study. Female subjects and male partners of female subjects must continue to use highly effective contraception for 30 days after the last dose of study drug. Female subjects should not donate oocytes during this time. Male subjects and female partners of male subjects must continue to use highly effective contraception for 90 days. Male subjects must agree not to donate sperm during this time. Women of childbearing potential must have a negative serum pregnancy test at screening within 72 hours prior to first administration of study drug. Women not of childbearing potential must be postmenopausal (defined as cessation of regular menstrual periods for at least 1 year. Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the ICF and in this protocol	"Active bacterial pneumonia infection. Known active tuberculosis (TB). History of Child-Pugh B or C cirrhosis. History of ischemic heart disease or myocardial infarction or acute coronary syndrome. Subjects requiring supplemental oxygen higher than 0.75 FiO2. It is not in the best interest of the subjects to participate, in the opinion of the treating
Investigator. Female subjects who are pregnant or breastfeeding or expecting to conceive within the projected duration of the study, starting with the screening visit through 90 days after the last dose of study drug. The following laboratory parameters are excluded:
alanine aminotransferase (ALT) or aspartate aminotransferase (AST) higher than 5 x upper limit of normal (ULN); creatinine clearance lower than 50 mL/min. Requiring, or expected to require mechanical ventilation at screening. Treatment with chloroquine or hydroxychloroquine at study entry. Treatment with anti-IL-6, anti-IL-6 receptor antagonists, or with Janus kinase inhibitors (JAKi) in the past 30 days or plans to receive during the study period. Participation in any other clinical study of an experimental drug treatment for COVID-19 within 6 half-lives of the experimental treatment. Current participation or have participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study drug. Unable to swallow solid oral medication or known malabsorption disorder. Subjects who have allergy to BLD-2660 or inactive components of BLD-2660"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-758cbn	A Phase I/II open-label study at a single research center to evaluate the safety, tolerability, and effects of RGX-111 gene therapy given directly into the central nervous system in subjects with severe mucopolysaccharidosis type I	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1925	A phase I/II single center, open-label study to evaluate the safety, tolerability,  pharmacodynamics and preliminary efficacy of intracisternal RGX-111 gene therapy in subjects with severe mucopolysaccharidosis type I	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2018-11-01	Hospitais de Clínicas de Porto Alegre	REGENXBIO Inc.	https://ensaiosclinicos.gov.br/rg/RBR-758cbn	<NULL>	A male or female less than 3  years of age; The subject’s legal guardian(s) is(are) willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures; Has a documented diagnosis of severe Mucopolysaccharidosis Type I (MPS I) -Hurler confirmed by homozygosity or compound heterozygosity for mutations exclusively associated with the severe phenotype; Has an intelligent quotient (IQ) score of  greater than or equal to  55; Has sufficient auditory and visual capacity, with or without aids, to complete the required protocol testing and willing to be compliant with wearing the aid, if applicable, on testing days	"Has a contraindication for an intracisternal injection (IC); Has any neurocognitive deficit not attributable to Mucopolysaccharidosis Type I (MPS I) or has a diagnosis of a neuropsychiatric condition that may, in the opinion of the PI, confound interpretation of study results; Has any contraindication to lumbar puncture; Has undergone hematopoetic stem cell transplantation (HSCT); Has had prior treatment with an Adeno-associated virus (AAV)-based gene therapy product; Has received intrathecal (IT) laronidase at any time and experienced a significant Adverse event (AE) considered related to IT administration that, in the opinion of the PI, would put the subject at undue risk; Has a platelet count less than 100,000 per
microliter; Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 3 × upper limit of normal (ULN) or total bilirubin greater than 1.5 × ULN at screening, unless the subject has a previously known history of Gilbert’s syndrome; Has a history of human immunodeficiency virus (HIV) or hepatitis B or hepatitis C virus infection, or positive screening tests for hepatitis B surface antigen or hepatitis B core antibody, or hepatitis C or HIV antibodies"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-5hzmjx	"A Phase II Study of Dasatinib Therapy in Children and Adolescents with Ph+ Leukemia
with Resistance or Intolerance to Imatinib"	recruiting	Intervention	2011-06-27	<NULL>	<NULL>	6	"A Phase II Study of Dasatinib Therapy in Children and Adolescents with Ph+ Leukemia
with Resistance or Intolerance to Imatinib"	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2010-03-01	Bristol-Myers Squibb	Bristol-Myers Squibb	https://ensaiosclinicos.gov.br/rg/RBR-5hzmjx	<NULL>	"Written informed consent from subject, or from parents or legal guardians for
minor subjects, according to local law and regulation.
    Cohort #1: Subjects must have Ph+ CML in CP which is defined by the
presence of all the following criteria:
  &lt; 15% blasts in peripheral blood and bone marrow
  &lt; 20% basophils in peripheral blood
  &lt; 30% blasts + promyelocytes in peripheral blood and bone marrow
  &gt;= 100 X 109 platelets/L unless thrombocytopenia secondary to recent
treatment
  No extramedullary involvement other than liver or spleen
  Ph+ or variant must be demonstrated by bone marrow cytogenetics
   Cohort #2: Subjects must have Ph+ ALL or Ph+ AP- or BP-CML:
 Ph+ ALL have to be in first or subsequent relapse [ &gt;= 25% blasts in bone
marrow] or fail to achieve remission after imatinib
 AP-CML must meet at least one of the following criteria:
 &gt;= 15% but &lt; 30% blasts in peripheral blood or bone marrow
 &gt;= 30% blasts + promyelocytes in peripheral blood and in bone marrow
(but percent alone has to be &lt; 30%)
 &gt;= 20% basophils in peripheral blood or bone marrow
 &lt; 10 X 109/L platelets unrelated to therapy
  BP-CML has to meet all the following criteria:
 &gt;= 30% blasts in peripheral blood or bone marrow
 Presence of extramedullary blastic disease other than lymph nodes,
liver or spleen
 Subjects have to be proven resistant or intolerant to imatinib:
 For both cohorts, intolerance to imatinib is defined as the occurrence of any
toxicity grade &gt;= 3 considered at least possibly related to imatinib and that led
to discontinuation of previous imatinib therapy.
 For Cohort #1, resistance to imatinib must meet at least one of the following
criteria:
 Failure to achieve, or loss of, CHR after &gt;= 3 months of imatinib at a
daily dose of 260 mg/m2 or greater;
 Failure to achieve MCyR after &gt;=6 months or CCyR after &gt;= 12 months of imatinib therapy at a daily dose of 260 mg/m2 or greater;
 Absolute increase of &gt;= 30% of the percentage of Ph+ metaphases,
confirmed at &gt;= 6 week interval, after prior MCyR to imatinib at a daily
dose of 260 mg/m2 or greater.
 For Cohort #2, resistance to imatinib must meet at least one of the following
criteria:
 Failure to achieve CHR while on imatinib after a &gt;= 4-week treatment
or a &gt;= 50% increase in peripheral blood blasts over a 2-week period
 Subjects who achieved a CHR subsequently no longer meet the criteria
consistently over a consecutive 2-week period while receiving imatinib
 Absolute increase of &gt;= 30% of the percentage of Ph+ metaphases,
confirmed at &gt;= 6 week interval, after prior MCyR to imatinib.
 Lansky or Karnofsky scale &gt; 50 
 Life expectancy &gt;= 12 weeks
 Subjects must have recovered to baseline or Grade 1 (NCI CTCAE, version 3.0)
from the toxicities (except alopecia) resulting from recent therapies, including
chemotherapy, hormonal therapy, immunotherapy, biological therapy or
investigational product and radiation therapy.
 Serum Na, K, NaHC03, Mg, P and Ca levels within institutional normal limits
and AST, ALT, bilirubin, BUN or urea, creatinine ? Grade 2 (NCI CTCAE,
Version 3.0).
 Men and women, age &gt;= 1 to &lt; 21 years.
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 4 weeks after
the last dose of investigational product in such a manner that the risk of pregnancy
is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation,
or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined
as:
• Amenorrhea &gt;= 12 consecutive months without another cause or
• For women with irregular menstrual periods and on hormone replacement
therapy [HRT], a documented serum follicle stimulating hormone [FSH] level
&gt; 35 mIU/mL)
Women who are using oral contraceptives, other hormonal contraceptives
(vaginal products, skin patches, or implanted or injectable products), or
mechanical products such as an intrauterine device or barrier methods
(diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing
abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 12 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Sexually active fertile men not using effective birth control if their partners are WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 4 weeks after the last dose of
investigational product.
Subjects for whom potentially-curative therapy is available, including
hematopoietic stem-cell transplantation (HSCT) at the time when subject is
assessed for enrollment
Subjects with isolated central nervous system disease are excluded from study.
This criterion relates to subjects with CNS-3 disease (? 5 leukemic blasts per
cubic millimeter in a sample with &lt; 10 erythrocytes per cubic millimeter).
Subjects with CNS-1 (no detectable blast cells in a sample of cerebrospinal fluid)
and CNS-2 (&lt; 5 leukemic blast cells in a sample with &lt; 10 erythrocytes per cubic
millimeter) are eligible for study. Subjects with a combined relapse which also
involves the CNS are eligible, provided this is asymptomatic (no convulsions or
other neurological symptoms).
Isolated extramedullary disease, with &lt; 5% blasts in bone marrow
Any serious uncontrolled medical disorder that would impair the ability of the subject to receive protocol therapy, including:
 Ongoing uncontrolled infection
 Clinically-significant disorder of platelet function (e.g. von Willebrand’s
disease) or ongoing gastrointestinal bleeding
 Clinically-significant cardiovascular disease, congenital long QT syndrome,
history of ventricular arrhythmias or heart block, or prolonged QTc interval &gt;
450 ms (Fridericia correction) on baseline electrocardiogram
 Subjects diagnosed with the T315I mutation (mutation testing should be
performed according to the investigator’s standard practice and is not
mandatory at sites without BCR-ABL testing available).
 Subjects who have experienced hypersensitivity to dasatinib or to any of the excipients. Inactive ingredients in dasatinib tablets include: lactose
monohydrate, microcrystalline cellulose, croscarmellose sodium,hydroxypropyl cellulose, and magnesium stearate. The tablet coating consists of hypromellose, titanium dioxide, and polyethylene glycol.
 Subjects with hereditary problems of galactose intolerance or Lapp lactase
deficiency or glucose-galactose malabsorption.
 Expected non-compliance to protocol schedule or unable to have regular followup
due to psychological, social, familial or geographic reasons
Prior therapy with dasatinib.
Any investigational agent or any other anti-cancer agent within 14 days prior to
treatment start. Imatinib mesylate may be continued up to 7 days before treatment
start, or, in the presence of rising peripheral blast cells, imatinib may be continued up to 2 days before treatment start. If required for control of peripheral blast cells,hydroxyurea, corticosteroids, 6-mercaptopurine or 6-thioguanine may be given up
to 2 days before treatment start.
Subjects requiring ongoing medications which may:
 Have a known risk of causing QTc prolongation ii) Irreversibly inhibit platelet function, or anticoagulants (Does not apply to low-dose heparin for prophylaxis or to heparin flushes for i.v. lines)
For Cohort #3: Prior chemotherapy, immunotherapy, or radiotherapy for CML
with the exception of hydroxyurea.
Prisoners or subjects who are involuntarily incarcerated
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-3j2xxq	A phase III double blind placebo controlled  study of MEDI4736 for improving survival in patients facing completely ressected Non-Small Cell Lung Cancer	Recruiting	Intervention	2019-08-29	<NULL>	<NULL>	2917	A phase III prospective double blind placebo controlled randomized study of adjuvant MEDI4736 in completely ressected Non-Small Cell Lung Cancer	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-03-02	Canadian Cancer Trials Group	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-3j2xxq	<NULL>	Histologically confirmed diagnosis of primary non-small cell carcinoma of the lung (NSCLC) according to WHO Classification of Tumours. Patients with large-cell neuroendocrine carcinomas are not eligible. Patients must consent to release of an adequate histological specimen for this protocol, and the tissue blocks must be available for submission after registration. Failure to provide tissue blocks for PD-L1 expression assessment will render the patient ineligible; patients must be classified post-operatively as Stage IB (&gt; 4cm in the longest diameter), II or IIIA based on pathologic criteria; surgery and previous therapy for NSCLC: a pre-surgical PET scan of the thorax and a MRI or CT scan of the brain is considered standard of care and thus must be done prior to surgery. Patients in whom this was not done prior to surgery may still be enrolled providing that appropriate imaging is performed prior to randomization; b. complete surgical resection of the primary NSCLC is also mandatory. All gross disease must have been removed at the end of surgery. All surgical margins of resection must be negative for tumour; c. lymph node mapping is defined by The International Association for the Study of Lung Cancer (IASLC) lymph node map. The nodal tissue should be labelled according to the recommendations of the American Thoracic Society. Accordingly, it is recommended that a minimum of 3 (three) lobe specific mediastinal nodal stations (N2), one of which should include station 7, and at least one N1 station - inclusive of the ones removed with the pulmonary specimen have been sampled at the end of the procedure; d. if preoperative CT and/or PET are suspicious for mediastinal nodal involvement, it is recommended that invasive mediastinal staging with mediastinoscopy or EBUS-TBNA be performed. Station 5 or 6 lymph nodes may be accessed by anterior mediastinotomy or VATS. This may also occur at the time of the surgical resection. If invasive staging shows disease in regional lymph nodes, they must be surgically removed. It is recommended that complete mediastinal lymph node dissection be undertaken for stage IIIA tumours; e. surgery may consist of lobectomy, sleeve resection, bilobectomy or pneumonectomy as determined by the attending surgeon based on the intraoperative findings. Patients who have had only segmentectomies or wedge resections are not eligible for this study. Note: Where a resection has been extended by means of a wedge resection of an adjacent lobe in order to ensure complete resection of a tumour at or crossing a fissure between lobes, if the margins are clear this is acceptable. Where the resection of a second tumour nodule, even where not considered to be a co-primary, is undertaken by means of a wedge resection of a separate lobe then the patient is not eligible; prior systemic therapy: a. pre-operative (neo-adjuvant) platinum based or other chemotherapy is not permissible; b. patients may have received prior post-operative platinum based chemotherapy as per standard of care. Patients who discontinue chemotherapy for toxicity prior to completion of all planned chemotherapy are eligible; c. if adjuvant platinum-based chemotherapy is given, it is strongly recommended that this be started within 8 weeks of surgery; d. patients must have recovered from all acute, reversible toxic effects from chemotherapy (excluding alopecia); e. patients who have not received adjuvant chemotherapy, and meet all other eligibility criteria, may be eligible under the following circumstances: all patients who are eligible for adjuvant chemotherapy must be offered adjuvant chemotherapy prior to any discussion about this trial and that must be documented; the patient has declined adjuvant chemotherapy, and in the opinion of the investigator, this is the patient’s final decision after receiving appropriate information and adequate time to make the decision; if in the view of the investigator, adjuvant chemotherapy is contraindicated due to an underlying intercurrent illness/ laboratory abnormality, which is not considered reversible within a reasonable timeframe for the patient to be eligible for adjuvant therapy, which must be documented; no prior anticancer therapy for treatment of NSCLC other than standard post-operative adjuvant chemotherapy is permissible; radiation: patients with N2 disease only who receive adjuvant post-operative radiation therapy are eligible provided they meet the protocol specified timing criteria for surgery, adjuvant chemotherapy and randomization. Pre-operative radiation therapy is not permissible; timing between surgery and adjuvant chemotherapy and randomization: surgery: a. a minimum of 3 weeks must have elapsed between NSCLC surgery and randomization. A minimum of 4 weeks must have elapsed for other types of surgery. Complete post-operative wound healing must have occurred following any surgery; b. no more than 10 weeks may have elapsed between surgery and randomization for patients who have not received adjuvant chemotherapy; for patients after adjuvant chemotherapy: for patients who received post-operative adjuvant platinum-based chemotherapy, a minimum of 2 weeks must have elapsed (but no more than 10 weeks) from the last administered dose of chemotherapy to the date of randomization; for patients after post-operative adjuvant radiation therapy: for patients who received post-operative adjuvant radiation therapy, the patient must meet the protocol specified timing criteria for surgery, adjuvant chemotherapy and randomization. The post-operative radiation therapy must be completed prior to randomization; the patient must have an ECOG performance status of 0, 1; hematology (done within 14 days prior to randomization and with values within the ranges specified in the protocol): if anemic, patients should be asymptomatic and should not be decompensated. Transfusions are permissible; biochemistry (done within 14 days prior to randomization and with values within the ranges specified in the protocol); patient able and willing to complete the quality of life, economics and other questionnaires. The baseline assessment must already have been completed within required timelines prior to randomization. Inability (illiteracy, loss of sight, or other equivalent reason) to complete the questionnaires will not make the patient ineligible for the study; patients must be accessible for treatment and follow-up; age of at least 18 years	Patients with a history of other malignancies, except adequately treated non-melanoma skin cancer, curatively treated in-situ cancer, or other malignancies curatively treated with no evidence of disease for &gt; 5 years following the end of treatment and which, in the opinion of the treating physician, do not have a substantial risk of recurrence of the prior malignancy; a combination of small cell and non-small cell lung cancer, pulmonary carcinoid tumour or large-cell neuroendocrine carcinoma (LCNEC); history of autoimmune disease, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener’s granulomatosis, Sjögren’s syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis. Note: patients with Grave’s disease and/or psoriasis not requiring systemic therapy within the last two years from randomization and patients with hypothyroidism (e.g. following Hashimoto syndrome) stable on hormone replacement are not excluded; history of primary immunodeficiency, history of allogenic organ transplant, use of immunosuppressive agents within 28 days of randomization* or a prior history of severe (grade 3 or 4) immune mediated toxicity from other immune therapy (* note: intranasal/inhaled corticosteroids or systemic steroids that do not to exceed 10 mg/day of prednisone or equivalent dose of an alternative corticosteroid are permissible); live attenuated vaccination administered within 30 days prior to randomization; history of hypersensitivity to MEDI4736 or any excipient; patients who have experienced untreated and/or uncontrolled cardiovascular conditions and/or have symptomatic cardiac dysfunction (unstable angina, congestive heart failure, myocardial infarction within the previous year or cardiac ventricular arrhythmias requiring medication, history of 2nd or 3rd degree atrioventricular conduction defects). Patients with a significant cardiac history, even if controlled, must have a LVEF &gt; 50% within 12 weeks prior to randomization; concurrent treatment with other investigational drugs or anti-cancer therapy; patients with active or uncontrolled infections or with serious illnesses or medical conditions which would not permit the patient to be managed according to the protocol [this includes but is not limited to: known clinical diagnosis of tuberculosis; known active hepatitis B infection (positive HBV surface antigen (HBsAg)). Patients with a past or resolved hepatitis B infection (defined as presence of hepatitis B core antibody (anti-HBc) and absence of HBSAg) are eligible; known active hepatitis C infection. Patients positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RA; known human immunodeficiency virus infection (positive HIV antibodies); known pneumonitis or pulmonary fibrosis with clinically significant impairment of pulmonary function]; pregnant or lactating women. Women of childbearing potential must have a urine pregnancy test proven negative within 14 days prior to randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-84s2yw	A phase III double-blinded, placebo controlled study of Pracinostat in association with Azacitidin for improving survival in patients facing Acute Myeloid Leukemia	Recruiting	Intervention	2019-04-22	<NULL>	<NULL>	2617	A phase III, double-blind, placebo-controlled, multicenter, randomized study of Pracinostat in combination with Azacitidine in patients older or equal to 18 years with newly diagnosed Acute Myeloid Leukemia unfit for standard induction chemotherapy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-10-22	Helsinn Healthcare SA	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-84s2yw	<NULL>	Male or female patients equal or older than 18 years of age with newly diagnosed, histologically confirmed, AML including de novo, secondary to antecedent hematologic disorders, or treatment-related disease with intermediate or unfavorable-risk cytogenetics; patients unable to receive intensive chemotherapy regimens at enrollment, based on one of the following: a. age equal older than 75 years, or b. age less than 75 years with at least 1 of the following co-morbidities: b1. an ECOG performance status of 2, b2. clinically significant cardiovascular disease defined as: left ventricular ejection fraction (LVEF) equal or less than 50% measured within 3 months prior to Day 1, confirmed by ECHO/MUGA, congestive heart failure requiring medical therapy, chronic stable angina requiring medical therapy, prior cerebrovascular accident with sequelea, b3. clinically significant pulmonary disease defined as: forced expiratory volume in 1 second (FEV1) equal or less than 65% of expected, lung diffusing capacity for carbon monoxide (DLCO) equal or less than 65% of expected confirmed by pulmonary tests, b4. diabetes mellitus with symptomatic end-organ damage (e.g., retinopathy, nephropathy, neuropathy, vasculopathy), b5. autoimmune inflammatory conditions (e.g., rheumatoid arthritis, systemic lupus erythematous, inflammatory bowel disease, or similar) requiring chronic disease modifying therapy (e.g., etanercept, adalimumab, infliximab, rituximab, methotrexate, or similar), b6. class III obesity defined as a Body Mass Index (BMI) more than 40 kg/m2, b7. renal impairment defined as serum creatinine greater than 1.3 mg/dL (greater than 115 ?mol/L) or creatinine clearance less than 70 mL/min, b8. clinically significant cognitive impairment defined as requiring medical therapy and/or assistance with activities of daily living; presence of at least 20% blasts in bone marrow; peripheral white blood cell (WBC) count less than 30,000/?L, for cyto-reduction, hydroxyurea is allowed during screening and up to Cycle 1, Days 1-14, to reduce WBC count to less than 30,000 ?L prior to Day 1. After Cycle 1, Day 14, hydroxyurea is prohibited; ECOG performance status less or equal to 2; adequate organ function as evidenced by the following laboratory findings: total bilirubin less than 2 × upper limit of normal (ULN) or less than 3 × ULN for patients with Gilbert-Meulengracht Syndrome, Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less or equal to 2.5 × ULN; serum creatinine less or equal to 1.5 × ULN or creatinine clearance equal or greater than 50 mL/min according to institutional standards; QT-interval corrected according to Fridericia’s formula (QTcF) equal or less than 450 ms on electrocardiogram (ECG) at screening; male patient who is surgically sterile, or male patient who is willing to agree to remain completely abstinent (refrain from heterosexual intercourse) or who use barrier contraceptive measures and agree to refrain from donating sperm during the entire study treatment period; female patient who is of childbearing potential willing to use adequate contraceptive measures while participating on study, or willing to completely abstain from heterosexual intercourse during the entire study treatment period; female patient who is of childbearing potential must have a negative serum pregnancy test result within 3 weeks prior to starting study drugs; willing to provide voluntary written informed consent before performance of any study related procedure not part of normal medical care; willing and able to understand the nature of this study and to comply with the study and follow-up procedures.	Able to receive intensive induction chemotherapy; AML-associated inv(16)/t(16;16)/del(16q), t(15;17) (i.e. promyelocytic leukemia) with/without secondary aberrations; t(8;21) lacking del (9q) or complex karyotypes; resence of an active malignant disease within the last 12 months, with the exception of adequately treated cervical cancer in-situ, non-melanoma skin cancer and superficial bladder tumors (Ta [non-invasive tumor], Tis [carcinoma in situ] and T1 [tumor invades lamina propria]). Other malignancies may be considered after consultation with the Medical Monitor; life-threatening illnesses other than AML, uncontrolled medical conditions or organ system dysfunction that, in the Investigator’s opinion, could compromise the patient’s safety or put the study outcomes at risk; uncontrolled arrhythmias; any Class 3-4 cardiac diseases as defined by the New York Heart Association (NYHA) functional classification; evidence of central nervous system (CNS) involvement; previous chemotherapy for AML except for the following, which are allowed: hydroxyurea for cytoreduction, one course of hypomethylating agent therapy (i.e.; up to 7 doses of azacitidine or 3-5 days of decitabine) within 30 days prior to enrollment (Day1); use of experimental drugs within 30 days prior to screening; received prior HDAC inhibitor therapy; received prior treatment with a hypomethylating agent, except as allowed in Exclusion Criterion 7.b; known hypersensitivity to any components of pracinostat, AZA, or mannitol; history of human immunodeficiency virus (HIV) or an active and uncontrolled infection with hepatitis C virus (HCV) or hepatitis B virus (HBV); gastrointestinal (GI) tract disease that causes an inability to take oral medication, malabsorption syndrome, or a requirement for IV alimentation; prior surgical procedures affecting absorption; or uncontrolled inflammatory GI disease (e.g., Crohn’s disease, ulcerative colitis); any disease(s), psychiatric condition, metabolic dysfunction, or findings from a physical examination or clinical laboratory test result that would cause reasonable suspicion of a disease or condition, that contraindicates the use of pracinostat and/or AZA, that may increase the risk associated with study participation, that may affect the interpretation of the results, or that would make the patient inappropriate for this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-7spw98	A Phase III Open Label, Randomized, 2 Arm Study of Ixabepilone Administered Every 21 Days Versus Paclitaxel Or Doxorubicin Administered Every 21 Days in Women with Advanced Endometrial Cancer Who Have Previously Been Treated with Chemotherapy	recruiting	Intervention	2011-06-21	<NULL>	<NULL>	4	A Phase III Open Label, Randomized, 2 Arm Study of Ixabepilone Administered Every 21 Days Versus Paclitaxel Or Doxorubicin Administered Every 21 Days in Women with Advanced Endometrial Cancer Who Have Previously Been Treated with Chemotherapy	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2010-03-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7spw98	<NULL>	"All subjects must be informed of the investigational nature of this study and must
sign and give written informed consent in accordance with institutional and
federal guidelines.
Histologic or cytologic diagnosis of endometrial carcinoma.
Evidence that the cancer is locally advanced, recurrent or metastatic and not
curable by local measures (ie, surgery, radiation).
Karnofsky performance status (KPS) 70, 80, 90, or 100 (see Appendix 2).
Subjects must have measurable or non-measurable disease (see Section 6.4.3) that
has progressed since last treatment. A maximum of 140 subjects with
non-measurable disease will be randomized.
Notes:
 If the subject’s only disease is confined to a solitary lesion, its neoplastic
nature must be confirmed by histology or cytology.
 Disease in a previously irradiated field is acceptable as the only site of
measurable disease only if there has been clear progression since completion
of radiotherapy.
 All therapy directed at endometrial cancer must be discontinued 21 days prior to start of treatment, except for hormonal therapy which must be discontinued at
least 1 week prior to start of study treatment. Note: concurrent administration of hormone replacement therapy is allowed.
Subjects must have received one and only one prior chemotherapy (ie, cytotoxic)
regimen for locally advanced, recurrent or metastatic endometrial cancer. Subjects
with 1 additional prior chemotherapy regimen in the neoadjuvant or adjuvant
setting are allowed. Adjuvant/neoadjuvant therapy is defined as post or
preoperative therapy for Stage 1, 2, or 3 disease.
 Subjects may have received any number of prior non-cytotoxic regimens such as
monoclonal antibodies, cytokines, signal transduction inhibitors, or hormonal
therapy.
 Previous radiation therapy is allowed.
Women, ages 18 to older.
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 4 weeks after the last dose of investigational product in such a manner that the risk of pregnancy is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined as:
  Amenorrhea ? 12 consecutive months without another cause or
  For women with irregular menstrual periods and on hormone replacement
therapy (HRT), a documented serum follicle stimulating hormone (FSH) level &gt; 35 mIU/mL
Women who are using oral contraceptives, other hormonal contraceptives
(vaginal products, skin patches, or implanted or injectable products), or
mechanical products such as an intrauterine device or barrier methods
(diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing
abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 4 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding.
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Carcinosarcoma (malignant mixed mullerian tumor)
Endometrial leiomyosarcoma and endometrial stromal sarcomas.
Subjects with no prior chemotherapy (ie, cytotoxic) for locally advanced,
recurrent or metastatic endometrial cancer or subjects that received 2 or more
prior chemotherapy (ie, cytotoxic) regimens for locally advanced, recurrent or
metastatic endometrial cancer.
Subjects with known brain metastases. Note: brain scans are not required.
Receipt of prior ixabepilone therapy.
Concurrent active infection requiring antibiotics or other therapy.
Concurrent unstable disease or other debilitating illness that could jeopardize
participation such as congestive heart failure, unstable angina, myocardial
infarction or other cardiac disease within last 6 months.
For subjects whose prior therapy did not include an anthracycline (eg,
doxorubicin) and therefore may be randomized to doxorubicin, LVEF of &lt; 50%
as measured by multi-gated radionuclide angiography (MUGA) or
echocardiography (ECHO).
History of prior malignancy within last 5 years except non-melanoma skin cancer,
carcinoma in situ of the cervix, or carcinoma in situ of the breast not treated with chemotherapy.
Known human immunodeficiency viral (HIV) infection.
Psychiatric disorders or other conditions rendering the subject incapable of
complying with the requirements of the protocol.
Absolute neutrophil count (ANC) &lt; 1500/mm3.
Platelets &lt; 100,000/ mm3.
Hemoglobin &lt; 9 g/dL.
Total bilirubin &gt; 1.5 times the institutional upper limit of normal (ULN), except for subjects with Gilbert’s disease.
AST or ALT &gt; 2.5 times the institutional upper limit of normal (ULN).
Serum creatinine &gt; 1.5 x institutional upper limit of normal (ULN).
Grade ? 2 neuropathy (sensory or motor).
Known allergy to any of the study drugs or their excipients such as, prior severe
HSR to agents containing Cremophor® EL.
No concurrent therapy directed at endometrial cancer (chemotherapy, hormonal,
or investigational during the study).
Subjects must not continue or institute treatment with the following strong
inhibitors of CYP3A4 from 72 hours prior to the initiation of study therapy until
end of treatment with ixabepilone or paclitaxel: Ketoconazole, itraconazole,
clarithromycin, atazanavir, nefazodone, saquinavir, telithromycin, ritonavir,
amprenavir, indinavir, nelfinavir, delavirdine, or voriconazole (See IB1).
Other concurrent anti-tumor, chemotherapy, hormonal therapy, immunotherapy
regimens or radiation therapy, standard or investigational therapy (see
Section 5.5).
Prisoners or subjects who are involuntarily incarcerated.
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-4bfx9c	A phase III study for the evaluation of the immunogenicity and reactogenicity of GSK Biologicals&apos; Quadrivalent Split Virion Influenza Vaccine Fluarix Tetra (2015 season Southern Hemisphere) in adults 18 years of age and above	Recruitment completed	Intervention	2016-01-06	<NULL>	<NULL>	673	201959 (FLU D-QIV-017) - A phase III study to assess immunogenicity and reactogenicity of GSK Biologicals&apos; Quadrivalent Split Virion Influenza Vaccine Fluarix Tetra (2015 season southern hemisphere) in adults 18 years of age and above	<NULL>	3, non-randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-04-29	GlaxoSmithKline Biologicals	GlaxoSmithKline Biologicals	https://ensaiosclinicos.gov.br/rg/RBR-4bfx9c	<NULL>	Male and female subjects aged 18 years or above at the time of vaccination; healthy with well-controlled chronic diseases;  will comply with the requirements of the protocol and give written informed consent. Female subjects of non-childbearing potential. Female subjects of childbearing potential may be enrolled in the study, if the subject has practiced adequate contraception for 30 days prior to vaccination, and has a negative pregnancy test at screening and on the day of vaccination, and has agreed to continue adequate contraception during the entire treatment period and for two months after completion of the vaccination series	Use of any investigational or non-registered product, drug or vaccine, other than the study vaccine during the period starting 30 days before the dose of study vaccine or planned use during the study period; any medical condition that in the judgment of the investigator would make intramuscular injection unsafe; chronic administration, defined as more than 14 consecutive days, of immunosuppressants or other immune-modifying drugs within six months before study start or planned administration during the study; planned administration of a vaccine not foreseen by the study protocol in the period starting 30 days before the study vaccination and during the entire study period; administration of immunoglobulins and/or any blood products within the three months preceding the first dose of study vaccine or planned administration during the study period; administration of an influenza vaccine within the 6 months preceding the study start or planned use of such vaccines during the study period; concurrently participating in another clinical study, at any time during the study period, in which the subject has been or will be exposed to an investigational or a non-investigational product; clinically or virologically confirmed influenza infection within the six months preceding the study vaccination; any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination; acute disease and/or fever at the time of enrollment; acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory testing performed at the screening visit; chronic underlying disease not stabilised or clinically serious;history of chronic alcohol consumption and/or drug abuse; history of Guillain-Barré syndrome; history of any reaction or hypersensitivity likely to be exacerbated by any component of the vaccine, including latex; history of severe adverse reaction to a previous influenza vaccination; anaphylaxis following the administration of vaccine(s);  pregnant or breastfeeding female; subject planning to become pregnant or planning to discontinue contraceptive precautions during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-7zbxq5	A physiotherapy protocol based on the preferences of the individual with Parkinson disease for the health empowerment	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1524	Efects of physiotherapy with aproach based on patient preferences and conventional physiotherapy in motor and non-motor symptoms of individuals with Parkinson disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade do Estado de Santa Catarina	University of Miami Miller School of Medicine	https://ensaiosclinicos.gov.br/rg/RBR-7zbxq5	<NULL>	Diagnosis of Parkinson&apos;s disease; stages I through IV according to the Scale of HOEHN and YAHR; individuals correctly performing the drug treatment.	Individuals unable to practice physical exercises; Serious cognitive alterations; contraindication to any of the outcome tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-10m9tg2r	A pilot randomised controlled trial of an Acceptance and Commitment Therapy group intervention for family carers of people with dementia	Recruiting	Intervention	2022-08-01	<NULL>	<NULL>	5525	Family Carers of people with dementia: assessing the efficacy of an Acceptance and Commitment Therapy group intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-10	Universidade Federal de Minas Gerais	University of East Anglia	https://ensaiosclinicos.gov.br/rg/RBR-10m9tg2r	<NULL>	Be a family carer of a relative with a clinical diagnosis of dementia; aged 18 and over; identifying oneself as a primary carer in their family; providing a minimum of 28 hours of care each week; having a minimum of four years of formal education; having access to the internet and a device to access online sessions; scoring nine or higher on the Generalised Anxiety Disorder (GAD-7) questionnaire.	Currently receiving psychological therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-6dn3mm	A pilot study evaluating the efficacy of the 204 LEDs helmet in men with initial vertex hair loss	Recruiting	Intervention	2019-07-04	<NULL>	<NULL>	2801	A pilot study evaluating the efficacy of the 204 LEDs helmet in men with initial vertex Androgenetic Alopecia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-06	Every Eletroeletrônica Importação e Exportação LTDA – EPP	Every Eletroeletrônica Importação e Exportação LTDA – EPP	https://ensaiosclinicos.gov.br/rg/RBR-6dn3mm	<NULL>	Male volunteers; with shaved hair or who agree to shave the hair for maximum 1 mm length in all interest areas for tricoscopy analyzes; Age between 18 and 65 years, with clinical and tricoscopic diagnosis of androgenic alopecia grade III vertex and IV of Hamilton-Norwood; who attended at the dermatology clinic of the “Hospital Regional da Asa Norte”; Have signed the free and informed consent form; Have signed the authorization for use of image for research, medical publication and dissemination purposes.	Carriers of: uncompensated thyroid disease; anemia or ferritin below 20 mcg/L; FAN with titration greater than 1/320 of any pattern except nuclear fine dot pattern; VDRL with titration greater than 1/8; Carriers of other forms of non-androgenetic alopecia, such as: telogen effluvium, alopecia areata, lichen planopilaris, discoid lupus of the scalp, trichotillomania, among others; Scar at the site of the tricoscopy; Individuals with white or very light hair in color that make difficult the tricoscopic analysis and that do not accept to dye all their hair for the global and tricoscopic pictures; Individuals with hair dye allergy when necessary to use it; Individuals who are using drugs with androgenic or anti-androgenic properties, chemotherapeutic agents, finasteride or others 5-alpha-reductase inhibitors; Individuals who have performed any type of treatment for androgenetic alopecia in the last 6 months, such as finasteride, minoxidil, corticosteroids, 17-alpha-estradiol, ketoconazole, laser/LED, microneedling; Individuals who have had any flavivirus disease in the last 6 months have undergone any type of major surgery requiring anesthesia with sedation, large weight loss or other known cause of telogen effluvium; as well as at any time have undergone bariatric surgery or hair transplantation at the tricoscopy site; Individual has not used the device under study for at least 4 different days per week or if it has not been used for more than 7 consecutive days and also used more than 7 times per week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-4xgwxb	A pilot study for care for trans men	Not yet recruiting	Observational	2020-01-03	<NULL>	<NULL>	3325	Humanization of trans men`s care: A pilot study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Mauro Schechter	Projeto Praça Onze	https://ensaiosclinicos.gov.br/rg/RBR-4xgwxb	<NULL>	female gender (at birth); Able to provide written informed consent;Aged 18 to 65 years older; Identify with the male Use of masculinizing hormones	male gender at birth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-3kzxsf	A placebo versus study medication trial study for verification of improving survival in metastatic colorectal cancer patients.	Recruiting	Intervention	2016-09-12	<NULL>	<NULL>	999	A phase III double-bblinded, placebo controlled study of xilonix™ for improving survival in metastatic colorectal cancer.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-09-29	XBiotech USA Inc	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-3kzxsf	<NULL>	Subjects with pathologically confirmed colorectal carcinoma that is metastatic or unresectable and which is refractory to standard therapy; to be considered refractory, a subject must have experienced progression (or intolerance) after treatment with at least all of the following agents: oxaliplatin, irinotecan, flouropyrimidine, and cetuximab or panitumumab if KRAS (retrovirus-associated DNA (desoxinucleic acid) sequences isolated from Kirsten murine sarcoma viruses) wildtype; subjects will not be treated with any radiation, chemotherapy, or investigational agents while enrolled in this protocol;  Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2; at least 2 weeks since the last previous cancer treatment including: chemotherapy, radiation therapy, immunotherapy, surgery, hormonal therapy, or targeted biologics and 4 weeks for patients who received treatment immediately prior to the study with anti-IL-1 (anti-interleukin 1) or anti-TNF (tumor necrosis factor) agents; age 18 years or older, male or female subjects; serum potassium and magnesium levels within Central Lab normal limits. Total serum calcium or ionized calcium level must be greater than or equal to the lower limit of normal. Subjects with low potassium, calcium and magnesium levels may be replenished to allow for protocol entry; adequate renal function; adequate hepatic function; adequate bone marrow function; for women of childbearing potential (WOCBP), a negative serum pregnancy test result at screening and monthly thereafter; for women who are not postmenopausal (24 months of amenorrhea) or surgically sterile (absence of ovaries and/or uterus): agreement to use adequate methods of contraception, during the treatment period and for at least 1 month after the last dose of study drug; signed and dated institutional review board (IRB)-approved informed consent before any protocol-specific screening procedures are performed; patients enrolled must, in the investigator’s judgment, be healthy enough to stay on the clinical trial for three months.	Mechanical obstruction that would prevent adequate oral nutritional intake; serious uncontrolled medical disorder, or active infection, that would impair the ability of the patient to receive protocol therapy; uncontrolled or significant cardiovascular disease; dementia or altered mental status that would prohibit the understanding or rendering of informed consent; subjects who have not recovered from the adverse effects of prior therapy at the time of enrollment to grade equal or lower than 1, excluding alopecia and grade 2 neuropathy; immunocompromised subjects; history of hepatitis B or C; history of tuberculosis; receipt of a live (attenuated) vaccine within 1 month prior to screening; subjects with history of hypersensitivity to compounds of similar chemical or biologic composition of xilonix; women who are pregnant or breastfeeding; WOCBP or men whose sexual partners are WOCBP who are unwilling or unable to use an acceptable method of contraception for at least 1 month prior to study entry, for the duration of the study, and for at least 1 month after the last dose of study medication; weight loss higher than 20% in the previous 6 months; history of progressive multifocal leukoencephalopathy or other demyelinating disease; subjects on immunosuppressive therapy, including transplant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-2x8xh8	A placebo-controlled study of Ipatasertib in combination with Atezolizumab and Paclitaxel as a treatment for patients with advanced breast cancer	Recruiting	Intervention	2019-10-25	<NULL>	<NULL>	3131	A phase III, double-blind, placebo-controlled, randomized study of Ipatasertib in combination with Atezolizumab and Paclitaxel as a treatment for patients with locally advanced unresectable or metastatic triple-negative breast cancer	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-07-17	Hospital Perola Byington	Hospital Perola Byington	https://ensaiosclinicos.gov.br/rg/RBR-2x8xh8	<NULL>	Women or men with 18 to 65 years with locally advanced unresectable or metastatic triple-negative adenocarcinoma of the breast who have not received prior systemic chemotherapy in this setting may be eligible for this study.  In patients with BRCA-associated tumors, platinum chemotherapy as potentially the preferred treatment option should be taken into consideration when determining whether this study may be appropriate for these patients.  Patients may have received prior chemotherapy in the neoadjuvant or adjuvant setting if treatment was completed at least 12 months prior to randomization. Locally advanced unresectable disease must not be amenable to resection with curative intent.  Patients must have sufficient tumor tissue and comply with all eligibility criteria to be enrolled. Signature (s) of Free and Informed Consent (s) signed; Women or men, aged 18 or over at the moment of signing the Informed Consent Term; Provision and ability to conduct all assessments related to the study, including PRO assessments, in the investigator&apos;s judgment; Measurable disease according to RECIST (Pre-irradiated lesions may be considered as measurable disease only if the progressive disease has been unequivocally documented at that location since the radiation.); Functional Capacity of 0 or 1 according to the Collaboration Group in East-American Oncology; Adequate hematological and organ function within 14 days before the first treatment of the study on Day 1 of Cycle 1; Life expectancy of at least 6 months; For women of childbearing potential: agree to remain abstinent or use contraception and agree to refrain from donating eggs; For men agree to remain abstinent (refrain from heterosexual intercourse) or use contraceptive methods and agree to refrain from donating sperm, a histologically documented triple-negative breast adenocarcinoma that is locally advanced or metastatic and is not amenable to resection with curative intent;  Dispatch of a formalin-fixed and paraffin-embedded tumor tissue block (FFPE) or at least 15 freshly cut serial tumor blades not stained from the most recently collected tumor tissue (for PD-L1 status and other secondary and exploratory assessments required by the Protocol). Cytology or FNA samples will not be acceptable. Tumor tissue of bone metastases that is submitted to decalcification will not be acceptable; If a more recent sample is insufficient or unavailable, a patient may still be eligible if the patient can provide a block of tissue (preferred) or at least 15 unblotted serial slides of an older tumor archived tissue or is willing to consent and undergo an extra thick or excisional needle biopsy of the non-target lesion on pre-treatment (if it is accessible and the biopsy can be safely obtained). In general, at least three biopsies per thick needle will be required;	Inability to adhere to study and follow-up procedures; History of malabsorption syndrome or other condition that would interfere with enteral absorption or result in inability or unwillingness to swallow pills; Active infection requiring systemic antimicrobial treatment (including antibiotics, antifungal agents and antiviral agents); Known HIV infection (there should be a negative HIV test at screening); A clinically significant history of liver disease consistent with Child-Pugh B or C Class including active viral hepatitis or other hepatitis, current drug / drug or alcohol or cirrhosis abuse; Current treatment with antiviral therapy for HBV; Large surgical procedure, open biopsy or significant traumatic injury within 28 days prior to Cycle 1 Day 1 or anticipated need for a large surgical procedure during the study; Placement of a vascular access device will not be considered a major surgery; Pregnancy or lactation or intention to become pregnant during the study or within 28 days after the final dose of ipatasertibe / placebo, 5 months after the final dose of atezolizumab / placebo and 6 months after the final dose of paclitaxel, whichever occurs later; Class II, III or IV heart failure according to the New York Heart Association, ejection fraction left ventricle less than 50% or active ventricular arrhythmia requiring medication; Unstable angina present or history of myocardial infarction within 6 months before Day 1 of Cycle 1; Congenital long QT syndrome or QT interval corrected by the Fridericia formula (QTcF) at screening more than 480 ms; History or presence of an abnormal ECG that is clinically significant in the investigator&apos;s opinion (including complete left bundle branch block, second or third degree heart block or evidence of prior myocardial infarction); Need for chronic corticosteroid therapy more than 10 mg prednisone per day or equivalent dose of other anti-inflammatory corticosteroids or immunosuppressive agents for a chronic disease; Any other disease, metabolic dysfunction, physical examination findings, or clinical laboratory findings that in the investigator&apos;s opinion lead to reasonable suspicion of a disease or condition that contravenes the use of a investigational drug or that may affect the interpretation of the results or puts the patient at high risk for treatment complications; History of or known presence of brain or spinal metastases as determined by computed tomography (CT) or magnetic resonance imaging (MRI) evaluation during screening or previous radiographic evaluations; Any previous systemic therapy for locally advanced or metastatic triple inoperable breast adenocarcinoma; Patients who have received palliative radiotherapy for peripheral sites;Pleural effusion, pericardial effusion or uncontrolled ascites; Known hypersensitivity or contraindication to any component of the study treatments, including the excipient of paclitaxel, macrogolglycerol ricinoleate; Peripheral neuropathy Grade greater than or equal to 2; History of Type I or Type II diabetes mellitus requiring insulin; History of or autoimmune disease or active immunodeficiency including, but not limited to, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener&apos;s granulomatosis, Sjögren&apos;s syndrome, Guillain- Barré or multiple sclerosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-10z7j4jd	A portable irradiation device for the improvement of photodinamic therapy	Recruitment completed	Observational	2021-12-29	<NULL>	<NULL>	7846	A portable device for photodynamic Therapy to improve treatment reducing the time under treatment at the hospital	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-01-01	Instituto de Física de São Carlos	Hospital Amaral Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-10z7j4jd	<NULL>	both sexes; older than 18  years; basal cell carcinoma lesions with less than 2 cm diameter; patients presenting multiple lesions can be included if the lesions have less than 2 cm diameter.	allergies from any compound of the formula; infiltrative or sclerodermiform basal cell carcinoma, as well as other skin cancers like squamous cell carcinoma or melanoma;  patients with pophyria diagnosis; basal cell carcinoma lesions larger than 2 cm; patients under 18; pregnant or lactating women; women at the childbearing age; photossensitive diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-6cf4xh	A preliminary study for testing a new drug to kidney stones treatment	Not yet recruiting	Intervention	2015-08-18	<NULL>	<NULL>	592	A Phase I/II clinical trial for evaluating safety and efficacy of an innovative medicine to nephrolithiasis treatment	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2016-01-04	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Apis Flora industrial e comercial limitada	https://ensaiosclinicos.gov.br/rg/RBR-6cf4xh	<NULL>	18 to 55 years old; male; any race, healthy volunteers; non-smoking; without drug addiction, use of alcohol or medicines.	Female; elderly (age&gt;55years); any clinically detectable disease, found on clinical history or physical examination; abnormal ECG (except unspecific ventricular repolarization changes, sinus brady/tachycardia); abnormal laboratory tests in blood cells count, kidney, reproductive, metabolic or hepatic function; participation in clinical trials in the last year; history of allergic reaction to medicines; use of any drug one week before the beginning or during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-6mk8r3	A Program of Health Promotion and Prevention of Damage on Pelvic Floor in Public Workers	Data analysis completed	Observational	2020-09-24	<NULL>	<NULL>	4287	A Program of Health Promotion and Prevention of damage on pelvic floor  in public workers of a brazilian public University	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-02-20	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6mk8r3	<NULL>	The inclusion criteria (IC) will be women between 20 and 60 years old; public workers of university and who aim to participate.	The exclusion criteria (EC) will be women who have some deslocation issue that interfere from going and / or carrying out the activities of the interventions; women who are already doing medical treatment, physical therapy or any other treatment directed to the pelvic floor dysfunctions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-2d2j5wp	A proposal for an ecological assessment of the affective response to increasing and decreasing intensity physical exercise in adolescents	Not yet recruiting	Intervention	2025-05-16	<NULL>	<NULL>	8007	The affective response to physical exercise of different intensities in adolescents	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-05-19	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2d2j5wp	<NULL>	Healthy volunteers; both genders; aged between 11 and 17 years; agree to participate in the study by signing the consent forms by their guardian and assent by the participant	Self-report of diagnosis of psychiatric disorders; self-report of use of alcohol or drugs; physical inability to perform physical exercise; participant who does not participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-3vmkt2	A Prospective Single Arm, Open-label, International, Multicenter Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Atazanavir (ATV) Powder Boosted with Ritonavir (RTV) Liquid with an Optimized NRTI Background Therapy, in HIV Infected Pediatric Patients Greater Than or Equal to 3 Months to Less Than 6 Years. (Pediatric Atazanavir International Clinical Evaluation: the PRINCE I study)	Recruitment completed	Intervention	2011-06-13	<NULL>	<NULL>	225	A Prospective Single Arm, Open-label, International, Multicenter Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Atazanavir (ATV) Powder Boosted with Ritonavir (RTV) Liquid with an Optimized NRTI Background Therapy, in HIV Infected Pediatric Patients Greater Than or Equal to 3 Months to Less Than 6 Years. (Pediatric Atazanavir International Clinical Evaluation: the PRINCE I study)	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2010-11-01	Bristol-Myers Squibb	Bristol-Myers Squibb	https://ensaiosclinicos.gov.br/rg/RBR-3vmkt2	<NULL>	HIV 1 infection diagnosed by protocol criteria. &gt;= 3 months to &lt; 5 years and 6 months of age at time of first treatment, and weight &gt; 5 to &lt; 25kg with any screening baseline plasma viral load. Antiretroviral naive and experienced. Screening HIV RNA &gt;= 1000 copies/mL. Must have genotypic sensitivity at screening to ATV and at least 2 NRTIs. NRTIs must be approved for pediatric use at the local country. Subjects must have documented genotypic and phenotypic sensitivity at screening to ATV (Fold Change in susceptibility &lt; 2.2) and to at least 2 NRTIs that are approved in their country.	Experienced subjects who received ATV or ATV/RTV at any time prior to study enrollment or who have prior history of 2 or more PI failures. Antiretroviral-naïve or experienced HIV-1 infected patients with contraindication to study medications. Family history of QTc interval syndrome, Brugada syndrome or right ventricular dysplasia or with a corrected QTc interval at screening of &gt; 440 ms. One of the following cardiac rhythm abnormalities documented on the screening ECG: First degree atrioventricular (AV) block as defined by protocol. Type I second degree AV block while awake, type II second degree AV block at any time, complete AV block at any time, or age-adjusted heart rate &lt; 2nd percentile). Use of Tenofovir.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-52f6h2	A protocol for an interventional study on the impact of transcutaneous parasacral nerve stimulation in children with functional constipation.	Recruiting	Intervention	2020-07-06	<NULL>	<NULL>	4347	Evaluation of the study of transcutaneous electrical current in the lumbar region in children with intestinal constipation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Universidade Estadual Paulista Julio de Mesquita Filho - Unesp	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-52f6h2	<NULL>	"Patients aged 7 to 18 years; of both sexes; 
intestinal constipation"	Neurological and / or cognitive deficits; skin lesions in the region where the electrodes are applied; changes in local sensitivity; presence of cardiac pacemaker; children with heart disease or cardiac arrhythmias; patients who present incomplete questionnaires; abandonment of the proposed electrostimulation treatment during the intervention period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-97mffm	A randomised controlled trial of a smartphone application for help oral hygiene	Not yet recruiting	Intervention	2020-02-10	<NULL>	<NULL>	3469	Mobile Health (mHealth) Intervention assessment for the treatment of periodontal diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Programa de Pós Graduação em Odontologia da Universidade Federal do Rio Grande do Sul	Mirian Paola Toniazzo	https://ensaiosclinicos.gov.br/rg/RBR-97mffm	<NULL>	"To be included:
volunteers with gingivitis and periodontitis;
non smokers;
both genders;
age between 18 and 60 years;
 Individuals must have their own cell phone handset with internet access;
be literate in mHealth;
have a visible plaque percentage greater than or equal to 30%;
have a percentage of gingival bleeding greater than or equal to 30%;
Clinical insertion loss greater than or equal to 3 mm in two nonadjacent teeth;
bore depth greater than or equal to 4 mm in two or more teeth;
At least 12 teeth present."	"The following exclusion criteria will be considered: 
patients who used antibiotics or anti-inflammatory drugs in the last 6 months prior to the study; 
who have any physical condition that impairs their motor skills; 
who are wearing orthodontic braces; 
 smokers."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-62wvhp	A randomized clinical study using Mta for Endodontic Treatment as a material in milk teeth	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2485	Randomized clinical assay of use the Mta in Pulpar Therapy of deciduous teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-06	Angelus Industria de Produtos Odontológicos S/A	CCS - COU - Programa de Pós-Graduação em Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-62wvhp	<NULL>	Healthy children;molar teeth with deep carious lesion;provoked and non-persistent pain;maximum root resorption of up to 2/3 root;restorative tooth;tooth that allows absolute isolation	Primary molars with percussion sensitivity, spontaneous and persistent pain, interradicular bone loss, internal resorption, less than 2/3 of root, edema, fistula, abscess, pulp calcifications, pathological mobility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-9chxvg	A randomized clinical study using Mta for the treatment of canal on milk teeth	Recruiting	Intervention	2019-06-17	<NULL>	<NULL>	2766	Randomized clinical assay of use the Mta in Pulpar Therapy of deciduous teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Angelus Industria de Produtos Odontológicos S/A	"Universidade Estadual Paulista  ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-9chxvg	<NULL>	Healthy children;upper and lower incisors or deciduous lower molars with deep carious lesion reaching the root pulp;spontaneous and persistent pain, dark red bleeding of difficult control; maximum resorption up to 2/3 of the root;restorable tooth;pulp exposure with clinical evidence of necrotic pulp or irreversible pulpitis.	Upper and lower incisors or deciduous lower molars with internal resorption;fistula near the gingival margin;Pulmonary calcifications; pathological mobility;periapical bone rarefaction with evidence of continuity solution in the crypt of the permanent successor germ.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-36w269	"A Randomized Double-Blind Phase 3 Trial Comparing Docetaxel Combined with
Dasatinib to Docetaxel Combined with Placebo in Castration-Resistant Prostate Cancer"	recruitment completed	Intervention	2011-06-13	<NULL>	<NULL>	2	"A Randomized Double-Blind Phase 3 Trial Comparing Docetaxel Combined with
Dasatinib to Docetaxel Combined with Placebo in Castration-Resistant Prostate Cancer"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2010-01-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-36w269	<NULL>	"Subjects must have signed an informed consent document stating that they
understand the investigational nature of the proposed treatment.
History of histologically diagnosed prostate cancer.
Evidence of metastatic disease by any 1 of the following modalities: CT scan,
MRI, bone scan, or skeletal survey.
Evidence of progression, as defined by 1 of the following:
  Rising PSA values at least 1 week apart with the final value being &gt;= 2 ng/mL,or
  Progression of measurable nodal or visceral disease:
   Nodal lesions must be &gt;= 20 mm
   Visceral lesions must be measurable per RECIST criteria, or
   Two or more new lesions appearing on a bone scan compared with a prior
scan, or
   Local recurrence in the prostate or prostate bed.
Maintaining castrate status: Subjects who have not undergone surgical
orchiectomy should have received and continue on medical therapies [eg,
gonadotropin releasing hormone analogs (GnRH/LHRH analogs)] to maintain
castrate levels of serum testosterone &lt;= 50 ng/dL (1.7 nmol/L).
ECOG Performance Status 0 - 2.
At least 4 weeks since major surgery, radiotherapy, and an investigational agent.
At least 8 weeks since radioisotope therapy (eg, Strontium-89, Samarium-153 or
similar agents).
Recovery from local primary therapy of surgery or radiation.
 Required initial laboratory values:
 WBC &gt;= 3,000/mm3.
 ANC &gt;= 1,500/mm3.
 Platelet count &gt;= 100,000/mm3.
 Creatinine &lt;= 1.5 x upper limits of normal.
 Bilirubin &lt;= upper limit of normal (does not apply for subjects with Gilbert’s
Disease).
 SGOT (AST) &lt;= 2.5 x upper limits of normal.
 SGPT (ALT) &lt;= 2.5 x upper limits of normal.
Men only, at least 18 years old."	"Women.
Sexually active fertile men not using effective birth control if their partners are WOCBP.
Subjects with active brain metastases or leptomeningeal metastases are excluded
from this clinical trial.
Clinically significant cardiovascular disease, including myocardial infarction or
ventricular tachyarrhythmia within 6 months, prolonged QTc &gt; 450 msec, ejection
fraction (EF) &lt; 40% or major conduction abnormality, unless a cardiac pacemaker
is present.
Pleural or pericardial effusion of any CTC grade.
Peripheral neuropathy CTC Grade &gt;= 2.
Subjects with a “currently active” second malignancy other than non-melanoma
skin cancers are not to be enrolled into the study. Subjects are not considered to
have a “currently active” malignancy if they have completed therapy and are now
considered (by their physician) to be at less than 30% risk for relapse.
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
HIV-positive subjects receiving combination anti-retroviral therapy.
History of allergic reactions attributed to compounds of similar chemical or
biologic composition to the investigational agents.
Subjects may not be receiving any other investigational agents for the treatment of
prostate cancer.
No prior cytotoxic chemotherapy in the metastatic setting, with the exception of
estramustine.
Subjects may continue on a daily multi-vitamin but all other herbal, alternative
and food supplements (eg, PC-Spes, Saw Palmetto, St John’s Wort) must be
discontinued before enrollment into the study.
Ketoconazole must be discontinued 4 weeks prior to starting study therapy.
Anti-androgens should be discontinued prior to starting study therapy. Subjects
with a history of response to an anti-androgen and subsequent progression while
on that anti-androgen should be assessed for anti-androgen withdrawal response
for 4 weeks. Observation for anti-androgen withdrawal response is not necessary
for subjects who have never responded to anti-androgens.
Bisphosphonates must not be initiated within 28 days prior to starting study
therapy.
QT prolonging agents strongly associated with torsade de pointes.
Prisoners or subjects who are involuntarily incarcerated.
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-48pb9h	A Randomized Double-Blinded Phase II Study of Carboplatin/Paclitaxel/CT-322 versus Carboplatin/Paclitaxel/Bevacizumab as First-Line Treatment for Recurrent or Advanced Non-Small Cell Lung Cancer with Non-Squamous Histology	recruiting	Intervention	2011-06-13	<NULL>	<NULL>	3	A Randomized Double-Blinded Phase II Study of Carboplatin/Paclitaxel/CT-322 versus Carboplatin/Paclitaxel/Bevacizumab as First-Line Treatment for Recurrent or Advanced Non-Small Cell Lung Cancer with Non-Squamous Histology	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2010-07-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-48pb9h	<NULL>	"Subjects must sign an informed consent prior to any study-related procedures.
 Histologically or cytologically confirmed, stage IIIB (malignant pleural effusion), stage IV or recurrent Non Small Cell Lung Cancer;
 Measurable disease by Response Evaluation Criteria In Solid Tumors guidelines, with at least 1 target lesion outside any previous radiotherapy field;
 Eastern Cooperative Oncology Group performance status &lt; 1;
 Life expectancy of at least 3 months;
 Accessible for treatment and follow-up. Subjects enrolled in this trial must be treated at the participating center(s).
 Willing to give a whole blood sample for the study of proteins and genetic polymorphisms in genes related to the Vascular Endothelial Growth Factor signaling pathway.
 Men and women, ages &gt;18 years.
Women of childbearing potential must be using an adequate method of contraception to avoid pregnancy throughout the study [and for up to 6 weeks after the last dose of investigational product] in such a manner that the risk of pregnancy is minimized.
Women of childbearing potential include any female who has experienced menarche and who has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Postmenopause is defined as:
Amenorrhea &gt; 12 consecutive months without another cause or 
• For women with irregular menstrual periods and on hormone replacement therapy (HRT), a documented serum follicle stimulating hormone level &gt; 35 International Units/mL
Women who are using oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
Women of childbearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 International Units/L or equivalent units of Human Chorionic Gonadotropin) within 72 hours prior to the start of investigational product."	"Women of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period [and for up to 6 weeks after the last dose of investigational product]
Women who are pregnant or breastfeeding 
Women with a positive pregnancy test on enrollment or prior to investigational product administration
Sexually active fertile men not using effective birth control if their partners are Women of childbearing potential.
Evidence of predominantly squamous-cell histology (mixed cell type tumors only)
Known central nervous system metastasis
Less than 28 days elapsed following major surgery 
Excessive risk of bleeding such as history of clinically significant bleeding diathesis or coagulopathy including platelet function disorder (eg, known hemophilia or von Willebrand disease) or acquired bleeding disorder within 12 months (eg, acquired anti-factor VIII antibodies)
Gross hemoptysis (&gt;= 1/2 tablespoon of red blood)
Subjects receiving therapeutic anticoagulation
Thrombotic or embolic cerebrovascular accident including transient ischemic attacks within the past 12 months
Uncontrolled hypertension (defined as systolic blood pressure &gt;150 mmHg or diastolic &gt; 90 mmHg, measured repeatedly at &gt;=2 visits despite adequate treatment with &gt;= 2 antihypertensive drugs)
Clinically significant cardiovascular disease, including (but not limited to) the following:
 Myocardial infarction within the past 6 months
 Unstable angina
 New York Heart Association class II-IV congestive heart failure
 Serious cardiac arrhythmia (eg ventricular arrhythmia, high-grade atrioventricular block), not controlled by medication or requiring medication which might interfere with regularity of study treatment
 Left ventricular ejection fraction below institutional lower limit of normal as measured by 2-dimensional echocardiogram or cardiac MUGA scan.
 History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months
 Serious non-healing wound, active peptic ulcer, non-healing bone fracture, or bleeding skin metastases
 Glomerulonephritis or other protein-wasting glomerulopathy
 Active clinically significant infection(&gt; Grade 2) requiring the use of antimicrobial agents, or that would otherwise, in the opinion of the investigator, interfere with the ability the subject to participate
 Any concurrent malignancy other than non-melanoma skin cancer, or carcinoma in-situ of the cervix
 Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent
 Any serious uncontrolled medical disorder that, in the opinion of the investigator, would impair the ability of the subject to receive study therapy.
Hemoglobin &lt;9.0 g/dL, Absolute Neutrophil Count &lt;1500 cells/mm3, Platelets &lt;100,000 cells/mm3
Serum creatinine &gt;1.5 mg/dL
Calculated creatinine clearance &lt;50 mL/min (using Cockcroft and Gault formula)
Urine protein/creatinine ratio &gt; 1
Serum total bilirubin &gt;1.5 times the institutional upper limit of normal, unless due to Gilbert’s disease
Alanine transaminase or aspartate aminotransferase &gt;2.5 times the institutional upper limit of normal (&gt;5 times upper limit of normal for subjects with documented liver metastases)
Serum amylase and lipase &gt;1.5 times the upper limit of normal
Known hypersensitivity to any of the investigational products or excipients, including Cremophor EL®
Any prior antineoplastic systemic regimens for NSCLC. Subjects must not initiate any concurrent antineoplastic therapy while on study.
Prisoners or subjects who are involuntarily incarceratedSubjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness

Eligibility criteria for this study have been carefully considered to ensure the safety of the study subjects and to ensure that the results of the study can be used. It is imperative that subjects fully meet all eligibility criteria."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-4d9cv7	A Randomized Study with the use of Melatonin as Complementary Therapy to the Regimen of Analgesia and Sedation in Intensive Care: Analysis of Serum Levels	Recruitment completed	Intervention	2018-12-12	<NULL>	<NULL>	3406	A Randomized Study with the use of Melatonin as Adjuvant to the Analgesic Regimen in Intensive Care: Analysis of Serum Levels	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-25	Faculdade de Medicina de São José do Rio Preto - FAMERP	Faculdade de Medicina de São José do Rio Preto - FAMERP	https://ensaiosclinicos.gov.br/rg/RBR-4d9cv7	<NULL>	Patients admitted to the ICU in the surgery postoperative, polytraumatized, with severe infection or sepsis, using analgesics and or sedatives, with the possibility of using the GIT within 48 h after admission to the ICU, both genders and above age of 18 years.	Patients considered unable to answer questionnaires, patients with a history of seizures, neurological or psychiatric diseases, sleep apnea, deaf or mute, with renal or hepatic failure, intestinal obstruction or other condition that would affect intestinal absorption, pregnancy, lactation and diseases autoimmune	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-2n9x58k	A randomized, controlled study on the use of antifoaming and mucolytic agents in preparation for upper digestive endoscopy	Terminated	Intervention	2024-12-19	<NULL>	<NULL>	7610	Use of mucolytics and antifoams in preparation for Upper Digestive Endoscopy diagnosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Instituto Hospital de Base do Distrito Federal	Instituto de Gestão Estratégica de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-2n9x58k	<NULL>	Outpatient care for diagnostic upper gastrointestinal endoscopy; age greater than or equal to 18 years; both sexes	Patients who did not sign the Informed Consent Form; those who had forms filled out incompletely; patients with malignant gastrointestinal tract diseases; and neurological diseases; with an indication of therapeutic procedures at the time of the examination; the presence of food residues in the esophagus or stomach	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-28gdtz	"A Randomized, Double-blind, Multi-center Phase III Study of Brivanib plus Best
Supportive Care (BSC) versus Placebo plus BSC in Subjects with Advanced
Hepatocellular Carcinoma (HCC) who have Failed or are Intolerant to Sorafenib"	recruitment completed	Intervention	2011-06-27	<NULL>	<NULL>	7	"A Randomized, Double-blind, Multi-center Phase III Study of Brivanib plus Best
Supportive Care (BSC) versus Placebo plus BSC in Subjects with Advanced
Hepatocellular Carcinoma (HCC) who have Failed or are Intolerant to Sorafenib"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2010-02-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-28gdtz	<NULL>	"Voluntary signed and dated written informed consent form in accordance with
regulatory and institutional guidelines obtained before the performance of any
protocol-related procedures not part of normal patient care.
Histologic or cytologic confirmed diagnosis of hepatocellular carcinoma.
Advanced disease defined as:
  Disease not eligible for surgical or loco-regional therapy or
 Disease progressive after surgical or loco-regional therapy
Patient has failed &gt;= 14 days of sorafenib treatment:
 Documented radiographic progression                       Documented symptomatic progression 
 Documented intolerance to sorafenib Cirrhotic status of Child-Pugh Class A or B with a score of 7).
Eastern Cooperative Oncology Group performance status 0, 1, 2 
Subjects who have a life expectancy of at least 8 weeks.
Accessible for treatment and follow-up.
Locoregional therapy must be completed at least 3 weeks prior to the baseline
scan; previously treated lesions are not selected as index lesions.
At lease one measurable untreated lesion. All subjects must have at least one
previously un-irradiated, bi-dimensionally measurable lesion by computerized tomography or magnetic resonance imaging scan &gt;= 20mm. Index lesions that are previously un-irradiated and are bi-dimensionally measurable by spiral CT scan to be &gt;= 10mm will be permitted.
 The lesion can be accurately measured bidimensionally according to WHO
criteria.
 The lesion has not been previously treated with surgery, radiation therapy,
radiofrequency ablation, percutaneous ethanol or acetic acid injection, or
cryoablation.
 Bone metastases are not considered measurable lesions.
Adequate hematologic function with absolute neutrophil counts &gt;= 1,500/mm3,
platelet count &gt;= 60 x 109/L, and hemoglobin &gt;= 8.5 g/dl.
Adequate hepatic function with serum total bilirubin &lt;= 3 mg/dl, serum albumin
&gt;= 2.8 g/dL and alanine aminotransferase and aspartate aminotransferase &lt;= 5 times the institutional upper limits of normal.
Amylase and lipase &lt; 1.5 times the institutional upper limit of normal.
Adequate renal function with serum creatinine &lt;= 2.0 mg/dl.
International normalized ratio (INR) &lt;= 2.3 or Prothrombin Time (PT) &lt;= 6
seconds above control.
Left ventricular ejection fraction (LVEF) &gt;= 50% as measured by 2-D
Echocardiogram.
Male or female subjects &gt;= 18 years of age.
Women of childbearing potential (WOCBP) must be using an adequate method
of contraception to avoid pregnancy throughout the study and up to 12 weeks
after the last dose of investigational product in such a manner that the risk of
pregnancy is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation,or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined as:
 Amenorrhea &gt;= 12 consecutive months without another cause or
 For women with irregular menstrual periods and on hormone replacement
therapy (HRT), a documented serum follicle stimulating hormone (FSH) level
&gt;= 35 mIU/mL.
Women who are using oral contraceptives, other hormonal contraceptives
(vaginal products, skin patches, or implanted or injectable products), or
mechanical products such as an intrauterine device or barrier methods
(diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing
abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
WOCBP must have a negative serum or urine  pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 12 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding.
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Sexually active fertile men not using effective birth control if their partners are WOCBP.
Brain metastasis or evidence of leptomeningeal disease.
Known fibrolamellar HCC or mixed cholangiocarcinoma and HCC.
Any encephalopathy.
Any ascites.
Bleeding esophageal or gastric varices within 2 months prior to inclusion.
Previous or concurrent cancer that is distinct in primary site or histology from
HCC, except cervical carcinoma in situ, treated basal cell carcinoma, superficial
bladder tumors (Ta, Tis &amp; T1). Any cancer curatively treated &gt; 5 years prior to
entry is permitted.
History of active cardiac disease:
 Uncontrolled hypertension which is defined as systolic blood pressure greater
than 150 mmHg or diastolic pressure greater than 90 mmHg despite optimal
medical management. Subjects with a history of persistent hypertension who
are receiving treatment with calcium channel blockers that are CYP3A4
substrates should be changed to an alternative antihypertensive medication.
 Congestive heart failure NYHA (New York Heart Association) class III and
IV 
 Active coronary artery disease, unstable or newly diagnosed angina or
myocardial infarction less than 12 months prior to study entry.
 Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta
blockers or digoxin.
 Valvular heart disease &gt;= Common Terminology Criteria for Adverse Events Grade 2.
QTc (Fridericia) &gt; 450 msec on two consecutive electrocardiograms. (baseline electrocardiogram should be
repeated if QTc is found to be &gt; 450 msec).
Thrombotic or embolic events within the past 6 months, such as a
cerebrovascular accident (including transient ischemic attacks), pulmonary
embolism.
Any other hemorrhage/bleeding event &gt; CTC AE Grade 3 within 4 weeks except
for esophageal or gastric varices 
Active infection, less than 7 days after completing systemic antibiotic therapy.
Psychiatric illness/social situations that would limit compliance with study
requirements.
History of non-healing wounds or ulcers, or bone fractures within 3 months of fracture.
Major surgical procedure, open biopsy, or significant traumatic injury less than 3
weeks or those who receive minor surgical procedures (eg core biopsy or fine
needle aspiration) within 1 week.
History of organ allograft or on an allograft waiting list.
Vena cava thrombosis or occlusion.
Portal-caval shunts.
Inability to swallow tablets or untreated malabsorption syndrome.
Pre-existing thyroid abnormality with thyroid function that cannot be maintained
in the normal range with medication.
History of human immunodeficiency virus (HIV) infection.
Substance abuse, medical, psychological or social conditions that may interfere
with the patient’s participation in the study or evaluation of the study results.
Any medical condition that is unstable or which could jeopardize the safety of
the patient and his/her compliance in the study.
Active, untreated hepatitis B.
Positive pregnancy test.
Hyponatremia with sodium &lt; 130 mmol/L.
Baseline serum potassium &lt; 3.5 mmol/L (potassium supplementation may be
given to restore the serum potassium above this level prior to study entry).
Known or suspected history of allergy to brivanib or any agents given in
association with this trial.
Prior use of any systemic anti-cancer chemotherapy or targeted agents for HCC
except for sorafenib (prior loco-regional treatment including TACE is allowed).
Prior immunotherapy for HCC.
Concomitant treatment with rifampin (and its analogues), and St John’s Wort.
Prior use of systemic investigational agents for HCC (except for sorafenib).
Radiotherapy within 4 weeks prior to start of study drug.
Required anticoagulation therapy with an agent such as warfarin or heparin.
Required chronic anti-platelet therapy (aspirin at dose &gt;= 300 mg/day, clopidogrel
at dose &gt;= 75 mg/day).
Prisoners or subjects who are involuntarily incarcerated.
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-84sdd6	A Randomized, Double-blind, Multi-center Phase III Study of Brivanib versus Sorafenib as First-line Treatment in Patients with Advanced Hepatocellular Carcinoma	recruiting	Intervention	2011-06-27	<NULL>	<NULL>	5	A Randomized, Double-blind, Multi-center Phase III Study of Brivanib versus Sorafenib as First-line Treatment in Patients with Advanced Hepatocellular Carcinoma	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2010-05-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-84sdd6	<NULL>	"Voluntary signed and dated written informed consent form in accordance with
regulatory and institutional guidelines obtained before the performance of any
protocol-related procedures not part of normal patient care.
Histologic or cytologic confirmed diagnosis of HCC.
Advanced HCC
 disease not eligible for surgical and / or locoregional therapies
 progressive disease after surgical and / or locoregional therapies
Child-Pugh Class A 
ECOG performance status 0-1 
Life expectancy of at least 12 weeks
Accessible for treatment and follow-up
Locoregional therapy must be completed at least 3 weeks prior to the baseline
scan; previously treated lesions are not to be selected as target lesions.
At lease one measurable untreated lesion. All subjects must have at least one
previously un-treated, uni-dimensionally measurable lesion by CT or MRI scan &gt;=
20mm. Target lesions that are previously un-treated and are uni-dimensionally
measurable by spiral CT scan to be &gt;= 10mm will be permitted.
 The lesion can be accurately measured uni-dimensionally according to RECIST criteria
 The lesion has not been previously treated with surgery, radiotherapy, and /or
locoregional therapy (eg: radiofrequency ablation (RFA), percutaneous
ethanol or acetic acid injection (PEI / PAI), transcatheter arterial
chemoembolization (TACE) or cryoablation, etc.)
 Bone metastases are not considered measurable lesions.
Adequate hematologic function with absolute neutrophil counts &gt;= 1,500/mm3,
platelet count &gt;= 60 x 109/L, and hemoglobin &gt;= 8.5 g/dL
Adequate hepatic function with serum total bilirubin &lt;= 3 mg/dL, serum albumin
&gt;= 2.8 g/dL and ALT and AST &lt;= 5 times the institutional upper limits of normal
Amylase and lipase &lt;= 1.5 times the institutional upper limit of normal
Adequate renal function with serum creatinine &lt;= 2.0 mg/dL
International normalized ratio (INR) &lt;= 2.3 or Prothrombin time (PT) &lt;= 6 seconds
above control
Left ventricular ejection fraction (LVEF) &gt;= 50% as measured by 2-D Echocardiogram
All laboratory test finding should be stable within the range listed in 3a) - 3f)
without continuous supportive treatment, such as blood transfusion, coagulation
factors and / or platelet infusion, red / white blood cell growth factor
administration, albumin infusion, ursodeoxycholic acid, or drug treatment for
lowering liver enzyme / bilirubin, etc
Men and women, ages 18 or older
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 12 weeks
after the last dose of investigational product in such a manner that the risk of
pregnancy is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined as:
   Amenorrhea &gt;= 12 consecutive months without another cause or
   For women with irregular menstrual periods and on hormone replacement
therapy (HRT), a documented serum follicle stimulating hormone (FSH) level
&gt; 35 mIU/mL
Women who are using oral contraceptives, other hormonal contraceptives (vaginal
products, skin patches, or implanted or injectable products), or mechanical
products such as an intrauterine device or barrier methods (diaphragm, condoms,
spermicides) to prevent pregnancy, or are practicing abstinence or where their
partner is sterile (eg, vasectomy) should be considered to be of childbearing
potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 12 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Sexually active fertile men not using effective birth control if their partners are WOCBP.
Brain metastasis or evidence of leptomeningeal disease
Known fibrolamellar HCC or mixed cholangiocarcinoma and HCC
History of encephalopathy
Ascites
Evidence of portal hypertension with bleeding esophageal or gastric varices
within the past 2 months
Main portal vein* or vena cava thrombosis or occlusion.
* Main portal vein is defined as the part of the portal vein between the inferior vena cava and the first bifurcation into the left and right vein. It is usually located in the porta hepatis.
Previous or concurrent cancer that is distinct in primary site or histology from
HCC, except cervical carcinoma in situ, treated basal cell carcinoma, superficial
bladder tumors (Ta, Tis &amp; T1). Any cancer curatively treated &gt; 5 years prior to
entry is permitted.
History of active cardiac disease:
  Uncontrolled hypertension which defined as systolic blood pressure greater
than 150 mmHg or diastolic pressure greater than 90 mmHg despite optimal
medical management
  Congestive heart failure NYHA (New York Heart Association) class 3 and 4
  Active coronary artery disease, unstable or newly diagnosed angina or myocardial infarction less than 12 months prior to study entry
  Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta
blockers or digoxin
Valvular heart disease &gt;= CTCAE Grade 2
QTc (Fridericia) &gt; 450 msec on two consecutive ECGs. (baseline ECG should be
repeated if QTc is found to be &gt; 450 msec)
Thrombotic or embolic events within the past 6 months, such as a cerebrovascular
accident (including transient ischemic attacks), pulmonary embolism
Any other hemorrhage/bleeding event &gt;= CTCAE Grade 3 within 4 weeks except
for esophageal or gastric varices
Active infection, less than 7 days after completing systemic antibiotic therapy
Active, untreated hepatitis B
Psychiatric illness/social situations that would limit compliance with study
requirements
History of non-healing wounds or ulcers, or bone fractures within 3 months of
fracture
Major surgical procedure, open biopsy, or significant traumatic injury less than 3
weeks or those who receive minor surgical procedures (eg core biopsy or fine
needle aspiration) within 1 week
History of organ allograft or on an allograft waiting list
Portal-caval shunts
Inability to swallow tablets or untreated malabsorption syndrome
Pre-existing thyroid abnormality with thyroid function that cannot be maintained
in the normal range with medication
History of human immunodeficiency virus (HIV) infection
Substance abuse, medical, psychological or social conditions that may interfere
with the patient’s participation in the study or evaluation of the study results.
Any medical condition that is unstable or which could jeopardize the safety of the
patient and his/her compliance in the study.
Positive pregnancy test
Baseline serum sodium &lt; 130 mmol/L
Baseline serum potassium &lt; 3.5 mmol/L (potassium supplementation may be
given to restore the serum potassium above this level prior to study entry)
Known or suspected history of allergy to brivanib or sorafenib or any agents
given in association with this trial
Prior use of any systemic anti-cancer chemotherapy, immunotherapy or molecular
targeted agents for HCC
Concomitant treatment with rifampin (and its analogues), or St John’s wort
Prior use of systemic investigational agents for HCC
Radiotherapy within 4 weeks prior to start of study drug
Required anticoagulation therapy with an agent such as coumadin, warfarin or
heparin
Required chronic anti-platelet therapy (aspirin at dose &gt;= 300 mg/day, clopidogrel
at dose &gt;= 75 mg/day)
Prisoners or subjects who are involuntarily incarcerated
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-2n9nhj	A school-based intervention to improve sense of coherence and children&apos;s oral health related quality of life	Recruitment completed	Intervention	2016-09-08	<NULL>	<NULL>	985	A school-based intervention to improve sense of coherence and children&apos;s oral health related quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-2n9nhj	<NULL>	Children enrolled in the fourth and fifth years in the selected schools.	Children intellectually and physically uncapable of responding to the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-9s6tc8	A short course on Mindfulness via mobile app to reduce Stress and Anxiety in university students	Not yet recruiting	Intervention	2020-04-22	<NULL>	<NULL>	3764	A brief Mindfulness intervention with mobile App for reducing Stress and Anxiety in university students: Protocol for randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal da Paraíba - UFPB	Universidade Federal da Paraíba - UFPB	https://ensaiosclinicos.gov.br/rg/RBR-9s6tc8	<NULL>	Volunteers of both genders between eighteen and thirty five years old; being a university student; reside in Brazil; have internet access and a cell phone with Android; be willing to download and use the Neurosaúde application on your cell phone; achieve a score greater than 0 in the symptoms of anxiety and stress measured by the subscales of stress and anxiety of the Depression, Anxiety and Stress Scale.	Volunteers who have already adopted a frequent practice of mindfulness in the past six months; who are using some type of psychotropic medication or undergoing psychological treatment during the intervention period; have a diagnosis of psychiatric or neurological illness, such as schizophrenia, borderline, panic disorder, post-traumatic stress disorder; have severe or extremely severe symptoms of depression as measured by the depression subscale of the Depression, Anxiety and Stress Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-7yncpn6	A study about the effect of a telephone call on the quality of Bowel Preparation	Recruiting	Intervention	2021-06-28	<NULL>	<NULL>	4766	A randomized clinical trial about the impact of a Telephone Call on the quality of Bowel Preparation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-19	Faculdade de Ciências Médicas de Minas Gerais	Clínica Gastrocenter - Instituto de Cirurgia e Gastrenterologia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-7yncpn6	<NULL>	Female and male patients; over 18 years old	Incomplete cecal intubation; hypersensitivity reactions to the use of lactulose; diabetes; lactose intolerance; hemicolectomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-3d296r	A study comparing maintenance and resection of retropatellar fat in the knee prosthesis	Recruiting	Intervention	2018-02-26	<NULL>	<NULL>	1659	Comparative study between maintenance and resection of retropatellar fat pad in total knee arthroplasty; Clinical functional evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-12	Universidade Federal de Minas Gerais	Hospital Universitario Ciencias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-3d296r	<NULL>	Voluntary patients who spontaneously accept and sign the Term of Free and Informed Consent, the TCLE, after succinct explanation by the researcher; above 55 years; both sexes; patients with osteoarthrosis, primary or secondary to osteonecrosis, or vicious fracture consolidation; committed to perform the standard protocol of postoperative rehabilitation.	Voluntary patients with inflammatory joint disease; with a low preoperative patella, diagnosed radiologically by the Insall-Salvati index; with knee flexion above 15 degrees and limitation of flexion above 90 degrees, preoperatively.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-4f6sh5	A study for evaluation of efficacy and safety of medicine for adult obesity treatment	Not yet recruiting	Intervention	2015-04-14	<NULL>	<NULL>	445	Prospective study, parallel, double-blind, multicenter, for evaluation of efficacy and safety of Orlistat 60mg for adult obesity treatment compared to Orlistat 120mg	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-01-15	Marcio Antonio Pereira Clinica Médica de Endocrinologia LTDA	Marcio Antonio Pereira Clinica Médica de Endocrinologia LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4f6sh5	<NULL>	Signed Informed Consent; Adults Male and Female over 18 years old; Obesity (body mass index equal or greater 25kg/m2);	Pregnancy and Lactation or women without effective contraception;Patients with Relevant chronic degenerative diseases;Obesity associated to genetic syndrome or other diseases;Patients with a history of hospitalization for decompensated diabetes in the last 6 months;Psychiatric disorders;Alcoholism: consumption of more than 3 doses of distillate, or any alcoholic drink daily; History of alimentary disorders, for example: bulimia; Use of anorectics, herbal and / or any drug (s) with or without approved indication for weight loss in the last 30 days; Use of drugs or laxatives for constipation in the last 30 days; Any history of Inflammatory Bowel Disease; History of acute diarrhea (viral or bacterial) in the last 30 days or chronic diarrhea; Patients using cyclosporine, amiodarone, dicumarinic; Prior bariatric surgery; History of anemia; Hemoglobinopathies and coagulopathy; History of cancer in the past five years; Use of corticosteroids, oral or injectable, in the last 30 days; People Related to investigators, family, employees of the sponsor or linked to the study center; Have participated in another study in the last two months; Patients who have no ability to observe / record the occurrence of gastrointestinal events.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-105nyj86	A study of a new primaquine 5 mg formulation in healthy volunteers	Data analysis completed	Intervention	2021-06-09	<NULL>	<NULL>	4736	Bioavailability study of two formulations of Primaquine	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-07-21	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-105nyj86	<NULL>	"Men,
Non-pregnant and non-breastfeeding women
Within the age range 18 to 50 years old
Body Mass index range 19 to 28,5 Kg/m2
Health volunteers
Signed Informed Consent"	"Hypersensibility to the drug (primaquine): Previous pathologies that could influence the absorption distribution or excretion of the drug; Positive G6PD deficiency quantitative or pregnancy test.  Use o concomitant medicines; Any clinical or laboratory exam abnormality;
Smokers; heavy coffee drinkers (&gt;5 cups/Day); Abusive alcohol use: use of any treatment within 2 weeks before the study;Any previous hospitalization with 8 weeks before the study: Any previous treatment with known drug interaction with the test drug within 03 months; Blood donation greater than 450ml 03 months prior the study, or 1500ml in the previous 12 months; Use of Cyp 450 Inductors medications 4 weeks prior; Consume of alcohol or grapefruit 48h prior hospitalization;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-2xt4yk	"A Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP-196) 
in Subjects with Previously
Untreated Mantle Cell Lymphoma"	Recruiting	Intervention	2018-01-30	<NULL>	<NULL>	1605	"A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter
Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP-196) 
in Subjects with Previously
Untreated Mantle Cell Lymphoma"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital São Rafael/Monte Tabor-BA	INC Research	https://ensaiosclinicos.gov.br/rg/RBR-2xt4yk	<NULL>	"Men and women, &gt;65 years of age;
Pathologically confirmed MCL, with documentation of monoclonal CD20+ B cells that have a chromosome translocation t(11;14)(q13;q32) and/or overexpress cyclin D1;
MCL requiring treatment and for which no prior systemic anticancer therapies have been received;
Presence of radiologically measurable lymphadenopathy or extranodal lymphoid malignancy (as defined by Lugano Classification for NHL);
Eastern Cooperative Oncology Group (ECOG) performance status of &lt; 2
Men who are sexually active and can beget children must agree to use highly effective forms of contraception during the study and for 90 days after the last dose of acalabrutinib, 6 months after the last dose of bendamustine, or 12 months after the last dose of rituximab, whichever is longest;
Men must agree to refrain from sperm donation during the study and for 90 days after the last dose of acalabrutinib, 6 months after the last dose of endamustine, or 12 months after the last dose of rituximab, whichever is longest; Willing and able to participate in all required evaluations and procedures in this study protocol including swallowing capsules without difficulty;
Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information (in accordance with national and local patient privacy regulations)"	"History of prior malignancy except for the following:
Malignancy treated with curative intent and with no evidence of active disease present for more than 2 years before screening and felt to be at low risk for recurrence by treating physician;  
Note:  Provided they meet other eligibility criteria, subjects who are receiving hormonal therapy alone are allowed to enroll on study;
Adequately treated lentigo maligna melanoma without current evidence of disease or adequately controlled nonmelanomatous skin cancer;
Adequately treated carcinoma in situ without current evidence of disease;
Subjects for whom the goal of therapy is tumor debulking before stem cell transplant;
Any history of central nervous system (CNS) lymphoma or leptomeningeal disease;
Uncontrolled autoimmune hemolytic anemia (AIHA) or idiopathic thrombocytopenic purpura (ITP);
Major surgical procedure within 28 days before first dose of study drug.  Note: If a subject had major surgery, they must have recovered adequately from any toxicity and/or complications from the 
intervention before the first dose of study drug;
Significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of first dose of study drug, or any Class 3 
or 4 cardiac disease as defined by the New York Heart Association Functional Classification, or corrected QT interval (QTc) &gt; 480 msec (calculated using Friderica’s formula:  QT/RR0.33) at 
screening.  Exception: Subjects with controlled, asymptomatic atrial fibrillation during screening are allowed to enroll on study;
Absolute neutrophil count (ANC) &lt; 1.0 x 109/L or platelet count &lt; 75 x 109/L; for subjects with disease involvement in the bone marrow, ANC &lt; 0.75 x 109/L or platelet count &lt; 50 x 109/L.  Subjects will only be considered eligible if peripheral blood counts can be 
maintained independent of growth factors or transfusions during the screening period;
Total bilirubin &gt; 1.5 x upper limit of normal (ULN); or aspartate aminotransferase (AST) or 
alanine aminotransferase (ALT) &gt; 2.5 x ULN;
Estimated creatinine clearance of &lt; 50 mL/min, calculated using the formula of Cockcroft and Gault [(140-Age) • Mass (kg)/(72 • creatinine mg/dL) • multiply by 0.85 if female];
Prothrombin time/international normalized ratio (INR) or activated partial thromboplastin time (aPTT; in the absence of a Lupus anticoagulant) &gt; 2.0 x ULN; Exception:  Subjects receiving 
warfarin are excluded; however, those receiving other anticoagulant therapy who have a higher INR/aPTT may be permitted to enroll to this study after discussion
with the medical monitor;
Malabsorption syndrome, disease significantly affecting gastrointestinal function, resection of the stomach, extensive small bowel resection that is likely to affect absorption, 
symptomatic inflammatory bowel disease, partial or complete bowel obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass;
Uncontrolled active systemic fungal, bacterial, viral, or other infection (defined as exhibiting ongoing signs/symptoms related to the infection and without improvement, despite 
appropriate antibiotics or other treatment), or intravenous anti-infective treatment within 2 weeks before first dose of study drug;
Known history of infection with human immunodeficiency virus (HIV);
Ongoing immunosuppressive therapy, including systemic (eg, IV or oral) corticosteroids within 2 weeks before the first dose of study drug. Note: Subjects may use topical or inhaled corticosteroids or low-dose steroids as therapy for comorbid conditions. During
study participation, subjects may also receive systemic (eg, IV or oral) corticosteroids as needed for treatment-emergent comorbid conditions;
Known history of anaphylaxis or hypersensitivity to bendamustine, rituximab, or any of their 
components;
Serologic status reflecting active hepatitis B or C infection.
Subjects who are hepatitis B core antibody (anti-HBc) positive and who are surface antigen negative will need to have a negative polymerase chain reaction (PCR) result before randomization. 
Those who are hepatitis B surface antigen (HbsAg) positive or hepatitis B PCR positive will be excluded;
Subjects who are hepatitis C antibody positive will need to have a negative PCR result before randomization. Those who are hepatitis C PCR positive will be
excluded;
Received a live virus vaccination within 28 days of first dose of study drug;
History of stroke or intracranial hemorrhage within 6 months of first dose of study drug;
History of bleeding diathesis (eg, hemophilia or von Willebrand disease);
Presence of a gastrointestinal ulcer diagnosed by endoscopy within 3 months before first dose of study drug;
Requires or receiving anticoagulation with warfarin or equivalent vitamin K antagonists (eg, phenprocoumon) within 7 days of first dose of study drug;
Requires treatment with a strong cytochrome P450 3A (CYP3A) inhibitor/inducer;
Requires treatment with proton-pump inhibitors (eg, omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, or pantoprazole).  Subjects receiving proton-pump inhibitors who 
switch to H2-receptor antagonists or antacids are eligible for enrollment to this study;
Concurrent participation in another therapeutic clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-4m42nq	A study of eltrombopag in combination with azacitidine for subjects with low platelet counts due to intermediate 1, intermediate 2 or high risk Myelodysplastic Syndromes.	Recruiting	Intervention	2016-01-15	<NULL>	<NULL>	684	TRC112121 A phase III, randomized, double-blind, placebo-controlled, multi-center eltrombopague or placebo in combination with azacitidine in patients with Myelodysplastic Syndrome with IPSS intermediate-1 classification, intermediate-2 and high-risk.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2014-05-23	GlaxoSmithKline Brasil	GlaxoSmithKline	https://ensaiosclinicos.gov.br/rg/RBR-4m42nq	<NULL>	Myelodysplastic Syndromes risk ranked at Intermediate 1, intermediate 2 or high according to IPSS;At least one platelet count lower than 75 Gi/L;Eastern Cooperative Oncology Group(ECOG) Status 0-2.;  Adequate baseline organ function	Previous treatment with hypomethylating agent or induction chemotherapy for MDS;History of treatment with eltrombopag, romiplostim or other TPO-R agonists;Previous allogeneic stem-cell transplantation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-3dccf6	"A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Avoiding in Adult Participants With Treatment-resistant
Depression"	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	769	"A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant
Depression"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-07-09	Clinica Dr. Norton Sayeg Ltda. EPP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3dccf6	<NULL>	Inclusion Criteria: At the time of signing the informed consent form (ICF), participant must be a man or woman 18 (or older if the minimum legal age of consent in the country in which the study is taking place is greater than [&gt;]18) to 64 years of age, inclusive - At the start of the screening/prospective observational phase, participant must meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for single-episode major depressive disorder (MDD) (if single-episode MDD, the duration must be greater than or equal to [&gt;=] 2 years) or recurrent MDD, without psychotic features, based upon clinical assessment and confirmed by the Mini- International Neuropsychiatric Interview (MINI) - At the start of the screening/prospective observational phase, participant must have an Inventory of Depressive Symptomatology-Clinician rated ( IDS-C30) total score of greater than or equal to (&gt;=) 34 - At the start of the screening/prospective observational phase, participants must have had nonresponse to &gt;=2 but less than or equal to (&lt;=) 5 oral antidepressant treatments taken at adequate dosage and for adequate duration, as assessed using the Massachusetts General Hospital – Antidepressant Treatment Response Questionnaire (MGH-ATRQ) and documented by medical history and pharmacy/prescription records, for the current  episode of depression - The participant’s current major depressive episode and treatment response to antidepressant treatments used in the current depressive episode (retrospectively assessed) must be deemed valid for participation in a clinical study based on a Site-Independent Qualification Assessment For Transferred-Entry Participants - The participant must have completed the double-blind induction phase in ESKETINTRD3001 or ESKETINTRD3002 and must have demonstrated response at the end of that phase (&gt;=50% reduction in the MADRS total score from baseline [Day 1 pre-randomization] at the end of the 4-week double-blind induction phase)	Exclusion Criteria: - Participants who have previously demonstrated nonresponse of depressive symptoms to esketamine or ketamine in the current major depressive episode, to all 4 of the oral antidepressant treatment options available for the double-blind induction phase (ie, duloxetine, escitalopram, sertraline, and venlafaxine extended release [XR]) in the current major depressive episode (based on MGH-ATRQ), or an adequate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT – Participant currently has an implant for vagal nerve stimulation (VNS) or has received deep brain stimulation (DBS) in the current episode of depression - Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis, bipolar or related disorders (confirmed by the MINI), comorbid obsessive compulsive disorder, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder, or narcissistic personality disorder - Participant has homicidal ideation/intent, per the investigator’s clinical judgment, or has suicidal ideation with some intent to act within 6 months prior to the start of the screening/prospective observational phase, per the investigator’s clinical judgment or based on the Columbia Suicide Severity Rating Scale (CSSRS) - Participants with history of moderate or severe substance or alcohol use disorder according to DSM-5 criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-9pgk4f	A study of Intranasal Rapid Action Esketamine for Major Depression Treatment Resistant	Recruiting	Intervention	2016-04-01	<NULL>	<NULL>	778	A study of Intranasal Rapid Action Esketamine for Major Depressive Disorder Treatment Resistant	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-08-10	Centro De Psiquiatria E Pesquisas Sandra Ruschel Ltda	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9pgk4f	<NULL>	At the time of signing the informed consent form (ICF), participant must be a man or woman 18 (or older if the minimum legal age of consent in the country in which the study is taking place is greater than [&gt;]18) to 64 years of age, inclusive - At the start of the screening/prospective observational phase, participant must meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for single-episode major depressive disorder (MDD) (if single-episode MDD, the duration must be greater than or equal to [&gt;=] 2 years) or recurrent MDD, without psychotic features, based upon clinical assessment and confirmed by the Mini- International Neuropsychiatric Interview (MINI) - At the start of the screening/prospective observational phase, participant must have an Inventory of Depressive Symptomatology-Clinician rated ( IDS-C30) total score of greater than or equal to (&gt;=) 34 - At the start of the screening/prospective observational phase, participants must have had nonresponse to &gt;=2 but less than or equal to (&lt;=) 5 oral antidepressant treatments taken at adequate dosage and for adequate duration, as assessed using the Massachusetts General Hospital - Antidepressant Treatment Response Questionnaire (MGH-ATRQ) and documented by medical history and pharmacy/prescription records, for the current episode of depression: Subject must be taking an oral antidepressant treatment with nonresponse at the start of the screening/prospective observational phase - The participant’s current major depressive episode and treatment response to antidepressant treatments used in the current depressive episode (retrospectively assessed) must be deemed valid for participation in a clinical study based on a Site-Independent Qualification Assessment	Participants who have previously demonstrated nonresponse of depressive symptoms to esketamine or ketamine in the current major depressive episode, to all 4 of the oral antidepressant treatment options available for the double-blind induction phase (ie, duloxetine, escitalopram, sertraline, and venlafaxine extended release [XR]) in the current major depressive episode (based on MGH-ATRQ), or an adequate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT - Participant currently has an implant for vagal nerve stimulation (VNS) or has received deep brain stimulation (DBS) in the current episode of depression - Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis, bipolar or related disorders (confirmed by the MINI), comorbid obsessive compulsive disorder, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder, or narcissistic personality disorder - Participant has homicidal ideation/intent, per the investigator’s clinical judgment, or has suicidal ideation with some intent to act within 6 months prior to the start of the screening/prospective observational phase, per the investigator’s clinical judgment or based on the Columbia Suicide Severity Rating Scale (C-SSRS) – Participants with history of moderate or severe substance or alcohol use disorder according to DSM-5 criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-6txnfv	"A Study of JNJ-56021927 Plus Androgen
Deprivation Therapy (ADT) Versus ADT in
Participants with Low-Volume mHSPC"	Not yet recruiting	Intervention	2016-04-01	<NULL>	<NULL>	777	56021927PCR3002 - A Phase 3 Randomized, Placebocontrolled, Double-blind Study of JNJ-56021927 Plus Androgen Deprivation Therapy (ADT) Versus ADT in Subjects with Low-volume Metastatic Hormonesensitive Prostate Cancer (mHSPC)	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-11-20	Fundação Pio XII - Hospital de Câncer de Barretos	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-6txnfv	<NULL>	Adenocarcinoma of prostate; if diagnosed greater than or equal to (&gt;=) 5 years from randomization; Metastatic disease documented by &gt;= 2 bone lesions on 99mTc bone scan; Eastern Cooperative Oncology Group Performance Status (ECOG PS) grade of 0, 1, or 2; Allowed prior treatment for prostate cancer: a) Maximum of 1 course of radiation or surgical intervention; b) Up to 6 cycles of docetaxel for low-volume disease with the last dose within 2 months of randomization; c) Must not have experienced disease progression between the last dose of docetaxel and Screening; Participants who did not receive prior docetaxel may have received less than or equal to (&lt;=) 3 months of ADT in the metastatic disease setting prior to randomization. Participants who received prior docetaxel may have received &lt;= 6 months ADT in the metastatic setting prior to randomization; May also have received up to 6 months of GnRHa in the adjuvant or neo-adjuvant setting as long as it was completed greater than (&gt;)1 year prior to randomization; May have received radiation therapy or prostatectomy as definitive therapy	Pathological finding consistent with small cell, ductal or neuroendocrine carcinoma of the prostate - Known brain metastases - Lymph nodes as only site of metastasis – Visceral metastasis observed on computed tomography (CT)/magnetic resonance imaging (MRI) or &gt;= 4 bone lesions on 99mTc bone scan with at least 1 lesion beyond the pelvis or vertebral column - Any prior malignancy within 5 years prior to randomization with the exception of squamous or basal cell skin carcinoma or non-invasive superficial bladder cancer - Prior treatment with other second generation anti-androgens or other CYP17 inhibitors, immunotherapy or radiopharmaceutical agents for prostate cancer - History of seizures or  medications known to lower seizure threshold	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-2myky3	A study of the efficacy of knee alcohol block for the treatment of knee arthrosis pain	Recruiting	Intervention	2020-02-17	<NULL>	<NULL>	3498	A prospective study of the efficacy of anterior and posterior knee alcohol neurolysis for the treatment of knee osteoarthrosis pain	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2myky3	<NULL>	Aged over 18 years. With knee pain for more than six months without improvement with clinical treatment and clinical and imaging diagnosis (radiography) of knee osteoarthritis with moderate pain intensity (pain greater than 4 by numerical scale).	Patients with cognitive impairment or psychiatric illness or other causes of knee pain (trauma; complex regional pain syndrome; prosthesis); infection at the puncture site; coagulopathy; anticoagulant use will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-10gd8362	A study of the IndigoTM aspiration system seeking to evaluate the long-term safety of treating Pulmonary Embolism	Recruiting	Observational	2024-08-29	<NULL>	<NULL>	7298	A prospective, multicenter study of the IndigoTM aspiration system seeking to evaluate the long-term safety and outcomes of treating Pulmonary Embolism	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-25	Centro Universitário do Distrito Federal	Hospital Santa Lucia Sul	https://ensaiosclinicos.gov.br/rg/RBR-10gd8362	<NULL>	Clinical signs and symptoms consistent with acute Pulmonary Embolism with duration of 14 days or less. Right Ventricle and Left Ventricle ratio greater than or equal 0.9 assessed by diagnostic computed tomographic angiography (CTA) or echocardiogram. Frontline endovascular treatment with the Indigo Aspiration System per Instructions For Use. Patient, man or woman, is greater than or equal 18 years of age. Informed consent obtained per Institutional Review Board/Ethics Committee requirements	Contraindication to systemic or therapeutic doses of anticoagulants (e.g. heparin). Stage III or IV cancer or cancer which requires active chemotherapy during the course of the study. Known serious, uncontrolled sensitivity to radiographic agents. Life expectancy less than 180 days. Patients on extracorporeal membrane oxygenation. Pregnant patients. Current participation in another investigational drug or device study that may confound the results of this study. Studies requiring extended follow-up for products that were investigational but have since become commercially available are not considered investigational studies. Other medical, social, or psychological conditions that, in the opinion of the Investigator, precludes the patient from appropriate consent, could limit the patient&apos;s ability to participate in the study, including compliance with follow-up requirements, or that could impact the scientific integrity of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-27qyp2	A study of three formulations of primaquine in healthy volunteers	Recruitment completed	Intervention	2020-05-27	<NULL>	<NULL>	3880	A comparative bioavailability study of three formulations of primaquine in healthy volunteers	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2019-05-15	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-27qyp2	<NULL>	"Men,
Non-pregnant and non-breastfeeding women
Within the age range 18 to 50 years old
Body Mass index range 19 to 28,5 Kg/m2
Health volunteers
Signed Informed Consent"	"Hypersensibility to the drug (primaquine): Previous pathologies that could influence the absorption distribution or excretion of the drug; Positive G6PD deficiency quantitative or pregnancy test.  Use o concomitant medicines; Any clinical or laboratory exam abnormality;
Smokers; heavy coffee drinkers (&gt;5 cups/Day); Abusive alcohol use: use of any treatment within 2 weeks before the study;Any previous hospitalization with 8 weeks before the study: Any previous treatment with known drug interaction with the test drug within 03 months; Blood donation greater than 450ml 03 months prior the study, or 1500ml in the previous 12 months; Use of Cyp 450 Inductors medications 4 weeks prior; Consume of alcohol or grapefruit 48h prior hospitalization;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-8nb7xf	A study that evaluates the influence of an exercise program guided and structured combined with sleep hygiene measures on the metabolic changes, sleep disturbances and quality of life in patients with type 2 diabetes.	recruiting	Observational	2012-02-01	<NULL>	<NULL>	79	A Randomized study on the effects of sleep hygiene in glycemic control in patients with type 2 diabetes mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	UFC- Universidade Federal do Ceará	UFC- Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8nb7xf	<NULL>	"Know diagnosed type 2 diabetes for at least 6 months.
Men and Woman.
Aged between 40 and 60 years.
Sign the consent term."	"Shift workers
Drug abuse
Hospitalization (past 30 days)
Severe comorbities (renal or hepatic impairment, advanced neoplasia, severe heart failure, severe neurological disorder)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-3q8j43	A study to evaluate both the efficacy and safety profile of CP 690,550 in patients with moderately to severely active ulcerative colitis	Recruiting	Intervention	2015-02-17	<NULL>	<NULL>	391	A multicentre, randomized, double-blind, placebo controlled, parallel group study of oral CP 690,550 as an induction therapy in subjects with moderate to severe ulcerative colitis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-10-21	Hospital de Clínicas de Porto Alegre (Centro Coordenador)	Laboratórios Pfizer Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3q8j43	<NULL>	"Subject must be at least 18 years of age; males and females with a documented diagnosis of ulcerative colitis (UC) at least 4 months prior to entry into the study; subjects with moderately to severely active UC based on Mayo score criteria; subjects must have failed or be intolerant of at least one of the following treatments for UC: corticosteroids (oral ou intravenous), azathioprine or 6 mercaptopurine (6MP), anti TNF alpha therapy (infliximab ou
adalimumab)."	"Presence of indeterminate colitis, microscopic colitis, ischemic colitis, infectious colitis, or clinical findings
suggestive of Crohn&apos;s disease; subjects with disease limited to distal 15 cm; subjects without previous treatment for UC (ie, treatment naive); subjects displaying clinical signs of fulminant colitis or toxic megacolon."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-4dk4rss	A study to evaluate innate and pro-inflammatory responses of an Ad26-based SARS-CoV-2 vaccine, an Ad26-based RSV vaccine, and an Ad26-based Ebola virus vaccine in adults aged 18 to 59 years	Not yet recruiting	Intervention	2022-09-21	<NULL>	<NULL>	5620	VAC18193RSV2008 A Randomized, observer-blind, phase 1 study to evaluate innate and pro-inflammatory responses of an Ad26.RSV.preF-based vaccine, Ad26.COV2.S vaccine and Ad26.ZEBOV vaccine in adults aged 18 to 59 years	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2022-11-03	Janssen Vaccines &amp; Prevention B.V	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4dk4rss	<NULL>	Participant must have a body mass index less than 35.0 kilograms per meter square. In the investigator’s clinical judgment, participant may have a stable and well-controlled medical condition including comorbidities associated with an increased risk of progression to severe coronavirus disease-2019, as long as their symptoms and signs are stable at the time of vaccination, and these conditions receive routine follow-up by the participant’s healthcare provider. Participants will be included on the basis of relevant medical history, vital signs, and body mass index measurement at screening. - Participant agrees to not donate bone marrow, blood, and blood products from the first study vaccine administration until 3 months after receiving the last dose of study vaccine. Before randomization, participants must be either: (a) Not of childbearing potential; (b) Of childbearing potential and practicing an acceptable effective method of contraception and agrees to remain on such a method of contraception from signing the consent until 3 months after the last dose of study vaccine (including optional Ad26.COV2.S vaccination on Day 29 in Groups 2 and 3). Use of hormonal contraception should start at least 28 days before the first administration of study vaccine	Participant has a history of malignancy within 5 years before screening (exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situ of the cervix, or malignancy, which is considered cured with minimal risk of recurrence). Participant has a known or suspected allergy or history of anaphylaxis or other serious adverse reactions to vaccines or their excipients (including any of the excipients of the study vaccine, or trace residues [chicken and/or egg proteins, gentamicin]). Per medical history, participant has chronic active hepatitis B or hepatitis C infection. Per medical history, participant has human immunodeficiency virus type 1 or type 2 infection. Participant has a history of acute polyneuropathy (example, Guillain-Barré Syndrome) or chronic inflammatory demyelinating polyneuropathy. Participant has abnormal function of the immune system resulting from: (a) Clinical conditions (example, autoimmune disease or immunodeficiency) expected to have an impact on the immune response elicited by the study vaccine. Participants with autoimmune disease (example, autoimmune-mediated thyroid disease, autoimmune inflammatory rheumatic disease such as rheumatoid arthritis, and Type 1 diabetes) that is stable and inactive without the use of systemic immunomodulators, and glucocorticoids may be enrolled at the discretion of the investigator; (b) Use of systemic corticosteroids within 2 months before administration of the first study vaccine until 28 days after first study vaccination. A substantial immunosuppressive steroid dose is considered to be greater than (&gt;) 2 weeks of daily receipt of 20 milligrams (mg) prednisone or equivalent. Note: Ocular, topical, or inhaled steroids are allowed; (c) Administration of antineoplastic and immunomodulating agents, example, cancer chemotherapeutic agents, or radiotherapy within 6 months before administration of study vaccine until 28 days after first study vaccination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3q2sdt	A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(alpha) Refractory Participants With Active Radiographic Axial Spondyloarthritis	Recruiting	Intervention	2016-03-29	<NULL>	<NULL>	766	CNTO1275AKS3002 - A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(alpha) Refractory Subjects With Active Radiographic Axial Spondyloarthritis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-09-18	LMK Serviços Médicos SS	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3q2sdt	<NULL>	Inclusion Criteria: Participants must have a diagnosis of definite ankylosing spondylitis (AS), as defined by the modified 1984 New York criteria. The radiographic criterion must be confirmed by a central xray reader and at least 1 clinical criterion must be met; Participants must have symptoms of active disease at screening and at baseline, as evidenced by both a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score of greater than or equal to (&gt;=4) and a visual analog scale (VAS) score for total back pain of &gt;=4, each on a scale of 0 to 10; Participants with elevated high sensitivity C-reactive protein (hsCRP) level of &gt;=0.300 milligram per deciliter (mg/dL) at screening - Refractory by either lack of benefit or documented intolerance to 1 and no more than 1 anti-TNF(alpha) agent; Inadequate response to at least 2 nonsteroidal anti-inflammatory drugs (NSAIDs) over a 4-week period in total with maximal doses of NSAID(s), or is unable to receive a full 4 weeks of maximal NSAID therapy because of intolerance, toxicity, or contraindications to NSAIDs.; Participants with complete ankylosis of the spine are permitted to be included in the study, but will be limited to approximately 10 percent (%) of the study population	Exclusion Criteria: Participants who have other inflammatory diseases that might confound the evaluations of benefit from the ustekinumab therapy, including but not limited to, rheumatoid arthritis, systemic lupus erythematosus, or Lyme disease - Participants who have received infliximab or infliximab biosimilar, within 12 weeks of the first study agent administration; have received adalimumab, adalimumab biosimilar, or certolizumab pegol within 6 weeks of the first study agent administration; have received etanercept or etanercept biosimilar within 6 weeks of the first study agent administration;  Participants who have ever received golimumab ; Participants who are pregnant, nursing, or planning a pregnancy or fathering a child while enrolled in the study or within 5 months after receiving the last administration of study agent; Participants who have received any systemic immunosuppressives or disease-modifying antirheumatic drugs (DMARDs) other than methotrexate (MTX), sulfasalazine (SSZ), or hydroxychloroquine (HCQ) within 4 weeks prior to first administration of study agent. Medications in these categories include, but are not limited to leflunomide, chloroquine, azathioprine, cyclosporine, mycophenolate mofetil, gold, and penicillamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-3xk32h	A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants with Treatment-resistant Depression	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	771	A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy,  Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly  Subjects with Treatment-resistant Depression	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-08-24	Clinica Dr. Norton Sayeg Ltda. EPP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3xk32h	<NULL>	Study population will include older men and women, 65 years of age (inclusive) and above, meeting the Manual of diagnostic criteria Diagnostic and Statistical of Mental Disorders (5th edition, DSM-5) for single episode of MDD (if MDD single episode, the duration shall be 2 years) or MDD recurrent without psychotic features, based on clinical assessment and confirmed by the International Mini Neuropsychiatric Interview (MINI). In addition, the research participant must have a total score of Inventory Symptomatology Depressiva Evaluated by Medical 30 items (IDS-C30) of 34, which corresponds to moderate depression severa.No early screening / prospective observational phase, research participants should be submitted no response to 2, but 5, oral antidepressant treatments administered at an appropriate dose and a suitable duration, as assessed using the response Questionnaire Treatment antidepressant - Massachusetts General Hospital (MGH-ATRQ) and documented by medical history and pharmacy records / prescription for the current episode of depression. At the start of screening / prospective observational phase, the research participant must be one of those currently taking antidepressant treatments with non-major depressive episode documentada.O response current research participant and the treatment response to antidepressant treatments used in the present depressive episode ( assessed retrospectively) should be considered valid for participation in a clinical trial based on a Qualification Assessment Centre Independent. The Qualification Assessment Centre Independent is a tool to facilitate the selection of research participants for clinical studies of MDD, with a goal to ensure the inclusion of research participants that reflect the current state of disease, and that these symptoms can be measured reliably with appropriate measuring tools	Potential research participants will be excluded from participation in the study if they have previously shown no response of depressive symptoms to escetamina or ketamine in the current major depressive episode, all four options oral antidepressant treatment available for the phase double-blind induction (ie, duloxetine, escitalopram, sertraline and venlafaxine XR) a larger current depressive episode (based on MGHATRQ), or an appropriate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT. Research participants who currently have an implant to vagal nerve stimulation (VNS) or who received deep brain stimulation (DBS) in this major depressive episode will be deleted. Survey participants will also be excluded if they have a DSM-5 diagnostic current or previous a psychotic or MDD disorder with psychosis, bipolar and related disorders (confirmed by MINI), obsessive compulsive disorder comorbid, neurodegenerative disorder (eg., Disease Alzheimer&apos;s disease, vascular dementia, Parkinson&apos;s disease) or mild cognitive impairment evidence (MCI), a score of the Mini-Mental State Examination (MMSE) &lt;25, STOP-Bang questionnaire score of 5, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder or narcissistic personality disorder; if they presented ideation / intent homicidal or suicidal ideation with any intention to act within 6 months before the start of the phase of screening / prospective observational according to the clinical judgment of the investigator and / or based on Suicide Severity Rating Scale Columbia (C-SSRS); or have a history of disorder or substance use moderate or severe alcohol according to the DSM-5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-2vw8282	A study to evaluate the use of eSight magnifying glasses in adults with Low Vision	Not yet recruiting	Observational	2021-10-14	<NULL>	<NULL>	4985	A study to evaluate the use of eSight magnifying glasses in adults with Low Vision	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-01	IPEPO - Instituto Paulista de Estudos e PEsquisas em Oftalmologia	IPEPO - Instituto Paulista de Estudos e PEsquisas em Oftalmologia	https://ensaiosclinicos.gov.br/rg/RBR-2vw8282	<NULL>	lucid, mentally competent and with stable vision in the last 6 months who can attend the examination site. Best corrected visual acuity in the best eye ranging from 20/60 to 20/400 and / or visual field&gt; 20º (monocular or binocular) with one of the following comorbidities: Stargardt&apos;s disease, Eye coloboma, Nystagmus, Aniridia, Retinopathy of Prematurity, Macular degeneration Age-related, Retinal Detachment, Diabetic Retinopathy, Uveitis and other infectious diseases, Cone dystrophy, Leber&apos;s Congenital Amaurosis, Pigmentary Retinosis, Optic Nerve Hypopasia, Glaucoma, Optic Nerve Atrophy, Neuropathy. The patient must accept to use eSight in varied situations that simulate everyday situations and in public environments, open and or closed or at the discretion of the investigator.	Visual acuity better corrected in the best eye better than 20/60. Inability to attend the examination site to perform it. Inability to understand the use of the equipment and to provide data to assess its use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-2z5rgg	A study to validate A Glucose-6-Phosphate Dehydrogenase enzyme assay	Data analysis completed	Intervention	2016-05-22	<NULL>	<NULL>	857	A follow-up of validation test protocol enzyme glucose 6-phosphate dehydrogenase ( G6PD ) to study TAF112582	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-24	Fundação de Medicina Tropical do Amazonas	Medicines for Malaria Venture	https://ensaiosclinicos.gov.br/rg/RBR-2z5rgg	<NULL>	"The subject is between 18 and 45 years of age,  male; 
Hgb concentration greater or equal than 12g/dL; 
Reticulocyte count less or equal than 2.5%; 
A signed and dated informed consent from the subject or the subject’s legal representative prior to screening"	"History of haemoglobinopathy; 
Past or current history of methaemoglobinaemia or methaemoglobin percentage above 3%; 
Past medical history of G6PD deficiency; Any other co-morbidity or treatment that, in the opinion of the investigator might
influence haematopoiesis; 
Any person that may have donated blood in the last 56 days"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-3rx9fj	A Study with additional chart review to evaluate clinical and biochemical characteristics and disease progression in patients with mucopolysaccharidosis type IIIB	Recruitment completed	Observational	2015-07-06	<NULL>	<NULL>	666	A prospective cross-sectional and longitudinal study with additional restrospective chart review to evaluate clinical and biochemical characteristics and disease progression in patients with mucopolysaccharidosis type IIIB	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-07-15	Hospital de Clínicas de Porto Alegre	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3rx9fj	<NULL>	Definitive diagnosis of MPS IIIB; at least 1 years of age (biological age) at the time of written informed consent; understands the full nature and purpose of the study, including possible risks of study procedures; informed consent signature.	Visual or hearing impairments sufficient to preclude cooperation with neurodevelopmental testing; history of poorly-controlled seizure disorder; currently receiving medication which, in the Investigator’s opinion, would be likely to substantially confound interpretation of the results, or has been on the current dose of psychotropic medication for less than 3 months; receiving a newly increased dose of melatonin (e.g., less than 3 months on current dose); previously received an investigational therapy for the treatment of MPS IIIB or has had hematopoietic stem cell transplant (HSCT); in the opinion of the Investigator, the patient has any other prior or ongoing medical condition that may present a safety risk, interfere with study compliance, or confound data interpretation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-8z787r	A Study without Drug Intervention to Observe Bleeding Episodes, Factor VIII Infusions, and Patient-Reported Outcomes in Individuals with Severe Hemophilia A	Recruitment completed	Observational	2018-11-06	<NULL>	<NULL>	3393	A Prospective Non-Interventional Study of Bleeding Episodes, Factor VIII Infusions, and Patient-Reported Outcomes in Individuals with Severe Hemophilia A	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-01-11	BioMarin Pharmaceutical Inc.	UNICAMP - Campus Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8z787r	<NULL>	"Males major of 18 years of age with hemophilia A and residual FVIII levels minor or equal 1 IU/dL, as evidenced by medical history, at the time of signing the informed consent.
Must have been on prophylactic FVIII replacement therapy for at least 6 months prior to study entry. High-quality, well-documented historical data concerning bleeding episodes and FVIII usage over the previous 6 months must be available.
Treated/exposed to FVIII concentrates or cryoprecipitate for a minimum of 150 exposure days (EDs).
Willing and able to provide written, signed informed consent after the nature of the study has been explained and prior to any study-related procedures.
No history of FVIII inhibitor, and results from a Bethesda assay with Nijmegen modification of less than 0.6 Bethesda Units (BU) on 2 consecutive occasions (the most recent one of which should be tested at the central laboratory) at least one week apart previously.
Known status of antibodies against the AAV5 capsid. Participants may be either AAV5- or AAV5+.
HIV-positive patients may be enrolled, only if the patient has a CD4 count &gt; 200/mm3 and an undetectable viral load.
Have the ability to comply with protocol requirements in the opinion of the Investigator."	"Significant liver dysfunction with any of the following abnormal laboratory results:
ALT (alanine transaminase) or AST &gt;2X upper limit of normal (ULN);
Total bilirubin &gt;2X ULN;
Alkaline phosphatase &gt;2X ULN; or
INR (international normalized ratio) major or equal 1,4
Patients whose liver laboratory assessments fall outside of these ranges may undergo repeat testing and, if eligibility criteria are met on retest, may be enrolled after confirmation by the Medical Monitor. In addition, patients with abnormal laboratory results related to confirmed benign liver conditions (eg, Gilbert’s syndrome) are considered eligible for the study notwithstanding their abnormal laboratory results and may be enrolled after discussion with the Medical Monitor.
Prior liver biopsy showing significant fibrosis of 3 or 4 as rated on a scale of 0-4 on the Batts-Ludwig (Batts 1995) or METAVIR (Bedossa 1996) scoring systems, or an equivalent
grade of fibrosis if an alternative scale is used.
Liver cirrhosis of any etiology as assessed by prior liver ultrasound.
Chronic or active hepatitis B as evidenced by positive serology testing and confirmatory HBV DNA testing. Refer to the Centers for Disease Control (CDC) table for the interpretation of serological test results in the Laboratory Manual.
Active hepatitis C, as evidenced by detectable HCV RNA or currently on antiviral therapy.
Active malignancy, except non-melanoma skin cancer.
History of hepatic malignancy.
Evidence of any bleeding disorder not related to hemophilia A.
Has a medical condition or extenuating circumstance that, in the opinion of the Investigator, might compromise the participant’s ability to comply with protocol requirements, the
participant’s wellbeing or safety, or the interpretability of the participant’s clinical data.
Prior treatment with any vector or gene transfer agent.
Concurrent enrollment in another clinical study, unless it is an observational (noninterventional) clinical study that does not interfere with the requirements of the current protocol and with prior consultation with the Medical Monitor.
Unwilling to receive blood or blood products for treatment of an AE and/or a bleeding episode."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-2v3sqdx	A test with patients aimed at proving the efficacy of Hycos Dérmico, assisting in the application of wound dressings without damaging the skin affected by the disease.	Recruiting	Intervention	2024-10-31	<NULL>	<NULL>	7471	Single-blind clinical study on the efficacy and safety of the product Hycos Dérmico	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Instituto de Saúde e Bem estar da Mulher	Nipo Serviços Médicos SS Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2v3sqdx	<NULL>	The participating patient has a wound, lesion, or bedsore. The injury requires dressings. Age between 18 and 90 years old. Any ethnicity, color/race, and skin phototype. Both genders. Patients are in the early stages of treatment	Pregnancy. Neonates. Sensitivity to the components of the medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-6fntmd	AAssessment of the potential for improvement in hearing health. Consumer satisfaction with sound amplification with a new high-performance hearing aid-WHO-Inc compared to existing Digital.	Recruitment completed	Intervention	2019-04-30	<NULL>	<NULL>	2643	Assessment of the potential of hearing improvement by performing a double-blind, randomized, cross-over study in the state of São Paulo. Consumer satisfaction with sound amplification in everyday life with a new high-performance hearing aid - WHO Inc. compared to advanced digital hearing aids available on the market	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6fntmd	<NULL>	"Sensorineural hearing loss with tonal thresholds of 25-85 dB NA per octave frequency between 250 and 4000 Hz, in 4 frequencies up to the threshold of 30-70 dB NA;
Not Protected with AASI in the last year;
Being in good health (self report);
Present normal vision or corrected vision for normal vision (less than or equal to 20 / 50)
Age between 21 and 75 years;
Maintain ability to speak, read and write;
No evidence of significant accumulation of wax or a foreign body in your external ear canal;"	"Presence of acute or chronic limiting diseases;
Presence of unilateral or worsening hearing loss in the last 90 days;
Blockage of the external ear canal or Ear infection or clogged ear sensation;
Otorrhea in the last 90 days;
Presence of sudden hearing loss in the last 90 days;
Dizziness or vertigo at the time of selection;
Presence of any congenital or traumatic deformity of the ear;
Presence of pain or discomfort in the ear;
Presence of conductive hearing loss or asymmetric hearing loss;
Presence of hearing loss that exceeds the limits that can be successfully aided by hearing loss (hearing loss);
Presence of air bone GAP greater than or equal to 15 decibels at 500 Hz, 1,000 Hz and 2000 Hz.
History of otological diseases or neurological disorders;
Individuals who do not speak Portuguese;
Any clinically unstable medical condition;
Any condition which, in the investigator&apos;s opinion, places the participant at unacceptable risk if participating in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-6pksdp	Abdominoplasty after surgery to reduce stomach and weight loss, may develop a fluid in the abdominal wall (seroma) when leaving a layer of the abdominal wall called fascia.	Recruitment completed	Intervention	2017-06-20	<NULL>	<NULL>	1262	Fascia of Scarpa in the formation of seroma in abdominoplasty after bariatric surgery.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal de Sao Paulo	Universidade Federal de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pksdp	<NULL>	"Patients undergoing gastroplasty who need anchor abdominoplasty 
 Age between 25 and 55 years,
Feminine gender,
BMI less than 30 kg per m²,
Not being nulliparous and at most three pregnancies,
Without restriction as to ethnicity, schooling or social class,
No smoking for at least 2 months"	neoplasia, diabetes mellitus, systemic arterial hypertension diseases of the lymphatic system, and carriers of preexisting abdominal surgery scars, other than those resulting from bariatric surgery, and the Pfannenstiel scar.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-9vdnz3	Ability of a Test that simulates spontaneous breathing predict successful extubation of Premature Infants: comparison between two protocols	Recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2288	Spontaneous Breathing Test as a predictor of successful extubation in Extremely Preterms Infants: comparison between two protocols	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Centro Universitário CESMAC	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9vdnz3	<NULL>	Preterm infants; both sexes; birth weight less than 1500g; Early Respiratory Distress Syndrome diagnostic; on invasive mechanical ventilation for more than 24 hours.	Presence of cardiac malformation, neurological dysfunction or genetic syndrome; occurrence of non-scheduled extubation or death before extubation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-6bj2czr	Ability of Laser Treatment on acupuncture spots on the control of Dry Mouth in patients with Sjögren Syndrome: randomized clinical trial	Recruiting	Intervention	2023-12-21	<NULL>	<NULL>	6673	Eficacy of Photobiomodulation Therapy on acupuncture spots on the control of Xerostomia in patients with Sjögren Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6bj2czr	<NULL>	Volunteers with minimum age of 18 years-old and no maximum age limit; diagnosed with Sjögren&apos;s Syndromes according to the American College of Rheumatology and the European League Against Rheumatism	Patients with xerostomia that can not be related to Sjögren&apos;s Syndromes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-43rsyw8	Ability to spontaneous breathing test to identify successful withdrawal of the tube and mechanical ventilator in preterm infants	Recruitment completed	Intervention	2021-05-12	<NULL>	<NULL>	4641	Evaluation of the Spontaneous Breathing Test (TRE) as a predictor of successful extubation of mechanical ventilation in preterm newborns	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Hospital Sofia Feldman/ Fundação de Assistencial Integral à Saúde	Hospital Sofia Feldman/ Fundação de Assistencial Integral à Saúde	https://ensaiosclinicos.gov.br/rg/RBR-43rsyw8	<NULL>	NB of gestational age minor than 37 weeks; Signature of the free and informed consent term (EHIC) by the mother or responsible for the NB; Conduct present respiratory; First extubation; Respiratory frame stable for at least 6 hours; Supporting ventilatory parameters: Respiratory rate (RR) 15 to 28 hours / Inspiratory peak pressure minor or equal than 16 cmH2O / Positive expiratory pressure minor or equal than 5 cmH2O / FiO2 minor or equal than0.35 / PH 7,25-7,45 (PaO2) 50-80 mmHg / Carbon dioxide arterial pressure (PaCO2) minor than 40 mmHg / Mean airway pressure minor or equal than 8 cmH2O	Presence of severe heart disease, malformation, genetic syndrome and neuromuscular disease; Presence of audible air leakage around the endotracheal tube; Continuous sedation; Hemodynamically unstable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-9ns5db	Abiraterone acetate in Patients With Metastatic Castration-Resistant Prostate Cancer	Recruitment completed	Intervention	2016-04-11	<NULL>	<NULL>	796	Abiraterone acetate in Patients With Metastatic Castration-Resistant Prostate Cancer, Chemo-naive, Who Received a Prior Diethylstiboestrol Therapy- 212082PCR2036	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2014-10-21	Faculdade de Medicina do ABC	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9ns5db	<NULL>	Histologically or cytologically confirmed adenocarcinoma of the prostate without neuroendocrine differentiation or small cell histology; Prior therapy with diethylstilbestrol (DES) for castration resistant prostate cancer; Participants should demonstrate evidence of progression on DES or evidence of grades 3/4 toxicities on DES; Metastatic disease documented by positive bone scan or metastatic lesions on computerized tomography (CT) or magnetic resonance imaging (MRI); May have received prior androgen blockage (bicalutamide or flutamide) but must have been discontinued for least 28 days;  Ongoing androgen deprivation therapy (ADT) (luteinizing hormone-releasing hormone [LHRH] agonist or orchiectomy), with serum testosterone level of less than 50 nanogram per deciliter (1.7 nanomole per liter); Eligible participants must maintain ADT	Active infection or other medical condition that would make prednisone use contraindicated; Any chronic medical condition requiring a higher systemic dose of corticosteroid than 5 milligram (mg) prednisone per day; Pathological finding consistent with small cell carcinoma of the prostate; Known brain metastasis; Has had prior cytotoxic chemotherapy or biologic therapy for the treatment of metastatic castration-resistant prostate cancer (mCRPC)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-5zsczhf	Abiraterone at a low dose compared to the normal dose for patients with metastatic Prostate Cancer who have previously used Docetaxel	Recruitment completed	Intervention	2026-05-08	<NULL>	<NULL>	9185	Low-dose Abiraterone versus standard dose in Metastatic castration-resistant Prostate Cancer after Docetaxel: a randomized controlled trial in Brazil DUMONT	<NULL>	3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-01	Liga Norte Rio Grandense Contra o Câncer	<NULL>	<NULL>	<NULL>	Male patients over 18 years old; with metastatic castration-resistant prostate cancer; previously treated with Androgen Deprivation Therapy (ADT) and chemotherapy (CT) with docetaxel; chemically or surgically castrated; patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of menor ou igual a 1; patients must be able to take the medication orally as directed and be able to fast for at least 8 hours before and at least 2 hours after taking the medication in the full dose arm; for the low-dose arm (LOW), the patient must be able to take the medication concurrently with or within 30 minutes after a conventional low-fat breakfast	Those who have already used abiraterone; who have not previously undergone treatment with Androgen Deprivation Therapy (ADT) and/or docetaxel; who are not chemically or surgically castrated; who have an Eastern Cooperative Oncology Group (ECOG) performance status greater than or equal to 2; who are unable to take the medication as directed according to the study arm	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-4n2c59	Absorption of Amoxicillin tablets in overweight volunteers	Recruitment completed	Intervention	2019-10-14	<NULL>	<NULL>	3080	Determination of pharmacokinetic profile of Amoxicillin tablets in overweight volunteers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-16	Hospital Universitário Regional de Maringá	Hospital Universitário Regional de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-4n2c59	<NULL>	Volunteers with obesity according to the classification proposed by the World Health Organization (BMI 30 to 40 kg / m²); being between 18 and 50 years old; have signed the consent form.	Intolerance or hypersensitivity to Amoxicillin and other antibiotics of the class; kidney or liver failure; pregnancy; breast-feeding; users of alcohol or illicit drugs; use of prokinetics (metoclopramide, erythromycin or domperidone); participation in clinical study in the last 3 months; have thrombocytopenia, anemia, heart disease, diabetes and / or hypertension, and endocrine disorders; being under 18 years old and over 50 years old; volunteers with difficulty in swallowing and / or presenting fistulas, significant stenosis or obstruction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-4mzhbd3	Accelerated protocol of Non-Invasibe Neuromodulation for Pain control	Recruiting	Intervention	2024-09-19	<NULL>	<NULL>	7359	Accelerated protocol of Repetitive Transcranial Magnetic Stimulation for Chronic Musculoskeletal Pain control	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-01-01	Instituto Multidisciplinar de Reabilitação e Saúde - Universidade Federal da Bahia	Hospital Universitário Pedro Ernesto / UERJ	https://ensaiosclinicos.gov.br/rg/RBR-4mzhbd3	<NULL>	Adult individuals aged 18 or over; both genders; with musculoskeletal-origin Chronic Pain, diagnosed by a specialist physician for at least three months, and with a pain intensity greater than 4/10 on the Visual Analog Pain Scale (VAS)	Participants with diagnosis of fibromyalgia and migraine; more than 20% of electroencephalogram (EEG) channels requiring rejection due to artifacts; change in their pharmacological or non-pharmacological treatment regimen during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-7gqgjm	Acceptability and continued use of the  contraceptive implant (Implanon) compared to others contraceptive methods in the Brazilian public sector	Terminated	Observational	2019-04-24	<NULL>	<NULL>	6482	Acceptability and continued use of the etonogestrel-releasing contraceptive implant (Implanon) compared to the levonorgestrel-releasing intrauterine system (IU-LNG), the intrauterine device (IUD) TCu380A and short-term methods in the Brazilian public sector	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-07-04	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-7gqgjm	<NULL>	Women between the ages of 18 and 40; Literacy; New Implanon acceptors; TCu380A IUDs; SIU-LNG and short-term methods like combined pill, injectable and vaginal ring	history of tromboembolism;  uterine malformations; blood hipertension; diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-6jsp9fs	Acceptability, feasibility, and efficacy of an online individual intervention on Mindfulness and Trial-based Cognitive Therapy for the well-being of the judiciary	Recruiting	Intervention	2024-04-15	<NULL>	<NULL>	6934	Acceptability, feasibility, and efficacy of an online individual intervention based on Mindfulness and Trial-based Cognitive Therapy for the psychological well-being of judges and public servants in the judiciary	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-30	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6jsp9fs	<NULL>	adults of both sexes; employees; or judges of TRT5; aged 18 years or older; with a score of 7 or more on the SRQ-20. Participants should be able to read, write, and follow instructions and must have internet access	self-declaration of severe symptoms of any mental disorder or ongoing organic disease; having a personality disorder; a diagnosis of schizophrenia; psychotic disorder; suicidal ideation; or drug use causing cognitive impairments in attention and concentration; being in the early stages or adjusting to pharmacological and/or psychotherapeutic treatment; and being a regular practitioner of mindfulness, meditation, or similar practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-8pd94mw	Acceptance and Commitment Therapy associated with Exposure in OCD: Online Group Experiment	Recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6291	Acceptance and Commitment Therapy associated with Exposure and Prevention Response in Obsessive-Compulsive disorder: An open online group trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro -IPUB	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro -IPUB	https://ensaiosclinicos.gov.br/rg/RBR-8pd94mw	<NULL>	Current diagnosis of Obsessive-Compulsive Disorder (OCD); The OCD must be the most severe disorder; Be in regular treatment with a psychiatrist at the clinic and on stabilized medication for at least one month and willing to remain on a fixed dose during study participation (unless advised by a physician of necessary change); 18 years old; Ability to read and complete questionnaires; Minimum score of 4 on the Clinical Global Impression (CGI).	Presence of psychotic disorders, bipolar disorder, mental retardation, recent history of alcohol or other substance abuse or dependence, severe personality disorder (as assessed by the attending physician); Severe organic medical disorder; Significant current or recent suicide risk; Any concomitant psychotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-5qynxgg	Access bar therapy as a treatment proposal for subjects with chronic Tinnitus	Recruitment completed	Intervention	2023-01-19	<NULL>	<NULL>	5832	Chronic tinnitus: Analysis of therapy with Access Bar as a treatment proposal	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-10	Universidade Federal de Santa Maria -UFSM	Universidade Federal de Santa Maria -UFSM	https://ensaiosclinicos.gov.br/rg/RBR-5qynxgg	<NULL>	Subjects with normal hearing thresholds or sensorineural hearing loss to a moderate degree; subjects with hearing loss in isolated frequencies; both genders; tinnitus with unilateral or bilateral perception of at least six months; tinnitus of different causes; age between 18 and 60 years old; Analogic visual scale minimum score of five.	Subjects with neurological or psychiatric problems reported in the anamnesis and researched in individual medical records; external or middle ear alterations; subjects who are undergoing any treatment for tinnitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-42n5gv2	Access to Radiofrequency Ablation for the Treatment of Thyroid Nodules and Thyroid Cancer	Recruiting	Intervention	2025-09-19	<NULL>	<NULL>	8291	Access to Radiofrequency Ablation for the Management of Thyroid Nodules and Thyroid Cancer in patients treated under the Brazilian Public Health System (SUS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Instituto do Câncer Arnaldo Vieira de Carvalho	Instituto do Câncer Arnaldo Vieira de Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-42n5gv2	<NULL>	"Benign Nodule Arm
Participants older than 18 years treated at Instituto do Câncer Arnaldo Vieira de Carvalho; patients with benign nodules classified as II by fine-needle aspiration biopsy (FNAB); nodules with a diameter greater than or equal to 3 cm; nodules with a diameter greater than or equal to 2 cm associated with compressive or aesthetic symptoms with surgical indication; participants who agree to participate in the study and sign the informed consent form (ICF); patients with at least 16 months of clinical follow-up after the start of treatment
Malignant Nodule Arm
Participants older than 18 years treated at Instituto do Câncer Arnaldo Vieira de Carvalho; patients with malignant nodules classified as V or VI by fine-needle aspiration biopsy (FNAB), i.e., suspicious for or consistent with papillary carcinoma; nodules with a diameter less than or equal to 1 cm with surgical indication; participants who agree to participate in the study and sign the informed consent form (ICF); patients with at least 16 months of clinical follow-up after the start of treatment"	"Benign Nodule Arm and Malignant Nodule Arm
Participants diagnosed with hyperthyroidism; participants without cognitive ability to understand the informed consent form"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-6zpvwty	Accuracy assessment between the digital bracket bonding system (CAD/CAM) and conventional systems	Recruitment completed	Intervention	2021-09-03	<NULL>	<NULL>	4860	Accuracy assessment between the digital bracket bonding system (CAD/CAM) and conventional systems	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Faculdade de Odontologia de São Paulo	Faculdade de Odontologia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6zpvwty	<NULL>	The sample selection criteria will be a young and adult male and female patients aged 12 to 25 years with a balanced profile, with erupted second molars, without missing teeth, enamel fractures or caries injuries. Class I or Class II occlusion patients with the molar relationship at most end-to-end, with or without crowding, all without prognosis for extractions	Patients older than 25 years old, presence of caries, absence of dental elements, malocclusion class II and class III complete periodontal diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-3h6n6c	Acidity effect of whitening gel on the effectiveness and sensitivity of teeth after in office bleaching	Recruitment completed	Intervention	2016-03-30	<NULL>	<NULL>	767	Effect of pH of the bleaching gel in the effectiveness and tooth sensitivity after in office bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-02	Centro de Ensino Superior dos Campos Gerais - CESCAGE	Centro de Ensino Superior dos Campos Gerais - CESCAGE	https://ensaiosclinicos.gov.br/rg/RBR-3h6n6c	<NULL>	Patients will be included in this clinical trial were men and women; who were in good general and oral health; were required to have six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade A2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany).	Patients will be excluded pregnant or lactating women; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-2n2nfp6	Acrylic splints for treating chronic muscle pain in patients with TMD: randomized clinical trial	Not yet recruiting	Intervention	2023-09-28	<NULL>	<NULL>	6467	Total and partial splints in the treatment of chronic myalgia in patients with TMD: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-2n2nfp6	<NULL>	Having myalgias related to Temporomandibular Disorders (TMDs) for longer than 6 months; myalgias located in the temporal region accompanied, or not, by other facial myalgias; be aged 18 years or over; both genders; pain on palpation with a score greater than or equal to 7 on the numeric rating scale; pain related to functional and/or parafunctional activities of the stomatognathic system	Patient undergoing physiotherapeutic and/or speech therapy treatments that have repercussions on muscle, joint and/or skeletal structures in the head and neck region; who have undergone some type of temporomandibular joint procedure in the last 12 months; patients with facial paralysis; patients undergoing orthodontic treatment; complete denture users; who underwent a procedure using botulinum toxin in the head and neck region in the last 6 months; patients using Selective Serotonin Reuptake Inhibitors (SSRI) antidepressants; patients undergoing psychological treatment; patients who have cognitive and/or neuromotor difficulties that compromise the stages of the study&apos;s development	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-5x69x2	Action of Acupuncture on the ear to reduce pain in muscles and bones	Recruiting	Intervention	2015-08-17	<NULL>	<NULL>	589	Contribution of Auricular Acupuncture for reduction chronic musculoskeletal pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-15	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5x69x2	<NULL>	Size of Target Sample: 200. Age (18 years or more); orientation in time; place and person; report the presence of chronic pain (existing for six months or more); score more than four on the Numerical Pain Intensity Scale; have availability of time for submission to auricular acupuncture sessions.	Have infection; inflammation or injury to the ear; make use of piercing (except ordinary earring); people who have allergies to metal or micropore; those who use other energy therapies (massage; herbal medicine; reiki; flower therapy); physical therapy in period of auricular acupuncture; make continued use of medication for pain relief; do not answer three tries against to the researcher; refuse to receive the headset processing with needles and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-7cs387	Action of Chinese Auricular Acupuncture with Laser associated with Systemic Cupping  in people with Chronic Spine Pain	Recruiting	Intervention	2018-12-12	<NULL>	<NULL>	2380	Action of Chinese Auricular Acupuncture with Laser associated with Systemic Cupping on Chronic Pain in people with Musculoskeletal Disorders in the Spine: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7cs387	<NULL>	Age (18-80 years old);  Presence of chronic pain, existing for three months or more; Self-reported pain intensity, with score ? four in the numerical pain intensity scale; and time availability for laser auricular acupuncture sessions.	Infection, inflammation or injury in the Auricular pavilion; Cancer patients; Piercing use (except normal earring); Previous energy therapy, such as massage, phytotherapy, reiki, floral therapy, yoga and homeopathy up to 3 months prior to the realization of the study; Physiotherapeutic treatment concomitant with the proposed intervention; Continuous use of medication for pain relief; neurological or psychiatric disease; Refusal to receive ear treatment by means of laser; Pregnant women and not responding to three attempts at contact made by the researcher.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-89q4ydz	Action of Curcuma Longa and Piperine on the oxidative and inflammatory profile of patients with Inflammatory Bowel Disease: a randomized, double-blind, placebo-controlled study	Terminated	Intervention	2023-07-20	<NULL>	<NULL>	6257	Effect of supplementation with Curcuma Longa (extract) and Piperine on inflammatory markers, oxidative stress and glycoxidation in patients with Inflammatory Bowel Disease treated at a Teaching Hospital in Alagoa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-02	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-89q4ydz	<NULL>	Patients diagnosed with IBD (Crohn&apos;s Disease, Ulcerative Colitis or Unclassified Colitis) of mild to moderate intensity; age equal to or greater than 18 years and up to 80 years; Patients using conventional drug therapy for IBD (aminosalicylates, immunosuppressants, biological); Function preserved kidney and liver	Pregnancy; Change or withdrawal of dosage/conventional medication for IBD; HIV positive patients and compromised renal and hepatic function; Patients who made inadequate use of supplementation (did not ingest the recommended daily dose)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-42gkzt	Action of low power laser on pain and quality of life and sleep in patients with fibromyalgia	not yet recruiting	Intervention	2012-02-14	<NULL>	<NULL>	90	Effect of low-level laser therapy on pain, quality of life and sleep in patients with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-42gkzt	<NULL>	"A clinical diagnosis of fibromyalgia based on American College of Rheumatology criteria;  
Cognitive level sufficient for understanding the procedures and following the instructions; 
Agreement to participate in the study and the signing of a statement of informed consent after receiving clarifications regarding the objectives of the study."	"Psychiatric disorders, history of drug abuse or other behaviors that require intervention psychiatric medication;
 Development of uncontrolled clinical situations that prevent participation in aerobic activities, for efforts or group activities;
 History of epilepsy, seizures, heart disease and arrhythmias;
 A pacemaker;
 Presence of undiagnosed pain;
 Pregnant women;
 Patients with malignant tumors."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-10b33dwf	Action of oral hydrating gel with menthol in small particles on thirst: a controlled clinical study	Recruitment completed	Intervention	2022-07-11	<NULL>	<NULL>	5477	Action on hydrating gel with microencapsulated menthol on thirst: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-10b33dwf	<NULL>	Be aged between 18 and 50 years old be of both sexes. Be fasting for 8 hours of solids and liquids	Being allergic to menthol Being allergic to one of the components of the product Present nausea or vomiting during the approach Present salivary dysfunctions Present lesions or dysfunctions in the oral cavity Having the flu or having a respiratory condition being a smoker or having chronic diseases such as hypertension and diabetes Present salivary dysfunctions present lesions in the oral cavity brush your teeth at least 2 hours before collection smoker drink alcoholic beverages for 24 hours perform physical exercises for 60 minutes before collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-58vsqp	Action of the Anti-Reflux Mattress Adapter in patients with Reflux Disease	Recruitment completed	Intervention	2017-11-14	<NULL>	<NULL>	3802	Influence of anti-reflux mattress adapter on the amount of gastroesophageal reflux in adult patients with symptoms of gastroesophageal reflux disease.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-13	Hemocentro de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-58vsqp	<NULL>	Volunteers with gastroesophageal reflux disease; both genders; age between 20 and 60 years; with symptoms of regurgitation and heartburn; with result of digestive endoscopy without other changes in the esophagus.	Volunteers with other changes in the esophagus; diagnosis of neurological, immunological, neoplastic and drug users for coronary diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-8zypz4p	Action of two forms of ozone therapy application on clinical and biochemical parameters after wisdom teeth extraction: clinical, triple blind and randomized study	Recruitment completed	Intervention	2023-12-13	<NULL>	<NULL>	6654	Influence of two forms of ozone therapy application on clinical and biochemical parameters after third molar extractions: clinical, triple blind and randomized study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-29	Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Odontologia de Araçatuba- FOA UNESP	https://ensaiosclinicos.gov.br/rg/RBR-8zypz4p	<NULL>	Patients with favorable systemic and local health conditions; be between 16 and 35 years of age; both genders; with indication of tooth extraction of the lower third molars (elements 38 and 48), in position A or B and Pell &amp; Gregory classification I or II, with at least 2/3 of the root formed	Mandibular third molars in position C and Pell &amp; Gregory classification III; signs of local manifestations such as pericoronitis, cysts and odontogenic tumors associated or not with the third molar, trauma in the region, presence of infection or periodontal disease; patients with any systemic disease that interferes with the results of the procedure or who cannot use the drugs present in the study; presence of a history of hypersensitivity to drugs present in the study and to products used in the procedure, such as: 0.5% alcoholic chlorhexidine solution, 0.12% chlorhexidine digluconate solution and 2% mepivacaine hydrochloride solution with epinephrine 1:100,000; women who are menstruating, pregnant or breastfeeding during the study period; patients using medications to control psychiatric diseases, corticosteroids, estrogens and androgens	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-3sbp54z	Action of water with ozone in dental implant surgery to reduce pain, swelling and difficulty opening the mouth	Recruiting	Intervention	2023-10-06	<NULL>	<NULL>	6489	Effect of using ozonated water during dental implant surgery on the control of healing, pain, edema and trismus: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-10	Faculdade Unidas do Norte de Minas	Faculdades Unidas do Norte de Minas - FUNORTE	https://ensaiosclinicos.gov.br/rg/RBR-3sbp54z	<NULL>	Patients over the age of 18 years; both gendres; without impairment of general health according to medical history and physical examination; patients with indication of placement of dental implants in the region of bilateral mandibular molars selected through clinical and radiographic examination	Patients classified as American Society of Anesthesiology (ASA) III or American Society of Anesthesiology (ASA) IV; use of anti-inflammatory drugs within 15 days prior to surgery; submitted to antibiotic therapy in the last 2 months; patients with tuberculosis, leukocytosis, collagen vascular diseases, multiple sclerosis, HIV infection, and other autoimmune diseases; pregnant and lactating women; patients with cognitive disorders that make it impossible to understand and execute commands; withdrawal of consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-357dht4	Actions to Improve Well-Being and Reduce Emotional Problems at Work	Not yet recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8673	Effectiveness of Interventions to Promote Psychological Well-Being and Reduce Common Mental Disorders among Workers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Fundação Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Workers of both sexes; aged 18 years or older or emancipated; active employment link in one of the selected industrial sector companies distributed across the Regional Departments of the Social Service of Industry; signature of the Informed Consent Form	Absence from work activities due to vacation or leave of any kind during the data collection period; non-completion of the data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-7tvhq8	Actions to prevent pain and injury in the nipple during breastfeeding.	Recruiting	Intervention	2019-01-07	<NULL>	<NULL>	2426	Comparative study of an intervention for the prevention of pain and nipple trauma in breastfeeding.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-15	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7tvhq8	<NULL>	Have a desire to breastfeed; Be in prenatal care; Have gestational age between 35 and 37 weeks, calculated from the date of the last menstrual period or first trimester ultrasonography; Be 18 years of age or older; Have a fixed or mobile phone, for contact.	Anatomical alterations of the nipples that favor nipple trauma (inverted nipple, pseudoinverted); Residence outside the municipality of Goiânia - GO; Do not adhere to the proposed protocol on 4 consecutive days, or use another concomitant intervention; To present adverse effects to the proposed intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-4wfh7y	Activation Following the evaluation of the hip muscles and lumbar spine after the application of techniques to relief back pain	Recruitment completed	Intervention	2017-04-05	<NULL>	<NULL>	1205	Activation sequence of the evaluation of lumbopelvic muscles after application of analgesia techniques	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-27	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4wfh7y	<NULL>	male and female; aged  20-60 years old, body mass índex: 18 - 25 kg / m2 ; screening performed in Spinal Outpatient Clinic Maria da Glória of the Federal University of Triangulo Mineiro; sedentary or regular physical activity practitioners will be forwarded to the Glory Marida Clinic of the Federal University of Triangulo Mineiro; persistent pain between the last rib and the gluteal fold in a period exceeding three months; no history of previous spinal surgery, spinal fractures, neurological disorders, tumors, osteoporosis and arthrosis advanced; complain of pain greater than 0 in the visual analogue scale; not present diagnosis of psychiatric disorder, cognitive impairment or difficulties in understanding and communication that could compromise the use of electrotherapy or spinal manipulation	Diagnosis of a new disease or trauma to the spine and / or lower limbs in the period between the intervention and the follow-up study; fouls two consecutive sessions during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-9pkxn2	Active Life: discovering healthy paths	Data analysis completed	Intervention	2019-09-05	<NULL>	<NULL>	2929	Active Life: discovering healthy paths	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-16	Universidade Federal de Santa Catarina	Illinois University of Urban-Champaign	https://ensaiosclinicos.gov.br/rg/RBR-9pkxn2	<NULL>	"Study participants were men and women aged 60 or older;
no severe physical and/or mental health impairments;
not participate in physical activity programs in the past six months."	"Heart attack and/or stroke in the past six months;
cancer diagnosis in the past six months;
other severe medical conditions in the past six months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-92m2m9	Active mind: cooking and gardening class for healthy aging	Recruitment completed	Intervention	2019-12-10	<NULL>	<NULL>	3268	Envelhecimento saudável com oficinas de culinária e horta: um estudo de intervenção para idosos da coorte EPIDOSO	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de São Paulo	Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92m2m9	<NULL>	To be eligible should be participant from the EPIDOSO cohort study; aged people more than 60 years old; Clinical Dementia Rating (CDR) scored zero or half; respectively; no dementia and questionable dementia; both sexes.	Dementia diagnosed by trained gerontologist with Clinical Dementia Rating -CDR (CDR=1 is mild dementia, CDR=2 is moderate dementia and CDR=3 is severe dementia); depression (escala de depressão em idosos-GDR=5); gastrectomia; HIV positive; alcoholist; chronic renal failure; multiple sclerosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-95wytq8	Active Oxygen Gel to improve healing and reduce pain after Frenectomy	Recruiting	Intervention	2026-02-02	<NULL>	<NULL>	8822	Effects of Active Oxygen-Releasing Gel and Lactoferrin on the healing and analgesic process in Frenectomy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-07	Universidad Jose Antonio Paez	<NULL>	<NULL>	<NULL>	Patients of both sexes; older than 18 years; without systemic diseases; with a diagnosis of papillary frenulum or aberrant frenulum or with an indication for frenectomy due to orthodontic, prosthetic or aesthetic reasons; who voluntarily agree to participate and sign the informed consent form	Patients under legal age; patients with systemic inflammatory diseases; patients with smoking-related disease or conditions that interfere with the healing process; diabetic patients; patients with periodontal disease; patients undergoing chemotherapy or radiotherapy to the head and neck region	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-103bky8r	Activity of carvacrol and thymol in controlling bacterial accumulation on teeth and gum bleeding	Data analysis completed	Intervention	2025-11-19	<NULL>	<NULL>	8543	Activity of carvacrol combined with thymol in the control of supragingival dental biofilm and gingival bleeding: a longitudinal randomized clinical study	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-12-10	Departamento de Clínica Odontológica	<NULL>	<NULL>	<NULL>	Healthy volunteers; both genders which does not constitute a bias for this study; non-smokers; absence of dental caries; age between 18 and 60 years as they are adults; having 20 or more teeth in the oral cavity; presence of supragingival dental biofilm; presence of bleeding on probing; signing a free and informed consent form	Smoker volunteers; those who have used antibiotics in the last 3 months; those who present clinically detected periodontitis by periodontal probing and radiographic examination (serial imaging); presence of soft tissue lesions in the oral cavity; patients who present sites with &gt;=4mm probing depth; those who present teeth with extensive caries involving at least 10 teeth; holders of orthodontic devices; holders of ceramic or acrylic prostheses at least 10 dental crowns; patients who showed difficulties attending the clinic for periodic evaluations until the end of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:02
RBR-9x957k	Activity of the shoulder muscles during the development of the throw with speed and accuracy	Recruitment completed	Intervention	2017-07-19	<NULL>	<NULL>	1300	Electromyographic activity of the shoulder muscles during the development of the throw with speed and accuracy	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9x957k	<NULL>	Participants who do not have dysfunction history in the shoulder complex; present shoulder elevation range of motion of at least 150 degrees.	history of rotator cuff surgery, fractures of the clavicle, scapula and humerus, systemic diseases involving the joints, cognitive deficits that prevent understanding of commands to perform the task, injury that affects the brachial plexus or the system central nervous and the presence of developmental delay according to the account of the parents;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-66mcspw	Acupuncture and Cognitive-Behavioral Psychotherapy for the treatment of Anxiety in women	Data analysis completed	Intervention	2025-10-11	<NULL>	<NULL>	8391	The use of Integrative and Complementary Practices in the Brazilian Unified Health System for the treatment of Anxiety in women of reproductive age	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Organização Mogiana de Educação e Cultura Sociedade Simples Ltda	Organização Mogiana de Educação e Cultura Sociedade Simples Ltda	https://ensaiosclinicos.gov.br/rg/RBR-66mcspw	<NULL>	Women; aged between 18 and 49 years; with a clinical diagnosis of anxiety according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); presenting moderate to severe symptoms measured by the Hamilton Anxiety Rating Scale (HAM-A)	Pregnant women; women using anxiolytic or antidepressant medication; those undergoing other forms of psychotherapy or acupuncture; women with severe psychiatric or neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-72qkvy	Acupuncture and Phytotherapy in Anxiety control	Recruiting	Intervention	2019-07-23	<NULL>	<NULL>	2841	Acupuncture and Phytotherapy in anxiety control with accompanying by the Bioeletrography technique	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-72qkvy	<NULL>	Individuals over 18 years of age with anxiety and / or VAS complaints for anxiety greater than 4.	Individuals who perform some drug treatment for anxiety and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-10q9pcb7	Acupuncture and reiki in the treatment of Depression and Alcohol or Drug Abuse	Recruiting	Intervention	2023-05-25	<NULL>	<NULL>	6106	Effectiveness of acupuncture and reiki in coping with Depression and Substance Abuse	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10q9pcb7	<NULL>	Depression: both genders; aged over 18 years; minimum depression score at moderate level on the Depression Anxiety Stress Scale. Substance use disorder: both genders; aged over 18 years; minimum pattern of alcohol risk consumption by the Alcohol Use Disorders Identification Test; moderate problem in the consumption of other drugs by the Drug Abuse Screening Test	Use of medication to treat symptoms of depression or anxiety or alcohol or other drug use; being undergoing psychological treatment; be performing any other alternative practice for the treatment of the symptoms to be treated in the study; not being present in at least six meetings out of the total of eight; refusal to receive the technique in which he was randomly included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-7sbzxw	Acupuncture as a complementary treatment for high blood pressure	Recruitment completed	Intervention	2016-06-03	<NULL>	<NULL>	883	Acupuncture as applied technology to nursing Care adult hypertensive: an Experimental Study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-01	Universidade Federal do Rio de Janeiro	Secretaria Municipal de Saúde Vitória / ES	https://ensaiosclinicos.gov.br/rg/RBR-7sbzxw	<NULL>	Be suffering from essential hypertension exclusively; be properly prescribed medication and have difficulty controlling blood pressure keeping regular measurement above was over 140x90mmHg.	Being pregnant; be in possession of any kind of active neoplasia; being a smoker; be alcoholic; not dieting for weight loss; practice regular physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-4y8vd2	Acupuncture as another treatment option for women who have Pain in the belly foot and Muscle Pain in the belly that did not improve with the Injection of Anesthetic at the pain site	Data analysis completed	Intervention	2017-06-19	<NULL>	<NULL>	1258	Acupuncture as an alternative method for the treatment of women with Chronic Pelvic Pain and Myofascial Syndrome not-responsive to Topical Injectable Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-11	Faculdade de Medicina de Ribeirão Preto / Universidade de São Paulo - FMRP/USP	Faculdade de Medicina de Ribeirão Preto / Universidade de São Paulo - FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-4y8vd2	<NULL>	Women with diagnostic criteria for chronic pelvic pain secondary to abdominal myofascial syndrome; Presence of only one active trigger point on the abdominal wall, have not undergone previous treatment with topical injectable block or acupuncture, age above 18 years and premenopausal, visual analogue scale with a value above 4.4 (moderate pain)	Women with anticoagulation or hemorrhagic disorders, local or systemic infections; Allergy to anesthetics, acute muscle trauma, extreme fear of needles; History of complaints of chronic musculoskeletal pain such as fibromyalgia, chronic fatigue or diabetes; Aspirin intake within 3 days after injection; All patients with suspected endometriosis, interstitial cystitis, irritable bowel syndrome, or other disease that warrants or contributes to chronic pelvic pain; Endometrioma or hernia evidenced by ultrasound of the abdominal wall, infections of the abdominal wall, lack after the beginning of the treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-5zbgpp	Acupuncture as Treatment of Cervical Wound and Avaliation of Regeneration Process Factors	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1547	Treatment of Cervical Gladular Epithelium Ectopy with Sistemic Acupuncture and Analisys of Interference Factors in the Metaplasic Process	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5zbgpp	<NULL>	women in the menamma with ectopy of the cervical glandular epithelium on the cervical surface in the vaginal environment without any previous treatment	non-pregnant, non-lactating, nonimmunosuppressed of any kind	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-9tsmpp	Acupuncture associated with electrotherapy and running in the decreased localized fat	Recruitment completed	Intervention	2018-05-25	<NULL>	<NULL>	1849	Acupoint electropolysis and aerobic activity in the reduction of localized adiposity in women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal de Alfenas - UNIFAL	Universidade Federal de Alfenas - UNIFAL	https://ensaiosclinicos.gov.br/rg/RBR-9tsmpp	<NULL>	University students; women; age between 18 and 30 years; White breed; been sedentary for two months; presence of abdominal adiposity and flank region; Body Mass Index classified as normal or overweight	Women in dermatological-functional treatment to reduce localized adiposity; patients with cardiac, respiratory, diabetes mellitus, systemic arterial hypertension and neoplasias; patients unable to provide sensitive feedback or with changes in cutaneous sensitivity; aversion or allergy to the use of electrical stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-2ckx5s	Acupuncture Ear ins students from an Internacional University	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2726	Auriculotherapy in academics from an International University	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Diego da Silva Ferreira	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2ckx5s	<NULL>	Students who are regularly enrolled and active in the classroom graduation courses. Accept to participate in the research. 18 years or older. Availability of time for submission to auriculotherapy sessions. They obtained high scores of signs of anxiety, stress and depression on the EADS scale. Low index in the quality of life questionnaire.	Students who are performing other energy therapy. They make use of anxiolytics and antidepressants. Pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-5q9svp	Acupuncture evaluation in treatment of pain related to articulation of the chewing region.	Recruiting	Intervention	2017-01-09	<NULL>	<NULL>	1137	The evaluation of Acupuncture effectiveness in the treatment of chronic pain associated with temporomandibular disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5q9svp	<NULL>	Agree to sign the consent form;Diagnosed with muscular TMD, joint or mixed, according to the criteria of the RDC-TMD;In the age group between 20-65 years;Both sexes;Symptomatic pain for more than six months	"With a rheumatic diseases history affecting the muscles and joints;psychiatric or neurological conditions that complicate the diagnostic process;surgical implants for treatment of TMD;
Blood coagulation disorders;Needle Phobia;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-9px8h63	Acupuncture for breast cancer pain: study with women	Not yet recruiting	Intervention	2026-04-20	<NULL>	<NULL>	9123	Effects of Auricular Acupuncture on the treatment of cancer pain in women with Breast Cancer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; be a woman; be undergoing treatment for breast cancer, regardless of the type of oncological therapy; have undergone surgery for the disease prior to the study, at least three months and at most 10 years earlier; report pain that began after surgery, with an intensity greater than or equal to 4 points on the Numeric Rating Scale (NRS)	Present metastasis; have cognitive impairment that precludes responding to the study instruments; be using high doses of anticoagulants; have undergone auricular acupuncture treatment for cancer-related pain within the three months prior to the study; present ear piercings near the auricular points to be used in the study; report a history of allergy to needles, seeds, or microporous tape; present lesions, inflammation, deformity, or tattoos on the ear; or use a hearing aid	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-8km9qs7	Acupuncture for the treatment of anxiety among nursing professionals during the fight against Covid-19	Recruitment completed	Intervention	2024-06-20	<NULL>	<NULL>	7078	Innovation in supporting nursing professionals in coping with Covid-19 through Acupuncture	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-27	Universidade de São Paulo	Universidade Federal Do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8km9qs7	<NULL>	Nursing staff (nurse, nursing technician or nursing assistant) from the urgency and emergency unit or sector that cares for patients with suspected or confirmed Covid-19. Working professionals, allocated to the sector studied. Health professionals who present some level of anxiety, according to the instrument to be applied previously	People who show signs or symptoms of COVID 19 at the time of data collection or intervention. People who leave the selected sector or are dismissed from the institution during data collection. Those who did not want to answer the mandatory questions for the study. Those who miss two sessions in a row or miss without justification	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-58yq52	Acupuncture in Multiple Sclerosis	data analysis completed	Intervention	2012-04-16	<NULL>	<NULL>	132	Impact of electroacupuncture on quality of life for patients with Relapsing-Remitting Multiple Sclerosis under treatment with immunomodulators	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Departamento de Clinica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas - UNICAMP	Juan G. Quispe-Cabanillas	https://ensaiosclinicos.gov.br/rg/RBR-58yq52	<NULL>	Patients with a confirmed diagnosis of RRMS according to the revised 2005 McDonald criteria and under treatment with immunomodulatory drugs (interferon-beta and glatiramer acetate) were selected.	Those individuals who had previously received acupuncture treatment were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-2gq7mqr	Acupuncture in muscle fatigue	Not yet recruiting	Intervention	2022-03-29	<NULL>	<NULL>	5362	Effect of acupuncture on muscle fatigue	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-03	Faculdade Motricidade Humana	Faculdade Motricidade Humana	https://ensaiosclinicos.gov.br/rg/RBR-2gq7mqr	<NULL>	Healthy men; aged between 18 and 30 years; practicing regular physical exercise, at least twice a week	Recent lower limb injuries; lower limb prosthesis; Body Mass Index &gt;25; use of muscle myorelaxant; needle phobias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-7cfctd	Acupuncture in pain and quality of life of women with irregular menstruation	Recruitment completed	Intervention	2016-03-07	<NULL>	<NULL>	740	Acupuncture in clinical manifestations of Endometriosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	UDESC- Universidade do Estado de Santa Catarina	HU- SC Hospital Universitário Professor Polydoro Ernani de São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-7cfctd	<NULL>	"The sample provides 42 women aged between 18 and 45 years; with endometriosis; who have signs and symptoms such as pelvic pain; dyspareunia; and deficits in quality of life for at least 1 year.
As are 21 women in the experimental group and 21 in the control group the total sample will include 42 women."	Fear of needles; use of anti-inflammatory or analgesic; physical therapy for pelvic floor.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-3cpwwt	Acupuncture in pain patients with Chronic Kidney Disease	Recruitment completed	Intervention	2020-02-28	<NULL>	<NULL>	3538	Effect of Acupuncture on Chronic Renal pain patients in hemodyalysis: randomized trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-06-06	Geórgia Alcantara Alencar Melo	Geórgia Alcantara Alencar Melo	https://ensaiosclinicos.gov.br/rg/RBR-3cpwwt	<NULL>	"The criteria
for inclusion were: age between 30 and 60 years; with over a year of dialysis therapy; that is registered
in the clinic through the SUS; with moderate pain assessed from the analog pain scale; with punctuation
on the Glasgow scale of 15; with preserved hearing acuity through propaedeutic tests
Weber and Rinne Test); and preserved cognitive function assessed by the Mini Mental State Examination
(MEEM)."	"Mental deficiency diagnosed; use of another method of practice
complementary alternatives; use of opioids; have a dermatological lesion or absence of limb at the
application; and being pregnant. Discontinuity criteria: Participants wish not to continue in
research after first session; present any unpleasant reaction associated with the treatment; no
agree that needles are inserted at some point; have taken analgesic or relaxing medication
muscle in the last 12 hours prior to the session; no participation in two more acupuncture sessions, either for hospitalization, hemodialysis session absence or other reason."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-9kwjgx	Acupuncture in the care of nausea and vomiting after surgery	Not yet recruiting	Intervention	2017-04-17	<NULL>	<NULL>	1215	The use of acupuncture in the prevention of nausea and vomiting postoperative	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Departamento de Anestesiologia da Faculdade de Medicina da Universidade Estadual Paulista	Faculdade de Medicina da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9kwjgx	<NULL>	female patients , aged 18 to 65 years , physical status I and II according to the American Society of Anesthesiologists ( ASA ) , undergoing abdominal elective gynecological surgery ( hysterectomy) under total intravenous anesthesia.	patients under 18 years , ASA III or IV , unable to report or respond to protocol , fear of acupuncture needle , inability to use P6 ( Neiguam ) , patients using a different antiemetic protocol .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-5vrgch	Acupuncture in the Complementary Treatment of Diabetes Mellitus Type II	Data analysis completed	Intervention	2016-09-22	<NULL>	<NULL>	1013	Acupuncture in the Complementary Treatment of Diabetes Mellitus Type II	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-03	Universidade Federal do Rio de Janeiro	Secretaria Municipal de Saúde Vitória / ES	https://ensaiosclinicos.gov.br/rg/RBR-5vrgch	<NULL>	be aged between 30-75 years; Be in possession of Diabetes Mellitus Type II only; Be in drug treatment for at least 1 year properly prescribed (to be confirmed with the medication of revenue); Report difficulties in glycemic control, regular saving measures higher than recommended by the Brazilian Society of Diabetes (postprandial up to 180mg / dl).	have any of the lower limb amputee or part thereof (due to the location of the selected acupoints to the treatment protocol); Be insulin ; Being a smoker;Be alcoholic; Be in drug treatment for other diseases including obesity ; Be making specific diet for weight loss; Practicing regular physical activity; Be in possession of cancer; Being pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-9kj5nk	Acupuncture in the improvement of Inflammation of the gums in women with Diabetes	Recruitment completed	Intervention	2018-12-27	<NULL>	<NULL>	2413	Acupuncture in the improvement of Gengivite in women with Diabetes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-16	Universidade Federal do Piaui UFPI	Universidade Federal do Piaui UFPI	https://ensaiosclinicos.gov.br/rg/RBR-9kj5nk	<NULL>	Diabetic women who presented gingivitis after evaluation of the Gingival Bleeding Index.	Diabetic patients with healthy gingiva and diabetic patients with edentulous.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-88hg3bh	Acupuncture on the control of nausea and vomiting in patients undergoing Bariatric Surgery in a private hospital in São Luís-Ma	Not yet recruiting	Intervention	2025-10-03	<NULL>	<NULL>	8355	Effect of acupuncture on the control of nausea and vomiting in patients undergoing Bariatric Surgery in a private hospital in São Luís-Ma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-88hg3bh	<NULL>	Patients undergoing bariatric surgery; aged 18 or over; with assessment of postoperative nausea and vomiting will be included in the study	Those who do not consent to participate in the research; contraindications to acupuncture techniques such as rash at the point of stimulation on the skin or systemic infection; severe obstructive sleep apnea syndrome; uncontrolled systemic diseases of the heart, lung, kidney or liver; coagulation disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-5s4czx	Acupuncture to treat the symptoms of Premenstrual Syndrome - randomized controlled study	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1807	Acupuncture as a therapeutic resource for treatment of symptoms of Premenstrual Syndrome - a randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade de Mogi das Cruzes	Universidade de Mogi das Cruzes	https://ensaiosclinicos.gov.br/rg/RBR-5s4czx	<NULL>	Will include women aged between 18 and 40 years; presence of at least one physical symptom and one emotional symptom in the pre-menstrual and/or menstrual period observed in the two cycles prior to the study in non-users or users of oral contraceptives and who present three regular menstrual cycles before the study.	Women who use anxiolytics or antidepressants will not be included; with liver diseases; carriers of coagulation disorders, oophorectomized; carriers of cancer or serious diseases; carriers of psychiatric illnesses; history of radiation therapy or chemotherapy; illicit drugs and/or excessive alcoholic beverages, pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-8df2h4	Acupuncture treatment in elderly people with loss of muscle mass: effects on the strenght and inflammatory mediators	Data analysis completed	Intervention	2018-12-27	<NULL>	<NULL>	2409	Effects of acupuncture on the muscular strength of elderly patients with sarcopenia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-14	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8df2h4	<NULL>	male and female seniors; sedentary; who were not under acunpuncture treatment during the survey period.	Individuals who were afraid of needles; with mobility problems that prevented them to attend the data collection and processing location; who presented difficulties of understanding the treatment and the applied tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-29bt5qt	Acupuncture treatment of people with residual symptoms of COVID-19 infection	Recruitment completed	Intervention	2022-02-15	<NULL>	<NULL>	5215	Treatment of patients with sequelae of COVID-19 using acupuncture - a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-19	Hospital do Servidor Público Municipal	Hospital do Servidor Público Municipal	https://ensaiosclinicos.gov.br/rg/RBR-29bt5qt	<NULL>	Patients with sequelae of COVID-19 who agree to sign the free and informed consent form.	Patients with severe psychiatric problems, with surgical indication, with serious illnesses that require emergency care or with acute coronavirus disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-5ky5kfc	Acupuncture with Electrical Stimulation in the treatment of Tinnitus	Recruitment completed	Intervention	2021-08-13	<NULL>	<NULL>	4832	Electroacupuncture in the treatment of Tinnitus	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal da Paraíba (UFPB)	Mayra Ferreira de Freitas Montenegro	https://ensaiosclinicos.gov.br/rg/RBR-5ky5kfc	<NULL>	Volunteers of both sexes; age from 18 years onwards; diagnosis of chronic tinnitus for at least six months; refractory to previous treatments	Volunteers complaining of hearing loss; use of pacemakers or other electronic implants; severe heart disease; pregnant; previous electroacupuncture treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-9qnxb9z	Acupuncture&apos;s effect on blood pressure in Prehypertensive and stage I Hypertensive patients with low cardiovascular risk	Recruiting	Intervention	2024-02-29	<NULL>	<NULL>	6819	Acupuncture&apos;s effect on blood pressure levels in Prehypertensive and stage I Hypertensive patients with low cardiovascular risk	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-15	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9qnxb9z	<NULL>	Patients aged 18 years or over; prehypertensive or stage 1 hypertensive patients at low cardiovascular risk; not taking antihypertensive medication; evaluated at the screening consultation	Patients with stage 2 or 3 arterial hypertension or stage 1 arterial hypertension of moderate or high cardiovascular risk; using any medication with a known influence on blood pressure; diabetics; nephropaths; patients with a history of coronary artery and/or cerebrovascular disease; heart failure and/or thyroid diseases; with any condition that impairs the afferent and efferent conduction of nervous stimulation; severe blood dyscrasias; use of anticoagulants; skin lesions and/or any condition that makes access to the described acupoints impossible; pregnant and lactating women; with not controlled psychiatric illnesses ; who have received antihypertensive drug treatment in the last 6 months or who have already undergone acupuncture at some point in their lives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-9y32yy	Acute and chronic cardiovascular and respiratory changes in COVID-19 hospitalized patients and the effect of physical rehabilitation supervised by telecommunication	Not yet recruiting	Intervention	2020-05-24	<NULL>	<NULL>	4104	Acute and chronic cardiorespiratory changes in COVID-19 hospitalized patients: role of endothelial function and cardiovascular health in clinical-functional outcomes and effect of physical telerehabilitation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Estadual Paulista - UNESP	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-9y32yy	<NULL>	At least 100 adult patients (aged over 18 years), of both sexes, diagnosed with COVID19 in molecular biology exam, admitted (intensive care unit or infirmary) to referral hospitals in the state of São Paulo will be evaluated. According to the phases of the study, and for inclusion, volunteers must: PHASE 1 (to assess endothelial function and functional capacity): present hemodynamic and respiratory stability; not having the need for emergency medical care; not to be at imminent risk of death. The inability to express consent to participate in the study will not be considered an exclusion criterion, however, in this case, the informed consent form must be signed by the legal guardian. PHASES 2 and 3: not being pregnant; not be lactating. Patients with decompensated cardiovascular and/or pulmonary disease, and/or pacemaker users, and/or who have absolute contraindications for physical exercise (acute myocardial infarction; unstabilized unstabilized angina; uncontrolled cardiac arrhythmias with repercussion will not be included) hemodynamic; symptomatic severe aortic stenosis; uncontrolled symptomatic heart failure; acute pulmonary embolism or pulmonary infarction; acute myocarditis or pericarditis; acute aortic dissection).	Exclusion criteria will include: important hemodynamic and/or electrocardiographic changes during the cardiopulmonary stress test; need for hospital readmission; failure to meet 60% of scheduled interventions. Even if exclusion occurs during the phases, these patients will still be followed up by telephone, up to 12 months, to assess out-of-hospital outcomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-9c8wng	Acute and chronic cardiovascular responses to resistance training in individuals with intermittent claudication	Recruiting	Intervention	2014-12-09	<NULL>	<NULL>	363	Acute and chronic cardiovascular responses to resistance training in individuals with intermittent claudication	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-10-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9c8wng	<NULL>	Aged 45 to 85 years; both genders; be on stage II of Peropheral Artery Disease in one or both limbs, according with Fontaine criteria; be able to walk on a treadmill at least two minutes at a speed of 3.2 km/h; and, be with systolic and diastolic blood pressure levels less than 160 and 105 mmHg, respectively	Individuals who are in use of beta-blockers, calcium channel blockers or vasodilators non-dihidropiridinico; presenting complex arrhythmias or ischemia that contraindicate physical activity; having diabetes with complications or autonomic dysfunction, who are obese and they have amputated limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-3cb6qtz	Acute Cajuína (Anacardium occidentale L.) intake does not improve Leukocyte count, Lipid peroxidation, and Physical performance in Runners: a double-blind, crossover, randomized, placebo-controlled clinical trial.	Data analysis completed	Intervention	2023-11-17	<NULL>	<NULL>	6586	Effects of Cajuína on biochemical, physiological, and cognitive markers in Runners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-12	Universidade Estadual Vale do Acaraú	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3cb6qtz	<NULL>	absence of any health-related conditions; no use of nutritional supplements for at least three months, including the duration of the study; non-smokers or drinkers; participation in national and state competitions in recent months; ability to complete a 10-km run in less than 60 minutes	consumers of cashew juice, cajuína, or any other product containing polyphenols such as grape, red wine, and cocoa; myotendinous injury during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-68q84r	Acute effect of  electrical stimulation on Parkinsonian tremor inhibition	Not yet recruiting	Intervention	2020-09-03	<NULL>	<NULL>	4215	Acute effect of transcutaneous electrical stimulation on Parkinsonian tremor inhibition: A crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-68q84r	<NULL>	Volunteers with a proven diagnosis of Parkinson&apos;s Disease (PD); having hand tremors; having no associated diseases and accepting to participate in the research.	Volunteers with pacemakers; cardiac arrhythmias; pregnant women; metallic prosthesis in the area to be stimulated; uncontrolled hypertension; neoplasms; or any other contraindication for applying electric current.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-3w4xbv	Acute effect of a breath test on heart rate variability and diaphragm muscle mobility in heart transplant recipients	Recruiting	Observational	2020-08-20	<NULL>	<NULL>	4144	Acute effect of the incremental inspiratory load protocol on a frequency variability and diaphragmatic mobility among adults healthy and heart transplanted	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-02-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3w4xbv	<NULL>	This study will include adult individuals aged between 18 and 65 years old; of both sexes; who has had heart transplant surgery over a period of 12 months; sedentary; with clinical stability; making regular use of immunosuppressive therapy; no change in medication class within three months prior to the start of the research. Those healthy adult individuals between 18 and 65 years old will be included; sedentary; non smokers; non-drug user; without cardiac involvement.	"Patients using pacemakers will be excluded; with HF reactivation or Chagas disease; smoker; alcoholism; using corticosteroids; with obstructive disorder. In addition to patients who present psychological changes that make it impossible to understand the commands required for evaluation.
All patients with orthopedic diseases will be excluded; musculoskeletal; neurological or respiratory problems that make it impossible to perform the incremental load test; diabetes; patients who induce dialysis or cardiovascular disease; in addition to patients who have psychic changes that make it impossible to understand the commands required for evaluation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-3q6j7x	Acute effect of a Futsal Match on mood status, memory and attention in individuals with Chemical Dependence	Data analysis completed	Intervention	2019-08-27	<NULL>	<NULL>	2902	Emotional states, Physical Exercise and cognitive functions in people with Alcohol and Drug use Disorder in the CAPS ad	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-26	Centro Universitário Católico Salesiano Auxilium	Centro Universitário Católico Salesiano Auxilium	https://ensaiosclinicos.gov.br/rg/RBR-3q6j7x	<NULL>	The inclusion criteria were: male gender; aged between 18 and 45 years; diagnosis of drug dependence, guided by the International Classification of Diseases (ICD-10) regardless of the time of treatment and dependence; no health restrictions and limitations identified by the PAR-Q questionnaire; and no impairment in mental state identified by the mini-mental state examination.	The exclusion criteria were: to present physical or mental limitations that prevented participation in the futsal match	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-7dx6s84	Acute effect of breaking up prolonged sitting time with two different intensities on cardiovascular parameters and muscle activity: a randomized crossover clinical trial	Recruitment completed	Intervention	2025-12-19	<NULL>	<NULL>	8670	Cardiometabolic and cardiovascular responses, strength, and muscle electrical activity during multistage sitting time in adults	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-09	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Healthy adults aged 18 to 59 years; regularly enrolled as university students; with no diagnosis of chronic diseases; no continuous use of medications or any ergogenic aid; and no injuries or conditions that would prevent prolonged sitting or walking	Failure to complete any stage of the study; including screening, baseline assessments; or any of the experimental sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-6vhp5fq	Acute effect of breaking up sitting time on selective attention and memory: randomized crossover clinical trial	Recruitment completed	Intervention	2026-04-22	<NULL>	<NULL>	9127	Acute effects of interruptions in sitting time on cardiovascular parameters, muscle activity, and cognition in healthy adults	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Healthy adults aged 18 to 59 years; regularly enrolled as university students; without diagnosis of chronic diseases; without continuous use of medications or any ergogenic aids; and without injuries or conditions that could prevent prolonged sitting or walking.	Failure to complete any stage of the study including screening assessments baseline evaluations or any of the experimental sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-9wd3tt	Acute effect of cervical spinal manipulation on muscle strength: randomized clinical trial	Recruitment completed	Intervention	2019-09-16	<NULL>	<NULL>	2945	Effects of joint manipulation of the spine	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade do Estado do Amazonas	Centro Universitário do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9wd3tt	<NULL>	The individuals who were present at the University, volunteers, adults, who were asymptomatic about pain in the cervical region and signed the informed consent form were included.	Exclusion criteria were the absence of dysfunction in the cervical region when the evaluator applied the intervention, in addition to those who presented a positive response to the vertebral artery test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-964r2d	Acute Effect of Coffee Intake on Blood Pressure and Endothelial Function in Uncontrolled Hypertensive patients.	Recruiting	Intervention	2020-01-13	<NULL>	<NULL>	3822	Acute Effect of Coffee Intake on Blood Pressure and Endothelial Function in Uncontrolled Hypertensive patients.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-964r2d	<NULL>	Age between 40 and 65 years; both sexes;With body mass index (IMC) between 20 and 35 Kg/m2; diagnosis of arterial hypertension in treatment Regular with antihypertensive for at least 4 weeks; resenting systolic 140 mmhg and/or diastolic PA 90 mmhg	"will be excluded
Patients with evidence of hypertension
Secondary In use of blockers, statins, nutritional supplements or replacement therapy
Hormonal With PA 160/100 mmHg; You don&apos;t
Consume coffee habitually or present excessive consumption (&gt; 4 cups tea/day); Smokers
Presenting coronary disease clinically
Evident, diabetes mellitus, prior history of acute infarction and/or myocardial revascularization, clinical signs
Heart failure, arrhythmia or
Significant valve disease, previous stroke, thyroid function changes, disease
Renal or liver chronicles and history of
Cancer for the last five years."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-9tqpsvy	Acute effect of core stability and sensory-motor exercises on postural control during sitting and standing positions in young adults	Data analysis completed	Intervention	2021-01-07	<NULL>	<NULL>	4466	Analysis of the impact of motor sensory exercises and lumbar stabilization in neuromuscular responses during sitting and standing position in adults and elderly.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Norte do Paraná	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9tqpsvy	<NULL>	Both sexes; be healthy; did not participate in physical exercise programs	Present low back pain; absence of any musculoskeletal, joint or overall health conditions that limit implementation of the study protocol or not able to perform the proposed exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-3yv3bn	Acute effect of different ischemic preconditioning protocols on the speed of swimming athletes in a 100-meter race	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4413	Acute effect of different ischemic preconditioning protocols on the speed of swimming athletes in a 100-meter race: crossover study	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade Federal da Paraíba	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3yv3bn	<NULL>	Being male; swimming for at least 3 years; being between 14 and 19 years old, having no history of cardiovascular and pulmonary diseases; don&apos;t make use of stimulating substances; being out of the risk zone in the clinical examination of the brachial ankle index (ABI); not having osteomioarticular lesions	Present any cardiovascular, pulmonary or osteomioarticular worsening during the experiment; do not complete all sessions proposed by the study; in addition to giving up on it	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:10
RBR-74ffv8	Acute effect of different modalities of electric current therapy for the control of pain and temperature in people with Knee Osteoarthritis	Data analysis completed	Intervention	2018-10-25	<NULL>	<NULL>	7500	Immediate effects of different electrotherapy modalities in the control of pain and temperature of individuals with knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade de Ceilândia da Universidade de Brasília	Fundação de Ensino e Pesquisa em Ciências da Saúde da Secretaria de Estado da Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-74ffv8	<NULL>	Aged 60 years or older; engage in a minimum of 45 minutes per week of accumulated physical activity at a moderate intensity level; report a pain intensity equal to or exceeding 4 cm on a 10-cm visual analogue scale	Individuals who had undergone physiotherapy in the previous 3 months; received knee injections in the previous 6 months; had medical constraints, such as cardiorespiratory, neurological, or rheumatological dysfunctions; had undergone prior hip, knee, or ankle surgery; had chronic conditions leading to knee pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-103yr8h9	Acute effect of Electrical Stimulation applied to the scalp on pelvic floor muscle contraction function in healthy women	Data analysis completed	Intervention	2023-10-12	<NULL>	<NULL>	6502	Acute effect of Transcranial Direct Current Stimulation (electrical stimulation applied to the scalp) on the function of contraction (as if holding urine and then relaxing) of pelvic floor muscles (muscles that control urine and stool) in healthy women	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-09-05	Angela Cristina Ledur	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-103yr8h9	<NULL>	Healthy women; Nulliparous;18 and 45 years; sexually active in the last four weeks.	Participants who present any type of symptom or conditions that are linked to any change in the bladder, bowel and vagina/pelvis evaluated by the sample characterization form and applied questionnaire; chronic degenerative diseases; neurological disease; psychiatric disease; women who have undergone previous pelvic floor reeducation programs and/or pelvic floor surgeries for treatment of urinary infection or other conditions in the pelvic region; pregnant women; women with pacemaker or present any contraindications to the use of transcranial direct current stimulation; or present anesthesia or hyperesthesia at the transcranial direct current stimulation application site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-6tfbjjg	Acute effect of Electrical Stimulation of a body nerve located in the ear on heart rate and blood pressure in people with and without Hypertension	Recruiting	Intervention	2024-11-27	<NULL>	<NULL>	7541	Comparison of the acute effect of Transcutaneous Auricular Vagus Nerve Stimulation at two different sites on cardiac autonomic modulation and blood pressure in healthy and Hypertensive individuals: a randomized, crossover clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-11-03	Associação educacional nove de julho	Associação educacional nove de julho	https://ensaiosclinicos.gov.br/rg/RBR-6tfbjjg	<NULL>	Healthy individuals (without hypertension) and individuals with hypertension aged 18 years or older of both sexes; Mental State Examination as expected in relation to their level of education 13 points for illiterate 18 points for low/medium education and 26 points for high education	Presence of contraindications for Transcutaneous Auricular Vagus Nerve Stimulation (metal cochlear implant at the site of application); history of stroke; Coronary disease chronic obstructive or restrictive pulmonary; disease peripheral arterial disease hypo- or hypernatremia; hyper- or hypothyroidism; chronic atrial fibrillation; Diabetes Mellitus immune-dependent kidney disease chronicle	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-83kysp	Acute Effect of Full-Body Vibration in Women with Fibromyalgia	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2053	Acute Effect of Full-Body Vibration Stimulation in Women with Fibromyalgia	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Fundação De Amparo a Pesquisa de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-83kysp	<NULL>	Women aged 35 to 70 years; with confirmed diagnosis of fibromyalgia between 1 and 3 years; presence of sensitivity in at least 11 of the 18 specific pain points according to the American College of Rheumatology criteria.	Volunteers who present; any concomitant illness that may be exacerbated by physical activity; pregnancy; orthopedic limitations; inflammatory diseases; degenerative diseases; articular; respiratory or cardiovascular diseases; who are being followed up with a psychiatrist; who perform physical activity for the same 2 times a week; (acute hernia, thrombosis, diabetes, epilepsy, metabolic or neuromuscular diseases, orthopedic injuries and prosthetics); use immunosuppressive medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5g9j4pv	Acute effect of functional training on arterial rigidity and ambulatory blood pressure in elderly people with Hypertension	Not yet recruiting	Intervention	2025-04-04	<NULL>	<NULL>	7893	Acute effect of functional training on arterial rigidity and ambulatory blood pressure in elderly people with Arterial Hypertension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-17	Programa de Pós-Graduação em Educação Física - PPGEF	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-5g9j4pv	<NULL>	Elderly people; men and women; hypertensive; sedentary or who had not practiced any type of physical training in the month prior to the start of the intervention; not have uncontrolled heart failure; Parkinson&apos;s; Alzheimer&apos;s; insanity; physical or visual disability; morbid obesity; Cancer; unstable angina; musculoskeletal disorders that limit the performance of exercises; must be under treatment with antihypertensive medications; have medical follow-up; sign the Free and Informed Consent Form	Not completing the functional training session; failing to perform ankle brachial index (ABI) exams; not performing ambulatory blood pressure mapping (ABPM) in the pre- and post-intervention moments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-9zjgqm	Acute effect of ginger tea (Zingiber officinale) intake on energy metabolism, satiety sensation and prospective food intake	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3762	"Effect of allegedly thermogenic tea intake on metabolism energy, feeling full and food intake of individuals with excess of
Weight"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-29	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9zjgqm	<NULL>	Healthy volunteers; both genders; individuals with stable weight; non smokers; who do not use dietary supplements or medications that can interfere with the results of the study; aged between 18 and 40 years	Hypertensive; diabetic; carriers of diseases that affect energy metabolismo; allergic or sensitive to standard breakfast ingredients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-46gd7h3	Acute effect of high-intensity exercise on arterial stiffness in older adults: a randomized crossover clinical trial.	Not yet recruiting	Intervention	2025-11-21	<NULL>	<NULL>	8541	Acute response of arterial stiffness to anaerobic capacity in elderly individuals: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Older adults of both sexes aged 60 to 79 years, physically able to perform moderate to vigorous intensity physical exercise, and available to participate in the project’s scheduled activitie	The criteria that prevent participation are individuals with debilitating neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, or plegias; those with reduced intellectual capacity; individuals with severe cardiovascular diseases, including heart disease, arrhythmias, or uncontrolled hypertension; persons with medical contraindications to physical exercise, such as recent surgeries, joint prostheses, or musculoskeletal injuries; participants simultaneously enrolled in other clinical studies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:59
RBR-74497t	Acute effect of inspiratory muscle training on inflammation and heart function in patients with obstructive sleep apnea	Recruitment completed	Intervention	2020-03-23	<NULL>	<NULL>	3650	Acute effect of inspiratory muscle training on inflammatory markers, cardiac autonomic activity and cardiovascular variables in patients with obstructive sleep apnea: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-20	Universidade Federal de Pernambuco	Hospital Otávio de Freitas	https://ensaiosclinicos.gov.br/rg/RBR-74497t	<NULL>	Individuals of both sexes diagnosed with moderate or severe obstructive sleep apnea by polysomnography or polygraphy; be between 30 and 70 years old; no history of specific apnea treatment in the last two months; sedentary or insufficiently active according to the International Physical Activity Questionnaire	History of neuromuscular disorders; infectious diseases; immunological diseases; tumors; peripheral vascular diseases; coagulation disorders; liver or kidney disease; severe psychogenic disorders or acute or chronic renal failure; platelet patients; hx of head or neck injury or surgery in the last 3 months; administration of hormones, immunosuppressants, cytotoxins or free radical scavengers; use of medications such as oral corticosteroids, central nervous system depressants, barbiturates and / or muscle relaxants, patients with impaired cognitive impairing the understanding and execution of research procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-4j342n	Acute Effect of Interval and Continuous Training of Moderate Intensity on Cardiometabolic Responses of Type 2 Diabetics Hypertensive subjects	Recruiting	Intervention	2019-09-18	<NULL>	<NULL>	2967	Acute Effect of Interval and Continuous Aerobic Training of Moderate Intensity on Blood Glucose, Blood Pressure and Flow-Mediated Dilatation of Type 2 Diabetics Hypertensive subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4j342n	<NULL>	Subjects of both sexes; aged 40-60 years; with type 2 diabetes; with hypertension on stage one or two; with no history of regular exercise for at least six months; with sedentary habits	Subjects with cardiovascular disease; individuals with comorbidities associated with diabetes; with any other chronic disease; subjects with functional limitations; with joint problems; smokers; who use insulin; who use vasodilatory medications; women who have not reached menopause; women doing hormone replacement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-5qkchbv	Acute Effect of Locomotion Training with Visual and Auditory Stimuli on kinematic parameters and locomotion confidence in individuals after Stroke: a randomized clinical trial	Recruiting	Intervention	2026-01-19	<NULL>	<NULL>	8771	Acute effect of biofeedback Gait Training on kinematic parameters and walking confidence in individuals after Stroke: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-10	Faculdade de Fisioterapia	<NULL>	<NULL>	<NULL>	Both genders; who suffered a stroke less than 6 months ago (acute); who present residual motor impairments in at least one lower limb; aged 18 years or older; ambulate independently without the need for assistive devices; achieve the minimum score on the six-item cognitive impairment test (6CIT-P) for cognitive function assessment (which varies according to education level); muscle tone in the affected lower limb with a score between 1 and 1+ on the Ashworth scale	Patients who do not demonstrate safety to walk on the treadmill even after 3 familiarization sessions; those who experience adverse events during the intervention such as severe pain, falls, excessive fatigue, or any hemodynamic instability that contraindicates the continuation of the protocol; participants should not have bilateral motor impairment, nor an associated diagnosis of other neurological diseases (such as Parkinson&apos;s disease or multiple sclerosis), nor severe hearing or visual impairments that hinder the reception of biofeedback stimuli; those currently using botulinum toxin in the lower limbs or with decompensated cardiovascular disorders; during follow-up, participation will be considered irregular if the volunteer attends less than 70% of the sessions scheduled in the protocol. In this situation, the participant will be removed from the study, as low attendance could compromise both the effectiveness of the treatment and the reliability of the results	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-5gkdn2r	Acute effect of low-intensity aerobic exercise with blood flow restriction on motor learning	Recruitment completed	Intervention	2023-11-17	<NULL>	<NULL>	6585	Aerobic exercise and motor learning: Does blood flow restriction induce increased effects?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-10	Universidade Estadual do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-5gkdn2r	<NULL>	Be aged between 18 and 50 years old. Both genders. Be right-handed. Be a higher education student, regardless of semester. Have sufficient neuromotor and cognitive conditions to understand and perform the proposed tasks. Have a medical report allowing the practice of physical activity, especially those related to blood flow restriction exercise protocol. Use corrective lenses in case the participant has visual acuity. Sign the Informed Consent Form	Have cardiovascular diseases, a history of thrombosis, respiratory diseases, diabetes mellitus, obesity, or any other medical condition that would prevent the execution of the proposed activities, especially those related to the blood flow restriction exercise protocol. Do not have a medical report indicating any risk in engaging in physical activity, especially related to the blood flow restriction exercise protocol. Have osteoarticular impairments that prevent the execution of the task or may be aggravated due to the proposed practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-9mq5r8k	Acute effect of mobilization with movement in low back pain patients	Recruiting	Intervention	2021-05-10	<NULL>	<NULL>	4632	Acute effect of mobilization with movement in low back pain patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Universidade do Vale do Sapucaí	Universidade do Vale do Sapucaí	https://ensaiosclinicos.gov.br/rg/RBR-9mq5r8k	<NULL>	Experimental Group 1: volunteers of both genders; aged between 18 and 60 years old; who present with episodes of pain in the lower back and lower limbs; with medical clearance for the practice of the intervention. Experimental Group 2: volunteers of both genders; aged between 18 and 60 years old; who present with episodes of pain in the lower back and lower limbs; with medical clearance for the practice of the intervention.	Volunteers without low back pain will be excluded; cognitive difficulty regarding assessment and intervention instruments; infectious diseases; disabling diseases in the upper and lower limbs; carriers of myopathies; diseases with recognized alteration of collagen; carriers of neurological diseases; for personal reasons do not want to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-6t544q7	Acute effect of Myofascial Release Techniques of the legs and feet, on mobility and high of the vertical jump tests in active individuals	Recruitment completed	Intervention	2023-08-11	<NULL>	<NULL>	6333	Acute effect of Osteopathic Techniques for releasing the deep and superficial plantar fascia and the gastrocnemius on mobility and performance in vertical Jump Tests in physically active individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Colégio Brasileiro de Osteopatia	Colégio Brasileiro de Osteopatia	https://ensaiosclinicos.gov.br/rg/RBR-6t544q7	<NULL>	Volunteers of both genders; age between 23 and 40 years; physically active; exercise 3 times a week or more; practice resistance exercises for more than 6 months	Volunteers who are contraindicated for manual therapy. With tumors, fractures, arthritis rheumatoid, severe vascular condition), who had surgery in the lower limbs and are incapable to jump	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-5qp73j	Acute effect of Physiotherapy on patient&apos;s blood cells after Fracture Fixation Surgery	Recruiting	Intervention	2019-10-29	<NULL>	<NULL>	3143	Acute effect of Physiotherapy on Cell Markers of Postoperative Fracture patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-14	Universidade Feevale	Fundação de Saúde Pública de Novo Hamburgo	https://ensaiosclinicos.gov.br/rg/RBR-5qp73j	<NULL>	Age between 18 and 59 years old; both sexes; first postoperative day of lower limb fracture fixation; Clinically stable; Making use of anti-inflammatory medication	Ribs fractures and / or upper limbs and / or preventing the intervention; diagnosis of rhabdomyolysis; limitations that prevent exercises performance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-33dz538	Acute effect of portable device Massage on Muscle Fatigue, Muscle Pain, and Physical Performance in active subjects: a cross-over randomized clinical trial	Recruitment completed	Intervention	2024-03-25	<NULL>	<NULL>	6893	Acute effect of Percussive Massage on Muscle Fatigue, Muscle Pain and Physical Performance in active subjects: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-33dz538	<NULL>	Active participants aged 18 to 40; of both sexes; with at least 6 months of experience in leg extension exercises	Participants self-reporting muscular or skeletal pain or injury in the hip and knee at the time of the initial assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-2qfvyfv	Acute effect of pre-workout supplements on the performance of amateur athletes	Recruitment completed	Intervention	2020-12-07	<NULL>	<NULL>	4400	Changes in performance, body composition and biochemical parameters of young adults after acute and chronic supplementation with pre-training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-18	Fundação Universidade Estadual do Piauí	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2qfvyfv	<NULL>	Healthy young adult man; age between 18 and 35 years old; able to run 10 km in less than 60 minutes.	Presence of cardiovascular or joint diseases; use of medication for continuous use; regular consumption of food supplement or stimulants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-7zq9d89	Acute effect of the Sit-Stand Table on Nervous System Control of Heart and Arteries of healthy people: crossover, randomized and controlled clinical trial	Recruiting	Intervention	2023-06-04	<NULL>	<NULL>	6132	Acute effect of the Sit-Stand Table on Cardiovascular Autonomic Control in normal-weight individuals: crossover, randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-7zq9d89	<NULL>	Be between 23 and 45 years of age; work for a period equal to or greater than 4 hours in a seated position and use the computer as their main work tool; not report suffering of chronic health problems; being a non-smoker for more than 1 year; for women, being in the follicular phase, in the period between the seventh and tenth day of the menstrual cycle, i.e., between the end of menstruation and mid-cycle; agreeing to participate in the study; and, not having symptoms of coronavirus disease 2019 (COVID-19).	Having a physical condition that prevents them from performing postural changes from sitting to standing or standing for more than 20 minutes; having signs and symptoms of pregnancy or being in gestational period; report having cardiovascular diseases [heart failure, coronary artery disease, arterial hypertension, changes in heart rhythm (atrial fibrillation, ventricular arrhythmia, ventricular tachycardia), valvular heart disease, acute myocardial infarction]; having the following conditions: type 1 and 2 diabetes, cardiac pacemaker, personal or family history of venous thrombosis or pulmonary embolism, presence of stroke sequelae; being an alcoholic, user of tobacco, nicotine products and illicit drugs; regularly use immunosuppressive drugs, corticosteroids, vasodilators, anxiolytics, beta-blockers and insulin; women with regular use of contraceptives or hormone replacement; and, menopausal women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-7nnrdv	Acute effect of the squat exercise on the guided bar performed with different training strategies on the risk of falling in elderly women with no experience in resistance training	Recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3575	Acute effect of different strength exercise configurations on functional capacity and risk of falling in untrained elderly women: a randomized crossover study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7nnrdv	<NULL>	women; age between 60 and 75 years; postmenopausal women with an interval greater than or equal to 12 months in relation to the last menstruation; have not undergone hormone therapy until 3 months before the study; not having a heart transplant; using a pacemaker or having arrhythmias; present a body mass index (BMI) between 25 and 30 kg / m2; be classified as “Active” according to the international physical activity questionnaire (IPAQ) long version; functionally independent (greater than 103 points in the general score) according to the Functional Independence Measure - MIF and not being strength training practitioners; not having any medical contraindication for physical exercise (eg, fractures, surgeries and / or osteo-myo-articular injuries); non-diabetic or with controlled diabetes; normotensive or controlled hypertension less than 150/100 mmHg; 10) without infectious diseases; have the cognitive performance evaluated positively (illiterate between 20 and 24 points; 1 to 4 years of schooling between 25 and 26 points; from 5 years of schooling between 26 and 27 points; from 9 and 11 years of schooling with 28 points; and greater than or equal to 11 years of schooling with greater than or equal to 29 points) through the Mini Mental State Examination - MEEM; no vestibular problems and complaints of dizziness according to the Dizziness Handicap Inventory - DHI questionnaire.	do not obtain frequency of 100% of the proposed visits; reporting consumption of dietary supplements; alcoholic beverages 24 hours before the scheduled visit; diseases that make it impossible for them to continue in the training program (eg, musculoskeletal or cardiovascular aggravation); and obtain inadequate completion of any of the tests, as well as the experimental sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-5q4m7t	Acute effect of treadmill exercise on blood viscosity and IGF-1 protein in Alzheimer&apos;s disease	Data analysis completed	Intervention	2020-03-27	<NULL>	<NULL>	3680	Acute effect of aerobic exercise on blood viscosity and IGF-1 in Alzheimer&apos;s disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-13	Unesp - Universidade estadual paulista	Ufabc - Universidade federal do ABC	https://ensaiosclinicos.gov.br/rg/RBR-5q4m7t	<NULL>	Older adults over 60 years of age, of both sexes; Older adults with clinical diagnosis of Alzheimer&apos;s disease, Level of mild dementia severity according to the Clinical Dementia Rating Score (CDR) (MORRIS, 1993; MONTAÑO; RAMOS, 2005). The adoption of this criterion is due to the nature of the specific procedures of the proposed physical exercise intervention protocol, which requires a certain level of understanding of the activities by the elderly. Availability to participate in the activities proposed by the researcher; Agree and sign the Free and Informed Consent Term based on Resolution 466/12 of the National Health Council.	Older adults with coronarian disease, cardiac arrhythmia, non-controlled hypertension and angina symptons or any restriction to physical activity; Older adults with visual, hearing, vertiginous syndrome non-corrected impairment impairment or another limitation that prejudices locomotion; Older adults with another neuropsychiatric condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-2n932c	Acute effect of Whole Body Vibration in patients with Rheumatoid Arthritis	Recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2497	Acute effect of the Whole Body Vibration in the push up modified position in physical and functional parameters in upper limbs of patients with Rheumatoid Arthritis	<NULL>	2, single-arm-study, single-blind	2	<NULL>	<NULL>	<NULL>	2018-02-20	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Fundação de Amparo à Pesquisa de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2n932c	<NULL>	Women aged 40-60 years, according to the American College of Rheumatology criteria for RA, with at least 6 months of evolution. Some degree of disease activity should be present and pharmacological treatment should be stable for at least 1 month prior to the study, including analgesics, non-steroidal anti-inflammatory drugs, glucocorticoids (must be equal to or less than 15 mg / day prednisone or equivalent). The activity of the disease will be considered with the presence of signs and symptoms that, in the judgment of the physician, would require alteration of the therapy or progression to the more aggressive treatment regimen. Patients should be able to respond to the Health Assessment Questionnaire (HAQ) and global assessment of the patient&apos;s treatment and visual analog pain scale (VAS).	Patients who have sensory disorders, active infection, alcoholism or drug abuse, are pregnant or breastfeeding, using anticoagulants or other complementary treatment, presence of any concomitant illness that will prevent them from attending the sessions, presence of any another rheumatic disease, associated or not, which could interfere with the assessment of efficacy and safety and presence of serious complications of RA or that the disease is advanced. During the study, patients will maintain prior drug therapy without adjustments. Participants will be able to use analgesic during the study period if they really feel the need. However, it will be considered as data loss or a new date will be scheduled for data collection. Intra-articular infiltrations or other procedures, such as physical therapy or corrective surgeries, will not be accepted. and will not be able to use analgesics for pain. Intra-articular infiltrations or other procedures, such as physical therapy or corrective surgeries, will not be accepted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-3gzsnn	Acute effect of Whole-body electrostimulation on cardiovascular and oxygen responses during exercise in obese individuals	Data analysis completed	Intervention	2020-09-20	<NULL>	<NULL>	4265	Acute effect oh Whole-body electromyostimulation on autonomic heart modulation and capacity cardiopulmonary in individuals with obesity	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3gzsnn	<NULL>	Male volunteers; aged between 18 and 40 years; body mass index (BMI) higher than 30 kg/m² were considered obese; BMI between 18.5 to 24.9 kg/m² were considered eutrophic	Smoking volunteers; users of illicit drugs that influence the autonomic nervous system; hypertensive; diabetics; or other cardiorespiratory diseases; history of alcoholism; medication users who could alter the autonomic nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-9x3d52	Acute effect on the strength of exercise with different loads and muscle mass recruited in cardiovascular variables: blood pressure, heart rate, rate-pressure product and post-exercise hypotension in healthy women and active	Recruitment completed	Intervention	2016-03-16	<NULL>	<NULL>	756	Acute effect of resistance exercise of different intensities and recruited muscle mass in hemodynamic variables: blood pressure, heart rate, rate-pressure product and post-exercise hypotension in active normotensive women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Instituto de Educação Física e Esportes - Universidade Federal do Ceará	Instituto de Educação Física e Esportes - Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9x3d52	<NULL>	Healthy normotensive women; aged between 18 and 30 years; with minimum experience of 8 months in resistance training; has no personal history of cardiovascular disease; in continuous training in ER of at least four months.	Known cardiovascular disease; arterial hypertension; smoking; diagnosed osteoporosis; musculoskeletal problems that prevent or restrict the realization of the leg-press exercise 45; make use of any medication or drugs that stimulate the cardiovascular system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-1082sd5r	Acute effects of breaking sedentary behavior with isometric squat on blood pressure, cardiac autonomic modulation, and cognitive function in hypertensive individuals during the workday	Recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8579	Acute effects of breaking sedentary behavior with isometric squatting on blood pressure, cardiac autonomic modulation, and cognitive function in hypertensive individuals during the workday: a randomized crossover trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-28	Universidade Federal Rural de Pernambuco	<NULL>	<NULL>	<NULL>	Adults with hypertension; aged 30 to 59 years; perform administrative work while seated for more than 6 hours per day; no musculoskeletal problems in the lower limbs that prevent squatting or standing; no cardiac or cerebrovascular diseases; not using insulin; perform occupational activities in a workplace with adequate physical infrastructure; wear flat shoes suitable for performing the interventions	Individuals who do not complete the protocol of the break or control sessions; transferred to another position or function that changes the characteristics of the occupational activity; choose not to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-10g25ty6	Acute effects of Cognitive Tasks associated with aerobic physical exercise on a stationary bike on Brain Derived Neurotrofic Factor (BDNF) factor Blood Levels and on the cognitive performance in Elderly Participants	Recruiting	Intervention	2025-05-12	<NULL>	<NULL>	7998	Acute effects of the Dual Cognitive Task associated with Aerobic Physical Exercise on BDNF factor serum levels and Cognitive Performance in older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Estadual De Londrina - UEL	Departamento De Educação Física Da Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-10g25ty6	<NULL>	60 or over. Both sexes. Physically independent. Normal cognitive status or with mild cognitive impairment. Not included in physical exercise programs	Use of medications antidepressants and beta blockers. Decompensated illness as  hypertension, arrhythmias, or other physical and/or psychological conditions that prevent them from participating in assessments and interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-24px5hf	Acute effects of Dry Needling applied to muscles of recreational street runners: a randomized clinical trial	Recruiting	Intervention	2025-05-29	<NULL>	<NULL>	8027	Acute effects of Dry Needling applied to trigger points in the gastrocnemius muscles of recreational street runners: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-28	Universidade do Estado do Pará	Secretaria Municipal de Esporte e Lazer de Castanhal	https://ensaiosclinicos.gov.br/rg/RBR-24px5hf	<NULL>	Adults aged 18 to 35 years old; of both sexes; who practice street running recreationally, twice a week, run at least 15 km per week; with a practice time of at least 3 months, in a non-professional manner without receiving remuneration or material incentives and/or sponsorships; who agree to participate in the research and sign the TCLE; have 1 to 3 latent tension points or myofascial triggers in each gastrocnemius which	Runners who undergo professional rehabilitation monitoring or with a physiotherapist during the research data collection; have some acute or chronic persistent Osteomyoarticular Injury in the last 3 months; have serious health changes or bleeding disorders; fibromyalgia; pregnant women; autoimmune disease; iron deficiency; hypothyroidism; use lower limb prosthesis; people with fear of needles; have performed Dry Needling or acupuncture 4 weeks before; using anticoagulants; analgesic medications in the last 24 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-102jnmyx	Acute Effects of Exercise Using One Joint or More Joints on Glycemia in Patients with Type 2 Diabetes	Recruiting	Intervention	2022-09-14	<NULL>	<NULL>	5609	Acute Effects of Monoarticular versus Multiarticular Strength Training on Glycemia in Individuals with Type 2 Diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-102jnmyx	<NULL>	Acceptance to participate in the research by signing the Free and Informed Consent Form; having a diagnosis of Type 2 Diabetes, confirmed by a blood test or medication use; minimum age of 18 years; not practicing physical exercises systematically at least twice a week; controlled glycemia using medication and having a glycemic range of control value between 100 and 300 mg/dl to perform the exercises safely.	Presence of severe autonomic neuropathy, severe peripheral neuropathy, or history of foot injuries; proliferative diabetic retinopathy, severe non-proliferative diabetic retinopathy; decompensated heart failure; peripheral amputations; muscular or joint impairment that prevents the performance of the proposed exercises and impossibility of detachment to carry out the evaluation and/or training visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-8v5z7r2	Acute effects of manual therapy on pain and functional performance in jiu-jitsu practitioners with Patellofemoral Pain Syndrome: a randomized, triple-blind crossover clinical trial	Recruiting	Intervention	2025-08-08	<NULL>	<NULL>	8192	Acute effects of Instrument-Assisted Soft Tissue Mobilization and Joint Mobilization on pain and functional performance in jiu-jitsu practitioners with Patellofemoral Pain Syndrome: a randomized, triple-blind crossover clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-31	Universidade do Estado do Pará - Centro de Ciências Biológicas e da Saúde - Campus II	Universidade do Estado do Pará - Centro de Ciências Biológicas e da Saúde - Campus II	https://ensaiosclinicos.gov.br/rg/RBR-8v5z7r2	<NULL>	Jiu-jitsu practitioners; of both sexes; aged between 18 and 45 years; with a minimum of 2 years of continuous practice of the modality on a regular basis; who present with recurrent anterior knee pain in the last 4 weeks, of atraumatic origin; present pain in two or more situations, including running, jumping, squatting, kneeling, climbing and descending stairs, resisted knee extension and patellar palpation; agree to participate in the research voluntarily through the Consent Form	People who do not practice the sport regularly; who present any clinical condition that is a contraindication to performing physical exercise and the techniques applied; history or suspicion of tendinopathies, dislocations and other knee injuries; who have undergone surgical procedures; who are undergoing other therapeutic interventions, use of ergogenic resources during the data collection period or use continuous medication; who are pregnant; and anyone who does not accept to participate in the research voluntarily through the Free and Informed Consent Form will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-7pxmfjc	Acute effects of motor rehabilitation in stroke survivors through resistance training and neuromodulation	Not yet recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7907	Motor rehabilitation in stroke survivors with severe functional impairments through unilateral eccentric training combined with cortical neuromodulation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Instituto de Física Gleb Whatagin	Instituto de Física Gleb Whatagin	https://ensaiosclinicos.gov.br/rg/RBR-7pxmfjc	<NULL>	Patients who suffered a stroke (type 1); patients who have severe hemeparesis as a consequence of the stroke; both female and male patients; patients above 18 years old	Patients who have any type of metal inside their body (pins, pacemakers, metal prostheses, revolver bullets); patients who have any musculoskeletal injury on the affected or unaffected limbs; patients who had previous conditions such as seizures, head trauma, hearing problems and cochlear impalants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-5gxdv9y	Acute effects of Passiflora incarnata on endothelial function, blood pressure, and heart rate in healthy adults	Not yet recruiting	Intervention	2026-02-05	<NULL>	<NULL>	8829	Acute effect of Passiflora incarnata on endothelial and hemodynamic function in healthy adults: a randomized, double-blind, crossover, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Adults; of both sexes; aged between 18 and 40 years, will be included	Participants will be excluded if they have a history of chronic diseases; are smokers; use medications on a continuous basis that may influence vascular responses; have a known allergy to Passiflora incarnata or to any component of the formulation; use drugs with sedative effects, such as pentobarbital and hexobarbital; anticoagulants such as warfarin; or monoamine oxidase inhibitors (MAOIs), including isocarboxazid, phenelzine, and tranylcypromine, due to their potential to interfere with the hemodynamic responses assessed and to increase the risks involved in the study. In addition, participants who regularly use antioxidant supplements or nitrates, or who have consumed polyphenol-rich foods (e.g., beetroot, chocolate, green tea, citrus fruits) within the 24 hours preceding the experiment will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-7nj9w4	Acute effects of photobiomodulation on respiratory variables and functional capacity in smokers and ex-smokers	Recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4037	Acute effects of photobiomodulation on respiratory variables and functional capacity in smokers and ex-smokers: randomized clinical trial, triple-blind and controlled placebo	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-14	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7nj9w4	<NULL>	For study 1 volunteers aged over 18 years will be included; smokers aged 1-10 years and smokers aged 11-20 years. For study 2 volunteers aged over 18 were included; ex-smokers for a period of at least 12 months. All volunteers must be clinically stable; do not show dyspnea symptoms on small and medium efforts.	"Alcoholic volunteers who have a cardiac pacemaker implant, coexisting neurological disease and have presented
any lung disease diagnosed, or use of corticosteroids in the last 4 weeks. Volunteers who practice
regular physical exercise, defined as participation in pulmonary rehabilitation programs or structured physical training (3 times per
week) in the last three months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-6vgmtb	Acute effects of photobiomodulation therapy in type 2 Diabetes Mellitus	Recruitment completed	Intervention	2018-10-08	<NULL>	<NULL>	4998	Effects of photobiomodulation therapy on metabolic, hemodynamic and ventilatory variables in type 2 Diabetes Mellitus	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de São Carlos	Coordenação de Aperfeiçoamento de pessoal de nível superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-6vgmtb	<NULL>	Sedentary volunteers; male gender; with Type 2 Diabetes mellitus; non smokers; non-alcoholic; age between 40 and 64 years; body mass index less than 35 kg / m²; with an ankle-brachial index within normal values	Volunteers with autonomic neuropathies; with electrocardiographic alterations such as ST-segment elevation, ischemia, branch block, arrhythmias or angina induced by physical exertion; and others cardiovascular, respiratory, neurological or osteomioarticular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-8fffvv	Acute effects of Phototherapy on the Functional Capacity of patients Admitted to Hospital   Intensive Care Unit	Recruitment completed	Intervention	2019-11-07	<NULL>	<NULL>	3172	Acute effects of Photobiomodulation by Leds (light-emitting diodes) on the Functional Capacity of patients Admitted to Hospital   Intensive Care Unit	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Brasil	Associação Piauense de combate ao câncer/ hospital São Marcos	https://ensaiosclinicos.gov.br/rg/RBR-8fffvv	<NULL>	Adults (higher than 18 years old) hospitalized in  intensive care unit (ICU) of a philanthropic hospital due to postoperative cardiac surgery or acute respiratory failure	Patients with plegia, paresis, amputation or congenital deformities in at least one limb, and patients with data insufficiently described in their hospital chart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-9yrfyfq	Acute Effects of Respiratory and Resistance Training with Blood Flow Restriction on respiratory, hemodynamic variables and peripheral muscle strength in subjects with COPD	Recruiting	Intervention	2023-11-21	<NULL>	<NULL>	6594	Acute Effects of Respiratory and Resistance Training with Blood Flow Restriction on respiratory, hemodynamic variables and peripheral muscle strength in subjects with COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-19	Centro de Ciências da Saúde - Universidade Federal da Paraíba	Centro de Ciências da Saúde - Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9yrfyfq	<NULL>	Diagnosis of mild, moderate or severe Chronic Obstructive Pulmonary Disease (COPD), that is, presenting a Forced Expiratory Volume in the first second (FEV₁) after bronchodilator between 30% and ≥ 80% of the predicted value; age over 60; both genders; absence of locomotor or neurological comorbidities that prevent the performance of tests and exercises; no exacerbation of symptoms and stable pharmacological regimen for at least two months before the start of training; who voluntarily accept to participate in the research by signing the Free and Informed Consent Form (TCLE)	Present during the experiment any cardiovascular and musculoskeletal aggravating factors that prevent treatment from being carried out; no carry out at least 85% of treatment sessions, or; withdraw from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-4pc22n	Acute effects of smoker&apos;s lung defense mechanism	Data analysis completed	Intervention	2014-08-18	<NULL>	<NULL>	327	Acute response of smoker&apos;s mucociliary clearance exposed to moderate aerobic exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-21	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; - Faculdade de Ciências e Tecnologia	"Departamento de Fisioterapia da Universidade Estadual Paulista ""Júlio de Mesquita Filho"" - Faculdade de Ciências e Tecnologia"	https://ensaiosclinicos.gov.br/rg/RBR-4pc22n	<NULL>	Subjects between 30 and 50 years old, both genders, with normal lung function attested by spirometry and absence of illnesses that interfere with exercise performance or autonomic modulation (eg, cerebrovascular, cardiac, orthopedic, rheumatic or metabolic disease, diabetes, alcoholism).	Not comprehension or non-cooperation on the procedures and methods of research; non-attendance at one of the days of the experimental protocol; subjects with lung disease diagnosed, history of surgery or nasal trauma, nasal septal deviation or inflammation of the upper airways observed in clinical evaluation during the interview and experimental protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-2mqbwbd	Acute effects of the application of the foam roller on dorsiflexion and squat performance in extreme conditioning program practitioners: randomized clinical trials.	Terminated	Intervention	2022-07-19	<NULL>	<NULL>	5495	Acute effects of the application of the foam roller on dorsiflexion and squat performance in extreme conditioning program practitioners: randomized clinical trials.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade do Estado de Minas Gerais	Luana Rocha Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2mqbwbd	<NULL>	Men and women between 18 and 45 years old practicing an extreme conditioning program for more than 4 months.	Feeling pain when performing the tests; pregnancy; history of cardiac and/or neurological problems; history of previous injury or surgery in the lower limbs; they have pathologies that affect balance, such as labyrinthitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-7mzt6x	Acute effects of thoraco-lumbar Fascial Mobilization on tissue displacement, pain and function of individuals with Chronic Low Back Pain	Recruitment completed	Intervention	2020-01-27	<NULL>	<NULL>	3405	Acute effects of thoraco-lumbar Fascial Mobilization on tissue displacement, pain and function of individuals with Chronic Low Back Pain: crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7mzt6x	<NULL>	Young men and women over 18 years of age, with lower back pain for more than 3 months, with at least grade 4 pain on visual analogue scale analysis.	People with a history of previous or scheduled surgeries in the trunk or limb region; know or suspect severe fractures or pathology like tumor, inflammation or infection, rheumatologic disorder, aortic aneurysm, radiculopathy or neupathy with or without spinal cord stenosis with proven MRI, structural deformity of the spine, spondyloarthropathy, equine tail syndrome. limitation of significant movement or comorbidity, disabling pain and physical disability that makes the analysis impossible; use of analgesic or anti-inflammatory 48h before the tests; neurological or psychiatric disorder; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-62y3h7	Acute impairment of renal function in COVID-19: study on incidence, risk factors and mortality	Recruiting	Observational	2020-05-18	<NULL>	<NULL>	3844	Acute Kidney Injury in Infectious Coronavirus Disease: a study on incidence, risk factors and mortality	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-62y3h7	<NULL>	suspected diagnosis of COVID-19	negative test for COVID-19; patients without diuresis control or at least two creatinine tests during hospitalization; pregnant women; age under 18; patients with advanced CKD (Cl Cr &lt;30 ml / min; kidney transplant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-9fz4tys	Acute influence of photobiomodulation on muscle power and cardiovascular variables in physically active subjects undergoing submaximal exercise test	Recruitment completed	Intervention	2023-08-24	<NULL>	<NULL>	6382	Acute influence of intravascular laser irradiation of blood (ILIB) on muscle power and cardiovascular variables in physically active subjects undergoing submaximal exercise test	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-07	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9fz4tys	<NULL>	Have to be a university student aged between 18 and 40 years old; must be practicing regular physical exercise for at least three months; performing moderate physical activity for 150 to 300 minutes or 75 to 150 minutes of intense physical activity per week	If is a user of a drug or substance that has a known effect on cardiovascular aspects; If has a musculoskeletal or cardiovascular disease; If uses alcohol, tobacco, or caffeine for 12 hours before the assessment steps; If had practice physical activity in the 24 hours before the initial and final assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-6pmfz8	Acute Lymphoblastic Leukemia treatment protocol for children and adolescent	Recruiting	Intervention	2016-03-11	<NULL>	<NULL>	746	Acute Lymphoblastic Leukemia treatment protocol for children and adolescent GBTLI ALL-2009	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2010-01-01	Sociedade Brasileira de Oncologia Pediátrica (SOBOPE)	Centro Infantil Boldrini (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-6pmfz8	<NULL>	"Will be eligible for this study all patients aged &lt; 18 years (up to 17.99 years ) diagnosed with previously untreated ALL, with emphasis on no steroid use.
The requisites for proper leukemia diagnostic profile are: cytomorphological analysis, cytochemistry, immunephenotyping spinal fluid profile, cytogenetics and molecular biology
All patients and their legal representatives should be informed about the investigative nature of this study and must sign and provide free and informed consent in accordance with institutional and federal recommendations."	"Without Informed Consent Term.
ALL patient aged &gt; 18 years.
Prior use of corticosteroids.
Not confirmed the ALL diagnosis, after Central review."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-8ypr4kj	Acute neuromuscular fatigue responses to russian current in paralympic powerlifting athletes	Data analysis completed	Intervention	2026-01-05	<NULL>	<NULL>	8695	Analysis of training based on biochemical, hormonal, immunological, blood, hemodynamic, muscle architecture, and neuromuscular indicators in Paralympic powerlifting	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Departamento de Educação Física da Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Minimum of 18 months of experience in the sport; participation in at least one official competition of the Brazilian Paralympic Committee; ranking among the top 10 in their respective body weight categories	Volunteer with pain and/or injury; intolerance to electrostimulation; use of analgesics, tranquilizers, antidepressants or any centrally acting medication	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-2b2prdz	Acute responses of the Cardiovascular System in elderly people with high blood pressure submitted Plyometric Exercise	Recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6964	Acute responses of Systemic Blood Pressure and Cardiac Autonomic Modulation in hypertensive elderly people subjecting to Plyometric Exercise	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Instituto Multidisciplinar de Reabilitação e Saúde - Universidade Federal da Bahia - UFBA	Faculdade de Educação FACED - Universidade Federal da Bahia UFBA	https://ensaiosclinicos.gov.br/rg/RBR-2b2prdz	<NULL>	Women; minimum age 60 years old; diagnosis of arterial hypertension; use antihypertensive medication with a maintained dose for the last 4 months;  do not present secondary arterial hypertension and/or target organ damage; do not use medications that directly affect cardiac autonomic regulation (e.g. beta blockers and non-dihydropyridine calcium channel inhibitors); do not present other cardiovascular diseases; do not present class 2 obesity or higher; do not have diabetes with complications or use insulin;  do not present orthopedic damage that hinders the practice of resistance training	Resting systolic blood pressure above 160 mmHg and/or Diastolic Blood Pressure above 105 mmHg; missing collection days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-98wb56	Adaptation of the Denture after the installation	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	3368	Influence of the Height of the Mandibular Ridge on the functional adaptation with Dentures	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-07	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-98wb56	<NULL>	Adults ndividuals; both genders; bimaxillary edentulous; aged 40 to 90 years, of both genders; users conventional complete dentures; requiring replacement of dentures; receptives; mentally agiles; good understanding of speaking Portuguese; mandibular ridges with normal or resorbed volume; normal amount and quality of saliva	Debilitating systemic diseases; pathological changes in the oral tissues; neuromuscular impairment; temporomandibular disorders; use of a cardiac pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-68qv6wf	Adaptation, usability and initial results of a mindfulness program to support people in the search for meaning in life in a study with comparison groups	Not yet recruiting	Intervention	2025-06-25	<NULL>	<NULL>	8065	Adaptation, feasibility, and preliminary effectiveness of a Mindfulness-based program (Mindfulness-based health promotion - mbhp) for the search for meaning in life: a randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-68qv6wf	<NULL>	General population aged 18 years or older (based on the Mindfulness-Based Health Promotion - MBHP protocol)	a) Participants in the acute phase of depression; bipolar disorder; psychotic disorders, especially those with severe symptoms; b) Participants at risk of or with a history of dissociation, post-traumatic stress disorder, personality disorder, epilepsy, etc.; c) Participants using medications that cause cognitive impairment; d) Those with evident cognitive impairment; e) Those without access to high-speed internet for online videoconferencing (computer or smartphone); f) Those who are not available to attend 8 online sessions, each lasting 2 hours, and are unable to commit to completing the prescribed home practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-6ckggn	Adapted Functional Training and Pilates Method in Individuals with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2019-11-21	<NULL>	<NULL>	4106	The Impact of Adapted Functional Training and the Solo Pilates Method on Motor and Non-Motor Symptoms of Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6ckggn	<NULL>	Inclusion criteria are defined as, participants with a clinical diagnosis of PD following the UK brain bank criteria (HUGHES et al., 1992); both sexes; aged 50 years or over; with stable doses at; at least two weeks; no change in medication; without any functional training or solo pilates for at least three months.	Exclusion criteria were, participants who did not reach the MMSE cut-off point (considering educational level) (BERTOLUCCI et al., 1994); classified in stage 5 PD (HOEHN; YAHR, 1967); who performed practice of any physical exercises to avoid confusion bias in the intervention; who did not complete all stages of the study; were not present in 75% of the prescribed classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-3jhv37y	Adapted strength and balance training for institutionalized and non-institutionalized elderly: effects on strength, performance, and balance	Recruiting	Intervention	2025-01-27	<NULL>	<NULL>	7686	Effects of a strength and balance training protocol in different groups of elderly people	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Pontifícia Universidade Católica do Parana - PUCPR	Pontifícia Universidade Católica do Parana - PUCPR	https://ensaiosclinicos.gov.br/rg/RBR-3jhv37y	<NULL>	Elderly individuals over 60 years old; of both sexes; who have not participated in strength and balance exercise programs for at least six months; must be physically capable of performing physical tests; and have medical clearance to participate in exercises	Elderly individuals who are unable to perform the physical tests; engage in any type of strength and balance exercises not included in the present study; or report any injury during the training period will be excluded; those who fail to attend at least 75% of the total training sessions will be considered sample loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-2j2zw3h	Adaptive evaluation of treatments for arboviruses (Adapta-Arbo): A clinical study to compare the dose-response relationship between Molnupiravir and placebo in patients with Chikungunya and Dengue	Recruiting	Intervention	2024-10-22	<NULL>	<NULL>	7446	Adaptive evaluation of arbovirus treatments (Adapta-Arbo): A randomized, adaptive, double placebo-controlled trial to evaluate the pharmacodynamics of Molnupiravir in early symptomatic Chikungunya and Dengue infections	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-03-19	Universidade Federal de Minas Gerais	Instituto Nacional de Ciência e Tecnologia Em Dengue	https://ensaiosclinicos.gov.br/rg/RBR-2j2zw3h	<NULL>	A patient who understands the procedures, is willing and able to give informed consent for full participation in the study. The participant must be an adult between 18 and 65 years old at the time of consente and male or female. The participant has to present symptoms compatible with the diagnosis of an acute arboviral infection, including fever, myalgia, arthralgia or arthritis, headache, conjuntivitis, which began no later than 60 hours before the time of inclusion. The participant agrees and is able to adhere to all study procedures, including providing contact information and is available for follow up visits	Patients taking any chronic medication that may interact with Molnupiravir or have antiviral activity in the opinion of the study&apos;s principal investigator. Patients with any disease/chronic condition with significant comorbidity in the opinion of the study&apos;s principal investigator. Presenting clinically relevant laboratory abnormalities. Contraindication or hypersensitivity to molnupiravir. Current participation in another drug clinical trial. Evidence of another infectious condition that explains the current symptoms. And, for women, pregnancy, trying to become pregnant, or lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-3h5sc8	Adding expiratory muscle training to breath stacking technique on clinical and functional outcomes in patients with neuromuscular disease	Not yet recruiting	Intervention	2019-09-17	<NULL>	<NULL>	2955	Comparison between maximal insufflation technique associated with expiratory muscle training with maximmum isolated insufflation in patients with neuromuscular diseases	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Escola Superior de Ciências da Saúde	Escola Superior de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3h5sc8	<NULL>	"Diagnosis of neuromuscular disease confirmed by neurologists at the referral center for neuromuscular diseases at Brasília Support Hospital prior to screening for recruitment; age over 16 years; preserved cognition, evidenced by a score greater than or equal to 24 points in the Mini-Mental Status Exam;no barium allergies; without tracheostomy or mechanical ventilation; no diaphragmatic pacemaker
- without associated respiratory disease"	less than 16 years; pregnancy; previous kidney disease or other concomitant diseases; respiratory diseases during the study; hospitalization in intensive care units (ICUs) during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-5kqsnp	Addition of blood flow restriction to passive mobilization reduces hypotrophy rate in Elderly Intensive Care Unit patients: A within patient randomized trial	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	1763	Addition of Peripheral Blood Flow Restriction to Passive Mobilization in muscle atrophy in ICU patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Sociedade Pelotense de Assistência e Cultura(SPAC)	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-5kqsnp	<NULL>	The inclusion criterion was admitted to the ICU sector of two reference hospitals in Belém, from September to October 2017, and to be admitted to the PM protocol, with the following parameters: Pa02 / Fi02&gt; 300, oxygen saturation (BP) &lt;140 bpm, systolic blood pressure (SBP) 90-180 mmHg, arterial blood pressure (BP) &lt;60 bpm, arterial blood pressure (PaO2)&gt; 90% diastolic (DBP) 50-120 mmHg, respiratory rate of up to 30 breaths per minute and absence of uncontrolled ECG arrhythmias.	Death or do not complete intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-4fn5b4p	Additional Effect of Transcutaneous Electrical Stimulation on the Efficacy of Inferior Alveolar Nerve Anesthesia in Irreversible Pulpitis: a randomized placebo-controlled clinical trial	Recruitment completed	Intervention	2023-07-12	<NULL>	<NULL>	6228	Effect of Pain Inhibitory Modulation Techniques on Blockade Analgesic Efficacy Inferior Alveolar Nerve Anesthetic in Irreversible Pulpitis: A clinical trial randomized placebo controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fn5b4p	<NULL>	Clinical diagnosis of unilateral symptomatic irreversible pulpitis in mandibular premolars and molars	Allergy to ketorolac or the anesthetic used; history or presence of uncontrolled systemic diseases; chronic pain; neurological; hormonal; rheumatic; psychiatric disorders; pregnancy; lactation; pacemaker presence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-46hscsv	Adherence and permanence to a physical exercise program by teleorientation in community-dwelling elderly	Recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4984	Adherence and permanence to a physical exercise program by teleorientation in community-dwelling elderly	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-03-12	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-46hscsv	<NULL>	Be 60 years or older; Have access to the internet; Be physically independent; Being sedentary for at least 3 months; Respond to the call made through social networks; Reside in Porto Alegre or metropolitan area; Have availability to participate in the program on the days and times established; Achieve a minimum of 24 points in the mini-mental (in the case of less than 4 years of schooling, the cut-off point changes to 17).	Have physical limitations that make it impossible to perform the proposed exercises; Chronic uncontrolled diseases; Disabling pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-4t46ry	Adherence to DASH dietary pattern and this effect on postpartum weight retention, at primary health care, in Manguinhos - Rio de Janeiro, RJ	Recruitment completed	Intervention	2017-01-02	<NULL>	<NULL>	1664	Proposal of prenatal nutritional assistance in primary health care, at Manguinhos	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-08	Fundação Oswaldo Cruz	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4t46ry	<NULL>	Women; in the period 06-09 months postpartum; who have any weight retention; &gt;18 years old; single fetus pregnancy; infant alive; without chronic diseases diagnosis (except obesity).	Women with chronic diseases (except obesity); in use of medicine that affects weight; who have eating disorders history; have had bariatric surgery; present an allergic manifestation to the diet; get pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-7xk5nr	Adherence to Drug Treatment in Patients with Chronic Pain: A Clinical Trial on the Use of Tablet Organizing Box	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2026	Drug Adherence of Patients with Chronic Pain: a Clinical Trial on the Use of Pill Box	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Departamento de Anestesiologia	"Universidade Estadual Paulista ""Julio de Mesquita Filho"" Faculdade de Medicina de Botucatu"	https://ensaiosclinicos.gov.br/rg/RBR-7xk5nr	<NULL>	Patients 18 years of age or older; with diagnosis of chronic pain; by the HCFMB-Unesp Pain Outpatient Clinic for a period of less than 1 year in an uninterrupted manner; be in use of at least two types of analgesic medication like opioids, anticonvulsants, common analgesics and antidepressants, in a maximum of four times a day; residing in the city of Botucatu and region; and be responsible for the administration and organization of analgesic medications	Patients with low cognitive capacity and illiterate; patients with cancer pain or fibromyalgia; history of non-adherence to other treatments; during the study, of dose adjustments and prescription of other medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7j5xyf	Adherence to physiotherapeutic orientation to practice pelvic floor muscle exercises in women with urinary incontinence	Not yet recruiting	Intervention	2013-08-07	<NULL>	<NULL>	222	Adherence to physiotherapeutic orientation to practice pelvic floor muscle exercises in women with urinary incontinence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7j5xyf	<NULL>	Women with symptoms consistent with urinary incontinence (stress, urge or mixed) and older than 18 years and less than 80 years old.	Exclusion criteria are: virginity, pregnancy, women with gynecological cancer or bladder cancer, women diagnosed with neurological diseases (stroke, multiple sclerosis, parkinsonism, epilepsy, tumor or spinal cord trauma), observed cognitive deficits  (minimental &lt;14), difficulties in performing activities of daily life, not agreeing to participate in the study by signing the consent of the ethics committee,those who can not contract adequately pelvic floor during pelvic floor muscle assessment and women who previously held treatment with  pelvic floor exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-2dhtzh	Adherence to self-care in leprosy in the light of Everett Rogers Theory	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2987	Adherence to self-care in leprosy in the light of Everett Rogers Theory	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Programa de Pós-Graduação em Enfermagem da Universidade Federal da Paraíba	Hospital Universitário Lauro Wanderley	https://ensaiosclinicos.gov.br/rg/RBR-2dhtzh	<NULL>	Patients in treatment with MDT who met the inclusion criteria were considered eligible: age of majority, confirmation of leprosy diagnosis, multibacillary operational classification, with treatment between the second and ninth supervised dose (avoiding termination of the treatment during the intervention process).	The new cases, considering that these situations individuals receive guidance at the time of consultation, and therefore have a prior lack of a pathological condition; those unable to perform activities of self-care due to visual impairment, mental disorder and / or severe physical limitations; and patients with disabilities of cognitive understanding that prevent participation in educational intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-2trzh45	Adjunct effect of Transdermal Systemic Photobiomodulation in Alveolar Bone Graft Surgery	Terminated	Intervention	2023-10-10	<NULL>	<NULL>	6495	Adjunctive effect of Systemic or Point Laser in Secondary Alveolar Bone Graft Surgery	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2trzh45	<NULL>	Have a bilateral transforamen cleft and be able to undergo secondary or tertiary alveolar bone graft surgery with a donor area from the iliac crest	Do not accept participation in the research and/or withdraw from any of its stages; positive test for SARS-cov 2; Modifications in the surgical plan at the time of surgery; presence of a beard or mustache at the time of image acquisition, in order not to compromise the analysis of facial temperature; black patients due to the presence of a greater amount of melanin on the surface of the skin, since the red laser is absorbed by this chromophore and may cause burns with the dose used and standardized for research participants; patients with systemic compromise and not suitable for surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-29z46fh	Adjunctive Vocational Orientation to Good Psychiatric Management for Adolescents with Borderline Personality Disorder: Randomized Clinical Trial	Recruitment completed	Intervention	2023-07-12	<NULL>	<NULL>	7809	Vocational Orientation as a complementary strategy in the treatment of adolescents with Borderline Personality Disorder: effects on clinical symptoms and in positive mental health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-29z46fh	<NULL>	Adolescents; literate; aged 13-17 years; all genders; both sex; with 3 or more criteria for Borderline Personality Disorder; agree to sign the Informed Consent Form	Adolescents with intellectual disabilities (IQ&lt;80); primary psychoses; decompensated bipolar affective disorder; decompensated anorexia; severe neurological problems; conduct disorder with limited pro-social emotions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-3fgtdp	Administration of drugs intramuscular:  in the buttocks region and the side region of the hip	Recruitment completed	Intervention	2016-07-27	<NULL>	<NULL>	940	Administration of drugs intramuscular:  dorsogluteal  region and  the ventrogluteal region	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-02	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-3fgtdp	<NULL>	Active syphilis diagnosis; prescription of Penicillin G Benzatina, intramuscular, for treatment of syphilis; without alterations at the site of injections.	"Allergic to Penicillin G Benzatina;
bedridden; paraplegics; decreased level of consciousness; fear of injection; painful sensation absent or decreased."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-4smj974	Adult eating behavior: an intervention based on Mindful Eating and its impact on food and well-being	Recruitment completed	Intervention	2023-08-09	<NULL>	<NULL>	6319	Adult eating behavior: an intervention based on Mindful Eating and its impact on food and well-being variables	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4smj974	<NULL>	Adult men and women aged between 18 and 59; be literate; have access to and mastery of internet use.	Professionals or students in Nutrition or Psychology; have psychiatric disorder in the acute phase; practitioners of mindfulness, meditation, yoga or similar, in the last 6 months (with formal practice at least once a week); pregnant; have cognitive difficulties that do not allow the understanding of the issues of the instruments used in data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-6c4c6hk	Adverse events evaluation of vaccine against diphtheria, tetanus and whooping cough in children in the city of Goiania - Goias	Data analysis completed	Intervention	2021-05-28	<NULL>	<NULL>	4693	Evaluation of reactogenicity of vaccine in infants tetravalent Goiânia - Go	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-12	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6c4c6hk	<NULL>	Child must be a resident of the city of Goiânia, Goiás; A legal guardian must be present; Belonging to the age group between 2-12 months; There have been exposed to some intramuscular injection in the last 3 days; It is only vaccinated with the vaccine Serum laboratory.	Weight less than three kilograms; Ggestation than 37 weeks; children vaccinated with the vaccine laboratory Bern.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-7mzjqv4	Aerobic exercise and mood states	Data analysis completed	Intervention	2023-06-29	<NULL>	<NULL>	6187	Effects of different intensities of physical exercise on the quinurenine pathway and mood states	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7mzjqv4	<NULL>	Male gender. Aged between 20 and 35 years. Have a training routine with a minimum frequency of 3x/week, for a minimum period of one year. Be considered physically active by the International Physical Activity Questionnaire - IPAQ. Not present any type of psychological or eating disorder. Not chronically on medication. Need to be considered in good health after cardiological evaluation. Cannot have undergone surgery in the last 6 months. Cannot have any physical, muscular and/or joint problems	Inability to comply with the entire experimental protocol for any reason. Non-attendance at the stipulated times between tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-98jdt3	Aerobic exercise of high intensity for treating Apnea: the effects of intensity on the disease, on heart responses, and sleep quality	Recruiting	Intervention	2019-07-22	<NULL>	<NULL>	2831	Aerobic exercise for treating of Obstructive Sleep Apnea: effects of intensity on disease severity, hemodynamics, autonomic resposes and sleep quality	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-98jdt3	<NULL>	Men and women; obstructive sleep apnea (OSA) moderate to severe (apnea-hypopnea index greater than 15 events / hour); diagnosed by nocturnal polysomnography; between 18 and 75 years old; overweight or obese; sedentary; taking stable doses of medication; not having previous treatment for OSA; medical authorization to practice physical activity	Cardiovascular; pulmonary or metabolic disease; resistant hypertension (159/99 mmHg with more than three drugs); pregnant or unable to exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-27j6zg	Aerobic training at different times of day: Vascular and autonomic adaptations in hypertensive elderly	Recruiting	Intervention	2019-12-06	<NULL>	<NULL>	3256	Aerobic training at different times of day: Vascular and autonomic adaptations in hypertensive elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-27j6zg	<NULL>	Men and women; age between 60 and 90 years; hypertensives receiving anti-hypertensive drugs for 4 or more months; neither receiving beta-blockers nor non-dihydropyridine calcium channel blockers; neither chronotype type; inactive or insufficiently active; available to participate in the interventions at both proposed times of day (morning and evening), not taking any hormone replacement.	Presence of cardiovascular diseases beyond hypertension; presence of osteomioarticular problems that unavailable to practice exercise; systolic and diastolic blood pressures higher than 160 and 105 mmHg, respectively; obesity level 2 or above; presence of diabetes with complications or receiving insulin; presence of organ-target damage; presence of complex arrhythmias and/or ischemia during exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-6bsngd	Aerobic training in different volumes and intensities in schoolchildren with risk factors for metabolic syndrome	Recruitment completed	Intervention	2017-03-10	<NULL>	<NULL>	1183	Effects of aerobic training in different volumes and intensities in schoolchildren with risk factors for metabolic syndrome.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-22	Universidade Estadual de Maringá	UNESPAR/ Campus Paranavaí	https://ensaiosclinicos.gov.br/rg/RBR-6bsngd	<NULL>	Be properly enrolled in any school; Be between 10 and 18 years old; To present a free and informed consent form signed by the parents or guardians; Present medical release for physical activity	Do not be aged between 10 and 18 years; Have some physical or mental deficiency; Use controlled medications; Do not present auotorization of the parents and the doctor to practice physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-3ccp383	Aesthetic performance and tolerance evaluation for Profhilo® applications in the treatment of wrinkles and laxity skin of the neck	Terminated	Intervention	2025-10-06	<NULL>	<NULL>	8373	Aesthetic performance and tolerance evaluation of Profhilo® injective intradermal treatment for the skin roughness and laxity of the neck	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2024-03-22	For Trials Pesquisa Clínica Ltda	IBSA Farmaceutici Italia S.r.l.	https://ensaiosclinicos.gov.br/rg/RBR-3ccp383	<NULL>	Female sex; 35-65 years; 3-4 neck roughness/laxity grade according to a clinical reference scale; asking for neck laxity and roughness restoration; available and able to return to the study site for the post-procedural follow-up examinations; accepting to not change their habits regarding food, physical activity, cosmetic and cleansing products for the neck; accepting to not expose their neck to strong UV irradiation (UV session, or sun bathes) during the entire duration of the study, without appropriate sun protection; accepting to sign the informed consent form	Pregnancy; lactation; smoking; alcohol abuse or drug use; non-menopausal volunteers who do not want to use adequate methods of contraception to avoid pregnancy during the study; non-menopausal volunteers who do not want to undergo a pregnancy test at T1 (before the 1st injection) and T3 (1 month after the 1st injection and before the 2nd injection); variation in body mass index (BMI) (± 1) during the study period; performing aesthetic treatments for the skin of the neck (dermal implants, surgical lifting, botulinum toxin, laser, chemical peels) 6 months before the start of the study; who have had permanent fillings in the past; changes in eating habits, physical activity, cosmetic and neck cleaning products during the month preceding the tests; sensitivity to the product or its ingredients (to be questioned by the investigator during the baseline visit); volunteers whose poor adherence to the study protocol is predictable; participation in a similar study concurrently or in the last 9 months; dermatitis; presence of dermatological diseases in the tested area, such as injuries, scars, malformations; recurrent facial/lip herpes; significant clinical conditions in the tested area (e.g. active eczema, psoriasis, severe rosacea, scleroderma, local infections, severe acne); diabetes; endocrinological diseases; liver dysfunctions; kidney dysfunctions; cardiac dysfunctions; lung diseases; cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-92g625	Aesthetic treatment of stains on anterior teeth caused by hypomineralization	Not yet recruiting	Intervention	2020-07-10	<NULL>	<NULL>	3999	Masking enamel demarcates opacities in anterior teeth in patients with Molar-Incisor Hypomineralization: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-25	Universidade do Estado do Rio de Janeiro -UERJ	Universidade do Estado do Rio de Janeiro -UERJ	https://ensaiosclinicos.gov.br/rg/RBR-92g625	<NULL>	The sample will be composed of children and adolescents, between 7 and 18 years old, with MIH, presenting white-creamy opacities in the enamel of at least one incisor	Patients with other dental developmental defects such as amelogenesis, dentinogenesis imperfecta or fluorosis; Patients with fixed orthodontic appliance; Patients with chronic health syndromes or health impairments that requires special care during dental treatment; Incisors with caries lesions or with demarcated opacities of other origins, such as traumatic sequelae in the predecessor primary teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-6ktzzh8	Affective experience and opioid use before anesthesia: a double-blind randomized clinical trial	Not yet recruiting	Intervention	2024-07-22	<NULL>	<NULL>	7147	The affective experience and use of opioids before anesthetic induction: a double blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-08-10	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Faculade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6ktzzh8	<NULL>	Both genders; age range between 18 and 65 years old; classified according to surgical risk as ASA 1 or ASA 2 or ASA 3; according to medical assessment based on health history, physical examination and laboratory tests; subjected to previously scheduled surgery, and may or may not be hospitalized with general anesthesia	"Physical or intellectual inability to respond to the questionnaires, as assessed by the researchers;
Illiterate; patients who have a previous history of an allergic reaction to opioids; chronic opioid users;
users of psychoactive drugs for recreational use; patients with nephropathy, pacemakers and beta blockers"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-7vfx9pv	Affective response to increasing and decreasing intensity physical exercise in adolescents	Not yet recruiting	Intervention	2025-04-10	<NULL>	<NULL>	7912	The affective response to physical exercise of different intensities in adolescents	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7vfx9pv	<NULL>	Healthy volunteers; both genders; aged between 11 and 17 years; agree to participate in the study by signing the consent forms by their guardian and assent by the participant	Self-report of diagnosis of psychiatric disorders; self-report of use of alcohol or drugs; physical inability to perform physical exercise; participant who does not participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-9hc9dz	Agents used for dental sensitivity during whitening: a clinical study	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2984	Evaluation of In-Office Desensitizing Agents used during 35% Hydrogen Peroxide Bleaching: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	São Leopoldo Mandic - SL Mandic	São Leopoldo Mandic - SL Mandic	https://ensaiosclinicos.gov.br/rg/RBR-9hc9dz	<NULL>	Presence of at least 20 permanent teeth (including all anterior teeth); be between 18 and 30 years of age; absence of restorations in the six upper anterior teeth; absence of active caries or periodontal disease; commitment not to use tobacco during the study period.	History of any systemic disease that may interfere with the results; have undergone any previous bleaching treatment; patients using analgesics and / or anti-inflammatories; pregnant or breastfeeding patients; Patients smokers; teeth with tetracycline stains; patients with orthodontic appliances or removable prostheses; patients with gingival retraction or with cracks in the enamel; patient with previous dental sensitivity; patient with poor oral hygiene and presence of active caries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-9n5jbw	Aging of the immune system, Frailty and physical exercise in the elderly	Not yet recruiting	Intervention	2020-03-16	<NULL>	<NULL>	4393	Imunosenescence, Frailty and physical exercise in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Medicina de Jundiaí	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-9n5jbw	<NULL>	Age equal to or greater than 60 years; understand the instructions and guidelines about the study and freely agree to participate.	The exclusion criteria will be: probable cognitive impairment identified using the 10-point cognitive screening instrument (10-CS) with a final score of 0 to 5 points; any contra-indication for the VIVIFRAIL program (acute heart attack (recent 3-6 months) or unstable angina; uncontrolled atrial or ventricular arrhythmias; aortic dissecting aneurysm; severe aortic stenosis; acute endocarditis / pericarditis; uncontrolled high blood pressure (higher than 180/100 mmHg);  acute thromboembolism; acute or severe heart failure; acute or severe respiratory failure; uncontrolled postural hypotension; uncontrolled acute decompensated diabetes mellitus or low blood sugar; a recent fracture in the last month (strength training); any other circumstance the doctors believes prevents doing physical activity, life-expectancy less than 12 months, permanent or temporary inability to walk; localized loss of strength and aphasia due to severe stroke; severe impairment of motor skills, speech or affectivity associated with Parkinson&apos;s disease in an advanced or unstable stage; severe hearing or vision deficits making communication very difficult; older adults who have cancer and autoimmune diseases in activity and follow-up; elderly people with cancer diagnosed in the last 3 years; inability to perform the Short Physical Performance Battery (SPPB) (score of zero); any limb amputation. Also, older patients who have performed physical activity or physical therapy in the 6 months preceding the start of the intervention will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-5ystjk9	Aging Well: Nutrition, Food Education, and Quality of Life	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7799	Promoting healthy aging: Food and Nutrition Education and Quality of Life	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-10	Pontificia Universidade Católica de Campinas - PUC/ CAMPINAS	Pontificia Universidade Católica de Campinas - PUC/ CAMPINAS	https://ensaiosclinicos.gov.br/rg/RBR-5ystjk9	<NULL>	People aged 60 or over; male and female; independent; participants in the Vitalità program at the Pontifical Catholic University of Campinas	Older adults with self-reported cognitive diseases; Those who do not sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:58
RBR-6yk2kgv	Ahmed ClearPath and Baerveldt non-valved drainage devices in the treatment of Glaucoma	Recruiting	Intervention	2025-01-25	<NULL>	<NULL>	7681	Efficacy and safety of implanting Ahmed ClearPath and Baerveldt non-valved drainage devices in the treatment of refractory and/or high-risk Glaucoma. Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6yk2kgv	<NULL>	Best-corrected visual acuity of Light Perception (LP) or better, with good light projection. Diagnosis of refractory glaucoma by the attending physician: intraocular pressure not clinically controlled with maximum tolerated therapy, presence of previous fistulizing glaucoma surgery or cataract surgery, contraindication to fistulizing surgery. Indication for drainage tube implantation by the attending physician, with or without association with cataract surgery or vitrectomy. Age 18 years or older. Both sexes	Under 18 years of age. Previous drainage tube implantation procedure. Presence of retinal and/or choroidal detachment. Visual acuity with no light perception. Presence of ocular tumor. Patients unable to undergo the proposed examinations or to remain in the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-6q3w5k7	Air-volume measurement during newborns respiration while breathing calmly using electrical impedance tomography	Recruiting	Observational	2021-12-01	<NULL>	<NULL>	5064	Evaluation of tidal volume in spontaneous ventilation by electric impedance tomography in eupneic newborns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-08-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Timpel S.A	https://ensaiosclinicos.gov.br/rg/RBR-6q3w5k7	<NULL>	Newborns with 32 weeks of corrected gestational age at the moment of the data acquisition; without the need of ventilatory support; the ones considered eupneic at the moment of the data acquisition	Newborns with cardiac pacemaker or other electronic implantable device; newborns with skin lesions in the area where the electrical impedance tomography belt will be placed; newborns with genetic syndromes or important cardiac malformations; newborns who could not be calmed and became too agitated during the assessments; newborns who had been previously mechanically ventilated or with history of pulmonary compromise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-4h27jmk	AK001 Probiotic and Type 2 Diabetes: Efficacy and Safety Evaluation	Not yet recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9016	Safety and efficacy evaluation of AK001 probiotic supplementation in patients with Diabetes Mellitus 2	<NULL>	2-3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-30	Hospital Ana Nery	<NULL>	<NULL>	<NULL>	Individuals aged 30 to 65 years; of both sexes; with a confirmed diagnosis of Type 2 Diabetes Mellitus (T2DM); participants on stable metformin therapy (for at least 4 weeks at a stable dose); informed consent	Participants not receiving pharmacological treatment for glycemic control; participants who used probiotics and/or prebiotics in the month prior to the study inclusion visit; participants using antibiotics; presence of active autoimmune or infectious diseases; participants using other glucose-lowering agents beyond those permitted by the protocol (metformin); patients using hyperglycemic medications (e.g., glucocorticoids, thiazides, phenytoin, estrogens, beta-blockers, pentamidine, interferon, and others); chronic or acute kidney disease or any other medical condition, according to the investigator’s assessment; chronic pain from causes other than diabetic neuropathy; pregnancy or breastfeeding; allergy to any of the active ingredients or excipients of the product under study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-48mkgz7	Alcohol addiction: treatment with omega-3 to prevent alcohol use	Terminated	Intervention	2021-10-05	<NULL>	<NULL>	4940	"Alcohol dependence: longitudinal study about relapse prevention using
polyunsaturated fatty acids (PUFAs)"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-06-09	Universidade Federal de São Paulo	Associação Fundo de Incentivo à Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-48mkgz7	<NULL>	Male; age between 18 and 70 years; severe alcohol use disorder according to DSM-5 criteria (Diagnostic and Statistical Manual of Mental Disorders 5th. edition)	Volunteers with a history of allergic processes to fish; severe pathological history of hepatic, cardiovascular, renal, pulmonary, endocrine, neurological and psychiatric disorders with psychotic symptoms such as schizophrenia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-2b6r7q	Aleatory clinical trial: evaluation of the effect of an application for mobile phones as an aid in the prevention of Bottle Caries	Not yet recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2237	Randomized clinical trial: evaluation of the effectiveness of an application for mobile phones as an aid in the prevention of early childhood caries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-30	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2b6r7q	<NULL>	"Children aged 36-60 months; both genders; 
with high risk of dental caries; Parents or guardians must have a smartphone with Internet access; Parents or guardians must have the WhattsApp application installed on their smartphone"	Children with caries lesions with ICDAS greater than or equal to 4; Parents or guardians who can not access WhattsApp frequently	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-8bt38c	Allergic inflammatory cytokine analysis and concentration of nickel ions in patients with orthodontic appliance	Recruitment completed	Intervention	2019-10-14	<NULL>	<NULL>	3085	Analysis of type IV hypersensitivity cytokines and their correlation with the concentration of nickel ions in saliva and urine of patients under orthodontic treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-25	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8bt38c	<NULL>	Healthy volunteers; both genders; non smokers; Minimum age of 12 years, with Class I malocclusion, Angle; No previous orthodontic treatment; Without missing teeth; Without extensive metal restorations; No systemic diseases.	Patients who do not sign the free and informed consent; Patients on immunosuppressive drugs; Patients using drugs that involve hypersensitivity as antibiotics or ati-inflationary.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-4qqbzzz	Alpha-lipoic acid as an adjuvant in the treatment of depression	Recruiting	Intervention	2025-04-17	<NULL>	<NULL>	7938	Clinical study of Alpha-Lipoic Acid as an adjuvant drug for the treatment of Depression	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-03-18	Departamento de Fisiologia e Farmacologia da Universidade Federal do Ceará	Departamento de Fisiologia e Farmacologia da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4qqbzzz	<NULL>	Male or female participants; aged between 18 and 50 years; diagnosed with moderate depression, assessed using the Hamilton scale; undergoing stable treatment with an antidepressant from the Selective Serotonin Reuptake Inhibitor class for at least four weeks before inclusion in this study; receiving care at the Psychiatry Outpatient Clinic of the Walter Cantídio University Hospital; willing to maintain this medication during the study; capable of understanding the nature and objectives of the study, including its risks and benefits, and willing to cooperate with the researcher and comply with the protocol requirements, as confirmed by signing the Informed Consent Form; patients who do not have clinical conditions that could interfere with the results, such as uncontrolled chronic diseases (diabetes, heart disease, liver disease, and kidney disease)	Participant with a history of severe psychiatric disorders (e.g., bipolar disorder, schizophrenia) or substance abuse; history of autoimmune or inflammatory diseases that may alter cytokine production, or any condition that affects the metabolism of alpha-lipoic acid; known history of hypersensitivity to alpha-lipoic acid or any component of the formulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-5tyrtt	Alteration of kidney function in patients undergoing video surgery	Recruiting	Intervention	2019-03-15	<NULL>	<NULL>	2527	Variations in NGAL (Neutrophil Gelatinase-Associated Lipocalin) in patients submitted to pneumoperitoneum with low and standard pressure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Santa Casa de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5tyrtt	<NULL>	Imageological diagnosis of cholelithiasis; formal indication of cholecystectomy; age between 18 and 60 years; both sexes.	Acute pancreatitis; acute cholecystitis. Presence of baseline chronic kidney disease (estimated creatinine clearance by the Cockcroft-Gault equation &lt;90).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5yr2yx	Alterations in gastric mucosa of cirrhotic patients	Data analysis completed	Observational	2015-06-11	<NULL>	<NULL>	515	The effect of portal hypertension on elevated gastric antrum erosions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	Faculdade de Ciências Médicas da Santa Casa de São Paulo - FCMSCSP	Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-5yr2yx	<NULL>	The study included 69 volunteers of both sexes; from 18 to 80 years of age; presenting elevated antral erosions during endoscopy; with or without portal hypertension.	The volunteers who had prior treatment to eradicate Helicobacter pylori; who had recently used antibiotics or who have not agreed to participate in the study were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-2bnc6y	Alternating red and infrared laser photobiomodulation therapy for temporomandibular disorders: study protocol for a randomized double-blind clinical trial	Recruiting	Intervention	2018-04-12	<NULL>	<NULL>	3301	The influence of educational measures and low-level laser phototherapy on temporomandibular disorders: effects on pain, mandibular mobility and quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2bnc6y	<NULL>	Participants aged between 18 and 55 years;  diagnosed with myalgia and arthralgia, with or without disc displacement; reporting pain or discomfort related to the TMJ area, greater than 4 cm in a visual analogic scale; literated.	Participants that carry muco-supported dental prostheses, orthopedic or orthodontic appliances; whose state of health contraindicates some of the therapies; who present teeth in severe precarious conditions, as an indication of endodontic treatment; carriers of rheumatoid arthritis; who are using any analgesic or antiinflammatory medication; carriers of congenital problems with involvement of TMJ or orofacial and cervical skull region; with recent mandibular fractures; or pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8by7qqg	Alternative teaching methodology for diagnosing dental enamel defects	Recruitment completed	Intervention	2026-02-18	<NULL>	<NULL>	8880	Improvement in the diagnosis of enamel developmental defects: proposal of an alternative teaching methodology	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-08	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Participants of both genders; of any age; who are undergraduate students in Dentistry at the Faculty of Dentistry of the Federal University of Minas Gerais; Students who have had contact with subjects related to amelogenesis, including Embryology, Pathology, and Dental Anatomy	Students who have already attended a specific class on developmental defects of enamel; Students who have direct contact with this type of pathology in their daily clinical practice for example participants in extension projects involving amelogenesis or those with research projects or undergraduate thesis focused on this theme; Students who present any disability that prevents them from participating in the research activities	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-6kcxvrc	Alternative therapies for the control of  anxiety and discomfort after wisdom molar extraction	Recruiting	Intervention	2022-03-10	<NULL>	<NULL>	5271	Alternative therapies for the control of anxiety, pain, edema, trismus and surgical disconfort in patients undergoing third molar surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-05	Departamento de Estomatologia da Universidade Federal do Paraná	Departamento de Estomatologia da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6kcxvrc	<NULL>	Adults over 18 years of age; both sexes; no changes in general health; asymptomatic; will undergo surgery to remove third molars on both sides, with similar radiographic positions bilaterally, requiring osteotomy or odontosection.	History of taking pain or anxiety medication within 15 days prior to the study; history of hypersensitivity to drugs, substances or materials used in this experiment; pregnant women; lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9vs4zyr	Alternative Therapies in Speech Therapy: how they assist in speech and writing	Recruitment completed	Intervention	2026-04-18	<NULL>	<NULL>	9117	Integrative and Complementary Practices in Speech Therapy: application in the area of oral and written language	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-09	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Children with developmental stuttering aged from 3 years to 11 years and 11 months adolescents aged from 12 years to 17 years and 11 months and adults aged 18 years and older of both sexes presenting stuttering with or without a familial component. Phonological disorder children aged from 4 to 8 years of both sexes. Oral language disorder children aged from 2 to 6 years presenting delay in oral language development. Written language disorder children in the early stages of literacy corresponding to first to fifth grade with ages ranging from 5 to 12 years	Cases with evident neurological alterations; hearing loss; associated syndromes and severe mental disorders, such as psychosis and autism, will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-6ffdnx	Alternatives schedules against hepatitis b in homeless person in Goias	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1830	Randomized clinical trial of alternatives schedules against hepatitis b and serum epidemiological study of syphilis and caused infections human immunodeficiency virus and viral hepatitis in homeless person in Goias	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-03-05	Faculdade de Enfermagem Universidade Federal de Goiás	Faculdade de Enfermagem Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6ffdnx	<NULL>	Man aged 18 years or over; who have lived in a street situation for at least 30 days; who are in the place of data collection for a maximum of 30 consecutive days and who are susceptible to the hepatitis B virus.	Man with confirmed serological diagnosis of HIV; with some contraindication of the vaccine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8h45h43	Altitude-simulated Training applied to team sport athletes	Data analysis completed	Intervention	2025-09-26	<NULL>	<NULL>	8316	Acute and chronic responses to Inter-effort Recovery Hypoxia associated with Small-sided Games and Sprint Interval Training in team sport athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Escola de Educação Física e Esporte de Ribeirão Preto, Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8h45h43	<NULL>	Male handball athletes aged between 18 and 35 years	Failure to complete two or more sessions of the chronic protocol; failure to complete one session of the acute protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-877q82j	Amamentacoach: a mobile strategy for breastfeeding reterm infants	Not yet recruiting	Intervention	2021-03-02	<NULL>	<NULL>	4562	Nursing Coaching by App: an innovative approach to breastfeeding preterm infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-877q82j	<NULL>	The following inclusion criteria will be considered for mothers, having given birth at the University Hospital of the State University of Londrina; referring to the desire to breastfeed; not having any contraindications to breastfeeding; having a smatrphone and presenting voluntary agreement to participate in the study and signing the informed consent form. The following inclusion criteria will be considered for infants, gestational age of birth less than 37 weeks; absence of congenital malformations, genetic syndromes, hypoxic-ischemic encephalopathy and or conditions that imply contraindication or impediment to breastfeeding.	Maternal death during the study; death of the baby less than one week after inclusion in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-9vh37wr	Amamentar durante a vacinação ajuda a reduzir a dor do bebê aos dois meses de vida	Recruiting	Intervention	2022-11-04	<NULL>	<NULL>	5705	Effectiveness of Breastfeeding in reducing Pain induced by the Pentavalent Vaccine in the second month: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal do Piauí - Campus Amílcar Ferreira Sobral	Universidade Federal do Piauí - Campus Amílcar Ferreira Sobral	https://ensaiosclinicos.gov.br/rg/RBR-9vh37wr	<NULL>	Infants aged between 60 and 89 days; who are breastfed; who were born with a gestational age of 37-42 weeks; no visible and/or reported congenital malformations by the mother; in need of Pentavalent vaccination.	Infants who are not breastfed directly from the breast; who have used analgesics in the last 48 hours before vaccination; who are agitated before vaccination; who have a history of hypersensitivity to any component of the immunobiological and/or other contraindications established by the Ministry of Health (BRASIL, 2016); or develop an allergic reaction such as a rash to the vaccine given.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:18
RBR-5d25w3	Amazonian Oil intake on Metabolic Syndrome	Recruiting	Intervention	2019-10-08	<NULL>	<NULL>	3045	Effect of amazonian oil intake on Metabolic Syndrome patients	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-11	Lívia Martins Costa e Silva	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-5d25w3	<NULL>	Individuals between 30 and 65 years old; both genders; diagnosed with MS according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III, 2001); consulted at the Nutrition Clinic of the João de Barros Barreto University Hospital (HUJBB).	Patients with abnormal thyroid function; chronic kidney and / or liver disease; patients with neurodegenerative diseases such as dementia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-2qz7vwt	Ammonia free cariostatic for dentine caries lesions treatment	Recruitment completed	Intervention	2023-10-31	<NULL>	<NULL>	6555	Silver Diamine Fluoride free of Ammonia (Riva Star Aqua) for dentine Caries lesions - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-08	Centro Universitário UNIESP	Centro Universitário UNIESP	https://ensaiosclinicos.gov.br/rg/RBR-2qz7vwt	<NULL>	Children from both genders whose parents accept and sign the informed consent form. Children from 3 to 10 years old that allows treatment will be included (good overall behaviour). Primary molars with cavitation into dentine	Children whose parents do not sign the consent form. Children who are absent on the day of treatment. Children who do not cooperate with the treatment. Teeth with dentine caries lesions with signs and symptoms of irreversible pulpitis and/or pulp necrosis (clinical pulp exposure, spontaneous pain, presence of fistula or abscess close to the tooth to be treated). Teeth with enamel defects (amelogenesis imperfecta, hypomineralization or hypoplasia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-97kx5jv	An Alksite Composite material to Restore Endodontically Treated Teeth: A randomized control trial study	Data analysis completed	Intervention	2023-01-19	<NULL>	<NULL>	5835	Evaluation of a Bioactive Composite for the Restoration of Endodontically Treated Teeth: A Prospective Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo - FORP USP	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo - FORP USP	https://ensaiosclinicos.gov.br/rg/RBR-97kx5jv	<NULL>	Both genders; Presence of 1 lower molar (First or Second) treated endodontically requiring direct restoration; Endodontic treatment performed for a maximum of 6 months; Presence of antagonist tooth in the dental arch; No parafunctional habits; No temporomandibular disorder; age 18 to 40 years	Teeth with extensive loss with indication of indirect restorations were excluded from the study; teeth with root involvement such as fractures or cracks, patients with poor oral hygiene, patients with chronic or aggressive periodontitis, teeth that were endodontically treated for more than 6 months and teeth without provisional cavity sealing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-2rkkgn	An e-Health system for monitoring patients with Arterial Hypertension	Recruiting	Intervention	2019-08-28	<NULL>	<NULL>	4530	e-Lifestyle system: an e-Health solution for monitoring the health conditions of patients with Arterial Hypertension	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-28	Universidade de Passo Fundo	Secretaria Municipal de Saúde do Munícipio de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-2rkkgn	<NULL>	"Cognitive ability confirmed by the Mini-Mental State Examination (both groups).
Current medical follow-up for the treatment of hypertension in the public health system of the city of Passo Fundo, RS, Brazil (both groups). Possibility to assess blood pressure in drugstores, hospitals, Family Health Strategies, or Centers for Comprehensive Health Care (both groups). Having an Android smartphone, version 4.3 or higher (Intervention Group). Being familiar with the use of applications (Intervention Group). Having internet access in the smartphone (Intervention Group)."	Age less than 18 years. Age greater than 80 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-57dgft9	An early physical therapy program for anterior knee pain	Recruiting	Intervention	2025-10-02	<NULL>	<NULL>	8348	Effectiveness of early physical therapy compared to delayed physical therapy for patients with patellofemoral pain: a multicentre randomized clinical trial	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-20	Universidade Estadual Paulista Julio de Mesquita Filho	Faculdade de Ciências e Tecnologica da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-57dgft9	<NULL>	Young adult males and females; aged 18-35 years old; with anterior knee pain when performing at least two functional activities; self-report recent- (4 to 12 weeks) or late-onset (more than 6 months) pain; insidious-onset pain in one or both knees; worst pain level in the last 4 weeks of at least 3 on a 0-10 numeric pain scale	Clinical evidence of any other knee disorder/condition; history of recent lower back or limb injury (less than 6 months); recent engagement to a physical therapy program (less than 1 month); history of knee or lower limb surgery; low back pain with leg pain; inability to read or understand english, portuguese, or french-speaking Belgian; presence of heart or neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-7yq9fh6	An Educational Intervention to Improve the Use of the Internet Regarding Health by adolescents	Recruitment completed	Intervention	2023-11-28	<NULL>	<NULL>	6617	An Educational Intervention to Improve Health-Related Internet use by adolescents: Randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal de Minas  Gerais	Universidade Federal de Minas  Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7yq9fh6	<NULL>	Adolescents between 13 and 18 years old with low levels of digital health literacy obtained by the Brazilian version of the eHeals questionnaire (Maschio, da Silva, 2019)	Adolescents who have any type of cognitive impairment; Adolescents who are not literate; Adolescents who do not have WhatsApp	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-76cwjd	An Efficacy and Safety Study of JNJ- 56021927 (ARN-509) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy	Not yet recruiting	Intervention	2016-03-30	<NULL>	<NULL>	773	56021927PCR3003 - A Randomized, Double-blind, Placebocontrolled Phase 3 Study of JNJ- 56021927 in Subjects with High-risk, Localized or Locally Advanced Prostate Cancer Receiving Treatment with Primary Radiation Therapy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-12-15	Fundação Pio XII - Hospital de Câncer de Barretos	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-76cwjd	<NULL>	Inclusion Criteria:Age &gt;= 18 years; Indicated and planned to receive primary radiation therapy for prostate cancer; Histologically confirmed adenocarcinoma of an intact prostate, and 1 of the following at diagnosis: 1) Gleason score &gt;=8 and &gt;=cT2c, 2) Gleason score &gt;=7, PSA &gt;=20 nanogram per mililiters (ng/mL), and &gt;=cT2c; Charlson comorbidity index (CCI) &lt;=3 - An Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) grade of 0 or 1; Adequate liver function: aspartate aminotransferase (AST), alanine aminotransferase (ALT), &lt;2 * upper limit of normal (ULN) and total bilirubin &lt;1.5 * ULN - Participants who are sexually active (even men with vasectomies) and willing to use a condom and agree not to donate sperm during the trial ; Signed, written, informed consent; Be able to swallow whole study drug tablets	"Exclusion Criteria:Presence of distant metastasis, including pelvic nodal disease below the iliac bifurcation &gt;2 cm in the short axis - Prior treatment with GnRH analogue or anti-androgen or both for &gt;3 months prior to randomization - Bilateral orchiectomy 
; History of pelvic radiation; Prior systemic (eg, chemotherapy) or procedural (eg, prostatectomy, cryotherapy) treatment for prostate cancer; History of seizure or condition that may predispose to seizure (including, but not limited to prior stroke, transient ischemic attack or loss of consciousness &lt;= 1 year prior to randomization; brain arteriovenous malformation; or intracranial masses such as schwannomas and meningiomas that are causing edema or mass effect); Prior treatment with enzalutamide, abiraterone acetate, orteronel, galeterone, ketoconazole, aminoglutethimide, estrogens, megestrol acetate, and progestational agents for prostate cancer; Prior treatment with radiopharmaceutical agents (eg, strontium-89) or immunotherapy (eg, sipuleucel-T) for prostate cancer; Prior treatment with systemic glucocorticoids ?4 weeks prior to randomization or is expected to require long-term use of corticosteroids during the study; Use of 5-alpha reductase inhibitors (eg, dutasteride, finasteride) &lt;=4 weeks prior to randomization; Use of any investigational agent &lt;=4 weeks prior to randomization; Current chronic use of opioid analgesics for &gt;=3 weeks for oral or &gt;7 days for non-oral formulations; Major surgery &lt;=4 weeks prior to randomization; Current or prior treatment with antiepileptic medications for the treatment of seizures;  Gastrointestinal conditions affecting absorption; Known or suspected contraindications or hypersensitivity to JNJ-56021927, bicalutamide or GnRH agonists or any of the components of the formulations - Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-2pk58p	"An Efficacy and Safety Study of Ustekinumab in Participants With Active Nonradiographic Axial
Spondyloarthritis"	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	772	CNTO1275AKS3003 - A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Ustekinumab in the Treatment of Subjects With Active Nonradiographic Axial Spondyloarthritis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-06-30	CPCLIN - CENTRO DE PESQUISAS CLINICAS LTDA	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-2pk58p	<NULL>	Research participants should be between 18 and 50 years of age.Rresearch participants should be classified as having NR AxSpA, based on the ASAS criteria 2009.Must present diagnostic nr-AxSpA, according to the criteria of 2009 ASAS, for 5 years.Must be 45 years old at onset of nr-AxSpA .In selection or within 3 months of selection, research participants are to present active inflammation on MRI highly suggestive of sacroiliitis associated with spondyloarthritis and should not present radiographic sacroiliitis that meets the 1984 (New York criteria modified as confirmed by an X-ray rated by central readers ) .Must present symptoms of active disease at screening and at baseline, as evidenced by both BASDAI score 4 as by a score of VAS 4 of total back pain, each on a scale of 0 to 10.Must present an inadequate response to at least two NSAIDs over a period of 4 weeks, in total, with the maximum doses recommended NSAID (s) or be unable to receive a full period of 4 weeks of treatment with most NSAIDs because of intolerance, toxicity or contraindications for NSAIDs.Research participants previously treated with an anti-TNF biologic agent must be: primary or secondary responders to at most one anti-TNF agent or intolerance present documented maximum one anti-TNF treatment or have discontinued at most 1 anti-TNF agent due to lack of efficacy / safety .IF are using other NSAIDs or analgesics for nr-AxSpA, research participants should be receiving a stable dose for at least 2 weeks prior to first administration of study drug. If are not currently using NSAIDs or other analgesics for nr-AxSpA, research participants must not have received NSAIDs or other analgesics for nr-AxSpA for at least 2 weeks prior to first administration of the drug estudo.If are using corticosteroids oral, research participants should be receiving a stable dose equivalent to 10 mg of prednisone / day for at least 2 weeks prior to first administration of the study drug .If currently are not using corticosteroids, the research participants must not have received oral corticosteroids for at least 2 weeks prior to first administration of the study drug .If are using methotrexate, sulfasalazine or hydroxychloroquine, research participants should have started treatment at least 3 months prior to the first dose of study drug and should not present no serious toxic side effects attributable to these DMARDs.	Present radiographic sacroiliitis that meets the 1984 New York modified criteria. Present other inflammatory diseases that may confound the ratings of the benefit of treatment with ustekinumab, including, among others: rheumatoid arthritis, systemic lupus erythematosus or Lyme. Women that is pregnant, breastfeeding or planning a pregnancy or man that bear a child in a woman during inclusion in the study or within 5 months after receiving the last dose of the study drug .Have received any systemic immunosuppressant or DMARD other than MTX, SSZ or HCQ within 4 weeks before the first administration of the study drug .Have received leflunomide within 3 months before first dose of study medication or receiving leflunomide within 12 months prior to first administration of study drug and not having undergone a drug elimination procedure.Have received corticosteroids epidural, intra-articular, IM or IV, including adrenocorticotropic hormone during 4 weeks prior to the first administration of the study drug .Have ustekinumab or any other agent whose target is IL-23.Have prior received more than one anti-TNF agent .Have received infliximab or biosimilar infliximab within 12 weeks before the first administration of the study drug.Have received adalimumab, golimumab, certolizumab pegol. etanercept within 6 weeks prior to the first administration of the study drug .Have received prior biological treatment other than anti-TNF before the first dose of the study drug .Have ever received tofacitinibe or any other inhibitor of Janus quinases.Present any known hypersensitivity to human protein immunoglobulin .Have used citotoxics drugs .Present a history of active granulomatous disease before selection.Have received vaccination with Bacillus Calmette-Guérin within the 12 months prior to selection .Present a chest radiograph within the previous 3 months the first dose of study drug to show a suggestive abnormality of malignancy or current active infection, including  TB. Have presented a mycobacterial nontuberculous infection or oportunist infection.Have received, or is expected to receive any vaccination with alive virus or alive bacteria in the 3 months prior to the first administration of study medication during the study or within 3 months after the last administration of the study drug .Present one history of joint prosthesis infected or have received antibiotics for a suspected prosthetic joint infection. have presented a serious infection or have been hospitalized because of an infection or have been treated with IV antibiotics for an infection within the two months prior to the first administration of study drug. Presenting a history of infectious disease or current infectious disease, chronic or recurrent. Research participant present a history of positivity for antibodies to HIV or tested positive for HIV in selection. Present infection for Hepatitis B.Research Participantes who are positive for antibodies to hepatitis C.Present signs or current symptoms of kidney disease, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, cardiac, neurological, brain or severe psychiatric, progressive or not controled. Present a known history of lymphoproliferative disease. The research participant presents a history of malignancy within 5 years prior to selection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-6tjmw3	An Electronic Program to help people decide if they want to quit smoking	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1757	An Electronic Program to help people make the decision to quit smoking	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-04	Fundação Amparo a Pesquisa do Estado de Minas Gerais	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	https://ensaiosclinicos.gov.br/rg/RBR-6tjmw3	<NULL>	Adult smokers undergoing treatment State Center for Specialized Attention of Juiz de Fora and who sign the free and informed consent form.	Smoker users who, at any time, request the cancellation of the signed free informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9b969b	"An Electronic Program to help people to take
decision to quit smoking"	Recruiting	Intervention	2016-04-10	<NULL>	<NULL>	792	An Electronic Program to help people make the decision to quit smoking	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-04	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	https://ensaiosclinicos.gov.br/rg/RBR-9b969b	<NULL>	Smokers assets; age above 18 years; of both sexes; in the treatment at the Centro Hiperdia Minas -Juiz de Fora and e Serviço de controle de Hipertensão; Diabetes e Obesidade da Prefeitura Municipal de Juiz de Fora who signed the free and informed consent.	Active smokers under 18	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-6t4j85	An evaluation of a medicinal herb as a treatment for Parkinson’s disease	Not yet recruiting	Intervention	2018-09-10	<NULL>	<NULL>	2184	A phase 2, double-blind, randomized, controlled trial of the safety and efficacy of Banisteriopsis caapi versus placebo in patients with Parkinson´s disease	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-09-02	Hospital Universitário Clementino Fraga Filho - UFRJ	Hospital Universitário Clementino Fraga Filho - UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-6t4j85	<NULL>	40 l-dopa treated patients (both genders) with Parkinson’s disease fulfilling the Queen Square Brain Bank Criteria with mild to moderate motor fluctuations will be recruited.	Demented patients with the Mini Mental Status Examination Score, women of childbearing age and those receiving monoamine oxidase inhibitors or amantidine were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-8hfcz8	An exercise program for diabetic elderly based on impairment of feet and its influence on the balance	Recruitment completed	Intervention	2015-08-13	<NULL>	<NULL>	579	An exercise program for diabetic elderly based on sensoriomotor changes of feet and their repercussions in the balance: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-03	Centro de Ciências da Saúde da Universidade Estadual de Maringá	Centro de Ciências da Saúde da Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-8hfcz8	<NULL>	Elderly; above 60 years old; Diabetes Mellitus type II;  independent for activities of daily living.	Elderly with neurological consequences; vascular diseases; great alterations of balance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-5r9xzbq	An Exergames or PhysicalEducation bouts benefits subsequent inhibitory control in Autism Spectrum Disorder children	Data analysis completed	Intervention	2024-04-15	<NULL>	<NULL>	6938	Acute effects of Exergames on the executive function of children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Católica de Brasília	Escola Classe 10 de Taguatinga	https://ensaiosclinicos.gov.br/rg/RBR-5r9xzbq	<NULL>	Those enrolled at Escola Classe 10 in Taguatinga/DF who were diagnosed with Autism Spectrum Disorder (ASD) according to the Diagnostic and Statistical Manual of Mental Disorders - DSM-5 (APA, 2014). No history of diseases such as physical, pulmonary or cardiac malformations. Boys and girls aged between 6 and 12	Non-verbalized Autism Spectrum Disorder (ASD); with intellectual impairment (IQ below 70); ages below 6 and above 12 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-4d7kgrw	An internet-delivered pain and exercise education program for low- and middle-income individuals with back pain	Not yet recruiting	Intervention	2024-04-02	<NULL>	<NULL>	6907	Efficacy and equity of exercise combined with Education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-04	Universidade Federal dos Vales de Jequitinhonha e Mucuri	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4d7kgrw	<NULL>	Patients over the age of 18 who have had nonspecific low back pain for at least 3 months; able to read and understand Portuguese; have access to the internet	Suspected or confirmed severe spinal pathology; fracture; metastatic diseases; inflammatory or infectious diseases of the spine; generalized neurological disorder; previous history of spine surgery in the last 12 months; pregnancy; and contraindications to exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-9y2p2g	An intervention with sit-stand table for decrease sedentary behavior in office workers with overweight and obesity?	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2858	Can sit-stand table usage affect the level of physical activity and body composition in office workers with overweight and obesity?	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-21	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9y2p2g	<NULL>	To be eligible, the workers must report not suffering from chronic systemic health problems; performing computer work for at least four hours (continuous or not) in an ordinary working day; having been performing computer work for at least five years; having been off work for no more than one month during the previous year; workplace that would allow the installation and use of a sit-stand desk for six months.	Do not consent to the Free and Informed Consent Form; give up the evaluation stages, or do not use the table properly; present some acute musculoskeletal discomfort during the study intervention; present obesity II or III; women in the gestational period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-5zdnw6t	An online-based Nutritional Intervention study to promote a healthy diet among Amazonian schoolchildren (Cruzeiro do Sul/Acre-Brazil)	Not yet recruiting	Intervention	2023-03-30	<NULL>	<NULL>	5976	Remote Nutritional intervention to promote healthy eating practices among Amazonian schoolchildren: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-20	Faculdade de Saúde Pública da Universidade de São Paulo	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5zdnw6t	<NULL>	Being a parent or guardian of a 7- to 8-year-old schoolchild (both genders); who is a participant in the Maternal-Infant Birth Cohort Study in Acre; be literate; and have access to a cell phone with internet access	Não ter acesso semanal à internet; não ter disponibilidade para acompanhar o estudo durante as 24 semanas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-462vwq5	An oral inflammatory disease and the relationship in the development of nosocomial pneumonia	Data analysis completed	Observational	2023-11-28	<NULL>	<NULL>	6615	Periodontitis in the development of ventilator-associated Pneumonia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-01	Centro de Ciências Biológicas e da Saúde CCBS - UNIOESTE	Centro de Ciências Biológicas e da Saúde CCBS - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-462vwq5	<NULL>	Individuals over 18 years of age; both genders; admitted to the General ICU of Hospital Universitário do Oeste do Paraná; patients on mechanical ventilation for the first 72 hours; with at least six teeth	Patients with severe maxillofacial trauma that made examination difficult; using complete dentures (upper and lower); pregnant women; immunosuppressed; using any anti-inflammatory and antibiotic for more than three days; serious medical or surgical complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-93wpsf	An Pilates session reduces Blood Pressure in hypertensive patients	Recruitment completed	Intervention	2017-11-09	<NULL>	<NULL>	1472	Acute Blood Pressure behavior after a Pilates session in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-08	Universidade Salgado de Oliveira	Universidade Salgado de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-93wpsf	<NULL>	Prehypertensive and hypertensive volunteers; Both sexes; Nonsmokers, height between 1.57 cm and 1.85 cm; Body weight between 58 kg and 97 kg; Age group from 45 to 67 years.	Volunteers with Diagnosis of cardiovascular, respiratory, metabolic or locomotor diseases; Uncontrolled hypertension (systolic pressure 160 mmHg or diastolic pressure and 105 mmHg at rest); Change of medication; Pilates practitioners for more than two consecutive months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-79sm4vd	Analgesia after dental implant surgeries	Not yet recruiting	Intervention	2022-02-14	<NULL>	<NULL>	5210	Postoperative analgesia in Implant Dentistry	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-79sm4vd	<NULL>	Adult patients (aged 18 years or older), of both sexes, who need surgery to install at least 3 dental implants or dental implant protocols, with the objective of prosthetic rehabilitation will be included.	"Individuals will be excluded:
- who present a previous picture of chronic or acute pain, related or not to the oral cavity,
- in chronic or acute systemic use (in the 48 hours prior to the procedure) of analgesic, anti-inflammatory and/or muscle relaxant,
- with difficulty in understanding instructions (cognitive changes), which impair the application of the scales proposed by the study, such as illiterate patients, with inability to numerically notate and write the pain parameters proposed by the study,
- with contraindication for the use of ibuprofen,
- with contraindication for the use of paracetamol associated with codeine."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-2g3hpyc	Analgesia after Infiltration at the removal site of the graft of the flexor tendons in Anterior Cruciate Ligament Reconstruction	Recruitment completed	Intervention	2023-11-01	<NULL>	<NULL>	6557	Analgesia in Multimodal Infiltration of the donor site of flexor tendons in Anterior Cruciate Ligament Reconstruction	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Clínica de Traumato-Ortopedia do Hospital Naval Marcílio Dias	Clínica de Traumato-Ortopedia do Hospital Naval Marcílio Dias	https://ensaiosclinicos.gov.br/rg/RBR-2g3hpyc	<NULL>	Participants who underwent Anterior Cruciate Reconstruction ACL reconstruction with grafts from the flexor tendons; of both sexes; aged between 18 and 50 years will be included	Patients submitted to revision of Anterior Cruciate Ligament ACL reconstruction, Anterior Cruciate Ligament ACL reconstruction using other grafts; submitted to multiligamentous reconstruction; valgus osteotomy of the tibia or concomitant cartilage repair procedure; allergy to any of the drugs; in chronic use of analgesics; with Body Mass Index BMI above 35 kg/m2 and patients with a history of previous knee surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5gwknk	Analgesia and sedation to guarantee painful venous access in children not intubated.	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4168	Analgesia and sedation for procedures in pediatric patients on spontaneous ventilation: a randomized controlled trial comparing the combination ketamine and dexmedetomidine versus usual care (ASSURE Study)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-13	Hospital Universitario da Universidade de São Paulo	Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5gwknk	<NULL>	To compare the success rates of invasive procedures, such as the insertion of a central venous catheter and peripherally inserted central venous catheter in children on spontaneous ventilation with the use of the combination ketamine and dexmedetomidine versus usual care (habitual sedoanalgesia performed in each of the participating units).	Patients in whom the passage of central venous catheter or peripherally inserted central venous catheter receiving invasive ventilatory care, those receiving sedoanalgesia (except with dipyrone, paracetamol and anti-inflammatory) and those with contraindications to the drugs studied were indicated. Patients who did not have the free and informed consent form signed by their parents or guardians.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-94d594q	Analgesia in Patients with Chronic Knee Pain	Recruitment completed	Intervention	2026-02-09	<NULL>	<NULL>	8839	Assessment of Analgesia Provided by the IPACK Block in Patients with Knee Osteoarthritis: A Randomized, Controlled, Triple-Blind Clinical Trial	<NULL>	2, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-07-01	Programa de Pós-Graduação em Farmacologia	<NULL>	<NULL>	<NULL>	Patients aged between 18 and 80 years, diagnosed with symptomatic knee osteoarthritis refractory to conventional analgesics and with an indication for total knee arthroplasty (TKA), but unable to undergo the procedure either due to clinical contraindications or prolonged waiting times within the Unified Health System, will be included in this study. Furthermore, only patients who voluntarily agree to participate and sign the informed consent form (ICF) will be considered	Patients with mild or asymptomatic osteoarthritis, defined according to the Kellgren Lawrence Criteria, will be excluded from this study; those who undergo follow up at the algology clinic (due to the possibility of multiple interventions that may interfere with the result); those with neurological deficit (sensory or motor) in the limb; those with signs of infection at the puncture site; those with a history of coagulopathies; those with intellectual deficits in responding to the questionnaires applied	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-3x57fj	Analgesic and adjuvant anesthetic effect of tramadol after third molar surgery	data analysis completed	Intervention	2012-05-17	<NULL>	<NULL>	97	Postoperative analgesia and  anesthetic effect of local tramadol chloridrate injection after oral surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-02	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3x57fj	<NULL>	Both gender, above 18 years of age, necessity of removal of inferior impacted third molars, symetric and bilateral	"In use of analgesic or anti-inflammatory drugs before 24 hours treatment, history of seizure, pregnancy, 
lactation, history of psychiatric illness, allergy to the drugs used in this study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-10ntyj94	Analgesic blockade of the nerves responsible for  innervation of the hip for analgesia in the elderly with hip fracture before spinal anesthesia	Data analysis completed	Intervention	2021-06-01	<NULL>	<NULL>	4715	Pericapsular nerve group block preceding spinal anesthesia in elderly people with hip fractures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-16	Insttituto DR José Frota	Insttituto DR José Frota	https://ensaiosclinicos.gov.br/rg/RBR-10ntyj94	<NULL>	over 60 years old age; both genders; physical status ASA II and ASA III; with transtrochanteric;  subtrochanteric;  acetabular and femoral fractures	Hypersensitivity  to any of the drugs used in the study; need to use vasoactive drugs; ventilatory support; decompensated diabetes mellitus; severe arterial hypertension; previous or current coronary artery disease; previous or current stroke; blockade advanced cardiac; severe left ventricular dysfunction; renal or hepatic failure; intracranial hypertension; severe head trauma; glaucoma; psychiatric illness;  illicit drugs users; patients who could not collaborate with the postoperative evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-5vwfqyx	Analgesic effect and muscle activity of Electrical Cortical Stimulation assited by Peripheral Electrical Stimulation in healthy volunteers	Recruitment completed	Intervention	2024-03-18	<NULL>	<NULL>	7185	Effects of Electrical Cortical Stimulation assisted by Peripheral Electrical Stimulation (priming) on ​​activation of descending pain inhibitory pathway and electrical muscle activity in healthy volunteers	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-11-27	Universidade Federal do Delta do Parnaiba-UFDPar	Universidade Federal do Delta do Parnaiba-UFDPar	https://ensaiosclinicos.gov.br/rg/RBR-5vwfqyx	<NULL>	Individuals of both sexes; aged 18 to 35 years; with no history of illnesses or previous surgeries and no complaints of pain (musculoskeletal or visceral)	Chronic pain; concomitant medication that may affect cognitive performance; pregnancy or possible history of pregnancy; drug or alcohol abuse or dependence; recent head injury (within the last 3 months); history of seizure or stroke; neurological; psychiatric diseases and rheumatologic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-48gkx3m	Analgesic effect of the use of Adjuvants in Peripheral Nerve Blocks to minimize Rebound Pain in patients undergoing Shoulder Surgery	Not yet recruiting	Intervention	2022-02-25	<NULL>	<NULL>	5247	Comparative study of the analgesic effectiveness of the uso of Adjuvantes in Peripheral Nerve Blocks to minimize Rebound Pain in patients submitted to Shoulder Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-10	Hospital Universitário do Cajuru - Pontifícia Universidade Católica do Paraná	Hospital de Urgências de Goiânia	https://ensaiosclinicos.gov.br/rg/RBR-48gkx3m	<NULL>	Healthy volunteers; both genders; age above 18 years; physical status classified by the American Society of Anesthesia as I or II	Volunteers with neuropsychiatric disorders, cognitive impairment or mental status changes; users of monoamine oxidase inhibitors or anticonvulsants; with other fractures, injuries or previous surgery on the same operated limb; with paresis or paresthesias of the upper limb of origin different from the main diagnosis; procedures requiring a change in anesthetic technique; volunteers who refuse to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-3fryp7	"Analgesic efficacy of codeine phosphate in combination with paracetamol after
wisdom tooth extractions"	Data analysis completed	Intervention	2020-06-22	<NULL>	<NULL>	3936	"Analgesic efficacy of codeine phosphate in combination with paracetamol after
extractions of impacted lower third molars"	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2013-11-11	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3fryp7	<NULL>	Age between 18 and 50 years; both sexes; no systemic disease or locoregional changes that may affect the tissue repair process or in post-operative sensitivity.	Contraindications of dexamethasone, paracetamol, codeine phosphate and mepivacaine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-9q7j7y	Analysis  of physiotherapy in women who often go to the bathroom	Recruiting	Intervention	2017-06-29	<NULL>	<NULL>	2313	Effect of the physiotherapeutic treatment of surface electrostimulation in the treatment of hyperactive bladder in women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Faculdade de Medicina da Universidade de Brasília-UnB	Faculdade de Medicina da Universidade de Brasília-UnB	https://ensaiosclinicos.gov.br/rg/RBR-9q7j7y	<NULL>	Women between 60 and 80 years old; overactive bladder diagnosis	Stress urinary incontinence; use of overactive bladder medication in the last six months; previous neurological disease; cardiac pacemaker; lower urinary tract infection; vaginal infection; vaginal discharge; vaginal redness; pain on urination; supra-pubic pain; hematuria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-4whyfr4	Analysis and relationship of tooth wear with possible causes in patients with jaw joint problems	Recruitment completed	Observational	2026-01-05	<NULL>	<NULL>	8693	Characterization and correlation of dental wear with possible etiological factors in patients diagnosed with Temporomandibular disorders	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-15	Faculdade de Odontologia da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	The patient must be undergoing treatment in the Orofacial Pain and Temporomandibular Disorder course at Fundecto (FOUSP); be at least 18 years old; either sex	History of oncological treatment in the orofacial region; current use of orthodontic appliances; presence of active caries or symptomatic endodontic treatment; grade 3 tooth mobility; uncontrolled periodontal disease; motor or neurological disorders; significant cognitive or intellectual impairments; wearers of complete dentures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-7rgqkhf	Analysis and validation of leven67 emergency respirator	Not yet recruiting	Observational	2021-01-15	<NULL>	<NULL>	4475	Analysis and validation of light mechanical emergency ventilation equipment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-01-17	ASSOCIAÇÃO BENEFICENTE DE CAMPO GRANDE - Santa Casa de Campo Grande	ASSOCIAÇÃO BENEFICENTE DE CAMPO GRANDE - Santa Casa de Campo Grande	https://ensaiosclinicos.gov.br/rg/RBR-7rgqkhf	<NULL>	Adult patients aged 18 to 80 years; both sexes; adult patients with COVID-19; submitted to tracheal intubation; who await the availability of a conventional ventilator and / or a place in an ICU or Surgical Center bed; in need of tracheal intubation to protect the airways (such as traumatic brain injury); decompensated heart failure; severe pneumonia; without surgery for the next 6 (six) hours	patients under 18 and over 80; indigenous, patients with high doses of vasoactive drugs and hemodynamic instability; polytrauma patients with surgery expected in less than 6 hours; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-76pm35	Analysis by endoscopy in patients with cirrhosis of the liver and varicose veins in the esophagus that are treating osteoporosis with risedronate medicine	Recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1212	Endoscopic analysis of cirrhotic patients with esophageal varices in treating osteoporosis with risedronate	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-19	Fundação de amparo a pesquisa do estado de São Paulo- FAPESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-76pm35	<NULL>	Volunteers with hepatic cirrhosis, esophageal varices and osteoporosis or osteopenia; age greater than 18 years; physical and mental conditions of ingesting medications; agreement to sign the informed consent form.	Severe psychiatric illness; upper gastrointestinal bleeding in the last 6 months; esophageal varices of large caliber; renal insufficiency; active peptic ulcer; esophageal stricture; achalasia; gastroparesis; current use of anti-inflammatories, anticoagulants, platelet anti-aggregants and alcoholic beverage; gestation or lactation; neoplasms of the esophagus, stomach or duodenum; hypersensitivity to bisphosphonates; absolute contraindication to endoscopy; advanced cirrhosis; advanced hepatic encephalopathy; previous liver transplantation; use of hormone replacement therapy; primary hyperparathyroidism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-3nsdfy6	Analysis carried out to verify whether the bandage that fixes the dressings, causes skin allergy	Recruiting	Intervention	2022-01-06	<NULL>	<NULL>	5136	Evaluation of primary irritability potential, accumulated and skin sensitization of a bandage (090997-01) in controlled and maximized conditions (RIPT)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Kors do Brasil Produtos Paramédicos	Kors do Brasil Produtos Paramédicos	https://ensaiosclinicos.gov.br/rg/RBR-3nsdfy6	<NULL>	Agreement to comply with safety guidelines in order to minimize the risks of contamination by COVID 19; healthy subjects; intact skin in the test region; agreement to adhere to the trial procedures and requirements and to attend the institute on the day(s) and time(s) determined for the evaluations; ability to give written consent to their participation in the study; 18 to 59 years old; phototype (Fitzpatrick): I to IV; any gender	Subjects who are to the risk group for COVID 19, i.e., with diabetes; chronic cardiovascular; renal and respiratory disorders; immunosuppressed or other conditions deemed by the physician as belonging to the risk group; pregnant or lactating women; skin marks in the experimental area that interfere with the assessment of possible skin reactions (pigmentation disorders; vascular malformations; scars; increased hairiness; ephelides and nevus in large quantities; sunburn); active (local or disseminated) dermatoses that may interfere with the study results; history of allergic reactions; irritation or intense feelings of discomfort to topical products: cosmetics; health products or medicines; history of atopy (atopic dermatitis; allergic rhinitis; allergic bronchitis; allergic conjunctivitis; etc.); feeling of discomfort with temperature changes (too hot, too cold) and or when using the air conditioning; Subjects with a history of allergy to the materials used in the study; subjects with a known allergy to acrylates; history of pathologies aggravated or triggered by ultraviolet radiation; immunodeficient patients; intense sun exposure or tanning session within 15 days before the initial assessment; predicted intense sun exposure or tanning session during the study period; 11 de 23 MOD_PRO_CEP Rev. 05 All-S-RIPT-SO-PAD-090997-01-06-21-PROF-V01; prediction of bathing in the sea, swimming pool or bathtub during the study; subjects who practice water sports; dermographism; body aesthetic and or dermatological treatment within 03 weeks before enrolment; use of the following medications for topical or systemic use: immunosuppressants; antihistamines; non-hormonal anti-inflammatory drugs and corticosteroids up to 2 weeks before selection or; considering storage corticosteroids; the interval should be 1 month before enrolment; Treatment with acidic vitamin A and or its derivatives; orally or topically; within 01 month before the beginning of the study; predicted vaccination during the study or within 03 weeks before the study; participating or have participated in another clinical study completed less than 07 days before the enrolment, in case the previous study is acceptable in use; participating in or have participated in another clinical study completed less than 21 days ago; if the previous study is a compatibility study or an adverse reaction investigative study; any condition not mentioned above that; in at the investigator&apos;s opinion; may compromise the study evaluation; history of non-adherence or unwillingness to adhere to the study protocol; professionals directly involved in carrying out this protocol and their families	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-5bzbvs	Analysis of 2 drug protocol of dexamethasone in the removal of wisdom tooth	Data analysis completed	Intervention	2020-07-30	<NULL>	<NULL>	4072	Analysis of 2 preemptive periods of dexamethasone in the removal of the third molars. A controlled, randomized, split-mouth, and triple-blind clinical study	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Estudal Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5bzbvs	<NULL>	Young adult patient (18-30 years); Third bilateral molars (upper and lower) with similar positions and angulations evaluated in panoramic; Need for osteotomy and odontostomy for exodontia.	Smolker; Decompensated Metabolic Diseases; Use of medicines that interfere with healing; Periodontal Disease; Inflammation or pathologies associated with third molars.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-2g9ymm	Analysis of a protocol of whole body vibration in the treatment of celullitis	Recruitment completed	Intervention	2017-06-20	<NULL>	<NULL>	1261	Effects of the vibratory platform on the function of pelvic floor muscles and dermatosfunctional dysfunctions in women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade Federal de Alfenas - UNIFAL	Universidade Federal de Alfenas - UNIFAL	https://ensaiosclinicos.gov.br/rg/RBR-2g9ymm	<NULL>	Women; Age from 18 years; Body Mass Index classified as normal or overweight ; Presence of geloid fibroedema in the gluteal region.	Women in dermato-functional body treatment; Women diagnosed with cardiac, neurological and respiratory diseases, diabetes mellitus, systemic arterial hypertension, stone in the kidney or gallbladder, neoplasias and epilepsy; Presence of herniated disc; Use of pacemaker; hip or knee prostheses; Recent pin implants; Plates and screws; Retinal problems; IUD use; Acute inflammation; Acute venous thrombosis; Osteoporosis in advanced stage; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-4h3chsp	Analysis of anti-inflammatory and anti-pain effects of Black Sesame Oil on performance of day-to-day functions and pain intensity in adults with Low Back Pain	Not yet recruiting	Intervention	2023-01-20	<NULL>	<NULL>	5971	Analysis of anti-inflammatory and antinociceptive effects of Subcritical Extract of Black Sesame (Sesamum Indicum L.) on functional performance and pain intensity in adults with Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal do Oeste do Pará	Universidade Federal do Oeste do Pará	https://ensaiosclinicos.gov.br/rg/RBR-4h3chsp	<NULL>	Adults of both sexes; be in the age group between 18 and 55 years; peoples confirmed with the presence of low back pain; present functional impairment and limiting pain due to low back pain; staying one day prior to the start of the study intervention without performing any type of treatment for low back pain; have consent, voluntarily, through the Free and Informed Consent Term (ICF)	"Presence of neoplastic, infectious, neurological, severe progressive orthopedic, rheumatic 
or autoimmune conditions; fibromyalgia diagnosis; presence of decompensated metabolic and/or cardiorespiratory disorders; pregnancy status; obesity; compression fracture of the spine; candidates for neurosurgery or orthopedic surgery; use of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, analgesics, muscle relaxants, psychotropic drugs and/or some other specific treatment for low back pain during the study intervention; previous surgery on the lumbar spine; to present changes in cognitive functions that make it impossible to proceed with the study treatment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-4knsh9z	Analysis of anxiety levels in third molar surgery comparing the use of Zolpidem and Passiflora incarnata: a controlled, randomized, triple-blind clinical study	Terminated	Intervention	2025-03-20	<NULL>	<NULL>	7855	Use of Zolpidem and Passiflora incarnata to control dental anxiety in third molar surgery: a controlled, randomized, triple-blind clinical study	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2021-10-20	Universidade Estadual Paulista Júlio de Mesquita Filho-Unesp	Universidade Estadual Paulista Júlio de Mesquita Filho-Unesp	https://ensaiosclinicos.gov.br/rg/RBR-4knsh9z	<NULL>	Patients in good systemic and local health conditions; both sexe; patients between 16 and 35 years of age; indication of extraction of third molars (elements 18, 28, 38 or 48), with at least 2/3 of the root formed, according to radiographic evaluation, thus belonging to classification I or II and position A or B of Pell and Gregory	Patients who have mandibular third molars in positions 3 and C according to the Pell and Gregory classification; presence of any local manifestations in the area of interest that may contraindicate the surgical procedure, such as: pericoronitis, cysts and odontogenic tumors associated or not with the third molar, trauma in the region, or any symptomatology that indicates the presence of infection; patients who smoke or who have some type of systemic disease (of any organic system), such as diabetes, systemic arterial hypertension, hyperthyroidism, osteoporosis, gastrointestinal diseases that compromise the results of surgery or that contraindicate the administration of the drugs used in the research; patients with a history of hypersensitivity to any drug used in the research; patients who are intolerant to other materials that will be used in the research, such as 0.5% alcoholic chlorhexidine solution, 0.12% chlorhexidine digluconate solution and 2% mepivacaine hydrochloride solution with epinephrine 1:100,000; female patients who are menstruating, gestational or lactating during the period of surgical procedures; patients who have an abnormal sleep pattern, who slept less than 5 hours the night before, or use medication to control psychiatric illnesses, or who are taking medication that interferes with cortisol analyses, such as corticosteroids, estrogens and androgens	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-3hh8kxq	Analysis of bad breath in individuals with bone necrosis in the jaws	Recruiting	Observational	2022-03-27	<NULL>	<NULL>	5307	Analysis of volatile sulfur compounds in individuals with medication-related osteonecrosis of jaws	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-14	Universidade de São Paulo - Campus Bauru	Universidade de São Paulo - Campus Bauru	https://ensaiosclinicos.gov.br/rg/RBR-3hh8kxq	<NULL>	Individuals over 18 years of age with a confirmed diagnosis of medication; related osteonecrosis of the Jaw according to clinical and imaging criteria according to the American Association of Oral and Maxillofacial Surgeons Annual Meeting; who are being monitored at the Clinical Research Center University of São Paulo Bauru	History of head and neck cancer and undergoing radiotherapy in the head and neck region; current diagnosis of infection in the upper and or lower respiratory tract; gastric reflux; pregnancy; lactation; liver failure; individuals undergoing hemodialysis; individuals with a history of diseases that may pose a risk to themselves or to the evaluator such as sarcoidosis tuberculosis severe heart disease drug or alcohol abuse graft versus host disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-5q5g4s6	Analysis of biceps and triceps brachii muscle activity during elbow flexion and extension movements using Pilates breathing with different loads: a clinical trial	Not yet recruiting	Intervention	2024-04-10	<NULL>	<NULL>	6929	Electromyographic analysis of the biceps and triceps brachii muscles during elbow flexion and extension movements using the Pilates method breathing technique in different load settings: a clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5q5g4s6	<NULL>	Participants must be healthy individuals of both sexes; aged between 18 and 25 years; with no experience with the Pilates method	Participants who do not sign the informed consent form; who cannot attend a second data collection session; who are unable to perform the Pilates method technique; who cannot remain in an upright position; who are unable to perform flexion and extension movements of the curves; who have undergone surgical procedures that prevent the protocol from being performed; who have recent injuries in the elbow region; who show signs and symptoms of inflammation; who have a high degree of muscle imbalance between the upper limbs; who have serious neurological, cardiorespiratory, or metabolic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-38x665	Analysis of biological blood markers after computer-based memory stimulation in adults over 45 years old attended at the memory clinic	Data analysis completed	Intervention	2020-03-16	<NULL>	<NULL>	3618	Analysis of serums neurobiomarkers  after cognitive stimulation using technology in adults over 45 years old at the Memory Clinic	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-24	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-38x665	<NULL>	Adults and elderly aged between 45 and 80 years old; assisted by the Unified Health System at the Memory Clinic at the UNISUL; Cognitive assessment performed by MoCA with a score above 12.	Individuals with dementia or with visual impairment or physical/mental condition that disallow to move at the University and attending an intervention using a desktop computer with internet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-9f7fpw	Analysis of body balance and muscle activity before and after reconstruction of the anterior cruciate ligament (acl)	Recruitment completed	Intervention	2016-05-30	<NULL>	<NULL>	913	Analysis of body oscillation and myoelectric activity before and after reconstruction of ACL (anterior cruciate ligament)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-23	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9f7fpw	<NULL>	"Complete unilateral ACL injury (anterior drawer and Lachman + MRI); 
Prediction of surgical reconstruction and have no other clinical finding of dysfunction or injury in the affected limb; 
Do not submit ligament or joint injury in the lower limb or contralateral vestibular and / or neurological dysfunction."	Failure to attend one of the reviews; Interruption of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-5zsjrd	Analysis of body mass index (BMI) and diet of adults with Down syndrome and their caregivers in the process of nutritional guidance	Recruiting	Intervention	2020-04-24	<NULL>	<NULL>	3772	Analysis of the nutritional status and eating habits of adults with DOWN SYNDROME and their main caregivers in the process of health education and nutritional intervention	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-03	Faculdade de medicina da USP	Faculdade de medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-5zsjrd	<NULL>	Adult volunteers with down syndrome and their primary caregiver; both genders; aged between 19 and under 35.	Volunteers with ostomies, Hirschsprung&apos;s disease, severe intellectual disability, decompensated heart disease, food allergies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-3xhsjx	Analysis of Body Temperature and Energy Spending during Aerobic Training with and without Blood Flow Restriction  in physically active subjects	Recruitment completed	Intervention	2017-08-29	<NULL>	<NULL>	1356	Analysis of the Thermographic Standard and Energy Expendutire during Aerobic Training with and without Blood Flow Restriction  in physically active subjects: a controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal da Paraíba - UFPB	Universidade Federal da Paraíba - UFPB	https://ensaiosclinicos.gov.br/rg/RBR-3xhsjx	<NULL>	Young adults physically active; No presence or history of osteoarticular or muscular diseases in the lower limbs; That respond negatively to the Physical Activity Readiness Questionnaire; They present Brachial Ankle Index between 0.91 and 1.30; Physically active.	Missing one of the evaluations; If injured during the study; Can not adapt to the training proposed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-9dx9g7	Analysis of bone loss around implants subjected to immediate occlusal loading and late occlusal loading	Recruitment completed	Intervention	2019-09-24	<NULL>	<NULL>	2991	Radiographic and microbiological evaluation of periimplant bone surface. Clinical study comparing Immediate-Loaded Implants and Late-Loaded Implants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-9dx9g7	<NULL>	Inclusion criteria were patients with single or múltipla; unilateral or bilateral losses of molars or lower premolars; with age above 18 years of both sexes; non-smokers; free of systemic problem;, with good oral health status and did not require previous bone reconstruction.	The exclusion criterion was the patients who did not agree to participate in the study and did not fulfill the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-7g7rq3	Analysis of cardiac and respiratory components after walking exercise in patients who suffered a stroke	Data analysis completed	Intervention	2019-08-20	<NULL>	<NULL>	2882	Cardiac Variability in Aerobic and Resistant Training of patients with Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-15	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7g7rq3	<NULL>	Patients between the ages of 40 and 65 years; verification of the stroke by image examination and medical report; injury time over one year; acceptance in participating in the intervention	Patients who could not walk or clinical conditions for walking; other neurological diseases; did not have medical clearance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-5nr9xq	Analysis of cervical posture and analyze the muscles of the shoulder and upper back for individuals who may use upper and lower dentures	Recruitment completed	Intervention	2013-07-08	<NULL>	<NULL>	209	Analysis of electromyography and craniocervical posture of patients with denture bimaxillary	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-08-08	Universidade Federal Alfenas	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5nr9xq	<NULL>	Individuals referred for fitting total bimaxillary older than 40 years, who agree to sign an Informed Consent	Individuals under the age of 39 years, patients with cancer who do not agree to sign an informed consent. Dentofacial deformity, trauma in the head and neck. Individuals who take muscle relaxant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-5z6nbkh	Analysis of changes in peri-implant tissues in rehabilitated patients with inferior protocol-like prosthesis versus inferior over-denture prosthesis.	Recruiting	Intervention	2021-07-29	<NULL>	<NULL>	4804	"Implant / mucus rehabilitation supported in total edentulous patients. Analysis of
parameters reported by the patient and the clinical, microbiological and osteoimmunoinflammatory impact
in peri-implant tissues."	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-23	universidade paulista	universidade paulista	https://ensaiosclinicos.gov.br/rg/RBR-5z6nbkh	<NULL>	Thirty individuals, total male or female, will be selected, with a minimum age of 40 and a maximum age of 80 years, with an indication for mandibular rehabilitation.	smoking, pregnant, lactating, obese individuals, as well as those with systemic diseases (osteoporosis, immunological disorders, hepatitis, diabetes mellitus, etc.) will be excluded. Use of corticosteroids, non-steroidal anti-inflammatory drugs, immunosuppressive drugs, estrogen and modulators of estrogen, alendronate and calcitonin receptors during the 6 months prior to the study will also be considered exclusion factors. Subjects who do not have enough bone tissue for the placement of dental implants and who require additional surgical procedures before or during their installation will also be excluded. Individuals with a history of bone grafts at sites indicated for implant placement will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-7zwzs3	Analysis of Cinnamaldehyde to be used in the Treatment of Fungal Infection due to the use of dental prostheses	Not yet recruiting	Observational	2019-09-03	<NULL>	<NULL>	2924	Efficacy and Safety of Cinnamaldehyde in the Treatment of Buccal Candidiasis associated with the use of dental prostheses: Clinical Trial, Randomized, Controlled and Blind	<NULL>	1-2, randomized-controlled, triple-blind	1-2	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7zwzs3	<NULL>	"Fase I: The study will include healthy individuals and users of upper removable total prosthesis, belonging to the age group from 40 to 70 years.
In order for there to be no confusion of signs and symptoms relevant to possible adverse effects of the test product with signs and symptoms of disease, healthy subjects were selected as defined by the Phase I clinical trial definition.
fase II: Individuals belonging to the age group from 40 to 70 years old, with oral candidiasis and dental prosthesis user, with a signed and signed Free and Informed Consent Term."	Fases I e II: Individuals undergoing topical and / or systemic antimicrobial treatment and who have a sensitivity reaction to cinnamaldehyde, cinnamon or Miconazole.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-66gdhfm	Analysis of clinical and laboratory variables to create a score for the indication of invasive mechanical ventilation in patients with COVID-19	Recruitment completed	Observational	2024-09-20	<NULL>	<NULL>	7360	Analysis of clinical and laboratory variables to create a score for indicating invasive mechanical ventilation in patients with suspected and/or confirmed covid-19	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-03-01	Hospital Universitário Pedro Ernesto	Hospital universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-66gdhfm	<NULL>	The inclusion criteria will be individuals with suspected or clinical diagnosis of COVID-19, with a minimum hospital stay of 24 hours and submitted to oxygen therapy or non-invasive ventilation. The research protocol will be in accordance with Resolution 466/12 and will be forwarded to the Ethics and Research Committee of HUPE - CEPq, via Plataforma Brasil, and all research participants will sign the Free and Informed Consent Term and the Commitment Term of data usage.	Exclusion criteria for participation in the study will be as follows: (1) patients under 18 years of age; (2) patients with a negative laboratory test for COVID-19; (3) patients requiring emergency intubation; (4) patients who underwent previous endotracheal intubation in the same hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-35td3p	Analysis of clinical and radiological factors in Viscosupplementation treatment (Hyaluronic Acid + Sorbitol) in patients with knee Arthrosis: prospective cohort study	Recruiting	Observational	2020-11-20	<NULL>	<NULL>	4380	Analysis of clinical and radiological factors as predictors of response to Viscosupplementation (Hyaluronic Acid + Sorbitol) in patients with knee Osteoarthritis: prospective cohort study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de São Paulo	Ortocity	https://ensaiosclinicos.gov.br/rg/RBR-35td3p	<NULL>	"Osteoarthritis grade 1 to 4 Kellgren and Lawrence. 
Magnetic resonance Imaging of the knee 1.5 T performed up to 3 months before viscosupplementation.
Failure of conservative treatment for knee osteoarthrosis: pain &gt; 5 on Visual Analogue Scale on walk after 30 days of performed  standardized physiotherapy 10 sessions and simple analgesia."	"Magnetic resonance imaging with insufficient protocol or inadequate technique. Radiographies with inadequate technique.

Non-inclusion criteria:
Systemic inflammatory disease;
Diagnosis of other orthopedic conditions in the affected lower limb;
Viscossupplementation or other infiltration in the affected knee performed up to 12 months prior to the study;
Corticosteroids in the last 6 months; 
History of previous allergy to Hyaluronic acid or Sorbitol;
Pregnant;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-6fhv7x5	Analysis of clinical, humanistic and economic outcomes of patients with anxiety using herbal medicines	Not yet recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6387	Analysis of clinical, humanistic and economic outcomes of patients with anxiety using Passiflora sp.	<NULL>	4, n/a, n/a	4	<NULL>	<NULL>	<NULL>	2023-10-15	Universidade Federal de Alfenas- MG	Universidade Federal de Alfenas- MG	https://ensaiosclinicos.gov.br/rg/RBR-6fhv7x5	<NULL>	The study population will consist of people aged ≥ 18 years, without gender restriction, who sought pharmaceutical care at a university pharmacy with a main complaint of anxiety or symptoms that characterize anxiety.	Patients who do not adhere for any reason to the treatment with the proposed herbal medicine during the three months of follow-up in this study will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-5bphrt	Analysis of dental biofilm&apos;s proteins and its relation with the effectiveness of the resin infiltration technique to prevent tooth breakdown in children who present molar-incisor hypomineralization (MIH)	Recruiting	Intervention	2017-09-22	<NULL>	<NULL>	1399	Proteomal analysis of dental biofilm and its association with the effectiveness of the resin infiltration technique for the prevention of post-eruptive breakdown in children with molar-incisor hypomineralization (MIH)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-03	Faculdade de Ciências da Saúde - Universidade de Brasília	Secretaria de Educação do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-5bphrt	<NULL>	Children with 8 years old; with good general health; with the first four permanent molars erupted, with at least one being affected by molar-incisive hypomineralization (MIH); who sign the terms of assent; whose parents have signed the TCLEs.	Children who have used any antifungal drug therapy or topical oropharyngeal antimicrobial medications for at least three months prior to collection; children outside the established age range; children with systemic, motor or psychological impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-2z73q5	Analysis of different recovery methods after fatigue	Recruitment completed	Intervention	2020-07-08	<NULL>	<NULL>	4398	Influence of different post-exercise recovery methods on neuromotor performance in amateur sportsmen	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Fundação Universidade Federal de Mato Grosso do Sul	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2z73q5	<NULL>	Healthy male men; 15 to 30 years-old; being sportsmen to at least one year.	Recent onset of musculoskeletal injuries;Raynaud&apos;s disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-8s5cbfk	Analysis of different sealers used in root canal treatment on postoperative pain in endodontics.	Recruiting	Intervention	2022-03-08	<NULL>	<NULL>	5265	Effect of calcium silicate-based sealer and epoxic resin-based sealer on post-operative pain in endodontics: a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8s5cbfk	<NULL>	Men and women aged 18–65 years, diagnosed with symptomatic irreversible pulpitis with indication for endodontic treatment in permanent molar teeth, will be included in the study, confirmed by positive response to clinical, cold vitality and radiographic tests. The individual who participates in this research must have a contact number (phone or cell phone) to be able to carry out the post-operative evaluations.	Patients who were pregnant, immunocompromised, on medication or hypersensitive to anti-inflammatory drugs, or patients with occlusal disorders or any type of periodontitis or endodontic complications were excluded from the study, since these conditions would interfere with the analysis of the presence of pain after endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-69mywb5	Analysis of Dog-Assisted Physiotherapy for children with Cerebral Palsy	Recruitment completed	Intervention	2023-05-25	<NULL>	<NULL>	6105	Dog-Assisted Physiotherapy: structured complementary physiotherapeutic intervention in children with Cerebral Palsy: a single-subject design	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Departamento de Ciências do Movimento Humano - Universidade Federal de São Paulo	Unifesp - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-69mywb5	<NULL>	Children diagnosed with Cerebral Palsy with unilateral or bilateral involvement; both genders; age between 6 and 10 years; classified by the Gross Motor Function Classification System - GMFCS, at levels II or III; having already had contact with dogs in the home, family, friends or neighborhood; being part of a physiotherapy service; do not have surgeries scheduled for the six months following the beginning of the research	Two consecutive or alternating fouls per phase; signs of aversion to the dog or the therapy; dog allergy signs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-9t48g5	Analysis of fatigue and immune response in patients with and without cancer treated with video game	Recruiting	Intervention	2015-04-16	<NULL>	<NULL>	450	Analysis of fatigue and immune response cells in cancer patients treated with exergames Randomized and controlled clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Fisioterapia da Universidade Federal de Alfenas	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9t48g5	<NULL>	"Control group: Healthy individuals; both sexes; aged between 18 and 80 years.
Experimental group: individuals with cancer;  both sexes; aged between 18 and 80 years; chemotherapy; radiotherapy; after surgery with medical clearance for physical activity."	Cognitive disorders that hinder the explanation of the handling of virtual environments; serious infectious diseases; disabling diseases in upper and lower limbs; patients with myopathies; diseases with recognized change of collagen; with neurological diseases; for personal reasons do not wish to participate; previous contact with exergames.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-10cr49dr	Analysis of foraminal patency attainment rates by undergraduate students - An &quot;in vivo&quot; Study	Data analysis completed	Intervention	2021-12-13	<NULL>	<NULL>	5100	Analysis of foraminal patency attainment rates by undergraduate students - An &quot;in vivo&quot; Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-12	Universidade Paranaense	Universidade Paranaense	https://ensaiosclinicos.gov.br/rg/RBR-10cr49dr	<NULL>	Patients with one or more dental elements indicated for radical endodontic treatment; complete rhizogenesis	Dental elements with previously performed endodontic treatments; root curvatures; root resorption processes; anatomical complexities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-4d6n9r	Analysis of genetic information from men with and without varicocele	Not yet recruiting	Observational	2016-03-18	<NULL>	<NULL>	758	Sperm transcriptome profile in men with and without varicocele	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Faculdade de Medicina de Ribeirão Preto	Centro Regional de Hemoterapia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4d6n9r	<NULL>	"Study group: men that have varicocele in grades II and III; aged between 18 and 45 years; not having done previous surgery correction of the disease.
Control groups: men aged between 18 and 45 years; fertility proven by having at least two children; and selected men from couples with infertility for male factor or unexplained infertility."	Smoking; excessive use of alcohol; drug abuse; genetic damage; prior varicocele correction surgery; testicular trauma; urogenital infections suspicion; cancer; endocrinopathies; treatments that may influence the testicular functions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-67jth2z	Analysis of genetic molecules and cells for Tuberculosis identification and prediction	Recruiting	Observational	2023-10-09	<NULL>	<NULL>	6494	Evaluation of molecular and cellular markers for Tuberculosis diagnosis and prognosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-13	Instituto Gonçalo Moniz (IGM) da Fundação Oswaldo Cruz (FIOCRUZ)	Instituto Gonçalo Moniz (IGM) da Fundação Oswaldo Cruz (FIOCRUZ)	https://ensaiosclinicos.gov.br/rg/RBR-67jth2z	<NULL>	Participants with respiratory symptoms; men and women aged between 18 and 65 years (including) at the moment of informed consent; respiratory symptoms as a reason for seeking assistance at the Octávio Mangabeira Specialized Hospital (HEOM). Healthy participants; men and women aged between 18 and 65 years (inclusive) at the time of informed consent; postgraduate students, technicians, and/or researchers from the Gonçalo Moniz Institute (IGM), Fiocruz-Ba; absence of respiratory symptoms or acute illnesses in the last 14 days.	Participants with respiratory symptoms; individuals under 18 years old and over 65 years old; using systemic corticosteroids; who have had a previous diagnosis and/or treatment for pulmonary TB in the last two years; transplant recipients, undergoing cancer treatment, or having autoimmune diseases. Healthy participants; presence of respiratory symptoms or acute illnesses in the last 14 days; previous diagnosis and/or treatment for pulmonary TB in the last two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-5ct5f9w	Analysis of Gingival Healing Bordering Prosthetic Abutments with Treated Surface	Recruitment completed	Intervention	2024-12-06	<NULL>	<NULL>	7576	Histological and Histomorphometric Analysis of Gingival Healing at the Interface of Prosthetic Abutments treated with Anodization	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-5ct5f9w	<NULL>	Patients of both sexes; partial edentulousness in the posterior maxilla; with absence of at least two teeth, whether contiguous or not; healed ridges that do not require tissue evacuation for subsequent implant installation; implants installed with primary stability; mucosal thickness on the ridge crest minimum of 2 mm in height of the keratinized tissue	Patients who require some type of advanced bone or surgical assistance to allow implant installation; with systemic contraindication to the surgical procedure or conditions that interfere with the osseointegration process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-2hmgr4d	Analysis of gum substances in patients who underwent Home Teeth Whitening	Recruitment completed	Intervention	2025-07-24	<NULL>	<NULL>	8153	Analysis of acute phase markers in patients undergoing at-Home Dental Bleaching:a blinded randomized controlled clinical trial	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2025-05-06	Universidade de Brasilia/ Departamento de odontologia	Universidade de Brasilia/ Departamento de odontologia	https://ensaiosclinicos.gov.br/rg/RBR-2hmgr4d	<NULL>	Patients aged between 18 and 40; both sexes; healthy; without active caries or periodontal disease and interested in whitening their teeth will be selected	Use of antimicrobials and immunosuppressants for less than three months; smokers; hospitalization and dental treatment within three months prior to the start of the study; pregnant and breastfeeding women; patients with unsatisfactory restorations; severe fluorosis; tetracycline staining	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-58j2jmh	Analysis of heart rate in people with spinal cord injury using two types of arm bicycles and physical tests and its relationship with general health. A controlled study	Not yet recruiting	Intervention	2025-03-26	<NULL>	<NULL>	7866	Analysis of heart rate variability between two types of Cycle ergometers and between functional submaximal tests and their correlation with health status in individuals with spinal cord injury - Randomized controlled clinical trial - Phase I	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Departamento de Fisioterapia da Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-58j2jmh	<NULL>	Volunteers with spinal cord injury; both genders; aged between 18 and 50; neurological levels below the 6th spinal cord segment; complete or incomplete spinal cord injury; more than 6 months since injury; no regular physical activity; no physiotherapy	Volunteers with other associated neurological diseases; history of heart disease or lung disease; diagnostic hypothesis; who are unable to complete the tests for any reason such as withdrawal, hospitalization, infections, dermal, musculoskeletal, vascular or respiratory complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-4brjtqz	Analysis of heart rate variability and effort in children and young people with Down syndrome in the use of virtual games for home telerehabilitation	Recruitment completed	Intervention	2022-01-28	<NULL>	<NULL>	5185	Analysis of heart rate variability and perception of physical effort in children and young people with Down Syndrome submitted to virtual games protocol by home telerehabilitation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-04	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4brjtqz	<NULL>	Participants were included if they were children and adults with DS aged 10 to 30 years old; agreed to participate in the research from themselves (by signing assent form ) and their legal guardians (by signing a consent form).	Participants were excluded if they were unable to understand and execute the specific guidelines and commands of the intervention; did not adapted to the proposed intervention protocol; or those that presented technical failure in the technological devices preventing the realization of the protocol. Children and young adults who presented low vision or blindness, vestibular pathologies and those who did not had technological devices to perform telerehabilitation were not included in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-10s8qxy8	Analysis of implants with different designs over 10 years of follow-up	Recruitment completed	Intervention	2025-12-22	<NULL>	<NULL>	8674	Analysis of the microbiome and proteomics of peri-implant crevicular fluid associated with healthy and peri-implantitis-affected implants, comparing different implant designs - A randomized, controlled, double-blind trial in a split-mouth model with 10-year follow-up	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2012-02-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Clinically healthy patients; Both genders; Age between 18 to 70; Completely edentulous patients; Dental extractions performed more than 6 months previously	Patients with alcohol, drug or medication abuse; Smokers or those with systemic diseases, such as uncontrolled diabetes; Coagulation disorders; Severe cardiac vascular disorders and other significant illnesses	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-99c9hxc	Analysis of inflammation in patients with diseases around dental implants before and after treatment	Recruiting	Intervention	2025-08-18	<NULL>	<NULL>	8215	Evaluation of cytokine expression in patients with Mucositis and Peri-implantitis before and after treatment	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-05	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-99c9hxc	<NULL>	Individuals over 18 years of age; both genders; non-smokers; systemically healthy or medically controlled; partially edentulous, with at least two osseointegrated implants presenting peri-implant disease (peri-implant mucositis or peri-implantitis); with implant-supported prostheses in function for at least six months	Individuals who received periodontal or peri-implant treatment up to six months prior to the start of the study; pregnant or breastfeeding patients; smokers; individuals who used antibiotics and/or anti-inflammatory drugs in the past three months; those who used antiresorptive medications in the past two years; or who underwent radiotherapy, chemotherapy, or iodine therapy in the past two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-863c6dk	Analysis of injuries and physical conditioning in amateur athletes and development of a preventive protocol	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7181	Analysis of the prevalence of injuries and cardiorespiratory fitness in amateur athletes and development of a preventive protocol	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-14	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-863c6dk	<NULL>	Both sexes; aged over 13; literate; that practice beach tennis and/or football at least once a week; capable of carrying out the proposed exercises and who agree to participate in the research by signing the Informed Assent Form (TAE) for underage participants and also; signature of their legal guardians on the Free and Informed Consent Form (TCLE). For participants over 18 years of age, agreement and signature of the Free and Informed Consent Form (TCLE)	Lack of autonomy (permanent or temporary); underlying cardiovascular disease in the last 24 months; such as acute myocardial infarction; angina; stroke or heart failure; body mass index (BMI) &gt;39.9 kg/m²; proliferative diabetic retinopathy or have a health problem that makes them unable to continue carrying out the planned protocols or suggested intervention, interrupt the practice during the research or abandon the study for personal reasons	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-9xzsyx	Analysis of Intellectual Capabilities in People with Multiple Sclerosis in Virtual Games	Recruiting	Observational	2019-11-18	<NULL>	<NULL>	3193	Analysis of Cognitive Functions in people with Multiple Sclerosis in Virtual Activities	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-06-22	Universidade de São Paulo	Associação Brasileira de Esclerose Multipla	https://ensaiosclinicos.gov.br/rg/RBR-9xzsyx	<NULL>	All patients under clinical follow-up for Multiple Sclerosis will be considered eligible in the Brazilian Multiple Sclerosis Association.	Patients with visual impairment; with motor deficits that prevent them from performing the task; with presence of fatigue; with deformity or muscle weakness in the upper limbs; who have had an outbreak in the last month; performing surgery; chemical neuromuscular blockage in the upper limbs in the last six months prior to study participation; who are unable to perform the task in a single attempt with the verbal instructions and demonstrations provided	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-79h2ppx	Analysis of intestinal mucosa and fat nearby the intestine in patients with Crohn&apos;s disease	Data analysis completed	Observational	2023-07-05	<NULL>	<NULL>	6203	Transcriptional analysis of intestinal mucosa and mesenteric adipose tissue of patients with Crohn&apos;s disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-10-25	Hospital de Clínicas - Universidade Estadual de Campinas (UNICAMP)	Hospital de Clínicas - Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-79h2ppx	<NULL>	Patients with endoscopic and histological diagnosis of ileocecal Crohn&apos;s disease undergoing surgical procedure. For the control group of distal ileum, patients who underwent colonoscopy for other reasons, whose examination comes without endoscopic changes. For the control group of mesenteric adipose tissue (intestinal fat), patients with non inflammatory diseases of the left colon undergoing surgery, with normal terminal ileum. All survey participants are over 18 years of age	The patients participating in the control groups without the use of medication. And Crohn&apos;s patients with disease locations other than the small intestine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-6s72rf	Analysis of intrastromal corneal ring implants in irregular corneas at a reference center in Brazil	Data analysis completed	Observational	2016-05-23	<NULL>	<NULL>	860	Analysis of intrastromal corneal ring implants in ectatic corneas or presenting secondary irregular astigmatism in a reference center in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-09-20	Universidade Federal de São Paulo - Departamento de Oftalmologia	Taíse Tognon	https://ensaiosclinicos.gov.br/rg/RBR-6s72rf	<NULL>	"All patients who underwent intrastromal corneal ring implantation between November 2009 and December 2012 in Sorocaba Ophthalmological Hospital.
Surgical technique exclusively manual or using fentosecond LASER assistance.
Patients whose implants used were Kerarings of 5mm diameter."	"Incomplete medical records.
Incomplete ophthalmic preoperative evaluation or incomplete preoperative complementary exames (for example previous corneal topography or tomography and pachymetry)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2vkjzp	Analysis of jaws position in orthognathic surgery using zygomatic supported guides	Not yet recruiting	Intervention	2020-01-20	<NULL>	<NULL>	3383	Accuracy analysis of jaws position in orthognathic surgery using intermediate guides supported on zygomatic bones	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-02-10	Obras Sociais Irmã Dulce	Obras Sociais Irmã Dulce	https://ensaiosclinicos.gov.br/rg/RBR-2vkjzp	<NULL>	Individuals over than 18 years; without comorbidities; with facial deformities; with indication for maxillomandibular surgery for correction	Individuals requiring isolated surgery of the maxilla or mandible;individuals with diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-5cyj66b	Analysis of laser acupuncture in children and adolescents undergoing chemotherapy.	Recruitment completed	Intervention	2022-01-11	<NULL>	<NULL>	5143	Analysis of laser puncture in the improvement of symptoms of pain, fatigue and nausea in children and adolescents with cancer.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-5cyj66b	<NULL>	Be between 8 and 15 years of age; clinical diagnosis of cancer, being undergoing chemotherapy within the time of the research (the participant may be receiving chemotherapy or during the same period), being hospitalized in the oncology unit of HIJG (Joana de Gusmão Children&apos;s Hospital), having received the diagnosis of cancer for at least 10 days.	Parents or responsible medical staff do not accept participation in the research; children or adolescents admitted to the ICU with end-stage cancer or an inconclusive clinical diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-63xvgf	Analysis of low level laser therapy in the treatment of patients with fibromyalgia	data analysis completed	Intervention	2012-05-10	<NULL>	<NULL>	134	Analysis of low level laser therapy in the treatment of patients with fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade do Vale do Paraíba - UNIVAP	https://ensaiosclinicos.gov.br/rg/RBR-63xvgf	<NULL>	"Clinical diagnosis of fibromyalgia;
Age between 20 and 80 years;
Signing the consent form;"	Don´t have	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7w84sz	Analysis of lumbar spine movement with mobilization and with digit pressure	Recruiting	Intervention	2019-10-11	<NULL>	<NULL>	3077	Analysis of lumbar spine movement mobilization versus pressure movement mobilization	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7w84sz	<NULL>	Healthy male volunteers aged 18 to 30 years.	Women; male under 18 and over 30 years old; medical diagnosis of neurological diseases; orthopedic; traumatological; rheumatologic diseases that promote changes in static balance or cause chronic pain; uncontrolled arterial hypertension and cutaneous lesions in the lumbar spine / lower limbs that might prevent data collection and / or interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-4fxqw5	Analysis of memories about injuries in the football in adolescents	Data analysis completed	Observational	2015-07-09	<NULL>	<NULL>	539	Analysis of recall bias information about injuries in the football  in adolescents	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-07-30	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4fxqw5	<NULL>	Aged 12 and 18 years; male gender; they make effective portion of the sports season (this year).	Inability to practice sports physical activity in the past six months; refuse to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-2kpz5j	Analysis of microorganisms existing in denture wearers before and after the use of two adhesives	Not yet recruiting	Intervention	2015-08-17	<NULL>	<NULL>	587	Oral microbiota analysis of conventional complete dentures wearers before and after the use of two adhesives	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Estadual Paulista - UNESP	CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2kpz5j	<NULL>	Adult individuals; receptive and mentally agile; good understanding of spoken Portuguese; with availability to attend evaluations during the experimental phase; alveolar ridges with normal resilience and volume	Systemic debilitations; use of antibiotics at the moment of inclusion in the study and for 3 months prior to the first assessment or sample collection; previous use of denture adhesives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-9qvwvyw	Analysis of morse taper implants installed at the bone level and 2 mm above bone followed by the installation of crowns printed in hybrid resin	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5179	Analysis of morse taper implants installed at the bone level and 2 mm subcrestally followed by the installation of crowns printed in hybrid resin. clinical, controlled, randomized study with split-mouth model	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9qvwvyw	<NULL>	Age between 18 and 60 years, need for bilateral unitary rehabilitation with osseointegrated implants in the maxilla or mandible, sufficient bone availability to install a conventional size implant, good systemic health	Smokers and former smokers, diabetics, chronic drug users (eg. Bisphosphonates, Immunosuppressants, anti-inflammatory drugs) or pathologies that alter bone metabolism (eg. Osteoporosis; Diabetes), patients who chronically use anti-inflammatory drugs and antibiotics, people with bruxism, alcoholics, drug addicts, pregnant or wishing to become pregnant in the next year, history of radiotherapy treatment in the head and neck region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-8b6b9r	Analysis of motor learning in people after stroke through computer games	Recruitment completed	Intervention	2020-09-18	<NULL>	<NULL>	5147	Analysis of Motor Learning of the upper limbs after intervention with Non-Immersive Virtual Reality in individuals after stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Escola de Artes,Ciências e Humanidades da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8b6b9r	<NULL>	Adults and the elderly between 40 and 75 years old, with sequelae of Stroke at least two months after injury and adequate mental and cognitive function, verified by the Mini Mental State Examination (MMSE).	The existence of visual changes; deformities; recent neuromuscular unblocking (last six months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4kf52bv	Analysis of motor performance after performing Telerehabilitation with virtual reality games in people with Cerebral Palsy	Recruitment completed	Intervention	2023-11-21	<NULL>	<NULL>	6596	Analysis of motor performance after performing Telerehabilitation with virtual reality games in people with Cerebral Palsy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-01-19	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4kf52bv	<NULL>	Clinical diagnosis of Cerebral Palsy; classified in Gross Motor Function (GMFCS) between levels I to V; classified in Manual Function (MACS) between levels I to V; age ranging from 5 to 40 years, of any muscle tone	Those who do not understand the tasks of the game; have motor difficulties that prevent the performance of virtual tasks; surgery or use of an upper limb spasticity inhibitor during the last six months; do not have technology devices to perform telerehabilitation; impediment of complete the task due to some technological glitch	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-2fvw6v	Analysis of motor response time, electromyography and muscle strength in diabetic volunteers after home exercise: randomized, controlled, cross-over clinical trial	Recruitment completed	Intervention	2020-11-16	<NULL>	<NULL>	7208	Analysis of feedforward, electromyography and muscle strength in volunteers from the Covid-19 risk group undergoing a home exercise protocol: randomized, controlled, cross-over clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-05	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2fvw6v	<NULL>	Individuals diagnosed with type II Diabetes Mellitus, according to the criteria of the American Diabetes Association; between 20 and 90 years of age; both sexes; undergoing diet therapy or oral antidiabetics and signing the free and informed consent form	Individuals with type II Diabetes Mellitus at very high risk, that is, those with ulcers and/or previous amputations; clinical diagnosis of hemiplegia; paraplegia; or Parkinson&apos;s disease; limb amputation; a history of alcohol or drugs; herniated disc; leprosy; severe arthritis that prevents walking; insanity; intellectual disability; and other psychiatric disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3dtzdb	Analysis of movement and muscle activity of the balance of strategies used by children with spastic cerebral palsy during the pediatric previous range test	Recruitment completed	Intervention	2015-09-21	<NULL>	<NULL>	621	Kinematic and electromyographic analysis of the equilibrium strategies used by children with spastic cerebral palsy in the pediatric reach test	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3dtzdb	<NULL>	"The inclusion criteria for the CPG (Cerebral Palsy Group) will be the diagnosis of cerebral palsy; grade mild or moderate; diparesis type; grade I (without walking restrictions, limitations in the more advanced gross motor skills) and II (walk without assistive devices, with limitations in space open and community) according to the GMFCS (Gross Motor Function Classification System).
For CG (Control Group), the inclusion criteria established will be the absence of any motor; perceptual; sensory and cognitive commitment."	"Exclusion criteria for the CPG (Cerebral Palsy Group) will be considered the presence deformity in the lower limbs or spine that compromises stay in the upright posture and cognitive changes that undermine the understanding of the tasks performed during avaliação.
For the CG (Control Group), exclusion criteria will be the diagnose of any malformations; genetic syndromes; congenital defects; deformities
postural or other changes that may bring harm to the neuromotor; cognitive and emotional development of the child.
For both groups, be an exclusion criterion the presence of respiratory symptoms or respiratory disease with prior interval of one month of evaluation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-23frm8c	Analysis of new measurement of Peripherally Inserted Central Catheter in neonates	Recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6348	Efficacy of a new method for Peripherally Inserted Central Catheter placement in neonates in relation to the location of the device tip: a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-02-03	Universidade Federal Fluminense	Programa de Pós-Graduação Mestrado Profissional em Enfermagem Assistencial	https://ensaiosclinicos.gov.br/rg/RBR-23frm8c	<NULL>	Peripherally inserted central catheter procedures in upper limbs; term newborns; preterm newborns; both sexes	Puncture site for catheter insertion other than in the upper limbs; insertion procedure performed in newborns with congenital anomalies of the venous network; newborns with coagulopathies; malformation in upper limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-96n5x69	Analysis of osseointegration of implants with different macrogeometries: a randomized clinical trial	Data analysis completed	Intervention	2023-06-19	<NULL>	<NULL>	6158	Analysis of osseointegration of implants with a new macrogeometry: randomized clinical trial in split mouth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-07	pontifícia universidade católica do paraná	pontifícia universidade católica do paraná	https://ensaiosclinicos.gov.br/rg/RBR-96n5x69	<NULL>	partial edentulous patients in the posterior region of the mandible requiring one implant in each half-arch or two implants in each half-arch;minimum bone height of 11 mm and minimum bone thickness of 5 mm in the posterior region of the bilateral mandible evaluated by means of cone beam computed tomography; sufficient prosthetic space for subsequent prosthetic rehabilitation	the need for some type of bone reconstruction or advanced surgery to allow the installation of the implant; patients who did not accept to be part of the study; patients with uncontrolled diabetes, considering glycated hemoglobin above 7.5%; smokers more than 10 cigarettes a day; use of oral or injectable bisphosphonates; immunodeficient patients; patients who underwent radiotherapy in the head and neck region for a period of less than five years before the beginning of the research; patients with another systemic condition that contraindicated performing oral surgery at the time or who had conditions that could interfere with the osseointegration process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-79ysyy6	Analysis of pain control in patients undergoing Pectoral Anesthetic Block (PEC) in Radical Mastectomies with Axillary approach in an Oncology Hospital in Maceió	Recruiting	Intervention	2021-08-19	<NULL>	<NULL>	4842	Analysis of pain control in patients undergoing Pectoral Anesthetic Block (PEC) in Radical Mastectomies with Axillary approach in an Oncology Hospital in Maceió	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Santa Casa de Misericórdia de Maceió	Santa Casa de Misericórdia de Maceió	https://ensaiosclinicos.gov.br/rg/RBR-79ysyy6	<NULL>	Women and men with breast cancer undergoing surgery for mastectomy and axillary dissection or sentinel lymph node research. Absence of use of routine analgesic medication	Women and men with breast cancer who will undergo conservative surgery. Drug users.Users of opioids or other routine painkillers.Chronic osteoarticular diseases, fibromyalgia, bone metastasis.Breast reconstruction using the latissimus dorsi or deep inferior flap.Chronic pain syndromes. Allergy to local anesthetics.Contraindication for simple painkillers. Local infection on the proposed block site. Coagulopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-7cbqt3	Analysis of particle diameter influence of a bone substitute of bovine origin, in the repair of bone surrounding the dental element, submitted to bone preservation technique after extraction. Randomized Clinical Trial.	Recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3278	Analysis of the influence of a xenogenic bone substitute particle&apos;s diameter on reparation of fresh dental alveoli, submitted to alveolar preservation. Randomized clinical study.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-7cbqt3	<NULL>	Thirty dental elements, incisors and maxillary premolars will be used, indicating extraction, and all adult participants of both genders	Active periodontal disease or previously affected teeth; current or previous smoker; head and neck radiotherapy; medical contraindication for dental surgery; diabetes; use of bisphosphonate and / or cyclosporine medicines; osteoporosis; osteopenia and periapical lesions on adjacent teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-9zftgs	Analysis of patient parameters related to oxygen therapy in patients undergoing anesthesia recovery	Data analysis completed	Intervention	2018-07-09	<NULL>	<NULL>	1979	Analysis of the Aldrete Kroulik scale related to oxygen therapy in patients undergoing anesthesia recovery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal de Minas Gerais - Escola de Enfermagem	Hospital das clínicas da UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9zftgs	<NULL>	Adult, age between 18 and 64 years; Classification of American Society of Anesthesiologists (ASA) 1 or 2; elective anesthetic-surgical procedure; general anesthesia; general conventional surgery; Peripheral oxygen saturation greater than or equal to 95% upon entering the Post Anesthesia Recovery Room.	Comorbidities of the respiratory system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-643zqt5	Analysis of physical activity and educational program on the burden and quality of life of caregivers of people with Amyotrophic Lateral Sclerosis.	Not yet recruiting	Intervention	2021-12-02	<NULL>	<NULL>	5067	Effects of a physical activity program through a teleservice with an educational program on overload, depression, stress and quality of life of caregivers of people with Amyotrophic Lateral Sclerosis: Randomized Controlled Clinical Trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal do Rio Grande do Norte	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-643zqt5	<NULL>	Be an informal caregiver of a person diagnosed with ALS, be over 18 years old. Not having cognitive impairment to understand the course and the term of clarification. Being a caregiver of people with ALS, without other neurological disorders, has to be literate, with complete elementary education.	If they present any pathology that prevents them from performing physical activity. Caregivers in the first trimester of pregnancy. Or, are taking psychiatric medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-5jzcc5q	Analysis of physiological markers, physical fitness, self-esteem and self-image in elderly people undergoing adapted Taekwondo	Recruiting	Intervention	2022-02-18	<NULL>	<NULL>	5228	Analysis of physiological markers of bone remodeling, muscle strength, functional autonomy, self-esteem and self-image in elderly undergoing adapted Taekwondo	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-06	Universidade Estácio de Sá	Universidade Estácio de Sá	https://ensaiosclinicos.gov.br/rg/RBR-5jzcc5q	<NULL>	Those who have not been exercising for at least 6 months will be included	Participants will be excluded if they present any contraindication for the regular practice of physical exercise, such as osteomyoarticular, metabolic or cardiovascular injuries, those who are undergoing hormone replacement or are at high risk in the pre-exercise screening proposed by PAR-Q.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-895c5hn	Analysis of quality of life before and after nasal surgery	Recruitment completed	Intervention	2021-06-11	<NULL>	<NULL>	4747	Analysis of quality of life before and after septoplasty and turbinectomy	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2019-06-13	Hospital Universitário da Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-895c5hn	<NULL>	Patients over the age of 18; both genders;  presenting nasal obstruction caused by septal deviation and/or inferior turbinate hypertrophy, that were refractory to drug treatment and needed surgical intervention; acceptance to participate in the study.	Presence of other causes of nasal congestion, such as chronic rhinosinusitis, nasosinusal polyposis and nasal tumors; presence of any lower respiratory tract abnormalities; refusal to enroll in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-9s776cs	Analysis of quality of life related to the condition of the gums and bone around the teeth and associated risk factors of pregnant women treated at basic health units	Recruiting	Observational	2024-11-19	<NULL>	<NULL>	8118	Analysis of quality of life related to periodontal condition and associated risk factors of pregnant women treated at basic health units	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-24	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9s776cs	<NULL>	Pregnant women in the 3rd trimester of pregnancy; between 18 and 40 years of age; regular follow-up with the obstetrician; diagnosis of Gestational Diabetes Mellitus, Arterial Hypertension/Pre-eclampsia, Obesity or association between such factors (for the high-risk pregnancy group) and without any systemic impairment (for the normal-risk pregnancy group); adequate cognitive and neuromotor behavior; adequate ability to perform regular oral hygiene	Need for complete rest for any medical reason; using, or having used at any time during pregnancy, antibiotics or any medication that may interfere with periodontal conditions; multiple tooth loss (more than two teeth per hemiarch); tooth loss prior to pregnancy due to periodontitis; undergoing orthodontic, periodontal or any dental treatment with another dentist; having previously undergone surgical periodontal treatment; pre-gestational depression; Diabetes Mellitus and High Blood Pressure prior to pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-7fhkrgz	Analysis of Root Apex Healing and Postoperative Pain in Root Canal Treatment of Posterior Teeth with Apical Preparation Performed Using Different Instrument Diameters	Recruitment completed	Intervention	2025-11-04	<NULL>	<NULL>	8500	Analysis of Periapical Healing and Postoperative Pain in Endodontic Treatment of Molar Teeth with Chronic Apical Periodontitis Using Different Apical Preparation Diameters: A Randomized Clinical Tria	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-02	Faculdade de odontologia da universidade federal do amazonas	<NULL>	<NULL>	<NULL>	Adult competent patients between 18 and 65 years old; diagnosed with chronic apical periodontitis in molar teeth; who have a telephone for contact; and who agree to the terms of the study.	Pregnant patients; patients diagnosed with type I or type II diabetes; patients with hypersensitivity to anti-inflammatory drugs or analgesics; patients without a telephone for contact; patients with root alterations or dental conditions that prevent endodontic treatment; patients who, for any reason, cannot undergo single-session treatment.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:19
RBR-5t258m	Analysis of Salivary Constituents of Elderly Patients with Gingivitis After Use of Dentifrice Incorporated with Brazilian Red Propolis	Not yet recruiting	Intervention	2020-07-09	<NULL>	<NULL>	3992	Analysis of Salivary Biomarkers in Elderly Patients with Gingivitis After Use of 1% Brazilian Red Propolis Based Dentifrice: A Randomized Clinical Trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5t258m	<NULL>	Healthy volunteers; both genders; presence of gingivitis; age over 65 years; presence of at least five dental elements.	Smoking volunteers; history of alcohol or drug abuse, presence of cognitive problems; dependency on caregiver for daily activities; professional application of fluoridated products in the last 3 months; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4mrftz	Analysis of small and conventional implants in the Maxilla.	Recruiting	Intervention	2018-04-18	<NULL>	<NULL>	1723	Analysis of extra-short and conventional implants in the posterior region of Maxilla.  splint-mounth randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4mrftz	<NULL>	Similar degree of atrophy in bilateral posterior maxilla region with a minimum subantral bone height of 4.0 mm and a width of 6.0 mm.	"General contraindications to surgeries with dental implants; Patient submitted to irradiation in head and neck region; Patients immunosuppressive and immunosuppression; Treated or being treated with anti-resorptive medicinal products or alter bone metabolism; Untreated periodontitis; Poor oral and low hygiene motivation; Pregnancy or Infant; Diabetes uncontrolled; Psychiatric problems or
unrealistic expectations regarding treatment; Substance abuse; Lack of dentition opposite the area intended to receive the implants; Extraction sites (Less than 3 months after extraction); Smoking."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-10ksfmxx	Analysis of strategies for Dental Sensitivity reduction: a medical study	Not yet recruiting	Intervention	2024-01-12	<NULL>	<NULL>	6722	Effects of Glutaraldehyde/HEMA-based products, S-PRG or 980nm Diode Laser on the Dentin Hypersensitivity treatment: a randomized controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10ksfmxx	<NULL>	Participants who have at least one tooth with dentin hypersensitivity, with a score equal to or greater than 4 on the Analogic Visual Scale (VAS). Participants must be aged between 18 and 65. Both genders. Having overall good health. Being available to attend the scheduled appointments and treatment sessions throughout the study period	Individuals with active caries lesions and/or defective restorations on the selected and/or adjacent teeth; structural dentin loss requiring restoration or periodontal treatment; prior use of professional desensitizing agents in the last 6 months; smokers; pregnant individuals; those using anti-inflammatory and/or analgesic medications during the study period - or up to 72 hours before the initial assessment; those who regularly use anticonvulsants, antihistamines, sedatives, and/or anxiolytics; have orthodontic appliances; have a history of or current presence of neoplasms in the head and neck region; or are allergic to any component of the products used in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-5gqtbv	Analysis of strength gain in the elderly after the application of resistance training protocols with the use of resistance with free weight and elastic resistance	Recruitment completed	Intervention	2020-07-28	<NULL>	<NULL>	4055	Analysis of strength gain in the elderly after the application of resistance training protocols with the use of different types of resistance: randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-02	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5gqtbv	<NULL>	Elderly men and women, aged between 60 and 75 years old, able to practice physical activities and proposed evaluations, availability to participate in activities, absence of medical contraindications to exercises, without any type of orthopedic lesion of the lower limbs, without previous experience in the resistance training or not having practiced it in the last 6 months.	The elderly will be excluded from the study if they have any physical problems and / or osteomioarticular impairments that can be aggravated by the knee extension and flexion movement or who are absent for 3 days consecutive to the training protocols.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-3bjjf4	Analysis of stress and sleep hormones in the nursing team that works the day after receiving massage to control symptoms and ways to cope with stress, pain and sleep: a randomized clinical trial	Recruitment completed	Intervention	2019-11-13	<NULL>	<NULL>	3185	Analysis of cortisol and melatonin in daytime nursing workers in the management of stress, pain, sleep and occupational coping strategies after the use of massage: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-05	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3bjjf4	<NULL>	Women aged 20 to 45 years; sleep period performed totally in the dark; belonging to the morning shift; score of 40 or more from the List of Stress Symptoms; working time in the hospital between one and three years; return of vacation or medical leave after 30 days.	"Smoking; hypertensive; use of beta-blockers, glucocorticoids, psychotropic and anxiolytics; pregnant women;
hysterectomized; professionals with holidays marked or on medical leave during the research period; early use of the previous drugs in the collection period; up to four sessions of other integrative practices two months ago; of integrative practices (during the period of data collection."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-6vbfszv	Analysis of Syringe Identification Pattern for Medication Administration during Anesthesia and its association with medication errors	Not yet recruiting	Observational	2022-06-01	<NULL>	<NULL>	5414	Analysis of Syringe Identification Pattern for Drug Administration during Anesthesia in Brazil and its association with medication errors in the perioperative period	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-12	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6vbfszv	<NULL>	Training anesthesiologists will be included; as well as those already trained; of public and private hospitals in different Brazilian regions	Anesthesiologists who refuse to sign the consent form or who show prior knowledge of the study to be carried out will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-3ccyk2	Analysis of the amount of fat, muscle and bone in older people without dementia and with Alzheimer&apos;s disease.	Recruiting	Observational	2020-04-06	<NULL>	<NULL>	3710	Analysis of body composition in older people preserved cognitively and with Alzheimer&apos;s disease.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3ccyk2	<NULL>	The eligibility criteria are older people aged 54 years old or over, not institutionalized and with the possibility of contacting them by phone or home address. Inclusion criteria are available to participate in the proposed evaluations; present diagnosis of Alzheimer&apos;s disease in the mild or moderate phases, according to the Diagnostic and Statistics Manual for Mental Disorders 4th edition (DSM-4) and the Dementia Assessment Score or be preserved cognitively.	The criteria for exclusion are sensorial or function commitments that affect the application of proposed tests and the presence of neurological diseases that interfere in cognition, such as Parkinson&apos;s disease, stroke, multiple sclerosis, Huntington&apos;s disease, epilepsy, and brain trauma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4nq8cbp	Analysis of the benefits of Electrical Stimulation on the memory of healthy elderly people	Not yet recruiting	Intervention	2021-12-02	<NULL>	<NULL>	5069	Transcranial Direct Current Stimulation on cognitive performance of healthy older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4nq8cbp	<NULL>	Sedentary elderly, of both sexes, aged between 60 and 90 years old, living in the municipality of Campo Grande / MS and who do not have neurological or psychiatric disorders	Elderly people with cognitive decline (associated or not with dementia), heart disease participants, subjects with difficulties in understanding the tests. Participants who have more than four consecutive absences in therapies and a recent crisis of labyrinthine dysfunction will also be excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-2mw2kwv	Analysis of the benefits of the vibrating platform on the balance of healthy older adults	Recruiting	Intervention	2022-07-15	<NULL>	<NULL>	5490	Investigation of the impact of the vibrating platform on the static balance of healthy older adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2mw2kwv	<NULL>	Elderly people with 60 years or more; without neurological and psychiatric disorders; living in the community.	Patients with cognitive decline; those with movement disorders; subjects with congenital or acquired amaurosis; those with severe cardiovascular and musculoskeletal comorbidities that preclude orthostatism and deambulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-5p8qtf	Analysis of the capacity of detection of carotid artery calcification through a new dental examination, comparing with the medical examination used	Recruitment completed	Intervention	2018-12-19	<NULL>	<NULL>	2400	Analysis of the Accuracy of Panoramic Radiography associated with the Anteroposterior Towne Technique of Modified Towne in the detection of Calcified Ateromas - comparison with Doppler Ultrasonography	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Pontifícia Universidade Católica de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5p8qtf	<NULL>	Patients with prior indication of Panoramic Radiography for dental treatment; with Doppler Ultrasonography of the bilateral carotid systems for cardiac monitoring purposes in less than 12 months; between 50 and 90 years.	Patients who presented difficulties in ambulation; Patients with disabling conditions that could hinder their participation; with cognitive deficit, who did not agree with the Terms of Free and Informed Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-3jdm6d	Analysis of the cardiac frequency and oxygenation during sleep in patients with the Obstructive Sleep Apnea Syndrome	recruiting	Observational	2012-04-24	<NULL>	<NULL>	141	Study of autonomic cardiac behavior and oxygen saturation during sleep in patients with the Obstructive Sleep Apnea Syndrome	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3jdm6d	<NULL>	"Individuals of both sexes;
Aged 18-80 years;
With suspicion diagnosis of obstructive sleep apnea;
Who underwent full polysomnography in sleep Institute of San Carlos;
Technical data could be analyzed;"	Patients who underwent polysomnography, but whose data are not technically acceptable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-7mwcqzm	Analysis of the correlation between lip thickness and Herpes Labialis lesions: a study in humans to evaluate the efficacy of an Ointment as a treatment	Recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8594	Analysis of the correlation between lip thickness and Herpes Simplex 1 lesions: in vivo, open-label, prospective, single-arm study on the efficacy of a Semi-Solid Formulation as a therapeutic intervention	<NULL>	2, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-16	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Participants aged 14 and older, provided they are accompanied and authorized by a legal guardian, or are over 18 years of age; male and female; individuals with any health condition, with no restrictions related to medical history (except allergies to components of the therapeutic intervention formula); p resenting prodromal signs and symptoms and contacting the researchers within the first 48 hours; availability and interest in adhering to the research protocol; previous clinical history of at least one episode of herpes lesion(s); absence of use of antivirals (systemic and topical) in the 15 days preceding the clinical phase of the study; absence of use of topical products (makeup, moisturizers, creams, and sunscreens) near and on the site of herpes lesions during the clinical phase; internet access (either via cell phone or computer) to complete the research questionnaires.	Participation in a different clinical study related to the treatment of cold sores and involving the use of antiviral and analgesic drugs (limited adherence to the study protocol); use of analgesics and anti-inflammatories in the prodromal phase; allergy to components of the therapeutic intervention formula and to local anesthetics (prilocaine and lidocaine); dry desquamation stage (hard crust); planned use of additional medications for cold sores during the study period; fever above 38°C during the clinical phase of the study; pregnant or lactating women; individuals who have undergone lip filler procedures (with any drug) in the last 12 months prior to the clinical phase of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-43vbh6b	Analysis of the effect of behavioral variables on the pattern of metabolic, cardiovascular and inflammation of physical growth among adolescents	Recruiting	Observational	2023-02-14	<NULL>	<NULL>	5907	Analysis of behaviors of children during growth	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade Estadual Paulista Julio de Mesquita Filho	Faculdade de Ciências e Tecnologia - UNESP / Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-43vbh6b	<NULL>	Healthy adolescents; both genders; aged between 11 and 20 years; signature of the free and informed consent form by the parents or legal guardian	Clinical or metabolic disorder that influences the practice of regular physical activity; regular use of medication that affects lipid parameters, blood pressure and bone metabolism; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-34v9px	Analysis of the effect of vibration in patients with stroke	recruitment completed	Intervention	2012-02-16	<NULL>	<NULL>	159	Analysis of the effects of low frequency vibration in patients affected by stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-03	Universidade do Vale do Sapucaí	Universidade do Vale do Sapucaí	https://ensaiosclinicos.gov.br/rg/RBR-34v9px	<NULL>	"Hemiparesis due to stroke with more than 3 months of injury; 
Age over 30 years; 
Both sexes; 
without distinction of race; color and socioeconomic; 
Level with mental competence assessed by the mini-mental examination and reduction of motor function assessed by rating scale Fugl-Meyer."	"Younger than 30 years; 
Acute cerebral vascular accident; 
low level of mental competence; 
Using pacemaker; 
Uncontrolled hypertension."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-5jszxw	Analysis of the effective dose for analgesia in knee surgery with saphenous nerve block by ultrasound	Recruiting	Intervention	2019-04-30	<NULL>	<NULL>	2641	Evaluation of the Minimum Effective Concentration (CEM) analgesic of ropivacaine in ultrasound guided safeno block for knee arthroscopy Randomized, double blind study	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5jszxw	<NULL>	Knee meniscopathy; meniscectomy surgery	Patient refusal; coagulopathy; pregnancy; local infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-2t9t7q	Analysis of the effectiveness of acupuncture as a therapeutic procedure in older people with tinnitus.	Recruitment completed	Intervention	2014-02-03	<NULL>	<NULL>	274	Analysis of the effectiveness of acupuncture as a therapeutic procedure in older people with tinnitus: randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-23	Universidade Norte do Paraná	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-2t9t7q	<NULL>	"Elderly individuals with complain of tinnitus of sensorineural origin;
Age of 60 years or more."	"Present active cardiovascular disease;
Possessing cardiac pacemaker;
Possessing metallic prostheses or implants;
Complain of tinnitus generated by the para-auditory system."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-2kkb6d	Analysis of the effectiveness of cinnamon in the reduction of sugar and fat levels of adults with type 2 Diabetes	Not yet recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3023	Analysis of the effectiveness of cinnamon (Cinnamomum verum) in the reduction of glycemic and lipidic levels of adults with type 2 Diabetes	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2kkb6d	<NULL>	Volunteers of both genders; aged between 18 and 80 years; diagnosis of type 2 diabetes confirmed for at least five years; taking oral antidiabetics; with HbA1c values between 6.5 and 8.0%; preserved cognitive functions.	Volunteers with cinnamon allergy; Patients who use another herbal medicine for diabetes treatment; Patients using cinnamon for diabetes treatment; Patients diagnosed with alcoholic liver disease, cirrhosis or abnormal basal liver function; Patients on insulin therapy; Women breastfeeding, pregnant or on contraceptives; Patients with heart, liver or respiratory failure; Patients with bleeding disorders and who are taking coumarin derivatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-72cyh7	Analysis of the effectiveness of different root canal treatments in the reduction of bacteria and their products	Data analysis completed	Intervention	2019-02-25	<NULL>	<NULL>	3508	Analysis of the effectiveness of endodontic procedures in the reduction of microorganisms and their by-products	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2016-10-15	Faculdade de Odontologia de Araçatuba - Unesp	Fundação de Amparo à Pesquisa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72cyh7	<NULL>	A total of 24 patients who presented with primary endodontic infection were included in this study. The teeth selected should have a primary endodontic infection, with absence of spontaneous painful symptomatology, absence of periodontal pocket with a depth greater than 4 mm, and that could be isolated with a rubber dam.	Those who received antibiotic, anti-inflammatory or analgesic treatment in the last three months or who had any uncontrolled generalized disease were excluded from work.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-6q2wx4t	Analysis of the effectiveness of exercises performed in water on the memory of healthy elderly	Not yet recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5048	Analysis of the effectiveness of aquatic physiotherapy on cognitive processes in healthy elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal Mato Grosso do Sul	Universidade Federal Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6q2wx4t	<NULL>	Sedentary elderly, of both sexes, aged between 60 and 90 years old, living in the municipality of Campo Grande / MS and who do not have neurological or psychiatric disorders	Elderly people with cognitive decline (associated or not with dementia), heart disease participants, subjects with fecal incontinence, unable to remain in orthostatism and people with difficulties in understanding the tests. Participants who have more than four consecutive absences in therapies, hydrophobia and a recent crisis of labyrinthine dysfunction will also be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-3n7pzqt	Analysis of the Effectiveness of the Anti-motion Sickness Glasses for Reading in Vehicles	Data analysis completed	Intervention	2023-08-17	<NULL>	<NULL>	6358	Validation of Antikinetosis Sickness Glasses for Reading in Vehicles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-03	APEC - Sociedade Potiguar de Educação e Cultura S.A	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3n7pzqt	<NULL>	Being a student at the Universidade Potiguar; having signs or symptoms of motion sickness while reading in vehicles; not being under the use of antikinetosis medication; be at least 18 years old.	The exclusion criterion is not meeting all the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-4fgh4z	Analysis of the effects of a program of physical exercise using the legs in the motor function of the arms in patients who have stroke	Not yet recruiting	Intervention	2018-10-10	<NULL>	<NULL>	2274	Analysis of the effects of an aerobic exercise program using lower member in the motor function of the upper limb in chronic patients after Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-30	faculdade de medicina de ribeirão preto	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fgh4z	<NULL>	Participants should have had an episode of ischemic stroke for at least 6 months, be between 18 and 80 years old, absence of joint blockages in the upper and lower limbs, ability to walk for 6 minutes independently and get on mini-examination of mental status score according to level of schooling.	Symptomatic cardiac arrhythmia (atrial fibrillation in anticoagulation), uncontrolled arterial hypertension (at the examiner&apos;s discretion), decompensated heart failure (functional class 2, 3 or 4), severe respiratory disorders (chronic obstructive pulmonary disease, pneumonia ), impossibility of attending the appointments and non-signing of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-7d4ff6q	Analysis of the effects of adding Pregabalin to the treatment of postoperative pain control in Hemorrhoid Surgery	Recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8672	Efficacy of Pregabalin as an adjuvant in multimodal pain control after Hemorrhoidectomy	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-08	Escola Paulista de Medicina da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	ASA 1 to 3 by the American Society of Anesthesiology; ages between 18 and 65 years; of both sexes; with grade III or IV hemorrhoidal disease indicated for Milligam-Morgan hemorrhoidectomy	Patients with cardiac arrhythmias; cardiomyopathy and/or cardiac conduction disorders; psychiatric, liver, respiratory, or oncological diseases; cognitive impairments that prevent proper completion of the forms; using analgesics in the week prior to surgery; associated surgeries; hypersensitivity to medications; active user of psychoactive drugs; consent forms signed incorrectly or without signature	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-3tnjtq	Analysis of the Effects of Caffeine on cognitive abilities and anxiety	Data analysis completed	Intervention	2018-02-01	<NULL>	<NULL>	1619	Analysis of the Effects of Caffeine on cognitive abilities and anxiety	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-08	Departamento de Biociências da Universidade Federal de São Paulo - Baixada Santista	Departamento de Biociências da Universidade Federal de São Paulo - Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-3tnjtq	<NULL>	healthy volunteers, both genders; age between 18 and 40 years; students of UNIFESP Baixada Santista;  minimum of 11 years of school education.	psychiatric diagnoses; obesity; dyslipidemia; cardiopathy; gestation; intellectual, visual and auditory deficiency; HIV on antiretroviral therapy; cirrhosis; renal failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-52pndym	Analysis of the effects of Physical Therapy and Low-Level Laser on the improvement of symptoms during drug treatment of Leprosy	Recruiting	Intervention	2022-09-22	<NULL>	<NULL>	5624	Application of Conventional Physiotherapy associated with Phototherapy for the treatment of Leprosy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Mato Grosso	Secretaria Municipal de Saude de Varzea Grande	https://ensaiosclinicos.gov.br/rg/RBR-52pndym	<NULL>	Patients diagnosed with leprosy; of both sexes; aged 18 years or older; using corticosteroids	Patients who do not use the medication as determined by the physician; individuals who do not attend the outpatient clinic for phototherapy and patients with Diabetes Mellitus and peripheral neuropathies resulting from other pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-747wrkx	Analysis of the Effects of Progressive Neuromuscular Training on Pain and Neuromuscular Performance in Elderly Women with Osteoarthritis of the Knee	Recruitment completed	Intervention	2021-10-20	<NULL>	<NULL>	4994	Analysis of the effects of progressive neuromuscular training on pain and neuromuscular performance in elderly women with knee osteoarthritis: clinical, randomized, controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-19	Faculdade de Enfermagem Nova Esperança-FACENE	Faculdade de Enfermagem Nova Esperança-FACENE	https://ensaiosclinicos.gov.br/rg/RBR-747wrkx	<NULL>	Elderly women, aged between 60 to 70 years; sedentary; with a clinical diagnosis of knee osteoarthritis according to the classification of Kellgreen and Lawrence Grade II or III (Hunter and Eckstein, 2009); who have not undergone any type of knee surgery; able to walk; who have limited their activities due to fear of falling; agree to participate in the study by signing the Informed Consent Form and who during the assessment do not present vestibular disorders.	Elderly women who present severe pain in the knees during the exercise protocol; as well as reduced mobility to the point of interfering with walking and with less than 25% compliance with the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-5t6j5p	Analysis of the effects of vocal training through breath exercises with sound in tube and straw in choir singers	Recruiting	Intervention	2016-05-27	<NULL>	<NULL>	863	Analysis of the effects of vocal conditioning through semi-occluded vocal tract exercises in choir singers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-21	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5t6j5p	<NULL>	Age between 18 and 60; score in Voice Sympton Scale (VoiSS) equal to or less than 16; signing of the Informed Consent (IC).	Voice disorders diagnosed by otolaryngologist physician; smokers; presence below 75% in the meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-37tjbg	Analysis of the electrical activity of muscles used in gait of paraplegic patients in two different gait training methods using a support of body weight	Data analysis completed	Observational	2017-01-11	<NULL>	<NULL>	1144	Electromyographic analysis of muscles used in gait of patients with spinal cord injury in two different training modalities with body weight suspension	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Fernanda Cechetti	https://ensaiosclinicos.gov.br/rg/RBR-37tjbg	<NULL>	Patients who agree to participate in the study and sign the Informed Consent Term (TCLE), with clinical diagnosis of spinal cord injury, ASIA C or D score, ie, incomplete injury with motor preservation below the neurological level, with Most of the key muscles below that level with less than or equal to three muscle strength, respectively, and are able to remain seated independently in a bed.	Patients who present with weight-bearing contraindications, such as a fracture of the hip or lower limb, or because they have bedsores. Also, patients who present with unstable angina or other decompensated heart disease, chronic obstructive pulmonary disease, neurological diseases such as Parkinson&apos;s or stroke or have a symptomatic drop in blood pressure when upright.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-2vj7sw	Analysis of the evolution of patients with Chronic Cervicalgia as a function of the Treatment of Choice.	Data analysis completed	Intervention	2019-01-02	<NULL>	<NULL>	3035	Analysis of the clinical evolution of the Patient with Non-specific Chronic Neck Pain as a Choice of Treatment Choice. A randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-2vj7sw	<NULL>	Current neck pain. Neck pain continued for at least the last twelve weeks.	Irradiated neck pain. Neck pain associated with dizziness. Osteoporosis. Psychological disorders. Vertebral fractures Tumors Metabolic diseases. Previous neck surgery Red Flags (Night pain, severe muscle spasm, loss of involuntary weight, symptom mismatch). Physiotherapeutic treatment continued in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-6cgy23	Analysis of the factors that may be related to the emergence of postural deviations in school.	Recruitment completed	Observational	2014-10-24	<NULL>	<NULL>	344	Analysis of risk factors related to postural changes in children from the city of Santa Cruz / RN	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-03-02	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6cgy23	<NULL>	The study included children and adolescents aged between 07 and 17 years enrolled in primary or secondary schools, municipal or urban schools, in the morning or evening, in the city of Santa Cruz / RN, whose parents or guardians signed the informed consent (IC) approved by the Ethics in Research Involving Human UFRN.	Presence of physical and / or mental efficiency, orthopedic injury, trauma and / or rheumatologic that prevented the maintenance of orthostatic position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-7wjrkp9	Analysis of the foot massage effect in patients with peripheral diabetic neuropathy	Terminated	Intervention	2022-10-13	<NULL>	<NULL>	5661	"Analysis of the concern of Foot Reflexology in patients with Diabetic Neuropathy
peripheral"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade do Vale do Sapucaí	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7wjrkp9	<NULL>	clinical diagnosis of type 2 diabetes; age between 55 and 75 years; 10 years or more onset of type 2 diabetes; Body Mass Index (BMI) of less than 29.9 kg / m2; neuropathic compromises and symptoms	superior motor neuron injury; constant use of muscle relaxant; use for gait aid and orthopedic; circulatory and / or dermatological problems of the lower extremities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-4w7zqjf	Analysis of the immediate effects of the application of acupuncture on physical and muscle performance parameters in young active practitioners	Recruitment completed	Intervention	2021-12-06	<NULL>	<NULL>	5080	Analysis of the Acute Effects of the Application of Systemic Acupuncture on Physical and Muscular Performance Parameters in active young practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-28	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4w7zqjf	<NULL>	Male athletes, professionals or amateurs will be included in the sample and are undergoing regular weekly training in their respective sports. The age range of these individuals must be between 16 and 40 years old.	The sample must be composed of healthy individuals on the day of the evaluations, so those who show signs such as more severe flu, respiratory tract infection, muscle and / or joint pain in general or any other type of pain in any part of the body will be excluded. body, have not suffered more serious muscle injuries or bone fractures in the last 06 months and have not been practicing any type of physical rehabilitation such as physiotherapy in the last days (due to some more recent physical impairment), have not been subjected to any process in the last 12 months surgical on any of the joints that can be used in the tests or any other surgery considered more delicate from a clinical point of view that requires greater care during and after rehabilitation for a longer time (such as cardiac or neural surgeries). Smokers with chronic diseases such as hypertension, diabetes, chronic kidney disease, coronary artery disease, autoimmune diseases, metabolic diseases under treatment such as cancer and AIDS and psychiatric diseases will also be excluded. The participation of female individuals will also be excluded due to changes in temperature due to hormonal variations, as well as during the menstrual cycle.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-9vsnz4	Analysis of the implantation of the home mechanical ventilation on the better at home program	Not yet recruiting	Observational	2019-12-02	<NULL>	<NULL>	3238	Analysis of the implantation of the home mechanical ventilation (VMD) in services of the better at home program	<NULL>	3, n/a, n/a	3	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital Alemão Oswaldo Cruz	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-9vsnz4	<NULL>	Home care services that possess the minimum conditions of admission of patients in invasive ventilation; Patients in invasive mechanical ventilation, regardless of age and cause that led to chronic ventilation, with conditions to receive care at home; services, patients and caregivers who agree to participate in the study.	Home care services that are not interested in participating in the study; home care services that do not have the minimum structure for the safe dehospitalization of patients in mechanical ventilation; refusal of the patient and/or family member to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-3fmc62z	Analysis of the incidence, severity and temporal evolution of motion sickness after using the Air Force Academy&apos;s T-2000, T-3000 and T-4000 flight simulators	Not yet recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7199	Analysis of the incidence, severity and temporal evolution of Simulator Sickness after exposure to the Air Force Academy T-2000, T-3000 and T-4000 flight trainers: An exploratory experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade da Força Aérea	Academia da Força Aérea	https://ensaiosclinicos.gov.br/rg/RBR-3fmc62z	<NULL>	Healthy volunteers; both genders; aviation cadets enrolled in the second or fourth year of the Air Force Academy&apos;s Aviation Officer Training Course. For the sample referring to second year cadets, it will be required to have successfully completed the Primary Flight Course on the Universal aircraft. For the sample referring to fourth year cadets, it will be required to have successfully completed the Basic Flight Course on the Tucano aircraft.	Be medically exempt from aerial activity or simulator training for any reason.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-2qcddnp	Analysis of the incidence, severity and temporal evolution of motion sickness after using the C-95M Flight Simulator	Not yet recruiting	Intervention	2025-08-22	<NULL>	<NULL>	8224	Analysis of the incidence, severity and temporal evolution of Simulator Sickness after exposure to the C-95M flight trainer: an exploratory experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-25	Comando da Aeronáutica	Base Aérea de Natal	https://ensaiosclinicos.gov.br/rg/RBR-2qcddnp	<NULL>	Healthy volunteers; both genders; trainee pilots of the transport aviation of the Natal Air Base	Be medically exempt from aerial activity or simulator training for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-9m7cqq	Analysis of the inflammatory response in patients with Chronic Obstructive Pulmonary Disease (COPD) after orange juice intake	Recruiting	Intervention	2017-09-20	<NULL>	<NULL>	1391	In vivo analysis of the inflammatory response in patients with Chronic Obstructive Pulmonary Disease (COPD) after orange juice intake	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Faculdade de Medicina de Botucatu Unesp	Faculdade de Ciências Farmacêuticas USP	https://ensaiosclinicos.gov.br/rg/RBR-9m7cqq	<NULL>	Age above 60 years old; clinical stability characterized by the absence of exacerbation in the last three months and regular use of medication including long-term home oxygen therapy.	Use of antioxidant supplements; use of systemic corticosteroids in the last three months; the presence of other respiratory diseases;  diagnose of other NCDs such as diabetes mellitus II, cancer, severe heart failure, kidney or liver; patients with more than 15% or 200 mL increase in FEV1 after bronchodilator administration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-108988gj	analysis of the inflammatory response of the dental pulp to direct pulp capping with polymeric nanoparticles of brasilian red propolis	Recruitment completed	Intervention	2021-10-01	<NULL>	<NULL>	4927	Pulp response to direct capping with polymeric nanoparticles loaded with red propolis from Alagoas	<NULL>	1-2, randomized-controlled, triple-blind	1-2	<NULL>	<NULL>	<NULL>	2018-03-10	Universidade Federal de Alagoas - UFAL	Universidade Federal de Alagoas - UFAL	https://ensaiosclinicos.gov.br/rg/RBR-108988gj	<NULL>	Individuals who signed the free and informed consent form; older than 18 years; under appropriate mental conditions to provide free and informed consent in writing; with extraction indicated for therapeutic reasons of healthy third molars; with good oral hygiene and without systemic impairment	"Patients with poor oral hygiene;
Bruxism;
Periodontal disease;
Caries;
Restorations on any surface;
pulp vitality;
Impossibility of absolute isolation;
systemic disease or health condition;
Inability to cooperate with the requirements of the research protocol and follow-up procedures;
Individuals who presented conditions associated with poor adherence to treatment, such as alcoholism, mental illness or drug dependence;
Women who were pregnant or recently given birth (last 6 months);
Team members (researchers and auxiliaries) directly linked to the study or their immediate relatives (spouse, parents, children, siblings);
Patients with a history of allergic reactions to bee stings and / or products derived from honey from bees, whether or not containing propolis"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-7856k3	Analysis of the Learning of Movement and Effect of the Intervention with use of Computer Task in Individuals after Stroke	Recruitment completed	Intervention	2019-01-17	<NULL>	<NULL>	4481	Analysis of Motor Learning and the Efect of Intervention with Virtual Reality use in Individuals after AVE	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7856k3	<NULL>	Clinical diagnosis of stroke sequelae with a minimum of 3 months; individuals who do not present a sequela of stroke for the control group; age group of 40 to 70 years; to perform physiotherapeutic treatment at the Clínica Escola de Fisioterapia de Presidente Prudente; sign the Term of Consent.	Visual deficit; auditory impairment or cognitive impairment; which impedes the understanding and execution of the proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-9tmm4d	Analysis of the mental and physical exhaustion and the relation with immune response of cancer patients submitted to exergames.	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1571	Analysis of mental and physical fatigue and its relatonship with cytokines in cancer patients submitted to exergames practice. Randomized, controlled, follow-up and cross-over study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-05	Universidade Federal de Alfenas	Fundação de apoio à pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9tmm4d	<NULL>	"Experimental group 1: individuals with cancer; of both genders; age between 18 and 80 years; in chemotherapy; in radiotherapy; classification of stage 0; I; II and III; surgical post with medical release for the practice of physical activities.

Experimental group 2: individuals with cancer; of both genders; age between 18 and 80 years; in chemotherapy; in radiotherapy; classification of stage 0; I; II and III; surgical post with medical release for the practice of physical activities."	Individuals without cancer diagnostic; cognitive disorders that hinder the explanation of the handling of virtual environments; serious infectious diseases; disabling diseases in upper and lower limbs; patients with myopathies; diseases with recognized change of collagen; with neurological diseases; for personal reasons do not wish to participate; previous contact with exergaming.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-3jx5n7	Analysis of the Mobility of patients hospitalized in the ICU submitted to Physiotherapy in relation to Perme Escore	Data analysis completed	Intervention	2018-06-18	<NULL>	<NULL>	3849	Analysis of the Mobility of critical patients submitted to Physiotherapeutic Intervention in relation to Perme Escore	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3jx5n7	<NULL>	Patients hospitalized in the adult ICU of the HC-UFU; older than 18 years; with MRC (muscle strength rating scale) between 36 and 48 points; hemodynamically stable.	Patients younger than 18 years; hemodynamically unstable; without muscular weakness acquired in the ICU; MRC greater than 48 points.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-89d82xv	Analysis of the morphology of the skull bones in patients treated with fixed appliances	Recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7327	Morphological and functional analysis of patients with mandibular lateral deviations treated orthodontically with the GEAW technique	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-05	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89d82xv	<NULL>	Need for orthodontic treatment; resence of mandibular lateral deviation; acceptance of treatment with fixed orthodontic appliances; aged between 18 and 30 years; both sexes	Missing teeth; unsatisfactory prosthetic rehabilitations; symptoms of moderate and severe temporomandibular disorder (TMD)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:59
RBR-6fzjjqx	Analysis of the occurrence of Urine Flow Obstruction in the recent postoperative period of patients undergoing different types of adjustments in the treatment of Urinary Incontinence. Clinical study with random choice of patients, with researchers and patients who do not know which treatment was applied	Recruiting	Intervention	2024-03-25	<NULL>	<NULL>	6894	Assessing incidence of Infravesical Obstruction in early post-operative of Autologous Fascial Sling between different tensioning technics: a randomized and double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-06	Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do Sul - HCPA	Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do Sul - HCPA	https://ensaiosclinicos.gov.br/rg/RBR-6fzjjqx	<NULL>	Patients from the Urology outpatient clinic of the Hospital de Clínicas de Porto Alegre; female; over 18 years of age; with failure of conservative treatment for stress urinary incontinence (behavioral therapy with or without a combination of physiotherapy or medication treatment) and agreeing to the informed consent form	Patients with neurogenic etiology of symptoms; previous bladder surgeries; patients with bladder lithiasis; underactive bladder; previous urinary retention and/or infravesical obstruction; interstitial cystitis; patients with urological cancers or grade &gt; 2 vaginal prolapse; patients with severe cardiopulmonary pathologies; acute symptoms of urinary tract infection or recurrent infections; diabetes mellitus decompensated; pregnant women; patients with postoperative follow-up time less than 12 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-9brv7dd	Analysis of the Oral Environment in patients treated with Laser Therapy for Oral Mucositis	Recruiting	Intervention	2025-06-28	<NULL>	<NULL>	8074	Analysis of the Oral Microbiome in patients treated with Photobiomodulation for Oral Mucositis	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2024-10-22	Hospital Erasto Gaertner	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9brv7dd	<NULL>	Patients with malignant neoplasms in the head and neck region; undergoing radiotherapy treatment; both genders; no minimum or maximum age limit	Patients undergoing chemotherapy; uncontrolled or severe periodontal disease; application of oral topical medication; use of systemic corticosteroids; anti-inflammatory therapy; patients with salivary gland tumors; surgical removal of major salivary glands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-4d4q42	Analysis of the order of a Concurrent Exercise Session of the Blood Pressure of controlled Hypertense Elderly	Data analysis completed	Intervention	2020-01-28	<NULL>	<NULL>	3413	Analysis of the order of a Concurrent Exercise Session of the Blood Pressure of controlled Hypertense Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Programa de Pós-graduação em Ciências da Saúde	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4d4q42	<NULL>	To participate in the study, the elderly should meet the following inclusion criteria: male between 60 and 80 years old; do not exercise regularly and systematically for at least three months; do not present with musculoskeletal problems or cardiovascular complications that prevent physical exercises; present a medical certificate proving that you are fit for physical exercise; do not have a history of stroke or acute myocardial infarction; do not make use of smoking; not diagnosed with diabetes mellitus; do not exercise during the evaluation period; no pacemaker.	To exclude the study participant, he / she should: have some cardiovascular complication during the collections; not attending all evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-8d2s62	Analysis of the results obtained in the post-operative surgery where an implant replaces the knee joint	Recruiting	Intervention	2015-09-02	<NULL>	<NULL>	1113	Clinical analysis of new knee prothesis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-12	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Ortopedia e Traumatologia	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Ortopedia e Traumatologia	https://ensaiosclinicos.gov.br/rg/RBR-8d2s62	<NULL>	Healthy participants; both sexes;  60 to 70 aged years; with a diagnosis of osteoarthritis of grade IV and V according to Ahlback classification modified by Keyes; not have performed arthroplasty knee surgery earlier; failure of nonsurgical treatment (medication or physical therapy); not psychiatric disorders; not have diseases that have bone loss; not have chronic diseases including rheumatic diseases; not an alcoholic.	Participants with serious injuries in the operated knee; have deep infection; deep vein thrombosis without control with medical treatment; leaving treatment or follow-up; participant who no longer wish to perform the stipulated protocol; participant&apos;s death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-467cv6	Analysis of the results of an intensive therapy for the legs in the gait and in the balance of patients who suffered stroke.	Recruiting	Intervention	2019-08-20	<NULL>	<NULL>	3352	Effects of Lower Extremities - Constraint Induced Therapy on gait and balance function in chronic hemipretic post-stroke patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-30	Associação de Assistência a Criança com Deficiência	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-467cv6	<NULL>	Medical diagnoses of stroke, ischemic or hemorrhagic; stroke at least 6 months before study participation; clinically stable; hemiparesis caused by stroke; gait deficit caused by stroke; being able to begin hip and knee flexion on the affected side; moving from sitting to standing independently even with aid or support of upper limbs; being able of transferring while sitting independently; being able to sustain the body weight on the affected side even with support of another person and/or aid; being able of walking at least 10 meters with or without aid, with or without support of another person, barefoot; having only one or two main caregivers or relatives who live with the patient or spend substantial parts of the day with him; being available to go to the rehabilitation center for 17 consecutive days and staying there for 3 hours per day, 15 days of treatment and the first day for initial tests and the last day for the final tests; has not been subjected to orthopedic surgery for at least 6 months at the beginning of the protocol; has not been subjected to chemical block for at least 3 months at the beginning of the protocol; do not present an independent community gait.	Not accepting the protocol for which they were randomly allocated; having speech deficits that incapacitates the participant to understand and/or answer properly to evaluation scales and exercises selected for the protocol and having suffered any clinical event between the screening and the beginning of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-3wvq7b	Analysis of the short-term effects of the Schultz relaxation technique on the response of the Autonomic Nervous System induced by anxiety medications	Recruiting	Intervention	2020-04-13	<NULL>	<NULL>	3743	Analysis of the acute effects of the Schultz technique on the response of the Nervous System Autonomic induced by anxiolytics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Escola Paulista de Medicina- UNIFESP	UNESP - Faculdade de Filosofia e Ciências - Câmpus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-3wvq7b	<NULL>	Volunteers with anxiety disorder; taking anxiety medication; nonsmokers; age between 18 and 30.	Volunteers with reported cardiorespiratory and / or endocrine disorders; individuals using drugs that alter cardiac autonomic regulation; smokers; women between 11th to 15th or 21st to 25th day after the first day of the last menstrual cycle; those who drank alcohol or caffeine 24 hours before collection and those with a BMI above 25.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7w4szm	Analysis of the situation of Diabetes in the state of Espírito Santo and the actions developed by health professionals	Recruiting	Observational	2018-09-05	<NULL>	<NULL>	2174	Spatial analysis of Diabetes and evaluation of health practices developed: a contribution to health planning and decision making in the state of Espírito Santo, Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, EMESCAM	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7w4szm	<NULL>	Professionals working in the units for at least six months; users attended by professionals selected for at least six months; users with complications resulting from diabetes	Recent users in the unit; unregistered users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-6d3xcxs	Analysis of the stability of different types of dental implants	Recruiting	Intervention	2021-03-31	<NULL>	<NULL>	4592	Analysis of the primary stability of hybrid implants with different thread configurations. a split mouth randomized clinical controlled trial.	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2021-01-02	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-6d3xcxs	<NULL>	Age between 18 and 60 years; Necessity for bilateral unit rehabilitation with osseointegrated implants; Sufficient bone availability to install conventional sized implant; Good systemic health.	Smokers and ex-smokers; Diabetics; Patients who are chronic users of medications (eg. Bisphosphonates, immunosuppressants, anti-inflammatories) or pathologies that alter bone metabolism (eg. Osteoporosis; diabetes); Patients who chronically use anti-inflammatories and antibiotics; Patients with bruxism; Alcoholics ; Chemical dependents; Pregnant or women wishing to become pregnant in the next year; History of radiotherapy treatment in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-78dvhgs	Analysis of the stability of Implants with different macrogeometries	Not yet recruiting	Intervention	2025-10-03	<NULL>	<NULL>	8353	Comparative analysis of the initial stability of Dental Implants with different macrogeometries: in vivo study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Márcio de Carvalho Formiga	Universidade do Vale do Itajaí	https://ensaiosclinicos.gov.br/rg/RBR-78dvhgs	<NULL>	18 years old or more; systemic healthy; no contraindications for implant surgeries; no need for bone grafts; with at least one site in the need for implant supported rehabilitation; good oral health conditions;	smokers; diabetes; patients with history of use of bisphosphonates oral or endovenous; patients with the need for bone grafts; any type of systemic condition that would contraindicate oral surgeries;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-796fgc	Analysis of the trunk muscles in people with low back pain after treatment through Pilates	Recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1586	Electromyographic analysis of the trunk muscles in subjects with non-specific low back pain submitted to a Pilates protocol	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-11	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-796fgc	<NULL>	"Low back pain group: both sexes, nonspecific low back pain, age between 18 and 40 years;
Control group: both sexes, aged between 18 and 40 years, clinically healthy;"	Specific low back pain; congenital malformation; sensory or motor changes, illnesses that impede the performance of the exercises, Pilates exercises for less than 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9b4gwz	Analysis of the type of patient submitted to heart surgery and the period during and after surgery at Hospital and Maternity Marieta Konder Bornhausen	Data analysis completed	Intervention	2018-08-06	<NULL>	<NULL>	2097	Analysis of the surgical profile and the immediate postoperative and postoperative period of patients submitted to cardiac surgery at the Hospital and Maternity Hospital Marieta Konder Bornhausen	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade do Vale do Itajaí	Universidade do Vale do Itajaí	https://ensaiosclinicos.gov.br/rg/RBR-9b4gwz	<NULL>	Patients (or caregivers) who signed the ICF, who were hospitalized in an intensive care setting after cardiac surgery.	Patients who underwent mechanical ventilation for more than 24 hours; patients who did not tolerate the use of the NIV mask; protocol follow-up error	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-6hxyft	Analysis of the whitening effect and sensitivity during dental whitening using the Violet Light: Clinical study	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2156	Analysis of bleaching and neurosensory efficacy of dental sensitivity during dental bleaching using Violet Light: A double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6hxyft	<NULL>	Vital and healthy upper teeth. Absence of dental caries. No visible defects of the enamel. Absence of orthodontic appliance. Good systemic conditions. Healthy oral soft tissues. Non smokers. Patients who have never performed bleaching treatment.	Conoid teeth. Direct and indirect restorations in the upper anterior region. Adverse reactions to peroxide. Use of opiates or drugs that influence the neurosensory response. Use of pacemaker. Presence of dental pigmentation (tetracycline, trauma, fluorosis and unknown etiology). Neurological diseases. Chronic or acute diseases. Dentinal exposure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-4h6h9fd	Analysis of Tooth Extraction Area Filled for Particulate Dentin or Blood Clot: A Randomized Split-Mouth Clinical Trial	Recruiting	Intervention	2024-07-24	<NULL>	<NULL>	7149	Analysis of Post-Extration Dental Alveoli Filled by Particulate Dentin or Blood Clots: A Ranzomized Split-Mouth Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4h6h9fd	<NULL>	Healthy patients; both genders; from 18 to 65 years old; indication of bilateral extraction of lower third molars; in accordance with the signing of the Free and Informed Consent Form; attended at the clinics of the Dentistry Course at the University of Passo Fundo and/or at the Centro de Estudos Odontológico Meridional	"Patients with serious comorbidities; users of alcohol, tobacco and/or illicit drugs; diseases or medications that affect bone metabolism; serial unilateral extractions; teeth with endodontic lesions,
deep caries, periodontitis or recurrent pericoronitis"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-43c2vv	Analysis of Two Physical Exercise Trainings in Elderly Over 80 Years	Recruitment completed	Intervention	2013-05-09	<NULL>	<NULL>	194	Analysis and Comparison of Two Physical Exercise Trainings and Their Detraining in Oldest Old	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-43c2vv	<NULL>	Inclusion criteria are age between 80 and 95 years old, live in community, sedentary lifestyle and ability to walk without help from another person with/without aid walking at least 500 meters.	Exclusion criteria are any cardiovascular or infectious comorbity described in the absolut contraindications list of Physical Activity Readiness Medical Examination (2002) (acute infectious disease, dissecting aneurism of aorta, severe aortic stenosis, congestive heart failure, unstable angina, acute myocardical infarction, acute myocarditis, pulmonary or acute systemic embolism, thrombophlebitis, ventricular tachycardia and other dangerous arrhythmias). Relative contraindications of cognitive, neurological and/or musculoskeletal comorbidities which make participation in protocols impossible. Score in mini-state examination mental below the cutoff score designated by education level.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-7699xz	Analysis of walking training with partial weight support for post stroke patients.	Data analysis completed	Intervention	2016-05-04	<NULL>	<NULL>	828	Multidisciplinary analysis of a motor rehabilitation protocol with partial weight support for post stroke patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Pontifícia Universidade Católica do Paraná	Centro Hospitalar de Reabilitação Ana Carolina Moura Xavier	https://ensaiosclinicos.gov.br/rg/RBR-7699xz	<NULL>	"The intended sample of 50 volunteers must satisy the following criteria:
Confirmed stroke; lower limb residual hemiparesis; score 1 to 5 at Functional Ambulation Cathegory; age above 18 years old."	Present sequelae in both sides of the body or bilateral stroke; Diagnosed cardiac condition instable; present another neurological conditions (i.e. Alzheimer, Parkison, dementia, cerebelar disease, severe cerebelar disorders, etc); severe muscoloskeletal lower limb disorders not related to stroke and might interefere in gait; trunk circumference shorter than 36 cm or larger than 142 cm, body mass larger than 138 kg, height larger than 210 cm, due to the limitations of tue body weight support equipment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-759bvb	Analysis on the maintenance of the bone around the implants with threads in their neck. Study in humans.	Not yet recruiting	Intervention	2018-05-28	<NULL>	<NULL>	1854	Evaluation of the remodeling of bone crest and marginal bone around implants with cervical microthreads. Clinical study in humans.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Centro Universitário de Araraquara	Centro Universitário de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-759bvb	<NULL>	To be included in the study, the patient should present at least two edentulous areas with a minimum healing period of 3 months post-extraction and without the need for reconstructive therapies. These patients should have good periodontal condition and good general health status.	The exclusion criteria will be: need for prior tissue reconstruction, smokers, alcohol users, drug users, uncontrolled diabetics, oral or intravenous bisphosphonate therapy, bruxism or parafunction patients, or patients with systemic diseases that are known to interfere osseointegration of the implants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-7bwvpj	Analyze the behavior of blood pressure in the elderly, After A Execício Session Held in Physical Academy of the Third Age in Rio de Janeiro City	Recruitment completed	Intervention	2016-11-07	<NULL>	<NULL>	1066	Effect of Exercise Held in the Third Age Academies of Rio de Janeiro City (ATI-RJ) About Behavior Blood Pressure in Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-10	Universidade Salgado de Oliveria	Universidade Salgado de Oliveria	https://ensaiosclinicos.gov.br/rg/RBR-7bwvpj	<NULL>	Elderly aged between 60 and 90 years of age, both genders; released by their doctors for physical activity.	No regular physical activity for 2 or more days week within the last two months; smoking habit; cardiac disease well as infarction, coronary arterial disease or stroke within the previous year; chronic kidney disease; bone, muscle or joint limitations precluding exercise performance; use of drugs influencing the autonomic nervous system, particularly beta-blockers; uncontrolled hypertension defined as systolic blood pressure  160 mmHg and or diastolic blood pressure equal to or greater than 105 mmHg at rest.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-5mnf4zp	Analyzing a desensitizing protocol for visible tooth whitening: a clinical, blind, randomized study	Recruitment completed	Intervention	2021-11-23	<NULL>	<NULL>	5056	Analysis of a desensitizing protocol for external tooth whitening: a randomized, blinded clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5mnf4zp	<NULL>	Good general and oral health; 18 to 50 years old; have at least six upper anterior teeth free of caries, restorations or endodontic treatment; canines shade A2 or darker as assessed by the VITA shade scale (VITA Classical Shade, VITA Zahnfabrik, Bad Säckingen, Germany).	Orthodontic appliances; dental prosthetics; severe internal tooth discoloration; pulped teeth; pregnant and nursing women; patients with bruxism or any pathology that may cause sensitivity; recession; dentin exposure; visible cracks; patients who use anti-inflammatory drugs or analgesics; patients who underwent tooth whitening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-72mfkv8	Analyzing the relationship between total sleep time in patients undergoing Orthopedic Rehabilitation	Recruiting	Observational	2023-11-04	<NULL>	<NULL>	6563	Relationship of total sleep time in the Rehabilitation of orthopedic patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-21	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-72mfkv8	<NULL>	Patients of both genders. Adults aged 30 to 59 years. With musculoskeletal injuries (hip and knee). With a Body Mass Index of normal (18.5-24.9 kg/m 2 ) to overweight (24.9- 30kg/m2). Patients who had sleep disorders and/or insomnia. Patients who voluntarily agree to participate in the study and sign an informed consent form. Patients who are able to fulfill study requirements, such as keeping a sleep diary and regularly participating in rehabilitation sessions	Patients with a history of serious psychiatric disorders such as schizophrenia or bipolar disorder. Patients with severe neurological disorders such as Cerebrovascular Accident (CVA) or spinal cord injury. Patients with serious chronic illnesses such as Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF). Patients who are using medications that affect sleep, such as benzodiazepines or antipsychotics. Patients who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-4xtw6z	Anesthesia of the  quadratus lumborum muscle guided by ultrasound as exclusive method of anesthesia in the correction of the Inguinal Hernia by videolaparoscopy	Recruitment completed	Intervention	2019-05-07	<NULL>	<NULL>	2664	Ultrasound guided quadratus lumborum block as an exclusive method of anesthesia on Extraperitoneal Laparoscopic correction of Inguinal Hernia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Santo Amaro	Instituto de responsabilidade social sirio libanes - hospital geral do grajau	https://ensaiosclinicos.gov.br/rg/RBR-4xtw6z	<NULL>	Patients with unilateral inguinal hernia, without severity criteria, ASA (American Society of Anesthesiologists) 1-2, aged between 18 and 80 years. During outpatient care, a quality of life questionnaire was applied prior to surgery, evidencing pain patterns and restrictions on preoperative activities.	Surgery time over 120 minutes, surgical complications such as bleeding, infection or conversion to open surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-43rj8f2	Anesthesia training	Not yet recruiting	Intervention	2021-10-14	<NULL>	<NULL>	4986	Simulation in anesthesiology	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-43rj8f2	<NULL>	Volunteer medical students or medical residents or professors of anesthesiology; both sexes.	Volunteers under 18 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-4m5pdbf	Anesthesia without Narcotic Analgesic for Obesity Surgery: is there a benefit?	Data analysis completed	Intervention	2022-03-25	<NULL>	<NULL>	5300	Opioid-free Anesthesia for Laparoscopic Gastroplasty: is there a benefit?	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-01-13	Universidade Federal do Paraná	Hospital Nossa Senhora das Graças	https://ensaiosclinicos.gov.br/rg/RBR-4m5pdbf	<NULL>	Body mass index major or equal to 35; indication for gastroplasty surgery; age over 18 yers old	Refusal to participate in the study; chronic pain or chronic use of analgesics; any condition or pathology that could change the perception of pain; heart blockages or major arrhythmias; patients anesthetized differently from the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-8yyzzz	Anesthetic Effect of Articaine 2% with Epinephrine 1: 200,000 with Sodium Bicarbonate in Maxilla Infiltration	Recruiting	Intervention	2020-05-18	<NULL>	<NULL>	3842	"Effect of Alkalinization of the 2% Articaine Hydrochloride Solution with Epinephrine 1: 200.000 on anesthetic efficiency in infiltration in the maxilla
Crossover randomized clinical trial"	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2019-02-14	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8yyzzz	<NULL>	Healthy individuals; age between 18 and 45 years; similar level of education, from incomplete third grade; previous experience of local anesthesia; absence of history of complications resulting from local anesthesia; presence of healthy maxillary incisors, canines and premolars	Pregnant women; infants; volunteers with systemic impairment that contraindicate anesthesia; volunteers who present a history of allergic reaction to any component of the anesthetic solutions used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-4vvkhz	Anesthetic occupational exposure during medical residency - impact on oxidative stress and toxicogenomic, biochemical and neuroendocrine assessments: longitudinal study	Recruitment completed	Observational	2017-12-01	<NULL>	<NULL>	4462	Anesthetic occupational exposure during medical residency - impact on oxidative stress and toxicogenomic, biochemical and neuroendocrine assessments: longitudinal study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-25	Departamento de Anestesiologia	Faculade de Medina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-4vvkhz	<NULL>	Start of medical residency in 2015 in anesthesiology areas; general surgery; orthopedics; neurosurgery; healthy volunteers; both genders; age between 18 and 35 years	Have done medical residence in the areas of interest of the study; Carrier malignancy; be more than 35 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-59g3wf	Anesthetic properties of two solutions used in the injection technique with less dense bone and greater penetration with the use of electronic injector	Not yet recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2131	Anesthetic properties of two solutions in the Alveolar Crest Technique Spongeous Bone Zone using injector	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-59g3wf	<NULL>	Be between 18 and 35 years of age; Patients of both sexes; Patients who were not submitted to blockade anesthesia in the region in the two weeks prior to the study; Do not use any medication of action of the central nervous system; ASA I and II patients with no history of hypersensitivity to the drugs under study; Present units 36 and 46 in need of restorative treatment;	Pregnant women; History of psychiatric illness that may compromise the ability to provide informed consent; History of drug dependence or abusive alcohol consumption; Odontophobic; Patient ASA III and IV	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-2nbmpbc	Angiotensin- (1-7) supplementation in physical exercise practitioners	Recruitment completed	Intervention	2023-01-06	<NULL>	<NULL>	5804	Angiotensin- (1-7) as a new ergogenic supplement for exercise practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-20	Laboratório de Fisiologia do Exercício	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-2nbmpbc	<NULL>	Athletes and practitioners of physical exercise; older than 18 years; involved in their training programs for at least one year; have participated in competition in the last six months at the regional level	Present some type of illness that compromises data collection; individuals with any type of pathology; smokers; make use of medications such as anti-inflammatories and antibiotics and / or others that may compromise research data; as well as supplements that interfere with cardiovascular parameters such as caffeine and guarana	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-2x56pw8	Angiotensin-(1-7) oral formulation improves physical performance in mountain bike athletes	Data analysis completed	Intervention	2021-01-11	<NULL>	<NULL>	4474	Effect of the oral formulation Hpbcd / Angiotensin- (1-7) in the treatment of muscle microlesion induced by sports practice	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-03	Grupo de pesquisa em Mecanofisiologia	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-2x56pw8	<NULL>	healthy volunteers; of both genders; older than 18 years; impeded in their cycling training programs for at least 12 months; conduct at least four MTB training schools per week.	make use of supplements with a potential stimulating effect on the cardiovascular system (such as caffeine and guarana powder); history of current injuries or in the last six months; not willing to abstain from intense exercise 24 hours before the test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-39v9n67	Animal-Assisted Therapy in pediatric dentistry: an intervention study with dogs	Recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7858	Animal-Assisted Therapy in pediatric dentistry: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-13	Faculdade Meridional - IMED	Faculdade Meridional - IMED	https://ensaiosclinicos.gov.br/rg/RBR-39v9n67	<NULL>	Patients aged between 5 and 12 years; of both sexes; who require at least 2 restorative procedures and/or extractions under local anesthesia; who are in good general health; without significant medical conditions that would interfere with participation in the study, preventing the child from understanding and interacting with the animals	Patients with serious medical conditions; known phobia/aversion and allergies to dogs; and children with cognitive disabilities that may affect communication and understanding of instructions necessary to perform the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-2vbfbh9	Animated infographic to guide hospital discharge of elderly patients with urinary catheters: a quasi-experimental study	Data analysis completed	Intervention	2025-10-06	<NULL>	<NULL>	8362	Animated infographic for hospital discharge of elderly people with indwelling urinary catheter: a quasi-experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-13	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2vbfbh9	<NULL>	Be 60 years of age or older, undergo urological surgery and keep the urinary catheter after hospital discharge	Elderly individuals who have used a urinary catheter at some point, as it is assumed they already know how to take care of themselves. Also, elderly individuals who are not cognitively capable of answering the questions in the data collection instrument	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-7n2w7zt	Ankle exercises on muscle responses in athletes and active adults	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7929	Effect of short-foot on musculoskeletal responses in athletes and recreationally active adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-7n2w7zt	<NULL>	Adult volunteers of both sexes; must not engage in any physical activity other than that proposed in the experiment; must be free from functional limitations that would prevent them from performing the tests and/or the proposed protocol; and must engage in less than 300 minutes of physical activity per week	Must not be consuming caffeine-based or stimulant ergogenic aids; must not report any acute dizziness; must not present abnormal fluid accumulation (edema), particularly in the lower limbs; must not have been diagnosed with conditions affecting postural control, such as vestibular dysfunction, Alzheimer’s disease, Parkinson’s disease, or motor neuron disorders; must not have a history of lower limb trauma in the past year; and must not be currently engaged in a structured exercise program focused on postural control	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-3bt9sb	Ankle range of motion assessment in professional soccer players	Data analysis completed	Observational	2020-07-03	<NULL>	<NULL>	3974	Ankle Test application in the assessment of ankle range of motion in professional soccer players	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	universidade federal de sergipe	universidade federal de sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3bt9sb	<NULL>	SUB-19 football players who are enrolled in the 2019 Sergipe championship	Not being entered in the competition or having an injury on the day of the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4g8m6y7	Anti-Aging Treatment with PDRN and Growth Factors: Evaluation of Results and Safety	Recruiting	Intervention	2025-01-29	<NULL>	<NULL>	7694	Evaluation of the Efficacy and Safety of Anti-Aging Treatment with PDRN and Growth Factors	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2024-09-18	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-4g8m6y7	<NULL>	Patients of both sexes; diagnosed with facial sagging will be included in the study; aged between 20 and 80 years; and who have no contraindications for facial volumization procedures	Patients with a history of photosensitivity; keloids; hypertrophic scars; and post-inflammatory hyperpigmentation; as well as those who are pregnant or lactating; will be excluded from the study; Individuals with local inflammatory skin disorders or active herpes infection at the procedure site will also be excluded; as well as individuals with a history of medical conditions that contraindicate the procedures; such as intolerance to the components; urticaria; Raynaud&apos;s disease; or a history of allergic reactions to the components; Finally; patients who do not agree to participate in the study will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-27sdv5	Anti-human globulin Rh D drug from effectiveness from review after vaccination in women with postpartum negative factor blood and with complications risk in newborns	Recruiting	Intervention	2016-03-02	<NULL>	<NULL>	735	Evaluation of clinical efficacy of Kamrho-D® drug (anti-human globulin Rh D - Panamerican) in postpartum women Rh negative immunization, coombs indirect negative and sensitization risk	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2013-02-01	Hospital São Lucas da PUC/RS (Centro Coordenador)	LAL Clinica Pesquisa e Desenvolvimento Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-27sdv5	<NULL>	"Postpartum women who agreed to participate and sign and date back to the Informed Consent (IC);
Postpartum women over the age of 18;
negative Rh postpartum women, Coombs negative indirect analyzed by gel agglutination method, whose newborn is Rh +."	"Simultaneously be participating or have participated in another clinical study within the last 12 months;
postpartum women allergy sufferers to any of the components of the formula;
postpartum women with IgA deficiency history or story to IgA antibody;
postpartum women with a history of autoimmune hemolytic anemia with pre-existing risk with hemolysis or hemolysis;
postpartum women who have positive Indirect Coombs test at the beginning of treatment;
postpartum women who have given birth to negative Rh fetuses;
postpartum women with abnormalities of the coagulation system;
Patients who used elaborate vaccines with live pathogens in the last 03 months or will do during the study;
Patients with pre-natal clinical diagnosis of liver disease and / or severe nephropathy.
At the discretion of the Principal Investigator of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-49q54wg	Anti-inflammatory activity of Physalis-based cream after laser application in the treatment of spots on the hands	Data analysis completed	Intervention	2021-02-12	<NULL>	<NULL>	4550	Anti-inflammatory activity of the cream based on Physalis angulata L. extract after application of intense pulsed light in the treatment of solar melanosis of the hands	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Paranaense	Universidade Paranaense	https://ensaiosclinicos.gov.br/rg/RBR-49q54wg	<NULL>	Healthy volunteers; both genders; ages between 26 and 76 years; non smokers; weight within the range of 15% of the weight considered normal for men and women taking into account height and physical structure; similar involvement by melanosis in both hands; negative dermoscopy for premalignant lesions; phototype between I to IV.	Volunteers with autoimmune diseases; hives; photosensitivity; previous history of skin cancer; pre-malignant lesions on the skin; signs of loss of skin barrier in the treated region; smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-3wvbvx7	Anti-plaque effectiveness from Oil Pulling	Recruitment completed	Intervention	2022-02-18	<NULL>	<NULL>	5226	Antiplaque Efficacy Evaluation from Oil Pulling: Double-Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Jéssica Gomes Alcoforado de Melo	Jéssica Gomes Alcoforado de Melo	https://ensaiosclinicos.gov.br/rg/RBR-3wvbvx7	<NULL>	"- No signs of gingival inflammation: bleeding on probing in 10% or more of the sites and probing depth ≤ 3 mm;
- Biofilm accumulation with score ≥ 1;
- Do not use orthodontic appliance or removable prosthesis;
-Have ≥ 22 teeth present in the mouth;
-Be healthy systemically.
-No allergy to coconut oil, sesame oil and chlorhexidine.
-Agree to participate in the research by signing the Informed Consent Form and having received, verbally and in writing by the researchers, all information and clarifications."	"- Had been treated with antibiotics and anti-inflammatory drugs in the last six months;
- Smokers, pregnant and lactating women;
- History of use of antimicrobial mouthwashes, gels or chewing gums in the last three months;
- History in the last few months of any dental condition that needed immediate attention (abscess, pericoronitis, edema, periodontal disease)
- Teeth with probing depth ≥ 4 mm with signs of gingival inflammation;
- Teeth with gingival retraction ≥ 2 mm."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-7qzb27m	Antibacterial activity of a Simvastatin emulsion in patients with Atopic Dermatitis	Recruiting	Intervention	2024-10-29	<NULL>	<NULL>	7461	Antimicrobial Activity of a Topical Simvastatin Emulsion in patients with Atopic Dermatitis: double-blind randomized, placebo controlled, crossover clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2022-07-15	Faculdade de Ciências Farmacêuticas da Universidade Estadual de Campinas	Faculdade de Ciências Farmacêuticas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7qzb27m	<NULL>	Age between 2 and 60 years; Atopic Dermatitis  diagnosis according to the Hanifin and Rajka criteria, confirmed by reviewing the medical record; patients under follow-up at the dermatology outpatient of the referred hospital for at least 6 months; presence of active lesions in the upper limbs; not using topical corticosteroids of any potency at the product application site 30 days before the start of the study; atopic dermatitis severity assessed by a physician through the measurement of the Eczema Activity Severity Index (EASI) greater than 7; atopic dermatitis severity assessed by a physician using the Atopic Dermatitis Antecubital Severity score (ADAS); both genders	Presence of any other dermatosis in the product application area; history of hypersensitivity to simvastatin oral administration or any other statin; unstable skin condition defined by at least one of the following criteria in the last 3 months: change of systemic medication, antibiotics uses, hospitalization due to atopic dermatitis; oral antihistamines will be allowed as long as they are maintained at the dose prior to the start of the study; change in topical treatment in the month prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-9z76pk4	Antibiotic prevention with Levofloxacin in children with Acute Lymphoblastic Leukemia	Recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5725	Antibiotic prophylaxis with Levofloxacin in chemotherapy induction in children with Acute Lymphoblastic Leukemia - a randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-07-07	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9z76pk4	<NULL>	Patients with an initial diagnosis of Acute Lymphoblastic Leukemia; age from 1 year to 18 years.	Children with clinically or microbiologically documented infection before initiation of induction or with fever before induction therapy that required prolonged antibiotic therapy (more than 5 days); history of allergy to the use of quinolones; history of chronic arthritis being treated; patients who developed febrile neutropenia within the first 7 days of induction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-4b5kzhd	Antibody persistence at 6 months or more in individuals primed with 2 doses of an inactivated vaccine who received a heterologous or homologous third dose – extension of study RHH_001 and safety and immunogenicity of a 4th dose with recombinant covid-19 vaccine (AstraZeneca/Fiocruz) or mRNA covid-19 vaccine (Comirnaty, Pfizer/ Wyeth)	Not yet recruiting	Intervention	2022-08-17	<NULL>	<NULL>	5557	Persistence of binding and neutralizing antibodies against SARS-CoV2 strains at 6 months or more after a third dose with recombinant covid-19 vaccine (AstraZeneca/Fiocruz), mRNA covid-19 vaccine (Comirnaty, Pfizer/ Wyeth), recombinant covid-19 vaccine (Janssen) or adsorbed inactivated Covid-19 vaccine Coronavac (Sinovac/ Butantan) in subjects primed with two Sinovac/Butantan doses – extension of study RHH_001 and assessment of safety and immunogenicity of 4th dose with recombinant covid-19 vaccine (AstraZen	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-10-15	Instituto D&apos;Or de Pesquisa e Ensino	Universidade de Oxford	https://ensaiosclinicos.gov.br/rg/RBR-4b5kzhd	<NULL>	Participants in study RHH 001 per protocol population who were fully evaluable. Those participants included in previous neutralization assay subsets will be targeted for enrolment first if operationally feasible; Subjects willing and able to provide informed consent prior to any study procedure; Participants willing and able to comply with the study procedure; Subjects who had received heterologous or homologous third vaccine dose 6 months or more prior to this study. For part 2 in addition: nformed consent to receive 4 th vaccine dose, AstraZeneca/Fiocruz or Pfizer/Wyeth; No contraindication against AstraZeneca/ Fiocruz or Pfizer/ Wyeth SARSC0V2 vaccine; For females of childbearing potential: willingness to practice continuous effective contraception during the study and a negative pregnancy test on the days on day of vaccination.	Any additional SARSCoV2 vaccine after the 3rd dose in study RHH 001. For part 2 in addition: Participants with a history of serious vaccine-related adverse reaction or serious allergic reaction (e.g., anaphylaxis) to any study vaccine component, as described in the last summary of product characteristics for AstraZeneca/Fiocruz or Pfizer/Wyeth; Participants with a known bleeding disorder that, in the investigator’s opinion, would contraindicate intramuscular injection; Participants with any progressive or serious neurological disorder, seizure disorder or history of Guillian-Barré syndrome; Participants given treatment with immunosuppressant therapy within the last 90 days, including cytotoxic agents or systemic corticosteroids or planned receipt during the study period. If a short-term cycle of immunosuppressant systemic corticosteroid dose has been used to treat acute disease, the participant should not be enrolled in the study until corticosteroid therapy has been discontinued for at least 15 days prior to the first study vaccination. In case the participant has been on an immunosuppressant dose of a depot, intramuscular or intra-articular corticosteroid, 60 days should be waited for their enrolment in the study. Inhaled/nebulized, intra-articular, intrabursal or topical (skin or eyes) corticosteroids are allowed; Participants with autoimmune diseases, other than: Hashimoto thyroiditis, vitiligo, psoriasis, discoid lupus and the like; HIV positive participants and/or in treatment for HIV; Participants given any other investigational product within the 30 days prior to administration of 4th dose or who intend to take part in another clinical trial at any time during this study conduction; Participants given any other licensed vaccine within 14 days prior to enrolment in this study or who plan to receive any vaccine up to 28 days after vaccination; Participants given treatment with Rituximab or any other anti CD20 monoclonal antibody within 9 months prior to administration of 4 th dose or planned during the study period; Administration of intravenous immunoglobulins and/or any blood products within 3 months prior to enrolment or planned dosing during the study period; Participants with any condition that, in the investigator’s opinion, could interfere with the status primary objectives or represent an additional risk for the participant. Temporary exclusion criteria for both Part 1 and Part 2: Participants with a recent history of COVID19 (minor 4 weeks prior to visit 1) will be delayed until 4 weeks after diagnosis; Participants with fever major 37.5 °C (axillary) or any acute disease at baseline (Day 1) or within the 3 days prior to randomization. Febrile participants with mild diseases may be enrolled at the investigator’s discretion once fever has resolved.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-7gstxs6	Antimicrobial action of cleaning methods for dentures of hospitalized patients	Terminated	Intervention	2022-03-25	<NULL>	<NULL>	5302	Antimicrobial effectiveness of denture cleaning protocols for hospitalized patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Karin Hermana Neppelenbroek	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7gstxs6	<NULL>	Patients in hospital ward; both sexes; over 18 years old; users of conventional removable upper complete; any condition of the mandibular arch; any level of consciousness; any reason for hospitalization.	Patients with fractured and/or relined upper complete dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-3kjjc4	Antimicrobial effects of Silver Diamine Fluoride compared to Chlorhexidine	Recruitment completed	Intervention	2018-10-16	<NULL>	<NULL>	3920	Antimicrobial effects of treatment with  Silver Diamine Fluoride compared to Chlorhexidine	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-21	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-3kjjc4	<NULL>	"Patients who present at least one active carious lesion in deciduous molar located in the external half of the dentin, without pulpal or periodontal disease;
Both sexes;
Age range: 7 to 10 years."	"Children whose parents did not sign the Informed Consent Form;
Children who did not assent to participate in the study;
Children who had some type of systemic impairment and/or special needs throughout treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-10b6dcpr	Antimicrobial photodynamic therapy and photobiomodulation in alveolar socket healing of diabetic Patients	Terminated	Intervention	2025-04-27	<NULL>	<NULL>	7958	Antimicrobial photodynamic and photobiomodulation therapies on alveolar dental socket repair in diabetic patients: a double-blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10b6dcpr	<NULL>	Type 2 diabetic patients of both genders; age between 35 and 60 years; requiring extraction of erupted permanent teeth, either by simple alveolar techniques or complex open flap extractions; clinical and laboratory examinations performed to standardize the sample; fasting blood glucose levels between 110 and 250 mg/dl; glycated hemoglobin (HbA1c) values up to 7.5%; controlled hypertension with an average blood pressure up to 150/100 mmHg	"We did not include individuals who had used analgesic or anti-inflammatory drugs in the last 15 day Smokers
Patients in use of antiresorptive drugs ز  patients with renal insufficiency; a history of hypothyroidism or hyperthyroidism. chronic pain. neurological or psychiatric disorders; pericoronitis; or any other condition indicative of acute local infection or bisphosphonates at any time; were excluded; Smokers, pregnant women, individuals with a family history of photosensitivity; and those allergic to postoperative pain medications or anti-inflammatory drugs were also not included"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-9shcypr	Antimicrobian photdynamic therapy applied in necrosis of the jaw bones	Recruitment completed	Intervention	2026-03-09	<NULL>	<NULL>	8956	aPDT applied in osteonecrosis of the jaws	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-15	Fundação Antônio Prudente	<NULL>	<NULL>	<NULL>	any age; male or female; osteoradionecrosis; medication-related osteonecrosis of the jaws; who signed the Informed Consent Form.	patients who did not have the clinical conditions to undergo antimicrobian photodynamic therapy (aPDT); who did not agree with this therapeutic modality; stage 0	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-3h2xcn	Antioxidant effect of carqueja infusion in climacteric women	Recruitment completed	Intervention	2018-07-10	<NULL>	<NULL>	1986	Evaluation of the antioxidant activity of Baccharis trimera infusion (Less.) Dc. in climacteric women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3h2xcn	<NULL>	Women will be included who accept to participate in the research through the signing of the Free and Informed Consent Form, TCLE. Adhere for three months to treatment with Baccharis trimera infusion. Perform all stages of research protocol evaluations.	Women will be excluded the following drug classes are in continuous use: Hormone Replacement Therapy, HRT or who have previously had this treatment; vitamin supplement, medications for HAS, DM. Women who use medicinal plants on an ongoing basis;Women with low acceptability of Baccharis trimera infusion; Women who participated in the last 6 months of research with herbs, herbal medicines and functional foods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-2crspbc	Antispastic effect of Transcranial Magnetic Stimulation in Multiple Sclerosis	Recruitment completed	Intervention	2023-07-11	<NULL>	<NULL>	6223	Effects of Transcranial Magnetic Stimulation on spasticity in Multiple Sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-05	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2crspbc	<NULL>	over 18 years old; left lateral hemispheric dominance; confirmed diagnosis of multiple sclerosis; who present grade 3 spasticity according to the ashworth scale; the subtypes (remitting relapsing, primary progressive and secondary progressive); who have motor evoked potential for quadriceps	Application of phenol; botox or other procedures that interfere with quadriceps muscle tone within a period equal to or less than 6 months; Fracture or recent surgeries in lower limbs; Contracture or ankle deformity; History of seizures or refractory epilepsy; brain metallic implants; brain tumors or skin lesion at the application site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-42sg8j2	Anxiety and Depression Diagnosis and Treatment	Data analysis completed	Intervention	2021-01-26	<NULL>	<NULL>	4489	Depression and Anxiety Ambulatory: Study about Clinical Profile, diagnosis and mental health therapy short-course.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal do Pará	Hospital Universitário Bettina Ferro de Souza	https://ensaiosclinicos.gov.br/rg/RBR-42sg8j2	<NULL>	Volunteer patients,aged between 18 and 30 years old, of both sexes, who reported having depressive symptoms, but were not undergoing psychotherapeutic or psychopharmacological treatment; who were interested in knowing, studying and practicing the art of clowning; that they did not have physical limitations that would prevent them from practicing the exercises proposed during the workshop; and who agreed to participate in the study by signing the Informed Consent Form (ICF).	Patients under 18 years old or over 75 years old, who had physical dissipation that prevented them from practicing the exercises proposed during the workshop	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-678f5pf	Anxiety and depression in patients with frozen shoulder. Worst functional results obtained in cases of more severe anxiety and depression?	Recruiting	Observational	2022-03-14	<NULL>	<NULL>	5277	Anxiety and depression in patients with frozen shoulder. A cross-sectional analysis associated with functional correlation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-19	Hospital Ortopédico de Belo Horizonte	Hospital Ortopédico de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-678f5pf	<NULL>	Those male and female patients; age between 18 and 75 years; those diagnosed with primary frozen shoulder of idiopathic etiology; those who have x-ray and magnetic resonance exams for differential diagnosis of their injuries	Those with secondary frozen shoulder, that is, those with a report of local trauma; history of previous surgeries; chondral injury in the glenohumeral joint; lip lesions; synovitis; intra-articular free bodies; history of prolonged shoulder immobilization; presence of heterotopic ossification; calcific tendonitis; rotator cuff injury; glenohumeral arthrosis; inveterate dislocation of the shoulder; skin burn scars at the site; history of neurological damage to the central or peripheral nervous system; those who do not register their consent by signing the free and informed consent form; those who present incomplete data in the protocol of this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-9j7rs22	Anxiety and satisfaction of surgical patients	Not yet recruiting	Intervention	2023-04-18	<NULL>	<NULL>	6018	Anxiety and satisfaction of surgical patients undergoing educational intervention: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Departamento de Enfermagem da Faculdade de Medicina de Botucatu	Hospital das Clinicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-9j7rs22	<NULL>	Adult patients undergoing elective colorectal surgeries in any segment; age equal to or greater than 18 years; both gender	Patients with any kind of difficulty in verbal and written communication or comprehension; patients submitted to surgical reoperation due to complications arising from a previous surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-5r5sc5	Anxiety and singing: influence of administration of a single dose of Oxytocin in men	Recruiting	Intervention	2017-03-08	<NULL>	<NULL>	1181	Anxiety and singing voice: clinical parameters and effects of acute administration of Oxytocin in men	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-10-20	Faculdade de Medicina de Riberão Preto - Universidade de São Paulo	Faculdade de Medicina de Riberão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5r5sc5	<NULL>	Male singers; Aged between 18 and 35 years; With training or experience in singing voice of at least three years; Perform at least one musical presentation in public.	Use of the following medications; Antihistamine, antidepressants, antihypertensive, hypoglycemic and anti-inflammatory; Complaint of auditory acuity; History of neurological disease, psychiatric disorders, renal, pulmonary, hepatic and / or cardiovascular problems; Abuse of alcohol, tobacco and users of illicit substances; Moderate to severe dysphonia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-39gws45	Anxiety control in dental surgery	Recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7240	The efficacy of Alprazolam for Anxiety control in third molar extractions	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-39gws45	<NULL>	Healthy volunteers; both genders; aged between 18 and 40 years; requiring extraction of retained third molars in similar positions regarding the type of impaction	Patients under 18 years old or over 40 years old; patients with body weight below 50kg or above 90kg; patients who have used anti-inflammatory or analgesic drugs up to 1 week before the first dental intervention; patients with a history of contraindication to the use of benzodiazepines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-2t5j87	Anxiety in children undergoing dental treatment: a comparative study	Recruiting	Intervention	2019-08-27	<NULL>	<NULL>	2900	Anxiety in children undergoing dental treatment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2t5j87	<NULL>	"Children attended at the pediatric outpatient clinic of the State University of Western Paraná.
Age between 8 and 9 years.
Children of both genders."	Children with physical disability and / or mental impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-9cph2q	Anxiety in musicians and recognition of the face&apos;s emotions: study about the possible effects of oxytocin.	Not yet recruiting	Intervention	2016-06-29	<NULL>	<NULL>	902	Musical performance anxiety and recognition of facial expressions: clinical randomized study involving the general population and acute effects of oxytocin	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Faculdade de Medicina de Ribeirão Preto - USP	Flávia de Lima Osório	https://ensaiosclinicos.gov.br/rg/RBR-9cph2q	<NULL>	Age above 18 years; Male sex; Professional activities or amadora as a musician, with frequent public presentations at significant audiences.	Neurological and / or psychiatric disorders, excluding anxiety disorders; Renal, pulmonary, hepatic and / or cardiovascular diseases; Current use of tobacco, psychoactive substances and any kind of medication; Harmful alcohol use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-7h6f6p	Anxiolytic effect of NSR meditation on emotions of university students	Recruiting	Intervention	2017-01-19	<NULL>	<NULL>	1163	Effect of NSR meditation on the anxiety levels of university students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7h6f6p	<NULL>	University students of both sexes, aged between 18 and 30 years who do not present pathological conditions that could interfere with the results, such as neurological, metabolic and psychiatric disorders; who did not use chronic medication; who did not present pre-menstrual complaints; and who had no previous experience with meditation or relaxation techniques.	Waiving by the volunteer; who present pathological conditions that could interfere with the results, such as neurological, metabolic and psychiatric disorders; who use chronic medication; who present pre-menstrual complaints; and who had previous experience with meditation or relaxation techniques.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-6pvzyt	Aplicattion of Hipromelosis (Ophthalmic Gel) in Lacrimal Punctum Closure in Dry Eye Patients	Data analysis completed	Intervention	2013-07-31	<NULL>	<NULL>	218	Occlusion of Inferior Lacrimal Punctun with Hypromelosis in Dry Eye Patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-09-01	Hospital Universitário de Brasília - Universidade de Brasília	Hospital Universitário de Brasília - Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6pvzyt	<NULL>	"Age over 18 years; Age under 70 years;
Ambulatorial patients of HUB-Hospital Universitário de Brasília ; Dry eye patients; Patients complaining about current treatment; no other ocular diseases previously or during the study."	Develop systemic or ocular disease during the study; Initiate use of new systemic or ophthalmologic medications in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-7hr7ws	Appearance of mouth sores as a side effect of Docetaxel treatment in patients who had cryotherapy	Recruiting	Intervention	2020-04-06	<NULL>	<NULL>	3707	Oral mucositis in Docetaxel-treated patients who had cryotherapy	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital das Clinicas de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7hr7ws	<NULL>	Patients older than 18 years in the first cycle of chemotherapy with docetaxel.	It will be excluded from the study patients with indication or history of radiotherapy treatment; other chemotherapy regimens; active smokers in the last 90 days; patients with cancer lesions affecting the head and neck region; patients with clinically identified oral lesions or infections; patient with active periodontal disease in the immediate pre-Qt; patients who do not complete pre-QT dental preparation; carriers of autoimmune diseases; patients with infectious complications from any site; neurological or psychomotor alterations that hinder self-care, cryotherapy and / or response to questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-2vcncpm	Applicability of a sedation adjustment scale as well as orotracheal tube removal in pediatric patients: a randomized clinical trial	Recruiting	Intervention	2022-04-14	<NULL>	<NULL>	5346	Applicability of the comfort-behavior scale as predictor of weaning in pediatric patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal de Alfenas - UNIFAL MG	Hospital Universitário Alzira Velano	https://ensaiosclinicos.gov.br/rg/RBR-2vcncpm	<NULL>	Admitted to the pediatric intensive care uni; use of invasive mechanical ventilation; both genders; sedation use continues until extubation	Use of neuromuscular blockers; tracheostomy; service transfer; death; parents do not accept the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-98h5zxw	Application dose of photoestimulation on neuromuscular, functional variables and post-exercise recovery: randomized clinical trial	Recruitment completed	Intervention	2022-03-31	<NULL>	<NULL>	5320	Dose-response of clustered photobiomodulation on neuromuscular, functional variables and post-exercise recovery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-10	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-98h5zxw	<NULL>	Young people who do not practice systematic physical activities, aged between 18 and 35 years old, of both sexes. Those who did not have neurological and cognitive impairments, cardiorespiratory diseases and a history of joint or muscle damage in the last six months, as well as chronic injuries.	Present any type of muscle and / or joint injury during the collection period or have sought consent to participate in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-5vcmzfs	Application for the detection of the risk of increased blood pressure at the beginning of pregnancy	Not yet recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7249	Assistance Application for Prediction of Preeclampsia in the First Trimester Gestational Quarter: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5vcmzfs	<NULL>	Pregnant women over 18 or under 18 who are accompanied by a legal guardian; Unique pregnancy; Pregnancy between 11+0 and 13+6 weeks of evolution	prior kidney disease; Committed physical or mental health that makes interaction with researchers unfeasible at any time of study data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7dg79b	Application of a Physiotherapy treatment for undiagnosed Headache associated with muscle pain in students of a public university	Recruitment completed	Intervention	2019-09-24	<NULL>	<NULL>	2992	Application of a Physiotherapeutic Protocol for nonspecific muscle tension-associated Headache in students of a public university	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-05	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7dg79b	<NULL>	Individuals regularly enrolled in the UEPA Physiotherapy course of both sexes who present a non-specific headache at least once a week, associated with muscular tension in the neck, shoulders or back of the body.	Individuals with a specific diagnosis of specific headache; headache frequency less than once a week; individuals with headache not associated with muscle strain on the neck, shoulders or back of the body; individuals who are not available twice a week for the application of the physiotherapeutic protocol and who present a contraindication to the use of infrared.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-3pmvvnx	Application of an application connected to a game with stimulation of mastication and swallowing muscle activity in elderly people with Parkinson&apos;s disease	Recruitment completed	Intervention	2023-04-04	<NULL>	<NULL>	5983	Efficacy of a gamified android mobile device with Electromyographic Biofeedback for mastication and swallowing function in elderly people with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-14	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3pmvvnx	<NULL>	People with Parkinson&apos;s disease: both sexes; aged over sixty years; who have diagnoses of idiopathic PD according to Ordinance No. 228/2010 of the Brazilian Ministry of Health; are between stages 1 to 3 of the disease; people with teeth or using dental prostheses, guided and cared for by family members. Healthy elderly: individuals of both sexes will be included; age over 60 years; with teeth or using dental prostheses and that they are guided.	People with Parkinson&apos;s disease: diagnosed with other neurological diseases associated with PD; cognitive impairment; edentulous in both dental arches, or in the region of posterior teeth with missing teeth without antagonist and with severe dysphagia. Healthy elderly: those with cognitive impairment and who are edentulous in both dental arches.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-858zn7	Application of an educational action in pregnant adolescents on humanized delivery	Not yet recruiting	Intervention	2020-09-14	<NULL>	<NULL>	4245	Effects of an educational intervention for pregnant adolescents in the preparation for normal and humanized delivery	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-10-13	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-858zn7	<NULL>	"Age between 14 and 19 years
Gestational age from 16 weeks;
Attend prenatal care regularly;
Have a smartphone for intervention with a mobile app"	"hearing and visual impairment;
Do not attend prenatal consultations on the scheduled days;
Gestational age above 28 weeks;
Pregnant women with indication for cesarean section known since prenatal care;
Premature birth"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-9rf33n	Application of an Electrical Therapy Technique on different body parts for Treatment of Urinary Urgency.	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	2492	Comparison of the effects of Transcutaneous Electrostimulation of the Tibial Nerve with Parassacral in women with Urinary Urgency: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9rf33n	<NULL>	Women over the age of 18; with urinary urgency, self-reported and confirmed by a score greater than or equal to 8 in the Overactive Bladder - Validated 8 - Question Awareness Tool (OAB-V8)	To present stress urinary incontinence without symptom of urgency; being with urinary tract infection during the collection period; presenting habits of alcoholism, smoking or drug addiction; lesions and altered cutaneous sensitivity in the place where the procedure will be applied; cognitive deficit; treating (medication or physical therapy) for urinary incontinence or overactive bladder; to have any neurological disease; being in the gestational or puerperium period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-4q5whj	Application of an unsupervised fitness program in cancer patients	Recruitment completed	Intervention	2020-04-07	<NULL>	<NULL>	3715	Application of a Home Based Unsupervised Fitness Program in Cancer Patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-05	Centro Universitário Sudoeste Paulista - Itapetininga	associação de portadores de câncer de Itapetininga – SP APCDI	https://ensaiosclinicos.gov.br/rg/RBR-4q5whj	<NULL>	"Individuals aged 18 to 70 years; of both genders; have a diagnosis of cancer without specifying the type of affected person;
these individuals must be or have already completed treatment whether it be chemotherapy or radiation therapy"	Cardiovascular problems, metastasis, acute respiratory problems, cognitive dysfunction and immune deficiency, Explanations about the protocols, objectives, risks of participation and the right to withdraw from the project will be given during the first visit to the patient	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-68bwkc	Application of antimicrobial gel aiming to treat periodontal disease (gingival disease)	Data analysis completed	Intervention	2018-09-14	<NULL>	<NULL>	2510	Clinical evaluation of metronidazole semi-solid and film-forming formulations for the treatment of periodontal disease	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2015-05-05	Faculdade De Odontologia de Ribeirão Preto	Faculdade De Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-68bwkc	<NULL>	Chronic periodontitis with a clinical insertion level equal to or greater than 5 mm in two or more teeth and depth of probing equal to or greater than 5 mm in one or more periodontal sites (MACHTEI et al., 1992); age range from 35 to 70 years; not have used antibiotics for at least 3 months; absence of history of allergy to the components present in the formulations tested.	"Volunteers with severe cardiovascular disease;
volunteers with problems related to pharmacokinetics, such as nephropathies, liver diseases, etc."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5wfcmwv	Application of artificial intelligence in the design of single crowns on implants in the anterior region	Recruiting	Observational	2025-03-17	<NULL>	<NULL>	7838	Design of single crowns on implant in anterior region by artificial intelligence	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-16	departamento de odontologia	Departamento de Engenharia de Computação e Automação	https://ensaiosclinicos.gov.br/rg/RBR-5wfcmwv	<NULL>	Individuals over 18 years of age; of both sexes; with stable occlusion; with all upper and lower anterior teeth aligned and healthy or with single-sided restorations that do not alter their morphology. For the second stage of training, models with a trunnion-type abutment in the anterior region of the maxilla and their respective antagonist models will be selected from the Laboratory database in dental prosthetics	Individuals with missing anterior teeth; undergoing orthodontic treatment or with pathological tooth migration resulting from periodontal disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-9gxbg6	Application of Different Medications to prevent the Sensitivity of Tooth Whitening	Recruitment completed	Intervention	2017-12-14	<NULL>	<NULL>	1525	The Effect of Different Medications in preventing the Sensitivity caused by Tooth whitening	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2016-01-15	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9gxbg6	<NULL>	Patients with good general health will be included in this study; Age between 18-50 years of age; Good oral hygiene; Absence of caries in the anterior and inferior teeth; Absence of palatal and vestibular restorations; Upper central incisors with A2 or darker shading, which will be evaluated with Vita Classical scale (VITA Classical Shade, Vita Zahnfabrik, Bad Säckingen, Germany).	Patients who have undergone previous bleaching procedures will be excluded; That have restorations on the anterior superior teeth; Who have canal treatment in the anterior teeth; Pregnant and / or breastfeeding; With severe internal discoloration (tetracycline, spots, fluorosis, non-vital teeth); Parafunctional habits such as bruxism; Or any other pathology that may cause sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-829dqnf	Application of Elastic Bandage after Breast Equality Surgery: Randomized Clinical Trial - Breastaping II	Recruiting	Intervention	2024-04-12	<NULL>	<NULL>	6932	Application of Taping in the Intraoperative period of Symmetrization Surgery after treatment for Breast Cancer: Randomized Clinical Trial – Breastaping II	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-11	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-829dqnf	<NULL>	be female; individuals aged 18 ato 70; having been diagnosed with breast cancer; have an indication for surgical treatment to symmetrize the breasts; understand the objectives and instruments used in the research	have an allergy to the taping tape; have neurological diseases (e.g. Parkinson&apos;s Disease, Multiple Sclerosis, etc.); present psychological disorders that impede understanding of the research and assessment instruments; being undergoing surgical treatment for recurrence of breast cancer; Participants who develop infections, hemorrhages, hematomas or other complications (except scar dehiscence) in the P.O. period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-4s4fnqc	Application of Elastic Bandage after fat aspiration surgery from the abdominal region and flanks in women: randomized clinical trial	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7274	Application of Taping in the Immediate Post-Operative after plastic surgery in women undergoing Liposuction in the abdominal and flank region: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-11	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4s4fnqc	<NULL>	Be female; individuals aged 20 and 70; have an indication for surgical treatment of liposuction of the abdominal region and flanks for breast fat grafting; understand the objectives and instruments used in the research	Have an allergy to the taping tape; have uncontrolled diabetes; have neurological diseases (e.g. Parkinson&apos;s Disease, Multiple Sclerosis, etc.); present chronic use of anti-inflammatory and diuretic medications in the last 3 months; present psychological disorders that impede understanding of the research and assessment instruments; Participants who develop infections, hemorrhages, bruises or other complications in the postoperative period will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:58
RBR-29495g	Application of exercises after cardiovascular surgery	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3532	Application of a mobilization protocol, based on the functional level, after cardiovascular surgery: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-27	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-29495g	<NULL>	Adults patients admitted to the ICU after cardiac surgery (myocardial revascularization, valve replacement / repair, correction of thoracic aortic diseases and combined procedures) or vascular surgery (revascularization of upper / lower limbs and correction of abdominal aortic diseases), from January 2020 to June 2021, with modified Barthel index for walking ? 4 will be included	"Cardiorespiratory arrest
 Brain injury, with motor response &lt;5 (Glasgow coma scale)
 Recent acute myocardial infarction
 Unstable fractures
 Pregnancy
 Medical guidelines for maintaining absolute rest due to patient severity
 Unable to understand verbal commands
 Mechanical ventilation time for more than 24 hours
 Enrollment in another clinical study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-6p32m3	Application of high frequency and microcurrent in the healing process of skin wounds	Data analysis completed	Intervention	2020-01-29	<NULL>	<NULL>	4647	High frequency and microcurrent efficacy in ulcer healing process: an experimental clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-10	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-6p32m3	<NULL>	carriers of ulcers; of both sexes; age between 18 and 90 years; residents in the municipality of Patos de Minas-MG; available for application of the procedures at the Physiotherapy Clinic of the University Center of Patos de Minas	pacemaker carriers, uncontrolled hypertension, osteomyelitis; pregnant women; individuals with necrosis or infected ulcers, using oral and topical healing drugs, mentally disabled; patients with a history of cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-4k7zh3	Application of ice in the oral cavity of people using chemotherapy for cancers with 5-fluorouracil: a randomized clinical trial	Recruiting	Intervention	2017-09-29	<NULL>	<NULL>	1409	Cryotherapy applied to people using antineoplastic chemotherapy with  5-fluorouracil: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-20	Universidade Federal do Ceará	Centro Regional Integrado de Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-4k7zh3	<NULL>	Patients with cancer receiving chemotherapy 5-fluorouracil (5-FU) bolus as part of chemotherapy protocol at the beginning of treatment (any cycle); Patients over the age of 18;Both sexes;Patients with scores on the Glasgow scale equal to 15.	Be in radiotherapy in the head region or concomitant esophagus to chemotherapy;Possess smoking habits and alcohol during the research;Have a history of tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-55bxn5w	Application of Lactobacillus reuteri as a contributor to Dental scaling Sreatment	Recruiting	Intervention	2024-05-08	<NULL>	<NULL>	6993	Application of Lactobacillus reuteri as an adjuvant in therapy non-surgical periodontal	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-05	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-55bxn5w	<NULL>	Patients over the age of 18;Insertion Loss of 5 mm or more (Stage III of the New Classification of Periodontal Diseases) - non-adjacent interproximal teeth of hemi-arches lower anteriors; Non-smokers; Non-pregnant women; Non-lactating; Patients who agreed to take part in the research by signing the Term Free and Informed consent	Patients under 18 years of age; That does not present a loss of Insertion of 5 mm or more (Stage III of the New Classification of Periodontal Diseases) - non-adjacent interproximal teeth of lower anterior hemi arches; Smokers; Pregnant women;Nursing mothers; Patients who did not agree to sign the Free and Consent Form Enlightened	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-6ktm4zx	Application of laser to surgical wounds for breast cancer surgery	Not yet recruiting	Intervention	2023-11-22	<NULL>	<NULL>	6603	Photobiomodulation in operative wounds in breast surgery by Malignant Neoplasm	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-08	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-6ktm4zx	<NULL>	Patients over 18 years of age; diagnosed with any malignant neoplasm of the breast and who will undergo breast surgery	Patients diagnosed with benign breast neoplasia; diagnosed with bilateral malignant neoplasm; diagnostic sectorectomy; musculocutaneous flap; inflammatory T4B staging due to dermal infiltration; with tattoo or hematoma in approximately 30% of the extent of the surgical wound	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-9jp5sj	Application of light at acupuncture points in the treatment of pain in children with sickle cell disease	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2099	Application of LASER acupuncture in the treatment of pain in children with sickle cell disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-06	Núcleo de Estudo em Saúde e Funcionalidade	Hospital Universitário Professor Edgard Santos	https://ensaiosclinicos.gov.br/rg/RBR-9jp5sj	<NULL>	Patients with sickle cell disease confirmed by laboratory examination (falcization or hemoglobin electrophoresis test); report of joint pain in hematological consultation ; written proof of the authorization of the person responsible for inclusion in the study by signing a Free and Clarified Consent Term.	Previous history of fracture for a year or less, previous history of osteomyelitis, rheumatic fever, rheumatoid arthritis, leukemia, malignant neoplasm, child with cerebral palsy , making use of opioids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7n3y2gq	Application of light to treat wounds in the feet of people with Diabetes	Recruiting	Intervention	2025-02-21	<NULL>	<NULL>	7781	Study to test the application of red and blue light in the treatment of wounds in the feet of people with Diabetes	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2023-11-25	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7n3y2gq	<NULL>	Patients over 18 years old; of both sexes; already undergoing treatment for type 1 or type 2 diabetes mellitus; with a clinical diagnosis of peripheral neuropathy in the feet; having one or more active ulcers for at least 1 month; and with an ulcer of at least 1 cm² in area	Patients with end-stage chronic kidney disease/hemodialysis, heart failure grades III and IV; or other associated causes of skin ulcers (leprosy, lymphedema/elephantiasis, chronic venous insufficiency, hereditary hemoglobinopathies, squamous cell carcinoma, invasive mycoses, mycobacterioses)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-44v8y7	Application of manual therapy for painful muscle points in subjects with shoulder pain	Recruitment completed	Intervention	2018-08-20	<NULL>	<NULL>	5161	Articular Mobilization and Ischemic Compression on the Myofascial Trigger Points of Muscle Upper Trapezius in subjects with Rotator Cuff Tendinopathy: randomized clinical trial single- blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-04	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-44v8y7	<NULL>	Rotator cuff tendinopathy diagnosed by ultrasonography; present presence of non-homogeneity or partial injury of the supraspinatus tendon; both sexes; aged 25 to 65 years; have unilateral shoulder pain for at least 3 months; to present a positive result for 3 special shoulder tests of a set of 5 tests such as Neer test, Hawkins test, painfull arc test, Jobe or Empty Test, and external rotation resistance test; not be using anti-inflammatory medication for at least 1 month; not being in physiotherapeutic treatment; present upper trapezius pain in the symptomatic shoulder; as well as present 1 or more active trigger points on the symptomatic shoulder; present shoulder pain equal to or greater than 3 in resting vicsual analogic scale	Complete rotator cuff injury; have undergone surgical intervention on the shoulders; adhesive capsulitis; fibromyalgia; hematoma present in the area to be treated with capillary fragility; glenohumeral instability; pain in the cervical region; cervical radiculopathy; recent tissue repairs; unconsolidated fracture at the site to be treated; history of surgery or trauma to the spine; history of cancer; athletes who perform the sport gesture with the upper limb above the head; present neurological disease; visual and or auditory deficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-2hq36d7	Application of modified low-intensity intravascular laser in premature infants with immature lung	Other	Intervention	2020-11-27	<NULL>	<NULL>	4389	Application of modified low-intensity intravascular laser in premature infants with respiratory distress syndrome - type I	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	Hospital Universitário Regional dos Campos Gerais	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2hq36d7	<NULL>	Premature newborn with clinical diagnosis of type I respiratory distress syndrome using invasive or non-invasive ventilatory support.	Newborns with congenital neurological, heart and respiratory diseases that are not associated with RDS type I; newborns with skin lesions at the site of laser application; newborns whose parents or guardians do not sign the Informed Consent Form (ICF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-6txv3v	Application of Multidisciplinary Therapy with Electronic Means for the Obese Treatment in Adolescents.	Recruiting	Intervention	2019-04-26	<NULL>	<NULL>	2634	Application of Blended Multidisciplinary Therapy Methodology with Electronic Means for the Obese Treatment in Adolescents.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6txv3v	<NULL>	Volunteers with 14 to 19 years old; Body mass index above the 95th percentile of the curve proposed by the World Health Organization; post-pubertal Tanner Stage above five.	Genetic disease; pregnancy; previous drug utilization; chronic alcohol consumption; presence of viral hepatic diseases; other causes of liver steatosis; inability to perform physical activities; have no access to any electronic means.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-10cqv83n	Application of myofascial release aiming to prevent injuries in athletes	Not yet recruiting	Intervention	2024-05-15	<NULL>	<NULL>	7007	Myofascial release and injury prevention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10cqv83n	<NULL>	Participants must practice Taekwondo at least twice a week for two cycles; have at least 12 years old; both genders	To perform some preventive monitoring within the practice of the sport; already be injured at the beginning of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-26rcv2n	Application of Physiotherapeutic Devices in patients with Lombalgy	Not yet recruiting	Intervention	2023-11-29	<NULL>	<NULL>	6618	Application of Electrothermalphototerapeutic Current in patients with Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-26rcv2n	<NULL>	Localized lumbar pain; female and male; age 18 to 85 years; numerica pain scale (NPS more than 3; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology	pregnant women; lactating women; sedentary individuals; Body Mass Index (BMI) greater than or equal to 30 kg/m2; without physical therapy treatment simultaneously with the study period; surgery in the lumbar region; without clinical diagnosis of low back pain; not present low back pain radiating to the glutes and lower limbs; sensory alteration in the lower limbs and the use of medication to relieve low back pain 48 hours before the performance of the exercises;  neurological disease, previous diagnosis of heart disease; acute lung disease; uncontrolled hypertension beginning of medication use less than 1 year ago); orthopedic injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-2k58f5h	Application of physiotherapy equipment on Back Pain	Not yet recruiting	Intervention	2020-11-26	<NULL>	<NULL>	4754	Application of electrothermalphototerapeutic current in patients with Lumbar Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2k58f5h	<NULL>	female and male gender, aged between 18-80 years; diagnosed with nonspecific low back pain for more than 3 months; with pain numerical greater than 4.	Participants who have performed some surgery in  lumbar region; with irradiated pain; cauda equina syndrome; thermal or sensory alterations; pregnant women; spinal problems; pacemaker; skin lesions and use of medication for relief of low back pain 48 hours before the application; skin diseases; especially at the current site of application; History of tumors or cancer in the last 5 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-5jt8k2	Application of physiotherapy to reduce pressure	Recruitment completed	Intervention	2018-12-07	<NULL>	<NULL>	2370	Comparative analysis between two antihypertensive manual techniques: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-27	Faculdade Independente do Nordeste - FAINOR	Faculdade Independente do Nordeste - FAINOR	https://ensaiosclinicos.gov.br/rg/RBR-5jt8k2	<NULL>	Be over 18 years old; has high BP; not presenting decompensated cardiovascular pathologies or neurological sequelae due to stroke; ability to respond to the questionnaire.	Ocular infections; use of normopressoric drugs in an infusion pump; severe pain&gt; 7	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-106yjkc3	Application of Telecare technologies in patients with Temporomandibular Disorders and Bruxism	Recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8081	Use of Teleassistance tools in the care of individuals with Temporomandibular Disorders and Bruxism	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Programa de Pós Graduação em Odontologia da Universidade Federal do Paraná	Setor de Ciências da Saúde da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-106yjkc3	<NULL>	Over eighteen years of age; both genders; any ethnicity; who contact the temporandibular disorder and orofacial pain service at the Federal University of Paraná	Minors under 18 years of age; participants who do not have time for the appointments at the University clinic at the scheduled times; psychological or mental abnormalities that may prevent collaboration and completion of the questionnaires; participants who do not have access to a smartphone with the WhatsApp application installed; people who have previously received a clinical assessment of temporomandibular disorder and orofacial pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-4r26fz	Application of the knowledge, skill and attitude questionnaire regarding the Monitors used in the Intensive Care Unit	Data analysis completed	Intervention	2019-07-24	<NULL>	<NULL>	2848	"Application of cha inventory (knowledge, skill and attitude) and intervention,
the use of multiparametric monitors in an intensive care unit"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Triângulo Mineiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-4r26fz	<NULL>	The entire nursing team (nurses and technicians) was included in the survey, which currently comprises the staff of the chosen services. Thus the inclusion of all the team was intentional, considering the particular characteristics of the study group. For this purpose, they agreed to participate in the study, by signing the Term of Clarification for the participants, as well as the Free Consent Form after Clarification for Participants prepared according to Resolution 466/12 of the National Health Council (BRAZIL, 2012).	Those who were on maternity leave and leave were excluded from the study. As the forecast for the data collection was three months in some situations it was not possible to wait for the return of employees who were away for health or maternity leave. Those professionals who were reassigned from sectors, dismissed or did not participate in all stages of the research (regarding pre- and post-intervention) were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-5x4cvd9	Application of the mini-questionnaire on quality of life in individuals with high blood pressure (minichal) during the covid-19 pandemic	Recruiting	Intervention	2021-02-12	<NULL>	<NULL>	4552	Application of the quality of life mini-questionnaire in arterial hypertension (Minichal) during the covid-19 pandemic	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-03	UNISEPE - Uniao Das Instituicoes De Servico Ensino e Pesquisa	UNISEPE - Uniao Das Instituicoes De Servico Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-5x4cvd9	<NULL>	Individuals diagnosed with SAH; between 20 and 70 years of age; of both sexes; and signing the informed consent form.	Volunteers of both sexes with decompensated SAH.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-359xvj	Application of transcutaneous electrical nerve stimulation in individuals with temporomandibular dysfunction	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2675	Transcutaneous electrical stimulation in TMD analgesia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-13	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-359xvj	<NULL>	Men and women; aged between 18 and 55 years; who presented signs and symptoms of temporomandibular myogenic dysfunction	Do not present pain in the masticatory musculature, history of systemic rheumatic disease, or were taking analgesic and / or anti-inflammatory drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-9vcph8x	Application of Whole Body Red Light in patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2024-05-08	<NULL>	<NULL>	6996	Whole-body photobiomodulation of patients with Chronic Obstructive Pulmonary Disease, randomized crossover, single-blind, sham-controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-23	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9vcph8x	<NULL>	Patients of both sexes; over forty years of age  forty years or older; with a clinical diagnosis of Chronic Obstructive Pulmonary Disease - COPD; classified by Chronic Obstructive Lung Disease GOLD as moderate and severe; clinically stable; non-smokers and former smokers; without exacerbations in the last four weeks; and who have not participated in any application of whole-body light	Patients who present exacerbation of symptoms in the four weeks prior to the collections; those with spinal cord trauma that prevents the tests from being performed; chronic neurological disorder; progressive neuromuscular disease; recent cancer treatment; symptoms of exertion intolerance at baseline such as: respiratory rate greater than 35 breaths per minute, signs of respiratory distress, use of accessory muscles, paradoxical breathing, saturation less than 85 and heart rate greater than 120 beats per minute at rest and breathing in room air	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-4pgn3c	Applications of one Physioterapy Equipment in Low Back Pain	Not yet recruiting	Intervention	2020-01-15	<NULL>	<NULL>	3374	Aussie current application in low back pain patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4pgn3c	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than 3 ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	Participants who have had surgery in the lower back;  not presenting back pain radiated to the buttocks and lower limbs, alteration of thermal and / or sensory sensitivity, pregnant women, kidney problems; patients with pacemakers; skin lesions; use of medication for lumbar pain relief 48 hours before the application of the technique. do not have clinical diagnosis of low back pain and when the etiology of back pain is unknown.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-59ygr8	Applications of physioterapy equipments in low back pain	Recruiting	Observational	2016-06-14	<NULL>	<NULL>	1026	Application of electrothermotherapies resources in patientes with lumbar pain	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-59ygr8	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	"Physical activity people with more than 6 weeks
It has been realized lumbar surgery; it not have clinical diagnosis of lumbar pain and when the ethiology was not known; it don´t show irradiated lumbar pain to gluteus and lower limbs, thermic and sensibility alteration, pregnant woman, kidney problem; patients with pace marker; skin lesions; patients who utilized analgesic medication before 48 hours of application of resource."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-98hj9x	Applications of Physioterapy Equipments in Low Back Pain	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	3369	Application of Electrothermalphototerapeutic Current in patients with Lumbar Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-98hj9x	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	Participants who have had surgery in the lower back; gives; not presenting back pain radiated to the buttocks and lower limbs, alteration of thermal and / or sensory sensitivity, pregnant women, kidney problems; patients with pacemakers; skin lesions; use of medication for lumbar pain relief 48 hours before the application of the technique. do not have clinical diagnosis of low back pain and when the etiology of back pain is unknown.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-69dnfz	Applying ICDAS  to decrease of the disallowance rate in Dental Care Delivery Systems	Data analysis completed	Intervention	2019-07-19	<NULL>	<NULL>	2828	Application and effects of ICDAS in Dental Audit	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2014-10-01	Dentistry School of Piracicaba. State University of Campinas (FOP-UNICAMP)	Dentistry School of Piracicaba. State University of Campinas (FOP-UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-69dnfz	<NULL>	Dentists/auditors who worked in the accredited network for more than 1 year; who had professional experience of over 10 years; who freely accepted to participate in this study; dentists who performed large quantities of dental caries treatments in the dental care delivery system, before and during the study.	Dentists/auditors who were invited but who did not agree to participate in the study; dentists who did not perform caries treatments after receiving the training; dentists who participated in the training but did not reach an acceptable level of concordance regarding ICDAS (weighted Kappa Index equal to or greater than 0.75).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-5j2cd8q	Aquatic exercise and multimorbidity: Analysis of mental health parameters, cognition, functional autonomy, muscular efficiency and oxidative dysfunction induced by different HIIT models in the elderly	Recruiting	Intervention	2024-08-17	<NULL>	<NULL>	7230	HIIT in elderly people with multimorbidity: effects on psychophysiological health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-10	Universidade do Extremo Sul Catarinense - UNESC	Universidade do Extremo Sul Catarinense - UNESC	https://ensaiosclinicos.gov.br/rg/RBR-5j2cd8q	<NULL>	1) be over 60 years of age; 2) present a medical certificate showing the three associated multimorbidities (hypertension, diabetes and depression); 3) present a medical certificate authorizing aquatic physical exercise; 4) both genders	1) have any clinical impediment to physical exercise certified by a doctor; 2) have any other type of pathology, associated or not, that could interfere with the results of the study; 3) not present the documents requested; 4) not be over 60 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-7zxk77	Aquatic exercises and health education for the treatment of fibromyalgia	Data analysis completed	Intervention	2016-05-21	<NULL>	<NULL>	856	Hydrotherapy and health education for the treatment of fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Centro Universitário de Formiga - MG (UNIFOR-MG)	Centro Universitário de Formiga - MG (UNIFOR-MG)	https://ensaiosclinicos.gov.br/rg/RBR-7zxk77	<NULL>	women who have a confirmed diagnosis of fibromyalgia by a physician and according to the new diagnostic criteria proposed by the American College of Rheumatology in 2011. Regardless of race; aged between 25 and 60 years; BMI below 30; who read and sign the Consent and Informed (IC) not using drugs for more than three months or with stable pharmacological treatment for more than three months.	women who did not sign the consent form; which violate the data collection protocol; which change the drugs during the study period; using steroidal anti-inflammatory drugs or nonsteroidal; pregnant women; nursing mothers; patients with a history or presence of cancer or diseases autoimmune; psychiatric; infectious and inflammatory or in the period of data collection or in the three months prior to data collection will also excluded patients who do not participate in at least 80% of the activities proposed by the researchers (EIF and Hydrotherapy).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-5n82tv	Aquatic Physiotherapy for Hospitalized Premature Newborns	Recruitment completed	Intervention	2017-10-10	<NULL>	<NULL>	5788	Effectss of Hydrotherapy in Buckets in Preterm Newborns in a Neonatal Unit Care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-15	Universidade Federal de Mato Grosso do Sul (UFMS)	Universidade Federal de Mato Grosso do Sul (UFMS)	https://ensaiosclinicos.gov.br/rg/RBR-5n82tv	<NULL>	Preterm newborns with gestational age at birth equal to or less than 32 weeks; with more than 72 hours postnatal life; hospitalized in NICU; with stable clinical condition; without central or peripheral venous access; without need of invasive or non-invasive mechanical ventilation.	Newborns with congenital malformations, chromosomal syndromes; infections in treatment (change in blood count and positive blood culture); severe neurological injury (intracranial hemorrhage grade III or IV and cerebral malformations); neonatal anoxia; congenital infections and skin lesions with risk of contamination; with other contraindications to immersion in warm water.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-78h48d	Aquatic physiotherapy in pain, daily activities and quality of life in older people with knee Osteoarthritis	Recruiting	Intervention	2016-01-29	<NULL>	<NULL>	700	Effectiveness of aquatic physiotherapy in the perception of pain, functional capacity and quality of life of older adults with knee Osteoarthritis: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-23	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-78h48d	<NULL>	Volunteers diagnosed with knee osteoarthritis; both genders; age above 60 years.	Volunteers with severe cardiac and respiratory diseases; fibromyalgia; epilepsy; knee replacement or hip; inability to walk independently; otitis; sores on the skin; mycoses; hydrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-9dgk5r	Aquatic therapy on muscle strenght and quality of life in elderly women	Recruitment completed	Intervention	2016-07-14	<NULL>	<NULL>	922	The influence of aquatic physical therapy program on muscle srenght and quality of life in elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-10	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-9dgk5r	<NULL>	Volunteers aged over 60 years; that did not show any functional impairment and cardiorespiratory disease that is restrictive for the implementation of the program of aquatic exercise.Additionally, the volunteers should not participate in other programs of regular exercise.	Volunteers who present  the following contraindications for aquatic exercise program; otitis; hydrophobia; sores on the skin; mycoses and hypertension stage III.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-643vk9t	Aquatic training for type 2 diabetes	Recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8721	Physical training in an aquatic environment for the control of type 2 diabetes	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-02	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 35 and 90 years; diagnosis of type 2 diabetes confirmed by laboratory tests or use of hypoglycemic drugs; presentation of a medical certificate authorizing physical exercise; participation in the Physical Training in Aquatic Environments Extension Project for the Control of Type 2 Diabetes	As exclusion criteria, participants cannot have uncontrolled hypertension; be without medical treatment for diabetes; or have clinical, joint, or muscle impairments that prevent them from exercising safely	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-104sqkyp	Are there relationship between the amount of creatine in the diet and memory in the elderly?	Recruiting	Observational	2022-06-03	<NULL>	<NULL>	5416	Are there correlations between the amount of creatine in the diet and short-term visuospatial memory in the elderly? The observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-05	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-104sqkyp	<NULL>	Elderly more than 60 years old; physically active; healthy; both genres	Elderly people with cognitive impairment (MMSE more than 20); who use nutritional supplements; who are illiterate; or who use medications that affect cognition cannot participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-3hf6gyw	Aromaterapia inalatória com lavanda para redução da ansiedade	Recruitment completed	Intervention	2025-03-18	<NULL>	<NULL>	7845	Pilot study for clinical application protocol of inhaled aromatherapy with lavender for anxiety reduction: a randomized double-blind placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-08	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3hf6gyw	<NULL>	Age between 18 and 30 years; with an anxiogenic trait and medium anxiety state (with scores between 30 and 39 on the State-Trait Anxiety Inventory/ STAI); who smell odors.	Being chemically dependent, or using anxiolytics, antidepressants, antihistamines, narcotics; being allergic to odors/smells, or undertaking some other complementary therapy for stress/anxiety relief such as meditation or yoga; People who meet the diagnostic criteria for Generalized Anxiety Disorder, Obsessive Compulsive Disorder, Major Depressive Disorder and Attention Deficit Disorder, according to the Structured Clinical Interview for Disorders screening strategy of DSM-5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-82c8gr7	Aromatherapy foot bath: a randomized trial for Depression, Anxiety, and Minor Disorders	Not yet recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8363	The use of Complementary Integrative Practices, PIC&apos;s, in the municipality of Londrina, UEL, city hall of Londrina	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-82c8gr7	<NULL>	trabalhadores da saúde que atuam direta e indiretamente com o cuidado do paciente, que atuam em um hospital terciário	Retired workers or those with planned and unplanned absenteeism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-7bmw7t2	Aromatics for controlling dental anxiety in children: a clinical study	Recruitment completed	Intervention	2024-12-20	<NULL>	<NULL>	7621	Aromatherapy in the management of dental anxiety in pediatric dental patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7bmw7t2	<NULL>	Parents and/or guardians authorize the child to participate in the research. Children who score between 5 and 8 on the modified Venham Pictures Test scale. Children without health impairment. Children with the intellectual capacity to answer questions. Patients between 6 and 12 years of age. Both genders	Children with allergies. Children with cognitive difficulties. Children with systemic impairments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-6pjw7g8	Art as a therapeutic resource for alleviating anxiety in elderly residents of long-term care facilities	Not yet recruiting	Intervention	2026-02-04	<NULL>	<NULL>	8826	Art therapy as a tool for reducing Anxiety levels in elderly people living in long-term care facilities: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Cruzeiro do Sul Educacional S.A	<NULL>	<NULL>	<NULL>	Moderate or high levels of anxiety; no cognitive impairment; assessed by the Mini-Mental State Examination (MMSE); no hemodynamic instability; willingness to participate in all intervention sessions; no severe sensory alterations	Elderly individuals with severe communication impairments; Diagnosis of advanced neurodegenerative diseases; Previous and regular participation in art therapy practices; Under pharmacological treatment for anxiety; With severe behavioral changes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-8drccq	Art treatment as a option to restorative approach to Molar Incisor Hypominerlisation	Recruitment completed	Intervention	2016-12-12	<NULL>	<NULL>	1099	Art treatment as a option to restorative approach to Molar Incisor Hypominerlisation	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8drccq	<NULL>	Parents assignature (TCLE); children with good health conditions; children with MIH molar and incisor teeth with dentin breakdown by caries, no pulp involvement.	Children no cooperation during the treatment; children with no good health conditions; when parentes did not sign the TCLE; children teeth that needs extraction or endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-6dyvm4	Arthrocentesis associated with infiltration of hyaluronic acid or platelet-rich plasma improve interincisal mouth opening and painful  in the region of  temporomandibular joint	Recruiting	Intervention	2020-05-21	<NULL>	<NULL>	3856	Does arthrocentesis associated with infiltration of hyaluronic acid or platelet-rich plasma improve interincisal mouth opening and painful symptoms in temporomandibular joint disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6dyvm4	<NULL>	patients between 18 and 67 years old; diagnosed with arthralgia, disc displacement or degenerative joint diseases;with a minimum of 4 points on the visual and numerical analogue pain scale (NAVS) in the articular region; maximum interincisal opening less than or equal to 35 mm.	previous history of TMJ surgery; indication for surgical treatment; systemic conditions involving ATM;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-24y9dd	Arthrocentesis vs nonsurgical methods in the treatment of temporomandibular joint pain and closed lock. A randomized controlled trial	Recruitment completed	Intervention	2020-01-06	<NULL>	<NULL>	3335	Does the association of Nsaids whit arthrocentesis for 30 days improve the mouth opening and painfull symptoms in temporomandibular joint dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-07	Faculdade de Odontologia da Universidade Estadual do Rio de Janeiro	Faculdade de Odontologia da Universidade Estadual do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-24y9dd	<NULL>	Patients older than 18 years and younger than 67; presenting at least 4 points corresponding to joint pain in the visual analogue scale (VAS); with mouth opening  at less or equal than to 35 mm; with a history of joint locking;  progressive decrease of mouth opening and joint noises	History of TMJ surgery or with an absolute indication of surgical treatment; joint systemic diseases; gastric disease or other condition that contraindicate the use of NSAIDs; muscular pain as the main source of the symptomatology and patients with psychological compromises that would make treatment impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7c7ndt	Arthrotomy versus arthroscopy in the treatment of septic arthritis in adults knee joint: a randomized clinical trial with a 24-month follow-up	Data analysis completed	Intervention	2015-04-29	<NULL>	<NULL>	458	Open approach versus Arthroscopy surgery in the treatment of articular infection of the knee in adults: a randomized clinical trial with a 24-month follow-up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-01	Casa de Saúde Santa Marcelina	Casa de Saúde Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-7c7ndt	<NULL>	Knee septic arthritis confirmed by clinical and laboratorial exams, and age (patients aged 16 years or more were included). The clinical exam was considered positive for infection when there was pain, hyperemia, local warmth, joint swelling, or limited movement in walking. Synovial fluid collection by puncturing at admittance allowed diagnosis confirmation.	Patients with chronic septic arthritis, i.e., for more than 15 days, fractures, chronic wounds or ulcers in the knee, septic diseases affecting more than one joint, morbidities affecting the ability to walk or to move the knee. Allergic patients or those who could not receive the standard antibiotic therapy for any reason were also excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-2z3f7k	Artificial ventilation setting in patients infected with COVID-19	Recruiting	Intervention	2020-05-04	<NULL>	<NULL>	4158	Individualized PEEP setting in patients with Acute Respiratory Distress Syndrome: ventilatory strategy in the COVID-19 pandemia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-29	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-2z3f7k	<NULL>	Age 18 to 80 years; Mechanically ventilated patients with   COVID-19 infection suspicious	"Pregnancy confirmed by laboratory tests;
• Weight below 35 kg; Patients undergoing endotracheal intubation as a result of exacerbation of chronic lung disease; Radiological aspects compatible with pulmonary fibrosis, consolidation of the lung parenchyma, tumor masses and emphysema; Patients with pneumatocele; Pneumothorax, subcutaneous emphysema and pneumomediastinum documented and not resolved; Patients with heart failure previously classified as functional class III or IV according to the New York Heart Association (NYHA); Patients with acute coronary syndrome or persistent ventricular tachyarrhythmias; Mean arterial pressure (MAP) less than 65 mmHg with a dose of norepinephrine 0.5 to 1.0 mg / kg / min; Acute brain injury or high intracranial pressure, that is, greater than 18 mmHg;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-3cwrdv	Asperisation of the dental cavity to improve the adhesion of composite resin restorations in patients with proximal teeth lesions of the gingiva	Not yet recruiting	Intervention	2018-02-27	<NULL>	<NULL>	1662	Asperisation of the dental cavity to maximize the adhesion of Composite Resin Restoration in patients with Non-Carious Cervical Lesions (LCNC) - using a Universal Adhesive System in the conventional and self-etching mode: Double Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-25	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3cwrdv	<NULL>	Patients older than 18 years will be included; presence of at least four LCNCs per patient, regardless of their location in the dental arch; adequate oral hygiene, and absence of driving difficulties that prevent adequate oral hygiene; absence of periodontal disease, active carious lesions and parafunctional habits, at least 20 teeth in function; absence of active staples of removable partial dentures in the teeth included in the research, and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Will be excluded: patients who do not agree with the terms of the survey; patients who do not feel motivated to participate in the research and maintain oral hygiene; patients who have difficulty attending the posterior controls of the restoration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-9nv2h42	Assessing brain health in adults and older adults	Recruiting	Observational	2022-05-24	<NULL>	<NULL>	5403	Characterization of normality curves of non-invasive intracranial pressure in adult and elderly individuals	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-18	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9nv2h42	<NULL>	Age between 25 and 60 years for the adult group and over 60 and up to 80 years for the elderly group; healthy; through confirmation by blood count and biochemical examination; and do not use controlled medications.	Idiopathic intracranial hypertension; chronic diseases (hypertension; cardiovascular or metabolic diseases; arrhythmias; migraine; cerebrovascular or neurodegenerative diseases and genetic diseases); present risk factors for cardiovascular diseases (BMI&gt;30 kg/m²; LDL&lt;130 mg/dl; smoker; alcoholic; substance abuser or waist circumference greater than 94 cm for men and 80 cm for women, according to recommendations of the Brazilian Ministry of Health ).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-2j778gq	Assessing depression, anxiety, stress, loneliness, drug use and communication skills in college students to develop interventions that help them	Recruitment completed	Intervention	2024-06-14	<NULL>	<NULL>	7070	Emotional symptoms, loneliness, drug use, assertiveness in university students: from evaluation to intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-2j778gq	<NULL>	Being at leats 18 years-old; both genders; being enroled at a Brazillian institution in an undergraduate course	Presenting psychotic symptoms; excessive use of drugs; and/or having suicidal or self-harming ideation or behavior	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-6d3g5hp	Assessing Mineral Gain of a Remineralizing Toothpaste in Teeth with Molar Incisor Hypomineralization (MIH)	Recruitment completed	Intervention	2025-10-30	<NULL>	<NULL>	8485	Evaluation of the remineralizing effect of a Silicon-Enriched Toothpaste on teeth with Molar Incisor Hypomineralization (MIH): a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-20	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Children aged 6-12 years; with fully erupted permanent central and lateral incisors; with MIH lesions of any severity level diagnosed by a trained dentist according to the criteria established by Ghanim et al. (2017).	Children with syndromes; children undergoing orthodontic treatment with fixed appliances; previously restored or treated permanent incisors; presence of other enamel defects such as dental fluorosis/hypoplasia.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:35
RBR-74jtvm	Assessing the effect of a web-based psycotherapy for alcoholists	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	664	Web-based brief psychotherapies for users alcohol and other drugs	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-74jtvm	<NULL>	male; alcohol dependent diagnosis; between 18 and 65 years; not be abstinent during 30 days prior to admission to treatment	abuse or dependent diagnosis of other drugs, exception of tobacco; have participated in specialized treatment for alcohol and other drugs problems in the last three months; meet criteria for severe mental disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-5jfjx9	Assessing the Effect of Vitamin C Replacement as an Auxiliary Treatment for Anemia in Chronic Kidney Patients on Hemodialysis	Recruitment completed	Intervention	2020-08-24	<NULL>	<NULL>	4150	Efficacy of ascorbic acid as adjunctive therapy in the treatment of anemia in chronic renal patients undergoing hemodialysis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Faculdade de Ciências Médicas	Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-5jfjx9	<NULL>	Be part of a hemodialysis program for chronic kidney disease; Be on erythropoietin in any dose, to control anemia of chronic kidney disease; Perform at least three weekly hemodialysis sessions, with a minimum duration of 4 hours each session; Be assiduous at hemodialysis sessions	Do not use any therapies to control anemia of chronic kidney disease; Be a minor; Chronic ascorbic acid use; Failure of vascular access, such as catheters with low blood flow that prevent hemodialysis with flow above 250 ml / min; Critical worsening of health status, such as prolonged hospitalizations in intensive care units, patients undergoing major surgery with prolonged recovery or patients in palliative care for malignant neoplasms; Little attendance with frequent absences from hemodialysis sessions or undergoing hemodialysis during reduced hours or reduced doses; Any acute or chronic condition that limits the patient&apos;s ability to participate in the study, such as advanced heart or liver disease; Have a kidney transplant or recover kidney function in the middle of the study; Malnourished patients, with low body weight, those who use immunosuppressants, chemotherapy, antivirals or immunobiologicals; Patients with a hypersensitivity reaction to some of the research components, such as ascorbic acid or erythropoietin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-7cps9tt	Assessing the impact of combining Acupuncture with Anti-nausea and Anti-vomiting medications in patients undergoing Chemotherapy treatment	Recruitment completed	Intervention	2024-12-02	<NULL>	<NULL>	7554	Evaluation of the effect of Acupuncture combined with antiemetics in the prophylaxis of Chemotherapy Induced Nausea and Vomiting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Faculdade de Medicina de São José do Rio Preto	Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-7cps9tt	<NULL>	Female gender; Age &gt; 18 years; Diagnosis of Primary Breast Cancer; Undergoing AC Chemotherapy protocol (Doxorubicin + Cyclophosphamide)	Age &lt; 18 years; Illiteracy; presence of another Primary Cancer; presence of Metastasis; presence of Skin Lesions/Inflammations at the needling site; patient refusal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-99qqhf	Assessment and rehabilitation of patients with knee pain	Recruiting	Intervention	2017-06-29	<NULL>	<NULL>	1272	Assessment of Patelofemoral Pain Syndrome patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-99qqhf	<NULL>	Pain at least for a month. No relation with accident. Insidious onset. Positive tests for patellofemoral pain. Female. Between 18 and 30 years old.	Specific diseases of the knee. Knee surgery. Knee treatments or physiotherapy during the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-5pg989	Assessment and treatment of shoulder Pain	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2059	Assessment and intervention of shoulder Dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-20	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5pg989	<NULL>	"Category 1 volunteers will be included, adults 18 and older, of both sexes; patients with shoulder pain associated with range of motion limitation; we will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; non-athletes or regular physical activity practitioners who perform aerial launch movements; pregnant or reporting pregnancy will not be included; Acceptance in the Informed Consent Form.

Category 2 volunteers will be included, adults 18 and older, of both sexes; patients with shoulder pain associated with range of motion limitation; we will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; athletes practicing regular physical activity that perform aerial launch movements; Acceptance in the Informed Consent Form.

Volunteers will be included for category 3, adults over 18 years of age, female; volunteers with complaints of wrist and hand pain with irradiation in the upper limb diagnosed as compressive syndrome will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; non-athletes or regular physical activity practitioners who perform aerial launch movements; pregnant or reporting pregnancy will not be included; Acceptance in the Informed Consent Form."	Participants who do not attend the reevaluations, do not carry out the proposed home protocol will be excluded; failure to complete the questionnaires; unable to perform the proposed exercises on the first day of the assessment; discomfort during the performance of exercises such as dizziness and nausea.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-6xqcr4	Assessment cardiorespiratory  in recovered Covid-19 patients	Recruiting	Observational	2020-07-10	<NULL>	<NULL>	4001	Cardiorespiratory fitness and neuromuscular performance in recovered Covid-19 patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	LETFAS-UFPB	LETFAS-UFPB	https://ensaiosclinicos.gov.br/rg/RBR-6xqcr4	<NULL>	Patients recovered from Covid-19 with mild to severe severity (recovery within 30 days) and people not contaminated by the coronavirus; both sexes; non smokers; 18 years old or older	Smoking volunteers; pregnancy; morbid obesity; diagnoses of cardiac, pulmonary, hematological, neurological or neuromuscular diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-4hmrph	Assessment in humans of aesthetics and functions of common implants restored with crowns and porcelain metal crowns and porcelain only	recruitment completed	Intervention	2012-01-31	<NULL>	<NULL>	67	Comparative analysis of aesthetic and functional parameters of implant abutments using ceramic and metallic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4hmrph	<NULL>	"of both genders, 
without regard to race, 
aged 18 years and 
need for rehabilitation with crowns and bridges up to two elements of the implant in the anterior region, totaling sixty sites for implants ."	"smoking, 
with systemic diseases, 
need for bone grafting and 
parafunctional habits."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-10ppxgw6	Assessment of  antibodies protection formation  in chronic non-cirrhotic Hepatitis C carriers after being exposed to two Hepatitis B vaccine regimens	Recruitment completed	Intervention	2021-07-16	<NULL>	<NULL>	4790	Assessment of Anti-HBV Immunogenicity in chronic Hepatitis C non-cirrhotic  carriers after being exposed to two Hepatitis B vaccine regimens	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-26	Faculdade de Medicina da Universidade de São Paulo	University of California San Francisco (UCSF), San Francisco, USA.	https://ensaiosclinicos.gov.br/rg/RBR-10ppxgw6	<NULL>	GROUPS A and B: chronic C hepatitis carriers; age similar or superior to 18 years; absence of cirrhose; infection documented by VHC (antiVHC quantitative PCR for VHC); patients non immunized against VHB; availability to collect blood samples after the administration of the anti HBV for analysis. GROUP C: health controls; age similar or superior to 18 years; patients non immunized against VHB; health individuals with negative serologies to VHB and VHC; availability to collect blood samples after the administration of the antiHBV for analysis.	Age above 18 years old; presence of cirrhose; absence of Infection documented by C virus in the selected patients for A and B groups; patients previously immunized against VHB; impossibility to collect blood samples after the administration of the antivaccine HBV for analysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:40
RBR-77qc49q	Assessment of  the female intimate area before and after the use of treated and untreated pantyliners	Recruitment completed	Intervention	2023-11-01	<NULL>	<NULL>	7569	Single-center, parallel, single blind clinical study to evaluate the urogenital microbiota and skin condition before and after wearing treated pantyliners with prebiotic and untreated control pantyliner (E003417A)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-07	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	https://ensaiosclinicos.gov.br/rg/RBR-77qc49q	<NULL>	Females; 18 to 45 years old; in good general health; with regular monthly menstrual cycles that are not expected to menstruate during the study; participants must have healthy and intact skin in the test areas, and be willing to comply with study requirements	Participants that are pregnant or intending to become pregnant during the study, or breast-feeding; participants that have a history of skin conditions or the presence of visible skin conditions on any skin testing sites; history of chronic or currently active gynecological pathologies or urogenital infections in the last 3 months; used systemic and/or topical antibiotics, antifungals, and/or corticosteroids within 4 weeks prior to visit 1 and throughout the study; any other medical condition or history that may compromise the study results or the subject’s safety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-5g4p9q8	Assessment of a cryotherapy crpotocol on the occurrence of postoperative endodontic pain in molars with irreversible pulpitis: a randomized clinical trial	Recruiting	Intervention	2024-04-29	<NULL>	<NULL>	6978	Assessment of a cryotherapy protocol on the occurrence of postoperative endodontic pain in molars with irreversible pulpitis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-04	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5g4p9q8	<NULL>	The inclusion criteria will involve recruiting capable adult patients (18 to 65 years old) who already have an indication for endodontic treatment in permanent molars, diagnosed with irreversible pulpitis confirmed by a positive response to clinical, electrical sensitivity, and radiographic tests. Individuals participating in this research must provide a contact number (phone, cell phone, or social media username) to facilitate postoperative assessments. If a patient requires endodontic treatment for more than one tooth, the operator will follow the standard protocol; however, such cases will not be included in the study to avoid selection bias in the sample.	"Patients in any stage of pregnancy, those currently taking medication such as analgesics or anti-inflammatories at the time of treatment, immunocompromised individuals, or those with hypersensitivity to non-steroidal anti-inflammatory drugs will not participate in the study. These factors may alter pain perception or interfere with the analysis of post-treatment pain scores.

Patients with teeth presenting endodontic complications, such as calcifications, external or internal resorption, partial apex formation, dental perforations, longitudinal or vertical fractures, severe periodontal disease, or those undergoing treatment in multiple sessions, will also be ineligible for participation in this study. These factors can interfere with proper endodontic therapy and, consequently, with postoperative pain. Data from patients who cannot be contacted for postoperative pain assessment for any reason will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-849jyv	Assessment of a home exercises program with HAM/TSP individuals	Recruitment completed	Intervention	2015-11-14	<NULL>	<NULL>	651	Assessment of a home exercises program with HAM/TSP individuals - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-05	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-849jyv	<NULL>	Individuals with diagnosis of HTLV-1 by ELISA and confirmed by Western Blot test. Have definitive diagnosis of HAM / TSP established according to the diagnostic criteria proposed by the World Health Organization. Having aged 2 to 59 years. Being able to stand. Subscribe to the free and informed consent.	Patients suffering from rheumatic diseases. Patients suffering from orthopedic diseases. Patients suffering from other neurological diseases. Patients with cognitive changes that compromise the understanding of the exercise program and evaluation tools used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-5753p8c	Assessment of acceptance and self-assessment of a nasal spray	Not yet recruiting	Intervention	2023-02-05	<NULL>	<NULL>	5867	Assessment of acceptance in use and self-assessment of a nasal spray (094840-01) under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-31	Allergisa Pesquisa Dermato-Cosmetica Ltda	Allergisa Pesquisa Dermato-Cosmetica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5753p8c	<NULL>	Healthy pediatric subjects; Intact skin on test site; Agreement of the child&apos;s legal guardian to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; Ability by the guardian of consenting to the participation of the child in the study; Children aged from 6 months to 2 years and 11 months; Study subjects of any gender. Subjects presenting phototype (Fitzpatrick) I to IV;Users of products of the same category.	Skin pathology on the area of product application; Diabetes; Immunological insufficiency.Current use of the following topical or systemic medications: corticosteroids, immunosuppressant and anti-histaminic drugs.Skin diseases: vitiligo, psoriasis, atopic dermatitis; History of reaction to the category of product tested; Other diseases or medications that might directly interfere with the study or put subject&apos;s health under risk.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-6f2q3my	Assessment of acceptance in use and self-assessment under normal use conditions	Not yet recruiting	Intervention	2023-02-05	<NULL>	<NULL>	5866	Assessment of acceptance in use and self-assessment by the pediatric subject of the study (100222-01), under normal use conditions	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-31	Allergisa Pesquisa Dermato-Cosmetica Ltda	Allergisa Pesquisa Dermato-Cosmetica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-6f2q3my	<NULL>	Healthy pediatric subjects; Intact skin on test site; Agreement of the pediatric subject&apos;s legal guardian to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; Ability by the guardian of consenting to the participation of the pediatric subject in the study; Aged between 2 and 12 years old; Study subjects of any gender; Subjects presenting phototype (Fitzpatrick) I to IV; Users of products of the same category	Skin pathology on the area of product application;Diabetes; Immunological insufficiency; Current use of the following topical or systemic medications: corticosteroids, immunosuppressant and anti-histaminic drugs; Skin diseases: vitiligo, psoriasis, atopic dermatitis; History of reaction to the category of product tested; Other diseases or medications that might directly interfere with the study or put subject&apos;s health under risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-775y3d	Assessment of adherence to the guidelines for the management of Obesity in patients in the line for Surgery to Reduce the Stomach	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	1635	Assessment of adherence to the guidelines for self-management of Obesity in patients in the waiting line for Bariatric Surgery in SUS: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Estadual Paulista `` Julio de Mesquita Filho´´ Faculdade de Ciências Farmacêuticas, Câmpus Araraquara	Fundação Faculdade Regional de Medicina de São José do Rio Preto- FUNFARME / Hospital de Base	https://ensaiosclinicos.gov.br/rg/RBR-775y3d	<NULL>	Patients with indications for bariatric surgery; aged between 18 and 65 years.	patients that are receiving care or guidance from other services for weight loss; history of alcohol or drug abuse; inflammatory cardiovascular disease in the active phase; chronic kidney disease; active cancer; severe cardiovascular disease; chronic obstructive pulmonary disease; systemic arterial hypertension that do not use medication for control; untreated thyroid disorders; severe functional limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-3z3fcdk	Assessment of Anxiety in Dental Surgeries	Recruitment completed	Intervention	2024-04-22	<NULL>	<NULL>	6954	Assessment of Anxiety in Third Molar Surgery Controlled split-mouth clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-05	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Instituto de Ciência e Tecnologia - Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-3z3fcdk	<NULL>	Patients requiring extraction of bilateral lower third molars; of both genders; aged between 15 and 40 years; bilateral teeth, 38 and 48 with the same inclusion classification as Winter, Pell and Gregory; participate voluntarily; sign the Free and Informed Consent Form	Patients with systemic diseases, hypertensive, diabetic, depressive, cardiac; with the use of medications for anxiety, depression, panic syndrome; using anti-inflammatory drugs in the last 15 days; with the use of analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-344jq8	Assessment of applicability and results of nerve electrical stimulation in the treatment of children with intractable intestinal constipation	Recruiting	Intervention	2018-03-13	<NULL>	<NULL>	1685	Evaluation of applicability and clinical outcomes transcutaneous electrical nerve stimulation posterior treatment of children with constipation intractable intestinal	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Medicina de Botucatu-FMB/UNESP	Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Medicina de Botucatu-FMB/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-344jq8	<NULL>	Patients between the ages of 7 and 18 years of age, of both sexes, with a diagnosis of CIC, established according to the criteria of Rome IV, and classified as having intractable intestinal constipation, according to the definition of the European Societies ( ESPGHAN) and North American (NASPGHAN) Gastropediatrics, represented by patients unresponsive to standard treatment, after a period of threE months	"Patients whose parents and / or guardians do not agree to participate in the study and who do not sign the Free and Informed Consent Term, as well as patients between the ages of 12 and 18 who do not sign their consent form, will be excluded. Patients with any identifiable organic cause for intestinal constipation will be excluded from the study. Exclusion criteria will also be considered: neurological and / or cognitive deficits, skin lesions in the region of application of electrodes, changes in local sensitivity, presence of cardiac pacemaker, children presenting with cardiac arrhythmias or cardiac arrhythmias, patients presenting incomplete questionnaires or that are subject to drug changes and the standard
during the intervention period or who abandon the proposed electrostimulation treatment during the intervention period"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-25ck6t	Assessment of balance and muscle function in elderly women with osteoporosis after exercises with vibratory rod	Data analysis completed	Intervention	2016-01-29	<NULL>	<NULL>	801	Analysis of functional balance and electromyographic activity of elderly women with osteoporosis submited of balance training with vibratory rod	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Estadual Paulista- Faculdade de Filosofia e Ciências	Marcelo Tavella Navega	https://ensaiosclinicos.gov.br/rg/RBR-25ck6t	<NULL>	Older; aged 60-80 years; with osteoporosis diagnosed by bone densitometry examination considering T-Score:equal or less than -2.5 SD; physically active acording to IPAQ which considered moderate and vigorous activities daily and weekly according to 8 answer questions; no pain; no fracture; no severe soft tissue injury in the six months preceding the study; no neurological changes; no cardiovascular changes; no respiratory changes; score upper to 18 points in Mini-Mental State test which considers that guidance notions, immediate memory, attention and calculation, recall and language.	pain, fractures or severe soft tissue injury in the 6 months preceding the study, and neurological, cardiovascular or respiratory diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-4q4kb5	Assessment of bladder location using ultrasound after physiotherapy treatment in women with loss of urine	Recruiting	Intervention	2020-02-03	<NULL>	<NULL>	3445	Bladder Neck Mobility after Physiotherapeutic Intervention in Women with Stress-Urinary Urinary Incontinence: A Randomized Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-16	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4q4kb5	<NULL>	Inclusion criteria for selection of the sample are female, between 40 and 50 years of age, have significant urinary loss through physical exertion, proven by the pad test and have a bladder lowering.	The criteria for exclusion in the study will be pregnancy, urinary tract infections, neurological diseases, total hysterectomy, metal implants, pelvic tumors and clinical and / or surgical treatment for urinary incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-44k3f3x	Assessment of bleaching efficacy using two concentrations of carbamide peroxide in home bleaching in adolescents	Not yet recruiting	Intervention	2024-08-23	<NULL>	<NULL>	7261	Assessment of bleaching efficacy using two concentrations of carbamide peroxide in home bleaching in adolescents: double-blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-44k3f3x	<NULL>	Good general and oral health; 12 to 16 years old; Six upper anterior teeth free of active caries and endodontic treatment; restorations of a maximum of 1/3 of the dental structure; canines (13,23) should be A2 color or darker.	Participants undergoing orthodontic treatment; dental prostheses; severe tooth discoloration (tetracycline stains, fluorosis or devitalized teeth); pregnant and lactating patients, continuous users of anti-inflammatories or analgesics; participants who have already undergone teeth whitening procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-10x4hys8	Assessment of blood levels of triglycerides after eating and their relationship with the risk of suffering heart disease	Recruitment completed	Observational	2023-01-30	<NULL>	<NULL>	5848	Postprandial triglyceride and cardiovascular risk	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Federal Fluminense - Instituto de Saúde de Nova Friburgo	Sociedade União Beneficente Humanitária dos Operários	https://ensaiosclinicos.gov.br/rg/RBR-10x4hys8	<NULL>	Residing in the mountainous region of the state of Rio de Janeiro; Attend the Sociedade Beneficente Humanitaria dos Operarios; Men; Women; Over 18 years	Who do not adhere to the experimental protocol or do not attend one of the planned visits; who use lipid lowering drugs; carriers of genetic disorders that affect lipid metabolism; who are on an energy restricted diet or some macronutrient at the time of the study or in the last two months prior to the study; strict vegetarians, lactovegetarians and ovolactovegetarians; who regularly consume two or more doses of alcoholic beverages 5 grams of alcohol; under 18 years old; mentally disabled	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-2dc9tt5	Assessment of body composition in newborns	Recruiting	Observational	2021-08-10	<NULL>	<NULL>	4822	Assessment of body composition and total body water complemented with the aid of bioelectrical impedance in term and preterm newborns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-07-01	Hospital Universitario Antonio Pedro	Hospital Universitario Antonio Pedro	https://ensaiosclinicos.gov.br/rg/RBR-2dc9tt5	<NULL>	All newborns admitted to the Neonatal Unit of the Hospital Universitário Antônio Pedro.	All seriously ill newborn where manipulation can aggravate their health status; the presence of lesions of discontinuity of the cutaneous integrity at the place where the electrodes are placed; the presence of devices for treatments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-86n2z67	Assessment of brain development in preterm infants who received Maternal Colostrum at birth	Recruiting	Observational	2025-08-05	<NULL>	<NULL>	8184	Assessment of Developmental in preterm infants exposed to Oropharyngeal Colostrum Immunotherapy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-05	Universidade Estadual de Feira de Santana (UEFS/BAHIA)	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-86n2z67	<NULL>	Preterm newborns; with gestational age less than 37 weeks; weight below 1,500 grams; for the exposure group, only those on zero, enteral, or parenteral feeding; and clinically stable in the past three hours	Newborns whose mothers have a diagnosis of psychological disorders; triplet or higher-order multiple pregnancies; newborns with syndromes or congenital malformations; mothers with contraindications to breastfeeding; as well as newborns receiving vasopressor medication at doses higher than 10 mcg·kg⁻¹·min⁻¹ or requiring immediate surgical intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-386svr	Assessment of breathing and exercise capacity of patients with kidney disease that perform breathing exercises	Recruitment completed	Intervention	2014-12-09	<NULL>	<NULL>	359	Functional, physiological assessment and nutritional status of individuals in hemodialysis undergoing respiratory kinesiotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-10	Universidade Federal de Goiás	Viviane Soares	https://ensaiosclinicos.gov.br/rg/RBR-386svr	<NULL>	Patients with renal failure performing hemodialysis for over 3 months; aged between 18 and 70 years; males; with medical clearance to be submitted to inspiratory muscle training; Following the training protocol three times per week	Patients with neurological deficit; chronic lung disease; severe heart disease (unstable angina, previous myocardial infarction, cardiac surgery); infectious disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-4z26f3	Assessment of bucket bath in newborn	Recruitment completed	Intervention	2015-07-30	<NULL>	<NULL>	570	Behavioral effects of the bucket bath in newborn	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Faculdade de Ciências da Saúde do Trairí	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4z26f3	<NULL>	100 Newborn term with 1-3 days of life; both genders; with clinical stability; With informed consent and informed consent signed by the person responsible.	Neonates requiring ventilatory support with infectious processes; open wounds or unhealed; temperature changes; neurological problems; heart failure and seizures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-5wqbzx8	Assessment of cardiac measurements, blood sugar levels and psychological parameters of people with Diabetes Mellitus who practice Physical Exercise	Not yet recruiting	Intervention	2022-11-01	<NULL>	<NULL>	5694	Evaluation of cardiovascular, glycemic and psychophysiological parameters of people with Diabetes Mellitus who practice Physical Exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Instituto Mantenedor de Ensino Superior da Bahia	Centro Universitário de Excelência - UNEX	https://ensaiosclinicos.gov.br/rg/RBR-5wqbzx8	<NULL>	Volunteers with type I or type II diabetes mellitus, female or male; age between 18 to 45 years	Volunteers who have neuropathy developed by diabetes, a history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; suffer some type of muscle injury that prevents the practice of physical exercises; individuals who during the research period fail to show up for physical tests or exercise sessions and who are not available for a new day/time to perform the procedures; who have medical restrictions for the practice of physical exercise or any type of secondary disease that may be aggravated due to participation in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-2jvj92	Assessment of Cardiovascular Risk  and Inflammatory Markers in Patients with Rheumatoid Arthritis	Recruitment completed	Observational	2016-05-05	<NULL>	<NULL>	835	Assessment of Oxidative Stress, Cardiovascular Risk Factors and Metabolic Syndrome Frequency in Rheumatoid Arthritis Patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Estadual de Londrina	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-2jvj92	<NULL>	Patients with rheumatoid arthritis who meet the criteria of the American College of Rheumatology 2010.	Patients with other autoimmune diseases, kidney, heart, liver, diabetes, acute or chronic infectious diseases; use of metformnas and statins, supplements with antioxidant activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-47qws8	Assessment of caries risk and oral health status of infants and children aged 0 to 3 years	Recruitment completed	Observational	2018-07-19	<NULL>	<NULL>	2032	Assessment of caries risk and oral health status of infants and children aged 0 to 3 years	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-04-11	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-47qws8	<NULL>	Volunteers children; both genders, age between 0 and 4 years; weight within the variation limit of 15% of the normal weight considered for children	Voluntary Children over 4 years; who does not want to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-8hzf6ns	Assessment of chewing of complete dentures fixed by one or two implants	Recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7239	Clinical evaluation of masticatory efficiency of mandibular complete dentures converted into Overdentures with one or two implants: randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-03	Centro Universitário do Maranhão - UNICEUMA	Centro Universitário do Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-8hzf6ns	<NULL>	Adult patients; wearing well-adapted upper and lower complete dentures; free from injuries or pathological processes in the oral tissues; with stable health status ASA I or ASA II	Smoking patients; with uncontrolled systemic changes; insufficient rim; wearers of poor quality prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-103k2gpz	Assessment of consumption of processed foods and eating behavior in adults with obesity	Not yet recruiting	Observational	2021-02-12	<NULL>	<NULL>	4544	Assessment of Ultra-processing Food and Eating Behavior in Obesity Adults	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-103k2gpz	<NULL>	Adults; both sexes; age from 18 to 59 years; body mass index (BMI) ≥ 30 kg / m²	Volunteers undergoing clinical and / or drug treatments for weight reduction; use of cortisone and antiepileptic drugs; history of kidney and heart disease; alcohol abuse; smoking; use of vitamin supplementation; diagnosis of obesity due to genetic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-96jkqmh	Assessment of dental sensitivity after in-office bleaching associated or not to desensitizing methods: a randomized clinical trial	Recruitment completed	Intervention	2022-11-28	<NULL>	<NULL>	5749	Assessment of dental sensitivity presence and intensity after dental bleaching associated or not to desensitizing methods	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-15	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-96jkqmh	<NULL>	Age between 18 and 40 years; Good systemic and oral health, with vital anterior teeth and premolars	Underwent any bleaching procedure (in-home or in-office) or any desensitizing protocol within the last 6 months; Teeth with higher value than B1 (Vita Scale; Dentin hypersensitivity history; Dentin hypersensitivity risk factors: enamel cracks or defects, dentin exposure, gingival recession, non carious cervical lesions, acid diet, gastroesophageal reflux and bruxism; Dental plaque, caries or calculus; and periodontal disease; Unsatisfactory dental restoration; Buccal dental restoration in anterior teeth; Severe staining; Using a toothpaste for sensitive teeth within the time of the research; Pregnants or lactating women; Smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-8stsfvp	Assessment of dental stabilizing devices at the dental trauma clinic: a clinical study within the unified health system	Data analysis completed	Observational	2024-08-09	<NULL>	<NULL>	7197	Evaluation of dental splints at the dental trauma clinic: a clinical study in the SUS environment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-30	Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8stsfvp	<NULL>	Patient referred to the Dental Trauma Clinic at the Dental Hospital of the Federal University of Uberlândia; patient with permanent traumatized tooth; both gender;  patient with dental splint; patient aged 6 years and above	Patients with traumatized primary teeth; patients under 6 years old; patients who can not attend follow-ups	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:19
RBR-4bs5xs	Assessment of dentalarch space maintenance after the early extraction of the baby tooth	Recruiting	Intervention	2020-05-26	<NULL>	<NULL>	3877	Assessment of dental arch space maintenance after deciduous molar early loss: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4bs5xs	<NULL>	Age between 6 and 9 years of age; without systemic involvement; both sexes; clinical and radiographic indication of tooth extraction of upper or lower deciduous molar; voluntary; authorization of caregivers.	Presence of craniofacial syndromes or abnormalities; Anodontia of the permanent successor; Early loss of the deciduous canine; Multiple losses in the arch of the tooth to be extracted;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-3qmg5nj	Assessment of distal temperature before and after the use of positive airway pressure in patients with sleep apnea according to preferred times for sleeping and waking up	Not yet recruiting	Intervention	2025-07-22	<NULL>	<NULL>	8149	Assessment of distal temperature before and after the use of Positive Airway Pressure device in patients with Obstructive Sleep Apnea according to chronotype	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-30	Faculdade de Saúde Pública da Universidade de São Paulo	Departamento de Saúde e Sociedade da Faculdade de Saúde Pública da Universidade de São Paulo FSP/USP	https://ensaiosclinicos.gov.br/rg/RBR-3qmg5nj	<NULL>	Patients of both sexes;aged18 years or older; with a diagnosis of moderate or severe obstructive sleep apnea; who are beginning the adaptation process to Positive Airway Pressure (CPAP) with a nasal mask indication, will be recruited	Patients presenting with other sleep disorders as insomnia; parasomnias; narcolepsy; central sleep apnea; uncontrolled clinical disease as diabetes; renal or cardiac failure; recent stroke or coronary insufficiency; recent postoperative period; Chronic obstructive pulmonary disease; oxygen dependence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-6vq3hc4	Assessment of effect of different concentrations of Sodium Hypochlorite on Postoperative Pain and Success Rate of Root Canal Treatment of Necrotic Mandibular Molars	Recruitment completed	Intervention	2022-04-27	<NULL>	<NULL>	6328	Effect of different concentrations of Sodium Hypochlorite on Postoperative Pain and Success Rate of Endodontic Treatment of Necrotic Mandibular Molars	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6vq3hc4	<NULL>	Patients: healthy (ASA I classification); over 18 years of age; asymptomatic; indication for endodontic treatment of manbidular molar (first or second). Dental element: pulp necrosis; negative response to the cold pulp sensitivity test; radiographic image compatible with a radiolucent periapical lesion of origin endodontic.	Patients: who have some type of comorbidity; smokers; pregnant; under 18 years old; who have used medication that may alter the perception pain, such as analgesics or anti-inflammatory, at least 48 hours before the procedure, and use of antibiotics 30 days before treatment. Dental element: prior manipulation of root canals; associated periodontal lesion; interradicular furcation lesion; mobility above grade I; presence of fistula, abscess or edema; calcified or internally resorbed root canals; roots with a degree of curvature greater than 45 degrees; incomplete root formation; C shaped internal anatomical conformation; widely destroyed crown that makes absolute isolation and/or restoration impossible immediate finish with composite resin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-95ddhp	Assessment of eye inflammation after intravitreal injection injection	Recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3249	Randomized, double-blind clinical trial to evaluate inflammation following intravitreal injection	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-95ddhp	<NULL>	Patients with indication for intravitreal anti-VEGF injection followed by vitrectomy to treat complications of diabetic retinopathy.	Glaucoma; previous or current history of uveitis; previous vitreoretinal surgery; patients who have contraindications to the use of anti-VEGF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-5y3rpwk	Assessment of food and nutritional security and the food environment in the homes of students from public schools in Mariana and Ouro Preto - Minas Gerais during and after the Covid-19 pandemic	Recruitment completed	Observational	2023-02-06	<NULL>	<NULL>	5870	Assessment of food and nutritional security and the food environment in the homes of students from municipal schools in Mariana and Ouro Preto - Minas Gerais in the Covid-19 pandemic	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-15	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-5y3rpwk	<NULL>	Minimum age of 18 years; both genders; have an active telephone line; reside in the same household as the student; be responsible for buying/preparing food at the student&apos;s home in the municipal network of Mariana or Ouro Preto-MG	Students from Youth and Adult Education (EJA); permanently busy telephone lines; telephone lines with fax signal; telephone lines with answering machine; inability to speak with the person in charge after 5 attempts on alternate days/times	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-4c9jzv4	Assessment of functional capacity and screening for Sarcopenia in primary care	Recruiting	Observational	2025-10-01	<NULL>	<NULL>	8341	Health in motion: UBS+Active	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Jataí	Secretária Municipal de Saúde de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-4c9jzv4	<NULL>	People who are or are not participating in specific health care programs; present in the waiting room of the primary health care unit; or referred by a physician; minimum age of 18 years; both sexes	Individuals who withdraw from the assessments; present clinical or intellectual limitations that prevent the performance of functional tests; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-9zvtc5b	Assessment of functional capacity, falls, frailty and vulnerability of elderly people	Not yet recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7098	Assessment of functional capacity, falls, frailty and clinical-functional vulnerability of frail and non-frail elderly people	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Ana Paula Felix Arantes	Centro de Referência em Hipertensão e Diabetes	https://ensaiosclinicos.gov.br/rg/RBR-9zvtc5b	<NULL>	Elderly people over the age of 60 years; elderly people which are not included in a regular physical exercise program	Elderly people who might have any clinical conditions that contraindicate the practice of physical activity; elderly people with cognitive deficits that might limit the performance of assessments and/or interventions (present under 19 points on the Mini Mental State Examination)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-83rmpc8	Assessment of functionality in post-COVID patients	Recruiting	Intervention	2022-07-21	<NULL>	<NULL>	5503	Functionality in critical post-COVID patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal de São Paulo	Instituto do Coração -InCor - HCFMUSP	https://ensaiosclinicos.gov.br/rg/RBR-83rmpc8	<NULL>	Patients diagnosed with COVID-19, Need for invasive or non-invasive ventilatory support for more than 24 hours, Planning for ICU discharge.	Neurological or cognitive damage that compromises the execution of the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-4s5nkh	Assessment of gait biomechanics and quality of life of individuals with unilateral lower limb amputation	Recruitment completed	Intervention	2020-05-20	<NULL>	<NULL>	3853	Energy expenditure, gait and Quality of Life assessment of individuals with Transtibial and Transfemoral Amputation undergoing rehabilitation protocol: pre and post prosthesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-06	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4s5nkh	<NULL>	"Individuals with amputations fit for prosthesis;
Amputation levels: unilateral transfemoral and transtibial;Prosthetized individuals who will be protected by the Unified Health System (SUS) of the
of Orthosis and Prosthesis of the Clinical Hospital of the State University of Campinas; Individuals of both sexes;Individuals aged 18 to 60 years;sedentary individuals;Individuals enjoying full intellectual ability"	"Individuals with different amputation levels than those mentioned in the inclusion criteria;
bilateral amputations;Individuals considered unfit for prosthetization;athletes;Individuals with any infection or with absolute medical restriction;intellectually incapable individuals"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-6fb473	Assessment of Gynecological and Dermatological Acceptability of Health Product under Normal Conditions of Use	Recruitment completed	Observational	2019-12-05	<NULL>	<NULL>	3250	Assessment of Gynecological and Dermatological Acceptability of Health Product under Normal Conditions of Use_MKLAB	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-25	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-6fb473	<NULL>	"Women; Age 18 to 65 years old; Phototype I to IV
Whole skin of the region; Occasional user of category products"	"Skin markings in the experimental area that interfere with the evaluation of possible reactions
Pregnant or lactating women;
Participants with a history of allergy to the material used in the study;
History of atopy;
Use of vaginal cream;
Participants with a history of allergy to products of the tested category;
Recent gynecological surgeries;
Discharge;
Carriers of immunodeficiencies;
Kidney, cardiac or liver transplantation;
Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis)
Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Participants included are advised not to change their diet, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-4yk4hg7	Assessment of hand blood circulation during sitting and its relationship with diseases in patients with more than one type of infection	Recruiting	Observational	2022-08-08	<NULL>	<NULL>	5534	Evaluation of the Perfusional Response to Semi-orthostasis and its relationship to organic dysfunctions in patients with Sepsis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-02-09	Lilian Barth Guimarães	Igor Alexandre Cortês de Menezes	https://ensaiosclinicos.gov.br/rg/RBR-4yk4hg7	<NULL>	Individuals aged over 18 years; of both sexes; In group A are septic patients; diagnosed within 24 hours; In Group B are Intensive Care Unit Workers; Group C are critically ill individuals, but not septic	Pregnancy;High risk of death in less than 24 hours; Patients on mechanical ventilation; Severe obstructive arteriopathy; Clinical contraindication to positional mobilization in bed (eg fracture) Patient refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-39mpct	Assessment of health around implants in patients rehabilitated with Removable or Fixed  Prostheses on Implants	Recruiting	Intervention	2016-01-04	<NULL>	<NULL>	669	Peri Implant Health Assessment in patients rehabilitated with Overdentures and Full-arch Fixed Prosthesis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-26	Hospital Universitário Onofre Lopes	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-39mpct	<NULL>	Bimaxillary edentulous; use of double dentures for at least one year; rehabilitation with conventional denture bimaxillary in UFRN; sufficient bone height for implant placement of at least 9,00mm in the mandibular arch.	Diabetes; smoking; osteoporosis; immune deficiency or anticoagulant therapy; patients with neurological diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-7mpnx6t	Assessment of heart health and metabolism in Menopausal women using Isoflavones: a control group study	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7751	Cardiovascular evaluation and metabolic profile of women in Menopause using Daidzein and Genistein: a placebo-controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-03	Fundacao Universidade de Pernambuco	Fundacao Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7mpnx6t	<NULL>	60 female volunteers; age between 49 and 52 years old; in menopause after one year of the last menstrual period	Patients with cardiorespiratory disorders; neurological; and other known impairments that prevent the subject from carrying out the procedures; do not drink alcoholic beverages; nor consume substances containing isoflavones such as green tea, peas, peanuts, chickpeas, lima beans, broad beans, lentils and flaxseeds; or carry out high-intensity training for 24 hours prior to the assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-7y24t7t	Assessment of heart rate variability and body composition in the elderly undergoing Exercise and Gametherapy	Not yet recruiting	Intervention	2022-08-11	<NULL>	<NULL>	5593	Evaluation of autonomic cardiac modulation and body composition in elderly submitted to the Protocol of exercise and the Gametherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Sáskia Fürstenberg Thoma	Unifacisa- Centro Universitário	https://ensaiosclinicos.gov.br/rg/RBR-7y24t7t	<NULL>	Active elderly people who do physical activity according to the IPAQ (short form) will be included, a questionnaire that aims to carry out a global survey of the prevalence of physical activity in the world (MATSUDO et al, 2001) (ANNEX B). They must be elderly people over 60 years of age who live in the city of Campina Grande-PB and/or adjacent cities, due to the ease of accessibility to the services offered; that have means of transportation that allow their transport to the collection site, as this is an elderly sample group, those who are unable to move will be under the responsibility of the researcher to transport them; those elderly with chronic degenerative diseases may also be included, if they are under drug control.	Exclusion criteria will be those who present disabling pathologies for performing aerobic activities (cardiopathies and decompensated respiratory pathologies), they will be excluded because the protocol requires a satisfactory level of cardiorespiratory resistance to perform the activities proposed by the protocol; those elderly who have musculoskeletal disorders that prevent them from participating in the collection and/or who make use of gait devices since the exercises require large amplitude movements, those who are over 80 years old also do not participate, thinking they have a risk that overcome the benefit and elderly people who are performing other aerobic or anaerobic activities so as not to interfere with the evidence of the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-72tgny	Assessment of immediate and prolonged skin irritation and / or allergy.	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2724	Assessment of Primary Dermal Irritability, Dermal Irritability and Dermal Sensitization (HRIPT).	<NULL>	1-2, single-arm-study, single-blind	1-2	<NULL>	<NULL>	<NULL>	2019-04-16	Medcin Instituto da Pele Ltda.	Medcin Instituto da Pele Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-72tgny	<NULL>	Age between 18 and 70 years; Phototypes I, II, III and IV as adapted Fitzpatrick scale Annex 1; Skin of the whole test region;	"Gestation or risk of gestation and / or lactation when women; Use of anti-inflammatory drugs 30 days and / or immunosuppressants for up to three months prior to selection; Immunosuppression by drugs or active diseases;
Decompensated endocrinopathies; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days prior to evaluation or during the study period; Forecast of sea baths, swimming pool or sauna during the study; Practice water sports during the study; Dermographism; Use of oral or topical treatment with vitamin A acid and / or its derivatives up to 1 month before the start of the study; Aesthetic and / or dermatological treatment in the body within 03 weeks prior to selection; Scheduled vaccination during the study period or until 03 weeks prior to screening; History of sensitization and irritation to topical product; Active skin conditions (local and / or disseminated) that may interfere with the results of the study; Use of new drugs and / or cosmetics during the study; Skin reactivity; Previous participation in studies with the same product; Congenital or acquired immunodeficiency; Relevant clinical history or current evidence of alcohol or other drug abuse; Known or suspected intolerance of any ingredient in the study products test or comparative products; History of lack of adherence or unwillingness to adhere to the study protocol; Employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study. Other conditions considered by the researcher as reasonable for disqualification of study participation. If Yes, it should be described in observation in the clinical file;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-22qrch	Assessment of irritability and sensitization of health products through (patch test)	Not yet recruiting	Observational	2019-11-01	<NULL>	<NULL>	3162	Assessment of thermal irritability, accumulation and sensitization of health products by patch test _ mklab	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-25	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-22qrch	<NULL>	"Healthy skin in the study region; Age 18 to 65 years; Gender: male and female; Participants with phototypes I, II, III and IV (according to the Fitzpatrick classification); No history of irritation / allergy to the material used in the study; Having signed the Informed Consent Form (ICF);
Participants wishing to participate in the study without financial gain. They will be reimbursed for test-related expenses such as transportation and food"	"Participants who refuse to participate in the study in question.
Skin tags in the experimental area that interfere with the evaluation of possible skin reactions;
Active dermatoses (local and widespread) that may interfere with the study results;
Pregnant or lactating women;
History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines;
Volunteers with a history of allergy to the material used in the study;
History of atopy;
History of conditions aggravated or triggered by ultraviolet radiation;
Carriers of immunodeficiencies;
Kidney, cardiac or liver transplantation;
Prediction of intense sun exposure or tanning session during the study period;
Prediction of bathing in the sea, pool or sauna during the study;
Participants who practice water sports;
Use of the following systemic topical drugs: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection;
Treatment with acidic vitamin A and / or its derivatives orally or topically within 1 month before the start of the study;
Expected vaccination during the study or up to 03 weeks before the study;
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Included participants are advised not to change diet, cosmetic and hygiene habits, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8kqhkz7	Assessment of Lavandula angustifolia Essential Oil in Temporomandibular Disorder: A Clinical Trial Investigating Therapeutic Effects	Recruiting	Intervention	2025-07-29	<NULL>	<NULL>	8162	Evaluation of the effect of Lavandula angustifolia Essential Oil as a treatment for Temporomandibular Disorder: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-05	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8kqhkz7	<NULL>	Both genders; alphabetized individuals; aged between nineteen and forty five; diagnosis of myalgia or myofascial pain with spread or reference; score of at least six on the subjective pain scale	Individuals with cognitive impairments that prevent them from answering the questionnaires; pregnant women; nursing mothers; people who are using analgesics within the 48 hours prior to the first assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-83mprnv	Assessment of left ventricular function using imaging exam	Not yet recruiting	Observational	2021-11-29	<NULL>	<NULL>	5060	Assessment of left ventricular function using Myocardial Strain in cardiac surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-15	Universidade do Extremo Sul Catarinense	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-83mprnv	<NULL>	Patients undergoing cardiac surgery with extracorporeal circulation (ECC) and left ventricular ejection fraction (LVEF) ≥ 50% who will undergo echocardiographic monitoring with myocardial strain.	Patients undergoing cardiac surgery without CPB, patients with LVEF &lt; 50%, urgent and emergency surgery, patients with grade II or III diastolic dysfunction, use of intra-aortic balloon pump in the preoperative period and refusal to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-6cs352	Assessment of life habits and health status associated with Fatigue	Recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1440	Fatigue Management Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-09	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-6cs352	<NULL>	men; adults; alternating shift workers; Vitamin D levels less than 30 ng/mL or less than 75 nmol/L; blood glucose increased; lipid profile increased; blood pressure increased; waist circumference increased	clinical history of malabsorption syndrome, kidney disease, liver or thyroid changes; use of anticonvulsant drugs, steroids, hormones or supplements of vitamins and minerals; altered levels of creatinine, calcium and albumin depending on the kit to be used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-7gfj5r	Assessment of life habits and health status associated with Fatigue	Recruiting	Intervention	2019-11-06	<NULL>	<NULL>	3170	Fatigue Prevention and Management in Mine Workers	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Ouro Preto	Vale S A	https://ensaiosclinicos.gov.br/rg/RBR-7gfj5r	<NULL>	Workers shortlisted for the high performance operator program according to the company&apos;s operational technical criteria will be included in the study	"Operators who submit will be excluded:
Evidence of substance abuse or dependence in the last 5 years.
Non-medical psychiatric treatment at least 4 weeks before study.
Clinically significant 24-hour Holter abnormality as complex ventricular arrhythmias, defined as sustained ventricular tachycardia, second-degree mobitz type II or more atrioventricular block, sinus pauses longer than 3 seconds, presence of more than 30 episodes of extrasystoles per hour, and atrial fibrillation or flutter
Decompensated metabolic disorders such as diabetes with glycated hemoglobin (HbA1c) greater than 9% and dyslipidemia with LDL greater than 180 mg / dL or triglycerides greater than 500 mg / dL.
Degenerative chronic diseases (autoimmune, neoplasia, immunodeficient disease and neurological diseases).
Operators with signs and symptoms of infectious diseases.
Gastrointestinal disorders with altered absorption.
Carriers of moderate to severe sleep disorder
Using the following medicines: amitriptyline, clomipramine, imipramine, nortriptyline, fluoxetine, sertraline, paroxetine, venlafaxine, citalopram, lithium carbonate, valproic acid, sodium divalproate, carbamazepine, risperidone, olanzapine, haloperidol, monoaminoxpride inhibitors, moclobemide or selegiline."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-34tv3fz	Assessment of Locked Nose Improvement in patients who received a Nasal Implant	Data analysis completed	Observational	2021-12-06	<NULL>	<NULL>	5076	"Evaluation of the improvement rate of Nasal Obstruction by the NOSE Scale in patients
submitted to Poly(ε-caprolactone) Absorbable Nasal Implant (PCL)"	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-34tv3fz	<NULL>	Patients aged between 50 and 79 years; with insufficiency of the nasal lateral wall confirmed through the positive Modified Cottle maneuver; with severe or extreme nasal obstruction in the evaluation by the NOSE Scale (Nasal Obstruction Symptom Evaluation Scale) (score ≥ 55); impossibility or refusal to perform functional rhinoplasty; and lack of significant improvement after clinical treatment for at least four continuous months.	Smoking patients; with decompensated chronic rhinitis; with nasosinusal polyposis; with nasal granulomatous diseases; with any inflammatory or infectious diseases or conditions in the nasal or facial region; with a history of nasal implants or some type of nasal filling; with immunosuppressive disease; with healing disorders; with uncontrolled systemic diseases such as diabetes or heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-3x8xc3	Assessment of Mastication and Quality of Life in Frail Elderly Persons	Recruitment completed	Observational	2018-01-11	<NULL>	<NULL>	1563	Masticatory Function and Quality of Life in Frail Elderly Persons	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-13	Faculdade de Odontologia de Piracicaba - UNICAMP	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-3x8xc3	<NULL>	Completely edentulous; wearing bimaxillary dentures; presence of the frailty phenotype (experimental group); abscence of cognitive problems and / or dementia; abscence of neurodegenerative diseases such as Parkinson&apos;s and Alzheimer&apos;s.	History of stroke; signs and symptoms of temporomandibular disorders; cognitive deficit; uncontrolled systemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-10xjp5tz	Assessment of maxillary bones through imaging tests after treatment with a device to increase the width of the maxilla compared to surgical treatment in adults.	Recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5205	Three-dimensional evaluation of biological effects on the craniofacial complex of surgically assisted rapid maxillary expansion (SARME) and mini-implants (MARPE) in adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Faculdade de Odontologia Universidade de São Paulo	Hospital Universitário da da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10xjp5tz	<NULL>	Brazilian nationality; Craniofacial growth completed; Transverse maxillary deficiency, with or without posterior crossbite, unilateral or bilateral; Age between 25 and 45 years old, male and female; permanent dentition, with at least the first or second permanent upper molars; Good dental conditions and periodontal health. No history of previous orthodontic treatment; Absence of systemic diseases or congenital deformities. Transverse maxillary discrepancy greater than 4mm and less than 10mm	Absence of permanent maxillary first molars and pre- molars. Presence of deformities or congenital syndromes; Presence of cleft lip and palate; Presence of systemic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-7jd2mm	Assessment of measures to improve sleep and quality of life of patients with heart failure	Recruitment completed	Intervention	2014-07-09	<NULL>	<NULL>	310	Efficacy of sleep hygiene and phototherapy in sleep and quality of life measures of patients with heart failure - a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-30	Escola de Enfermagem da Universidade de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-7jd2mm	<NULL>	Heart failure functional class I, II or III; have an active telephone contact; Do no pharmacological / non-pharmacological treatment for sleep improvement.	Cognitive impairment; total score in the Pittsburg Sleep Quality Index (PSQI) &lt; or equal to 5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-10jcg95y	Assessment of metabolic changes as predictors and follow-up effectiveness Pre-surgical Speech Therapy in the prevention of Swallowing and Voice Changes after Anterior Cervical Spine Surgery	Recruitment completed	Intervention	2023-05-12	<NULL>	<NULL>	6071	Assessment of predictive metabolic factors and Speech Therapy Pre-surgical Protocol efficacy in the prevention of Dysphagia and Dysphonia after Anterior Cervical Arthrodesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	https://ensaiosclinicos.gov.br/rg/RBR-10jcg95y	<NULL>	All patients with indication for performing anterior cervical arthrodesis during the period of study	Review performance surgery or previous surgery in the cervical region; previous neurological diseases; diagnosis of previous gastroesophageal reflux; previous dysphagia and dysphonia; evolution to framework tetraparesis or tetraplegia after the surgical procedure; postoperative tracheostomy; failure due to implant breakage or loosening of screws and/or intersomatic devices; not available for video call	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-2y6fv92	Assessment of muscle electrical activity during Cardiopulmonary Testing	Recruitment completed	Observational	2022-12-30	<NULL>	<NULL>	5792	Electromyographic evaluation during Cardiopulmonary Exercise Test: retrospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-01	Centro Universitário da Paraíba (UNIESP)	Centro Universitário da Paraíba (UNIESP)	https://ensaiosclinicos.gov.br/rg/RBR-2y6fv92	<NULL>	The inclusion criteria for the research will be obese subjects with any of the three different degrees of obesity (body mass index-BMI above 30kg/m2); normal weight individuals and individuals with a previous clinical diagnosis of lung disease (obstructive pulmonary disease and/or restrictive disease) of both genders; aged 18 years or over; active or sedentary; with no change in the locomotor system and/or change in balance detected in an initial examination carried out in a routine evaluation from June to December 2021 at the Clinic Clinic	Subjects who may have had their data analyzed/evaluated in a database and incorrectly tabulated in an Excel spreadsheet; who have gaps in the tabulation of anthropometric variables and/or cardiopulmonary exercise test (CPET) and electromyography (EMG) variables; who had a test of cardiopulmonary effort with less than the recommended time for data evaluation (time less than 8 minutes) or those with signal failure of the EMG tracing during the test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-9s8yt9	Assessment of muscle stress in patients with moderate to severe COPD	Recruitment completed	Intervention	2019-10-02	<NULL>	<NULL>	3021	Assessment of muscle stress in patients with moderate to severe COPD	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-16	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-9s8yt9	<NULL>	Inclusion criteria were sedentary patients with moderate to severe COPD diagnosed according to the GOLD criteria, who did not engage in any clinically stable physical activity.	We excluded oxygen-dependent patients with a locomotor or neurological disorder and clinical instability, such as an indication of changes in treatment regimen or exacerbation of any severity in the previous 12 weeks and concomitant diagnosis of malignant diseases, chronic heart failure, liver disease or neuropathy, or actively engaged in any physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-9n2854x	Assessment of nails, skin and hair in menopausal women after use of oral collagen or placebo	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7184	Evaluation of nail physiology, dermal thickness and hair shaft thickness in postmenopausal women supplemented with hydrolyzed oral collagen: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9n2854x	<NULL>	Menopausal women; aged 55 to 70; living in the region of Botucatu; agreeing to participate in the study	Immunocompromised women or those using immunosuppressive drugs; diabetics; using anticoagulants or with coagulation disorders; using oral retinoids;  patients with kidney disease;  thyropathies and inflammatory and infectious diseases of the fingernails and current and previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risk; interferes with the safety or efficacy of the proposed treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-283y5bp	Assessment of non ablative Radiofrequency in menopausal women with genitals and urinary syntoms	Recruiting	Intervention	2026-03-16	<NULL>	<NULL>	8982	Assessment of non ablative Radiofrenquency in peri menopausal and posmenopausal women with Genitourinary Syndrome	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Fundação José Bonifácio Lafayette de Andrada	<NULL>	<NULL>	<NULL>	Menopausal women (aged 50-70 years); dryness; dyspareunia; mild urinary incontinence.	Active vaginal infections;chronic vaginal infections;recent use of vaginal regenerative therapies; patients with contraindications to energy use;active cancer; active tuberculosis;pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-5ky63kv	Assessment of oral acceptability after use of a mouth spray and participants impressions after use, following the instructions for use	Recruitment completed	Intervention	2025-09-24	<NULL>	<NULL>	8309	Assessment of oral cavity acceptability after use of a mouth spray (class I health product) and assessment of efficacy perceived by the research participant, under recommended conditions of use (E007843A)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	ALS Beauty &amp; Personal Care Ltda	ALS Beauty &amp; Personal Care Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5ky63kv	<NULL>	Healthy research participants; agreement to adhere to the study procedures and requirements and to attend the institute on the days and times determined for the evaluations; ability to consent to their participation in the study; age from 18 to 70 years; any sex; vaccinated against covid 19; who self declare as having a predisposition to sensitive oral mucosa and with the occurrence of mouth ulcers or oral wounds caused by factors such as stress, acidic foods, burns, ingestion of hot foods, use of orthodontic appliances, stomatitis, use of medications or herpes; who self declare as having sensations of dry mouth	Participants who smoke; are pregnant or breastfeeding; have changes outside the normal range assessed by the dentist in the oral cavity that may compromise the results of the study or that may put the participant&apos;s health at risk; are undergoing any medical treatment that, in the opinion of the investigator, may compromise the results of the study or put the participant&apos;s health at risk; have skin conditions in the area where the product is applied; have removable partial or total dentures, provided that more than 50% of the teeth are missing; have type 1 diabetes mellitus; are insulin-dependent diabetes; have complications resulting from diabetes, such as retinopathies, nephropathy, neuropathy; have dermatoses related to diabetes, such as plantar ulcers, lipoid necrobiosis, granuloma annulare, and opportunistic infections; have a history of episodes of hypoglycemia, diabetic ketoacidosis, and/or hyperosmolar coma; are undergoing immunosuppression; are currently using topical or systemic corticosteroids, immunosuppressants, and antihistamines; have a history of reactions to the category of the product being tested; other diseases or medications that may directly interfere with the study or put the health of the research participant at risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-6nzzhqk	Assessment of oxidative stress, damage to the membrane lining the cells of blood vessels, phase angle and clinical evolution in Heart Infarction	Data analysis completed	Observational	2025-04-15	<NULL>	<NULL>	7923	Evaluation of oxidative stress, endothelial glycocalyx injury, phase angle and clinical outcome in Acute Myocardial Infarction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-24	Unidade de Emergência do Hospital das Clínicas de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)	https://ensaiosclinicos.gov.br/rg/RBR-6nzzhqk	<NULL>	Patients diagnosed with acute myocardial infarction with ST segment elevation; male and female; of different races; aged 18 years or older within 72 hours of hospital admission	Patients with diagnosis of renal or hepatic disease; cancer; age over 80 years; use of external orthopedic or cardiac devices; mechanical ventilation; pregnancy; cardiorespiratory arrest or cardiogenic shock at admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-377483	Assessment of pain after adjustment occlusal in root canal treatment	Not yet recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1152	Assessment of postoperative pain after adjustment occlusal in endodontic treatment: a randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-17	Universidade Federal do Amazonas (UFAM)	Universidade Federal do Amazonas (UFAM)	https://ensaiosclinicos.gov.br/rg/RBR-377483	<NULL>	Healthy patients of both sexes (male and female) aged between 18 and 60  who have root canal treatment indication in molars permanent, diagnosed with irreversible pulpitis; presence of occlusal contact prior to endodontic treatment; presence of natural or artificial opposing tooth in the occlusal contact in treated endodontically teeth; to have phone number to contact.	Pregnant women, patients aged less than 18 and greater than 60 years, patients taking some anti-inflammatory medication or antibiotic treatment at the time, immunocompromised, with hypersensitivity to nonsteroidal anti-inflammatory; previous diagnosis of bruxism or clenching; absence of natural or artificial tooth opposite to the tooth to be treated endodontically; complications endodontic type: calcifications, external or internal resorption, partial formation of the apical apex with dental drilling, with longitudinal or vertical fractures and severe periodontal disease; treatments in multiple sessions; patients without phone contact.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-373nm7	Assessment of pain and side effects between industrialized ointment with Lidocaine and manipulated Lidocaine ointment with Tetracaine for Hair Removal with Laser LightSheer®	Recruitment completed	Intervention	2020-09-22	<NULL>	<NULL>	4273	Antalgic and adverse effects of the industrialized topical formulation of Lidocaine 4 compared to the manipulated formulation of Lidocaine 23 associated with Tetracaine 7 in patients referred for Laser Hair Removal Lightsheer®	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-05-11	Clínica Dermatológica Dra Luciena Ortigosa	Clínica Dermatológica Dra Luciena Ortigosa	https://ensaiosclinicos.gov.br/rg/RBR-373nm7	<NULL>	Patients with a desire for epilation; Patients with pigmented hair in axilla, face, legs or groin; Both sexes; Age between 12 and 90 years	Patients with a history of allergic reaction to lidocaine or tetracaine; Patients with keloid; Sun exposure in the four weeks prior to the laser procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-10vtd55m	Assessment of pain caused by respiratory therapy in children after heart surgery	Data analysis completed	Intervention	2022-12-29	<NULL>	<NULL>	5786	Assessment of pain caused by respiratory therapy in children with congenital heart disease after surgery	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-01-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10vtd55m	<NULL>	Children with congenital heart disease; both genders; age between 0 and 18 years; undergoing heart surgery	Parental request; intraoperative death; hemodynamic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-8rczn6p	Assessment of pain, ease of insertion and clinical performance of three types of intrauterine devices (copper, Mirena® and Kyleena®) in adolescents	Not yet recruiting	Intervention	2021-10-15	<NULL>	<NULL>	4991	Assessment of pain, ease of insertion and clinical performance of three types of intrauterine devices (copper, Mirena® and Kyleena®) in adolescents: partially blind randomized study	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-11-10	Universidade Estadual de Campinas	Universidade de Gurupi- UNIRG	https://ensaiosclinicos.gov.br/rg/RBR-8rczn6p	<NULL>	Women up to 19 years old who want contraception with an IUD, nuligest or with children.	Confirmed or suspected pregnancy. Sexually Transmitted Disease (STD) active. Pelvic inflammatory disease.  Malformation of the uterus or intracavitary myoma that distorts the uterine cavity.Genital bleeding of an unknown nature. Previous surgery in the cervix.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-6pzvnt8	Assessment of pain, quality of life and success of root canal treatment after different cleaning methods: randomized clinical trial	Recruiting	Intervention	2025-01-15	<NULL>	<NULL>	7664	Assessment of postoperative pain, quality of life and success of endodontic treatment after different irrigant activation protocols: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-11	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pzvnt8	<NULL>	Participants will be selected at the Faculty of Dentistry of the University of São Paulo (FOUSP); individuals classified by the American Society of Anesthesiology as ASA I and II; aged between 18 and 60 years old; both genders; single-rooted teeth with single canal; diagnosis of pulp necrosis; evidence of symptomatic or asymptomatic apical periodontitis; radiolucency with a minimum diameter of 2 x 2 mm based on the initial periapical radiograph	Individuals classified by the American Society of Anesthesiology as ASA III or higher; pregnancy; allergies to local anesthetics, sodium hypochlorite, latex, or Ibuprofen; tooth with probing depth greater than 3mm; mobility score grade 2 or higher; subgingival fracture or caries that makes absolute isolation difficult or is not capable of definitive restoration; root fracture; any type of root resorption; incompletely formed root apex; endodontic treatment performed; individuals who took analgesic or anti-inflammatory medication that could alter pain perception within at least 12 hours before the start of the treatment session or those who took antibiotic medication 2 weeks before the start of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-1094zfg5	Assessment of patient satisfaction with different types of periodontal probes	Not yet recruiting	Intervention	2024-10-24	<NULL>	<NULL>	7456	Assessment of patient satisfaction with periodontal probes: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-1094zfg5	<NULL>	Age between 18 and 60 years; absence of gingival inflammation or periodontal disease; consent to participate in the research; both genders	Self-reported systemic disease; smokers, pregnant women and those with dentin hypersensitivity; patient using non-steroidal anti-inflammatory drugs and analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-8rgqzxf	Assessment of patients undergoing Echocardiography	Recruiting	Observational	2024-01-02	<NULL>	<NULL>	6699	Cohort of patients undergoing an Echocardiographic study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-01-01	Irmandade Santa Casa de Misericórdia de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8rgqzxf	<NULL>	18 years or older. Underwent echocardiography at Santa Casa de Misericórdia de Porto Alegre. Both genders	No echocardiographic report available	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-9k5tc4d	Assessment of pH stability and influence on tooth sensitivity after in-office dental whitening in adult patients: a double-blind randomized clinical trial	Not yet recruiting	Intervention	2023-12-21	<NULL>	<NULL>	6675	Influence and stability of pH on the sensitivity of in-office teeth whitening in adults: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-05	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9k5tc4d	<NULL>	Participants over 18 years old; both genders; with good general and oral health conditions; caries-free upper teeth and upper anterior teeth free of restorations on the buccal surface; they should also have  A2 or darker colored central incisors, evaluated against a tooth value-driven visual color scale  (Vita Classical, Vita BleachedGuide)	Pregnant women; nursing mothers; smokers; users of fixed orthodontic appliances; with pre-existing anterior restorations; presence of severe intrinsic stains (stains due to tetracycline use, fluorosis and pulpless teeth); participants with a previous history of tooth sensitivity or any associated pathology (bruxism , gingival recession, non-carious lesion with exposed dentin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5syg5gk	Assessment of possible effects of manual therapy on the nervous system	Recruiting	Intervention	2022-09-01	<NULL>	<NULL>	5588	Neurophysiological assessment of motor responses determined by fascial manipulation: a randomized, crossover, double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal do ABC	Universidade Federal do ABC	https://ensaiosclinicos.gov.br/rg/RBR-5syg5gk	<NULL>	Healthy male and female volunteers aged between 18 and 50 years who agree to sign the informed consent form and who meet the criteria listed below will be included. Do not make regular use of psychoactive substances and or with diagnosed psychopathies; They do not have body deformities, stiffness, degenerative changes, osteoarthritis, rheumatoid arthritis and/or related pathologies; Have no history of orthopedic surgery on the trunk or axial segments of the limbs; Do not have contraindications for the use of Transcranial Magnetic Stimulation such as the presence of metals in the skull or implanted devices, history of epilepsy, pregnancy, use of drugs that may interfere with cortical electrical activity such as anticonvulsants, antidepressants and antipsychotics and complications with exposure to magnetic fields ; They do not have metallic implants in the skull, metallic wires implanted in the stimulation region, cochlear implants and pacemakers; They are not incapable of understanding the content of the assessment tools used; Do not present any other situation that the researchers consider as a limiting factor for the study	Volunteers who present any discomfort, psychological or physical, will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-99qvrnj	Assessment of postoperative events after Ozonetherapy in lower third molar Extractions	Not yet recruiting	Intervention	2024-08-19	<NULL>	<NULL>	7231	Effects of Ozonetherapy in the postoperative period of lower third molar Extraction – pilot, randomized, blind, split-mouth clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-20	Instituto de Ciência e Tecnologia - Campus de São José dos Campos – Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Campus de São José dos Campos – Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-99qvrnj	<NULL>	Female and male patients,  need of third molar extraction; regardless of gender; patients who have not used analgesics or anti-inflammatories in the last 15 days; have teeth in opposing semi-included or included hemi-arches, meeting the same classification as Pell &amp; Gregory (1933); aged between 18 and 30 years; who agree to participate in the research voluntarily, being aware of the risks and benefits, and sign the Free and Informed Consent Form (TCLE).	Patients who present local or systemic changes that contraindicate the procedure; patients undergoing drug treatments that interfere with the methodology; erupted lower third molars; patients allergic to anesthetics and medications; patients with contraindications to the use of ozone therapy; smoking patients; pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-5mst34n	Assessment of postural balance of the elderly by Baropodometry	Recruitment completed	Observational	2021-05-28	<NULL>	<NULL>	4689	Assessment of postural balance of the elderly by Baropodometry	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Universidade Federal do Triângulo Mineiro	Comitê de ética e pesquisa da Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5mst34n	<NULL>	Have age greater than or equal to 60 years; ambulate without assistive devices; not have neurological disease and/or musculoskeletal that compromises the ambulation; meet the International Physical Activity Questionnaire (IPAQ) adapted to determine which group will be part; sign the Informed Consent Form	Non attendance in the assessments; withdrawal during any time of the study, the occurrence of risk of falling when performing some of the ratings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-86kcy37	Assessment of praziquantel medication for children living in areas where schistosomiasis is common in Bahia and Sergipe	Recruiting	Intervention	2024-06-14	<NULL>	<NULL>	7068	Evaluation of the efficacy and safety of pediatric praziquantel in children residing in endemic areas of Bahia and Sergipe	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2024-12-09	Centro de Pesquisas Gonçalo Moniz - Fundação Oswaldo Cruz - BA	Instituto Gonçalo Moniz (IGM) - Fundação Oswaldo Cruz (Fiocruz-BA)	https://ensaiosclinicos.gov.br/rg/RBR-86kcy37	<NULL>	Age between 3 months and 6 years; both sexes; presence of at least one *Schistosoma mansoni* egg detected by the parasitological methods used; minimum body weight of 8 kg for children aged 2 to 6 years and 5 kg for children under 2 years of age	Presence of conditions that contraindicate the use of praziquantel at the physician’s discretion, such as viral or bacterial infections, diarrhea, gastroenteritis, among others; prior treatment with praziquantel within the past 6 months; concomitant treatment with other drugs that may affect praziquantel metabolism, such as certain antiepileptics, glucocorticoids, chloroquine, rifampicin, or cimetidine; participants with hepatosplenic schistosomiasis; participants with body temperature above 37.5 °C; for infants and breastfeeding children, maternal treatment with praziquantel within the 3 days preceding the administration of pediatric praziquantel	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:03
RBR-9jknqq	Assessment of preventive use of non steroidal antiinflammatory on increased pain sensibility  after third molar extraction	Data analysis completed	Intervention	2015-06-29	<NULL>	<NULL>	534	Assessment of preemptive use of non steroidal antiinflammatory on hyperalgesia after third molar extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-13	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9jknqq	<NULL>	Patients older than 18 years who agree to participate in research, with good general health,  without any medicine intake in the last 15 days (except contraceptives),  patients who have indicated bilateral extraction of impacted lower third molar, in similar conditions on both sides.	Patients who do not want to participate in the study, patients who have used any drug in the last 15 days (except contraceptives), pregnancy, breastfeeding, and presence of pericoronitis related to lower third molar, patients who report history of allergies or adverse drug effects used in the study, actual or past history of ulcer disease or gastrointestinal bleeding, renal failure, advanced liver disease and coagulopathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-8w8rxbb	Assessment of Primary and Accumulated Dermal Irritability and Sensitivity of a cosmetic product	Not yet recruiting	Intervention	2024-12-21	<NULL>	<NULL>	7622	Assessment of Primary, Accumulated Dermal Irritability and Sensitization of a facial moisturizer, through patch testing (Patch Test)	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-21	IPCLIN - Instituto de Pesquisa Clínica Integrada Ltda	IPCLIN - Instituto de Pesquisa Clínica Integrada Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8w8rxbb	<NULL>	Full skin on the back;age from 18 to 59 years old;male and female;participants with phototypes I, II, III and IV according to the Fitzpatrick classification;absence of history of irritation and allergy to the material used in the study;have signed the free and informed consent form;participants who wish to participate in the study without financial profit	Participants who refuse to participate in the study in question;skin marks in the experimental area that interfere with the assessment of possible skin reactions,such as scars,increased hairiness,large quantities of ephelides and nevus and sunburn;active dermatoses that could interfere with the study results;pregnant or breastfeeding women;history of allergic reactions,irritation or intense sensations of discomfort to topical products such as cosmetics and medicines;volunteers with a history of allergy to the material used in the study;history of atopy;history of pathologies aggravated or triggered by ultraviolet radiation;intense sun exposure or tanning session up to 15 days before the initial assessment;expected intense sun exposure or tanning session during the study period;plan to take a swim in the sea, swimming pool or sauna during the study;participants who practice water sports;use of the following systemic topical medications:immunosuppressants,antihistamines,non-steroidal anti-inflammatory drugs,and corticosteroids up to two weeks before the selection;treatment with acid vitamin A and/or its derivatives orally or topically up to 1 month before the start of the study;anticipation of vaccination during the study or up to 3 weeks before the study,so as not to correlate the possible side effects of the vaccine with the study in question;any condition not mentioned above that,in the opinion of the investigator,may compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-74b44vf	Assessment of Primary and Accumulated Irritation Potential, Skin Sensitization Potential and Skin Allergy and Toxicity Potential by Ultraviolet Light Accompanied by a Dermatologist for the Gel Cream Product	Recruitment completed	Observational	2023-07-05	<NULL>	<NULL>	6209	Assessment of Primary and Accumulated Irritation Potential, Skin Sensitization Potential and Skin Photoallergy and Phototoxicity Potential Supervised by Dermatologist for the Cream-Gel Product	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-25	Kosmosciense Ciência e Tecnologia Cosm Imp Exp Ltda	Kosmosciense Ciência e Tecnologia Cosm Imp Exp Ltda	https://ensaiosclinicos.gov.br/rg/RBR-74b44vf	<NULL>	Healthy research participant. Age range between 18 and 70 years. Gender: female and male. Phototype (Fitzpatrick): I to IV. Agree to adhere to the requirements of the study in combating the COVID-19 pandemic, through preventive measures: use a mask according to WHO guidelines, use the mask when traveling to the research center and during the study procedures, maintain the social distancing; wash your hands frequently with soap and/or alcohol gel and attend the research center only at scheduled times to avoid crowds. Agreement not to wet the site during the entire test period. Understand the test procedures and agree to adhere to the study requirements. Absence of inflammatory dermatosis or tattooing at the application site. Signature of the Free and Informed Consent Term (TCLE)	Pregnancy, lactation. Participant who belongs to the risk group for COVID-19, that is, with chronic cardiovascular, kidney and respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group. Use of corticosteroids, antihistamines and/or anti-inflammatories. History of allergy to cosmetic products and/or health products. Presence of localized or generalized dermatological diseases. Presence of active inflammatory dermatoses in the test region. Presence of nevic lesions in the test region. Personal or family history of skin cancer. Use of topical or systemic photosensitizing medication. History of phototoxic or photoallergic reactions. Photo-induced pathologies, such as Lupus Erythematosus, Recurrent Herpes Simplex, History of dermatoses caused by light, such as solar urticaria and polymorphous light eruption. Frequent exposure to the sun or tanning beds. Have participated in an allergenicity study within a period of less than four weeks from the beginning of the study. Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevi in large numbers, sunburn). Active dermatoses (local or disseminated) that may interfere with the study results. History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics, health products or medicines. Research participants with a history of allergy to the material used in the study. Background of atopy. History of pathologies aggravated or triggered by ultraviolet radiation. Immunodeficiency patients. Intense sun exposure or tanning session up to 15 days before the initial assessment. Prediction of intense sun exposure or tanning session during the study period. Provision of bathing in the sea, swimming pool or sauna during the study. Research participants who practice water sports. Dermographism. Use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to 2 weeks before selection. Treatment with acidic vitamin A and/or its derivatives orally or topically up to 01 month before the start of the study. Body aesthetic and/or dermatological treatment up to 03 weeks before selection. Prediction of vaccination during the study or up to 03 weeks before the study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. History of non-compliance or unwillingness to adhere to the study protocol. Professionals directly involved in carrying out this protocol and their families. Be participating in some other study at the time. Any condition that, in the opinion of the researcher, could compromise the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-8n2y6sq	Assessment of proctological, gynecological and dermatological acceptability using the product at home	Not yet recruiting	Intervention	2023-02-22	<NULL>	<NULL>	5916	Evaluation of the proctological , gynecological and dermatological acceptability of a health product under normal conditions of use_MAKE03.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-20	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Makelife Comercio Atacadista e Varejista LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8n2y6sq	<NULL>	Gender: female; Age: 18 to 59 years; Phototype: I to IV; Intact skin in the region; Occasional user of products in the category	"Skin marks in the experimental area that interfere with the evaluation of possible chemical reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); Pregnant or lactating women; Participants with a history of allergies to the material used in the study; History of atopy; Use of vaginal cream; Participants with a history of allergies to cosmetic products in the test category; Recent gynecological surgeries; discharges; People with immunodeficiencies; Kidney, heart or liver transplants; Active cell pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticoid in the experimental area up to 8 days before the beginning of the study. Any condition not mentioned above which, in the opinion of the investigator, may compromise the study evaluation
Note: the participants included are instructed not to change their diet, exercise routine and contraceptive method. Also, do not use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-4m7cpb5	Assessment of quality of anesthesia between two different combinations of anesthetics in outpatient procedures: a clinical trial	Recruiting	Intervention	2023-03-06	<NULL>	<NULL>	5935	Assessment of the quality of anesthesia in patients submitted to ambulatory surgical procedures under sedation with propofol associated with fentanyl or dexmedetomidine: a clinical trial	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2022-11-24	Empresa Brasileira de Serviços Hospitalares - EBSERH	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4m7cpb5	<NULL>	Adult patients; aged between 18 and 65 years; undergoing elective outpatient surgical procedures with sedation performed by an anesthesiologist; procedures should be localized and restricted to the skin and subcutaneous tissue; with an expected duration of between 15 minutes and 1 hour; with ASA classification I to IV; who agreed to participate in the study	Illiterate patients; with some degree of cognitive or mental dysfunction; neurological disease; with a history of allergy to the study drugs; abuse of alcohol and/or illicit drugs or with alterations in renal and/or hepatic function; patients with chronic pain; use of antipsychotic drugs; alpha or beta blockers and/or opioids or who have severe cardiac pathology such as unstable angina; acute myocardial infarction in the last 6 months; heart rate &lt; 50 bpm and systolic blood pressure of 90mmHg; block third-degree atrioventricular or pacemaker; in case of clinical need to use any other medication outside the study protocol or conversion from sedation to general anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-2vz87ym	Assessment of quality of life and functionality in patients with Solid Tumors undergoing Physiotherapy Treatment	Recruiting	Intervention	2025-12-12	<NULL>	<NULL>	8650	Assessment of quality of life and functionality in patients with Solid Tumors undergoing chemotherapy and/or radiotherapy with or without Physiotherapy Intervention: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Centro Universitário Faculdade de Medicina do ABC	<NULL>	<NULL>	<NULL>	A recent cancer diagnosis, being over 18 years old, undergoing chemotherapy and/or radiotherapy, the ability to understand and follow study instructions, providing consent to participate in the trial	Patients with severe physical limitations, patients undergoing physiotherapy treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-4xjvsqh	Assessment of quality of life pain and mouth opening after wisdom tooth extraction using different oral dexamethasone protocols	Recruitment completed	Intervention	2021-12-02	<NULL>	<NULL>	5066	Evaluation of quality of life pain and trismus after lower third molar extraction using different oral dexamethasone protocols	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-30	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4xjvsqh	<NULL>	Patients between 16 and 39 years old;  ASA I, according to the criteria of the American Society of Anesthesiology (ASA); requiring bilateral extraction of lower third molars; dental elements that present similar positioning; impacted teeth Classes 1 and 2; A and B by Pell and Gregory; non-smokers.	history of pericoronitis in the lower third molar region; allergy to any of the medications used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-2ntbth9	Assessment of response to antacids in children with Eosinophilic Esophagitis	Recruitment completed	Intervention	2024-01-29	<NULL>	<NULL>	6752	Evaluation of response to proton pump inhibitors in pediatric patients with Eosinophilic Esophagitis	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2021-05-01	Hospital Santa Casa de Misericórdia de Porto Alegre	Hospital Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2ntbth9	<NULL>	"Children and Adolescents aged 1month to 18 years who were referred to the pediatric endoscopy unit were included. Patients were included when they met the diagnosis criteria for Eosinophilic esophagitis (presenting at least one symptom of esophageal dysfunction; esophageal biopsy with more than 15 eosinophil per high power field) and absence of gastric and duodenal eosinophilia. 4 to 6 biopsies were randomly obtained from the
distal and middle esophagus. Biopsies specimens were also obtained from the antrum and duodenum to exclude gastritis and eosinophilic gastroenteritis"	Children were excluded if they had received prior and recent (up to 1 month before the endoscopy) treatment with proton pump inhibitor; corticosteroids or elimination diet; or if they presented duodenal or gastric eosinophilia or viral, fungal or caustic esophagitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-68mzg3c	Assessment of Sedation in the intensive care unit (ICU): monitoring patients level of consciousness	Recruiting	Intervention	2024-04-18	<NULL>	<NULL>	6948	Use of the consciousness monitor to evaluate Sedoanalgesia in an intensive care unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Patrícia Nunes dos Santos	Hospital Universitário da Universidade Federal do Piauí- HUUFPI	https://ensaiosclinicos.gov.br/rg/RBR-68mzg3c	<NULL>	Age over 18 years old; female and male sex; mechanical ventilation via endotracheal tube; using continuous intravenous sedation at doses above those recommended	Primary neurological disorders (stroke, hypoxic brain injury, intracranial hemorrhage and traumatic brain injury); use of neuromuscular blockers; infection in the central nervous system; extubation; hemodynamic instability; hypoxia; palliative care; post-myocardial revascularization surgery; refusal of the patient or family member to participate; death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-7fpyrp	Assessment of sexual function in low-risk pregnant women	Data analysis completed	Intervention	2016-08-10	<NULL>	<NULL>	951	Evaluation of muscle strength and maternal and perinatal effects of pelvic floor strengthening exercises during pregnancy - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-7fpyrp	<NULL>	Low-risk pregnant women; aged between 18 and 40; literate; capable of getting the MAP checked by vaginal palpation; sexually active (penetrative sex) in the past four weeks, absence of diseases that contraindicate or limit adherence to physical exercise.	Volunteers who have developed diseases that limited exercise;  intolerance physical examination; allergy to condom used in the examination; contraindications of maintaining sexual activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-88c4zpy	Assessment of skin acceptability with perceived efficacy for both adults and children	Not yet recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7299	ORC_110114_EN24-0215-01_Dermal acceptability assessment with perceived efficacy and Dermal and pediatric acceptability assessment with perceived efficacy	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-09	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-88c4zpy	<NULL>	Inclusion Criteria group I participant of both sexes aged 18 and 60; participants with mouth ulcers; participants with mild gingivitis; participants who use orthodontic appliances and/or removable prostheses; be a user of products in the same category; participants willing to follow the trial procedures, who have a cell phone capable of use and with access to the internet network and are available for telephone contacts and/or via WhatsApp and teleservices, with internet access on the days and times determined for the assessments ; participants willing to attend the Clinical Research Center for evaluations, if necessary; participants must understand and agree to the Free and Informed Consent Form (e-TCLE) and consent to their participation; group II participants of both sexes aged between 6 months and 1 year; participants in the first teething phase; vaccination card (updated and up to date); intact skin of the analysis region; be a user of products in the same category; parents or legal representative willing to follow the trial procedures, who have a cell phone capable of use and with access to the internet network and are available for contact by telephone and/or via WhatsApp and teleservice, with internet access on determined days and times for assessments; parents or legal representative of participants willing to attend the Clinical Research Center for evaluations, if necessary, parents or legal representatives of participants must understand, agree and sign the Free and Informed Consent Form (e-TCLE)	Pregnancy or risk of pregnancy/lactation (when women) – for group I; use of anti inflammatory/immunosuppressive/antihistamine drugs up to 3 weeks before selection; skin marks in the experimental area that interfere with the assessment of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevus, sunburn); history of allergies to medical products; active skin pathologies and/or lesions (local and/or disseminated) in the assessment area; immunosuppression by drugs or active diseases; decompensated endocrinopathies; relevant or current clinical history of evidence of alcohol or other drug abuse (for group I); known history or suspected intolerance to products in the same category; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; intense sun exposure up to 15 days before the assessment; employees or children of employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher to be reasonable for disqualification from participation in the study; If yes, it should be described in observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-43vpmr	Assessment of skin and scar quality after Fat Infiltration	Data analysis completed	Intervention	2018-08-10	<NULL>	<NULL>	2113	Assessment of skin and scar quality after Fat Grafting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de Pernambuco - UFPE	Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-43vpmr	<NULL>	Women; abdominoplasty indication; between 20 and 50 years; BMI below 30; previous cesarean scar.	Smokers; patients with systemic disease; use of any medication for chronic use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-5qyszr9	Assessment of skin irritability	Not yet recruiting	Intervention	2022-07-28	<NULL>	<NULL>	5516	Assessment of primary dermal irritability, accumulated dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Medicin Instituto da Pele Ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5qyszr9	<NULL>	Participants of both sexes; age between 18 and 70 years; phototypes: I, II, III and IV (according to the Fitzpatrick adapted scale – Annex 1); intact test region skin; agreement to comply with the trial procedures and to attend the clinic on the days and times determined for the medical evaluations and for the application and reading of the dressings, understanding, consent and signing the Free and Informed Consent Form (FICT)	Participants who have been diagnosed with COVID-19 in the last 4 weeks or who have symptoms such as fever, dry cough, tiredness, body aches or other discomforts; pregnancy or risk of pregnancy and/or lactation (when female); use of anti-inflammatory drugs for 30 days and/or immunosuppressants for up to three months before selection; immunosuppression by drugs or active diseases, decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; predicted intense exposure to sunlight or tanning sessions during the study period; forecast of bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 month before the start of the study; cosmetic and/or dermatological treatment on the body within 3 weeks prior to selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization and irritation to topical product; active skin pathologies (local and/or disseminated) that could interfere with the study results; use of new drugs and/or cosmetics during the study; skin reactivity; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in study products (test or comparative products); history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study, or other conditions deemed by the researcher to be reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-4wkdqx4	Assessment of skin irritability after using a health product	Recruitment completed	Intervention	2022-08-29	<NULL>	<NULL>	6528	Assessment of primary dermal irritability, accumulated dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-30	Medicin Instituto da Pele Ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-4wkdqx4	<NULL>	Participants of both sexes aged 18 to 70 years; Phototype: I, II, III and IV (according to adapted scale); Skin of the application region integrates; Agreeing to follow the test procedures and to attend the clinic on the days and times determined for medical evaluations and for application and reading of dressings; Understanding, consent and signing of the Free and Informed Consent Term (ICF)	Participants who have been diagnosed with COVID 19 in the last 4 weeks or who have symptoms of fever, dry cough, tiredness, body aches or other discomforts; Pregnancy or risk of pregnancy and/or lactation (when women); Use of anti-inflammatory drugs and/or immunosuppressive drugs for up to three months before selection; Immunosuppression by drugs or active disease; Decompensated endocrinopathies; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; Expect intense exposure to sunlight or tanning sessions during the study period; Provision of bathing in the sea, swimming pool or sauna during the study; Practice of water sports during the study; Dermographism; Use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; Aesthetic and/or dermatological treatment on the body within 03 weeks before selection; Scheduled vaccination during the study period or up to 3 weeks before selection; History of sensitization, irritation or photosensitization to topical products; Active skin pathologies (local and/or disseminated) that may interfere with the study results; Skin reactivity; Use of new drugs/cosmetics during the study; Previous participation in studies with the same product; Congenital or acquired immunodeficiency; Relevant medical history or current evidence of alcohol or other drug abuse; Known or suspected history of intolerance to any ingredient in study products (test or comparative product); History of non-adherence or unwillingness to adhere to the study protocol; Employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; Other conditions considered by the researcher as reasonable for disqualification from participating in the study. If yes, it should be described under observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-5f7x539	Assessment of skin irritability after using a health product	Not yet recruiting	Intervention	2024-10-22	<NULL>	<NULL>	7448	ORC_115312_EN24-0384-01 - Assessment of Primary Dermal Irritability, Cumulative Dermal Irritability and Dermal Sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5f7x539	<NULL>	Participants of both sexes; aged 18 to 70 years; skin of the application region integrates; agreeing to follow the test procedures and to attend the clinic on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consent and signing of the Free and Informed Consent Term (ICF)	Pregnancy or risk of pregnancy and/or lactation; use of anti-inflammatory drugs and/or immunosuppressive drugs for up to three months before selection; immunosuppression by drugs or active disease; decompensated endocrinopathies; Personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; expect intense exposure to sunlight or tanning sessions during the study period; provision of bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks before selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitization to topical products; active skin pathologies (local and/or disseminated) that may interfere with the study results; skin reactivity; use of new drugs/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in study products (test or comparative product); history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-7jc7btr	Assessment of skin irritability after using a health product responsible for reinforcing the skin&apos;s protection barrier, preventing microorganisms that cause skin diseases	Not yet recruiting	Intervention	2023-06-22	<NULL>	<NULL>	6428	Assessment of primary dermal irritability, cumulative dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-09	Medicin Instituto da Pele Ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7jc7btr	<NULL>	Participants of both sexes aged 18 to 70* years; Phototype: I, II, III and IV (according to an adapted scale); Skin of the application region is intact; Agreeing to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for applying and reading swabs; Understanding, consent and signature of the Free and Informed Consent Term	Participants who have been diagnosed with COVID 19 in the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; Pregnancy or risk of pregnancy and/or lactation (when women); Use of anti-inflammatory drugs 30 days and/or immunosuppressants for up to three months before selection; Immunosuppression by drugs or active diseases; Decompensated endocrinopathies; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; Expect intense exposure to sunlight or tanning sessions during the study period; Provision of bathing in the sea, swimming pool or sauna during the study; Practice of water sports during the study; Dermographism; Use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; Aesthetic and/or dermatological treatment on the body within 03 weeks prior to selection; Scheduled vaccination during the study period or up to 03 weeks before selection; History of sensitization, irritation or photosensitivity to topical products; Active skin pathologies (local and/or disseminated) that may interfere with the study results; Skin reactivity; Use of new drugs/cosmetics during the study; Previous participation in studies with the same product; Congenital or acquired immunodeficiency; Relevant medical history or current evidence of alcohol or other drug abuse; History of known or suspected intolerance to any ingredient of the study product (test or comparative product); History of non-adherence or unwillingness to adhere to the study protocol; Employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; Other conditions considered by the researcher as reasonable for disqualification from participation in the study. If yes, it should be described in observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-10gm45rd	Assessment of skin irritability after using a medical device	Not yet recruiting	Intervention	2024-05-16	<NULL>	<NULL>	7011	ORC_95616_EN23-0748-01_Assessment of primary dermal irritability, cumulative dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-10gm45rd	<NULL>	Participants of both sexes aged 18 to 70; phototype: I, II, III and IV; skin in the application region is complete; agreement to follow the trial procedures and attend the clinic on the specified days and times; understanding, consent and signature of the free and informed consent form	Pregnancy or risk of pregnancy and/or lactation; use of anti-inflammatory drugs 30 days and/or immunosuppressants for up to three months before selection; immunosuppression by drugs or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; expect intense exposure to sunlight or tanning sessions during the study period; provision for bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks before selection; vaccination scheduled during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitization to topical products; active skin pathologies that may interfere with the study results; skin reactivity; use of new medications/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient of the study product; history of lack of adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or an immediate family member of an employee involved in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-6hnmxv	Assessment of skin irritability.	Recruitment completed	Intervention	2019-10-10	<NULL>	<NULL>	3061	Dermatological assessment of primary dermal irritability accumulated and sensitization.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-08	Ipclin - Pesquisa Clínica Integrada	Vita vert industria e comercio de cosmeticos ltda	https://ensaiosclinicos.gov.br/rg/RBR-6hnmxv	<NULL>	Full skin in the study region (back); Age 18 to 65 years; Gender; male or female, Participants with phototypes I; II; III and IV (according to Fitzpatrick&apos;s classification); Absence of irritation  allergy history to the material used in the study; Have signed the Term of Free and Informed Consent (TCLE); Participants who want to participate in the study without financial gain. They will only be reimbursed for transportation and food expenses.	"Participants who refuse to participate in the study in question; Skin marks in the experimental area that interfere in the evaluation of possible skin reactions (pigmentation disorders; vascular malformations; scarring; increased hairiness; ephelides and nevus in large quantities; sunburn); Dermatoses (local and disseminated) that could interfere with the results of the study; Pregnant women or infants; History of allergic reactions; irritation or intense discomfort feelings to topical products; for health and medicines; Volunteers with a history of allergy to the material used in the study; History of atopy; History of conditions aggravated or triggered by ultraviolet radiation; Immunodeficiency carriers; Kidney; cardiac or hepatic transplanted patients; Intense sun exposure or tanning session up to 15 days prior to initial evaluation; Forecast of intense sun exposure or session of bron during the course of the study; Forecast of bathing; pool or sauna during the study; Participants practicing aquatic sports;
Use of the following topical systemic medicinal products; immunosuppressive; antihistaminic; non-hormonal anti-inflammatory drugs; and corticosteroids up to two weeks prior to selection; Treatment with acid vitamin A and  or its derivatives via oral or topical use up to 01 month before start of the study; Vaccination prediction during the study or up to 03 weeks before the study; Any condition not mentioned above that in the opinion of the investigator could compromise the evaluation of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-64jx632	Assessment of skin irritation after use of a medical device	Not yet recruiting	Intervention	2024-11-18	<NULL>	<NULL>	7519	ORC-131878_EN24-0608-01_Evaluation of primary skin irritability, cumulative skin irritability and skin sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-64jx632	<NULL>	Participants of both sexes; aged 18 to 70 years; phototype: I, II, III and IV; intact skin in the application region; agreement to follow the trial procedures and to attend the Center on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consenting to and signing the Free and Informed Consent Form	Pregnancy or risk of pregnancy/lactation; use of anti-inflammatory drugs 30 days and/or immunosuppressive drugs for up to three months prior to selection; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days prior to the assessment or during the study period; anticipated sea bathing, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 month prior to the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks prior to selection; scheduled vaccination during the study period or up to 03 weeks prior to selection; history of sensitization, irritation or photosensitization to medical devices; active skin pathologies that may interfere with the results of the study; skin reactivity; use of new medications during the study; previous participation in studies with the same physician; congenital or acquired immunodeficiency; relevant clinical history or current evidence of alcohol or other drug abuse; known history or suspected intolerance to any ingredient of the study medical device; history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-2ynphzg	Assessment of skin irritation after use of a medical device	Not yet recruiting	Intervention	2025-11-18	<NULL>	<NULL>	8549	Orc_147832_25-0732-01_assessment of primary dermal irritability, cumulative dermal irritability and dermal sensitization (hript)	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-24	Medcin Pesquisa Clínica Ltda	<NULL>	<NULL>	<NULL>	Participants of both sexes aged 18 to 70 years; phototype: I, II, III and IV, according to the adapted Fitzpatrick scale; intact skin in the application area; agreement to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consent and signing of the informed consent form	Pregnancy or risk of pregnancy/lactation; use of anti-inflammatory drugs 30 days prior or immunosuppressive drugs for up to three months before selection; immunosuppression due to active drugs or diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the evaluation or during the study period; anticipated sea bathing, swimming pool or sauna during the study; practice of water sports during the study; dermatographism; use of oral or topical treatment with vitamin A acid or its derivatives up to 1 month before the start of the study; aesthetic or dermatological treatment on the body within 3 weeks before selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitivity to topical products; active skin pathologies that may interfere with the study results; skin reactivity; use of new medications during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; Relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in the study product; history of non-adherence or unwillingness to adhere to the study protocol; Medcin or sponsoring company employees involved in the study, or a close family member of an employee involved in the study; other conditions considered by the investigator as reasonable grounds for disqualification from study participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:09
RBR-35y8dwr	Assessment of skin, vagina and penis acceptability with perceived efficacy	Not yet recruiting	Intervention	2025-02-04	<NULL>	<NULL>	7704	Orc_135676_en24-0630-01_assessment of dermal, urological and gynecological acceptability with perceived efficacy	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-20	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-35y8dwr	<NULL>	For the female audience: female participants aged 18 to 65 years; sexually active; with vaginal dryness; heterosexual couples in a stable union or civil marriage; intact skin on the vaginal mucosa; user of products of the same category; agreement to follow the trial procedures and attend the Clinical Research Center on the days and times determined for evaluations; understanding, consenting to and signing the Free and Informed Consent Form; for the male audience: male participants aged 18 to 65 years; sexually active; heterosexual couples in a stable union or civil marriage; intact skin on the penile region; user of products of the same category; agreement to follow the trial procedures and attend the Clinical Research Center on the days and times determined for evaluations; understanding, consenting to and signing the free and informed consent form	Pregnancy or risk of pregnancy and/or lactation (for women); participants with erectile dysfunction (for men); sexually transmitted infections, such as: candidiasis, trichomoniasis, gonorrhea, chlamydia or pathologies that compromise the evaluation of the safety of use of the product; use of anti-inflammatory/immunosuppressive/antihistamine drugs up to 3 weeks before selection; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevi, sunburn); atopic or allergic history of products in the same category; active skin pathologies and/or lesions (local and/or disseminated) in the evaluation area; immunosuppression by drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or other drug abuse; known history or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the evaluation; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; other conditions considered by the researcher as reasonable for disqualification from participation in the study. If so, it should be described in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-369svc4	Assessment of sleep quality in athletes of Functional Fitness	Recruiting	Observational	2022-07-26	<NULL>	<NULL>	5510	Assessment of sleep quality in athletes of Functional Fitness	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-02	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-369svc4	<NULL>	Be a male athlete in the Functional Fitness modality with at least 4 months of untrained sports practice, regularly at least 4 months a week;  Be between 18 and 35 years of age; Agree to participate in the signed study and the Free and Informed Consent Form (ICF).	Presence of sleep-associated comorbidities (obstructive sleep apnea, excessive sleepiness disorder, sleep-wake cycle disorders, narcolepsy and cataplexy, sleep disorders, anxiety, depression and obesity) with medical diagnosis and/or drug use (antidepressants) , herbal medicines or those with hormone-like action) for inducing sleep;  Athletes who work at night or have any working condition that affects the assessment of this study;  Athletes using steroids or anabolic peptides;  Withdrawal of the participant at any time in filling in the information regarding the chronotype, daytime sleepiness and sleep quality;  Absence of information or incorrect filling of age; sex; occupation; work shift and/or studies; practice of physical activity that make it impossible to quantify these data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-6j2vvr	Assessment of static balance in lower limb amputees	data analysis completed	Observational	2012-06-15	<NULL>	<NULL>	121	Static stability evaluation in subjects with unilateral transtibial amputation traumatic.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6j2vvr	<NULL>	"Amputees prostheses for more than one year and not amputated;
Ability to walk without assistive devices for walking;
Use prosthesis aligned with dynamic Sach ® foot."	Hypertension, cardiovascular disease, or any condition that alters the quality of gait.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-2dch2qr	Assessment of the absorption and antioxidant effect of vitamin C microparticles in elite football players	Recruitment completed	Intervention	2024-03-28	<NULL>	<NULL>	6900	Ascorbic acid microcapsules: study of absorption and antioxidant activity in vivo	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2dch2qr	<NULL>	Age 18-25 years; male; regular physical training for 7 days a week and 90-120 minutes a day; participation in national or international competitions; absence of chronic non-communicable diseases; lack of consumption of nutritional supplements	Diagnostic of chronic non-transmissible diseases; consumption of nutritional supplements with vitamin C within the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-8pqgrpn	Assessment of the benefits of Health Education with educational material for patients with Parkinson&apos;s Disease	Recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7993	Assessment of the benefits of a validated educational manual for patients with mild to moderate Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-28	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8pqgrpn	<NULL>	Have a diagnosis of Parkinson&apos;s disease according to the Movement Disorders Society criteria; Parkinson&apos;s disease stage from 1 to 3, according to the modified Hoehn and Yahr (HY) scale; be literate; Be ≥40 years old; female or male gender	Diagnosis of multiple sclerosis, acute disseminated encephalomyelitis, parkinsonism plus, cerebrovascular disease with motor sequelae, or Guillain-Barré syndrome; dementia syndrome of any etiology according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); schizophrenia with hospitalization, psychotic episode, or suicidal ideation in the last 6 months; Bipolar affective disorder with hospitalization or episode of mania, hypomania, or depression in the last 6 months; depression with hospitalization, suicidal ideation, or a psychotic episode in the last 6 months; myocardial infarction with or without ST-segment elevation in the last 12 months; myocardial revascularization surgery or percutaneous angioplasty in the last 12 months; uncontrolled arrhythmia; severe chronic obstructive pulmonary disease or oxygen dependency; Heart failure with functional reduction and symptom classification in stage III or IV; resting blood pressure ≥160 × 100 mmHg; implantable cardioverter-defibrillator; severe chronic kidney disease (creatinine clearance &lt;30 mg/dl); proliferative retinopathy due to type 2 diabetes mellitus; peripheral neuropathy with motor impairment; moderate to severe hearing impairment: inability to maintain a conversation or need for lip reading; moderate to severe visual impairment: minimum visual acuity of 20/70 on the Snellen scale; active cancer or undergoing cancer treatment; alcohol consumption &gt;14 drinks per week; living with individuals participating in the same study; thromboembolism without the use of anticoagulants; significant weight loss (10% of usual weight) in the last 6 months; lack of family support to participate in the study; mini-Mental State Examination (MMSE) score less than 25 for patients with 1 to 4 years of education, less than 27 for patients with 5 to 8 years of education, less than 28 for patients with 9 to 11 years of education, or less than 29 for patients with more than 11 years of education	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-6fyzgd	Assessment of the benefits of MASQUELIER&apos;s® Original OPCs within a farmer population highly exposed to pesticides in South Brazil	Not yet recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2746	Double-blind randomized clinical trial assessment of the benefits of MASQUELIER&apos;s Original OPCs within a farmer population highly exposed to pesticides in South Brazil	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-06-07	International Nutrition Company (INC Agency BV)	International Nutrition Company (INC Agency BV)	https://ensaiosclinicos.gov.br/rg/RBR-6fyzgd	<NULL>	It will be included individuals with current agrochemical exposure and with a history of exposure to agrochemicals as a labor activity for at least five years. The selection of farmers has the support of the Department of Health of the Municipality of Santo Amaro da Imperatriz. Another supporting agent will be the Jorge Duprat Figueiredo Foundation for Safety and Occupational Medicine (FUNDACENTRO).	(1) Any dietary supplements with potential effects on antioxidant and inflammatory status are prohibited from 4 weeks before inclusion into this study and during the study period; (2) Any other investigational product is prohibited from 4 weeks before inclusion into this study and during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-7zrm8fd	Assessment of the bowel from women that underwent surgery for intestinal endometriosis	Recruiting	Observational	2024-04-16	<NULL>	<NULL>	6942	Intestinal functional evaluation of women undergoing surgical treatment for deep Intestinal Endometriosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zrm8fd	<NULL>	Female patients; with clinical and radiological suspicion of deep endometriosis with intestinal involvement, who underwent imaging investigation using transvaginal ultrasound with intestinal preparation to map the endometriosis or Nuclear Magnetic Resonance Imaging with the same intestinal preparation technique; and had suspected intestinal involvement under 4 cms; with a degree of circumference in the intestinal involvement less than 40% and with a distance from the lesion less than 15 cms from the anal verge	Patients who do not present clinical and diagnostic characteristics in the evaluation that include them in the indications for the lumpectomy technique; the impossibility of completing the questionnaire within the allotted time (PRE, P3, P6 and P12); failure to complete the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-9x99fg8	Assessment of the degree of muscle injury and impairment of strength and movement in Knee Replacement Surgery using a pneumatic tourniquet in an optimized way	Data analysis completed	Intervention	2022-02-11	<NULL>	<NULL>	5207	Assessment of the degree of muscle injury and impairment of quadriceps motor function with the use of an optimized tourniquet in Total  Knee Arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Instituto Nacional de Traumatologia e Ortopedia INTO	Instituto Nacional de Traumatologia e Ortopedia INTO	https://ensaiosclinicos.gov.br/rg/RBR-9x99fg8	<NULL>	The study will include patients with knee osteoarthritis glued to the cemented TKA and who agreed to participate in the research by signing the Informed Consent Form (ICF).	Patients with uncontrolled sitemic arterial hypertension and chronic heart disease, smokers, patients with a history of previous surgery on the same joint, patients with evidence of joint infection, patients with congenital or acquired coagulopathies, patients on chronic use of oral and anticoagulants will be excluded from the study.  corticosteroids, patients with malignant neoplasms and autoimmune diseases, patients with indication for revision surgery and patients with severe axis deviation of the lower limbs (varus&gt; 10 ° and varus&gt; 15 °).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-967k5py	Assessment of the effectiveness of cognitive rehabilitation as a therapeutic strategy for patients diagnosed with COVID19 and cognitive symptoms	Recruiting	Intervention	2022-08-09	<NULL>	<NULL>	5536	Clinical trial on the effect of cognitive rehabilitation in individuals with COVID-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-967k5py	<NULL>	Participants residing in Juiz de Fora (MG) with a confirmed diagnosis of COVID-19 by PCR within a period of up to six months before inclusion in the study; over 18 years of age; and literate (enough to guarantee the reading of words or phrases in the execution of the cognitive tests).	Participants who present a neurological and/or psychiatric diagnosis that justify previous impairments or that make it impossible to adhere to and understand the cognitive assessment tasks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-84jx98	Assessment of the effects of TENS in patients with low back pain treated with acupuncture.	Recruiting	Intervention	2016-09-12	<NULL>	<NULL>	996	The assessment of the effects of analgesia in transcutaneous electrical stimulation associated with acupuncture in patients with chronic low back pain.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-10	Universidade Federal de Pernambuca - UFPE/ Brasil	Universidade Federal de Pernambuca - UFPE/ Brasil	https://ensaiosclinicos.gov.br/rg/RBR-84jx98	<NULL>	Patients aged from 40 years; both sexes; with a history of low back pain for more than three months.	In addition to not meet the inclusion, they will also be considered affected or carriers of any concomitant arthropathy; those who are undergoing cancer treatment; which have chronic diseases or changes in neurological examination as Parkinson&apos;s disease, Alzheimer&apos;s and Stroke rehabilitation. Also excluded are patients who do not accept (or their relatives) sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-8dcymd4	Assessment of the female intimate area before and after the use of treated and untreated menstrual pads	Recruiting	Intervention	2025-08-29	<NULL>	<NULL>	8239	Crossover clinical study to evaluate the potential of a pH-buffered, prebiotic treated menstrual pad to provide benefits to the skin and intimate microbiome (E008750A)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-22	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8dcymd4	<NULL>	Females; 18 to 45 years old; in good general health, with regular monthly menstrual cycles; who menstruates up to 5 to 6 days. Participants must have healthy and intact skin in the test areas and be willing to comply with study requirements	Participants who are pregnant or intending to become pregnant during the study; history of chronic or currently active gynecological pathologies or urogenital infections in the last 3 months; used systemic and/or topical antibiotics, antifungals, and/or corticosteroids within 4 weeks prior to visit 1; any other medical condition or history that may compromise the study results or the subject’s safety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-4f7w4b6	Assessment of the female intimate area before and after the use of treated and untreated pantyliners	Recruitment completed	Intervention	2025-02-06	<NULL>	<NULL>	8233	Single-center, parallel, single blind clinical study to evaluate the urogenital microbiota and skin condition before and after wearing treated pantyliners with prebiotic and untreated control pantyliner	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-09	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	https://ensaiosclinicos.gov.br/rg/RBR-4f7w4b6	<NULL>	Females; 18 to 45 years old; in good general health, with regular monthly menstrual cycles who are not expected to menstruate during the study; participants with healthy and intact skin in the test areas; and be willing to comply with study requirements	Participants who are pregnant or intending to become pregnant during the study; history of chronic or currently active gynecological pathologies or urogenital infections in the last 3 months; used systemic and/or topical antibiotics, antifungals, and/or corticosteroids within 4 weeks prior to visit 1 and throughout the study; any other medical condition or history that may compromise the study results or the subject’s safety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-106nvs7h	Assessment of the healing of venous ulcers of the lower limbs through the use of brazilian mangrove plant extract cream	Recruitment completed	Intervention	2024-03-27	<NULL>	<NULL>	6898	Assessment of the speed of wound healing of venous ulcers through the use of brazilian mangrove plant cream	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2022-08-01	Jéssica Guido de Araújo Sá	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-106nvs7h	<NULL>	Patient aged 18 or over; patients with venous ulcers in the lower limbs.	Patients under 18 years of age; patients who do not sign the Consent Form; patients with ulcers of other etiologies or mixed; patients with factitious dermatitis; or with cognitive deficits or previous psychiatric disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-2624r4	Assessment of the health of elderly and young people who exercise	Recruiting	Intervention	2017-12-06	<NULL>	<NULL>	1511	Cell health of elderly and elderly people involved in programs resistance training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-14	UNESP-Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	UNESP-Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-2624r4	<NULL>	Signature of the informed consent form;both genders; over 60 years old; do not have chronic disabling diseases; not be bedridden; institutionalized or hospitalized; have their own mobility	Osteoarticular limitations that impede the execution of the resistance training program; cognitive limitations that prevent the accomplishment of the proposed evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-94vwv2	Assessment of the hydration potential of a gynecological product and evaluation of the appearance of allergies or irritations.	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2951	Evaluation of Dermal and Gynecological Acceptability of a Medical Device (Irritability and Sensitization in the Genital Mucosa) and Evaluation of the Moisturizing Potential by Corneometry	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-12	Medcin Instituto da Pele Ltda.	Medcin Instituto da Pele Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-94vwv2	<NULL>	Healthy women complaining of vaginal dryness; Age range between 45 and 65 years; Intact skin in the region of product analysis; No history of reaction to topical products	Pregnancy or risk of gestation and or lactation; pathologies and or cutaneous lesions such as psoriasis, sensitive skin, skin cancer, rosacea, atopic dermatitis or other medical criteria to be considered at the time of evaluation; hyperpigmentation in the area of Test that interfere in the evaluation of possible reactions vascular malformations, scars, increased pilosity and large amount of nerves; Active cutaneous pathologies and or lesions local and or disseminated in the evaluation area; use of the following Topical or systemic medications: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to 30 days before selection or considering immunosuppressants, the interval should be 3 months before selection; Decompensated endocrinopathies; Immunosuppression by drugs or active diseases; Relevant clinical history or current evidence of abuse of alcohol or other drugs; Aesthetic or dermatological treatment in the evaluation area up to 04 weeks before selection; Alteration of hygiene habits up to 04 weeks before selection, such as: Alteration of brand and type of body and intimate soaps and etc. ; Atopic or allergic antecedents to category products; Known history or suspected intolerance to Products of the same category; Cutaneous markers in the experimental area that interfere in the evaluation of possible cutaneous reactions vascular malformations, scars, increased pilosity and nevus in large quantity; Participants with Known congenital or acquired immunodeficiency; Professionals directly involved in conducting the present study both from the research center and from the sponsor; Other conditions considered by the appraiser physician as reasonable for Disqualification of the study&apos;s participation. If yes, it should be described under observation in the clinical form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-8cjjpgm	Assessment of the impact of sanitation on the prevention of urban leptospirosis.	Recruiting	Intervention	2021-10-31	<NULL>	<NULL>	5010	Improved sanitation interventions to prevent urban leptospirosis transmission	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-16	Wellcome Trust	Instituto de Saúde Coletiva (ISC) - UFBA	https://ensaiosclinicos.gov.br/rg/RBR-8cjjpgm	<NULL>	Sleeping ≥3 nights a week in a study household; They are ≥18 years old for leptospirosis study and between 0.6 month to 17 years to exploratory outcomes; living in the area for at least 6 months; understand and agree to participate in the study by signing the informed consent procedures. Participants who agree to use GPS for 24 hours in order to monitor their movements; signing a specific informed consent procedure.	Residents who being less than 18 years old (For the Leptospirosis study); residents that sleep less than 3 nights a week in a residence on site; residents who refuse or are unable to provide information, biological sample collection; residents who do not provide written informed consent to participate in the study; residents with limited mental health problems or other problems that have implications for survey responses or participation in any other phase of research activity; legal guardians who do not agree, in writing, with the participation of individuals under 18 years of age; residents with reduced mobility due to physical and mental conditions, which do not allow displacement to the neighborhood or other places in the community (previous or during the data collection period).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-7v33r6x	Assessment of the impact of using more affordable Videolaringoscopes in airway management	Not yet recruiting	Intervention	2024-04-16	<NULL>	<NULL>	6940	Evaluation of the impact of the use of 3d printed Videlaryngoscopes on airway management	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-10	Hospital Santa Izabel - Santa Casa da Misericórdia da Bahia / Professor Doutor Celso Figueirôa	Instituto de Ensino e Simulação em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7v33r6x	<NULL>	Doctors participating in the advanced cardiology life support course at Health Education and Simulation Institute; who agree to the study and sign the Free and Informed Consent Form	Refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-9cy6py	Assessment of the implementation of an educational action focused on patients with poor anticoagulation control  in two teaching hospitals	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2567	Assessment of of the implementation of an Educational Intervention focused on patients with poor anticoagulation control using vitamin K antagonist in two teaching hospitals	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Universidade Federal de Minas Gerais	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9cy6py	<NULL>	Eighteen years of age or more, both sexes, follow up in the anticoagulation clinics for at least six months, valvular or non valvular atrial fibrilation  as indication for warfarin use and time in therapeutic range below the percentage of sixty	Bedridden patients or limitation of locomotion that compromises the attendance to scheduled visits, blind or deaf, aphasia or other speech disorders that could hinder communication during study, dementia diagnosis reported in medical records, less than two international normalized ratio values in the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-83wwpx	Assessment of the influence of the use of live microorganisms on the absorption and production of soy isoflavone substances in women with menopausal symptoms	Recruiting	Intervention	2016-10-14	<NULL>	<NULL>	1037	Assessment of the influence of probiotics in absorption and production of soy metabolites in menopausal women with climateric symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-14	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-83wwpx	<NULL>	Women between 40 and 60 years of age; latest menstrual period has occurred at least 12 months previously; follicle-stimulating hormone (FSH) levels are higher than 40mIU/mL; estradiol levels are lower than 20 pg/ml;currently present symptoms of estrogen deprivation.	History of chronic conditions such as Type 2 diabetes mellitus; cardiovascular or gastro-intestinal disorders; contraindications to hormone replacement therapy; soy-intolerant; vegetarians; undergone bariatric surgery; undergone hysterectomy; undergone hormone replacement therapy; oral contraceptives; antibiotics or lipid-lowering drugs in the previous 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-2dfqmr2	Assessment of the knowledge acquired by nursing students on the topic of Leadership through an Online Module	Recruiting	Intervention	2024-02-26	<NULL>	<NULL>	6813	Effect of the Online Module on the acquisition of nursing students&apos; knowledge about Leadership: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-23	Departamento de Enfermagem - Universidade Federal do Rio Grande do Norte	Departamento de Enfermagem - Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2dfqmr2	<NULL>	People aged 18 or over; both genders; being a student in the seventh period of the Universidade Federal do Rio Grande do Norte - UFRN; Nursing course in the semester of 2024.1; have not consumed content on Leadership and/or have not taken the Health Services Management subject or equivalent subject	Students in the seventh period; who have already completed other degrees, stricto sensu or lato sensu postgraduate courses, extension courses, free courses, short courses or events that address the topic of leadership	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-3q85m7g	Assessment of the level of stress and anxiety in assisted reproduction using Reiki	Recruitment completed	Intervention	2024-03-18	<NULL>	<NULL>	6859	Assessment of the level of stress and anxiety with the application of Reiki in the treatment of assisted reproduction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3q85m7g	<NULL>	Age between 18 and 42 years;  undergoing infertility treatment at the marital infertility outpatient clinic of HCFMRP-USP; participated in the complete basal cycle; regardless of race; religion; creed; socioeconomic status; schooling; parity; Body Mass Index	Women who withdrew from participating in the research; expressed rejection of the proposed objectives; women who have modified the therapeutic path proposed by the method	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-3hf227	Assessment of the pain level  of Benzathine Benzylpenicillin administered in the region ventrogluteal (hip) vs. dorsogluteal	Recruitment completed	Intervention	2015-07-24	<NULL>	<NULL>	555	Assessment of acceptance of intramuscular injection of penicillin in the region ventral gluteal in emergency units in Goiânia - Goiás	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-25	Faculdade de Enfermgem da Universidade Federal de Goiás	Faculdade de Enfermgem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3hf227	<NULL>	Present the prescription of Benzylpenicillin; be over 18 years old; be served in the medication room of two  Centro de Atendimento Integrais a Saúde (CAIS) of the eastern region of Goiânia.	Have an injury on the skin or muscles of the buttock; present prescription of procaine penicillin associated with Benzylpenicillin; have psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-542d26f	Assessment of the physical and functional capacity of burnt subjects at hospital discharge and follow-up outpatient return	Recruiting	Observational	2021-12-29	<NULL>	<NULL>	5130	Assessment of the physical and functional capacity of burnt subjects at hospital discharge and follow-up outpatient return	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-09	Universidade Estadual de Londrina-UEL	Programa de Pós-Graduação em Ciências da Reabilitação- UEL	https://ensaiosclinicos.gov.br/rg/RBR-542d26f	<NULL>	Age 18 years or over; both genders; admitted to the Burn Treatment Center of the University Hospital of Londrina, with a diagnosis of burn of any length and depth of the body surface; absence of the following conditions: visual deficit; osteo-neuromuscular dysfunction that compromises gait, balance or shoulder range of motion, unrelated to the burn; severe cardiovascular and/or respiratory disease prior to the burn; acceptance to participate in the research, signing an informed consent form.	Patients unable to complete the study protocol for any reason, such as inability to answer questions asked during testing or excessive pain during testing; those who wish to withdraw from the study at any time.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-66j5yf	Assessment of the potential for primary irritation and skin sensitization without the use of four etectrodes	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4308	Assessment of the Skin Primary and Cumulative Irritation Potential and Skin Sensitization Potential of Four Electrodes (071075-01/04), Under Controlled and Maximized Conditions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-30	3M do Brasil Ltda	Allergisa Pesquisa Dermato-Cosmética Ltda	https://ensaiosclinicos.gov.br/rg/RBR-66j5yf	<NULL>	healthy subjects; intact skin on test site; agreement to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; ability of giving consent for participation in the study; aged from 18 to 70 years old; phototype (Fitzpatrick): I to IV; any gender.	"pregnancy or breastfeeding; any skin marks on the test site that might interfere with the assessment of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased pilosity, and great amounts of ephelides and nevus, sunburns); active dermatosis (local or disseminated) that might interfere with the results of the study; antecedents of allergic reactions, irritation or sensation of intense discomfort to topical products: cosmetics, health products or medications; atopy antecedents, (atopic dermatitis, allergic rhinitis, allergic bronchitis, allergic conjunctivitis, etc.); discomfort sensation with temperature changes (too hot/too cold) and/or when you are in the air conditioner; subjects with history of allergy to the materials used in the study; history of pathologies aggravated or triggered by ultraviolet radiation; subjects suffering from immunodeficiencies; intense exposure to sunlight or to sun tanning sessions up to 15 days before the initial assessment; intention of being intensely exposed to sunlight or to sun tanning sessions during the study period; forecast to sea bath, to go to the pool or bathtub during the study; subjects who practice water sports; dermographism;aesthetic and/or dermatological treatment performed on the body within 03 weeks before selection; use of the following topical or systemic medications: immunosuppressant drugs, antihistamines, non-hormonal antiinflammatory drugs, and corticosteroids up to 2 weeks before selection; in case of deposit corticosteroids, up to 1 month before selection; oral or topical treatment with vitamin A acid and/or its derivatives up to 1 month before the study started; forecast  of vaccination during the study or up to 03 weeks before the study; be currently taking part or have already participated in another clinical study which was concluded less than 07 days before selection, if the previous study is an in-use study; be currently taking part or have already participated in another clinical study which was concluded less than 21 days if the previous study was a Compatibility study or an Adverse Reaction Investigation; any conditions not mentioned above which the investigator finds compromising to the evaluation of the study; history of lack of adherence or unwillingness to adhere to the study protocol;
professionals who are directly involved in the performance of the current protocol as well as their relatives."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-7yrysy5	Assessment of the presence of protection against yellow fever in children and adults after administration of reduced doses of the 17dd-yellow fever vaccine	Recruiting	Observational	2025-10-02	<NULL>	<NULL>	8347	Observational study of the long-term duration of humoral and cellular immunity in children and adults after primary yellow fever vaccination 17dd using a fractional dose (1/5 of the standard dose)	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Instituto René Rachou da Fundação Oswaldo Cruz	Instituto Nacional de Infectologia Evandro Chagas da Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-7yrysy5	<NULL>	Female and male participants; who participated in the study “Humoral and cellular immunity in children and adults subjected to 17DD yellow fever primary vaccination with a fractional dose,” conducted in the state of São Paulo in 2018; who had a negative yellow fever seroneutralization result prior to vaccination in 2018; participants must be at least 10 years old in 2025; participants must agree to provide their name, address, telephone number, and other personal information to allow contact; participants must be able to understand and sign the assent form or the informed consent form	Participants who received another dose of the yellow fever vaccine after 2018 with confirmation in the immunization record; participants diagnosed with autoimmune diseases or neoplasms after 2018, or who are using immunomodulatory drugs; participants presenting with a febrile illness at the time of sample collection; participants who have received the dengue or cholera vaccine; participants who were diagnosed with yellow fever after vaccination in 2018	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-9gm2fgf	Assessment of the quality of life of people who had lower Wisdom tooth Extraction	Terminated	Intervention	2024-08-26	<NULL>	<NULL>	7268	Assessment of the quality of life of individuals undergoing Extraction of impacted Third Molars in the mandible	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9gm2fgf	<NULL>	Adults aged between 18 and 45, of both sexes; in ASA in group I; with indication of bilateral extraction of lower third molars; The right and left lower third molars of the included individuals must present the same degree of inclusion according to the classification of Pell and Gregory (1933) determined by means of panoramic radiography or cone beam computed tomography	Patients who are allergic to NSAIDs (nimesulide or etoricoxib) and/or corticosteroids (dexamethasone); signs of infection at the surgical site; chronic users of analgesics and/or anti-inflammatories; smokers; pregnant or breastfeeding women; patients who did not fit into the surgical or anesthetic planning and patients who withdrew from participating in the research at any time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-6rtdrn	Assessment of the quality of the automatic stimulus electrodiagnosis test to detect diseases in peripheral nerves	Recruiting	Observational	2020-08-20	<NULL>	<NULL>	4442	Reproducibility Assessment of an automated system for neuromuscular electrophysiological analysis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-08-24	Paulo Eugênio Silva	Instituto de Gestão Estratégica de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-6rtdrn	<NULL>	"Healthy. Individuals with no history of neuromuscular or orthopedic disease; Intensive care unit. Patients with traumatic brain injury;
Sedated patients with at least 6 days of invasive mechanical ventilation; Participants aged between 18 and 60 years."	Healthy. Pregnant women; Individuals with skin lesions in the area to be assessed; Intensive care unit. Pregnant women; Patients with skin lesions and or fractures in the area to be assessed; Use of neuromuscular blocker on the day of the assessment; Patients with brain death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:12
RBR-4zrwtz	Assessment of the risks and benefits of Vancomycin use in patients with infection	Recruiting	Observational	2018-01-18	<NULL>	<NULL>	1579	Evaluation of the safety and efficacy of Vancomycin use in septic patients admitted to the Clinical Hospital of the Botucatu Medical School - UNESP	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Departamento de Clínica Médica da Faculdade de Medicina de Botucatu	Departamento de Clínica Médica da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4zrwtz	<NULL>	Septic patients older than 18 years using vancomycin for at least 48 hours admitted to 2 intensive care units and 4 wards (clinical and surgical). Patients using vancomycin and requiring acute renal support will be included in an additional vancomycin pharmacokinetic / pharmacodynamic research protocol	Patients under 18 years old; Pregnant women;  stage 5 CKD (creatinine clearance less than 15 mL / min, according to the MDRD formula); Kidney transplant recipients; Patients taking vancomycin for less than 48 hours and those admitted or who progressed with acute kidney injury prior to the start of their use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-22xgxrw	Assessment of the safety and benefits of joint injections with regenerative therapies in people with hemophilic arthropathy	Recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9170	Evaluation of the efficacy and safety of intra-articular infiltration of regenerative therapies in hemophilic arthropathy	<NULL>	1-2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-23	Universidade Federal do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; diagnosis of hemophilia A or B (moderate or severe); presence of hemophilic arthropathy in at least one joint (knee, ankle, elbow, shoulder, or hip); regular follow-up at a hemophilia treatment center; ability to provide informed consent; availability for follow-up assessments at baseline, 3 and 6 months	Presence of active local or systemic infection (including septic arthritis or cellulitis) at the time of intervention; recent orthopedic procedure in the target joint during the study period; immunosuppression; pregnancy or suspected pregnancy; significant joint instability or suspected fracture in the target joint; withdrawal of consent during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-7t8qnj8	Assessment of the safety and cost of using the medication Pamidronate when used in a one-day or three-day treatment regimen in patients with the rare disease called Fibrous Dysplasia of Bone	Recruiting	Intervention	2023-04-03	<NULL>	<NULL>	5982	Assessment of the safety and cost of using Pamidronate in a single-dose regimen rather than a fractional dose, in patients with Fibrous Dysplasia of Bone	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual Paulista -  UNESP / Faculdade de Medicina de Botucatu - FMB	Universidade Estadual Paulista -  UNESP / Faculdade de Medicina de Botucatu - FMB	https://ensaiosclinicos.gov.br/rg/RBR-7t8qnj8	<NULL>	Bone fibrous dysplasia; bone pain; expanding bone lesion	Creatinine clearance below 30mg/dL	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-6vpxz6	Assessment of the safety and efficacy of a nasal spray product.	Not yet recruiting	Observational	2019-06-10	<NULL>	<NULL>	2743	Subjective evaluation of the clinical efficacy of a nasal spray.	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Ipclin - Pesquisa Clínica Integrada	Master ind. e com. de produtos odontológicos e farmacêuticos ltda	https://ensaiosclinicos.gov.br/rg/RBR-6vpxz6	<NULL>	"Age: 18 to 65 years
Female and male. Full skin in the study region (nose). Phototypes I to IV. Participants who agree to adhere to the procedures and requirements of the study and to attend the Institution on the days and times determined for the evaluations. Participants who have the capacity to consent to their participation, signing the Informed Consent Term (TCLE). Participants who agree not to use products of the same category during the conduct of this research. Participants who have not participated in similar studies for at least 2 months prior to the study."	"Diseases or medications that may directly interfere with the study or endanger the health of the research participant, according to the physician responsible for including study participants.
Immunodeficiencies. Renal, cardiac or hepatic transplanted. Erythema solar in the study region due to intense sun exposure 1 month before the study. Current use of the following medicines: corticoids, antihistamines, immunosuppressants, retinoids, anti-inflammatories. Participants who refuse to participate in the study in question.
Any condition that could interfere with the evaluations according to the investigator of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-74hk74	Assessment of the safety of a dental product	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2712	Evaluation of dental acceptability of product with appreciability for health under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-21	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-74hk74	<NULL>	Age: 18 to 65 years. Female and male. Phototypes: I to IV. Healthy mouth except for oral affection (cold sore). Perform brushing at least 3 times a day	"Active dermatoses (local and disseminated) that may interfere with the results of the study. Screening or nursing. Allergy or reactivity for the category of tested products. Participants with a history of allergy to the material used in the study. History of atopy. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Use of the following topical systemic medicinal products: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection. Abnormality or symptom in the region. Diabetes. Use of orthodontic appliance. Prediction of vaccination during the study or up to 03 weeks before the study. Be participating in another study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. Have performed or performed oral surgeries during the study. History of lack of adherence or unwillingness to adhere to the study protocol;
Professionals directly involved in the realization of this protocol and their relatives."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-3znpr6	Assessment of the safety of a dental product	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2716	Evaluation of the dental acceptability of the product for health under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-20	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-3znpr6	<NULL>	Age: 18 to 65 years. Female and male. Phototypes: I to IV. Healthy mouth except for oral affection (cold sore). Perform brushing at least 3 times a day	Active dermatoses (local and disseminated) that may interfere with the study results. Pregnant or nursing mothers. Allergy or reactivity for the category of tested products. Participants with a history of allergy to the material used in the study. History of atopia.Portadores de inmunodeficiencias.Transplanted renal, cardiac or hepatic. Use of the following systemic topical medications: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection. Abnormality or symptom in the region. Diabetes. Use of orthodontic appliance. Prediction of vaccination during the study or up to 03 weeks before the study. Be participating in another study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. Have performed or performed oral surgeries during the study. History of absence of adherence or unwillingness to adhere to the study protocol. Professionals directly involved in the realization of this protocol and their relatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-7gfvn3y	Assessment of the self-care capacity of informal caregivers of elderly people living with Dementia	Not yet recruiting	Intervention	2023-12-22	<NULL>	<NULL>	6680	Self-care capacity of informal caregivers of elderly people with Dementia: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-7gfvn3y	<NULL>	Being 18 years of age or older. Both genders. Being the main informal caregiver for elderly people with dementia. Being an informal caregiver for an elderly person with dementia for at least one year. Have access to a smartphone and internet and know how to use a messaging app	Have difficulty communicating, listening and understanding the questions asked by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-5fn873	Assessment of the spinal anesthesia technique for benign surgery of the anus and rectum	Recruitment completed	Intervention	2019-04-12	<NULL>	<NULL>	2595	Effectiveness of modified sacral spinal anesthesia in ambulatory hemorrhoidectomies: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-28	Universidade Federal de Alagoas	Hospital Universitário Professor Alberto Antunes - HUPAA/UFAL	https://ensaiosclinicos.gov.br/rg/RBR-5fn873	<NULL>	Patients with grade III to IV hemorrhoids, anal fissure and anorectal fistula with an indication for surgical treatment that meet the following inclusion criteria: age greater than or equal to 18 years and less than or equal to 65 years of age, with I to III American Society of Anesthesiology - ASA.	Contraindication to spinal anesthesia and outpatient stay (absence of telephone contact, difficulty in transportation of locomotion, physical residence in another municipality of anesthetic-surgical intervention and outpatient admission with absence of prescribed postoperative medications), current anorectal inflammatory disease, cognitive disability to respond to the forms, any decompensated clinical pathology, neurological pathology, diabetes mellitus, urge urinary incontinence, previous prostate, renal or urologic surgery and drug allergy or any contraindication to the following drugs: propofol, midazolam, dipyrone, non-hormonal anti-inflammatory drugs, paracetamol, codeine, polyresulin and cinchocaine hydrochloride.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-5jmx32v	Assessment of the Strict Oral Hygiene Phase in the periodontal condition of obese and eutotrophic individuals diagnosed with Periodontitis	Recruiting	Intervention	2024-03-11	<NULL>	<NULL>	6842	Effect of Strict Hygienic Phase prior to Periodontal Therapy on the periodontal and general condition of Obese and Eutrophic patients with Periodontits: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5jmx32v	<NULL>	Individuals diagnosed with stage III or IV periodontitis, either eutrophic or with obesity grade I according to the World Health Organization (WHO) criteria; both genders; aged between 30 and 60 years; presence of at least 10 teeth in the oral cavity. These participants should not have a history of systemic disease (HIV, hepatitis), be pregnant or lactating, or have undergone antibiotic therapy in the last three months, periodontal treatment in the last six months, orthodontic appliance use, or be undergoing nutritional therapy	Those affected by Covid-19 during the study period will be excluded; participants who do not complete all data collection assessments; initiate nutritional treatment; who do not follow oral hygiene guidelines during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-7kp4x6p	Assessment of the superiority of using Bicalutamide 50 mg orally versus Spironolactone 100 mg orally for treatment of Female Baldness	Recruitment completed	Intervention	2025-03-26	<NULL>	<NULL>	7867	Assessment of the superiority of efficacy of using Bicalutamide 50 mg orally versus Spironolactone 100 mg orally for treatment of Female Pattern Alopecia: double-blind and randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-09-01	Clinica Sanabria Transplante e Restauração Capilar	Clinica Sanabria Transplante e Restauração Capilar	https://ensaiosclinicos.gov.br/rg/RBR-7kp4x6p	<NULL>	Females; age between 17 and 60 years; diagnosis of female pattern alopecia stages II to V of the Sinclair scale	Patients who have undergone previous treatment for hair loss in the last four months; diagnosed with high blood pressure, heart disease, liver disease or kidney disease; with other causes of hair loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-37qx63d	Assessment of the tolerance and safety of Prescription of different doses of Psilocybin in Healthy adults.	Not yet recruiting	Intervention	2024-02-17	<NULL>	<NULL>	6791	Assessment of the tolerability and safety of Administration of different doses of Psilocybin in Healthy adults.	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2024-05-01	Biocase Brasil	Instituto Alma Viva	https://ensaiosclinicos.gov.br/rg/RBR-37qx63d	<NULL>	Adults without comorbidities aged between 21 and 65 years from both gender	Participants who meet any of the following exclusion criteria are not eligible for the study including use of medications that may interfere with the study drug, history of heart, liver, kidney disease, history of cancer or organ transplant, insulin dependent diabetes or uncontrolled diabetes, gastrointestinal disease that may interfere with the absorption of the substance orally, current or past history of psychiatric disorders as schizophrenia, psychotic disorder, bipolar disorder, personality disorder, first degree family history of psychiatric disorders, seizures or fainting, creatinine elevation, nicotine dependence that would prevent an individual from being nicotine-free for 7 to 10 hours during the dosing period, women who are pregnant or intending to become pregnant during the study or who are currently breastfeeding, chemical dependency or abuse of alcohol or illicit drugs in the last 12 months, platelets disorders,  clinically significant anemia, liver injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-6jcj8k3	Assessment of uterine scar immediately after cesarean section. Influence of wire with barbs on ultrasound of the scar defect	Recruitment completed	Intervention	2024-02-21	<NULL>	<NULL>	6797	Early assessment of cesarean section scar. Influence of Barbed Wire on the ultrasound characteristics of the Niche	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-12	Faculdade de Medicina - Universidade Federal de Mato Grosso do Sul	Hospital Universitário Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-6jcj8k3	<NULL>	Pregnancy. Age 18 years old and over. Without cesarean section	Uncontrolled gestational diabetes. Peripartum anemia. Chronic use of corticosteroids. Multiple pregnancy. Polyhydramnios. Domicile outside the city of Campo Grande. Mullerian anomalies. Placenta previa. Chronic inflammatory disease. Chorioamnionitis. Fever of any nature. Infection in the topography of the incision. Myoma at the hysterotomy site. Uterine incision in the body segment. More than 2 extra stitches for hemostasis. Endometritis. Uterine resuturing in the postpartum. Use of corticosteroids up to 30 days postpartum	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-9gqtzng	Assessment of vascular permeability with Point-of-Care ultrasound: an experimental study	Not yet recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8710	Assessment of peripheral venous catheter patency using Point-of-Care Ultrasound (POCUS)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; of both sexes; using peripheral intravenous devices.	Patients with peripheral intravenous devices for surgical reasons, as it is not possible to assess adequate device patency. Patients with vasculitis, as they may present changes characteristic of the pathology, preventing adequate visualization of the venous network.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-8bmtw44	Assessment of weight and height and enuresis after maxillary expansion in mouth breathing children	Recruiting	Intervention	2023-08-01	<NULL>	<NULL>	6301	Evaluation of masticatory function, morphofunctional changes, guarantee and quality of life related to oral health in mouth breathing children after mouth expansion maxilla  Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-30	Programa De Pós Graduação da Faculdade de Odontologia da Universidade Federal do Pará	Programa De Pós Graduação da Faculdade de Odontologia da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-8bmtw44	<NULL>	Children from 8 to 12 years old; Mouth breathers  who present unilateral or bilateral posterior crossbite or maxillary atresia requiring maxillary expansion; Have primary enuresis	Children with psychiatric disorders; Carriers of some Syndromes with cleft lip or and lip and palate; Patients with behavioral disorders and who make use of continuous antieuretic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-3jtxjs	Assessment pityriasis versicolor´s treatmenmt comparing Ketoconazol 2 % cream with Benzoyl Peroxide cream 5% isolateds and with these two together in cream	Recruiting	Intervention	2015-09-27	<NULL>	<NULL>	1107	Randomized double blind clinical trial to compare Ketoconazol 2 % with Benzoyl Peroxide 5% isolatedly and one of  them isolatedly with both together in Pityriasis Versicolor treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal de Pernambuco	Tárcio dos Santos Pereira	https://ensaiosclinicos.gov.br/rg/RBR-3jtxjs	<NULL>	Voluntary, mael or femael; age 18 years old or more who has clinical  of pityriasis versicolor and agree to take part in the study by consent information term	Patients who referring positive HI;, diabetic; pregnant; patient who taken immunossupressor&apos;s drugs; patients with allergic history to any drugs of the study; patients that have antimycotic in the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-2cnzk7	Assessment the Effect of Combined Treatment of diuretic 1.5mg/angiotensin receptor antagonists 50mg and diuretic 1.5mg/angiotensin receptor antagonists 100mg, Compared With 1.5 mg diuretic Monotherapy in the Treatment of Hypertension	Not yet recruiting	Intervention	2015-04-07	<NULL>	<NULL>	441	"Randomized, phase III, multicenter, double-blind, double-dummy trial to assess the effect of combined treatment of Indapamide 1.5mg / Losartan 50 mg and 
Indapamide 1.5mg / Losartan 100mg, compared to monotherapy Indapamide 
1.5 mg in the treatment of essential hypertension"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-12-20	Hospital do Coração/Associação do Sanatorio Sírio	Dr. Celso Amodeo	https://ensaiosclinicos.gov.br/rg/RBR-2cnzk7	<NULL>	"Patients of both sexes, aged &lt;18 years; Patients with systemic hypertension (defined by medical researcher) alone (not by thiazide diuretic) and have at least two blood pressure measurements &lt;140/90, in sitting position, with 5 minutes interval; Patients with laboratory test results, in a period of up to 6 months before, within normal values ??(chemistry, hematology and urinalysis) or that the researcher considers them not clinically significant;
Patient who is willing to continue treatment for hypertension with medications the study. In this case, the patient will be randomized to drug or the combined use of thiazide diuretic, which would be internationally recommended drug for treating essential hypertension. If the patient is using other drug class, to include it in the study and perform the exchange of medication thiazide diuretic, it will be getting the best treatment available and recommended by national and international guidelines for its pathology."	Patients with blood pressure , 180/100 mmHg;Presence of concomitant coronary artery disease, congestive heart failure, diabetes and renal failure (creatinine&gt; 1.5 mg / dL);Patients with hypo or hyperkalemia (serum potassium outside normal range); Patients with alanine aminotransferase greater than 2.5 the upper limit of normal or active liver disease; Pregnant women, or women in childbearing age who are not in use effective contraception or intending to become pregnant during the study period; Patients on drug or alcohol abuse in the last two years; Patients with secondary hypertension (renovascular disease, pheochromocytoma, Cushing&apos;s syndrome); Patients with allergic reactions or hypersensitivity to ACE inhibitors, diuretics or medications containing sulfa and / or any excipients of formulation; Refusal or inability to provide the Informed Consent Term.; Refusal to discontinue the anti-hypertensive medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-3cq8336	Assisted, hybrid, intensive voice treatment for voice disorders related to aging	Recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8740	Assisted, hybrid, intensive voice treatment in elderly people with Presbyphonia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-06	Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Elderly women or men (aged 60 or older) who have been diagnosed with presbyphonia	Structural changes or laryngeal lesions unrelated to aging; diagnosis of head and neck cancer or neurological diseases; smoking or being smoke-free for less than five years; previous laryngeal surgery; previous speech therapy in the last two years	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-7cnj5g	Association between Aerobic Capacity and Sleep in Elderly	Data analysis completed	Intervention	2016-06-16	<NULL>	<NULL>	1431	Association between Cardiorespiratory fitness and Sleep in Elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal da Paraíba	Pulmonar Diagnóstico	https://ensaiosclinicos.gov.br/rg/RBR-7cnj5g	<NULL>	Aged 60 years or older; Men and women; body mass index (BMI) between 18.5 and 29.9 kg / m²; Diagnosed with hypertension; No use of beta-blockers; Considered irregularly active (IPAQ adapted for the elderly).	Smokers / recent ex-smokers (&lt;6 months); Diabetes mellitus; restrictive respiratory diseases / obstructive and / or cardiovascular	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-5h33pjp	Association between brain and heart pressure	Recruiting	Observational	2024-03-19	<NULL>	<NULL>	6872	Association between Intracranial Pressure Compliance and parameters of central and peripheral arterial pressure and hemodynamics	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-11	Faculdade de Medicina da Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5h33pjp	<NULL>	Subjects will be over 18 years of age; pre-hypertensive (arterial pressure sistolic between 130 and 139 mmHg and/or arterial pressure diastolic between 85 and 89 mmHg) or hypertensive (arterial pressure sistolic higher than 140 mmHg and/or arterial pressure diastolic lower than 90 mmHg) according to office blood pressure measurement	Patients taking blood pressure medication; with stage 3 hypertension (arterial pressure sistolic higher than 180 mmHg and/or arterial pressure diastolic higher than 110 mmHg); pregnant or puerperal women; patients diagnosed with intracranial hypertension; patients with hydrocephalus, previous cardiovascular disease which will be defined as: history of coronary heart disease (angina, previous heart attact), diagnosis of Heart Failure, history of valvular heart disease, diagnosis of cardiac arrhythmias, obstructive peripheral arterial disease, aortic aneurysm, previous stroke and advanced chronic liver disease (Child B and C)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-8xh2j23	Association between delta anion gap/delta bicarbonate and patient outcome in surgical patients admitted to intensive care	Data analysis completed	Observational	2023-08-28	<NULL>	<NULL>	6393	Evaluation of the delta anion gap / delta bicarbonate correlation in the outcome in the ICU of patients undergoing major surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2012-09-03	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HC- FMUSP	Hospital do servidor Público Estadual de São Paulo - HSPE/IAMSPE	https://ensaiosclinicos.gov.br/rg/RBR-8xh2j23	<NULL>	Surgical patients (age ≥ 18 years) admitted to the ICU consecutively during the study period and at least one of the following criteria: severe cardiorespiratory disease (presence of coronary artery disease, aortic surgery, chronic obstructive pulmonary disease, or stroke); cancer surgery with extensive resection (esophagectomy, total gastrectomy, liver resection, pancreatectomy, cystectomy or total colectomy); surgical time greater than 6 hours; severe polytrauma; Massive intraoperative blood loss (hematocrit &lt; 20%); intraoperative circulatory shock (mean arterial pressure &lt; 60 mmHg) requiring vasopressors; previous nutritional disorder; body mass index &lt; 20; patients over 65 years of age with evidence of physiological limitation in at least one vital organ	"Patients who stayed less than 24 hours in the intensive therapy ; patients with low life expectancy (cancer with no prospect of treatment); patients with liver failure - (child B or C); patients with renal insufficiency (creatinine clearance &lt; 50mL/min or prior hemodialysis); diagnosis of previous diabetes or two blood glucose levels &gt; 126 mg/dL after
perioperative 8-hour fasting"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-87rdwv	Association between facial types, orofacial pain and mastication	Recruiting	Observational	2014-09-01	<NULL>	<NULL>	331	Association between craniofacial morphology, temporomandibular disorders, bite force, masticatory performance and chewing ability	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-87rdwv	<NULL>	Experimental group: volunteers with TMD, established through the application of the RDC / TMD; both genders; aged between 18 and 45 years; complete permanent dentition (optional presence of third molars) and no more than a missing premolar in the quadrant. For the control group the inclusion criteria are the same, except the presence of TMD.	Subjects presenting history of oral and maxillofacial surgery, facial trauma to the jaw, orthodontic treatment in less than two years, bone disease or neuromuscular facial malformations, severe malocclusion (anterior open bite, unilateral or bilateral posterior crossbite), parafunction habits, facial deformities, or pregnant patients were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-87kzkbm	Association between glucose control and exercise capacity in Type 1 Diabetic adolescents	Not yet recruiting	Observational	2023-12-07	<NULL>	<NULL>	6636	Association between glycemic control and cardiorespiratory fitness in Type 1 Diabetic adolescents	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-08	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-87kzkbm	<NULL>	For the Type 1 Diabetes Mellitus (DM1) group: Individuals, female, with a clinical and laboratory diagnosis of DM1; aged between 13 and 17 years; classified as pubertal (from P3M3), according to biological maturation; agreeing to the procedures and signing the Free and Informed Assent Form and the Free and Informed Consent Form. For the control group: individuals without a clinical or laboratory diagnosis of DM1; agreeing to the procedures and signing the Informed Consent Form and the Informed Consent Form; matched by age, biological maturation and level of physical activity with the participants in the DM1 group	For the Type 1 Diabetes Mellitus (DM1) group: presence of complications such as diabetic retinopathy, nephropathy and/or neuropathy; respiratory exchange coefficient lower than 1.1 in the Cardiopulmonary Exercise Test; loss of data related to the variables of the Cardiopulmonary Exercise Test; absence of information or incorrect completion of information on the time of diagnosis of diabetes, laboratory tests, body composition and level of physical activity. For the control group: respiratory exchange coefficient lower than 1.1 in the Exercise Cardiopulmonary Test; loss of data related to the Exercise Cardiopulmonary Test variables	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-6g87mn	Association between knee ligament injury and restricted hip movement	Recruitment completed	Observational	2020-09-09	<NULL>	<NULL>	4231	The association between ACL injury and restricted hip range of motion among athletes	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Santa Casa de Misericórdia de São Paulo	Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6g87mn	<NULL>	Athletes; volunteers; outpatients at sport trauma at Santa Casa de São Paulo	patients previously diagnosed with lower limb fracture; inflammatory disease; femoroacetabular impingement syndrome; hip dysplasia; lower limb dysmetria; histories of previous knee surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-7q63c4	Association between Low Level Laser Therapy and a protocol of Physical Exercises in pacients with knee Osteoarthritis	Data analysis completed	Intervention	2020-02-17	<NULL>	<NULL>	3495	Association between phototherapy and a protocol of Physical Exercises in pacients with knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7q63c4	<NULL>	women aged 55 to 75 years; with knee osteoarthritis grades II or III on the Kellgren and Lawrence scale confirmed by radiological examination; with cognitive ability to understand the study according to the cut-off score of the Mini Mental State Examination; and classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version (IPAQ).	Presence of cardiovascular desease; presence of neurological desease; presence of musculoskeletal disease that makes it impossible to perform the exercise protocol; use of conventional treatment; use of unconventional treatment; use of alternative treatments that may interfere with the results of the study (physical therapy treatment and / or injections of intra-articular corticosteroids or hyaluronic acid during the last 3 months); absolute contraindication for photobiomodulation, such as the presence of neoplasia in the lower limbs region; and individuals who have malnutrition (BMI less than 18.5) or morbid obesity (BMI equal or more than 40).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-8ttw3f	Association between Midazolam and Ketamine compared to Midazolam as sedative in Autistic patients that will be submitted to odontological treatment under general anesthesia	Recruiting	Intervention	2018-09-20	<NULL>	<NULL>	2218	Association between Midazolam and Ketamine as preanesthetic medication in patients with Autistic Spetrum Disorder submitted to odontological treatment under general anesthesia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Hospital Alberto Rassi- HGG	Hospital Alberto Rassi- HGG	https://ensaiosclinicos.gov.br/rg/RBR-8ttw3f	<NULL>	Autistic disorder; dental treatment; general anestesia; physical condition ASA I and II	Lack of consent, cardiac diseases, prediction of difficult airway, renal disease, alergy or previous adverse reaction to medications of the study, impossibility to give the medication completely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-43p8yst	Association between pain and inflammation after orthodontic elastomeric separation treated with Low-Level Laser Therapy and Cold Atmospheric Plasma: a randomized clinical trial	Data analysis completed	Intervention	2026-01-16	<NULL>	<NULL>	8768	Evaluation of pain parameters in orthodontic treatment under Cold Atmospheric Plasma application compared to Low-Level Laser Therapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Centro Universitário da Fundação Herminio Ometto	<NULL>	<NULL>	<NULL>	Participants aged 18 to 25 years; in good general and oral health; with no previous orthodontic treatment; with no history of antibiotic, anti-inflammatory, or analgesic use in the month prior to or during the study; with complete permanent dentition; presenting malocclusions requiring orthodontic treatment; and with mesial and distal contact between the molars	Participants who report previous orthodontic treatment; who use a prosthesis or implant; who present any physical or intellectual condition that prevents subjective pain assessment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-96dpjz	Association between pain, mastication and inflammation during treatment with different orthodontic appliances	Not yet recruiting	Intervention	2020-03-02	<NULL>	<NULL>	3546	Association between pain, mastigatory quality and inflammatory cytoxins in self-related appliances and aesthetic aligners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Aline Medeiros	Aline Medeiros	https://ensaiosclinicos.gov.br/rg/RBR-96dpjz	<NULL>	age range from 12 to 35 years old; need for orthodontic treatment; with dental crowding between 4 and 8 mm in the upper arch; with proper oral hygiene; no caries; both sexes.	symptoms of temporomandibular joint dysfunction; chronic use of anti-inflammatory drugs or antibiotics; with periodontal disease with generalized probing depth of 3 mm at the test sites; with craniofacial anomalies; wearing orthodontic devices that cause discomfort.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-7knywkd	Association between periodontal problems and metabolic conditions – Cross-sectional study	Recruiting	Observational	2025-11-27	<NULL>	<NULL>	8588	Evaluation of the Relationship between Periodontitis and Systemic Metabolic Alterations – A Cross-Sectional Study.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Volunteers of both genders; presence of at least 15 natural teeth excluding third molars and teeth with indication for extraction; diagnosis of generalized periodontitis stage III grade A or B; 30% of teeth with probing depth and clinical attachment level greater than or equal to 5mm	long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and/or use of antimicrobials in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; chronic gastrointestinal diseases; extensive prosthetic rehabilitations; tobacco use currently or in the last 5 years; pregnancy and lactation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-35hy87d	Association between spots on tooth enamel and facial growth pattern	Recruiting	Observational	2026-03-30	<NULL>	<NULL>	9033	Association between Molar-Incisor Hypomineralization (MIH) and facial growth pattern	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-03	Universidade Federal de Minas Gerais - Faculdade de Odontologia UFMG	<NULL>	<NULL>	<NULL>	Orthodontic documentation of patients aged between eight and twenty five years	Patients with craniofacial anomalies or deformities that can be identified in orthodontic records; Patients with cognitive deficits reported by parents in the anamnesis form included in the orthodontic documentation file	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-85693t	Association between the fall of the bladder or uterus and postural balance in elderly women	Recruiting	Observational	2014-05-13	<NULL>	<NULL>	294	Association between genital prolapse and postural balance in elderly women	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Raquel Henriques Jácomo	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-85693t	<NULL>	Women aged over 60 years old  and less than or equal to 80 years old.	Respiratory disorders, surgeries of the spine, abdomen, and pelvic floor central nervous system, brain tumors, neurological disorders, vestibular and limbic, central and peripheral degenerative diseases, trauma, clinical symptoms such as dizziness, tinnitus, hearing loss, ear fullness, postural hypotension, medicines that change the balance, uncontrolled diabetes mellitus, pelvic floor rehabilitation in the last year, visual impairment or patients with corrective lenses that did not follow the last 2 years, bone densitometry showing osteoporosis in past 3 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-8546xnx	Association between tinnitus, jaw joint problems, Bruxism, Migraine, psychological and emotional aspects.	Recruiting	Observational	2022-03-16	<NULL>	<NULL>	5285	Association between Somatosensory Tinnitus, TMJ, Bruxism, Headache and psychosocial aspects.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8546xnx	<NULL>	Individuals of both sexes; aged over 18 years; without distinction of color and race; sexual orientation or social group; literate; complaining of subjective tinnitus for more than 6 months; who seek care at the Temporomandibular Disorder  and Orofacial Pain clinic of Federal University of Paraná or at the Clinical Hospital of the Federal University of Paraná; without a history of hearing loss and who wish to participate in the research voluntarily. Individuals who agree to participate must read and sign the Free and Informed Consent Form.	Pregnant women or women who are breastfeeding; presence of changes in cognitive functions and impairment and communication skills or that showed impairment in understanding the technical questionnaires; presence of odontogenic pain caused by extensive caries or dental fracture; presence of acute facial pain complaint after recent injury; complaint of pulsatile tinnitus; history of acoustic trauma; history of previous ear surgery; diagnosis of multiple sclerosis; diagnosis of Meniere&apos;s disease; condition with systemic conditions such as rheumatoid arthritis; uncontrolled hypothyroidism; diabetes; hypertension; leprosy; previously diagnosed disabling psychological and neurological changes; eardrum perforation; use of medication such as fluoxetine; high dose aspirin; diuretics; nicotine or alcohol abuse also excluded due to the possible ototoxic power of these substances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-2gxd5pf	Association between tools for quantifying oral and systemic health in pediatric intensive care unit patients	Recruitment completed	Observational	2023-12-16	<NULL>	<NULL>	6662	Association between oral and systemic health scores in pediatric intensive care unit patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-06	Faculdade de Odontologia de Bauru - USP	Faculdade de Odontologia de Bauru - USP	https://ensaiosclinicos.gov.br/rg/RBR-2gxd5pf	<NULL>	Patients hospitalized at the study site, from 03 years of age until 01 day before their 18th birthday, evaluated by dentistry in the first 48 hours of hospitalization, and adding 02 to 03 dental evaluations until 06 days after the first dental evaluation.	Hospitalization time less than 6 days after the first dental evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-9djsc7	Association between vestibular rehabilitation treatments for dizziness	Recruiting	Intervention	2016-07-19	<NULL>	<NULL>	930	Vestibular rehabilitation protocols association: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Universidade Federal de Pernambuco	Hospital Agamenon Magalhães	https://ensaiosclinicos.gov.br/rg/RBR-9djsc7	<NULL>	Elderly both genders with vestibular complaints; aged between 60 and 80 years; hospital patients.	Seniors who underwent audiometry and vectoelectronystagmography; Elderly patients with vestibular complaints; seniors who are not embedded in vestibular rehabilitation program; do not have hearing loss and or hearing aids; noncarriers of psychiatric disorders; They do not have physical disabilities; wheelchair; amputees; do not use crutches; participants visual impairment grave; Elderly unable to understand verbal commands; elderly diagnosed with benign paroxysmal vertigo;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-94dhdy	Association of a Phosphorus Counting Table with Sevelamer for control of blood level of phosphorus in hemodialysis patients	Data analysis completed	Intervention	2018-05-31	<NULL>	<NULL>	1864	Association of a Phosphorus Counting Table with Sevelamer Hydrochloride for control of hyperphosphatemia in hemodialysis patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-03	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94dhdy	<NULL>	Patients on hemodialysis for at least 6 months and who underwent a dialysis regimen at three times a week with a duration of four hours per session; age range greater than or equal to 18 years; literate or had literate carer; phosphate binder use for at least 12 weeks; parathyroid hormone less than 800pg/mL; signed the written informed consent form	Patients who missed more than one hemodialysis session per month; patients in use of anti-inflammatory hormones; patients with neoplasias or active infectious diseases; patients with indication of use of calcium carbonate as phosphate binder and who had no indication of sevelamer hydrochloride use; hypophosphatemic patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-3pxmycv	Association of an Aerobic Exercise protocol with Systemic Photobiomodulation ) for treatment of women with Fibromyalgia	Not yet recruiting	Intervention	2023-12-19	<NULL>	<NULL>	6665	Effects of the association of an Aerobic Exercise protocol with Systemic Photobiomodulation (transcutaneous ILIB) on the level of pain, fatigue and quality of life in women with Fibromyalgia: a single blind randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-05	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-3pxmycv	<NULL>	Women; aged between 18 years and 60 years; who have been diagnosed with fibromyalgia (the diagnosis will be made by a patient&apos;s own referring physician and confirmed by a PhD physiotherapist with eight years of experience in the field of rheumatology, taking into consideration the diagnostic criteria for fibromyalgia set forth by the American College of Rheumatology); with cognitive capacity to understand the study according to the Mini Mental State Examination cutoff score; classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version; and interest in participating in the entire experimental protocol	Participants with uncontrolled systemic diseases such as diabetes mellitus and systemic arterial hypertension; neurological and musculoskeletal conditions that could directly interfere with assessments, such as paralysis, significant sensory alterations, advanced joint diseases (such as joint replacements or osteoarthritis); absolute contraindication to phototherapy, such as the presence of neoplasia; individuals with malnutrition (Body Mass Index -BMI) less than 18.5 kg/m2) or morbid obesity (Body Mass Index -BMI greater than or equal to 40 kg/m2)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5x9ry6s	Association of botox with microsurgery of the nasal septum depressor muscle in the treatment of gingival smile.	Data analysis completed	Intervention	2022-01-26	<NULL>	<NULL>	5172	The influence of microsurgery of the nasal septum depressor muscle associated with botulinum toxin in the treatment of gingival smile.	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-01-30	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-5x9ry6s	<NULL>	Gummy smile above 2mm	Gingival exposure excess (skeletal); use of antibiotics and muscle relaxant: pregnancy and pregnancy; under 18	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-5dnmsk	Association of compounds as an alternative for the treatment of tooht with hypersensitivity	Recruiting	Intervention	2016-09-08	<NULL>	<NULL>	987	Association of monomers as an alternative for the treatment of dentin hypersensitivity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal de Santa Maria- UFSM	Universidade Federal de Santa Maria- UFSM	https://ensaiosclinicos.gov.br/rg/RBR-5dnmsk	<NULL>	Individuals healthy ; both genders; aged between 18 and 80 years; with clinical symptoms dentin hypersensitivity two permanent; teeth in different quadrants; with exposed cemento-enamel junction; without cavitation at the clinical examination	Tooht with carious lesions; defective restorations; erosion; post-operative sensitivity after periodontal treatment or bleaching; bruxism; pulpitis; root fracture; or other conditions that may cause or predispose to the development of dentin hypersensitivity; individuals with special; needs or cognitive impairment compromising data collection; minors (&lt;18y); pregnants; individuals undergoing treatment for dentin hypersensitivity in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-2c825y	Association of genetic differences in the inflammation of patients with traumatized teeth	Recruitment completed	Intervention	2018-08-31	<NULL>	<NULL>	2160	Association of host&apos;s gene polymorphisms that participate in the immune-inflammatory response of traumatized teeth	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2c825y	<NULL>	Patients of both genders. Teeth avulsed and replanted	Immunocompromised patients.  Patients taking continuous medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-2brcxq	Association of Infection with Parenteral Nutrition	Data analysis completed	Observational	2018-09-12	<NULL>	<NULL>	2191	Infection associated with Parenteral Nutrition: Retrospective cohort study in tertiary hospital and systematic review with meta-analysis on the association of Parenteral Nutrition with infections and mortality	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Programa Pós-Graduação em Endocrinologia da Universidade Federal do Rio Grande do Sul	Programa Pós-Graduação em Endocrinologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2brcxq	<NULL>	Adult patients submitted to NP admitted to the Hospital de Clínicas de Porto Alegre (HCPA).	"Central peripheral insertion catheter.
Central catheter for long stay.
Sustained parenteral nutrition less than 72 h after onset."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-76vccv	Association of Laser and Microneedling in Female Baldness.	Not yet recruiting	Intervention	2018-12-20	<NULL>	<NULL>	2402	Association Fotobiomodulation and Microagulhamento Hair Loss in Female Pattern (FPHL): clinical study, randomized, double-blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-76vccv	<NULL>	This study will be conducted in women; aged between 18 and 60 years; who present the female capillary fall; telogen effluvium profile; and androgenetic alopecia; Women with capillary rarefaction; Great hair loss in the last five years; gradually in the last year; they are able to perform no chemical procedure for the period of 3 months.	Scalp scarring; wear wigs; use appliqués that cause weight on the stem; use drugs continuously as anti-inflammatories; anxiolytics; antifungals; hormonal inhibitors; Have fungal or inflammatory conditions; women undergoing hormonal gynecological treatment; Uncontrolled chronic diseases such as Arterial Hypertension; diabetes; Participants unable to understand and sign the TCLE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-57pdy8	Association of Lipid Concentration in the Blood Cells with Clinical Status of Pediatric and Adolescent Patients with Cystic Fibrosis Supplemented with Fish Oil	Recruitment completed	Intervention	2013-05-06	<NULL>	<NULL>	192	Association of Fatty Acid in Erythrocytes with the Clinical Status of Pediatric and Adolescent Patients with Cystic Fibrosis Supplemented with Oil Rich in Omega-3	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-06	Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira	Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-57pdy8	<NULL>	Patients with cystic fibrosis, between 5 and 19 years of age, attended the National Institute of Women&apos;s Health Child and Teenagers Fernandes Figueira.	Patients with liver disease, steatorrhea, diarrhea and vomiting uncontrolled, exacerbation of the disease, indicating lung transplant, pregnant teens, and patients without adherence to medication and nutrition treatment, patients using supplements with omega-3 within 3 months before the study began.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-3yrqfq	Association of malaria during pregnancy with problems in the development of the fetus in the Brazilian Amazon	Recruitment completed	Observational	2016-04-28	<NULL>	<NULL>	820	Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-12-05	Instituto de Ciências Biomédicas - USP	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-3yrqfq	<NULL>	Pregnant women; minimum age of 13 years; all parity; any gestational age; who present or not infections by Plasmodium sp. in their gestation period.	Pregnant women smokers; hypertension; diabetes; who had preeclampsia or eclampsia; show hemorrhage due to other diseases; multiple pregnancy; HIV infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-4n73hw	Association of massage and surface heat treatment on tension-type headache	Recruitment completed	Intervention	2016-11-18	<NULL>	<NULL>	1069	Investigation of association of Manual Therapy and surface heat treatment on Tension-Type Headache	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdades Integradas Einstein de Limeira	Faculdades Integradas Einstein de Limeira	https://ensaiosclinicos.gov.br/rg/RBR-4n73hw	<NULL>	subjects with muscular origin of headaches (tension-type headache); existence of myofascial trigger points.	Subjects with migraine diagnosis; face trauma; systemic rheumatological and oncological diseases; sinusitis; rhinitis; as well as patients in orthodontic treatment; illiterate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-3n32q2k	Association of Periodontitis and Non-Alcoholic Fatty Liver Disease	Recruiting	Intervention	2024-06-11	<NULL>	<NULL>	7061	Association of Periodontitis with the inflammatory state and clinical profile of patients with Non-Alcoholic Fatty Liver Disease	<NULL>	n/a, n/a, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-04	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3n32q2k	<NULL>	Patients from the Hepatology Service of the Clementino Fraga Filho University Hospital diagnosed with non-alcoholic fatty liver disease; both gender	Totally edentulous patients; patients with less than 10 teeth present; smoking patients; patients who have used antibiotic medication in the last six months at baseline, anti-inflammatories or medications potentially inducing gingival hyperplasia (phenytoin, nifedipine and cyclosporine) in the last three months; patients with indication of antibiotic prophylaxis for periodontal clinical approaches; patients undergoing periodontal treatment in the last six months; patients undergoing orthodontic treatment; and patients with any syndrome, except metabolic syndrome; patients who have already used medication that induces hepatic steatosis (e.g. amiodarone, tamoxifen and methotrexate); third molars, residual roots, teeth with non-carious cervical lesion, caries lesion or subgingival restoration, teeth with altered development associated with protective and/or supporting periodontal tissues, teeth involved in local pathological processes, teeth with suspected fracture, teeth with previous or current history of endodontic accident/complication, or even endoperiodontal injury, will not be considered in the periodontal evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-8g9dbc	Association of the elastic bandage to Manual Therapy in the neck pain	Data analysis completed	Intervention	2015-06-01	<NULL>	<NULL>	496	Association of the Kinesio Taping to Manual Therapy in the neck pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-24	Faculdade Integral Diferencial	Multifisio Clínica de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-8g9dbc	<NULL>	Target sample of 10 volunteers of both genders who sought physiotherapy service complaining of neck pain and age between 21 and 30 years	Historic injury in cervical whiplash; diagnosis of pathologies associated like neoplasia and thrombosis; presence of open wounds; allergies to bandage; use of drugs a week before the study or during its accomplishment and that are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-8k4f68	Association of the level of mobility of adult patients in the ICU with the successful removal of mechanical ventilation: protocol for an observational study	Other	Observational	2020-04-30	<NULL>	<NULL>	3793	Association of the mobility level of critically ill patients with the successful withdrawal of mechanical ventilation	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-20	Universiidade Federal de São paulo	Universiidade Federal de São paulo	https://ensaiosclinicos.gov.br/rg/RBR-8k4f68	<NULL>	age 18 to 90 years; admitted to the intensive care unit; under invasive mechanical ventilation for 24 hours or more; with mobility preserved prior to hospitalization.	Neurological disease; neuromuscular disease; degenerative muscle disease; brain or spinal cord trauma; inability to communicate in Portuguese; severe cognitive impairment prior to admission to the ICU; unstable fractures; burns; injury requiring rest prescription; palliative care; amputation of lower members.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-7zs8b5	Association of transcranial direct current stimulation and neurofeedback in memory and cerebral arterial flow in university students	Recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4051	Association of transcranial direct current stimulation and neurofeedback in declarative memory and cerebral arterial flow in young university students - randomized, double-blind, placebo-controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Faculdade São Leopoldo Mandic	UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-7zs8b5	<NULL>	Healthy volunteers; both genders; age between 18 to 30 years	volunteers who have a metallic implant in the head region; have a history of epilepsy or seizures; having psychiatric disorders; history of neurological trauma; making use of centrally acting medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-82p87rq	Association of weakness and low muscle mass with clinical outcomes in hemodialysis patients: SARC-HD project	Recruitment completed	Observational	2024-02-07	<NULL>	<NULL>	6774	Sarcopenia and its association with clinical outcomes in Hemodialysis patients: SARC-HD project	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-01	Centro Universitário ICESP	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-82p87rq	<NULL>	equal or older than 18 years; hemodialysis treatment for at least three months.	Inability or refusal to sign/provide the informed consent form; Any impairment that compromises participation in the study, such as cognitive impairment, locomotor and/or neurological disorders; Change of renal replacement therapy or clinical center (non-partner) during the data collection phase, in a previously planned way, or during the follow-up; Medical contraindication for carrying out the battery of physical tests; Permanent pacemaker (contraindication to bioimpedance measurement); Uncontrolled heart disease, cardiovascular surgery, or recent hospitalization (one month before baseline).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-2ss28r	Associations Among Bed Bath, Sleep and Body Temperature in Intensive Care Patients	Not yet recruiting	Observational	2018-06-20	<NULL>	<NULL>	1918	Associations among Bed Bath, sleep characteristics and body temperature in the critically ill: A cross-sectional study with the Bispectral Index®	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Hospital de Clínicas da Universidade Federal do Paraná	Instituto de Tecnologia para o Desenvolvimento - Lactec	https://ensaiosclinicos.gov.br/rg/RBR-2ss28r	<NULL>	Adult and elderly critically ill individuals; admitted at the intensive care unit 2 of the Hospital de Clínicas da Universidade Federal do Paraná; with mild and moderate gravity diseases; with perspective of spending the next night at that unit; and that are able to understand and accept the terms of the Informed Consent.	Individuals with severe organ disfunction; wich compromise the comprehension and acceptance of the terms of the Informed Consent; individual who don&apos;t accept these terms; those identified as delirious; those who decide to leave the study after the inclusion. Individuals may decline participation at any time independently of justification.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-2s7ptv	Associaton of products for tooth sensitivity treatment	Recruitment completed	Intervention	2016-10-04	<NULL>	<NULL>	1028	Analysis of products association for dentin hypersensitivity treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Faculdade de Odontologia da Universidade Federal de Uberlândia - FOUFU	Faculdade de Odontologia da Universidade Federal de Uberlândia - FOUFU	https://ensaiosclinicos.gov.br/rg/RBR-2s7ptv	<NULL>	Healthy volunteers; both genres; presence of dentin exposure lesions with clinical diagnosis of moderate or severe tooth sensitivity; good oral hygiene	Presence of cavities, cracks or enamel fractures; extensive  or unsatisfactory restorations; recent restorations involving the labial surface; dentures or orthodontics; presence of periodontal disease and/or parafunctional habits; systemic disease and / or severe psychological; constant use of analgesic and / or anti-inflammatory or allergic response to dental products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3sj38mq	Asthma attacks: a study on the origin and prevention in Brazil	Recruitment completed	Intervention	2022-08-23	<NULL>	<NULL>	5575	Asthma attacks: a study of causality and prevention in Brazil	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-08	Associacao ProAR	Secretaria Municipal de Saúde de Salvador	https://ensaiosclinicos.gov.br/rg/RBR-3sj38mq	<NULL>	Age 18 years, without distinction of sex;  Emergency unit care due to severe asthma attacks; Residing in the Railway District and being linked to a Family Health Unit District; Diagnosis of asthma by physician.	"Pregnancy or lactation; Patients with impaired comprehension and verbal communication; Participating or having participated in a clinical trial 6 months prior to the visit; Diagnosis of comorbidities that hamper assessment of asthma: other respiratory diseases, history of
cerebrovascular accident (CVA), neurological disease, congestive heart failure (CHF), myopathies,
psychiatric diseases and advanced neoplasia; History of smoking greater than or equal to 10 packets per year; Be regularly monitored at an asthma health service; Do not have a landline or mobile phone."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-5x4dc9	Asthma control evaluation with inhaled  corticosteroid spray aided by non valved homemade spacer.	Data analysis completed	Intervention	2015-07-28	<NULL>	<NULL>	564	Asthma control evaluation with inhaled  corticosteroid spray aided by non valved homemade spacer.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-07-26	Pós Graduação em Ciências da Saúde da Universidade Federal de Pernambuco	Pós Graduação em Ciências da Saúde da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5x4dc9	<NULL>	180 Volunteers with asthma poorly or partially controlled as defined by GINA (Global Initiative for Asthma); aged between 18 and 65; who had inhaled corticosteroid prescription for daily use by the attending physician.	Patients unable to use the inhaled drug due to motors or mental problems; with other lung diseases diagnosed or reported; who can not perform spirometry, unable to properly use the homemade or commercial spacers after watching educational film three times; patients who refuse to participate and sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-63f8mpz	Asymmetric Radioelectric Converter - REAC protocols in conditions of sleep disorders	Terminated	Intervention	2024-06-18	<NULL>	<NULL>	7073	Asymmetric Radioelectric Converter Protocols - REAC in disturbance conditions of Sleep	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal do Amapá - UNIFAP	Universidade Federal do Amapá - UNIFAP	https://ensaiosclinicos.gov.br/rg/RBR-63f8mpz	<NULL>	Individuals with self-perceived poor sleep quality; age range of 18 to 60 years; both sexes	Participants with severe psychiatric disorders or cognitive impairment; participants using a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-6jkg8s	At-home bleaching using prefilled whitening trays compared with fabricated trays	Data analysis completed	Intervention	2018-04-13	<NULL>	<NULL>	4628	At-home bleaching using prefilled whitening trays compared with fabricated trays: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista &quot;Julio de Mesquita Filho&quot;	"Instituto de Ciência e Tecnologia, Universidade Estadual Paulista ""Julio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-6jkg8s	<NULL>	Ages from 18 until 30 years old; good general health; do not present enamel erosion, dental abfraction, caries, periodontal disease or fluorosis ; do not use orthodontic appliance or removable prostheses; present all teeth - first molar to first molar (Upper and Lower); Avaiability of recurring returns; absence of gingival recession; teeth with A2 or darker color.	Chemically dependent patients, nonsmokers and alcoholic ; medical condition that may interefere in patients&apos; security during the study: use of drug therapy to chronic disease or allergic reaction to substances that will be used; pregnancy; participate of another study in the same time; pressenting restorations in the six anterior teeth of each arch; frequent use of fluoride supplementation or desensitization substances; bruxism; periapical lesions; tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-58gw8gg	At-home Bleaching with 5% versus 10% Carbamide Peroxide: a randomized, split-mouth, triple-blind, non-inferiority controlled trial	Not yet recruiting	Intervention	2025-04-17	<NULL>	<NULL>	7939	Comparison of bleaching efficacy of 5% vs. 10% Carbamide Peroxide: a randomized, split-mouth, triple-blind, non-inferiority controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-58gw8gg	<NULL>	Patients must be 18 years or older. Both sexes. Being in good general and oral health. With no carious lesions, restorations, or endodontic treatment in the maxillary anterior teeth. The maxillary canines must have a shade of A2 or darker according to the value-oriented Vita Classical shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Patients already undergoing tooth whitening; undergoing orthodontic treatment; with severe discoloration due to tetracycline stains and fluorosis; participants with any other pathology that could cause sensitivity (such as recession, exposed dentin or presence of visible fissures in the teeth) or history of hypersensitivity;  pregnant and lactating women; patients with dental bruxism; taking analgesics or anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-283byt	At-home bleaching with WhiteClass 10%, applied on the palatal face, is effective	Data analysis completed	Intervention	2020-02-19	<NULL>	<NULL>	3503	Effectiveness of at-home bleaching with 10% Hydrogen Peroxide applied on the palatal face. Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-18	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-283byt	<NULL>	Volunteers between 18 and 40 years old; no systemic diseases; without caries; no periodontal diseases; having at least two central incisors or canines with a color C2 or darker; with the six upper anterior teeth free of restorations on the palatal and buccal surfaces; sound enamel; without pathological, physiological and drug alterations	Volunteers with orthodontic braces; severe crowding; presence of intrinsic spots; taking anti-inflammatory drugs; smoker; alcoholist; pregnant women; lactating women; patients who report severe sensitivity during treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-5v3sspr	Atherothrombotic aspects of cerebrovascular disease	Recruitment completed	Observational	2023-07-30	<NULL>	<NULL>	6288	Atherothrombotic profile of cerebrovascular disease: prospective cohort	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-31	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5v3sspr	<NULL>	Volunteers with asymptomatic or symptomatic extracranial carotid stenosis, both genders, minimum age of 18 years.	Restenosis after previous treatment of carotid endarterectomy or carotid angioplasty in the artery of interest; Inability to sign an informed consent form; Life expectancy less than 6 months; Advanced dementia; Severe kidney failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-359p69v	AtivaRS project: Exercise Practice to reduce Sedentary Behavior in the population	Not yet recruiting	Intervention	2023-08-21	<NULL>	<NULL>	6552	AtivaRS project: Combating Sedentary Lifestyle	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade do Vale dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-359p69v	<NULL>	Sedentary individuals; aged between 20 and 60 years; with no medical contraindications for physical exercise; must own a smartphone; agree to participate in the research by signing the informed consent form	Individuals who experience angina during exertion; history of acute myocardial infarction within the 12 months prior to the start of the protocol; require oxygen supplementation; exhibit clinical instability in the month preceding the protocol initiation; uncontrolled hypertension; visual diseases that prevent the performance of the protocol; chronic conditions  hindering participation in the exercise protocol; illiterate; refuse to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-6nz2cg	Attention effects on handicap person&apos;s movement	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	87	The effects of attention directed to movement parameters on motor behavior of handicap persons	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-08	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6nz2cg	<NULL>	"Healthy adults:  history of no muscular injury or not healed on dominant upper limb; no geometrical alterations on dominant upper limb; no reduction on normal joint amplitude of dominant upper limb; do not be overweight or obese.

Handicap adults: to have a minimum of 1yr of medular injury; Level A or B of American Spinal Injury Association (ASIA); realese from physical therapy treatment for a maximum of 2yr; trunk balance sufficient to sustain upper limbs at 90 degrees angle for at least 30sec.; do not have history of muscular injury or not healed on dominant upper limb; do not have geometrical alterations on dominant upper limb; do not have reduction on normal joint amplitude of dominant upper limb; ulcera pressure; urinary infections; depression; do not be overweight or obese."	"Healthy adults:  to have history of muscular injury or not healed on dominant upper limb; geometrical alterations on dominant upper limb; reduction on normal joint amplitude of dominant upper limb; overweight or obesity.

Handicap adults: to have more than 1yr of medular injury; Level C or higher of American Spinal Injury Association (ASIA); realese from physical therapy treatment for more than 2yr; trunk balance insufficient to sustain upper limbs at 90 degrees angle for at least 30sec.; have history of muscular injury not healed or treated on dominant upper limb; geometrical alterations on dominant upper limb; reduction on normal joint amplitude of dominant upper limb; ulcera pressure; urinary infections; depression; overweight or obesity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-92dbtx	Attention to the health of the elderly in primary health care	Data analysis completed	Intervention	2018-07-05	<NULL>	<NULL>	1961	Attention to the health of the elderly: a proposal for multidimensional evaluation and intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-92dbtx	<NULL>	Age greater than or equal to 60 years; male or female gender; be enrolled in the Primary Health Care of your municipality; and present preserved cognitive status.	Major physical disability; cognitive impairment; residence time in your municipality less than six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-6vmmhfp	Attention training to improve school performance in autism	Data analysis completed	Intervention	2021-06-09	<NULL>	<NULL>	4740	"Evaluation of a Computerized Attention Training program to improve
academic performance in children with Autism Spectrum Disorder"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Centro de Atenção Integrada à Saúde Mental (CAISM) da Santa Casa de São Paulo	Universidade Presbiteriana Mackenzie	https://ensaiosclinicos.gov.br/rg/RBR-6vmmhfp	<NULL>	A diagnosis of Autism Spectrum Disorder; between 8 and 14 years old; both genders; patients from the reference unit for autism from Santa Casa of São Paulo; no severe behavioral problems	Severe behavior problems that make data collection unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-8sg9x52	Attention, memory and quality of life in post COVID-19 adults	Recruiting	Intervention	2025-06-16	<NULL>	<NULL>	8056	Attention, memory, self-reflection and insight, and quality of life in post COVID-19 adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-02	Programa de Pós-graduação em Psicologia da Universidade Federal do Espírito Santo - Campus Goiabeiras	Instituto de Ensino e Pesquisa Alberto Santos Dumont	https://ensaiosclinicos.gov.br/rg/RBR-8sg9x52	<NULL>	healthy volunteers; volunteers with cognitive impairment associated with post-COVID syndrome; both genders; aged over 18 and under 60 years; not using psychoactive substances that affect memory, such as benzodiazepines and hypnotics; no history of neurological and/or psychiatric disorders before or after COVID-19; provide authorization to participate in the study by signing the Informed Consent Form	be under 18 years old and over 60 years old; use psychoactive substances that affect attention and memory; present physical or cognitive repercussions resulting from other diagnoses prior to or subsequent to COVID-19; present a history of attention and memory impairment prior to the diagnosis of COVID-19	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-7gw2794	Auditory and visual stimuli test proposal for tinnitus patients evaluation	Not yet recruiting	Observational	2022-01-25	<NULL>	<NULL>	5167	An auditory-visual Stroop test proposal for tinnitus patients evaluation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-20	Universidade Federal de São Paulo (UNIFESP-EPM)	Universidade Federal de São Paulo (UNIFESP-EPM)	https://ensaiosclinicos.gov.br/rg/RBR-7gw2794	<NULL>	As inclusion criteria, will be selected, individuals aged between 18 and 59 years old, with tinnitus and hearing thresholds within normal limits for pure tone audiometry or hearing loss at high frequencies (above 3kHz). Such subjects must have performed acuphenometry in a previous audiological evaluation and must present constant subjective tinnitus, of the whistle or wheezing type, uni or bilateral. The Control Group will comprise individuals without tinnitus, aged between 18 and 59 years, pure tone audiometry within normal limits or with hearing loss at high frequencies (from 3kHz), with no history of neurological and/or psychiatric alterations.	Individuals with pulsatile tinnitus, psychiatric or neurological diseases diagnosed up to the time of test execution will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4jvyfh3	Auditory and visual therapy for children with comprehension difficulties	Recruiting	Intervention	2023-08-31	<NULL>	<NULL>	6402	Effect of auditory and visual Training in children with auditory processing Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4jvyfh3	<NULL>	Submit a signed term of consent and assent; Individuals aged 7 and 10, male and female; Audiometric thresholds within normal ranges at the time of assessment; Type A tympanometric curve and presence of ipsi and contralateral acoustic reflexes; Scale of Auditory Behaviors questionnaire with a score of less than 46 points, which indicates a risk situation for Auditory Processing Disorder; Diagnosis of Central Auditory Processing Disorder, carried out by the researchers, characterized by alteration in at least two of the behavioral assessment tests of Central Auditory Processing; Show alteration in the evaluation of Auditory Processing and visual perception; Not present neurological alterations, genetic syndromes or other pertinent conditions that could influence the evaluations; Present receptive and expressive language necessary to understand the commands necessary to perform the tests	Not being able to complete the battery of tests due to lack of understanding of them; Present neurological alterations, genetic syndromes or other pertinent conditions that may influence the evaluations; Not being available to attend intervention sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-5cgpv4t	Auditory Brainstem Response (ABR)) hearing test in children with speech delay: comparison between Inhalation and Intravenous Anesthesia	Not yet recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8123	Auditory Brainstem Response (ABR) in children with language delay: comparison between Inhalation and Intravenous Anesthesia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2026-02-25	Faculdade de Medicina da Universidade de São Paulo	Instituto de Pesquisa e Ensino em Saúde Infantil (PENSI)	https://ensaiosclinicos.gov.br/rg/RBR-5cgpv4t	<NULL>	Children under investigation for language delay or suspected autism spectrum disorder, or undergoing audiological monitoring, who are scheduled to undergo an auditory brainstem response under general anesthesia must present: transient otoacoustic emissions with at least four reproducible responses; distortion product otoacoustic emissions with at least four reproducible responses; and auditory brainstem responses demonstrating waves I, III, and V elicited by a click stimulus at 80 decibels	Suspected or confirmed genetic syndromes; american society of anesthesiologists physical status classification of three or higher; patients with middle ear pathology; non-portuguese speakers; clinical history of neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:09
RBR-6wjnjh	Auditory function assessment in elderly with hearing loss before and after hearing rehabilitation	Recruiting	Intervention	2019-10-14	<NULL>	<NULL>	3081	Auditory function assessment in elderly with presbycusis before and after hearing rehabilitation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	UNESP Universidade Estadual Paulista Julio de Mesquita Filho, Campus de Marília	UNESP Universidade Estadual Paulista Julio de Mesquita Filho, Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-6wjnjh	<NULL>	Age group of 60 years or more; both genres; presence of hearing loss / presbycusis; indication of an otorhinolaryngologist to adapt hearing aids	Presence of alteration of the middle ear and / or hearing loss in the frequencies of 0.50, 1 and 2 kHz and / or thresholds 71 dBNA in the frequencies of 3 to 8 kHz, detected by impedanciometry and pure tone audiometry; positive tracing of cognitive impairment detected by the MoCA - Montreal Cognitive Assessment, in its Portuguese version.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-10yj42dj	Auditory neurostimulation with Brainwave Entrainment and effects on mental health	Recruitment completed	Intervention	2022-10-20	<NULL>	<NULL>	5673	Stimulation of binaural and isochronic tones in Brainwave Entrainment and its effects on the modulation of mood states and emotional well-being	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-18	Universidade Federal de Santa Catarina	Metha Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-10yj42dj	<NULL>	The research subjects will be healthy volunteers of both genders; aged 18 or over; mental illness or chemical dependency; and agreement to sign the TCLE (Free and Informed Consent Term)	Patients who have an evaluation and cut above the acceptable in the DASS-21 (Depression, Anxiety and Stress Scale) and Pittsburgh tests will be excluded from the trial; as well as those with psychosis; schizophrenia; epilepsy or a history of substance abuse; people with hearing problems and a history of therapeutic use of binaural or isochronic sounds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-8wmvbnw	Auditory Processing Assessment in Patients with Type 1 Neurofibromatosis before and after auditory training	Recruitment completed	Intervention	2021-06-11	<NULL>	<NULL>	4744	Behavioral and electrophysiological evaluation of Auditory Processing in patients with Type 1 Neurofibromatosis before and after auditory training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-19	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8wmvbnw	<NULL>	Individuals aged 9 to 35 years old, presenting a medical diagnosis of type 1 neurofibromatosis; present auditory thresholds less than or equal to 15 dBHL between 250 and 4000Hz, bilaterally, characterizing audibility thresholds within the normal range; to present type A tympanometric curves, bilaterally, featuring adequate functioning of the middle ear; present Central Auditory Processing Disorder.	Neurofibromatosis type 1 patients with comorbidities such as Attention Deficit Hyperactivity Disorder, autism and intellectual disability; perform radiotherapy or chemotherapy that compromises peripheral hearing; the presence of epileptic seizures and epilepsy not controlled by a medical team; present alteration of the middle ear; have previously undergone any format of rehabilitation of central auditory processing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-42nwshv	Auditory skills in schoolchildren and their impact on learning	Data analysis completed	Intervention	2025-12-03	<NULL>	<NULL>	8611	Effects of Neuroauditory Stimulation (SENA), Visuomotor Stimulation, and Acoustically Controlled Auditory Training on Central Auditory and Visual Processing in schoolchildren	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade Federal de São Paulo, UNIFESP	<NULL>	<NULL>	<NULL>	Present the signed informed consent and assent forms; Be between 8 years and 11 years and 11 months of age, male or female; Report complaints of learning difficulties; Have hearing thresholds up to 15 dB HL; Show alterations in Auditory Processing and visual perception assessments	Evidence of neuropsychiatric conditions that prevent the performance of the selected procedures; Lack of availability to attend the intervention sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3stmcdm	Auditory training with music in children with difficulties in learning and understanding sounds	Recruiting	Intervention	2024-10-16	<NULL>	<NULL>	7436	Musical auditory training in children with learning difficulties and Central Auditory Processing Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3stmcdm	<NULL>	Be between 8 and 9 years old, have sufficient cognitive and linguistic skills to understand the tasks, Intelligible articulatory production, Audiometric thresholds within normal limits, present changes in at least one test from the minimum battery of the Central Auditory Processing assessment, suggested by the Brazilian Academy of Audiology as a criterion for diagnosing the disorder, present learning difficulties previously identified by the teacher and confirmed through a speech-language pathology assessment of reading and writing at the word level	Having undergone speech therapy, middle ear changes at the time of evaluation, be bilingual, frequently use a musical instrument, present evident or previously diagnosed neurological and emotional changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-7543ns	Auricular acupuncture for post-operative nausea and vomiting.	Recruiting	Intervention	2018-01-09	<NULL>	<NULL>	1560	Influence of Auricular Acupuncture in order to prevent nausea and vomiting after Laparoscopic Cholecystectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Faculda de Ciências Médicas Universidade de Pernambuco	Faculda de Ciências Médicas Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7543ns	<NULL>	adult females between; 18 and 70 years old; with Body Mass Index under 35; who belong to classification 1 and 2 of the American Society of Anaesthesiology; submitted to uncomplicated Laparoscopic cholecystectomy.	Laparoscopic cholecystectomy with surgical or anesthetic complications; operation time longer than 90 minutes; nausea and vomiting on the immediate preoperative time; patient ASA 3 or more; use of antiemetic 12 hours before the procedure; continuous use of analgesic or corticoids; abusive history of alcohol and drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-9tkt8z	Auriculoterapia e Massagem for Neck Pain and  Quality of life improvement	Data analysis completed	Intervention	2017-07-24	<NULL>	<NULL>	1304	Applicability of the Auriculotherapy and Massage to reduce Pain, Stress, Anxiety and Quality of life improvement	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-9tkt8z	<NULL>	Pain score equal or greater than 5 by the Visual Analogue Scale; age between 20 and 55 years	"Paresthesia; decreased strength; anti-inflammatory drugs; analgesics and muscle relaxants; cervical spine surgeries;
inflammation and or infection in treated regions;tissue damage in the external ear or cervical and thoracic region"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-3jvmdn	Auriculotherapy effectiveness for the reduction of musculoskeletal pain, anxiety and stress in healthcare workers	Recruiting	Intervention	2020-07-30	<NULL>	<NULL>	5665	Auriculotherapy effectiveness in reducing health problems among hospital workers	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Tânia Solange Bosi de Souza Magnago	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3jvmdn	<NULL>	Subproject 1: present availability for auriculotherapy sessions; and, having chronic pain in the spine region (cervicalgia, chest pain and/or low back pain) lasting at least 3 months; and with a minimum intensity of 4 on the Numerical Pain Scale. Subproject 2: Nursing professionals, working in the General Surgery Unit – Inpatient Service, in the Operating Room, in the Anesthetic Recovery Room and in the Intermediate Recovery Room; professionals who are working during the data collection period, and who are available to carry out the auriculotherapy sessions. Being anxious (values ≥ 10 are considered positive for the occurrence of anxiety disorder according to the GAD-7 Generalized Anxiety Disorder instrument) and having a medium level of stress (29 to 60 points) according to the List of Signs and Symptoms of Stress	Subproject 1: Being pregnant; present allergy to seeds; having inflammation in the atrium; be undergoing treatment for chronic musculoskeletal pain with alternative therapies and patients diagnosed with renal lithiasis with surgical indication. Subproject 2: Being pregnant; Using psychotropic medication or other therapy for the treatment of mental disorders during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-3xktv5	Auriculotherapy effectiveness in reducing smoking	Recruiting	Intervention	2013-12-09	<NULL>	<NULL>	267	Auriculotherapy effectiveness in reducing smoking	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-07	Universidade Federal de Alfenas	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-3xktv5	<NULL>	"Possessing 18 years of age or older;
Being a smoker (daily make use of any quantity of cigarettes, including a);
Present level of carbon monoxide in exhaled air (COex) above 6 ppm (parts per million).
Having the desire to quit smoking;
Voluntarily participate in the study with available time to commit to sessions of auriculotherapy."	"Infection, inflammation or injury to the ear;
Make use of ear piercing (except earrings normal);
Make some treatment for tobacco, medicinal or not.
Pregnant."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-7gshm23	Auriculotherapy effects in the treatment of nausea and vomiting in pregnant women	Recruiting	Intervention	2021-02-10	<NULL>	<NULL>	4532	Auriculotherapy effects in the treatment of nausea and vomiting in pregnant women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Universidade Federaldo Ceará	Universidade Federaldo Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7gshm23	<NULL>	Among the pregnant womenat 13 weeks or less of gestational age, the ones with complaints of nausea and/or vomiting, that are not in use of antiemetic drugs, that are characterized as low risk pregnancy and have availability for return in 7 days will be assessed.	Use of antiemetics, diagnosed mental disease, speach or hearing difficulties that might make it impossible to fill the questionary or to conduct the interview, dermatologic lesion on auriculotherapy point of treatment and allergy to the intervetion material.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-4cbtxv2	Auriculotherapy for migraine treatment in women, a clinical study	Recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7909	Effect of Auriculotherapy in the treatment of women with Migraine: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-15	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-4cbtxv2	<NULL>	Medical diagnosis of migraine with a minimum duration of one year; women; aged between 18 and 60 years; agreement to participate in the study; formalization of participation through the signing of the Informed Consent Form (ICF)	Women diagnosed with tension headache; other pain syndromes; pregnant women; continuous use of anti-inflammatory drugs; antidepressants; or analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-6rdvyt4	Auriculotherapy for pain in people taking medication	Recruitment completed	Intervention	2025-07-08	<NULL>	<NULL>	8108	Auriculotherapy as an Analgesia strategy for users of chronic pain medications in primary health care	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-13	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6rdvyt4	<NULL>	Women; users of continuous analgesics, anti-inflammatories and opioids; who collect them at the Ijuí Municipal Pharmacy; with a minimum collection frequency of three consecutive months; age between 18 and 60; complete at least 8 Auriculotherapy sessions	Pregnant women; those who are unable to speak, see and hear; medically diagnosed with cognitive deficit; oncological diseases; serious autoimmune diseases; use of immunobiological drugs; who do not accept to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9t97hgt	Auriculotherapy for people affected by flooding in Rio Grande do Sul	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7951	Auriculotherapy in post-natural disaster care in Rio Grande do Sul	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-06	Universidade Federal de Santa Maria	Programa de Pós-Graduação em Enfermagem da Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-9t97hgt	<NULL>	Residents of Bento Gonçalves affected by the natural disaster; who needed to evacuate their place of residence or work; who suffered significant loss of material assets, documented or self-reported; mourning for family, friends or acquaintances as a direct consequence of the disaster; minimum age of 18 years; both sexes	People with a history of known allergy to materials used in the intervention such as micropore, adhesive tape, crystal spheres or seeds; presence of lesion or active inflammation in the ear; current treatment with Auriculotherapy or auricular acupuncture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-106nnmgg	Auriculotherapy for postpartum pain relief – a randomized clinical trial	Not yet recruiting	Intervention	2025-05-07	<NULL>	<NULL>	7990	Efficacy and acceptance of auriculotherapy for pain relief in the immediate postpartum period at the university hospital of Florianópolis - a pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-29	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-106nnmgg	<NULL>	Vaginal delivery or cesarean section performed at Universitary Hospital (HU) of Universidade Federal de Santa Catarina (UFSC); age between 18 and 50 years; live newborn; agreement to participate in the study; sign the informed consent form	Severe medical complications in the postpartum period; history of severe psychiatric disorders or cognitive impairment; presence of piercings or similar items at the acupuncture point sites; contraindications for auricular acupuncture (infections at the application site, known allergies); additional surgeries or procedures (tubal ligation, hysterectomy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-5t96cx6	Auriculotherapy for Sexual Function in Menopausal women	Recruitment completed	Intervention	2025-05-14	<NULL>	<NULL>	8005	Auriculotherapy for Sexual Function in Climacteric women: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5t96cx6	<NULL>	The study will be developed with women between 40 and 65 years old, with a score less than or equal to 23 (which indicates the presence of FSD in women in menopause) in the Female Sexual Functioning Index (FSFI) scores, followed at the aforementioned UAPS Antonina Caeté Pedrosa in Mombaça, Ceará. The following inclusion criteria will be followed for sample selection: women between 40 and 65 years old; presenting cognitive capacity to respond to the variables of interest.	"Exclusion criteria will be: injuries or inflammation in the ear; allergy to micropore tape; pregnant women; presence of mental disorders that compromise the collection of variables of interest.
The criteria for discontinuation: participants who wished to stop their participation at any time during the research; presented reactions considered unpleasant related to the treatment; disagreed with the allocation of seeds in the protocol points; missed two or more sessions for any reason."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-8j8v74	Auriculotherapy for stress and anxiety treatment	Recruitment completed	Intervention	2019-08-19	<NULL>	<NULL>	2880	"Auriculotherapy with silicon tablets and placebo for stress, anxiety and improvement of quality of life:
Randomized clinical trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Instituto Terapia Integrada e Oriental	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-8j8v74	<NULL>	Volunteers with a score on the List of Stress Symptoms of 40 to 120 points corresponding to medium and high stress; Age between 18 and 60 years.	Volunteers who carry out treatment with some complementary practice simultaneously to the data collection; who use controlled-use medications, such as anxiolytics, antidepressants and herbal medicines.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-3bvgwq9	Auriculotherapy for stress and quality of students	Recruitment completed	Intervention	2025-04-30	<NULL>	<NULL>	7975	Effect of Auriculotherapy on quality of life and stress in undergraduate nursing students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-20	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-3bvgwq9	<NULL>	Students with active enrollment in the nursing degree at the Federal University of Espírito Santo; both sexes	Students on leave or with a suspension of enrollment; students who have started some drug treatment other integrative practice in the last 3 months; students pregnant up to 3 months; students with lesions in the pinna, injury or deformity in the ear; use of ear piercing (except for normal earrings); use of bilateral hearing aids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-34tsc8m	Auriculotherapy in improving sleep quality in people living with HIV	Recruiting	Intervention	2022-03-09	<NULL>	<NULL>	5268	Efficacy of auriculotherapy in improving sleep quality in people living with HIV: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-34tsc8m	<NULL>	People living with HIV (PLHIV) aged 18 or over, of both sexes; On antiretroviral therapy (ART) for at least three months, a period stipulated based on the time the patient needs to adapt to the medication. According to the literature, from the first month onwards, initial adverse events are minimized, as in the case of the use of Efavirenz (EFV), which has acute effects on the central nervous system in up to 50% of patients in the first week of treatment, such as : dreams, nightmares, sadness, irritability, nervousness, dizziness and difficulty sleeping (NGUYEN et al., 2011; WATERS et al., 2011; SCOURFIELD et al., 2012; OSHINAIKE et al., 2014; ALLAVENA, 2015). Other antiretroviral drugs can also cause sleep disorders, such as Zidovudine (AZT), Stavudine (d4T), Lamivudine (3TC), Indinavir (Crixivam) (BRASIL, 2004); Complaints of poor sleep quality, confirmed by the Pittsburgh Sleep Quality Index (PSQI-BR), with scores greater than 10 (BUYSSE et al.; 1989; BERTOLAZI et al., 2011; FONSECA et al., 2010; ; KONRAD 2005); Availability for face-to-face return on the 8th and 15th days of the beginning of the intervention, and telephone assessment on the 22nd and 29th days of the intervention; Have your own landline or cell phone.	Patients with disabling mental illness; pregnant women; Homeless people and those deprived of their liberty in penitentiaries; Dermatological lesion at the site of the auriculotherapy points of the study; Allergy to the material used in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-6gpvcvr	Auriculotherapy in labor pain: randomized clinical trial	Recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6396	Effects of auriculotherapy in pain reduction in parturient women: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-25	Centro de Ciências da Saúde - Universidade Federal da Paraíba	Instituto Cândida Vargas	https://ensaiosclinicos.gov.br/rg/RBR-6gpvcvr	<NULL>	Women aged over 18 years; in active labor with spontaneous dilation &gt;4cm, of any parity, with two or more contractions in 10 min; with intact skin in the auricle; whose fetus is alive, in vertex cephalic presentation and with good conditions of vitality; who agree to participate in the research, with subsequent signing of the Informed Consent Form (TCLE); without serious illnesses and/or complications that consider their delivery to be high risk	Women who have too many psychiatric or neurological disorders at the time of the survey; who have a phobia of touch, who are using some integrative therapies in addition to the usual care of the obstetric service; with immediate or close indication of any surgical procedure, except cesarean section after labor; in use of analgesic medication for less than 6 hours of eligibility and admission to the research; in the latent stage of labor, who denies participating in the research and/or does not wish to sign the TCLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-69cyr2	Auriculotherapy in sleep disorders in patients with rheumatoid Arthritis.	Recruitment completed	Intervention	2019-07-04	<NULL>	<NULL>	2796	Invasive auricular acupuncture in sleep disorder in patients with rheumatoid Arthritis: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-69cyr2	<NULL>	Diagnosis of Rheumatoid Arthritis; age greater than or equal to 18 to 100 years; difficulties related to sleep: starting and / or maintaining sleep and also the presence of non-sleepy sleep for at least 1 month.	Cutaneous lesions in the auricular pavilion that prevent the placement of atrial acupuncture points; amputation of the auricular pavilion; previous otoplasty; suspected or confirmed pregnancy; phobia by needles; previous atrial acupuncture; deficits in vision, hearing or cognitive impairment that prevent the proposed evaluations from being performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-38hjyt3	Auriculotherapy in Stress reduction in primary care health professionals	Data analysis completed	Intervention	2021-03-23	<NULL>	<NULL>	6030	Auriculotherapy to reduce occupational stress in primary care health professionals during the COVID-19 pandemic: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade do Estado da Bahia, Departamento de Ciências da Vida	Universidade do Estado da Bahia, Departamento de Ciências da Vida	https://ensaiosclinicos.gov.br/rg/RBR-38hjyt3	<NULL>	Volunteers with a stress level above the cutoff point; both genders; have completed the proposed questionnaires and scales; age between 18 and 70 years.	Participants on vacation or leave during the survey period; pregnant women; medical diagnosis of depression; medical prescription of antidepressants; having undergone auriculotherapy treatment in the last three months; have done some training in auriculotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-5d4xkm	"Auriculotherapy in the adult chemotherapy clinic: a complementary proposal
combined with nursing care to relieve nausea and vomiting"	Data analysis completed	Intervention	2020-11-17	<NULL>	<NULL>	4377	"Auriculotherapy in the adult chemotherapy clinic: a complementary proposal
combined with nursing care to relieve nausea and vomiting"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-27	Universidade Federal Fluminense	Instituto Nacional de Câncer José Alencar Gomes da Silva	https://ensaiosclinicos.gov.br/rg/RBR-5d4xkm	<NULL>	Adult men aged 18 to 59 years diagnosed with cancer, undergoing chemotherapy from the second cycle with protocols with the following drugs with a high degree of emetogenicity: Combination AC (Doxorubicin + Cyclophosphamide), Carboplatin (AUC greater than or equal to 4mg / m²), Cisplatin, Cyclophosphamide (greater than or equal to 1500mg / m²), Dacarbazine, Doxorubicin (greater than or equal to 60mg / m²), Epirubicin (greater than 90mg / m²) and Ifosfamide (greater than or equal to 2g / m²). In addition, patients with previous experience of nausea and vomiting regarding previous chemotherapy and presentation of the KPS (Karnofsky Performance Status) scale above 70%.	Adult men with cognitive deficit described in medical records; with previous gastrointestinal diseases or previous anti-ulcer treatment; cancer located in the stomach, due to the interference of the disease in the control of nausea and vomiting; neoplasms located in the Central Nervous System (CNS), as they can interfere in the center of vomiting; previous history of allergy to antiallergic micropose patch or any other patch currently available; patients who started outpatient chemotherapy but were hospitalized, for some reason, and continued inpatient chemotherapy, as they receive intravenous antiemetic medication every 8 hours and prolonged venous hydration, which could be a bias for the research. And previous history of use of antiemetics that are not standardized by the hospital.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-7zbz3p3	Auriculotherapy in the birth process	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8417	Effects of Auriculotherapy on the birth process: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Estadual de Londrina	Santa Casa de Misericórdia de Cambé	https://ensaiosclinicos.gov.br/rg/RBR-7zbz3p3	<NULL>	Chronological age over 18 years; from 37 weeks; regardless of parity; who are admitted for induction of labor	Pregnant women who are induced using the Krause method	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-2jwy9xf	Auriculotherapy in the treatment of Anxiety in people with HIV	Recruiting	Intervention	2021-10-15	<NULL>	<NULL>	4990	Auriculotherapy in the management of Anxiety symptoms in people living with HIV: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Federal University of Ceara	Federal University of Ceara	https://ensaiosclinicos.gov.br/rg/RBR-2jwy9xf	<NULL>	People living with HIV; 18 years of age or older; and with a score greater than or equal to 35 on the State-Trait Anxiety Inventory.	Pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3rkv2pf	Auriculotherapy in the treatment of cervical pain	Recruitment completed	Observational	2020-12-10	<NULL>	<NULL>	4408	Pilot study on the use of french auriculotherapy in the treatment of cervical pain	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-07-22	Fernando Mendes Sant&apos;Anna	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3rkv2pf	<NULL>	Pain in the cervical area as the main complaint. Neck disability index greater than 5. Absence of a history of surgery, fracture or severe injury in the cervical region. Absence of allergies or injuries in both ears. Consent not to receive other treatments during the study period, except analgesics, if necessary.	Pregnancy. Serious injuries or signs of infection in one or both ears. Serious systemic pathologies such as autoimmune diseases or cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-4wtq84v	Auriculotherapy in the treatment of gestational nausea and vomiting: a randomized clinical trial	Not yet recruiting	Intervention	2022-01-13	<NULL>	<NULL>	5312	Technological innovations and integrative and complementary therapies in obstetric care	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-4wtq84v	<NULL>	"Pregnant women referred to the AEHU (Ambulatório de Especialidades do Hospital Universitário) from prenatal care at usual risk will be included, and pregnant women at usual risk attended at the basic health units of the network of the city of Londrina, Paraná, with chronological age over 18 years old; gestational age between 5 and 16 weeks confirmed by ultrasound, regardless of parity, who report symptoms of nausea and/or vomiting of a mild degree (PUQE score less than 6) or moderate (PUQE score between 7 and 11)
*PUQE: (Pregnancy Unique Quantification of Emesis)"	Pregnant women with diagnosed mental retardation and suicidal idealization will be excluded; coagulation disorders; in pharmacological treatment for psychosomatic illness such as anxiety and depression; hyperthyroidism; dermatological lesion in the pinna; unexplained fever; multiple pregnancy; gestational trophoblastic disease, hyperemesis gravidarum; use of antiemetic; diarrhea; pregnant women with fetuses with Down syndrome, and pregnant women afraid to receive the semi-permanent needle	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-10kf7dvz	Auriculotherapy to reduce back pain in cleaning workers	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8553	Auriculotherapy in reducing chronic spinal pain in hospital cleaning service workers: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-09-16	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Must be at least 18 years old, of either sex; availability for auriculotherapy sessions; medical diagnosis of chronic pain (minimum duration of three months) or pain in the last year and in the last seven days (according to the assessment of the standardized Nordic questionnaire) in the region of the spine (neck pain, chest pain and/or lower back pain), including the regions between the first cervical vertebra and the gluteal fold; and pain intensity with a corresponding value of at least 4, on the numerical pain scale	Being pregnant; diagnosed with kidney stones with surgical indication; reporting allergy to seeds; having inflammation in the auricle; already undergoing treatment for chronic musculoskeletal pain with alternative therapies; being on new medication in the last 30 days (in order to avoid confusion of interventions)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:13
RBR-5pc43m	Auriculotherapy to reduce pain, anxiety and improving the quality of life	Recruiting	Intervention	2016-04-19	<NULL>	<NULL>	804	Effectiveness of auriculotherapy to reduce pain and anxiety and improving the quality of life of nursing professionals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-26	Escola de Enfermagem da Universidade de São Paulo	Leonice Fumiko Sato Kurebayashi	https://ensaiosclinicos.gov.br/rg/RBR-5pc43m	<NULL>	The subjects of the nursing staff (auxiliaries, technicians and nurses) that present a score above 33 points according to the State-Trait Anxiety Inventory (middle and high level of anxiety) and those who have availability of time for submission to the sessions.	Pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressants during the period of research; those who have metal and adesive tape allergy and who initiate other complementary therapies (acupuncture, massage, herbal medicine, Reiki, Flower therapy etc.) for anxiety control during the period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-648sztz	Auriculotherapy used to control anxiety	Recruitment completed	Intervention	2024-07-30	<NULL>	<NULL>	7166	Use of auriculotherapy to control anxiety in dental clinical practice	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Centro Universitário do Leste de Minas Gerais	Centro Universitário do Leste de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-648sztz	<NULL>	Individuals treated at the Dental School Clinic; of both sexes; aged over 18; no cognitive deficit; who agreed to participate in the study after reading and signing the Informed Consent Form	Individuals under 18 years of age; who do not wish to participate in the study; or present cognitive deficit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-3vn9c5q	Autogenous Bone Block versus Collagenated Xenogeneic Bone Block to evaluate treatment concept for reconstruction of atrophic alveolar ridge: a non-inferiority randomized clinical trial	Data analysis completed	Intervention	2021-09-16	<NULL>	<NULL>	4894	Randomized controlled clinical trial to evaluate the concept of treatment for atrophied alveolar ridge reconstruction using Collaged Xenogenic Bone Block (CXBB) versus Autogenous Bone Block (ABB) treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Faculdade de Odontologia da Universidade de São Paulo	Geistlich Pharma AG	https://ensaiosclinicos.gov.br/rg/RBR-3vn9c5q	<NULL>	Written informed consent; Age 18 years or older; Partial edentulism (up to 4 missing adjacent teeth); Atrophied alveolar ridge with one or more adjacent missing teeth; Atrophied alveolar ridge with residual ridge width of ≤ 4 mm; Sufficient bone height at the surgical site for implant placement	General contraindications for dental and/or surgical treatments; Periodontitis or Peri-implantitis; Probing depth &gt; 4mm at the adjacent teeth; Inadequate oral hygiene (PI&gt;1); Knife-edge morphology of the alveolar ridge; Implants adjacent to the surgical site; Inflammatory disease of oral cavity; Immunological impairment; Allergy to collagen; Diabetes; History of myeloma, respiratory tract cancer, breast cancer, prostate cancer or kidney cancer requiring chemotherapy or radiotherapy within the past five years; Previous, concurrent or planned radiotherapy of head area; Concurrent or previous immunosuppressant, bisphosphonate, high-dose or long-term corticosteroid therapy; Smokers or subjects who did not quit smoking at least 3 months prior to the surgery; Pregnant or lactating women; Women of childbearing age, who are not using a highly effective method of birth control; Participation in an investigational device, drug or biologics study within the last 26 weeks prior to the study start; Participation in any other clinical investigation during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-7sxmn7	Autologous Platelet-Rich Fibrin Membrane: new perspectivein the treatment of wounds in lower members	Recruiting	Intervention	2018-08-09	<NULL>	<NULL>	2107	Autologous Platelet-Rich Fibrin Membrane: new perspectivein the treatment of trophic lesions in lower members	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-18	Fundação Educacional da Região de Joinville-UNIVILLE	Fundação Educacional da Região de Joinville-UNIVILLE	https://ensaiosclinicos.gov.br/rg/RBR-7sxmn7	<NULL>	"Older than 18 years; both genders; voluntarily agree to participate; sign the
Term of Free and Informed Consent; present trophic lesions in lower limbs with more than 30 days duration; Wounds with 1cmx1cm at 8cmx8cm; not submitted to hyperbaric oxygen therapy."	"Trophic lesions of lower limbs smaller than 1cm x 1cm or larger
8cmx8cm; submitted to hyperbaric oxygen therapy; voluntary withdrawal at any time during the research"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-88cjpb	Automated screening to assess and manage the use of alcohol, tobacco and other substances	Not yet recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3581	Feasibility and acceptability of implementing an automated self-screening to assess and manage the use of alcohol, tobacco and other substances	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Raquel Brandini De Boni	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-88cjpb	<NULL>	HIV-positive individuals; with 18 years or more; under care at INI-FIOCRUZ; who are included in the HIV-INI cohort	NA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-92r54q	Autonomic heart modulation in children and adolescents with Cerebral Palsy during task using virtual Technology	Not yet recruiting	Intervention	2019-02-25	<NULL>	<NULL>	2488	Autonomic cardiac modulation in children and adolescents with Cerebral Palsy during Virtual Reality task and its correlations with participation and functionality	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-09	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92r54q	<NULL>	Children and adolescents of both groups should be aged from 5 to 21 years old, also they must have a clear understand of the proposed activities. Statement of informed consent will be signed by a legal guardian. All participants from the experimental group (GCP) should have diagnosis of cerebral palsy. Additionally, they should be classified at levels I, II, or III of the Manual Ability Classification System (MACS). To standardizes the sample according to ICF, participants with CP should present musculoskeletal functions in the mobility of several joints of the upper limbs with mild and moderate deficiencies (b7101.1 and b7101.2), trunk muscle tonus with mild deficiency (b7355.1) and mild or moderate upper limb tonus (b7358.1 and b7358.2). Regarding to learning, application of knowledge, accomplishment of tasks and communication all individuals will have light deficits in concentration and attention (d160.11), in performing a simple task (d2100.11) and in receiving oral messages (d310.11). These domains were chosen because they are the most important to enable the execution of the proposed task of touching the computer key at the exact moment or enabling to move towards the virtual environment.	Children that have undergone surgical procedures or has taken neurolytic block 12 months prior to the training sessions will be not included in the present research. Children with Gross Motor Function Classification System (GMFCS) level V (most severe CP) or who have severe visual or hearing impairments, or photosensitive epilepsy will be excluded. Furthermore, children with other pathologies and secondary disabilities will also be excluded, such as orthopedic deformity with indication for surgery, Epilepsy, Metal implant in the skull or use of hearing aids. ?	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-64ktszb	Autonomic Telerehabilitation in patients with Vasovagal Syncope	Recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6251	Influence of sleep duration in the occurrence of Vasovagal Syncope treated with Autonomic Rehabilitation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-64ktszb	<NULL>	Patients with a clinical diagnosis of vasovagal syncope with at least 1 syncope episode or 2 pre-syncope episodes in the last 3 months; both sexes; aged between 18 and 65 years	Shift workers; patients with neurological diseases; diabetes mellitus; morbid obesity; pregnant women; previous cardiovascular events; obstructive sleep apnea; disabling illnesses; cognitive impairment; eye diseases that affect the pupillary reflex; history of anterior segment trauma; history of eye surgery; users of eye drops or systemic drugs that affect pupillary diameter; volunteers without internet access; patients who did not reach the minimum recommended performance in functional capacity tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-23khtjk	Autotransplantation of dental pulp from third molars into teeth with endodontic needs	Recruiting	Intervention	2021-09-03	<NULL>	<NULL>	4859	Autogenous Transplantation of dental pulp from third molars into teeth with Irreversible Pulpitis and Pulp Necrosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-25	Universidade Federal do Rio Grande do Norte	Departamento de odontologia	https://ensaiosclinicos.gov.br/rg/RBR-23khtjk	<NULL>	Patients who need endodontic treatment; presence of formed third molars; receptor teeth uniradicular	Patients under 18 years old; third molars with complicated extractions or that require dental section; little remnant of healthy teeth or that need the placement of intraradicular pins	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-8j5pv5	Avaliação da capacidade de respiração espontânea para retirada do ventilador mecânico em recém-nascidos pré-termo	Recruiting	Intervention	2020-03-11	<NULL>	<NULL>	4814	Evaluation of the duration of the Spontaneous Breathing Test in the prediction of extubation in preterm newborns	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-08	Real Hospital Português de Beneficência em Pernambuco (RHP)	Real Hospital Português de Beneficência em Pernambuco (RHP)	https://ensaiosclinicos.gov.br/rg/RBR-8j5pv5	<NULL>	Preterm newborn; gestational age less than 37 weeks; birth weight less than 1500g; using invasive mechanical pulmonary ventilation for at least 24 hours; be submitted to the first extubation attempt; presenting adequate gas exchange indicated by partial arterial oxygen pressure (PaO2) greater than 60 mmHg with FiO2 less than 0.4 and Support Pressure less than 16 cmH2O	Neurological or cardiac malformations; genetic syndromes; hemodynamic instability; signs of respiratory distress; inadequate tissue perfusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-3qhwjj	Avaliação do tratamento com a luz e as lesões pré-malignas da face e do couro cabeludo comparando duas diferentes técnicas de iluminação.	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2734	Pain evaluation during photodynamic therapy of the field of cancerization of the face and scalp comparing two different lighting techniques: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-02	Universidade Julio Mesquita Filho	Fundação Hospital Amaral Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-3qhwjj	<NULL>	Sign the free and informed consent form (TCLE - Annex1);Age over 50, of both sexes; Holders of at least 3 bilateral QAs with clinical similarities between hemifaces / hairy hairs; No treatments in the last 3 months.	Women of gestational age not using contraceptives; History of skin photosensitization; Hypersensitivity to porphyrins; Photodermose; Any associated immunosuppressive conditions (eg, HIV, systemic disease, use of corticosteroids, kidney transplant recipients). Note: patients with multiple QA criteria on the face and simultaneously on the scalp, will only be included in the most compromised region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-63rw34	Avaliation of effectiveness of a preemptive analgesia protocol in the extraction f third lower molars	Recruitment completed	Intervention	2019-12-03	<NULL>	<NULL>	3243	Efficacy of different analgesy protocols in the extraction of mandibular third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-17	Universidade Federal do Ceará- Campus Sobral	Universidade Federal do Ceará- Campus Sobral	https://ensaiosclinicos.gov.br/rg/RBR-63rw34	<NULL>	Having lower third molars; any indication of extraction; being over eighteen years old and less then forty years old; having teeth in similar positions according to the Winter and Pell and Gregory classifications; having teeth with at least two thirds of root formation	Allergies or adverse reactions to medications used; presence of any tooth-associated pathology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8qqzk8	Avaliation of efficacy of Trial-Based Cognitive Therapy in the adherence to drug treatment in HIV-infected patients	Recruitment completed	Intervention	2016-08-24	<NULL>	<NULL>	972	Controlled trial comparing the efficacy of Trial-Based Cognitive Therapy (TBCT) and standard treatment about the adherence to the treatment of patients with HIV/AIDS  with antiretroviral therapy failure assisted in Salvador, Bahia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-16	Fundação Bahiana de Infectologia	Universidade Federal de Bahia	https://ensaiosclinicos.gov.br/rg/RBR-8qqzk8	<NULL>	HIV-infected patients with viral load higher than 500 copies/mL in the last two tests or virologic controlled due to non-adherence to antiretroviral therapy. Age between 18 and 65 years, to be able to write and follow the protocol&apos;s instructions and sign informed consent.	Difficult with reading and whitting activities; the patient can not participate in another psychological therapy, and he can not have psychiatric or clinical diagnosis that interferes in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-6ggm2pn	Awareness Raising Interventions in Schools: Education on aging and brain health for teachers	Recruitment completed	Intervention	2025-06-26	<NULL>	<NULL>	8071	EnvelheCiência	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6ggm2pn	<NULL>	All teachers and support staff from the two public schools and the adult literacy program in São Carlos; from both sexes	Refusal to sign the Free and Informed Consent Form - FICF	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-89rvgg	Axillary web syndrome -  Physical therapy treatment after Breast cancer surgery.	Recruiting	Intervention	2019-09-11	<NULL>	<NULL>	2933	Axillary web syndrome - Clinical trial of physiotherapeutic conduct after Breast cancer surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-21	Patricia Vieira Guedes Figueira	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89rvgg	<NULL>	Women from 18 years of age. Invasive or non-invasive breast cancer. Breast cancer surgery (mastectomy, quadrantectomy, lumpectomy), with some axillary procedure: Sentinel Lymph Node Biopsy (SLNB) or Axillary Lymph Node Dissection (DLNA). Presence of axillary web syndrome in the evaluation. Voluntary consent.	Previous surgeries in shoulder, breast ou axilla.Anterior orthopedic or rheumatic shoulder changes, such as frozen shoulder, cuff injury, impact syndrome, arthritis, fractures, and arthritis. Immediate reconstruction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-76kmb7g	Ayahuasca in the treatment of alcohol addiction	Recruitment completed	Intervention	2026-04-06	<NULL>	<NULL>	9057	Effects and therapeutic potential of ayahuasca in alcohol use disorder	<NULL>	1-2, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Men and women aged 25 or older; currently diagnosed with alcohol use disorder; concerned about their drinking habit; with preserved cognitive abilities; and with a family member or friend who can pick them up after ayahuasca sessions	presence of kidney liver heart or esophageal diseases; presence of psychiatric symptoms (acute psychosis suicidal ideation bipolar disorder or severe symptoms of depression or anxiety); current use of selective serotonin reuptake inhibitor drugs or monoamine oxidase inhibitors at the time of the study; current use of natrexone disulfiram acomprosate methylphenidate or baclofen; clinical indication for hospitalization; clinical indication for the treatment of alcohol withdrawal symptoms	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-10h8j7q7	Ayla App: Socio-environmental Models that lead to Maternal, Fetal, Neonatal and Infant Consequences	Recruiting	Intervention	2023-05-30	<NULL>	<NULL>	6120	Ayla App: Social and Environmental Models influencing Maternal, Fetal, Neonatal and Children´s Outcomes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-26	Universidade da Região de Joinville	Secretaria Estadual de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-10h8j7q7	<NULL>	"Primiparous pregnant women without previous comorbidities defined at the time of randomization; Literate in the language Portuguese; Aged 18 to 34 years old or older; With gestational age up to 13 weeks considering the date of the last menstruation; Which have the date of the last menstruation defined; Who have planned the birth at Maternidade Darcy Vargas (MDV); Who have a mobile device compatible with the Ayla app and who voluntarily accept to participate in the research by reading and assent of the TCLE being informed the free will to stop participating in the research at any time
time"	Definition of gestational age outside the 1st trimester after performing obstetric ultrasonography (USG); Multiple pregnancy identified later; Abortion during the research; Delivery in a different place other than the Maternity Darcy Vargas; Withdrawal after signing the consent form; Loss of segment of the pregnant woman due to abandonment of follow-up and inability to contact by telephone (including loss or change of telephone number or cell phone)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-9pqqpb	Azithromycin in the treatment of Chronic sinusitis: clinical and biopsy evaluation in a controlled study	Recruiting	Intervention	2017-11-16	<NULL>	<NULL>	1483	Azithromycin in the treatment of Eosinophilic nasossinusal polypose: clinical and histomorphological analysis in a randomized masked study with placebo	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9pqqpb	<NULL>	Patients with eosinophilic nasosinusal polyposis; above 18 years of age; with a percentage of eosinophils equal to or greater than 40% that at clinical and endoscopic examination do not present evidence of active nasosinusal infection (ex: purulent secretion in nasal fossa)	Patients with non-eosinophilic polyposis; younger than 18 years; such as cystic fibrosis; Kartagener&apos;s syndrome; antrochoanal polyp; eosinophilic nasosinusal polyposis in the presence of infection; and patients who used corticosteroids or antihistamines in the 15 days prior to the study .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-55f97c	B12 Effect of supplementation and pulmonary rehabilitation in aerobic performance in patients with chronic obstructive pulmonary disease: a randomized study	Recruiting	Intervention	2015-07-14	<NULL>	<NULL>	597	Eight-week effect of physical training with vitamin B12 supplementation on functional capacity in patients with Chronic Obstructive Pulmonary Disease (COPD )	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade Federal de Mato Grosso do Sul - UFMS	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-55f97c	<NULL>	Volunteers with chronic obstructive pulmonary disease stages III and IV of the GOLD second disease; both sexes ; aged between 40 and 80 years ; at least four weeks free of disease exacerbation ; former smokers ; Current diagnosis or without other cardiopulmonary conditions such as asthma , interstitial lung disease , pulmonary hypertension , cardiac insufficiency or arthropathy , which does not allow exercise tests .	"Volunteers with Chronic Obstructive Pulmonary Disease stages I and II of the disease according to GOLD criteria; participating in any program
cardiopulmonary rehabilitation ; which show no ability to perform pulmonary function tests, gradual or exhaustive effort load
constant; Volunteers with heart disease, dilated bronchi , rheumatic diseases , physical deformities that prevent the achievement of exercise or
that are not available to participate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-2q63v4h	Bacteria-produced dressing for treating wounds in diabetic patients	Not yet recruiting	Intervention	2025-11-14	<NULL>	<NULL>	8510	POLYTISSUE film associated with bacterial cellulose hydrogel for the treatment of venous ulcers in diabetic patients	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Universidade Federal de Alagoas (UFAL)	<NULL>	<NULL>	<NULL>	Adults with a diagnosis of non-infected venous ulcer in the granulation phase; with or without diabetes.	Pregnant women; allergy to the compound; venous ulcers resulting from trauma or any other non-chronic superficial skin lesions; significant systemic infection; cognitive deficit that prevents participation in the research; voluntary request to withdraw from the research.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:31
RBR-5c3tb9	Bacterial adherence to silk and nylon suture	Data analysis completed	Intervention	2020-06-24	<NULL>	<NULL>	3948	"Efficacy of antiseptic ointment in preventing of
bacterial contamination on suture"	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-04-03	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5c3tb9	<NULL>	Moth genders. Older than 18 years. With indication of extractions of minimum of two teeth in both hemiarchs of the same dental arch.	Patients with systemic diseases. Patientes with  local changes sugestinf infecction. Patients allergic to the components of the ointment. Patients with reports of antimicrobial use in the last 15 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-9f3sm9	Balance among patients with Parkinson&apos;s disease after physical therapy intervention using Nintendo wii®	Recruitment completed	Intervention	2015-07-21	<NULL>	<NULL>	553	Evaluation of static and dynamic balance of patients with Parkinson&apos;s Disease before and after physical therapy intervention using the Nintendo Wii® the rehabilitation process	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Universidade de Mogi das Cruzes	Universidade de Mogi das Cruzes	https://ensaiosclinicos.gov.br/rg/RBR-9f3sm9	<NULL>	to present a confirmed diagnosis of Parkinson&apos;s Disease; degree of involvement of Parkinson&apos;s Disease between 2.5 to 3.0 on the Hoehn and Yahr scale ; Being currently in service in Brazil Parkinson Association (BPA); have availability to perform physiotherapy on BPA 2 times a week for 01 months, with duration of 1 hour; make use of medicament for Parkinson&apos;s Disease.	presence of moderate to severe musculoskeletal complaints, in which the pain or deformity impossible to maintain bipedalism for extended periods, vestibular complaints; autonomic dysfunction; symptoms suggestive of cognitive changes detectable by the test Mini Mental State Examination; weigh more than 150 kg (maximum weight supported by the gaming platform).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-8djnqpf	Balance exercise program with unstable base, aerobic demand and cognitive task: effects in the elderly	Recruitment completed	Intervention	2023-10-23	<NULL>	<NULL>	6529	Dynamic body balance training in association with support base malleability, aerobic demand and cognitive task: effects in healthy elderly subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-12	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8djnqpf	<NULL>	not having musculoskeletal; sensory or neurological diseases that could affect body balance; not using medications that affect balance	Participants will be excluded if they do not present the minimum attendance stipulated; injuries that disable the participation of volunteers, failure to perform the tasks proposed in class.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-5nvrwm	Balance Exercises in Fall Prevention and quality of living in elderly	Recruitment completed	Intervention	2017-09-18	<NULL>	<NULL>	1378	Balance Exercises Circuit on fall prevention and quality of living in elderly: a follow-up estudy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Departamento de Saúde Coletiva	Faculdade de Educação Física	https://ensaiosclinicos.gov.br/rg/RBR-5nvrwm	<NULL>	Healthy elderly volunteers; age between 60 and 80 years; both genders; sedentary.	Physical or functional conditions that could be aggravated as a result of the proposed activities or that could prevent full participation in the study such as dementia, Alzheimer’s disease, Parkinson’s disease, use of prosthesis in the lower limbs, and participation in regular and targeted physical activity.Age less than 60 years and over 80 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-3jmx67	Balance rehabilitation with virtual reality exercise protocol in Neurological Diseases.	Recruitment completed	Intervention	2020-01-29	<NULL>	<NULL>	3421	Vestibular Evaluation and Rehabilitation in Diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-02	Instituto Federal do Paraná	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3jmx67	<NULL>	Patients aged 15 to 18 years; patients with hereditary spastic paraplegia (PEH); patients without musculoskeletal disorders.	Patients with otological alteration; patients unable to meet and understand simple verbal command; patients with visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-539w5nw	Balance Training through Virtual Rehabilitation in patients who have suffered a Stroke	Recruitment completed	Intervention	2022-07-08	<NULL>	<NULL>	5473	Balance Training in hemiparetic patients through Virtual Rehabilitation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-04-20	Centro Universitário Central Paulista	Centro Universitário Central Paulista	https://ensaiosclinicos.gov.br/rg/RBR-539w5nw	<NULL>	Volunteers who suffered ischemic stroke; of both genders; age between 30 and 60 years; sequelae of hemiparesis for at least 6 months	Volunteers who had other illnesses not related to the stroke; those who were in the acute or subacute phase of the disease; those who suffered a hemorrhagic stroke; hemiplegics; amputees; wheelchair users or orthotics; visually and/or hearing impaired; those who could not understand or respond to data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-9crkxr	Barriers to perform home tasks oriented soon after stroke.	Not yet recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2502	Barriers to orientation adherence for the practice of home-based tasks in the subacute post stroke phase.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9crkxr	<NULL>	Individuals with primary stroke; individuals with subacute AVE; No cognitive problems that impair participation in the research, evaluated through the Mini Mental State Examination (MMSE), presenting scores higher than 13 for illiterates and 18 points with school instruction (BERTOLUCCI et al, 1994); Age above 18 years; Residents of the region of Florianópolis and Greater Florianópolis; Do not have other neurological deficits (eg Parkinson&apos;s disease) and / or orthopedic not related to stroke.	Presence of hearing disorders that may compromise communication with the evaluators, presenting another stroke event or other health emergency that requires hospitalization during the period of data collection; not to remain in the home environment after hospital discharge in the subacute phase after stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-5ysj54	BCG vaccine use to prevent COVID-19 in health care workers	Not yet recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4047	BCG vaccine as preventive measure against COVID-19 in health care workers	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-07-15	Universidade Federal do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5ysj54	<NULL>	Individuals aged above 18 years old, male or female, not infected with SARS-CoV-2 who exercise professional activities in the Health Units of the study; Agreement to participate in the study by signing the informed consent form	Professionals with a history of infection confirmed by SARS-CoV-2 or who have already been diagnosed with COVID-19 prior to the study; Individuals who have not performed confirmatory tests for COVID-19; Pregnancy or breast-feeding; Non-permanence in activities in the Health Units after 6 months of enrollment in the study; Individuals with primary or acquired immunodeficiency; Individuals with malignant neoplasms; Patients on high-dose corticosteroids (equivalent to a prednisone dose of 20 mg / day or more) for more than two weeks; Patients using other immunosuppressive therapies (antineoplastic chemotherapy, radiation therapy, among others); Individuals with autoimmune diseases;  Dermatological disorders at the vaccine site or generalized; Individuals under treatment for active tuberculosis; Individuals with report of fever (axillary temperature&gt; 38 ° C in the last 48h)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-6grmm4g	Beach Tennis versus Combined Training on 24-hour Blood Pressure	Recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9069	Effects of recreational beach tennis versus combined training on 24-hour ambulatory blood pressure	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-31	Hospital de Clínicas de Porto Alegre	<NULL>	<NULL>	<NULL>	Men and women; Aged 50 to 80 years; medically diagnosed with hypertension; using up to two antihypertensive medications; willing to participate and sign the informed consent forms; office blood pressure between 130-179 and 80-110 mmHg	Diseases that limit the performance of physical exercises, such as lung disease, valvular heart disease, and renal failure; underlying cardiovascular disease previously diagnosed by a physician, occurring in the last 24 months, such as acute myocardial infarction, angina or stroke, or heart failure; diseases that reduce life expectancy; regular physical activity practitioners (i.e., 3 or more sessions per week of high intensity exercise moderate or vigorous); body mass index greater than 39.9 kg/m²; diabetic proliferative retinopathy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-52pq3b	Bed bath with tub / basin and bath bag: micro-biological case-control and cost evaluation	Recruiting	Intervention	2016-01-22	<NULL>	<NULL>	689	Conventional Bath bed and Bath Bag: case-control microbiological, cost evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Universidade Estadual Paulista Julio de Mesquita Filho	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-52pq3b	<NULL>	dependence on the nursing team; impaired physical mobility; bedridden in the ward admission; up to 48 hours of hospitalization.	partial dependence on the nursing team; They are not bedridden; show on mechanical ventilation; infectious disease of skin and soft tissue (cellulitis; erysipelas; eczema); skin ulcers; pressure; venous; infectious or tumor; previous use of antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-93s444p	Bedside Sitting and Respiratory Muscle Training for Critically Ill Intensive Care Unit ICU Patients	Recruiting	Intervention	2024-10-04	<NULL>	<NULL>	7401	Bedside Sedestation and Inspiratory Muscle Training for Critical Intensive Care Unit (ICU) Patients: A Randomized Clinical Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Hospital de Clínicas da Universidade Estadual de Campinas	Hospital de Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-93s444p	<NULL>	Patients over 18 years of age; of both sexes; who have been on invasive mechanical ventilation for a period of 5 days or more will be selected; patients must be hemodynamically stable and on low doses of vasopressor drugs; patients sedated with a Richmond Agitation Sedation Scale (RASS) score between 0 and -2; patients without sedation with a Glasgow Coma Scale score of 9 or higher; patients with adequate gas exchange and stable parameters: positive end-expiratory pressure (PEEP) &lt; 10 cmH2O, inspired oxygen fraction (FiO2) &lt; 0.6, oxygen saturation (SpO2) ≥ 90%	Patients who present the following contraindications for bedside sitting and inspiratory muscle training will be excluded from the study; patients who are hemodynamically unstable and on high doses of vasopressor drugs; patients with worsening gas exchange: inspired oxygen fraction (FiO2) greater than or equal to 0.5; patients with restrictions on changing position: spinal cord injury, increased intracranial pressure, need for logrolling, fractures that prevent sitting at the bedside; participants randomized to the control group, who during hospitalization present a reduction in maximum inspiratory pressure (≤30 cmH2O), will be excluded from the study to undergo inspiratory muscle training according to the institutional muscle training protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-5pwcs47	Bedwet in snoaring children	Recruiting	Intervention	2021-05-27	<NULL>	<NULL>	4678	Primary Nocturnal Enuresis in patients with Upper Airway Obstruction	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Hospital Universitário da Universidade Federal de Juiz de Fora - HU UFJF	Hospital Universitário da Universidade Federal de Juiz de Fora - HU UFJF	https://ensaiosclinicos.gov.br/rg/RBR-5pwcs47	<NULL>	Study Group: Volunteers children between 5 and 14 years with primary nocturnal enuresis AND upper airway obstruction; Control Group: Volunteers children between 5 and 14 years with primary nocturnal enuresis without upper airway obstruction	Volunteers children between 5 and 14 years with primary nocturnal enuresis with or without upper airway obstruction but with any neurological desease , urological desease, psicological desease and also any metobological desease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-7sp8mf	Beetroot leaves (Beta vulgaris L.) supplememntation improve biochemical and anthropometric parameters of Obese and Dislipidemic patients	Recruitment completed	Intervention	2018-07-19	<NULL>	<NULL>	2033	Beetroot leaves and stalks (Beta vulgaris L.): characterization and effects of antioxidant capacity in Obese and Dyslipidemic individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-04	Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-7sp8mf	<NULL>	Men or women aged 20 to 59 years; Body Mass Index (BMI) for obesity grade I or II (between 30 and 39.9kg/m2); presenting changes in serum lipid levels with total cholesterol &gt;200mg/dl and LDL-cholesterol above 130mg/dl, as prescribed by the Brazilian Society of Cardiology	Patients with renal or hepatic impairment, volunteers who underwent bariatric surgery and who suffered stroke	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-26wwhz	Behavior in virtual task of people with Down syndrome	Recruiting	Intervention	2018-06-27	<NULL>	<NULL>	1936	Analysis of virtual task performance in people with Down syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-26wwhz	<NULL>	Medical diagnosis of Down Syndrome; cognitive conditions to understand the orientations in relation to the task proposed in each game; and to be able to perform the necessary movement and not present symptoms of pain or discomfort during the execution of the tasks; authorization of the responsible, with the signed free informed consent term and free and informed consent term.	People with cognitive impairments that make it impossible to collaborate and understand simple orders in the proposed activities; Functional deficiencies that impede the accomplishment of the tasks; Withdrawal during the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-4m6zdh	Behavior of multiple sclerosis patients&apos; view in computer use	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1958	Evaluation of the visual performance of people with multiple sclerosis in the use of tasks in virtual environment	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Escola de Artes, Ciências e Humanidade da Universidade São Paulo	Escola de Artes, Ciências e Humanidade da Universidade São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4m6zdh	<NULL>	All patients with multiple sclerosis; Both sexes; aged between 21 and 80 years; that presents some type of visual deficit except total or partial blindness	Deformity or muscle weakness in the upper limbs that prevent the manipulation of the equipment; outbreak in the last month; surgery or chemical neuromuscular block in the upper limbs in the last two months before participating in the study; presence of disorders in cognitive function and vision that potentially undermine the understanding of the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-4hsbjz	Behavior of parents and caregivers for the management and control of childhood Asthma: Clinical Trial with flipchart and Motivational Interview	Not yet recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4208	Flipchart for Promoting the Self-Efficacy of parents and/or caregivers in the management and control of childhood Asthma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4hsbjz	<NULL>	Parents and/or caregivers of at least one child between 2 to 12 years old with an established medical diagnosis of asthma; prescribed inhalation treatment; with or without the use of a spacer; accompanied at the Primary Care Unit Health; have a cell phone or landline.	Parents and/or caregivers with apparent cognitive limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-43dhh6	Behavior of parents/caregivers to control and manage childhood asthma: clinical trial with different technologies	Recruiting	Intervention	2020-08-31	<NULL>	<NULL>	4194	The use of educational technologies to promote the self-efficacy of parents/caregivers for the management and control of childhood asthma	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-43dhh6	<NULL>	Parents/caregivers of at least one child from two to 12 years of age, with an established medical diagnosis of asthma and prescribed inhalation treatment, with or without the use of a spacer, who must be accompanied at the basic health unit, and have telephone contact. These must be at least 18 years of age.	Parents/caregivers with cognitive limitations that prevent them from participating in educational interventions or responding to research instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-93ykhs	Behavioral and educational intervention: effects on return visit rates to receive the results of the Pap smear	Data analysis completed	Intervention	2015-09-15	<NULL>	<NULL>	613	Behavioral and educational intervention: effects on adherence of women to return visit to receive the results of the Pap smear	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-09-01	Universidade Federal do Ceará	Centro de Saúde da Família Aída Santos e Silva	https://ensaiosclinicos.gov.br/rg/RBR-93ykhs	<NULL>	"The size of the target shows: 775 women.
The sample selection followed the following eligibility criteria: have initiated sexual activity and perform the Pap smear in the data collection period. Minimum age: 18 years and maximum: 80 years."	As defined exclusion criteria were: present cognitive limitations that prevent them from answering the questionnaire, to participate in educational or behavioral intervention; and we have not done for any reason, cytologic collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-439f77	Behavioral intervention about adherence to oral antidiabetic to treatment of diabetes mellitus	Data analysis completed	Intervention	2016-01-12	<NULL>	<NULL>	4826	Effect of strategies &quot;action planning and coping planning&quot; about adherence to oral antidiabetic agents: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-11	Faculdade de Enfermagem da Universidade Estadual de Campinas - Unicamp	Faculdade de Enfermagem da Universidade Estadual de Campinas - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-439f77	<NULL>	Patients of both genders with diabetes mellitus,type 2; adults over 18 years; continuous use for at least six months of oral antidiabetic agents; show an average score intention greater than or equal to 4.	Drug administration by a caregiver; use insulin to treat diabetes mellitus; make diabetes monitoring in other health service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-78s7nmn	Behavioral profile of patients with chronic back pain	Recruiting	Intervention	2023-01-31	<NULL>	<NULL>	5851	Behavioral profile of patients with Central Sensitization after Biopsychosocial Treatment	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-30	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-78s7nmn	<NULL>	Chronic low back pain; Risk os central sensitization; More than 18 years; Pain intensity superior to three; both sexes	Cognitive decline; Red flags; Nerve root impairment; cardiorrespiratory disease; Body mass index superior to 35 kg/m2; Pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-7nc5wq	Behavioral Treatment for Insomnia	Recruiting	Intervention	2017-08-16	<NULL>	<NULL>	4388	Acceptance and Commitment Therapy for Insomnnia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Hospital das Clinicas da Faculdade de Medicina da USP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7nc5wq	<NULL>	Present one or more of the following symptoms with a frequency of three or more nights per week, with persistence for at least one month: Sleep onset latency greater than or equal to 30 minutes;  Time agreed upon falling asleep or equal to or greater than 30 minutes; Early awakening at least 30 minutes earlier than desired; Non-restorative sleep complaint despite favorable circumstances for sleep.	Non-stabilized clinical or psychiatric comorbidities;  Use of illicit drugs and alcohol; Illiteracy and cognitive disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-2nwkr47	Belly time in the development of premature newborns	Recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5223	Tummy time intervention in the neuromotor development of preterm newborns - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-30	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2nwkr47	<NULL>	Participants will be selected according to the following criteria: (1) neonates born between 30 wk and 36 wk and 6 days, according to ultrasound; (2) adequate for gestational age; (3) Apgar ≥ 7 in the 5th minute; (4) birth weight less than 2500 g; (5) intrauterine growth restriction (6) absence of cardiorespiratory complications such as bronchopulmonary dysplasia and congenital heart diseases, neurological such as brain malformation, microcephaly, hydrocephalus, musculoskeletal disorders such as congenital clubfoot and congenital muscular torticollis, or auditory according to the little ear test; genetic syndromes, congenital infections (toxoplasmosis, syphilis, rubella, cytomegalovirus and herpes simplex) and visual changes according to the little eye test; (7) present poor or normal motor repertoire in the assessment of Generalized Movements (MG).	The following will be excluded: (1) babies diagnosed with grade III and IV intraventricular hemorrhage; (2) babies whose parents withdraw from participating (3) babies who do not attend 2 assessments to monitor primary and secondary outcomes, (4) parents do not answer the phone for 3 consecutive days to reschedule assessments or declare withdrawal from the intervention by of the guardians, (5) parents who do not fill out the field diary to monitor the practice of Tummy Time. After randomization, participants will be excluded if they present any health deterioration and need to be hospitalized, change state and/or country.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-10c27qjq	BEM Program	Recruitment completed	Intervention	2021-07-13	<NULL>	<NULL>	4787	BEM Program (Play Teaches to Change): playing in the daily routine to promote child development.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-15	Diálogo e Inovação Marketing e Planejamento Limitada	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10c27qjq	<NULL>	Child aged 12 to 23 months who attend the day cares where the BEM Program was implemented, living in vulnerable urban areas and having a female reference adult who has a smartphone with internet access.	Children who have clinical conditions that interfere with the typical course of development.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:40
RBR-6vkxvvd	Benefical effects of meditation on chronic low back pain	Recruiting	Intervention	2022-12-15	<NULL>	<NULL>	5764	Effects of a online Mindfulness-based stress reduction program in individuals with chronic low back pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6vkxvvd	<NULL>	Volunteers from 19 to 64 years of age; having low back pain that has persisted for at least three months and has been a constant problem for at least half of the days in the past 6 months, as it characterizes chronic low back pain according to the recommendations of the National Institute&apos;s task force report of Health from National Institutes of Health on research standards for chronic low back pain; access to the internet; and consent and availability to undertake the MBSR program	No have previous participation in a Mindfulness meditation program; not filling in or having any error in filling in personal data, missing important information such as name, age and contact details; use of psychotropic drugs; psychological/psychiatric treatment; neuropsychiatric disorders (such as dementia, dyslexia, schizophrenia, depression, anxiety disorder, autism, etc; and serious chronic conditions, such as cancer, severe heart disease, active tuberculosis, Parkinson&apos;s disease, etc	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-7fy9gss	Benefício da Iodoterapia no Câncer de Tireoide com extensão e metástase no pescoço	Recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8623	Benefit of Adjuvant Therapy with I131 in patients with Differentiated Thyroid Carcinoma with minimal extrathyroidal extension and after re-operation for persistent or recurrent lymph node metastases	<NULL>	3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2017-01-01	Fundação Faculdade de Medicina	<NULL>	<NULL>	<NULL>	Patients with Differentiated thyroid carcinoma; minimal extrathyroidal extension; reoperation for persistent or recurrent lymph node metastases; aged over 18 years	Known distant metastases; distant metastasis diagnosed on whole-body scan with diagnostic I131	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-4742kxf	Benefit and safety of Physical Training with alternating High Intensity Exercise compared to Fixed Load Exercise in patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension	Recruiting	Intervention	2023-12-01	<NULL>	<NULL>	6627	Efficacy and safety of Cardiopulmonary Rehabilitation with High Intensity Interval Training compared to Constant Load Training in patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-14	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4742kxf	<NULL>	These are patients with a previous diagnosis of Pulmonary Arterial Hypertension or non-surgical Chronic Thromboembolic Pulmonary Hypertension or residual post-thromboendarterectomy; Modified New York Heart Association (NYHA) functional class I, II and III; Specific pharmacological treatment for Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension optimized and available in Brazil and stable for at least 3 months or at least 6 months post-thromboendarterectomy	Presence of syncope in the last 30 days or signs and symptoms of clinical instability in the last month, worsening of dyspnea, pre-syncope or need for increased diuretics due to edema or hospitalization; Other diagnosis of Pulmonary Hypertension group II, III and V; Functional class IV; Musculoskeletal diseases that contraindicate or impair carrying out exercise testing on a cycle ergometer or carrying out rehabilitation; Need for additional specific therapy during the rehabilitation period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-7j9rv5d	Benefit of Low Intensity Laser applied to the skin in relation to viral load, LT-CD4 + AND LT-CD8 + in patients living with HIV /AIDS	Not yet recruiting	Intervention	2021-01-27	<NULL>	<NULL>	4490	Effectiveness of Transcutaneous Laserherapy in relation to viral load, LT-CD4 + and LT-CD8 + in patients living with HIV/AIDS: randomized clinical trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-01-04	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7j9rv5d	<NULL>	Having HIV / AIDS; both sexes; over 18 years; reside in Botucatu; perform outpatient treatment at SAEI; not having cognitive deficit; have detectable viral load; do the same therapeutic regimen	Do not reside in Botucatu; not having cognitive deficit; have an undetectable viral load	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-4kf8zv	Benefit of physical therapy, yoga and music therapy for patients with Parkinson&apos;s disease	Recruitment completed	Intervention	2016-08-11	<NULL>	<NULL>	955	Effects of physiotherapy associated with yoga and music therapy in Parkinson´s disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4kf8zv	<NULL>	Individuals of both sexes; aged 40 to 70 years; diagnosed with Parkinson&apos;s disease; stage 1-3 Hoehn-Yard; able to walk independently; not be modified in drug treatment during participation in the study.	Other neurological disorders as heart disease and / or severe cognitive impairment that could affect the understanding and / or to indicate the completion of the exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-365tkt	Benefit of physiotherapy with semi-supervised training of dual task in motor performance and cognitive for people with Parkinson&apos;s disease	Recruitment completed	Intervention	2016-10-13	<NULL>	<NULL>	1035	Effectiveness of physiotherapy with semi-supervised training of dual task in motor performance and cognitive for people with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Poliana Penasso Bezerra	Universidade Federal de Santa Catarina (centro do pesquisador)	https://ensaiosclinicos.gov.br/rg/RBR-365tkt	<NULL>	Individuals of both sexes; aged 40 to 70 years; diagnosed with Parkinson&apos;s disease; stage 1-3 Hoehn-Yard; able to walk independently; not be modified in drug treatment during participation in the study.	Other neurological disorders as heart disease and / or severe cognitive impairment that could affect the understanding and / or to indicate the completion of the exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-5rh6cg	Benefits aquatic physical therapy in the trunk control in children with cerebral palsy	Recruitment completed	Intervention	2016-02-26	<NULL>	<NULL>	721	Aquatic physical therapy in the trunk control in children with cerebral palsy: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-10	Associação de Assistência à Criança Deficiente	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5rh6cg	<NULL>	Clinical diagnosis of spastic diparesis type of Cerebral Palsy; level IV to the Gross Motor Function Classification System (GMFCS); aged 4 years to 10 years and 11 months.	Uncooperative patients; unable to understand the proposed activities; undergoing orthopedic surgery or peripheral blocks less than 6 months ago.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-2sfhgyy	Benefits of Acupuncture for Sleep Bruxism in college students	Terminated	Intervention	2026-01-12	<NULL>	<NULL>	8741	Benefits of acupuncture on sleep bruxism in undergraduate students: prospective clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Odontologia do campos de Araçatuba - UNESP	<NULL>	<NULL>	<NULL>	The volunteers who participated in the research were of both sexes, over 18 years of age, suspected of having bruxism, regularly enrolled for at least 6 months in undergraduate courses of various kinds, from public and private institutions in the city of Araçatuba-SP, over 18 years of age, suspected of having bruxism, and who voluntarily agreed to participate in the research and were willing to receive acupuncture treatment	Exclusion criteria included students with psychiatric disorders and unstable, uncontrolled chronic diseases, those with a phobia of needles, those who had received acupuncture in the three months prior to the study, pregnant and breastfeeding students, students with valvular heart defects, bleeding disorders, those taking anticoagulants, those with any implanted electrical device (pacemaker, implantable cardioverter defibrillator, brain or spinal cord neurostimulator), those with infection or abscess located at any of the selected acupuncture points, those using non-steroidal anti-inflammatory drugs, paracetamol and opioid analgesics in the previous 5 days, steroidal drugs in the previous 30 days, and individuals suffering from acute oral pain such as pulpitis and dental fractures, and those who refused to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-3d29s2	Benefits of aerobic exercise on the cardiovascular system in patients with coronary artery disease.	Recruiting	Intervention	2014-12-09	<NULL>	<NULL>	361	Influence of interval aerobic exercise training on cardiorespiratory and metabolic variables and inflammatory markers in patients with different level of coronary artery lesions	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-14	Departamento de Fisioterapia da Universidade Federal de São Carlos	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3d29s2	<NULL>	Volunteers men, aged 35 and 65 years with coronary artery disease udergoing percutaneous coronary intervention (&gt; 3 months), and/or cardiovascular risk factor (obesity, smoking, drinking, sedentary lifestyle, hypertension, non-insulin-dependent diabetes and dyslipidemia).	Patients with frequent extrasystoles, chronic obstructive pulmonary disease, unstable angina, osteomuscular disorders, diabetes mellitus – users of insulin, renal failure, and sequelae of stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-29q75w	Benefits of an intervention with the use of an educational handbook in the support provided by caregivers in the delivery room	Not yet recruiting	Intervention	2019-05-01	<NULL>	<NULL>	2648	Effectiveness of intervention applied in maternity with use educational manual in the support provided by chaperone in delivery room	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Departamento de Enfermagem - Universidade Federal do Ceará	Maternidade Escola Assis Chateaubriand (MEAC)	https://ensaiosclinicos.gov.br/rg/RBR-29q75w	<NULL>	"The study population will be composed of two target groups: accompanying parturients who were admitted to the Maternity Center of the Maternity School Assis Chateaubriand (MEAC), between June and November of 2019; and puerperal women who have their companions involved in this research.
The population will be divided into two groups:
CONTROL GROUP (CG): group of accompanying persons eligible to participate in the research that will receive the routine guidelines, that is, guidelines performed in the delivery room by health professionals, academics, among others; as well as puerperal women who have their companions involved in this group. Thus, part of this group will be the puerperae and their respective participants who do not receive the educational intervention proposed by the researcher.
INTERVENTION GROUP (GI): group of companions to whom an intervention will be carried out using the educational manual; For this, after the accompanying person is authorized by the MEAC social service to accompany the delivery at the Obstetric Center; he will be invited to participate in the study and, if so, the educational intervention will be applied.
The joint reading of the manual has an average duration of twenty minutes, being interrupted to clarify doubts and questions made by the companion.

During the intervention, it will be agreed with the companion not to make the manual available to other people, clarifying the justifications for this fact.
The selection of the sample will follow the following inclusion criteria: be accompanying the choice of the woman patient; be accompanying nulliparas; have completed at least the fourth year of elementary school (level of education compatible with the readability index of Flash calculated for the manual evaluated here); as well as puerperal women who have companions with this profile; will also include all the puerperas who had, during the birthing process, the presence of companions who participated in this research in both groups."	"The exclusion criteria will be: to present a state of physical or mental health compromised in order to make data collection unfeasible; have previous experience of witnessing delivery as a companion; participate in another intervention in the institution (Ex.:Roda de Conversa)

The criteria for discontinuity will be: to accompany a parturient referred for cesarean section; give up participating in the study after the start of the collection; give up or be unable to follow labor / delivery; change of address and / or telephone that makes the contact unfeasible after the birth, if the only way to establish communication with the participant is by telephone."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-9d8xr6	Benefits of aquatic physiotherapy in the health of the elderly	Data analysis completed	Intervention	2017-01-30	<NULL>	<NULL>	1174	Contribution of aquatic physiotherapy in the health of the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-29	Franciele Aparecida Amaral	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-9d8xr6	<NULL>	Elderly people aged 60 to 80 years; Of both genders; Who frequent the HIPERDIA group; That present independent gait and independence in activities of daily living (ADLs). Individuals should be aware of the research and that they accept the conditions established in the work and specified in the Informed Consent Term (ICT).	Elderly without dermatological medical certificate favorable to aquatic physiotherapy; Urinary or fecal incontinence; Presence of open wounds, probes, tracheostomies, infectious cutaneous diseases, neurological diseases, infectious diseases, renal insufficiency, heart disease without cardiologist&apos;s authorization, severe pneumopathies, uncontrolled hypertension or above 160 X100 mmhg, vascular thrombi, Severe cognitive and auditory deficits, severe osteomioarticular pathologies, physical deficiency; Participation in other physical activities or even Aquatic Physiotherapy less than 6 months or that are in another type of moderate physical activity supervised with two or more times in the week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-44g6qp	Benefits of different ways of practicing bodybuilding	Recruitment completed	Intervention	2019-08-29	<NULL>	<NULL>	2932	"Acute and chronic adaptations of different resistance training protocols and
concurrent"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-15	Faculdade de Nutrição-Universidade Federal de Goias	Faculdade de Nutrição-Universidade Federal de Goias	https://ensaiosclinicos.gov.br/rg/RBR-44g6qp	<NULL>	Individual from 60 to 85 years old; both sexes; untrained	Acute or terminal musculoskeletal disease; cardiovascular disease; unstable cardiovascular condition; recent history of acute myocardial infarction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-633rr3r	Benefits of Electrostimulation in Facial Pain	Recruiting	Intervention	2023-02-10	<NULL>	<NULL>	5898	Effects of Transcutaneous Electrical Nerve Stimulation in the treatment of patients with Temporomandibular Disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-10	Centro de Ciências da Saúde da Universidade Federal de Santa Catarina	Centro de Ciências da Saúde da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-633rr3r	<NULL>	diagnosis of muscular or mixed temporomandibular disorders; adults between 18 and 45 years old; body mass index from 18.5 to 29 points.	diagnosis of temporomandibular joint dysfunction; more than three missing teeth or two missing teeth in occlusion pairs; use of muscle relaxants; neurological impairment that prevents comprehension of tasks; has performed; be below the body mass index.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-26gmvg	Benefits of Epidural block in pain control after liver embolization, compared to venous analgesia	Not yet recruiting	Intervention	2018-08-01	<NULL>	<NULL>	2081	Randomized clinical trial on the effectiveness and benefits of Peridural blocking in the control of Post-embolization syndrome, compared to venous analgesia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Fundação Antônio Prudente	Fundação Antônio Prudente	https://ensaiosclinicos.gov.br/rg/RBR-26gmvg	<NULL>	Patients of both genders; 18 years or more; submitted to hepatic embolization; consent to the free and informed consent form.	"Absolute contraindications and related to epidural block; patients who remain intubated or are reintubated in the postoperative period; present epidural block failure;
with dialysis renal insufficiency or severe hepatic impairment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-9kr2jb	Benefits of Functional Training for the elderly	Recruitment completed	Intervention	2018-08-14	<NULL>	<NULL>	2118	The effect of Functional Training on physical fitness, functional capacity and lumbar pain reports in older women: clinical testing	<NULL>	0, non-randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-9kr2jb	<NULL>	Healthy elderly; aged 60-69 years, women; not physical exercise; autonomous	Bracing or prosthesis holders; difficulties for the cognitive domain; practitioner of physical exercises; not assiduous during functional training intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-8c7267	Benefits of functional training in women with knee pain.	Data analysis completed	Intervention	2017-09-15	<NULL>	<NULL>	4268	Effect of neuromuscular training and strengthening of the lower limbs musculature in women with Patellofemoral Pain Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-28	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8c7267	<NULL>	"Subjects must sign the Free and Informed Consent Form before starting the study activities; Aged between 18 and 30 years; 
Active womens, who perform any physical activity up to twice a week; Presence of anterior or retropatellar pain in the knee for at least the last 3 months in two or more of the following activities: running, walking, jumping, climbing and/or descending stairs while remaining seated or kneeling for an extended period of time, Squatting position during the isometric extension of the knee with 60º of flexion, and/or during palpation of the medial or lateral facet of the patella; Presence of dynamic valgus during the unipodal squatting."	Will be excluded, individuals submitted to recent physiotherapeutic treatment; With history of knee surgery; Patellar instability; Ankle or hip injuries; Meniscal or ligament injury; Joint swelling of the knee, or any other specific knee change; Tendinitis in the lower extremity; Low back pain; Pain in the sacroiliac joints; pregnancy; Presence of any neurological disorders / disorders that compromise the understanding of the procedure, or that affect motor control; Any cardiovascular changes and rheumatic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-25kmmdk	Benefits of Gestational Diabetes Education for Pregnant Women	Recruiting	Observational	2024-05-02	<NULL>	<NULL>	6984	Effectiveness of using a digital booklet for health education about gestational diabetes	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Católica de Santos	Universidade Católica de Santos	https://ensaiosclinicos.gov.br/rg/RBR-25kmmdk	<NULL>	Being female; be 18 years of age or older; reside in Brazilian territory; be pregnant; declare to know how to read and type; agree to the Free and Informed Consent Form	Being male; be a minor; do not reside in Brazilian territory; not being pregnant; not have literacy; not agreeing to the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-95mw4qm	Benefits of Health Education using an Educational Booklet for Hemodialysis patients	Recruiting	Intervention	2025-07-21	<NULL>	<NULL>	8145	Effectiveness of an Educational Booklet in promoting self-care among Hemodialysis patients with Arteriovenous Fistula	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-24	Universidade Estadual do Ceará	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-95mw4qm	<NULL>	to be 18 or older; both sexes; followed up in the Hemodialysis service with via permanent vascular access of the Arteriovenous Fistula type; Hemodialysis started at least four weeks ago; be able to read and understand the booklet	incapacitating Mental Illness; being homeless; living in a collective shelter or deprived of liberty; having a non-functioning Arteriovenous Fistula	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-45zfr4b	Benefits of innovative treatment for women with fibromyalgia: a procedure to follow	Data analysis completed	Intervention	2020-12-18	<NULL>	<NULL>	4436	Benefits of repetitive intravenous lidocaine infusions in patients with fibromyalgia syndrome and the relationship with inflammatory biomarkers: a procedure to follow	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-05-07	Universidade Federal de Sergipe	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-45zfr4b	<NULL>	Female; between 35 and 65 years old, previously diagnosed with fibromyalgia by an experienced anesthesiologist according to the criteria of the American College of Rheumatology, in the chronic pain outpatient clinic of the University Hospital of the Federal University of Sergipe.	Hypersensitivity to the tested drugs; Recent injury or trauma; diagnosis of epilepsy, psychiatric disorders,rheumatic disorders, moderate or severe neuromuscular disorders, hypothyroidism or hyperthyroidism, arthropathy, infectious disease, another chronic pain syndrome, neoplasms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:12
RBR-25dm9p	Benefits of light and shock in the head more walking on a treadmill walking in improving stroke sequelae.	Not yet recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1518	Effects of the combination of photobiomodulation, transcranial direct current stimulation and treadmill training on functional mobility in stroke survivors: Protocol for a randomized, sham-controlled, double-blind clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-25dm9p	<NULL>	diagnosis of stroke six months to five years prior to study; Hemiparesis secondary to single unilateral event; Independent gait; Age 45 to 60 years; performance of the functional tests and Physical Fitness; incremental cardiopulmonary exercise test; consent to their participation in the study by signing the Informed Consent Form	Joint pain in lower limbs that impairs function;Obesity of sufficient severity to limit gait training; Cardiovascular condition or cognitive impairment that renders the tests impossible; History of seizures; History of head trauma; Previous head surgery; metal implants on the head.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-3rqcxqd	Benefits of Morphine gel for pain reduction in patients with Cancer Wounds	Not yet recruiting	Intervention	2022-10-13	<NULL>	<NULL>	5660	Effectiveness of Topical Morphine use in patients with painful Neoplastic Wounds in the breast and head and neck: double blind randomized clinical trial - MorphineGel	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-11-01	Escola de Enfermagem Aurora de Afonso Costa	Instituto Nacional de Câncer José Alencar Gomes da Silva - Hospital do Câncer IV	https://ensaiosclinicos.gov.br/rg/RBR-3rqcxqd	<NULL>	Patient enrolled in the unit; primary or metastatic breast or head and neck disease of any histological type; malignant neoplastic wound with stage II or greater; 18 years of age or older; karnofsky performance status greater than or equal to 30%; have at least 3 on the pain intensity scale; admission time of 48 hours or more; using systemic morphine	Fistulated wound; wound with extensive coagulation necrosis (more than 50% of the wound area); wound with exudation greater than 1 (pressure ulcer scale for healing); wound with bleeding greater than 1 (validated intraoperative bleeding scale); radiotherapy in progress in the wound	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-4k7dmm8	Benefits of Neuropsychomotor Intervention with Dance Therapy on Stress Management in adults and its relationship with levels of Cortisol and Brain-Derived Neurotrophic Factor	Recruitment completed	Intervention	2023-12-14	<NULL>	<NULL>	6657	Effects of Neuropsychomotor Intervention with Dance Therapy on Stress management and its relationship with levels of Cortisol and Brain-Derived Neurotrophic Factor in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-25	Universidade Federal de Santa Catarina	Centro de Desenvolvimento Neuropsicomotor Ana Malheiros Ltda	https://ensaiosclinicos.gov.br/rg/RBR-4k7dmm8	<NULL>	Adults aged between 20 and 59 years ; who are classified as having stress levels above normal (stressed) according to the questionnaires (DASS-21 and/or PSS-10); of both sexes;  who reside in the city of Florianópolis or metropolitan region	Adults  under age range is outside of that proposed in the inclusion criteria; if they are not classified as having stress levels above normal (stressed) according to the questionnaires (DASS-21/eor PSS-10); adults who do not live in Florianópolis or the metropolitan region; adults with a diagnosis that prevents participation in the research (people with severe uncorrected hearing and/or visual impairment); with suspected or confirmed pregnancy; who are using any type of medication pharmacological treatment that may influence the variables evaluated (for example, antidepressants, anxiolytics, corticosteroids, statins, beta-blockers, anti-inflammatories, stimulants, etc.); adults diagnosed with some type of mental disorder, cardiovascular diseases, diabetes mellitus (DM), type 2 diabetes mellitus (DM2), Cushing&apos;s syndrome and Addison&apos;s disease; who regularly participate or have attended dance therapy programs in the last three month; smokers; research participants who do not carry out 75% of the planned interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-9wkvm5b	Benefits of non-invasive pulmonary ventilation soon after tube removal in the postoperative period of heart surgery	Data analysis completed	Intervention	2021-12-07	<NULL>	<NULL>	5083	Benefits of Non-Invasive Ventilation immediately after extubation in the Postoperative period of Cardiac Surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Faculdade Nobre de Feira de Santana	Faculdade Nobre de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-9wkvm5b	<NULL>	This study included patients of both sexes; aged 18 years or older; who underwent to coronary artery bypass grafting with median sternotomy and cardiopulmonary bypass.	Patients with hemodynamic instability before noninvasive ventilation; who were not cooperative or who had contraindications for the use of noninvasive ventilation; chronic pulmonary disease; absence of blood gas analysis in some of the study phases; physical limitations that compromised the performance of functional tests were excluded; difficulty understanding to perform the applied tests; surgical reintervention; more than 24 hours in invasive mechanical ventilation; patients who refused to sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-83h7hfm	Benefits of Nutrition and Physical Activity for the health of people with Kidney Issues	Recruiting	Observational	2025-06-26	<NULL>	<NULL>	8067	Impact of Nutrition and Exercise on Microbiota, Uremic Toxins and quality of Life in patients with Chronic Kidney Disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-11	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-83h7hfm	<NULL>	Volunteers diagnosed with chronic kidney disease; age minimum eighteen and age maximum sixty five years; physically inactive.	Smoker volunteers; diagnoses of cardic; gastrointestinal; hepatic; pulmonary; neurological; psychiatric; hematological or metabolic autoimmune diseases; diagnosis of sleep disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-7tgfwmk	Benefits of peppermint oil in upper digestive endoscopies	Not yet recruiting	Intervention	2021-05-29	<NULL>	<NULL>	4701	Use of L-menthol solution as an esophageal antispasmodic in Upper Digestive Endoscopy: pilot project	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7tgfwmk	<NULL>	Patients over 18 and under 65;Signed consent form; No known esophageal pathologies; Undergoing diagnostic EDA under conscious sedation	Under 18 or over 65 years old; Refusal to sign the consent form; previously known esophageal pathologies; Undergoing therapeutic examination; Examination performed without sedation or under general anesthesia; Need for the use of scopolamine during the performance of the diagnostic examination before the evaluation for the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:34
RBR-9hk6pgz	Benefits of Physical Exercise for older adults with Obstructive Sleep Apnea	Not yet recruiting	Intervention	2023-05-04	<NULL>	<NULL>	6052	Obstructive Sleep Apnea treated with Exercise and Inspiratory Muscle Training: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9hk6pgz	<NULL>	Age between 60 and 79 years; both genders; moderate to severe Obstructive Sleep Apnea, with an apnea-hypopnea index greater than 15 events per hour; no history of previous or current Obstructive Sleep Apnea treatment; and no other sleep disturbance than Obstructive Sleep Apnea	Use sleeping medications; have engaged in physical exercise within the past six months; have contraindications (cardiovascular, respiratory, musculoskeletal, or neurological) for exercise; or have cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-43sjz7	Benefits of physical therapy and cognitive training in the non-motor symptoms (sleep and cognition) in patients with Parkinson&apos;s disease	Recruiting	Intervention	2016-02-26	<NULL>	<NULL>	723	Effectiveness of physical therapy associated to cognitive training in the improvement of non-motor symptoms in patients with Parkinson´s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-43sjz7	<NULL>	"Medical diagnosis of Parkinson&apos;s disease, according to the criteria of the London Brain Bank (Uk Parkinson&apos;s Disease Society Brain Bank Clinical Diagnostic Criteria)
Individuals over 50 years. Not  institutionalized. Mini Mental score that does not characterize cognitive impairment. Hohen Yahr between 1.5 and 3.0. Which accept to participate of the project and sign the consent term according to the criteria of the Ethics Committee of the Universidade Estadual de Londrina, according to the parecer 466/2912 (CNS)."	Individuals who perform another therapeutic treatment beyond medication, that has change in medication during the study or those with associated diseases, such as neurological disorders, severe heart disease, amputations, cognitive or understanding deficits. Change in the stabilization of the antiparkinsonian medication doses throughout the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-10mgmj53	Benefits of pilates on the health of women in menopause	Recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7087	Effects of mat pilates training on cardiovascular, anthropometric, and strength responses in women in menopause	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-02	Universidade Federal de Uberlândia	Programa de Pós Graduação em Ciencias da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-10mgmj53	<NULL>	Women aged between 40 and 70 years old; present a pre-existing medical certificate proving that they are able to engage in physical activities; do not have physical problems or cardiovascular complications that prevent the practice of physical exercises; do not have a history of stroke or acute myocardial infarction; are non-smokers; do not have a diagnosis of diabetes mellitus; do not have renal pathologies; do not use medications that interfere with lipid metabolism	Training attendance frequency lower than 85%; failure to perform tests in the pre and post intervention periods; injuries of any nature related or unrelated to the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-89kchg	Benefits of traditional, functional and calisthenic training in physical fitness, cardiovascular health and quality of life of the elderly	Data analysis completed	Intervention	2019-02-05	<NULL>	<NULL>	2467	Influence of Traditional, Functional and Calisthenic Training on Physical Fitness, Cardiovascular Health and Quality of Life in Older Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-29	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-89kchg	<NULL>	Be physically independent; Be 60 years of age or older; Do not present medical history of heart disease, musculoskeletal disorders, diabetes, uncontrolled hypertension or any other dysfunction that restricts the practice of high intensity physical exercises; Do not use hormone therapy medications, lipid-lowering agents, hypoglycemic agents and anti-inflammatories	Regular participation in systematic exercise programs in the three months prior to the present study; Presence of uncontrolled cardiovascular and musculoskeletal diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-7xvpbw3	Benefits of using video calls compared to using a cell phone app on the rate of smoking cessation, post-stop symptoms and levels of Anxiety and Depression	Not yet recruiting	Intervention	2021-02-22	<NULL>	<NULL>	4554	Efficacy of synchronous call center compared to the use of cell phone application in Smoking Cessation Rate, Withdrawal Syndrome and Anxiety and Depression level	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade do Oeste Paulista (UNOESTE)	Universidade do Oeste Paulista (UNOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7xvpbw3	<NULL>	The study will include individuals over 18 years of age, of both sexes, smokers for at least 1 year, including smokers of tobacco derivatives such as string cigarettes, cigars, cigarillos and water pipes (hookahs), without reports of severe psychiatric morbidities. , such as schizophrenia or bipolarity previously diagnosed, literate and able cognitively to answer the evaluations and questionnaires of the study.	Individuals with an IOS smartphone that are incompatible with the app and who abandon treatment during the study will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-5wvg53s	Benzbromarone medication treatment to improve Respiratory Health and Quality of Life for patients with Cystic Fibrosis	Not yet recruiting	Intervention	2021-01-05	<NULL>	<NULL>	4460	Benzbromarone for the treatment of Cystic Fibrosis	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2021-05-01	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	https://ensaiosclinicos.gov.br/rg/RBR-5wvg53s	<NULL>	Confirmed diagnosis of cystic fibrosis based on the following criteria: Positive sweat chloride 60 mEq liter; A genotype with two pathogenic CF mutations identified; FEV1 with values between 40% and 90% of that predicted in spirometry; Female patients who deny sexarche	"Beginning of any new therapy, for example, ibuprofen, Pulmozyme, hypertonic saline, azithromycin, TOBI, Cayston within four weeks before the start of the study; Episode of pulmonary exacerbation in the period of four weeks before the start of the study; Significant hemoptysis in the period of four weeks prior to the start of the study, 5 mL of blood in a coughing episode or 30 mL of blood in a 24 hour period; Abnormal liver function, TGO and TGP at levels three times above the reference values;
Abnormal renal function, glomerular filtration rate, GFR, below 60mL  min and 1.73m2 according to the calculation estimated by the Schwartz formula; Use of an experimental drug within four weeks before the start of the study; Use of intravenous or oral steroids within four weeks before the start of the study; Patients submitted to the list of lung transplant and or transplanted."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-633mkf7	Best Pain Block with Ultrasound in kids: comparing techniques for Abdominal Surgeries	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8299	Comparative study between Ultrasound-Guided Quadratus Lumborum Blocks, TAP Blocks, and Sacral Epidural Anesthesia in pediatric patients undergoign Abdominal Wall Surgery: a randomized double-blind study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-10-01	Hospital São Domingos	Hospital Infantil Dr. Juvêncio Matos	https://ensaiosclinicos.gov.br/rg/RBR-633mkf7	<NULL>	Pediatric patients undergoing elective unilateral or bilateral abdominal wall surgery; both genders; age between 1 and 8 years; American Society of Anesthesiologists (ASA) physical status classification I or II	Pediatric patients presenting American Society of Anesthesiologists (ASA) physical status classification III or IV; skin redness or infection at the needle injection site; diagnosis of coagulopathy; liver disease; motor developmental delay; known allergy to local anesthetics; parental refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-7j4cc2k	BETERC: Brazilian epidemiological trial evaluation rotator cuff	Not yet recruiting	Observational	2022-09-19	<NULL>	<NULL>	5615	Brazilian cohort of patients undergoing rotator cuff repair	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7j4cc2k	<NULL>	Adult patients of both male and female; aged over 18 years; who have a rotator cuff injury with indication for surgical repair confirmed by the exam ultrasound or magnetic resonance imaging; with a record of consent to participate in the study by signing the free and informed consent form.	Patients who refuse to register their consent by signing the term of informed consent; with incomplete documentation; who do not have an magnetic resonance images (MRI) preoperative magnetic field capable of confirming their injuries and those who lose the postoperative follow-up. Those with a history of fracture in the shoulder girdle; previous shoulder surgeries; local neoplasia or undergoing surgical treatment for re-rupture of the rotator cuff will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3mvbsk	Better living: impacts of Therapy For Exercise in the health of elderly	Recruiting	Intervention	2019-10-30	<NULL>	<NULL>	3156	Effects of the volume and intensity of the Physical Exercise, comparing the complexity of the Motor Task on the cognitive capacity of elderly persons with Mild Cognitive Impairment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-18	Universidade do Oeste de Santa Catarina - Unoesc	Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-3mvbsk	<NULL>	Individuals aged 60 years and over; with mild cognitive impairment or early dementia; medical health service monitoring; who voluntarily agree to participate in the study will be considered eligible.	Exclusion criteria involve elderly patients with cardiovascular impairments; musculoskeletal or visuospatial limitations that may contraindicate or present discomfort to the exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-2q4ht7r	Bicalutamide associated with oral Minoxidil for the treatment of female baldness	Data analysis completed	Intervention	2024-07-01	<NULL>	<NULL>	7114	Efficacy and safety of Bicalutamide 25 mg associated with Minoxidil 1 mg oral versus Minoxidil 1 mg oral for treating female pattern Alopecia: double-blind and randomized clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-09-12	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2q4ht7r	<NULL>	Patients diagnosed with Female Pattern Alopecia (stages II, III, IV and V of the Sinclair Scale); patients with a minimum age of 18 years and a maximum age of 60 years; female patients	Any type of previous alopecia treatment in the past 4 months; patients with diagnosis of Systemic Arterial Hypertension; cardiopaths patients; hepatophats patients; nephropats patients; patients with any other cause of hair loss besides Female Pattern Hair Loss; patients with pregnancy intention in the next 12 months; patients in fertile age that wont agree in the use of secure contraceptive methods; patients who, during the clinical trial, present an increase in liver enzymes greater than two and a half times the upper limit of normality	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-5ypjzb	Bilateral arms function after bilateral training in individuals with severe hemiparesis: a randomised clinical trial	recruiting	Intervention	2011-07-31	<NULL>	<NULL>	19	Bilateral upper limbs function after bilateral training in individuals with severe hemiparesis: a randomised clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade do Estado de Santa Catarina	Nayara Correa Farias	https://ensaiosclinicos.gov.br/rg/RBR-5ypjzb	<NULL>	"Chronic Hemiparesis (at least six months after stroke);  Age over 21 years;
  Severe impairment in upper limb (Fugl-Meyer in the less 30/66);  Understanding simple order"	Patients with other associated neurological diagnosis;  Subjects with orthopedic injuries in the upper bounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-9fzpr9h	Bilateral flexible ureteroscopy for kidney stones	Recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8840	Bilateral flexible ureteroscopy for kidney stones using flexible and navigable suction ureteral access sheath (FANS): a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-10	hospital das clinicas da faculdade de medicina da universidade de são paulo	<NULL>	<NULL>	<NULL>	Patients over 18 years of age; Both genders; Stones located in both kidneys with indication for flexible ureterorenolithotripsy; Maximum volume of 8,000 mm3 of kidney stones identified on CT scan	Concomitant urological pathologies, including anatomical malformations; Psychiatric illnesses; Chronic pelvic pain syndrome; Inability to continue outpatient follow-up; Pregnant women; Patients with active urinary tract infection; Patients who are not clinically fit for general anesthesia	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-8kqnzkt	Bioactive composite resin in gingival recession treatment: Randomized clinical study	Recruitment completed	Intervention	2025-10-31	<NULL>	<NULL>	8479	Evaluation of a bioactive composite resin in the surgical/restorative treatment of gingival recessions in non-carious cervical lesions: A randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade de Guarulhos (UnG)	<NULL>	<NULL>	<NULL>	Systemically healthy individuals; age between 18 and 50 years; at least two teeth with gingival recessions Recession Type 1 or Recession Type 2 (Miller Class I or II); presence of non-carious cervical lesions associated with gingival recessions located in upper canines or premolars; periodontally healthy patients with less than 10% of sites presenting bleeding on probing and probing depth less than or equal to 3 mm	Smokers; pregnant or lactating women; individuals with diabetes or periodontal disease with more than 10% of sites showing bleeding on probing; teeth positioned buccally outside the alveolar envelope; continuous use of anti-inflammatory drugs or medications that interfere with tissue response such as anticoagulants, antiplatelet agents, phenytoin and calcium channel blockers; patients allergic to iodine or with known hypersensitivity to the materials used; contraindications for periodontal surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:29
RBR-5ggyf5	Biocompatibility of adhesive restorative materials on human teeth	Recruitment completed	Intervention	2018-10-10	<NULL>	<NULL>	2278	Immunohistochemical Expression of Metalloproteinases and Inflammatory Proteins after the use of adhesive restorative materials in human teeth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Faculdade de Odontologia de Pernambuco	Faculdade de Odontologia de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5ggyf5	<NULL>	Healthy volunteers; Both genders; non smokers; Age between 18 and 40 years; Who have fully erupted third molar teeth; Without caries; vital; With complete rhizogenesis; and adequate oral health	Patients who do not have third molar teeth or are not indicated for exodontia; Carriers of systemic and / or oral alterations; Teeth that present restorations on any surface or negative response to the thermal test of cold pulp sensitivity; Impossibility of absolute isolation; Teeth with root resorption	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-9g4yp2	Bioelectrical impendance analysis parameters evaluation as severity markers in patients admitted in intensive care unit.	Recruiting	Observational	2013-12-10	<NULL>	<NULL>	293	Bioelectrical impendance analysis parameters evaluation as severity biomarkers in the critically ill patient	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-02-15	Instituto Fernandes Figueira - Fundação Oswaldo Cruz	Vice-presidência de pesquisa e laboratórios de referência - Programa de desenvolvimento tecnológico em saúde pública (PDTSP)	https://ensaiosclinicos.gov.br/rg/RBR-9g4yp2	<NULL>	All patients aged 1 month to 6 years-old admitted to the pediatric intensive care unit that do not presented on admission with the outcomes studied (multiple organs dysfunction &gt; or equal 4 or septic shock).	Children weighing less than 3kg on admission in the pediatric intensive care unit; impossibility to perform bioimpedance measurement in the first 24h of hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-7xds2v	Biofeedback in improving diabetic heart health.	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1616	Cardiovascular biofeedback in autonomic neuropathy in individuals with Diabetes Mellitus type 2.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7xds2v	<NULL>	The following may be included in the study: individuals with Type 2 Diabetes mellitus of both sexes; aged 50-75 years; sedentary; no history of neurological diseases; muscular or rheumatic diseases outside the etiology of diabetes and that reside in the region of Greater Recife.	The exclusion criteria applied will be: presence of unstable angina; pacemaker; severe pneumopathies or other limiting diseases such as neoplasms; valvulopathies; advanced dementia; aortic aneurysm; renal insufficiency and decompensated heart failure. Individuals with orthopedic and / or neurological diseases that may not be able to perform the cardiopulmonary exercise test will also be excluded; besides the patients who present intellectual deficiencies that restrict them to answer the questionnaires and understand the proposed games.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-10w3x7r3	Bioimpedance, respiratory health and inflammation in adults with Cystic Fibrosis: a prospective observational study	Not yet recruiting	Observational	2023-10-31	<NULL>	<NULL>	6556	Phase angle of bioelectrical impedance, lung function, and systemic inflammation in adults with Cystic Fibrosis: a prospective observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-20	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-10w3x7r3	<NULL>	Adults of both genders; aged 18 to 59; with Cystic Fibrosis; under the care of a specialized outpatient clinic at a tertiary hospital	Comorbidities characterized by systemic low-grade chronic inflammation or malabsorptive syndromes, except for those secondary to Cystic Fibrosis; malignant neoplasm; edema; chronic kidney disease with glomerular filtration rate less than 60 mg/dL; end-stage organ failure; amputated limbs; gastric or intestinal resections; implanted cardiac devices; chronic use of oral immunosuppressants or anti-inflammatory drugs; initiation of diuretic use or dose modification 3 months prior to recruitment; pulmonary exacerbations within 3 months of recruitment; ethical restrictions that prevent proper consent for study participation; women who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5mtk9d8	Biological and Empathy effects after Communication Training in health professionals	Recruiting	Intervention	2024-02-08	<NULL>	<NULL>	6779	Neurobiological Modulation and Empathy in Improving Health Communication Skills	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5mtk9d8	<NULL>	Medical students aged between 18 and 45 will be included in the sample in any period of training. All participants must sign the Free and Informed Consent Form – TCLE	Having participated in some interpersonal communication training or similar, individuals who attended less than 75% of the interventions during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-6y4ghx	Biological and psychological correlates of mental illnesses	Recruiting	Intervention	2015-04-14	<NULL>	<NULL>	446	Biological and neurocognitive markers in neuropsychiatry	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-23	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6y4ghx	<NULL>	Fifty patients with a diagnosis of obsessive-compulsive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); aged between 18 and 50 years; with at least primary school; able to use computers; under regular pharmacological treatment for at least 3 months.	Any condition that hinders the smooth progress of the procedure as psychiatric comorbidities that impedes the assessment with the dotprobe task or with symptom severity scales; cardiac pacemakers and some brands of cerebral aneurysm clips; cochlear implants and neurostimulators; firearm projectiles and other metal fragments depending on the location in the body.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-233bct	Biomarkers and clinical scores in critically ill patients at the emergency department	Recruiting	Observational	2020-02-10	<NULL>	<NULL>	3465	Biomarkers and clinical scores in critically ill patients at the emergency department	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-08-05	Fundação de Amparo a Pesquisa do Estado de São Paulo	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-233bct	<NULL>	Volunteers; Admitted to the Emergency Department for any acute illness; Patients hospitalized for less than 24 hours; Patients over 65 years	Hospitalization for exclusive palliative care or end-of-life care; Expected hospital stay less than 48 hours; Hospitalization for less than 30 days; Refusal of the patient or his representative to sign an informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-7jyccp	"Biomaterials for preventing sensibility after
home bleaching"	Not yet recruiting	Intervention	2015-07-19	<NULL>	<NULL>	551	Randomized clinical trial study of effect of potassium nitrate and strontium chloride  associated to the bleaching home treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de odontologia da Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7jyccp	<NULL>	"60 people aged between 18 and 26 years;
any genders? good health; no-snmoking;
pH and salivary flow within normal limits;
healthy teeth and initial color A2 or darker
according to the Vita scale."	"Having received previous dental bleaching;
restorations on the anterior teeth; pregnant
or nursing women; having teeth darkened by
tetracycline, fluorosis or endodontic
treatment; patients with teeth grinding;
having noncarious
cervical lesion; and
dentin hypersensitivity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-6qbztf	Biomaterials for preventing sensibility after home bleaching	Not yet recruiting	Intervention	2015-07-09	<NULL>	<NULL>	540	"Randomized clinical trial of the nano-hydroxyapatite and arginine effect for the 
dentin sensibility prevention after bleaching home treatment"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de odontologia da Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6qbztf	<NULL>	"60 people aged between 18 and 26 years;
any genders; good health; non-moking;
pH and salivary flow within normal limits;
healthy teeth and initial color A2 or darker
according to the Vita scale."	"Having received previous dental bleaching;
restorations on the anterior teeth; pregnant
or nursing women; having teeth darkened by
tetracycline, fluorosis or endodontic 
treatment; patients with teeth grinding;
having noncarious
cervical lesion; and
dentin hypersensitivity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-55kzbn	Biomechanical analysis in individuals with anterior knee pain and its treatment	Not yet recruiting	Intervention	2015-07-27	<NULL>	<NULL>	558	Morphological, neurofunctional, kinetics and kinematics analysis in individuals with patellofemoral pain syndrome and its treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-55kzbn	<NULL>	It will be included 40 participants with unilateral or bilateral patellofemoral pain; aged between 18 and 35 years; report onset of symptoms insidiously not related to a traumatic event; should have pain (at least 3 of 10 points according visual analogue scale) in retropatellar or peripatellar region at least three of the following functional activities: up or down stairs; run; kneeling; squat; stand for long periods sitting; jumping; isometric contraction of the quadriceps and palpation of the lateral and / or medial side of the patella; and the presence of pain for at least two months. Also; it will be included 40 participants without pain; aged between 18 and 35 years and they should present any history of injury or pain in the knees.	Both groups should not have history of surgery on knees; history of injury or pain in the hip; patellar instability; pain on palpation of the patellar tendon; iliotibial band or tendons of goose foot; signs or symptoms of meniscal or ligament injuries of the knee; presence of Osgood-Schlatter disease or Sinding-Larsen-Johansson syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-6whk9jy	Biomechanical aspects of orthodontic treatment with Aligners: a randomized clinical trial	Recruiting	Intervention	2024-03-11	<NULL>	<NULL>	6845	Biomechanical aspects of orthodontic treatment with In-house Aligners: a randomized clinical trial	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Pontifícia Universidade Católica de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6whk9jy	<NULL>	Volunteers who have or have not received previous preventive orthodontic treatment carried out at PUC Minas and need for the corrective orthodontic phase to complete the case; need for corrective orthodontic treatment with mild to moderate discrepancies; permanent denture completely erupted, with the permanent second molars being in the mouth or not; absence of systemic diseases or regular use of medications that could interfere with normal growth and/or orthodontic movement	Patients who do not have permanent dentures; those with severe malocclusion and systemic diseases that may influence orthodontic treatment will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-56hhk6	Biomechanical changes of the ankle and foot and the professor&apos;s feet pain	Recruitment completed	Intervention	2020-03-25	<NULL>	<NULL>	3660	Relationship of biomechanical changes in the ankle and foot with the incidence of plantar Fasciitis in professors	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2019-07-01	UNICESUMAR	UNICESUMAR	https://ensaiosclinicos.gov.br/rg/RBR-56hhk6	<NULL>	The inclusion criteria will be individuals who work at the institution on a labor basis; with due registration in the work card; and who have pain in the plantar region of the foot for at least seven days.	The exclusion criteria will be individuals who are outside the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-2qknq6d	Biomolecular and histopathological evaluation of fat and muscle tissue in patients with obstructive sleep apnea	Recruiting	Intervention	2021-02-11	<NULL>	<NULL>	4551	Evaluation of autophagic flow in response to cell stress in musculoskeletal and adipose tissues in obese patients with obstructive sleep apnea	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-28	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2qknq6d	<NULL>	Patients diagnosed with obesity; indication for bariatric surgery; eutrophic patients with indication for cholecystectomy; aged over 18 and under 50 years old; both sexes; with body mass index greater than or equal to 40 or 35 with compensated comorbidities; BMI between 20 and 29.9 for the eutrophic control group.	Individuals who present the usual report of sleep time less 4 hours per night; individuals with insomnia; shift workers; chronic alcoholism; use of neuroleptic and hypnotic drugs; psychiatric diseases; individuals with locomotion; individuals using drugs that inhibit autophagy such as colchicine and bafilomycin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-6gmwrdh	Biopsies of pancreatic lesions for better diagnostic evaluation.	Not yet recruiting	Intervention	2020-11-26	<NULL>	<NULL>	4387	22G fine aspiration needle vs 22G fine biopsy needle in the diagnostic rate of solid pancreatic lesions with suspected malignancy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Faculdade de medicina da universidade de são paulo	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-6gmwrdh	<NULL>	"Patients with solid pancreatic lesion diagnosed through imaging method who attended the Endoscopy Department of Hospital das Clínicas of the School of Medicine of University of São Paulo (HC-FMUSP), Digestive endoscopy unit of Fortaleza General Hospital, or in the Digestive endoscopy unit of Hospital das Clínicas of Ribeirão Preto.
Age between 18 and 70 years; Signed the Informed Consent Form (ICF)"	No lesion identified through EUS; Duodenal papilla tumor; Unavailability of needles at the hospital at the time of the procedure; Presence of large vein or biliary stent in the puncture path; Contraindication for endoscopic puncture of the lesion; Current use of anticoagulants or known change in coagulation; Suspended or incomplete procedures; Participation in another clinical protocol that may affect the patient safety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-9r7yhzk	Biopsychosocial perspective of the home environment of children born with Gastroschisis: observational study	Data analysis completed	Observational	2025-07-11	<NULL>	<NULL>	8119	Evaluation of physical growth, body composition, and neuropsychomotor development of patients with Gastroschisis over the first two years of life: cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Instituto Fernandes Figueira - IFF/ FIOCRUZ	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9r7yhzk	<NULL>	Children born with simple or complex gastroschisis; both sexes; between 3 and 4 months of corrected chronological age	Children with genetic syndromes; other congenital malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-63hk5w	Biotin 2.5mg oral and Minoxidil 5% increase the speed of growth of the nails of the hands in healthy adults.	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2056	Evaluation of nail growth: comparison between Biotin and topical Minoxidil	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-22	UNESP - Universidade Estadual Paulista	UNESP - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-63hk5w	<NULL>	Healthy men and women; 18 to 65 years	Pregnant; infants; active smokers; active alcoholics;cutaneous or systemic pathology influencing nail growth; drugs established in the literature that alter nail growth; allergy to minoxidil or biotin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-69qq9p	Biotin in the treatment of female hair loss	Not yet recruiting	Intervention	2020-01-29	<NULL>	<NULL>	3420	A 24-week randomized, prospective, triple-blinded, placebo-controlled trial investigating the efficacy of 10 mg biotin in the treatment of chronic effluvium telogen in women	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-07-01	Paulo Ramos	Faculdade Medicina da Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-69qq9p	<NULL>	Inclusion criteria: women between the ages of 18 and 65 who complain of increased hair loss for more than six months; daily loss of yarn equivalent to at least level 5 of the Sinclair drop scale	Clinical or dermatoscopic signs of alopecia areata, trichotillomania or cicatricial alopecias; anemia (hemoglobin less than 11 mg / dl), thyroid changes (TSH&gt; 4.0 or &lt;0.3 um/L or T4l&gt; 1.5 or &lt;0.7 ng/dl); history of any treatment for hair loss in the last 3 months; surgery, pregnancy, febrile infectious disease or suspension of contraceptive use in the last 4 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-8dzrvjg	Biperiden effect to reduce the desire to use cocaine/crack	Data analysis completed	Intervention	2022-01-06	<NULL>	<NULL>	5135	Effects of biperiden (muscarinic antagonist) on cocaine/crack dependence	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-06-09	Universidade Federal de São Paulo	Secretaria Nacional de Cuidados e Prevenção às Drogas - SENAPRED	https://ensaiosclinicos.gov.br/rg/RBR-8dzrvjg	<NULL>	male; age between 18 and 70 years; severe disorder related to the use of cocaine or crack according to the Diagnostic and Statistical Manual of Mental Disorders criteria, 5th edition (DSM-5 criteria) (published by  American Psychiatric Association, 2013)	other severe psychiatric disorders severe, such as schizophrenia and bipolar mood disorder; severe dependence criteria for other drugs (except tobacco); severe cognitive impairment; Illiteracy; compulsory hospitalization; hearing deficiency; transference to other health service with no partnership with the project; hospitalization discharge due to agressive issues or at the request of the participant; previous use of biperiden	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-6t74w6g	Bisphenol-A release in orthodontic materials used to treat anterior open bite.	Recruitment completed	Intervention	2022-06-29	<NULL>	<NULL>	5454	Bisphenol-A release and biocompatibility of orthodontic adhesive system used for spur bonding in patients with anterior open bite: In vivo study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6t74w6g	<NULL>	Subjects will be included in the study: Systemically healthy; with good oral hygiene; with presence of anterior open bite; Normal periodontal: The periodontal parameters adopted to assess the normal state will be those established by Lindhe, Lang and Karring (2014) and Carranza and Sznajder (1996). These parameters are Probing Depth, Visible Plaque Index, Gingival Index, and Probing Bleeding Index .	Subjects will be excluded from the study: With severe systemic alteration; on antibiotics and anti-inflammatory drugs in the last three months; with abnormal periodontium; patients with clinical signs of parafunctional habits; who have performed restorations in the last 12 months; periodontal sites that showed bleeding during crevicular fluid collection or sites that prevent adequate collection of clinical parameters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-292qvqs	Bladder catheter duration after Urethral Stricture correction surgery: a randomized trial	Recruiting	Intervention	2023-02-23	<NULL>	<NULL>	5918	Duration of urethral catheterization after Urethroplasty: a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-292qvqs	<NULL>	Male; 18 years of age or older; diagnosis of urethral stenosis with indication of anterior urethroplasty	Posterior urethral stenosis; bladder neck sclerosis; vesicourethral anastomosis stricture; neurogenic etiology for urinary symptoms or requiring intermittent bladder catheterization; previous anterior urethroplasty; staged urethroplasty; urethral fistulas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-3zfkgt	Bleaching efficacy and tooth sensitivity of active application of a in-office bleaching agent	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2988	Clinical evaluation of 20% hydrogen peroxide in-office bleaching gel effectiveness with and without sonic activation in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3zfkgt	<NULL>	Being aged 18 years old or older, having good general and oral health, having anterior maxillary teeth free of cavity or restorations on buccal surface, having maxillary central incisors shaded on C2 ou darker assessed by Vita Classic (Vita Zahnfabrik, Bad Säckingen, Alemanha).	Participants with orthodontic devices, pregnant or lactating, severe internal tooth discolouration (tetracycline, fluorosis or pulpal death), bruxism or other pre-existent pathologies that may cause spontaneous tooth pain (gingival recession or dentin exposure), non-carious cervical lesions, anterior restorations or who were using antioxidant or antiinflammatory drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-6g4mj6	Bleaching efficacy with two protocols in adults	Recruitment completed	Intervention	2018-07-06	<NULL>	<NULL>	1968	Bleaching efficacy of 35% and 38% hydrogen peroxide with two protocols in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-15	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-6g4mj6	<NULL>	To be included in this study participants had to be aged 18 years or over and had good general and oral health; participants should have at least 6 anterior maxillary sound teeth; at least 1 shade C2 or darker central incisor as assessed by value-oriented shade guide (VITA classical, Vita Lumin, Vita Zahnfabrik, Bad Säckingen, Germany).	Participants with restorations on the labial surface of their anterior teeth and non-carious cervical lesions; with full crowns or veneers; gingival recession; teeth treated endodontically or with spontaneous tooth pain; with internal tooth discoloration; teeth that had fluorosis; pregnant or lactating or had bruxism habits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-9p3w4hb	Bleeding Control after Tooth Removal in a patient using anticoagulant medication	Not yet recruiting	Intervention	2023-04-13	<NULL>	<NULL>	6001	Use of Hemostatics in alveolar socket after Dental Extraction in anticoagulated individuals: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-15	Universidade de Cuiabá	Hospital Geral e Maternidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-9p3w4hb	<NULL>	Volunteers using anticoagulant therapy continuously; with Surgical indication for tooth extraction; with international normalized ratio (INR) values reported by prothrombin time of up to 3.5; who agree to participate in the research and sign the term of free and informed consent (TCLE) specific to the research in question	Volunteers with changes in preoperative laboratory tests that contraindicate dental surgery; when, for any reason, they suspend the continuous use of medication prior to surgery; individuals who do not cooperate with the postoperative instructions that interfere with the maintenance of the clot	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-24yqvc7	Blood alteration among pesticide applicators in the Western Paraná	Recruiting	Observational	2024-09-04	<NULL>	<NULL>	7318	Monoclonal Gammopathy of Undetermined Significance (MGUS) among pesticide applicators in the  Western Paraná	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-21	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-24yqvc7	<NULL>	Case group: volunteers; male; over 50 years old; current pesticide applicators or who have worked as pesticide applicators in the past. Control group: volunteers; male; over 50 years old; no history of exposure to pesticides	People under 50 years of age; regardless of whether or not they are exposed to pesticides	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-93rx9q	Blood flow occlusion in patients with knee osteoarthritis	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4311	Blood flow restriction with different load levels in patients with knee osteoarthritis: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-93rx9q	<NULL>	Individuals of both sexes will be included; 50 years old and over; diagnosed with bilateral or unilateral knee osteoarthritis (OA) according to American College of Rheumatology criteria; moderate tosevere (scores between 5 and 13 on the Lequesne Questionnaire); with a minimum score of 24 points in the Mini Mental State Examination and who sign the Informed Consent Form (ICF)	Individuals with a history of surgery or any invasive procedure of the affected knee(s) will be excluded; who have undergone a physical therapy or strengthening program for knee injuries in the past three months; planned events, such as knee replacement or travel, which may interfere with individuals&apos; participation during the study period; history of acute myocardial infarction and / or stroke; history of peripheral arterial disease and / or deep vein thrombosis; history of cancer that has generated limitations or restrictions to physical exercise; decompensated systemic blood pressure without medical supervision and changes in dose or type of anti-inflammatory or analgesic drugs in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-6m67nb9	Blood Flow Restricted Walking Training for patients with Lung Disease	Not yet recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8122	Effect of Walking Training combined with Blood Flow Restriction in patients with COPD and prolonged use of home Oxygen. Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6m67nb9	<NULL>	Patients of both sexes; aged 50 years or older; presenting with Chronic Obstructive Pulmonary Disease (COPD); using home oxygen; with an Modified Medical Research Council Scale  (mMRC) score between 1-3; who have clinically tested positive for at least two weeks; Review the Informed Consent Form	orthopedic or cognitive conditions that prevent them from performing functional capacity tests; , pulmonary embolism, stroke, acute myocardial failure, peripheral arterial disease; smokers; using beta-blocker medications; undergoing another form of non-drug treatment; patients who cannot tolerate the exercise session;exacerbation in the last two weeks; those who refuse to sign the Free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-6yqjpv6	Blood flow restriction mobilization for prevention of acquired weakness	Not yet recruiting	Intervention	2023-09-21	<NULL>	<NULL>	6458	Kinesiological Ultrasonography analysis of early active and passive mobilization with blood flow restriction in the prevention of acquired weakness in patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-14	Universidade Estadual do Piauí - UESPI	Universidade Estadual do Piauí - UESPI	https://ensaiosclinicos.gov.br/rg/RBR-6yqjpv6	<NULL>	Adults over 18 years old.  Both genders. Hospitalization for more than 24 hours in the ICU ward. The stay must be at least 72 hours	Neuromuscular pathology. Osteoarticular contraindication to mobilization. Amputees. Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-8gd9xf	Blood Glucose Values and Motor Development in  Children with Overweight after Intervention with XBOX games	Recruitment completed	Intervention	2019-02-01	<NULL>	<NULL>	4345	Metabolic And Motor Profile  of children with Excessive Weight after Intervention With Exergames	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8gd9xf	<NULL>	Children 6 to 11 years of age; both sexes; diagnosed with overweight like overweight and obese.	Children between 6 and 11 years, use medicament that influence cardiac autonomic activity,   respiratory or metabolic diseases diagnosed before the evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-6s3kkr	Blood pressure control with metoprolol or clonidine medications in ear, nose or throat surgeries in patients with high blood pressure	Recruiting	Intervention	2019-04-24	<NULL>	<NULL>	2628	Blood pressure control with metoprolol or clonidin in otorhinolaryngology surgery for poorly controlled hypertension patient	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-10-10	Hospital das Clínicas	Hospital das Clínicas	https://ensaiosclinicos.gov.br/rg/RBR-6s3kkr	<NULL>	Patients older than 18 years and up to 65 years old, hypertensive, who arrive at the surgical center to perform otorhinolaryngological surgeries	Patients with a heart rate of less than 60 beats per minute, patients with contraindication or allergy to clonidine or metoprolol, patients weighing less than 50 kg or patients weighing more than 100 kg, patients using a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-28qz9d	Blood pressure decrease in elderly after isometric training: does lactate play a role	Recruitment completed	Intervention	2020-10-04	<NULL>	<NULL>	4327	Influence of the Isometric Exercise on the functional capacity and cardiometabolic parameters of institutionalized elderly in the Federal District	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-07	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-28qz9d	<NULL>	"Men and women aged 60 and over;
Be a resident of the Long Term Care Facility for the Elderly;
Do not present any physical problem that restricts your autonomous participation during the execution of the tests;
Voluntarily accept to be part of the study;
Elderly people with sufficient cognitive ability to understand the requirements of the tests."	"Difficulty of independent mobility;
Impaired visual and auditory acuity;
Elderly people using drugs that compromise their reasoning and performance in tests;
Elderly people who present cardiac abnormalities on the electrocardiogram;
Elderly people with musculoskeletal problems that prevent them from performing the exercises proposed in the study;
Elderly people who do not complete anamnesis or tests."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-2jcys5	Blood pressure increase during strength exercise conducted with different loads in people with high blood pressure treated with amlodipine.	Recruiting	Intervention	2013-08-31	<NULL>	<NULL>	238	Intra-arterial blood pressure responses during resistance exercise of different intensities in hypertensive patients treated with calcium channel antagonist.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-09-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-2jcys5	<NULL>	"Essential hypertension
Men and Women
30 to 60 years
Sedentary
No target organ damage or secondary causes of hypertension according to the diagnostic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, University of Sao Paulo."	"Individuals with obesity (body mass index greater than or equal to 35 kg/m2),
Individuals with diabetes (fasting glycemia greater than or equal to 126 mg / dl),
Individuals with heart disease (previous diagnosis or alteration at rest or exercise ECG),
Average blood pressure greater than or equal 160/105mmHg.
Subjects who do not tolerate the study medication."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-8y3mrwg	Blood Pressure Reduction after Blood Flow Restriction Training	Data analysis completed	Intervention	2021-06-07	<NULL>	<NULL>	4729	Acute Effect of Blood Flow Restriction Strength Exercise on Blood Pressure in Women with Type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Ciências Sociais Aplicadas	Faculdade de Ciências Sociais Aplicadas	https://ensaiosclinicos.gov.br/rg/RBR-8y3mrwg	<NULL>	Female volunteers; age between 18 and 60 years; medical diagnosis of type II diabetes; not participating in systematic physical training programs.	Use of insulin, metformin and beta blockers during the study period; Lesão osteomioarticular que impossibilite a realização das condições de exercício propostas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-2kbs8k	Blood pressure response after combination of natural foods and exercise	Data analysis completed	Intervention	2018-04-18	<NULL>	<NULL>	1721	Influence of food and nutritional supplements on exercise-induced hypotension in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-08	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2kbs8k	<NULL>	Hypertensive; sedentary; non-diabetic	Use beta-blockers and calcium channel blockers; Do not participate in at least one of the four experimental procedures; Modify your eating habits during the study period; Do not follow the nutritional recommendations of the days prior to the experimental procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-3f9k4r	Blood pressure response in amputee individuals with high blood pressure after aquatic aerobic exercise	Recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3595	Acute blood pressure response in hypertensive individuals with amputation after aquatic aerobic exercise: a crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-02	Associação de Assistência à Criança Deficiente	Hospital e Centro de Reabilitação da AACD	https://ensaiosclinicos.gov.br/rg/RBR-3f9k4r	<NULL>	Individuals with a unilateral transfemoral amputation, who were male (women not included to avoid possible hormonal interference), aged between 40 and 65 years, with a medical diagnosis of systemic arterial hypertension (SAH) controlled with medication, with systolic blood pressure (SBP) ?160 mmHg and diastolic blood pressure (DBP) ? 100 mmHg at rest at the time of assessment; and already adapted to the water environment (so that a possible anxiety or fear of being in the pool could be avoided) will be included.	Individuals with a body mass index (BMI) corrected for amputees greater than or equal to 30 kg/m², with decompensated diabetes mellitus (DM) according to a previous medical assessment, with a history of a cardiovascular event (acute myocardial infarction, stroke) in the last three months, who were smokers, with renal failure, and had orthopedic problems or any physical or mental impairment that would hinder physical exercise will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-3xnqxs8	Blood pressure response to aerobic training in hypertension	Recruitment completed	Intervention	2022-04-12	<NULL>	<NULL>	5338	Interindividual responsiveness of blood pressure to the increase in the volume, intensity and duration of aerobic training in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-06	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3xnqxs8	<NULL>	Inclusion: Female participants; postmenopausal; systolic blood pressure and diastolic blood pressure lower than 160 and 100 mmHg.	Exclusion: active women; cardiovascular disease besides hypertension; limiting osteoarticular diseases; use of medications that directly affect the heart rate (i.e., beta-blockers); obesity stage 2 or greater; insulin-dependent diabetes mellitus; the presence of any cardiovascular alteration at resting or exercise electrocardiogram.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-2gt5t4c	Blood-derived eye drops in liquid and powder form for the treatment of severe dry eye	Recruitment completed	Intervention	2026-04-27	<NULL>	<NULL>	9141	Use of frozen and lyophilized blood components for the treatment of severe dry eye	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-06	Hospital de Clínicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Patients with a diagnosis of severe mixed dry eye; Patients with a therapeutic indication for the use of topical blood components on the ocular surface; Patients who agree to participate in the study and sign the Informed Consent Form (ICF); Minimum age of 18 years; Both sexes	Patients with an active ocular infection at the time of data collection; Pregnant or lactating patients; Patients who have had changes in pre-existing topical eye medications after the start of the study; Patients unable to attend all evaluations required by the study protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-2qpdw4	Bloog glicose control following surgery and the ocurrence of Infection on the surgical site among Liver Transplantation recipients	Recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1872	Postoperative Blood Glucose Control vs. Surgical Site Infection incidence among Liver Transplantation recipients: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-21	Escola de Enfermagem da Universidade de São Paulo	Santa Casa de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-2qpdw4	<NULL>	"Liver transplantion recipients, age of 18 years or older.
Liver transplantation recipients whose allograft came from deceased donors."	"Liver transplantation recipients underwent any kind of surgery with or without prosthesis implant in the 30 days before the transplantation.
Liver transplantation recipients who will be submitted to multiple organ transplantation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-108b5jqc	Blue LED in the treatment of skin lesions caused by Radiotherapy	Recruiting	Intervention	2024-02-08	<NULL>	<NULL>	6777	Effects of Blue LED Photobiomodulation in the prevention of Radiodermatitis in oncology patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-108b5jqc	<NULL>	Men and women; older than 18 years; diagnosed with cancer referred to the Santa Maria University Hospital physiotherapy outpatient clinic for physiotherapeutic treatment; with indication of radiotherapy	Unable to understand guidelines, such as those regarding the effects, protocol and care; volunteers who miss three more sessions; patients who have already received radiotherapy sessions; with skin cancer; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-6rfj5vt	Bochecho com Camomila e Ácido Hialurônico para tratamento de feridas na boca causadas pela Radioterapia	Recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9174	Chamomile and Hyaluronic Acid therapy for the control of severe Oral Mucositis	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-17	Associação de Combate ao Câncer em Goiás	<NULL>	<NULL>	<NULL>	Participants of both genders; over 18 years of age; with head and neck cancer; who will undergo radiotherapy or chemoradiotherapy with a minimum total dose of 60 Gy and a minimum daily dose of 2 Gy; performance status score between 0 and 2	Participants with salivary gland tumors; those with Sjögren&apos;s syndrome; those with infectious diseases; individuals undergoing palliative radiotherapy; those with a history of previous cancer treatment in the head and neck region; participants diagnosed with lymphoma; those diagnosed with melanoma or skin cancer	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-6wmjys	Body awareness therapy in women after breast cancer surgery	Recruiting	Intervention	2015-05-13	<NULL>	<NULL>	470	Effects of body awareness therapy in cardiac autonomic modulation of women after surgery for breast cancer	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-20	Universidade Estadual Paulista Julio de Mesquita Filho- FCT/UNESP	Universidade Estadual Paulista Julio de Mesquita Filho- FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-6wmjys	<NULL>	Women undergoing removal surgery for breast cancer; regardless of the type of procedure; mastectomy or quadrantectomy; with up to 1 year after surgery. For the control group healthy women; who didn&apos;t have cancer.Both groups aged between 40 and 60 years.	For women who have had breast cancer include non-medical consent, diagnosed metastasis; be in period of treatment with chemotherapy or radiation.For women in the control group the exclusion will be present another diagnosed pathology or any other type of cancer.Exclusion for both groups include arrhythmias; cardiac pacemaker or transplantation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-8rpmcg	Body Composition and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2573	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8rpmcg	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-2xdpsr	Body Composition and Renal Function in Kidney Transplant Recipients: comparison between combined training and usual care.	Data analysis completed	Intervention	2020-02-17	<NULL>	<NULL>	3494	Quality of life, functional capacity, body composition and heart rate variability in Kidney Transplant recipients undergoing Physical Exercise Program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-2xdpsr	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-3jf9yn	Body fat values and Motor Development of children using Virtual Games	Recruiting	Observational	2020-10-01	<NULL>	<NULL>	4492	Motor Behavior of children with different body compositions in a Movement Interception Task	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3jf9yn	<NULL>	This study will include children with normopeso, overweight and obesity classifications according to BMI/age according to SISVAN (WHO, 2007). In addition to the permission to participate by the terms of consent (TCLE) signed by the guardians and consent (TA) signed by the child.	Excluded children will be those with previously diagnosed neurological, orthopedic or metabolic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-9vgrz75	Body Image Perception Disorder: Assessment Questionnaire for Candidates for Nasal Plastic Surgery	Recruiting	Observational	2023-08-02	<NULL>	<NULL>	6303	Body Dysmorfic Disorder: Assessment Questionnaire for Candidates for Nasal Plastic Surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-12-31	Hospital Paranaense de Otorrinolaringologia IPO	Hospital Paranaense de Otorrinolaringologia IPO	https://ensaiosclinicos.gov.br/rg/RBR-9vgrz75	<NULL>	Patients aged 18 years and over;  of both sexes; candidates for rhinoplasty will be included in the examination.	Patients with previously diagnosed severe behavioral disorders will be excluded from the study; A Free and Informed Consent Form will be applied to all study participants, excluding those who do not agree with the premises of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-35dtsg	Body image, self-compassion and self-esteem in young university students: A preventive intervention	Not yet recruiting	Intervention	2020-05-08	<NULL>	<NULL>	3824	Body image, self-compassion and self-esteem in young university students: A preventive intervention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Cristiany Seppe Faria	Universidade Federal de Juiz de Fora campus Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-35dtsg	<NULL>	As criteria for inclusion of participants, it is pointed out to be regularly enrolled in a higher course at the IFMG of Governador Valadares; and be between 18 and 35 years old.	"Individuals who indicate a recent diagnosis and / or treatment (last 12 months) of severe psychopathologies (psychosis, risk or attempted suicide, panic disorder and post-traumatic stress disorder) will be excluded.
Individuals who do not participate in all proposed steps (pre-intervention assessment; intervention; post-intervention assessment; and two-week post-intervention assessment) will be excluded.
And participants who demonstrate that they are not attentive to the proper completion of the instruments will be excluded, being classified as random respondents through low scores on the Conscious Respondents Scale (MARJANOVIC et al., 2014)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-5tf7ss	Body Perception treatment for women with eating disorders	Data analysis completed	Intervention	2020-11-11	<NULL>	<NULL>	4373	The Body Perception Therapy in women with Eating Disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-05	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-5tf7ss	<NULL>	To have clinical diagnosis of anorexia nervosa and bulimia nervosa; overestimation or underestimation in the Body Perception Index;age between 18 and 45 years; in the case of patients with anorexia nervosa, BMI below 18	Psychotic patients with severe depression	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-787ykrm	Body responses to Exercises of three different Intensities, acute and chronic	Data analysis completed	Intervention	2024-09-04	<NULL>	<NULL>	7314	Physiological, Biochemical, and Immunological responses to High, Moderate, and Low Intensity Exercises acutely and chronically	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade do Extremo Sul Catarinense	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-787ykrm	<NULL>	Present the signed Informed Consent Form (TCLE); be available to perform exercises three times a week; suit the age for each group between 20 and 40 years old; present a medical certificate authorizing participation; masculine gender	Give up before the intervention is due to complete; have a problem (physical) that makes it impossible to continue activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-2msy887	Body temperature regulation of elderly people who perform physical exercise in cold, temperate and hot environments	Recruiting	Observational	2024-10-09	<NULL>	<NULL>	7418	Behavioral thermoregulation during physical exercise in cold, temperate and hot environments: effects of aging	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-12-19	Departamento de Educação Física - Universidade Federal de Viçosa	Departamento de Educação Física - Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-2msy887	<NULL>	Both sexes; healthy;aged 18-30 and over 60 years old; physically active; no smokers; with normal cognitive function; with a reported absence of neurological diseases (including peripheral neuropathy and psychological diseases); with no use of medication (except oral contraceptives for women); with no cardiovascular and metabolic diseases; with eumenorrhea and no pregnancy (women)	By choice of the volunteer; exercise intolerance; intolerance or medical impediment to ingesting the temperature capsule; medical impediment of any nature	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-8fdcbc3	Body temperature-sensitive hydrogel based on green propolis for the auxiliary treatment of periodontal diseases	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8366	Thermosensitive Green Propolis hydrogel for use as an adjunct to periodontal treatment: clinical and laboratory analysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8fdcbc3	<NULL>	Both genders; with a minimum age of 18 years and no maximum age limit; minimum of 14 teeth present in the mouth (excluding third molars and teeth indicated for extraction); diagnosis of periodontitis stage 2 or 3 and grade B or C (at least 30% of teeth with at least one site with probing pocket depth (PPD) and clinical attachment level (CAL) equal or higher than 5 mm and bleeding on probing); systemically healthy patients; patients diagnosed with Diabetes Mellitus	Smoking, pregnancy; total edentulism; recent periodontal treatment; recent use of antibiotics; patients who refused to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-33qh2sy	Bodybuilding and Auriculotherapy as auxiliary treatments during Hemodialysis in patients with Kidney Disease	Data analysis completed	Intervention	2023-05-15	<NULL>	<NULL>	6077	Resistance Physical Exercise and Auricular Acupuncture as treatment tools non-pharmacological in Chronic Renal patients undergoing Hemodialysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-33qh2sy	<NULL>	Included in the study were patients of both genders; aged 18 years or older; who were under medical follow-up due to a diagnosis of chronic kidney disease; on hemodialysis for at least 6 months;	Patients who did not agree to participate in the research; those who died or dropped out; as well as those who were already doing auricular acupuncture and physical exercise outside the research will be excluded; Patients who had less than 75% adherence to the total number of sessions;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-10682pyr	Bone and gingival modifications around implants with immediate prosthesis installed by guided surgery	Recruiting	Intervention	2026-04-01	<NULL>	<NULL>	9046	Bone remodeling and soft tissue changes in immediate implants subjected to immediate loading and installed using the guided surgery and prosthesis technique	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Good general health (physical and mental) at the time of the surgical procedure; agreement with the informed consent; Individuals between 18 and 60 years of age; patients of both genders; need for implant placement in the anterior region due to teeth indicated for extraction	Smokers; alcohol abuse; drugs or medicines; positive history of systemic diseases that interfere with bone metabolism or treatment safety; coagulation disorders; serious heart disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-9sjh5rm	Bone Evaluation of Dental Implants Produced by 3D Printing in Mandible or Maxilla: clinical study	Not yet recruiting	Intervention	2022-11-25	<NULL>	<NULL>	5747	Marginal Bone Level Assessment of Additive-Manufactured Titanium Implants at 30 and 90 Days: 1-year non-inferiority within-subject randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade de São Paulo - Faculdade de Odontologia	M3 Health Indústria e Comércio de Produtos Médicos, Odontológicos e Correlatos Sociedade Anônima	https://ensaiosclinicos.gov.br/rg/RBR-9sjh5rm	<NULL>	Patients who are a minimum age of 18 years and a maximum of 70 years; with good general health; who have signed the Informed Consent Form; in need of rehabilitation with dental implants in areas of mandible or posterior maxilla (premolars and/or molars); with bacterial plaque index ≤ 20%; bleeding rate ≤ 20%; sufficient alveolar bone volume for an implant of 8 or 10mm length, diameter of 3.5mm, 4.00mm or 4.5mm, with bone quality type I-III and no associated bone regeneration required	Pregnant and lactating women; uncontrolled diabetes; history of chemotherapy or radiotherapy in the last 5 years; radiation therapy to areas of the head and neck; use of immunosuppressants, bisphosphonates or prolonged use of corticosteroids; smokers; alcohol or drug abuse; untreated periodontitis; history of previous bone augmentate in the implant installation region; presence of residual roots at the site to receive the implant; type IV bone density; individuals with connective tissue disorders or bone metabolic diseases; postmenopausal osteoporosis or other systemic diseases that may affect bone metabolism; need for guided bone regeneration at the time of implant placement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-22zvxw	Bone metastases treatment by image-guided freezing in patients with endocrine tumors	Not yet recruiting	Intervention	2018-07-03	<NULL>	<NULL>	2455	Cone-beam computed tomography guided percutaneous cryoablation approach of bone metastases of endocrine tumors	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Instituto de Radiologia do Hospital das Clínicas / Faculdade de Medicina da Universidade de São Paulo	Instituto do Câncer do Estado de São Paulo - ICESP	https://ensaiosclinicos.gov.br/rg/RBR-22zvxw	<NULL>	patients with bone metastases diagnosis evidenced by imaging exams (CT, MRI and/or PET-CT) and secondary to: papillary, folicular or medullary thyroid cancer; adrenal carcinoma; neuroendocrine carcinomas; metastatic bone lesions associated with: pain; risk of fracture; risk of spinal cord compression; hypercalcemia; age over or equal 18 years old; performance status (ECOG) of 0, 1, 2 or 3; life expectation over one month; patients must present pain symptoms from bone metastases and / or localized in a region of imminent risk of instability / fracture that may progress to neurological complication (for example, vertebral metastases) or functional impairment (for example, acetabular metastases); all patients must present diagnosis confirmation from metastases biopsy; the same treated patients can be treated again if they present new lesions during the study; all patients must be evaluated for treatment indication by a multidisciplinary team; the metastatic lesions may be located at the axial skeleton, costal arches, shoulder or pelvic girdle; each bone metastases assigned for treatment must be biopsy-proven and / or presenting elevation of thyroglobulin or calcitonin levels in the needle wash, if thyroid carcinoma is present; all patients must present five symptomatic bone metastases maximum; all selected metastases must have 7.0 cm diameter maximum;	"age bellow 18 years-old; active anticoagulant treatment
non-conclusive or benign cytologic specimens
pregnancy or breast-feeding undifferentiated thyroid neoplasia (anaplastic)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-7322n6s	Bone regeneration with absorbable membrane after tooth extraction	Recruiting	Intervention	2025-04-04	<NULL>	<NULL>	7888	Guided regeneration with Polydioxanone (PDO) membrane in dental alveoli after tooth extraction: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Universidade Estadual Paulista Julio de Mesquita Filho	Faculdade de Odontologia da Universidade Estadual Paulista Julio de Mesquita Filho - Campus Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-7322n6s	<NULL>	Have all four bony walls after the extraction procedure; over 18 years old; both genders; have signed the Free and Informed Consent Form	Uncontrolled systemic involvement; teeth in areas of tumor lesions; acute infectious processes; deciduous teeth; untreated periodontal problems; smokers; irradiated in the head or neck region; allergy to any component used in the research; psychological disorders; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-73jdz5	Botox study and facial Anesthetic Infiltration on the Tinnitus Intensity in Patients with Temporomandibular Disorders	Recruiting	Intervention	2020-06-02	<NULL>	<NULL>	3894	Clinical trial of botulinum toxin and facial anesthetic infiltration in tinnitus intensity in patients with temporomandibular disorder	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Hospital Universitário Professor Edgard Santos/UFBA	Hospital Universitário Professor Edgard Santos/UFBA	https://ensaiosclinicos.gov.br/rg/RBR-73jdz5	<NULL>	Temporomandibular joint disorder diagnosis; otoneurologic symptoms for at least three months; at least 15 years of age; both genders; no current treatment for temporomandibular disorder or otoneurologic disease.	Allergy to lidocaine or botulinum toxin; anyone who changed therapies during the study to avoid false-positive; imunossupressed patients; diabetes mellitus; cognitive impairment; pregnancy or breast feeding; psychiatric disorders; skin conditions; clotting disturbances; neuromuscular diseases; using clacium channel blokers; antibiotics (aminoglycosides); cyclosporin; chloroquines; hydroxichloroquine; D-penicillamine; or anu=y other substance that interferes with neuromuscular transmission; Myasthenia gravis; Eaton Lambert syndrome; Amyotrophic sclerosis; or any disturbances that promote periferal neuromuscular dysfunction;  oral anticoagulante; derivates from acetylsalicylic acid; derivates from vitemin E ou Ginko Biloba	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-5kkspwk	Botulinum Toxin Injections for Men with Erectile Dysfunction	Recruiting	Intervention	2025-10-23	<NULL>	<NULL>	8449	Intracavernosal Botulinum Toxin Use in the Treatment of Erectile Dysfunction	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-03-01	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-5kkspwk	<NULL>	Having an International Index of Erectile Function – 5 items (IIEF-5) score of 21 points or less; being over 18 years of age; currently using at least one available treatment option for erectile dysfunction, which must be continued throughout the study; having normal libido; and having a partner able to engage in sexual intercourse for treatment assessment.	Presence of urogenital neoplasms; history of radical prostatectomy; testosterone levels below 350 ng/ml; diagnosed depression with the use of antidepressants; anatomical abnormalities of the genital tract; insufficient sexual activity to allow assessment of the response to the proposed treatment; and any clinical condition that contraindicates the treatment planned in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-9xmfyq	"Botulinum Toxin type A for the treatment of 
smile with gum exposure"	Data analysis completed	Intervention	2020-07-01	<NULL>	<NULL>	3968	Evaluation of different doses of botulinum toxin type A for the treatment of gingival smile	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-08	Centro Brasileiro de Estudos em Dermatologia	Centro Brasileiro de Estudos em Dermatologia	https://ensaiosclinicos.gov.br/rg/RBR-9xmfyq	<NULL>	"Individuals aged between 18 and 70 years;
Superior anterior gingival exposure: more than 4 mm, for subjects included in group A and 2 to 4 mm, for subjects included in group B;
Presence of at least one indication for cosmetic treatment with botulinum toxin in the upper face;
Medical history and physical examination that, in the opinion of the investigator, does not interfere with the progress of the study;
Women of childbearing potential should have a negative urinary pregnancy test at visit 1. These subjects should use a highly effective contraception method during the study: combined oral contraceptives [estrogen and progesterone] or implanted contraceptives (with a stable dose for at least 1 month prior to study entry), bilateral tubal ligation, hormonal intrauterine device (inserted at least 1 month prior to study entry), strict abstinence (at least 1 month prior to entry into the study and agree to continue for the duration of the study), or vasectomized partner (at least 3 months prior to study entry) or use of condom;
Women presenting for childbearing potential (e.g. before menstruation, post menopause (absence of menstrual bleeding for 1 year before entry into the study), hysterectomy, or bilateral ovariectomy, less than one year postmenopausal);
Willingness to comply with protocol requirements and study duration.
Understanding and signing the Informed Consent Term (ICF) at baseline, before any study procedure is performed."	"Pregnant and/or breastfeeding women, or women who wish to become pregnant during the study period;
Any surgical intervention that has affected the area evaluated in this study;
Any cosmetic procedures, including fillers, or scars that may interfere with the results of the study;
Previous treatment with botulinum toxin for gingival smile less than 6 months ago, or for other indications on the face less than 12 months ago;
Evident facial asymmetry;
Active inflammation or infections in the treated areas;
Neoplastic, muscle or neurological diseases (e.g. Myasthenia Gravis, Lambert-Eaton Myasthenic Syndrome and motor neuron disease);
Serious psychiatric disorders;
Any other disease or chronic or serious decompensated medical condition that, in the opinion of the investigator, may interfere with the assessments or participation in the study or put subject at significant risk;
History of sensitivity to the formula components;
Current use of aminoglycoside antibiotics or penicillamines, quinines or calcium channel blockers or use at any time during the study;
Coagulation disorders or use of anticoagulants; 
Vulnerable subjects (such as those deprived of their liberty) as defined in Section 1.61 of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) for Good Clinical Practice (GCP);
Subjects with history of non-adherence to medications or showing difficulties to adhere to the study protocol;
Current participation in another drug or device clinical study OR participation within 30 days prior to Day 1 OR in a period of exclusion from a previous clinical study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-934r9sr	Brain activity of individuals with Sickle Cell Disease and Chronic Pain undergoing transcranial Direct Current Stimulation	Recruiting	Intervention	2026-03-09	<NULL>	<NULL>	8958	Dynamic brain connectivity of individuals with Sickle Cell Disease and Chronic Pain undergoing Non-invasive Neuromodulation	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-05	Fundação Universidade Federal do ABC	<NULL>	<NULL>	<NULL>	The study will include individuals with sickle cell disease (SCD), both genders, diagnosed by hemoglobin electrophoresis; aged 18 to 60 years; and with chronic primary musculoskeletal pain, diagnosed according to ICD 11 criteria, lasting three months or more. The group of individuals with SCD will consist of 40 individuals. The control group will include healthy individuals (without chronic pain and without SCD), matched by sex and age to the SCD and chronic pain group. The control group will consist of 20 individuals. Individuals with cochlear implants; cardiac pacemakers; or metal implants in the brain/ a history of traumatic brain injury; pregnancy; or a history of seizures or epilepsy will not be included in the study. The use of medications that modify the neuronal activation threshold (e.g., antidepressants, anticonvulsants, and antipsychotics) will be controlled	Individuals who wish to discontinue participation at any time or who experience any complications with the procedures will be excluded from the study. In this case, the data will be processed according to the intention to treat model, with the most recent results being repeated	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-82zbbb2	Brain alterations in adolescents and adults victims of sexual abuse	Recruitment completed	Intervention	2021-12-08	<NULL>	<NULL>	5088	Brain Connectivity and Neuroprogression. Multimodal MRI approach in victims of sexual abuse (adolescents and adults) with Post Traumatic Stress Disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-10	Universidade Federal de São Paulo	Columbia University	https://ensaiosclinicos.gov.br/rg/RBR-82zbbb2	<NULL>	Case: have been victims of sexual violence; age between 14 and 17 years; to have Post traumatic stress disorder (PTSD) diagnosis after the application of the  Clinician administered PTSD scale for children and adolescents (CAPS CA) performed in the screening; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficit. Controls: did not present psychiatric diagnoses through the scale Schedule for Affective Disorders and Schizophrenia for School-Aged Children (K-SADS) , did not have a traumatic event of sexual violence through the CAPS-CA scale; do not present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; do not present decompensated clinical diseases that require intensive treatment; do not present significant intellectual deficits; absence of use of psychoactive substances in the last 6 months; not being pregnant; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficits , intelligence coeficient( IQ)below 70.	Case: present psychiatric diagnoses prior to the traumatic event of sexual violence; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; Pregnancy detected through blood test.Controls: present psychiatric diagnoses; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery;  presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; pregnancy detected through blood test; have been sexually abused.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-6nr6hp5	Brain and Hormone Therapy after Menopause	Recruiting	Observational	2025-07-30	<NULL>	<NULL>	8169	Brain effects of Hypoestrogenism and Hormone Replacement in postmenopausal women: a prospective cohort study with multimodal Neuroimaging	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-10	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6nr6hp5	<NULL>	Hormonal therapy (HT) group: age between 45 and 55 years; absence of menstruation in the last six months and no more than 36 months; last spontaneous menstruation occurring after 40 years of age; plasma FSH levels greater than 40 IU/L and estradiol levels less than 25 pg/mL; clinical indication for HT; intention to administer HT for 16 or more uninterrupted weeks; have education greater than or equal to 7 years of formal study. N-HT group: women ineligible and/or who refused to receive hormone therapy: age between 45 and 55 years; absence of menstruation in the last six months and no more than 36 months; last spontaneous menstruation occurring after 40 years of age; plasma FSH levels greater than 40 IU/L and estradiol levels less than 25 pg/mL; have education greater than or equal to 7 years of formal study. Reference Group of pre-menopausal women: age between 35 and 40 years; have regular menstrual cycles; have education greater than or equal to 7 years of formal study	HT group: previous use of HT; use of antidepressants, anticonvulsants, benzodiazepines or other drugs with effects on the central nervous system; patients with major depressive disorder, anxiety disorder, bipolar affective disorder, schizophrenia or any other psychiatric disorder and neurological diseases with an impact on cognition; personal history of breast cancer; history of venous thromboembolism; history of stroke; established coronary disease; active liver disease; high-risk endometrial cancer; uterine bleeding of unknown cause. N-HT group: having undergone or currently undergoing non-hormonal pharmacological therapies for menopause; use of antidepressants, anticonvulsants, benzodiazepines or other drugs with effects on the central nervous system; women with major depressive disorder, anxiety disorder, bipolar affective disorder, schizophrenia or any other psychiatric disorder and neurological diseases with an impact on cognition; personal history of breast cancer; history of venous thromboembolism; history of stroke; established coronary disease; active liver disease; high-risk endometrial cancer; uterine bleeding of unknown cause. Reference Group of premenopausal women: irregular menstrual cycles; absence of menstruation in the last six months; having used or using contraceptive methods; use of antidepressants, anticonvulsants, benzodiazepines or other drugs with an effect on the central nervous system; women with major depressive disorder, anxiety disorder, bipolar affective disorder, schizophrenia or any other psychiatric disorder and neurological diseases with an impact on cognition; personal history of breast cancer; history of venous thromboembolism; history of stroke; established coronary disease; active liver disease; high-risk endometrial cancer; uterine bleeding of unknown cause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-4vdkhwv	Brain and tibial nerve stimulation to improve urinary symptoms in Parkinson’s disease	Not yet recruiting	Intervention	2026-01-17	<NULL>	<NULL>	8769	Transcranial and tibial nerve electrical stimulation on overactive bladder symptoms in Parkinson’s disease – a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Medical diagnosis of Parkinson’s disease. both genders. age greater than or equal to 18 years. use of antiparkinsonian medication at stable doses for at least four weeks prior to study inclusion. not undergoing any other treatment for overactive bladder during the study period, including pelvic floor physical therapy. presenting at least two symptoms of overactive bladder according to the definition by Haylen et al. characterized by urinary urgency with or without urinary incontinence, urinary frequency greater than seven voids per day and nocturia greater than one void per night. presenting a minimum score of 22.5 points on the Montreal Cognitive Assessment, translated and adapted version. agreement to participate in the study and signing of the informed consent form	History of bladder outlet obstruction. history of pelvic radiotherapy. active bladder carcinoma. history of peripheral nerve injury. active lower urinary tract infection. uncontrolled diabetes mellitus. pregnancy or immediate postpartum period less than six months. urinary incontinence exclusively due to stress. presence of a cardiac pacemaker or implantable defibrillator. presence of metallic implants. botulinum toxin application to the bladder and or pelvic muscles within the past year. history of seizures. current use of anticoagulant medications. current use of anticholinergic medications. other central or peripheral neurological disorders that may interfere with neuromuscular transmission	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-5435x9	Brain electrical stimulation associated with speech therapy in speech apraxia in young people with Trisomy 21 (Down Syndrome)	Not yet recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3509	Transcranial Direct Current Stimulation associated (tDCS) with Prompts for Restructuring Oral Muscle Phonetic Targets (PROMPT) in Apraxia of Speech in young people with Trisomy 21	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Federal do Espírito Santo	Ester Miyuki Nakamura Palacios	https://ensaiosclinicos.gov.br/rg/RBR-5435x9	<NULL>	They have to present clinical and / or genetic diagnosis of Trisomy 21 and meet criteria for intellectual disability (DSM-5) or intellectual development disorder (equivalent name found in ICD 11), and are classified according to the severity as mild (F70), moderate (F71), severe (F72), and profound (F73) according to ICD 10; they have to meet criteria for communication disorders (DSM-5), specifically speech sound disorder (F80.0); they should be clinically fit for the treatment proposed in the study and should therefore not present past or current illnesses that may be aggravated during treatment; they should also not have abnormalities in the laboratory tests, which may suggest a deterioration of their physical condition during the participation in the study; they should be able to understand the Portuguese language.	"It should not be included young people diagnosed with other associated mental disorders such as attention deficit hyperactivity disorder (ADHD), depressive and bipolar disorders, anxiety disorders, autistic spectrum disorder, stereotypic movement (with or without self-injurious behavior), impulsive disorders, and major neurocognitive disorders;
those who have any metal in their brain or skull (splinters, fragments, pins, etc.) except for titanium, history of epilepsy, severe head injury, cochlear implant, cardiac pacemaker or intracardiac metal lines, should also not be included because of restrictions on the noninvasive brain stimulation technique; they will not be included due to MRI restrictions if they are carrying metal implant such as: heart valve, plate, pin, screw, stent, brain aneurysm clip, body shrapnel, piercing, metal prosthesis, orthodontic appliance, electronic implants such as cardiac pacemakers, neurostimulators, cochlear implants, claustrophobic patients and those with permanent makeup or tattooing done in the last three months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-6c6f8yv	Brain Modulation in patients with Autoimmune Diseases	Recruiting	Intervention	2023-02-28	<NULL>	<NULL>	5924	Transcranial Direct Current Stimulation in patients with Systemic Autoimmune Diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-24	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6c6f8yv	<NULL>	Female patients with the defined systemic autoimmune disease Systemic Lupus Erythematosus (all meet the 2019 EULAR/ACR classification criteria); in regular outpatient follow-up; having a picture of fatigue or significant pain; presenting the Severity of Fatigue Scale (EGF) greater than or equal to 36 points; relatively stable use of medication in the last month; able to understand and complete the Free and Informed Consent Form (TCLE)	Patients with: neoplasms; cardiac pacemaker users; users of cranial metal clips or prostheses; pregnant women; personal history of seizures or epilepsy; users of centrally-acting drugs or drugs that lower the seizure threshold; skin lesion on the scalp; in moderate, intense or very intense disease activity; using moderate to high doses of glucocorticoids; overlapping with systemic autoimmune rheumatic diseases other than antiphospholipid antibody syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-74snjc8	Brain Neuromodulation in children with Cerebral Palsy	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7806	Transcranial Stimulation by Photobiomodulation and Direct Electrical Current in children with Spastic Cerebral Palsy: a double blind, controlled, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Universidade Brasil	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-74snjc8	<NULL>	Diagnosis of spastic cerebral palsy; functional classification on Levels I, II,III or IV of the Gross Motor Function Classification System (GMFCS); ability to walk independently in at least the previous 12 months, even if requiring a gait-assistance device; age between four and 12 years; both genders; degree of understanding and cooperation compatible with the execution of the proposed activities; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-10k7tx4w	Brain Stimulation in Parkinson&apos;s Disease: new findings on Brain, Vision, and Blood Markers	Recruitment completed	Intervention	2026-02-19	<NULL>	<NULL>	8884	Neuromodulation in Parkinson&apos;s Disease: effects on Cortical Activity, Eye Tracking, and Pro-Inflammatory Biomarkers	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-10	Centro de Ciências Humanas, Letras e Artes da Universidade Federal da Paraíba	<NULL>	<NULL>	<NULL>	"The study included people diagnosed with Parkinson disease of both sexes aged up to 60 years (Bagattini et al., 2023). They have a disease staging score between 1.0 and 2.5, which is considered compatible with the development of responses during application of the neurocognitive test battery (Hoehn &amp; Yahr, 1968). They have not been diagnosed with dementia. They have normal or corrected visual acuity, as measured using Rasquin E optotypes
No diagnosis of dementia.
Normal or corrected visual acuity 20/20 measured using Rasquin “E” optotypes."	The presence of metal implants and/or pacemakers. History of seizures. Participants with comorbidities such as diabetes mellitus, high blood pressure, schizophrenia and bipolar disorder. Use of illicit psychoactive substances and/or benzodiazepines within one week of the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-857zyyw	Brain Stimulation with Light for Chronic Migraine	Data analysis completed	Intervention	2026-01-07	<NULL>	<NULL>	8704	Photobiomodulation by Transcranial Infrared Light Stimulation (FBM) in Chronic Common Migraine (CCM)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-23	Município Do Cabo de Santo Agostinho	<NULL>	<NULL>	<NULL>	Volunteers of both sexes aged between 18 and 90 years; with more than 15 migraine days per month; using migraine prophylaxis medication in the last three months	Patients under 18 years of age; pregnant women; epileptics; patients with sequelae of acute or subacute stroke; patients who abuse analgesic medications for headaches; patients with catamenial headache; patients with less than 15 days of pain per month	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-10jpb6v7	BRALLA protocol	Recruiting	Observational	2023-09-13	<NULL>	<NULL>	6429	Adult Acute Lymphoblastic Leukemia treated with pediatric regimen – a prospective observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Servier Affaires Médicales	https://ensaiosclinicos.gov.br/rg/RBR-10jpb6v7	<NULL>	Patients between 16 and 50 years-old; both genders; with newly diagnosed Acute Lymphoblastic Leukemia - ALL; negative for Philadelphia chromosome; not previously treated (except for hydroxyurea, corticosteroids, or intrathecal chemotherapy) with at least 20% blasts in peripheral blood and/or bone marrow	Burkitt leukemia. Prior chronic myeloproliferative disease. Philadelphia chromosome positivity. ECOG&gt;2. Total bilirubin&gt;2x upper limit of normality. Transaminases&gt;5x ULN. Creatinine&gt;2,5 mg/dl. Positive serology for HIV or HTLV. Heart failure NYHA Class III or IV. Severe psychiatric disorder which prevents adequate compliance. Prior treatment with intravenous chemotherapy, except for hydroxyurea and corticosteroids. Refusal to participate in the study. Down syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-3z56bpx	Brazilian Fermented Beverage and Sports Performance	Recruitment completed	Intervention	2026-04-10	<NULL>	<NULL>	9084	Kombucha produced with brazilian native fruits: probiotic potential and effects on the performance of futsal athletes	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-20	Programa de Pós-graduação em Ciência de Alimentos da Universidade Estadual de Londrina	<NULL>	<NULL>	<NULL>	Participants of both genders may be selected; age range between 18 and 25 years old; non-smokers; those who have not consumed dietary supplements within one week prior to the start of the trial	Individuals who do not agree to participate in the study; individuals with chronic diseases; individuals who use vitamins; antioxidants; ergogenic agents; foods containing probiotics; patients who use antibiotics; anti-inflammatory drugs; subjects who have been absent from training and competitive activities due to overuse injuries for more than 7 days	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-9cvrrs	Brazilian Fruits and Heart	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2556	Brazilian Fruits and Heart	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual Paulista - Câmpus de Marília	Universidade Estadual Paulista - Câmpus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-9cvrrs	<NULL>	"Young adult men from 18 to 30 years;
Apparently healthy; active according to the IPAQ and BMI 18,5 e 29,99 kg/m2"	Individuals with cardiorespiratory; neurological; musculoskeletal; renal; metabolic; endocrine or other reported impairments will not be analyzed to prevent them from performing the procedures; individuals with SBP&gt; 130mmHg and DBP&gt; 90mmHg at rest; smokers; alcoholics; those who are under medication that influence the autonomic nervous system; sedentary and insufficiently active according to the IPAQ.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-54mj4m	Brazilian music effect on heart rate variability in overweight and obese subjects	Recruiting	Intervention	2015-09-17	<NULL>	<NULL>	618	Influence of Brazilian music in the variability of the heart rate of overweight / obesity: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-31	Universidade Presbiteriana Mackenzie	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-54mj4m	<NULL>	"Inclusion criteria: healthy volunteers; male gender; aged between 18 and 35 years; body mass index (BMI) above 24.9 kg / m2. This sample was chosen by recognized experience an increased sympathetic activity.
Individuals will be recruited from advertisements carried in the Mackenzie University and Federal University of Sergipe ."	Exclusion criteria: female gender; volunteers in use of cardiac pacemaker fixed frequency; diagnosis of chronic arrhythmias. Discontinuity criteria: subjects presenting instability in record heartbeat; inability to stand still during the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-786rf7z	Brazilian Red Propolis Gel for Oral Mucositis from Chemotherapy	Not yet recruiting	Intervention	2025-12-05	<NULL>	<NULL>	8621	Clinical and in vitro evaluation of a brazilian red propolis gel in patients with oral mucositis induced by antineoplastic chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Fundação Hospital Estadual do Acre - Fundhacre	<NULL>	<NULL>	<NULL>	Individuals of both sexes, aged 18 to 70 years, who started chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and docetaxel and presented grade 1 or higher mucositis	Patients with mandibular immobilization or mechanical fixation that prevents visualization of the oral cavity; indigenous patients; foreign patients; patients allergic to propolis, pollen, or with allergic predisposition or atopy to components of bee honey; patients with concomitant inflammatory or degenerative oral disease; patients undergoing chronic therapy with steroids or immunosuppressants; unconscious or sedated patients	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-42sf6c5	Brazilian study in children with spinal muscular atrophy	Recruiting	Observational	2024-10-10	<NULL>	<NULL>	7420	Brazilian observational study in children with SMA 5q (SOBRE5): effectiveness, safety and economic analysis of the use of the onasemnogen abeparvovec (Zolgensma) with real-world data	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-07	Hospital Universitário Professor Edgard Santos da Universidade Federal da Bahia	Hospital Universitário Professor Edgard Santos da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-42sf6c5	<NULL>	Confirmed genetic diagnosis of Atrofia Muscular Espinhal 5q type 1 or type 2; have previously received or have a confirmed court order for the use of the onasemnogene abeparvovec-xioi (Zolgensma), even if older than 24 months	Inability to locate children based on the data provided by the Ministry of Health. No other exclusion criteria are anticipated	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-6789t4v	Brazilian trial of Amantadine for disorders of consciousness after intracranial bleeding due to aneurysm rupture	Recruiting	Intervention	2023-01-19	<NULL>	<NULL>	5834	Amantadine for disorders of consciousness after Aneurysmal Subarachnoid Hemorrhage	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-01-20	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital Universitário Cajuru da Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6789t4v	<NULL>	Patients with spontaneous subarachnoid hemorrhage due to cerebral aneurysm rupture; adults; both genders	Unfavorable previous baseline neurological status, defined as modified Rankin Scale (mRS) greater than 2; pediatric patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-37vvwk	Brazilian version of Pre-PAQ Questionnaire	Not yet recruiting	Observational	2017-08-25	<NULL>	<NULL>	1347	Brazilian version of Preschool-age Children&apos;s Physical Activity Questionnaire (Pre-PAQ)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de São Paulo Campus Baixada Santista	Universidade Federal de São Paulo Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-37vvwk	<NULL>	Professional in the field of physical education; Professional physiotherapy; Occupational therapy	Less than 2 years of training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-10xxmhs3	Breast Cancer Survivors with Genitourinary Syndrome benefit from vaginal treatment with Erbium Laser: clinical and histological findings	Recruitment completed	Intervention	2025-09-02	<NULL>	<NULL>	8251	Use of Erbium Yag Laser in the treatment of Vulvovaginal Atrophy in women survivors of Breast Cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Centro de Pós-Graduação da Ciências Médicas de Minas Gerais – Faculdade de Ciências Médicas	Centro de Pós-Graduação da Ciências Médicas de Minas Gerais – Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-10xxmhs3	<NULL>	Women patient aged between 30 and 70 years.History of hormone-dependent breast cancer and use of hormone blockers. End of chemotherapy treatment.Patients who give their informed consent to take part in the study.Patients with at least 3 symptoms of genitourinary menopausal syndrome (GMS)	Patients who do not wish to have their data used in the study.Patients who refuse to undergo biopsy and cytological examination before or after treatment.Patients under 30 and over 70.Patients undergoing chemotherapy.Pregnant and breastfeeding women.Patients who do not have at least 3 symptoms of genitourinary menopausal syndrome (GMS).Patients who have already undergone previous vaginal laser treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-9pzj4vz	Breast diagnostic study by Magnetic Spectroresonance	Data analysis completed	Observational	2025-08-05	<NULL>	<NULL>	8185	Accuracy assessment of Breast Spectroscopy by Magnetic Resonance	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-09-20	Hospital da Clínicas da Universidade Federal de Goiás	Centro Avançado de Diagnóstico da Mama (CORA)	https://ensaiosclinicos.gov.br/rg/RBR-9pzj4vz	<NULL>	Women over 18; who agreed to participate in the study and signed the Free and Informed Consent Form; Health Unique System (SUS) users as BI-RADS 4 and 5 with breast anomaly or diagnosed by mammography and/or ultrasound and who have already received a recent diagnosis of breast cancer and who will be referred for incisional, excisional or reexcisional biopsy	Patients who present a high level of claustrophobia as we understand that the patient&apos;s non-cooperation could compromise the exam; pacemaker; surgical clips for aneurysms; bearers of neurostimulators; pregnant patients; and patients suffering from gunshot wounds with a projectile lodged and not removed; in addition to a previous history of reaction to gadolinium; women who were not the minimum age required for the study; did not agree to participate in the study or refused to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-6khstfv	Breastfeeding and Buzzy® in reducing pain during childhood vaccination: randomized clinical trial	Data analysis completed	Intervention	2025-04-28	<NULL>	<NULL>	7964	Pain management and the use of technologies in nursing care during childhood vaccinations	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-12	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6khstfv	<NULL>	Infants of both genders; aged two to twelve months; breastfed; who attended the sector to receive the pentavalent vaccine, at the time of data collection, accompanied by a legal representative, over 18 years old and who demonstrated consent for the infant&apos;s participation in the investigation	Infants who have not received the pentavalent vaccine for any reason; infants with a history of treatment with prophylactic analgesics within a period of up to eight hours prior to the administration of the vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-5trktfy	Breastfeeding and Skin-to-Skin Contact for Pain Relief in Newborns Undergoing Heel Puncture	Recruitment completed	Intervention	2021-05-27	<NULL>	<NULL>	4762	Use of Breastfeeding and Skin-to-Skin Contact in Pain Relief in Newborns Undergoing Heel Lance: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-16	Escola de Enfermagem Anna Nery	Maternidade Escola da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5trktfy	<NULL>	Full-term newborns admitted to the rooming-care, with a medical prescription for regular control of capillary blood glucose through heel puncture; showing signs that breastfeeding is being effective according to the breastfeeding observation form; suitable for gestational age (AGA), small for gestational age (SGA), large for gestational age (GIG) and underweight; without previous breastfeeding in the last 30 min; postnatal age ≥06 hours; APGAR ≥7 in the 5th min of life; clinical stability keeping the physiological parameters in the normal range, that is, heart rate between 120 and 140 bpm and SaO2 ≥ 89%. Mothers who wish and do not have a contraindication to breastfeed.	Newborns with dysfunction of the stomatognathic system that would interfere with the suction mechanics; using painkillers or other drugs that would interfere with responses to nociception or whose mother was receiving these drugs; in contact precaution, due to the amount of equipment available for collection; needed resuscitation maneuvers in the delivery room; admitted to the neonatal ICU shortly after birth, before being admitted in the rooming-care. Mothers who do not have clinical conditions to participate in the study (diagnosed with postpartum depression; those with immediate postpartum complications and birth trauma).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-8cchby	Breathing exercises before surgery abdominoplasty	Recruiting	Intervention	2016-02-01	<NULL>	<NULL>	706	Phyisical therapy preparation in respiratory complications in abdominoplasty Prevention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8cchby	<NULL>	Feminine gender; Body Mass Index between 20 and 30 kg/m2; with abdominal deformity type III Nahas; and type B Nahas.	Obstructive or restrictive respiratory disease; with abnormal chest x-ray; smokers; those with systemic diseases; subject to previous abdominal surgery; with supra-umbilical scars and post bariatric surgery with great weight loss; not carrying out the pre-breathing exercise operative as directed; or not attending the physical therapy session for the exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-65684zv	Breathing Exercises for preventing Cognitive Deficits in children  with Sickle Cell Disease	Recruitment completed	Intervention	2026-01-22	<NULL>	<NULL>	8790	The protective role of Breathing Exercises in preventing Cognitive Deficits in children  with Sickle Cell Disease	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Núcleo de Pesquisa em Oncologia	<NULL>	<NULL>	<NULL>	Children of both sexes; with a confirmed diagnosis of Sickle Cell Disease - SCD through hemoglobin electrophoresis; aged between 6 years and 13 years 11 months and 29 days; who assent and whose legal representatives freely consent to participation after being fully informed about the project	Children with associated diseases that affect the lungs and may cause bias in the results, such as cystic fibrosis or systemic sclerosis; children and adolescents with severe neurological sequelae that make it impossible to perform the proposed exercises	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4995qng	Breathing Exercises in Healthy Children	Data analysis completed	Intervention	2024-01-09	<NULL>	<NULL>	6713	Expiratory Muscle Training in Healthy Children: Randomized Clinical Trial	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2022-08-12	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4995qng	<NULL>	Healthy subjects, aged between 3 and 12 years old, who do not have comorbidities, will be included in the study.	Subjects with any type of comorbidity and who are younger than 2 years and 11 months or older than 12 years and one month will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-8y6cvnr	Breathing exercises to improve respiratory muscle strength and diaphragm movement in people with advanced chronic kidney disease who are not on dialysis	Recruiting	Intervention	2025-04-02	<NULL>	<NULL>	7878	Effects of an inspiratory muscle training protocol on respiratory muscle strength, thickness and diaphragmatic mobility of patients with Chronic Kidney Disease in the non-dialysis stage: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-08	Centro de Ciências da Saúde (CCS)	Centro de Ciências da Saúde (CCS)	https://ensaiosclinicos.gov.br/rg/RBR-8y6cvnr	<NULL>	Patients with a clinical diagnosis of Chronic Kidney Disease (CKD) in the non-dialytic stage, according to the criteria established by the National Kidney Foundation; aged between 40 and 70 years; male and female patients; clinically stable; without recent episodes of acute decompensation; capable of understanding and performing the maneuvers required for inspiratory muscle training (IMT).	Patients undergoing renal replacement therapy (hemodialysis; peritoneal dialysis; or kidney transplant); those presenting with acute or chronic respiratory diseases; neurological or musculoskeletal conditions that interfere with the performance of respiratory exercises; cognitive or behavioral incapacity that prevents participation in the study or adherence to the protocol instructions; or any other medical condition that renders the patient ineligible to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-29vzr84	Breathing muscle strength training for movement of individuals with stroke	Recruiting	Intervention	2022-03-20	<NULL>	<NULL>	5290	Inspiratory muscle training in functionality and swallowing in individuals with stroke	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-29vzr84	<NULL>	Individuals diagnosed with ischemic or hemorrhagic stroke; of both sexes; aged between 21 and 75 years, who present a stable clinical picture; with trunk control/balance deficit; hospitalized for treatment of the subacute event.	incapable of understanding the instructions in the tests, as well as those with aphasics and/or psychiatric disorders that make it impossible to carry out the prescribed exams; those who present oromyofunctional disorders that make it impossible to effectively use the respiratory stimulant; those with a previous history of dysphagia, orotracheal intubation or tracheostomy patients; those who present any pathology with transmission by contact or air, making the use of materials unfeasible; known heart diseases; Untreated SAH and smoking habit. During the post-discharge follow-up, deaths will be excluded; individuals who present a new episode of stroke and other comorbidities that compromise functional performance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-6zk87m	Brief Group Intervention to reduce alcohol use in men	Data analysis completed	Intervention	2020-02-09	<NULL>	<NULL>	3463	Brief group intervention to reduce alcohol use in men: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-25	Escola de Enfermagem Universidade de São Paulo	Escola de Enfermagem Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6zk87m	<NULL>	Men be over 18 years of age; who know how to read and write; and that they score AUDIT between 8 and 19.They should be classified as well risk use or harmful use of alcohol.	Being in treatment or attending a group related to the use of alcohol; be a carrier of cognitive disability that impedes the understanding of the terms of the research; being intoxicated or under the effect of some psychoactive substance; not have a telephone or home address.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-7rjt4t	Brief Intervention for Alcohol Use and Domestic Violence Among Women	Recruitment completed	Intervention	2013-10-17	<NULL>	<NULL>	259	Patterns of Domestic Violence and Alcohol Use Among Women: Effectiveness of A Brief Intervention In A Household Setting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-16	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7rjt4t	<NULL>	Women between 18 and 60 years old, enrolled previously in a household survey, who presented score equal to or higher than 8 in the AUDIT (high risk alcohol use)	Women with evident cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-57qgrj	Brief Intervention for elderly Alcoholic Beverages users	Not yet recruiting	Intervention	2018-09-28	<NULL>	<NULL>	2250	Brief Intervention for elderly Alcohol users	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Escola de Enfermagem de Ribeirão Preto - USP	Escola de Enfermagem de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-57qgrj	<NULL>	Participants will be eligible to screen those age 60 or older and have had contact with alcohol at least once in their lifetime.	The criterion of exclusion adopted will be to show visible difficulty in understanding and expressing oneself; being hospitalized due to some clinical complication; be sick and bedridden or have changed addresses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-65262c	Brief intervention for women who use alcohol	Recruiting	Intervention	2017-06-23	<NULL>	<NULL>	1266	Brief intervention for hazardous and harmful women´s alcohol consumption	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Escola de Enfermagem da Universidade de São Paulo	Secretaria Municipal da Saúde de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-65262c	<NULL>	Be female; Over 18 years old; Present risk or harmful alcohol consumption patterns; With the availability of attending the service during the necessary period	Visible behavioral changes; Signs of intoxication by psychoactive substances; Not having the Portuguese as their first language; Not have access to a landline or cell phone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-26qt3h	Brief intervention in group performed by nurses in the hazardous alcohol use	Data analysis completed	Intervention	2017-03-31	<NULL>	<NULL>	1201	Effectiveness of brief intervention in group performed by nurses in the hazardous alcohol use	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-11-15	Escola de Enfermagem Universidade de São Paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-26qt3h	<NULL>	People older than 18 years; with availability to attend the group for the time and given time; who could read and write; available to receive follow-up.	People with visible behavioral changes; intoxicated; not available to participate in the proposed intervention;  who refused to receive the follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-8rcxkk	Brief intervention to reduce alcohol consumption among older adults	Recruitment completed	Intervention	2020-03-09	<NULL>	<NULL>	8117	Evaluation of the effectiveness of a brief intervention to reduce at-risk drinking among older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-28	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8rcxkk	<NULL>	Above 60 years; both genders; registered at Primary Care Units of São José dos Campos city; consumption of 7 drinks or more per week	Participants that received treatment for problems related to drug use, except tobacco use, in the last 90 days; severe mental and physical illness that may impair data collection regarding alcohol consumption; patients that need emergency medical treatment or hospitalization; patients who are unable to communicate clearly and/or who are intoxicated at the time of screening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-5msn9mw	Bright light influence on blood vessel response to hand exercise	Recruitment completed	Intervention	2021-12-02	<NULL>	<NULL>	5070	Bright light influence on vasodilation induced by dynamic handgrip exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5msn9mw	<NULL>	Men; Aging between 20 and 39 years old	Body mass index higher than 30kg/m²; Blood pressure levels above139/89 mmHg; Presence of cardiovascular disease; Smoking; Be physicaly active; Use of regular medications; Take supplements; Presence of an extreme chronotypes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-4sn2n6	Bucket bath in newborns	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2694	Effects of Hydrotherapy on Weight Gain in Preterm Infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4sn2n6	<NULL>	The study will include patients with gestational age between 30 and 35 weeks; between 7 and 28 days of life; clinically stable; using enteral diet;	"Will be excluded from the study newborns using ventilatory support; with neurological impairment; diseases of the digestive tract; gastrointestinal fasting; changes in the thermoregulatory system, children of mothers diabetic patients with syphilis or hepatitis B and without the signature of the parents and
free and clear;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-8fdnky	Bulk fill composite resins	Recruiting	Intervention	2018-05-09	<NULL>	<NULL>	3443	Bulk fill composite resins: randomized and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-02	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8fdnky	<NULL>	All included patients will require at least five class I or II restorations in molars or premolars. The causes for composite resin restorations in this study may be fractures, large misalignments or other defects in existing amalgam restorations, or replacement of amalgam restorations for aesthetic reasons. In that case, the request must be made by the patient. Patients must be at least 18 years. Patients should have good general health, acceptable oral hygiene and availability of return during the evaluation periods. All teeth included in the study should have a normal occlusal relationship with the natural antagonist tooth, at least one contact with the adjacent tooth and those with marked occlusal stress, evidenced by severe occlusal wear, will be excluded. The cavities may involve enamel and dentin and should have a minimum depth of 3 mm.	Pregnancy or breastfeeding, non-vital tooth, allergies and idiosyncratic responses to product ingredients, occlusal contactless tooth with or without proximal contact, orthodontic treatment for less than 3 months, history of existing tooth sensitivity, prosthetic teeth fixed or removable, periodontal surgery performed less than 3 months ago, teeth or supporting structures with any painful pathology, bruxism, periodontal disease, known allergy to resinous materials, cavities to be restored shallow and / or narrow, impossibility to return to the recalls , fractured or visibly cracked teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8mq8bs	Buried or exposed pins in wrist fractures - What causes more infection? A randomized clinical trial	Data analysis completed	Intervention	2018-04-13	<NULL>	<NULL>	2939	Buried or exposed K-wires in distal radius fractures - What causes more infection? A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-09	Universidade Federal do Pará	Hospital Maradei	https://ensaiosclinicos.gov.br/rg/RBR-8mq8bs	<NULL>	Patients of both genders; equal or over 18 years-old; with distal third radius fracture treated with closed reduction and percutaneous fixation with 2 Kirschner wires of 1.5mm of caliber.	Patients under 18  years-old; open fractures; Immunossuppressed patients;  necessity of more than two Kirschner wires to fix the fracture; open reduction; associated fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-5npk9s	Buzzy® and Distraction®: relief of pain in childhood vaccination	Recruitment completed	Intervention	2018-12-13	<NULL>	<NULL>	2384	Use of Buzzy® and Distraction® devices for patient reflief during child vaccination	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5npk9s	<NULL>	Inclusion among children aged two to four years who attended the UBS for vaccination, accompanied by at least one of their legal guardians, were considered eligible for inclusion for injectable immunization recommended by the PNI vaccination schedule for their respective age group.	Participants who took any analgesic in the last six hours were excluded from the sample; have some type of injury or abrasions in the region where the device will be placed; have a history of syncope during procedures involving needle; have a fever; vomiting; lowering of consciousness level; or have some type of deficiency or underlying neurological disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-4vknryn	Cabbage in the treatment of Menopausal Genitourinary Syndrome	Recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6681	Randomized clinical study of the efficacy and clinical safety of Brassica oleracea in the treatment of Menopausal Genitourinary Syndrome - pilot study with analysis of quality of life and urogenital symptoms	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-20	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFM/USP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4vknryn	<NULL>	Woman, age equal to or greater than 50 years and less than 65 years. Clinical menopause for at least 3 years and presence of GSM - Genitourinary Syndrome of Menopause - symptoms according to established diagnostic criteria.  FSH (follicle-stimulating hormone) measurement &gt; 25 IU/ml and estradiol &lt; 20 pg/mL, when it is not possible to predict the date of the last menstrual period. Diagnosis of genitourinary syndrome identified by clinical data and supported by the Vaginal Health Index questionnaire. Negative cervical cytology exam, within the routine timeframe recommended by the Ministry of Health/Instituto Nacional do Câncer (INCA)	Allergy to cabbage, broccoli, kale, or any plant from the Brassicaceae family. Patients with severe depression or any other mental health condition that impairs study participation or other study requirements. Intact hymen. Altered oncotic colpocytology of the cervix and/or vagina. Active or recurrent genital infections (genital herpes or candidiasis). Active connective tissue diseases. Congenital or acquired immunosuppression. Decompensated diabetes mellitus. Differential diagnosis of vulvar pathology (atrophic lichen sclerosus, vulvar intraepithelial neoplasia, and vulvar Paget&apos;s disease). Decompensated thyroid disorders. Use of systemic or local steroid hormones or herbal substances such as teas, sitz baths, compounded or commercial herbal products, or hormonal therapy within the past 3 months. Patients with decompensated chronic diseases. Acquired immunodeficiency virus carriers. Patients who have undergone pelvic irradiation, pelvic surgeries, or hysterectomy for malignant disease. Patients with current or ongoing neoplasms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-37v2zt	CAD/CAM metal-free single crowns: a clinical study	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2555	CAD/CAM metal-free single crowns: a controlled randomized clinical study	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-05-03	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-37v2zt	<NULL>	Participants from 18 to 60 years old; which are indicated for total crowns on posterior permanent teeth; which are available for clinical follow-up throughout the evaluation period; participants willing to pay for laboratory costs; willing and able to undergo periapical / interproximal radiographic examination when necessary; be in accordance with the Informed Consent Form (TCLE); general health consistent with the clinical evaluation period; maxillo-mandibular relationship and occlusal stability.	History of allergy to some of the materials to be used in the research; pregnancy at the beginning of the experiment; use of drugs that may interfere with the oral environment; systemic or malignant diseases at the start of the study; impossibility to be submitted to the specific techniques for conducting the research; insufficient space for proper preparation of crowns; patients with parafunctional habits; pillars that endodontically and periodontally do not show predictability until the end of the evaluation period; periodontal disease; high risk of caries; absence of more than one tooth in the posterior region; unsatisfactory oral hygiene; use of removable partial dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-10qpynpd	Caffeine gel-cream in the treatment of Gynoid Lipodystrophy	Recruitment completed	Intervention	2023-12-19	<NULL>	<NULL>	6669	Development and evaluation of a pharmaceutical system containing Caffeine for the treatment of Gynoid Lipodystrophy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Faculdade de Farmácia da Universidade Federal do Rio de Janeiro	Unidade de Farmácia da Universidade do Estado do Rio de Janeiro Campus Zona Oeste	https://ensaiosclinicos.gov.br/rg/RBR-10qpynpd	<NULL>	Female participant; participant between 20 and 40 years old; with gynoid lipodystrophy grade II or III in thighs and/or glutes bilaterally; with a body mass index between 18.5 and 29.9 kg/m2	Skin infection; an inflammatory process on the skin; cancerous lesions; psoriasis; active acne; active herpes; in other procedures; in other procedures during the last 6 months; allergic to any asset used; pregnancy or breastfeeding; restrictive diet for weight loss; athlete or high-performance sports	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-7hx5wsk	Caffeine gum: impact on male beach volleyball athletes&apos; performance	Recruitment completed	Intervention	2025-06-30	<NULL>	<NULL>	8083	Effects of caffeine chewing gum on the performance of male beach volleyball athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-15	Centro de Ciências da Saúde e do Esporte	Centro de Ciências da Saúde e do Esporte	https://ensaiosclinicos.gov.br/rg/RBR-7hx5wsk	<NULL>	Be at least 18 years of age; to be of the masculine gender; regularly training and competing at a professional level in beach volleyball for at least 2 years; being free from chronic diseases; self-report of not regularly using any substance that could interfere with metabolic responses; self-report of not regularly using any nutritional supplement containing intracellular buffers	Possess a physical limitation that makes them unable to jump or attack; engage in physical activity within 24 hours preceding the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-5x8ttb	Caffeine supplementation can make runners run further and improve pace strategy	Data analysis completed	Intervention	2016-12-27	<NULL>	<NULL>	1121	Effects of creatine and caffeine supplementation association in street runners performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-21	Erico Chagas Caperuto	Elias de França	https://ensaiosclinicos.gov.br/rg/RBR-5x8ttb	<NULL>	Healthy participants which did not use any ergogenic supplements in the last 6 months preceding the test.	Individuals without previous experience in running on the treadmill; intolerant individuals to caffeine use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-39jnp4	Caffeine&apos;s Effects on improving Physical Performance	Recruitment completed	Intervention	2019-09-26	<NULL>	<NULL>	3000	The biology of Ergogenic Caffeine Effects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-39jnp4	<NULL>	Healthy subjects; male; age between 18 and 25 years; do not practice physical activities regularly. more than 150 minutes per week.	Lumbar disease; cardiac arrhythmia; convulsion; gastric problems; use of nutritional supplements or ergogenic aids; structural or functional deformities; cognitive problems; smoking; use of tricyclic antidepressants; use of caffeine-containing medicines; hypertension; diabetes; BMI over 25; phobia for blood collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-85fm7b	Caiu na rede Project Fell: adolescent health interventions on the triple frontier	Terminated	Intervention	2020-08-11	<NULL>	<NULL>	4112	Caiu na rede: strengthening intersectoral interventions in adolescent health care on the triple frontier	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-11	Fundação Parque Tecnológico de Itaipu	Fundação Parque Tecnológico de Itaipu	https://ensaiosclinicos.gov.br/rg/RBR-85fm7b	<NULL>	"Adolescents between 14 and 17 years old.
Adolescents enrolled in the institutions participating in the project."	"Adolescents under 14 and over 17 years of age.
Adolescents without ties to participating institutions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-8287pp	Calcium hydroxide as a root canal treatment material to anterior primary teeth.	Recruitment completed	Intervention	2017-07-18	<NULL>	<NULL>	1295	Calcium hydroxide as a filler material in pulpectomies of anterior primary teeth - Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-13	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-8287pp	<NULL>	Upper anterior primary teeth; Radiographic alteration suggestive of periapical lesion; Cavity that allows restorative recovery; Without any previous pulp treatment; Good systemic health.	Root resorption with more than 2/3; Radiographic rupture of the pericoronary sac of the permanent successor; Syndromes; Systemic changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-32f2k7r	CALLY Index and Its Relationship with Ulcerative Colitis Activation: Could It Be a New Evaluation Parameter?	Terminated	Observational	2025-10-28	<NULL>	<NULL>	8468	CALLY Index and Its Relationship with Ulcerative Colitis Activation: Could It Be a New Evaluation Parameter?	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-01	Akdeniz University	<NULL>	<NULL>	<NULL>	Patients diagnosed with active Ulcerative Colitis admitted to the hospital between June 2020 and December 2024; availability of complete medical history, laboratory parameters, and colonoscopic findings in the patient files; individuals considered as healthy controls for comparison purposes	Patients diagnosed with Ulcerative Colitis admitted outside the specified study period (June 2020 to December 2024); patients with incomplete medical history or missing data on disease activity, colonoscopic findings, or laboratory parameters; patients with concurrent diagnoses of other inflammatory bowel diseases (e.g., Crohn&apos;s Disease); patients with a history of colectomy; healthy controls with any active inflammatory disease or chronic systemic condition	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:47
RBR-6y6yn52	Can a body intervention improve body image in pain in people with chronic musculoskeletal pain?	Recruiting	Intervention	2025-05-14	<NULL>	<NULL>	8003	The Influence of a perceptual intervention on body image and pain perception of people with chronic pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6y6yn52	<NULL>	The inclusion criteria will be: age 20 and over; being able to understand Portuguese to fill in the questionnaires; - being able to move independently with or without the use of aids; having chronic pain for at least 3 months; having a score ≥ 35 on the Central Sensitization Inventory (CSI); having chronic pain with a diffuse distribution (≥ 3 areas).	Exclusion criteria will be neurological comorbidities such as Parkinson&apos;s, epilepsy, stroke; predominantly neuropathic chronic pain mechanisms with loss of peripheral sensitivity, strength or radiating pain; or inflammatory rheumatological diseases such as rheumatoid arthritis, ankylosing spondylitis, psoriatic, systemic lupus erythematosus, Scheuermann&apos;s disease; subjects who have undergone cancer treatment in the last 6 months; conditions in which magnetic resonance imaging is contraindicated, such as asthma, unstable cardiac conditions, or the use of continuous medication that could interfere with the acquisition of images; individuals over 80 years of age (senior citizens).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-4jmz36	Can a dental care intervention reduce the risk of death of patients treated in intensive care units? A clinical randomized study	Not yet recruiting	Intervention	2018-07-10	<NULL>	<NULL>	2276	Can a dental care intervention reduce the risk of death among critical patients? A cluster randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-02	Departamento de Medicina Social da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4jmz36	<NULL>	The intention to treat study population will consist of any patient with ages between 18 to 100 years old admitted for ICU admission during the study period. Subsequently, in the data analysis, those who remain hospitalized for at least 72 hours and have received at least two dental treatment sessions will be considered a per protocol subpopulation.	Patients who cross the washout period, ie remain in the ICU after the interval of 1 month between the alternation of intervention to control conglomerates and vice-versa, will be excluded from the study. This exclusion will only be from the database for analysis. This does not imply the interruption of dental care if the patient needs it.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-8s6zgk6	Can an injection with bone marrow material help shoulder arthritis?	Recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9108	Do Patients with Glenohumeral Arthropathy undergoing Bone Marrow Aspirate injection experience clinical and functional improvement? A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Patients of both genders; aged over 50 years; with symptomatic glenohumeral osteoarthritis that has not improved with appropriate conventional conservative treatment and with an indication for shoulder arthroplasty; with glenohumeral osteoarthritis grades 1 to 5 according to the Hamada classification.	Failure to sign the Informed Consent Form; psychiatric and/or cognitive disorders that preclude assessment and follow-up; coagulopathies; malignant neoplasm within the last five years; orthobiologic procedures in the same joint within the past 6 months; stroke or acute myocardial infarction within the last 3 months; intolerance or allergy to local anesthetic.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-66qtvq	Can Esophageal Varices in children be predicted without the performance of Endoscopy?	Recruitment completed	Observational	2017-09-29	<NULL>	<NULL>	1410	Can Esophageal Varices in children be predicted without the performance of Upper Digestive Endoscopy?	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Departamento de Cirurgia e Ortopedia da Faculdade de Medicina de Botucatu	Unesp-Universidade Estadual Julio de Mesquita-Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-66qtvq	<NULL>	patients with up to 15 years of age; in follow-up by portal hypertension of any etiology; that are not in use of beta-blocker;to agree to the free and informed consent of the parents or guardians and the of 12 years.	the use of beta-blocker, previous high gastrointestinal bleeding, having undergone portosystemic shunts or TIPS (intra-hepatic transjugular shunt), liver transplantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-24bbzs	Can Hormome replacement therapy of menopause  improve sleep and quality of life in menopausal women with Fibromyalgia?	Recruiting	Intervention	2018-12-01	<NULL>	<NULL>	3649	Influence of the hormone therapy on sleep and quality of life of menopausal women with fibromyalgia	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2018-08-28	Hospital de Clínicas da Universidade Federal do Paraná	Sociedade Evangélica Beneficente de Curitiba	https://ensaiosclinicos.gov.br/rg/RBR-24bbzs	<NULL>	Menopausal women with fibromyalgia; with 40 to 60 years old,; and presenting climacteric symptoms	There will exclude from the study the women who won&apos;t be able to comprehend and reply the questionnaires due to their limited cognition or idiomatic; the ones who have presented another associated autoimmune rheumatic disease (systemic lupus erythematosus, rheumatoid arthritis); the patients who have absolute contraindication to the hormone replacement therapy ( breast cancer, endometrium cancer,  acute an prior thromboembolism, acute or/ and severe liver disease,  acute heart disease and uterine bleeding no diagnosed)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-2r32rq6	Can Melatonin help you sleep better and protect your heart?	Recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8712	Melatonin intervention to improve the inflammatory profile and sleep of individuals with Cardiovascular Diseases	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Escola de Nutrição	<NULL>	<NULL>	<NULL>	Individuals undergoing treatment for cardiovascular disease; aged 19 to 60 years; of both sexes; with systemic arterial hypertension; dyslipidemias; diabetes mellitus; and high cardiovascular risk, determined according to the parameters of the Brazilian Guideline for the Prevention of Cardiovascular Disease in Patients with Diabetes (2017)	Use of anti-inflammatory drugs, immunosuppressants, or benzodiazepines; pregnant or breastfeeding women; presence of a diagnosis of renal insufficiency; thyroid disease; smokers; individuals undergoing hormone therapy; patients using antioxidant dietary supplements; significant dietary changes in the last 4 months; patients who present any of these criteria after the start of the intervention; and individuals who report digital illiteracy will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-8sd4fw4	Can removing proteins before Resin Infiltration improve the appearance of white spots in front teeth affected by MIH? A randomized clinical trial	Recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9076	Influence of Deproteinization as a pre-treatment for Resin Infiltration on the masking of opacities in anterior teeth affected by MIH: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-21	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Individuals aged between 6 and 14 years who present at least one permanent incisor with molar-incisor hypomineralization opacities of white-cream and yellow-brown coloration.	amelogenesis imperfecta; tetracycline staining; hypoplasia; fixed orthodontic appliances; previous restorations; dental caries; opacities restricted only to anterior teeth; teeth with post-eruptive fracture; patients whose parents do not allow participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-4wgg9bk	Can smartphones be an alternative to reducing sitting time?	Not yet recruiting	Intervention	2023-12-21	<NULL>	<NULL>	6671	Can Smartphone be an alternative to combat sedentary behavior?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4wgg9bk	<NULL>	Being 18 years of age or older; both genders; being duly registered; being regularly attending classes	Do not accept to participate in the research at any time; do not participate in one of the data collection moments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-7rtcpp6	Can Strength Training combined with Light Therapy reduce Insulin Resistance?	Not yet recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4931	Strength Training and Photobiomodulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-28	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7rtcpp6	<NULL>	"Be male or female;
Sign the informed consent form after reading and understanding it;
BMI &gt; 25 kg/m2;
Be between 18 and 60 years old;
Have stable body mass (variation less than 3 kg) in the last 3 months;
Not being diagnosed, and not showing signs and symptoms of cardiovascular, metabolic or kidney disease from medical history;
Being insufficiently active (&gt;150 min/week of moderate to intense physical activity) based on a questionnaire;
Being able to perform moderate to intense physical activity based on a questionnaire."	"Being diabetic, or diagnosed with another metabolic disease;
Being diagnosed with cardiovascular or kidney disease;
Perform 150 min or more of moderate-intense physical activity per week;
Not being able to perform physical exercise of moderate to intense intensity;
Present signs or symptoms of metabolic, cardiovascular or renal disease;
Make use of drugs with an effect on the metabolism, anti-inflammatory or anabolic steroids;
Present musculoskeletal injury that prevents the performance of tests and strength training;
Be pregnant;
Have fasting blood glucose &gt;125 mg/dl;
Present blood glucose &gt;199 mg/dl at 120 min of the oral glucose tolerance test;
Missing 10% or more of training sessions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-1047fwbf	Can the antibiotic Doxycycline help control the complications (dyskinesias) of levodopa treatment in patients with Parkinson&apos;s Disease?	Recruitment completed	Intervention	2022-05-12	<NULL>	<NULL>	5391	Pilot study to verify the safety and efficacy of Doxycycline in the treatment of levodopa-induced dyskinesias in patients with Parkinson&apos;s disease	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2021-03-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-1047fwbf	<NULL>	Patients 18 years of age or older; diagnosed with Parkinson&apos;s disease according to the United Kingdon Parkinson&apos;s Disease Society Brain Bank clinical diagnostic criteria; presenting at the initial evaluation with at least some functional impact dyskinesias (score higer than1 on item 4. 2 of the Movement Disorder Society - Unified Parkinson&apos;s Disease Rating Scale (MDS-UPDRS); who are using levodopa at least three times a day; and who can keep doses of antiparkinsonian medications unchanged for at least four weeks prior to screening and during study participation.	Diagnosis of atypical or secondary parkinsonism; treatment of any experimental drug or other intervention within 90 days prior to screening or baseline assessment; presence of moderate or severe psychotic symptoms (score greater than 2 on item 1. 2 of the Movement Disorders Society&apos;s Unified Scale for Assessment of Parkinson`s disease; diagnosis of dementia according to the Movement Disorders Society diagnostic criteria; suffering from serious systemic conditions (infections, malignancies, chronic kidney or liver disease); pregnancy or lactation; history of hypersensitivity or allergic reaction to tetracyclines; absence of clinical dyskinetic movements at baseline assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-10qfrrgh	Can the size of the wear near the gingiva affect pain intensity and imaging findings?	Data analysis completed	Observational	2022-03-27	<NULL>	<NULL>	5305	Analysis of dental pain and pulp status in teeth with non-carious cervical lesions and dental hypersensitivity- clinical, radiographic and tomographic diagnosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-13	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10qfrrgh	<NULL>	Participants included in this study, should be at least 18 years old, in good general and oral health and were required to have NCCL (Non-carious cervical lesions).	Teeth with presence of dental caries and restorations or fractures were excluded. Participants who underwent recent periodontal surgery or desensitizing treatment in the last three months and those with dental prostheses and orthodontics apparatus, teeth with or under endodontic treatment. In addition, pregnant and lactating women, individuals with bruxism or any systemic/psychological diseases, anti-inflammatory or analgesic drug users, smokers or patients undergoing tooth-whitening procedures were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-109vwvmd	Can the use of Sit-stand table associated with a Personalized approach change Sedentary behaviour of overweight/obese administrative workers?	Recruitment completed	Intervention	2022-10-25	<NULL>	<NULL>	5679	Can the use of Sit-stand table associated with the Personalized approach change Sedentary behaviour in an at-risk population? A quasi-experimental study with administrative workers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-109vwvmd	<NULL>	Do not report suffering from chronic health problems; work for a period equal to or greater than 4 hours in a sitting position; perform computer work for at least three years; have not been absent from work more than one month during the previous year, excluding the vacation period; carry out work activities in an environment that allows the installation and use of a sit-stand table for a period of six months; not be showing symptoms of the disease of COVID-19; being classified as overweight or obese through the Dual Energy X-Ray Absorptiometry (DXA) exam; agreeing to participate in the study.	Physical condition or illness preventing full participation in the study; having signs and symptoms of pregnancy or being pregnant; planning to relocate to another place of work or vacation during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-9f3wwp	Can turmeric powder treat asthma in children?	Data analysis completed	Intervention	2018-07-20	<NULL>	<NULL>	2037	Effects of Curcuma longa L. administration to children with persistent asthma	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2013-05-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Universidade de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-9f3wwp	<NULL>	Children between 7 and 18 years; with a diagnostic of persistent asthma, mild, moderate or severe, controlled or not.	Allergy to C. longa; parental request; failure to adhere to the treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-66hpcw7	Can whole genome sequencing improve Tuberculosis care?	Not yet recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7188	Evaluation of the implementation of whole genome sequencing for diagnosis, detection of resistance and choice of therapeutic regimen for Tuberculosis in clinical practice conditions	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Instituto de Ciências Biomédicas da Universidade de São Paulo - ICB/USP	Instituto de Ciências Biomédicas da Universidade de São Paulo - ICB/USP	https://ensaiosclinicos.gov.br/rg/RBR-66hpcw7	<NULL>	Both sexes. Be a patient of at least one of the six medical centers participating in this study during the data collection period. Patients with treatment failure or relapse in whom antimicrobial resistance is suspected, but diagnostic resistance tests have not been performed or who have a negative result for rifampicin resistance on the Xpert® MTB/RIF Ultra. Patients with a positive test for rifampicin resistance by Xpert® MTB/RIF Ultra. Patients with a negative test for resistance to rifampicin by the Xpert® MTB/RIF Ultra, but positive for resistance to any of the first-line drugs by the Hain ribbon genotypic tests (GenoType MTBDR). Patients with relapse and previous diagnosis of resistant Tuberculosis	Extrapulmonary tuberculosis at the time of diagnosis or diagnosed during the study. Negative culture. Co-infection with nontuberculous mycobacteria. Patients who change treatment centers during the study. Patients who wish to abandon the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-5fwhf7	Canabidiol in the treatment of sleep disorder associated with Parkinson&apos;s Disease	Recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1492	Canabidiol in treatment of REM behavior sleep disorder associated with Parkinson&apos;s disease- a double-blind placebo controlled clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade de Sao Paulo	Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5fwhf7	<NULL>	Diagnosis of PD according to criteria of the London Brain Bank in stage 1-3 of the Hoehn and Yahr scale;Over 18 years of age;Diagnosis of RBD according to the criteria of the 3rd edition of the International Classification of Sleep Disorders (CIDS-3);With sufficient severity and frequency to indicate a symptomatic treatment, ie with a frequency of 2 or more episodes per week;That they agree to participate in the study.	In adjustment of antiparkinsonian medications; With diagnosis of dementia; Presenting significant hallucinations (score&gt; 2 in the MDS-UPDRS psychosis item); Introducing delusions; With depression; Without a partner with whom you share your bedroom;With severe or decompensated systemic diseases;With probable mild TCSREM, with sporadic episodes and not clinically significant;Alcoholism or use of illicit drugs;Patients in stage 4-5 of the Hoehn and Yahr scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-87m8qg	Canal Treatment of deciduos teeth Antibiotics Creams	Recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3442	Pulp Therapy in deciduos molars using Antimicrobial Pulps: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-87m8qg	<NULL>	Children previously authorized by their parents to take part in the study through the Informed Consent Term (TCLE); Children aged 6 to 7 years; Children with satisfactory systemic health and who do not use continuous systemic medication for the treatment of acute or chronic diseases; Children who do not have any type of syndrome; Children who have at least one non-vital deciduous molar;	Non-restorable deciduous molars or perforation on the pulp floor;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8bdqzd	Cancer frequency among children and adults carrying or not a hereditary mutation that facilitate Cancer development, taking into consideration the diversity of the rural or urban environment where they live	Recruiting	Observational	2018-08-07	<NULL>	<NULL>	2103	Neonatal Screening, Mapping of the TP53 R337H mutation prevalence per municipality, Cancer history, socioeconomic profile and molecular alterations associated with tumors in the families	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Associação Hospitalar de Proteção à Infância Dr Raul Carneiro	Instituto de Pesquisa Pelé Pequeno Príncipe	https://ensaiosclinicos.gov.br/rg/RBR-8bdqzd	<NULL>	Newborn positive for mutation TP53 R337H; relatives of the positive newborn on the parental side who inherited the TP53 R337H mutation; both genders; age between 1 day and 120 years.	Relatives of the parental side who did not inherit the mutation TP53 R337H.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-36x4c4d	Cannabidiol as a treatment in patients with movement disorder	Recruitment completed	Intervention	2023-07-11	<NULL>	<NULL>	6227	Cannabidiol as a therapy for spinocerebellar ataxia	<NULL>	1, single-arm-study, single-blind	1	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-36x4c4d	<NULL>	Patients from the Movement Disorders Outpatient Clinic of the Neurology Service of the Hospital de Clínicas - UFPR (HC - UFPR) over 18 years old who already had the genetic diagnosis of spinocerebellar ataxia type 10 (SCA10); patients who agreed and signed the Informed Consent Form.	Patients who did not agree with the Informed Consent Form; patients who did not have a genetic diagnosis of SCA10; demented patients; and patients who did not use the intervention correctly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-6ryrpjs	Cannabidiol use in women with endometriosis and chronic pelvic pain: evaluation in pain and quality of life	Recruiting	Intervention	2021-05-28	<NULL>	<NULL>	4690	Cannabidiol use in women with endometriosis and chronic pelvic pain: a randomized duble-blind clinical trial for evaluation in pan and quality of life	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-12-01	Unifesp - Universidade Federal de São Paulo	Green Care Inc.	https://ensaiosclinicos.gov.br/rg/RBR-6ryrpjs	<NULL>	Patients diagnosed with endometriosis, with an suggestive image exam, who maintain pain (visual analogue scale more than 5) even in the course of drug treatment with hormonal contraceptives for at least 3 months before the inclusion of the study	Other types of clinical hormonal treatment (anastrozole, gestrinone, GnRh analogue); patients undergoing complementary treatment with physiotherapy, acupuncture, meditation; patients using other herbal medicines (Uncaria tomentosa); patients planning to become pregnant, pregnant and / or lactating women; patients with allergies to medication components; patients with psychiatric disorders; patients with liver disease, heart disease and / or kidney disease; patients taking medications with potential interactions (clonazepam, n-desmethylclobazam, topiramate, stiripentol, zonizamide, eslicarbazepine, rufinamide)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-5hd8ckd	Cannabis-derived product for analgesia in third molar surgery: A randomized, double-blind clinical trial	Recruiting	Intervention	2025-09-25	<NULL>	<NULL>	8314	Cannabidiol for preemptive analgesia in third molar extraction: A randomized, double-blind clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2025-08-13	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	https://ensaiosclinicos.gov.br/rg/RBR-5hd8ckd	<NULL>	Healthy participants without systemic involvement; of both genders; aged between 18 and 40 years; who required extraction of bilaterally impacted lower third molars diagnosed by orthopantomograms; Teeth with similar bilateral bone impactions, assessed by panoramic radiography, presenting the same dental impaction classification (IIB) according to Pell and Gregory (1933) and Winter (1926)	Research participants who used analgesics or anti-inflammatories in the 48 hours prior to tooth extractions; research participants with sensory-sensory alterations; research participants who are pregnant or lactating, or who present a positive rapid pregnancy test (to be performed on the day of the procedure); research participants with any history of hypersensitivity reactions to any of the medications that will be used in the study: mepivacaine, amoxicillin, ibuprofen, dipyrone, chlorhexidine, and cannabidiol; research participants who test positive at the time of surgery for previous use of Cannabis sativa (Test to be performed on the day of the procedure); research participants who present an infection or postoperative alveolith; research participants who do not follow postoperative recommendations; research participants who do not attend follow-up appointments; when the surgical time exceeds 60 minutes; when technical failure in anesthesia occurs or when the use of more than 3 anesthetic tubes is necessary; research participants who use any medication with analgesic and/or anti-inflammatory action in the postoperative period, in addition to those prescribed in the study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-8mxj56m	Capacitar, World Health Organization caregivers training program for parents of children with autism in Brazil	Recruitment completed	Intervention	2023-07-31	<NULL>	<NULL>	6292	Capacitar world health organization caregivers skills training program for parents and caregivers of children with developmental disorders	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal do Paraná	Secretaria Municipal de Saúde de Curitiba	https://ensaiosclinicos.gov.br/rg/RBR-8mxj56m	<NULL>	Caregivers of children between 2 and 9 years old, diagnosed with neurodevelopmental disorder or autism, who had been referred for treatment at a specialized municipal outpatient clinic and whose caregiver had time to participate in the intervention for 9 weeks	Those who did not show interest in participating in the program, who did not feel comfortable to carry out the training in the online modality in the second stage of the intervention, or who did not have access to the internet. Excluded those who did not remain after session 1.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-5pckyr	Capsaicin supplementation combined with aerobic exercise on food intake in young adults	Data analysis completed	Intervention	2020-07-24	<NULL>	<NULL>	4193	"Influence of acute capsaicin supplementation combined with aerobic exercise
dietary intake of physically active young people"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-19	Fábio Santos Lira	Priscila Almeida Queiroz	https://ensaiosclinicos.gov.br/rg/RBR-5pckyr	<NULL>	Healthy volunteers; male gender; age between 18 to 35 years; eutrophic; physically active; non smokers; stable weight in the last six months; without any types of cardiorespiratory impairments and orthopedic limitations that could compromise the participation of this intervention.	Presence of planned surgeries during the study period; any use of medication or psychoactive substances; use of any type of dietary supplement or use of nutritional strategies such as the use of ergogenics; reluctance to sign the informed consent form; participation in another study; alcohol or drug abuse; frequency below 75% in interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-8cz9kfq	Capsiate supplementation plus resistance training in adults	Data analysis completed	Intervention	2022-04-06	<NULL>	<NULL>	5331	Changes on performance, body composition and biochemical parameters in young adults after acute and chronic pre-workout supplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8cz9kfq	<NULL>	Men aged between 18 and 35 years; healthy; untrained for resistance training and without chronic diseases; do not make use of food supplements and steroids	Participants who miss more than three training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-4wjqxcv	Carbohydrate Reduction and Exercise in women with Polycystic Ovary Syndrome	Recruiting	Intervention	2023-05-11	<NULL>	<NULL>	6067	Low-carbohydrate Diet and Endurance Exercise for women with Polycystic Ovarian Syndrome: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (Fapesc)	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-4wjqxcv	<NULL>	Women between 18 and 50 years old diagnosed with polycystic ovary syndrome	Pregnant; lactating; climacteric women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-2h5b53	Carbohydrate supplementation in athletes	Data analysis completed	Intervention	2014-10-02	<NULL>	<NULL>	339	Effects of carbohydrate supplementation on physical performance, and hormonal,  immunological and psychological responses during and after an intensive training program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-08	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2h5b53	<NULL>	Male athletes, aged between 20 and 40 years old, running above 50 km / week, and minimum of 4 years of intense physical training.	Presence of orthopedic, or cardiovascular or hormonal / metabolic diseases, or anemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-9mqpwbw	Cardiac control after Pediatric Heart Surgery	Not yet recruiting	Observational	2025-04-21	<NULL>	<NULL>	7940	Cardiac autonomic control in the postoperative period of Pediatric Cardiac Surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-9mqpwbw	<NULL>	Children and adolescents diagnosed with congenital heart disease; of both sexes; aged between the first day of life and 17 years, 11 months and 29 days; who do not use a cardiac pacemaker; and with acceptance of the consent form by the child&apos;s legal guardians, and the assent form by the child over 2 years old	Inability to remain with the polar capture device for a specified period of time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-9sm9dp	Cardiac frequency in persons with visual deficienty	Recruitment completed	Intervention	2019-04-10	<NULL>	<NULL>	2590	Variability of cardiac frequency in persons with visual deficienty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-14	Faculdade de Medicina do abc de Santo André.	Faculdade de Medicina do abc de Santo André.	https://ensaiosclinicos.gov.br/rg/RBR-9sm9dp	<NULL>	"People of both sexes; over 18 years of age; with good visual acuity; healthy; and who do not need correctional lenses; such as glasses; will be eligible to form Group i. And people; also older than 18 years; both genders; but with visual impairment or blindness; in good general health; without other physical and mental disabilities; to constitute Group ii.
In this context; those who present visual acuity better than 20/30 in at least one eye will be admitted as participants of Group i; without visual impairment; and with visual impairment (Group II) those with visual acuity less than 20/70 and greater than 20/400 in the best eye; as blind people with visual acuity worse than 20/400; finger counts at 1 meter and even lack of light perception in the best eye according to criteria of the World Health Organization"	Those who do not meet the clinical criteria described or who refuse to participate or continue in the survey will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-9nyx8hb	Cardiac Rehabilitation after Myocardial Infarction	Recruiting	Intervention	2022-11-22	<NULL>	<NULL>	6326	Efficacy of Cardiac Rehabilitation after Acute Myocardial Infarction: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-23	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9nyx8hb	<NULL>	Clinical diagnosis of acute myocardial infarction (ECG and cardiac enzymes) with or without ST elevation and uncomplicated (Killip I or II); successfully submitted to percutaneous coronary intervention (PCI) (Flow Timi 3 or 2); age group between 18 and 70 years; both sexes;  classified as low risk (Absence of ventricular dysrhythmias, absence of clinical depression and absence of ischemic signs after the procedure)	Osteomioarticular alterations that prevent the performance of exercises; signs and symptoms of ischemia or cardiac decompensation; atrial or ventricular arrhythmias; EF (Ejection Fraction) &lt; 50%; diagnosed chronic lung diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-5d877q	Cardiac responses during rehabilitation in patients undergoing cardiac surgery	data analysis completed	Intervention	2012-04-04	<NULL>	<NULL>	151	Study of cardiac autonomic modulation and pulmonary function in patients undergoing coronary artery bypass grafting and physiotherapy program: phase I of cardiac rehabilitation.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-01	Universidade Federal de São Carlos	Irmandade Santa Casa de Misericórdia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-5d877q	<NULL>	"Coronary artery disease (CAD) 
Elective coronary artery bypass surgery (CABG) carried out with cardiopulmonary bypass (CPB)."	"Patients who had undergone coronary artery bypass surgery (CABG) without cardiopulmonar bypass (CPB) or concomitant surgery;
History of myocardial infarction &lt; 6 months before CABG, severely depressed LVF (left ventricular ejection fraction &lt;30%), acute significant arrhythmias, coexisting chronic obstructive pulmonary disease (COPD), autonomic neuropathy, severe non-cardiac disease; 
Inability or refuse to perform the proposed protocol."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-9g8d46	Cardioprotective effects of Electro-acupuncture	Not yet recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1782	Cardioprotective potential of Transcutaneous Electro-Stimulation in Acupuncture points in the preoperative Heart Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Instituto Nacional de Cardiologia	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-9g8d46	<NULL>	All patients between 18 and 80 years of age; who undergo an exclusive surgical procedure of valve replacement; and are hospitalized preoperatively at the National Institute of Cardiology will be eligible for the study.	Patients who present in the initial evaluation will be excluded from the study; pregnancy; presence of a cardiac pacing device; intermittent cardiodesfibrillator; hearing devices; skull trauma; brain injury; status epileptics; tetanus; adult respiratory distress syndrome; chronic liver disease; chronic kidney diseases; patients taking Sulfonylurea; Glibenclamide; who have already had previous heart surgery; cognitive alterations that impede the accomplishment of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-6ry6358	Cardiopulmonary analysis in patients with Stroke sequelae	Recruiting	Observational	2021-12-28	<NULL>	<NULL>	5129	Pulmonary function analysis and autonomic nervous system in patients with Cerebrovascular Accident sequelae	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-08	Universidade Federal do Triângulo Mineiro - UFTM	Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-6ry6358	<NULL>	This research will include male and female participants older than 18 years with subacute CVA (1-3 months after CVA)  and chronic (more than 6 months after CVA) and non sedentary healthy people, living in Uberaba&apos;s urban area.	The criterion for exclusion will be individuals with cognitive deficiency (examined with the Mini-Mental State Examination (MMSE)), individuals with lip apprehension difficulty, individuals with previous lung diseases, smokers and those who absent at any moment from the proposed assessment..	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-6mtkqcq	Cardiopulmonary and functional rehabilitation after COVID-19	Recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7137	Recover- Cardiopulmonary and Functional Rehabilitation in COVID-19 survivors	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Ciências Socias Aplicadas	Fundação Pedro Américo	https://ensaiosclinicos.gov.br/rg/RBR-6mtkqcq	<NULL>	Patients of both genders; who prove two negative rt-PCR tests for COVID-19 carried out at the place of hospitalization following criteria for hospital discharge of severely ill patients (CDC, 2021); who developed the severe form of the disease measured by the clinical progression scale proposed by the World Health Organization (WHO) (MARSHALL et al., 2020); who were hospitalized and admitted to the intensive care unit (ICU), intermediate care unit or ward, undergoing invasive (via orotracheal tube or tracheostomy) or non-invasive mechanical ventilation and oxygen therapy (high-flow nasal catheter or mask with reservoir bag ); and who were discharged from hospital at least 30 days before the start of rehabilitation	Participants who confirm reinfection will be excluded from the study; rehospitalization and hospitalization (MARSHALL et al., 2020); hemodynamically unstable patients (uncontrolled blood pressure and heart rate); unstable medical conditions, for example cardiovascular and pulmonary disorders (arrhythmias, decompensated atrial fibrillation, pulmonary thromboembolism, acute heart failure, pulmonary congestion, acute myocardial infarction and stroke); musculoskeletal and neurological conditions that affect mobility (paraplegia, tetraplegia, amputations and severe joint deformities); or cognitive and dementia conditions that make it impossible to answer the questionnaires and perform the exercise protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-5y8k7d7	Cardiopulmonary rehabilitation with and without blood flow restriction during resistance training in heart failure	Recruiting	Intervention	2026-01-27	<NULL>	<NULL>	8806	Exercise-based rehabilitation program with versus without blood flow restriction in individuals with heart failure with reduced ejection fraction	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Católica de Brasília	<NULL>	<NULL>	<NULL>	Patients aged between 40 and 70 years; of both sexes; diagnosed with Heart Failure with Reduced Ejection Fraction (HFrEF) or Heart Failure with Preserved Ejection Fraction (HFpEF); classified as functional class II or III according to the New York Heart Association (NYHA); on stable optimized medical therapy; heart failure with ejection fraction equal to or less than 40%	Any relative or absolute contraindication to exercise; presence of pacemaker with fixed heart rate and heart rate limits below the target proposed for physical training; major cardiovascular events or procedures performed within two months prior to study inclusion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-3tvtfzq	Cardiopulmonary Resuscitation Learning Program for school-age children	Not yet recruiting	Intervention	2024-03-15	<NULL>	<NULL>	6857	The social impact of the Cardiopulmonary Resuscitation Learning Program for school-age children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Centro Universitário Faculdade de Medicina ABC	Centro Universitário Faculdade de Medicina ABC	https://ensaiosclinicos.gov.br/rg/RBR-3tvtfzq	<NULL>	500 children and their respective teachers will be invited to participate in the research. All students from the second to fifth year of Elementary School I and the sixth and seventh year of Elementary II regularly enrolled in educational institutions participating in the research will be included	All students who do not sign the Informed Assent Form (TALE - Annex A) and parental consent form (Annex B), in addition to the authorization signed by the parents (Annex C) will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-2w5gczv	Cardiopulmonary resuscitation training: how practice in simulations can contribute improve cardiopulmonary arrest care	Data analysis completed	Intervention	2024-08-28	<NULL>	<NULL>	7286	Learning, satisfaction and self-confidence of nursing professionals submitted to different teaching methods (traditional or realistic simulation) of cardiopulmonary resuscitation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Fundação Cristiano Varella	Fundação Cristiano Varella	https://ensaiosclinicos.gov.br/rg/RBR-2w5gczv	<NULL>	Nursing professionals recently hired by the institution, within up to 90 days of admission; both genders; aged between 19 and 47 years	Incomplete filling out of assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-10c6922p	Cardiorrespiratory telerabilitation for patients post covid-19 hospitalization in brazil: randomized clinical trial	Recruiting	Intervention	2021-08-03	<NULL>	<NULL>	4809	Cardiorrespiratory telerabilitation for patients post covid-19 hospitalization in brazil: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-10c6922p	<NULL>	Patients aged 35 to 85 years; after hospital discharge caused by COVID-19 infection (diagnosis confirmed or highly suspected by laboratory or tomographic examination); hemodynamically stable (absence of severe arrhythmias; uncontrolled arterial hypertension), absence of the use of tracheostomy, and against indication to perform the proposed tests (such as previous orthopedic disease, unstable angina, and acute myocardial infarction in the previous 6 months, severe valve disease, etc); not bedridden, being under medical supervision; who are not being treated for diseases severe chronic conditions (such as cancer, chronic renal failure, neuromuscular diseases) who have access to a cell phone or computer and who have limitations in physical capacity (80% or less in the performance of the proposed physical tests).	Patients with cognitive balance deficit, with the risk of falling when performing the proposed physical tests and giving up participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-7n2srw8	Cardiovascular and functional effects, health-related benefits and safety of different intensities of community-based exercise in older women under socioeconomic vulnerability: The COmmunity-Based EXercise in OLD age (COBEX-OLD) study	Recruiting	Intervention	2024-07-21	<NULL>	<NULL>	7145	Cardiovascular and functional adaptations, health-related outcomes and safety of different intensities of community-based exercise in older women under socioeconomic vulnerability: The COmmunity-Based EXercise in OLD age (COBEX-OLD) study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7n2srw8	<NULL>	To be women (feminine sex) under socioeconomic vulnerability; age equal or greater than 60 years; do not have participated in structured physical exercise programs during the three months prior to the enrollment in the study; do not have uncontrolled cardiovascular or metabolic diseases; do not have musculoskeletal, neurological or pulmonary disorders that impair physical exercise participation	Do not return for follow-up evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-10h3vtwm	Cardiovascular and sensory responses during Passive Ankle Movement in Elderly individuals	Not yet recruiting	Intervention	2025-04-01	<NULL>	<NULL>	7875	Cardiovascular and perceptual responses during Passive Ankle Mobilization in Elderly individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Hospital Israelita Albert Einstein	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-10h3vtwm	<NULL>	Both genders; age equal to or greater than 60 years; have no history of heart disease and do not have orthopedic problems; are not involved in the practice of regular systematic physical activity more than once a week over the last six months prior to the beginning of the study; do not have a body mass index greater than 30 kg/m2; have calf skinfold thicknesses of less than 20 mm due to the interference of adiposity in the penetration of light from the Near-infrared Spectroscopy (NIRS) probe; and are able to perform a passive ankle mobilization session	Participants who are smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-64bhs5	Cardiovascular effects in subjects with pre-hypertension during maximal repetition test	Recruiting	Intervention	2017-05-06	<NULL>	<NULL>	1225	Analysis of systolic blood pressure and autonomic modulation of heart rate in subjects with pre-hypertension during maximal repetition test	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-64bhs5	<NULL>	Adult volunteers; male gender; normotensive or pre-hypertensive according VI SBH Guidelines (2013); without musculoskeletal diseases; do not practice physical exercise within previous 24 hours before the analyzes.	Attendant of private human groups, as indigenous and others; to be anti-hypertensive pharmacological treatment user; to be carrier of musculoskeletal disorders in lower limbs; to be user of alcohol, tobacco, or cofee, as well as non-practitioner of physical activity during last 24 hours before the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2vmgq95	Cardiovascular effects of super short intense acceleration training in men with high blood pressure	Recruiting	Intervention	2024-08-01	<NULL>	<NULL>	7169	Cardiovascular effects of super sprints training shorts in men with arterial hypertension	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de Mato Grosso do Sul - UFMS	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-2vmgq95	<NULL>	Men. Age between thirty and sixty years. Previous medical diagnosis of primary hypertension or use of at least one antihypertensive medication. Stage one arterial hypertension diagnosed at least one year ago. If taking antihypertensive medication that has not changed for at least two months. Have not participated in regular exercise programs in the last three months prior to the study. Agree to sign the informed consent form. Volunteers without arterial hypertension must only meet the criteria for males. Age between thirty and sixty years. Abstained from regular exercise in the last three months. Agree to sign the informed consent form	Significant comorbidities such as heart failure; chronic obstructive pulmonary disease; changes in cognitive impairment or psychiatric illness; previous stroke; neuromuscular disease; asthma; uncontrolled diabetes; peripheral vascular disease; grade three obesity; renal failure; sleep apnea; malnutrition or other diseases that interfere with protocol performance; secondary hypertension; individuals with contraindications to performing a symptom-limited maximal exercise test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-9s8t88	Cardiovascular effects of the perineal muscles contractions in pregnant women	Recruiting	Intervention	2016-04-27	<NULL>	<NULL>	817	Cardiovascular responses to pelvic floor muscle contractions in pregnant women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9s8t88	<NULL>	18 weeks of pregnancy;age group of 18 to 40; body mass index (BMI) for gestational age according to Atalah Table (Atalah SE et al, 1997).; first or second pregnancy.	High-risk pregnancy; drugs use; prolapse of pelvic organs; history of pelvic surgery; taking drugs that influence BP and HR (beta blockers; calcium channel inhibitors; anti anxiety drugs); vaginal palpation Intolerance (examination);inability to perform muscle contraction (P &lt;2 according to PERFECT method Laycock&amp; Jerwood (2001)); changes in the cardiovascular and respiratory systems; cardiovascular and diabetes diseases diagnosed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-3v3zmd	Cardiovascular evaluation Exercise in patients with Sjogren&apos;s Syndrome	Recruitment completed	Intervention	2017-06-20	<NULL>	<NULL>	1260	Cardiovascular evaluation before and after Resisted and Aerobic Exercise program in patients with Sjogren&apos;s Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3v3zmd	<NULL>	Women with diagnosis of primary Sjogren&apos;s syndrome confirmed by the revised Classification Criteria of 2002; age between 18 and 90 years; understanding and signing of the free and informed consent term.	"Diagnosis of heart, lung, endocrine, or any other disease that impedes the practice of exercise;
Inflammatory joint activity that impedes the practice of exercise; Regular exercise for more than 4 weeks in the last 6 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-5n4y2g	Cardiovascular Health Care Program – PROCARDIO-UFV	Recruiting	Intervention	2013-10-21	<NULL>	<NULL>	260	Use of Different Strategies in Nutritional Intervention in the Cardiovascular Health Care Program – PROCARDIO-UFV	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5n4y2g	<NULL>	Age higher 20 years old, diagnosed cardiovascular disease or occurence of risk factors: dyslipidemia, hypertension, diabetes or metabolic syndrome, to be a worker or dependents&apos;worker or students of Federal University of Viçosa	Do not want to participate of the study; To be not a worker or dependents&apos;worker or students of Federal University of Viçosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-5w6gk2	Cardiovascular physiotherapy in the health care unit	Not yet recruiting	Intervention	2020-03-23	<NULL>	<NULL>	3646	Cardiovascular physiotherapy in primary care	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Estadual de Goiás	Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5w6gk2	<NULL>	Will be included in the study of sedentary patients of both sexes; without cognitive impairment (mini-mental more than 17);  aged 60 years or over; independent walking and CSF Jardim Dom Fernando II frequenters.	Elderly practitioners of regular physical activity (more than 150 minutes of moderate-intensity physical activity per week), with unstable angina, cardiac resynchronizer, cardiac surgery less than three months, heart failure (NYHA class III,IV), will be excluded. diabetes mellitus (fasting glucose more than 180 mg.dL and or glycated hemoglobin more than 7.0%), chronic renal failure (glomerular filtration less than 50 ml.min.1.73m2), with impaired cognitive impairment, need walking aids for locomotion or any clinical condition that prevents physical activity and the impossibility of attending the physiotherapy sector twice a week during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-66nkyy3	Cardiovascular risk factors and subclinical atherosclerosis in children and adolescents with congenital heart disease	Recruiting	Observational	2021-09-12	<NULL>	<NULL>	4879	Association of dietary patterns, inflammation and intestinal microbiota with subclinical atherosclerosis in children and adolescents with congenital heart disease undergoing cardiac procedure	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-66nkyy3	<NULL>	Children and adolescents aged 5 to 18 years; of both sexes; diagnosed with congenital heart disease; underwent some type of cardiac procedure (therapeutic catheterization or cardiac surgery)	Secondary diagnosis, as malignant neoplasm, chromosomal abnormalities (trisomy 21, Turner, Noonan and others); primary or secondary familial dyslipidemia; diabetes mellitus; hypothyroidism; acute diseases in the last 15 days (Respiratory and gastrointestinal infections); other chronic inflammatory diseases (Lupus, hepatitis, arthritis, asthma, intestinal syndromes and others).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-6jr5nq	Cardiovascular risk factors assessment and the effect of physical activity and nutritional counseling for children and adolescents.	Data analysis completed	Intervention	2016-04-01	<NULL>	<NULL>	779	Cardiometabolic risk factors assessment and the effect of physical activity for children and adolescents: a continued study.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-09	Universidade Federal de Santa Catarina	Edson Luiz da Silva	https://ensaiosclinicos.gov.br/rg/RBR-6jr5nq	<NULL>	Be enrolled in a public school of the city of Guabiruba-SC, both genders, have abdominal obesity and/or dyslipidemia.	Present preexisting conditions that preclude the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-75tjp2n	Cardiovascular safety of the herbal medicine Aloysia polystachya (Griseb) Moldenke in controlled hypertensive patients: a randomized, double-blind, placebo-controlled clinical trial	Terminated	Intervention	2026-02-13	<NULL>	<NULL>	8874	Evaluation of the herbal medicine Aloysia Polystachya (griseb) moldenke (verbenaceae) in the treatment of systemic arterial hypertension: a randomized, double-blind, placebo-controlled clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade de Ribeirão Preto - UNAERP	<NULL>	<NULL>	<NULL>	Men, non-pregnant women. Age greater than 18 years and less than or equal to 80 years. Diagnosis of hypertension (systolic blood pressure &gt;= 140 mmHg and/or diastolic blood pressure &gt;= 90 mmHg) and on at least monotherapy for this disease and with good blood pressure control in the last month (assessed by interview and initial blood pressure measurement)	Pregnant or breastfeeding women. Individuals with secondary systemic arterial hypertension. Individuals with paroxysmal or permanent atrial fibrillation. Individuals using any other herbal medicine during the study. Individuals experiencing a serious adverse reaction to the medication such as anaphylaxis, severe hypotension, significant abnormalities in biochemical or hematological tests. Individuals with a BMI greater than or equal to 35. Individuals requesting to be withdrawn from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-1073gcfm	Care management in pregnant women	Recruitment completed	Intervention	2020-12-28	<NULL>	<NULL>	4445	Effect of Case Management on Pregnant Women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-27	Universidade Estadual do Norte do Paraná	Universidade estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-1073gcfm	<NULL>	Pregnancy diagnosis. Gestational age less than twenty weeks. Residents in the city of Bandeirantes in Paraná. Registered in the prenatal information system.	Interest in moving to another city. I leave in another city.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-5rzmzf	Care plan for carers of people with dependency	Not yet recruiting	Intervention	2019-10-11	<NULL>	<NULL>	3078	Instrumentation of informal caregivers of care-dependent patients during hospital-to-home transition	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-5rzmzf	<NULL>	"Care dependent person: age between 18 and 59 years; be the first episode of hospitalization for disabling illness; in the emergency care sectors; medical clinic or post-surgery sector of the University Hospital and Municipal Hospital; minimal upward forecast; have a Barthel index of 10 to 30 evaluated at the time of research recruitment;
 
Informal caregiver: 18 years of age and over and less than 80 years old; be primary informal caregiver; reside in the municipality; be literate; able to read and write; no intention to move the municipality during the research period; and be classified in the Mini Mental State Examination with scores between 22 24 and 26 according to educational level"	"Care dependent person: be transferred to a hospital or care institution other than home; need specialized health care;

Informal Caregiver: do not speak Portuguese"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-2b2vvf5	Caries prevention around the orthodontic appliance	Data analysis completed	Intervention	2021-08-23	<NULL>	<NULL>	4847	Effect of using low-viscosity resinous infiltrant (Icon®) to prevent carious lesions around orthodontic brackets: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	São Leopoldo Mandic	São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-2b2vvf5	<NULL>	Age between 12 and 20 years; incisors, canines and premolars present in the arch, all with a healthy buccal surface at the beginning of orthodontic treatment; ICDAS greater than 2; no history of previous orthodontic treatment.	Abuse of any type of medication, alcohol, nicotine or other types of drugs; systemic, metabolic or mental illness; craniofacial syndrome, cleft lip and / or palate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-4cmwkm	Caries preventive effective in relation to different types of sealants	Recruitment completed	Intervention	2015-06-09	<NULL>	<NULL>	510	Effectiveness of two sealant materials in preventing carious lesions in newly erupted first permanent molars.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-10	Universidade de Brasília	Renata Nunes Cabral	https://ensaiosclinicos.gov.br/rg/RBR-4cmwkm	<NULL>	5 to 7 years old children (n = 56) from a public school were orally examined and those that were classified as medium or high risk to dental caries and presenting newly erupted 1st molars without cavitated lesions were invited to participate	Parents that did not sign the informed consent and those children that did not allow the dental examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8ns8pb	Caring for type 2 diabetic people. Outcomes of the assessment of an Educational Program	Recruitment completed	Intervention	2017-10-19	<NULL>	<NULL>	1432	Nurse caring for adult type 2 diabetic people. What are the outcomes in lifestyle?	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Universidade de Lisboa	Universidade de Lisboa	https://ensaiosclinicos.gov.br/rg/RBR-8ns8pb	<NULL>	"Type 2 Diabetes
HbA1c over 7.5%"	Cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-55n74zm	Carotid-Body modulation through Meditation in Hypertensive subjects	Not yet recruiting	Intervention	2022-07-28	<NULL>	<NULL>	5514	Carotid-Body modulation through Meditation in stage-I Hypertensive subjects: study protocol of a  randomized and controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal de Mato Grosso do Sul	Hospital Universitário Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-55n74zm	<NULL>	Subjects of both sexes; aged between 30 and 70 years; patients with arterial hypertension or using at least one antihypertensive medication; stage I systemic arterial hypertension with a minimum diagnosis of 1 year; use of unchanged antihypertensive medication for at least 2 months; did not participate in regular exercise programs 3 or more times a week in the last 3 months prior to the study; are able to read; speak and understand Portuguese	Subjects who do not adhere to the experimental protocol; who have a diagnosis of heart failure greater than or equal to New York Heart Association I; chronic obstructive pulmonary disease; cognitive impairment that makes it impossible to understand the protocols; or psychiatric disease; previous stroke; neuromuscular disease; asthma; uncontrolled diabetes; vascular disease peripheral; obesity grade III; renal failure of stage greater than 2; sleep apnea; malnutrition; or other diseases that interfere with the performance of the protocol; and lack of more than two sessions of supervised meditation; secondary hypertension; individuals with contraindications to performing a symptom-limited maximal exercise test; and individuals who regularly practice meditation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7qr4rp	Carpal Tunnel Syndrome: physioterapic treatment aiming at hand and the column	Recruitment completed	Intervention	2018-11-08	<NULL>	<NULL>	2325	Carpal Tunnel Syndrome: physioterapic intervention and avaliation with interface between hands and vertebral column	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7qr4rp	<NULL>	20 women; aged 20 to 70 years; diagnosis of carpal tunnel syndrome; conservative treatment.	Smoking volunteers; history of alcohol or drug abuse; diagnoses of the central nervous system disease, musculoskeletal disease of the upper limbs or hormonal/metabolic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-75jm4cj	Carvedilol as a single-drug therapy for Heart Failure with recovered ejection fraction: an open label randomized clinical trial	Recruiting	Intervention	2022-05-20	<NULL>	<NULL>	6047	Open-label, pilot, randomized clinical trial evaluating the effect of withdrawing renin-angiotensin-system inhibitors and neprilisin inhibitors and maintaining Carvedilol in Heart Failure with recovered ejection fraction	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2022-04-12	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-75jm4cj	<NULL>	Patients with previous diagnosis of reduced ejection fraction heart failure and documented ejection fraction equal or under 40% and actual ejection fraction equal or more than 50% and 10% greater than previous; Age equal or greater than 18 years old; absence of symptoms related to heart failure; Currently using carvedilol and angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers or neprilisin inhibitor with or without spironolactone; NT-proBNP under 250pg/mL; heart rate between 50 and 60 or maximum tolerated dose of carvedilol after runin fase or at least 50mg/day of carvedilol.	Ischemic cardiomyopathy; hypertensive cardiomyopathy: stage 3 hypertension as defined by the Brazilian Guideline of Hypertension or current blood pressure higher than 160x90mmHg; chagasic cardiomyopathy; valvar cardiomyopathy; infiltrative cardiomyopathy; chronic renal disease with creatinine clearance less than 30mL/min/1,73m²; formal indication for angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers such as diabetic patients with hypertension, diabetic nephropathy or another nephropathy with proteinuria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-5sfkgpy	Cashew fiber in preventing obesity	Recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7849	Effect of Cashew Fiber (Anacardium occidentale L.) in the Prevention of Obesity: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-5sfkgpy	<NULL>	Healthy volunteers; body mass index between 25 and 29.9 kg/m²; age range between 20 and 39 years; non-smokers; non-alcoholics; both sexes	With comorbidities and/or complications such as kidney, liver, severe cardiovascular and gastrointestinal diseases; who use continuous medications (except contraceptives); allergy to any food ingredient used; women who are pregnant or lactating; individuals who drink alcohol or smoke; people who take fiber supplements or undergo weight loss treatments; individuals who perform moderate or high intensity physical activity for more than 30 minutes daily; individuals who present cognitive alterations, such as psychotic disorder resulting from a general medical condition and/or induced by substances, Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Brief Psychotic Disorder, Delusional Disorder and Psychotic Disorder without specification	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-7v2k495	Cashew nut plant-based beverage and its effects on the health of climacteric women	Not yet recruiting	Intervention	2026-01-15	<NULL>	<NULL>	8763	Consumption of vegetable drink based on by-products of chestnut cashew (Anacardium occidentale L.) and health markers in women climaterium	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Departamento de Nutrição e Saúde da Universidade Fedral de Viçosa	<NULL>	<NULL>	<NULL>	Women; aged 40 to 60 years; Body Mass Index classification as overweight (greater than or equal to 25 kg/m²) and obese (30 kg/m²); elevated waist circumference (greater than or equal to 80 cm for women) and excess body fat (greater than 32% for women)	Women under 40 years of age; men; body mass index lower than 30 kg/m²; athletes; shift workers; individuals with physical and/or intellectual disabilities; individuals who have undergone bariatric surgery; have experienced weight instability (5% of their usual weight) over the past three months; individuals following vegan, vegetarian, or restrictive diets (for example, gluten-free or lactose-free diets); pregnant and lactating women; patients with type 1 diabetes mellitus; autoimmune or immunosuppressive diseases (human immunodeficiency virus infection, rheumatoid arthritis, lupus); hormonal disorders (hyperthyroidism or hypothyroidism, Cushing’s syndrome); digestive diseases or disorders (gastritis, peptic ulcer disease, esophagitis, dysphagia, or chewing difficulties); individuals with inflammatory bowel diseases (ulcerative colitis, Crohn’s disease, diverticulitis, celiac disease, irritable bowel syndrome); hepatic diseases (hepatic failure, hepatitis, cirrhosis), renal diseases (chronic kidney disease), pancreatitis, cardiovascular diseases (angina, acute myocardial infarction, congestive heart failure), eating disorders (anorexia nervosa, bulimia nervosa, binge eating disorder), or cancer; history of illicit drug use and/or alcohol consumption exceeding 14 units per week; use of hormone replacement therapy; use of products enriched with prebiotics or probiotics (at least three weeks prior to screening) and use of fiber supplements (psyllium, inulin) or intake of large amounts of fermented foods (greater than 400 g/day); aversion or allergy to nuts; infectious episode in the previous month; use of anti-inflammatory drugs, corticosteroids, antibiotics, or other medications that may affect appetite and energy metabolism; habitual nut consumption exceeding 30 g/day; alcohol consumption exceeding 21 units (168 g) per week; and use of vitamin, mineral, or omega-3 supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-10j3s6pd	Cataract surgery in Glaucoma patients	Not yet recruiting	Intervention	2025-04-08	<NULL>	<NULL>	7905	Monofocal Intraocular Lens versus Monofocal-plus Intraocular Lens in Glaucoma patients: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-10j3s6pd	<NULL>	Both gender; Open angle glaucoma and angle-closure glaucoma; cataract with surgical indication; intraocular pressure lower than 21mmHg, with or without medication use; visual acuity above light perception; mild glaucoma at functional and structural evaluation	Intraocular pressure above 21mmHg; high myopia or high hyperopia; axial length above 30mm or lower than 18mm; secondary glaucomas; macular diseases; central loss at visual field; need of antiglaucomatous surgery; use of oral acetazolamide	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-46zqr8	Catheter use evaluation in peripheral vein	Recruitment completed	Intervention	2015-08-28	<NULL>	<NULL>	601	Effectiveness of peripheral venous catheter	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-04	Universidade Federal do Paraná - UFPR	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-46zqr8	<NULL>	Age between 18 and 100 years; both sexes; admitted to clinics / and / or surgical units searched the hospital; obtain peripheral venous access in the upper limbs, in gauges 20 and / or 22 gauges; prior authorization or first degree relative to participate in the study prior to venipuncture, by signing the Informed Consent and Informed.	Present fragility of peripheral venous network that prevents the puncture peripheral catheter; allergic reaction known to the material of catheters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-1066hnnx	Cavity-free city: how to keep children&apos;s teeth healthy	Recruitment completed	Intervention	2025-10-14	<NULL>	<NULL>	8408	Zero-Caries municipality: an oral health proposal for the child and adolescent population	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-1066hnnx	<NULL>	Individuals aged 6 to 16 years; presence of at least one permanent first molar with occlusal caries lesion class I classified as International Caries Detection and Assessment System 4, 5 or 6	Individuals with systemic diseases or conditions that contraindicate the proposed procedures; caries lesions classified as International Caries Detection and Assessment System 1, 2 or 3; presence of severe hypoplasia, extensive fractures or pulp necrosis in permanent molars	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-4bhmm7y	CBD/THC solution as a pharmacological strategy for patients with fibromyalgia (FibroCann)	Not yet recruiting	Intervention	2022-02-23	<NULL>	<NULL>	5328	CBD/THC solution as a pharmacological strategy for patients with fibromyalgia: single-center, double-blind, randomized, placebo controlled clinical trial protocol (FibroCann)	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-04-15	FG Brasil LTDA	3F Clinical Trials LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4bhmm7y	<NULL>	Previous diagnosis of fibromyalgia based on the pharmacological criteria of the American College of Rheumatology, 2016 to fibromyalgia, having received three months of pharmacological treatment without relevant clinical improvement; Adult individuals (aged 18 to 75 years) with a mean pain intensity greater than or equal to 7 on the FIQ numerical pain scale (Fibromyalgia  Impact Questionnaire); No use of Cannabis or its derivatives (THC and CBD) in any systemic administration route in the last six months; Capability to read, write and speak in Portuguese (Brazil); Sign the ICF (Informed Consent Form).	Pregnancy or breastfeeding; Any known pathology, in an advanced stage, associated with the locomotor system (arthritis, osteoarthritis, uric acid); Neurological disorders; Previously reported renal disorders or changes in the exams during the pre-randomization stage; Previously reported liver disorders or changes in tests during the pre-randomization stage; Peripheral neuropathy; Known serious cardiovascular disease (uncontrolled hypertension, heart failure, cardiac pacemaker); Medical decision that participation in the study is not in the best interest of the patient; Making previous use of cannabinoids by any route of administration; Diagnosis of alcohol dependence; Usage of psychotomimetic drugs or narcotics; Having participated in research projects in the two months prior to the beginning of the study; Having a history or having first-degree relatives with a history of psychosis in any level at least once in their lifetime; Inappropriate metabolic profile of THC or CBD cannabinoids for the use of the test doses in this study, observed  by pharmacogenetic testing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-55s62wd	Cell count with changes in the nucleus in individuals with Periodontitis undergoing Non-Surgical Periodontal Treatment associated or not with Antimicrobiana Photodynamic Therapy (Laser Light)	Recruitment completed	Intervention	2024-10-31	<NULL>	<NULL>	7473	Quantification of micronuclei in individuals with Periodontitis undergoing Non-Surgical Periodontal Treatment associated or not with Antimicrobial Photodynamic Therapy: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-09	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-55s62wd	<NULL>	Patient with periodontitis; over 35 years old; both genders; with 10 teeth or more in the mouth	Patients with severe motor difficulties; people with type 1 and type 2 diabetes; of chronic kidney disease; from malignant neoplasms; Acquired Immunodeficiency Syndrome; of autoimmune diseases; pregnant or breastfeeding women; immunosuppressed by medication; have evidence of other ASA III and IV systemic diseases; smokers or ex-smokers for less than ten years; users of orthodontic appliances; have a history of using steroidal or non-steroidal anti-inflammatory drugs in the previous three months and during the study; use of antibiotics in the last 4 months or any dietary supplements, including antioxidant supplements, in the last six months before the study; followed any specific diet in addition to their usual diet during the last six months and had received supra- and subgingival scaling and/or periodontal surgery in the six months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-29x2pr	Cell Therapy in Women&apos;s Health	Recruiting	Intervention	2019-05-07	<NULL>	<NULL>	2666	The use of human stem cells for the treatment of stress urinary incontinence in women.	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Paulo	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-29x2pr	<NULL>	"Inclusion criteria.
1. Patients with moderate primary and refractory stress urinary incontinence confirmed by stress cough test; or during urodynamic study; or during the pad test."	"Exclusion Criteria
Patients with prolapse of anterior or uterine vaginal wall greater than stage 2 POP-Q;
Patients submitted to surgical procedures to repair previous SUI;
Patients with genital malformations that make it impossible to inject at the site of
middle third of the urethra;
Patients submitted to previous pelvic radiotherapy;
Patients who during clinical evaluation or urodynamics present other
diagnoses that not only SUI;
Patients who did not agree to participate in the study at any stage or the ones who are not able to read, write and understand the study;
Patients &lt;18 years of age."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-4tf6mr	Cellular application analysis on communication: improvements for teaching in nursing	Data analysis completed	Intervention	2017-06-02	<NULL>	<NULL>	1250	Analysis of a learning object about therapeutic communication: contribution to teaching in nursing	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-22	Universidade Estadual do Ceará - Programa de Pós Graduação em Cuidados Clínicos em Enfermagem e Saúde	Faculdade Metropolitana da Grande Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4tf6mr	<NULL>	The student must be attending the discipline of psychological bases for the first time in the undergraduate nursing course and possessing a smartphone.	Students under the age of 18 and those who did not have basic computer skills and use of technology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-858ss8v	Cellular functional response of the musculoskeletal system of hip replacement surgery patients	Recruitment completed	Observational	2025-02-12	<NULL>	<NULL>	7736	Proliferative and functional response of the musculoskeletal system of hip Arthroplasty patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Instituto Nacional de Traumatologia e Ortopedia	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-858ss8v	<NULL>	Over 18 years; hip arthroplasty eligible; both sexes	Neoplasm; positive viral diagnosis by serology or antigen (Hepatitis B, C and HIV); indication for revision hip arthroplasty surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-45r4p9c	Ceramic Nanotubes in the Treatment of Anteroinferior Orthodontic Relapse	Recruiting	Intervention	2025-11-24	<NULL>	<NULL>	8573	Clinical application of ceramic nanotubes in the treatment of mandibular anterior orthodontic relapse: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Faculdade de Odontologia de Bauru – Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients aged between 13 and 30 years; presence of mild to moderate mandibular anterior crowding with a Little’s irregularity index greater than 2 mm; satisfactory posterior occlusion showing proper intercuspation of molars and premolars; complete permanent dentition with all teeth present at least up to the first molars; acceptable oral hygiene assessed by clinical examination; good general health	Patients with the presence of any malocclusion requiring orthodontic treatment other than anterior crowding; presence of large rotations or positional alterations of the canines; periodontal conditions that may be aggravated by labial inclination of the lower incisors; poor oral hygiene or presence of active periodontal disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:53
RBR-8ffhbk9	Cerebellar Transcranial Direct Current Stimulation and Gait Training in children with Down Syndrome	Recruiting	Intervention	2024-12-02	<NULL>	<NULL>	7552	Cerebellar Transcranial Direct Current Stimulation and Gait Training in children with Down Syndrome: a randomized, double blind controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-16	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-8ffhbk9	<NULL>	Diagnosis of Down syndrome confirmed through clinical examination and genetic investigation; age between three and eight years; both sexes; children who demonstrate sufficient response to understand simple verbal commands; no medication changes at least six months before the start of the study and during its execution; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-35xhj5	Cerebral activation and behavior of the gait of women expected to fear	Recruitment completed	Intervention	2018-09-24	<NULL>	<NULL>	2229	Cerebral mapping and biomechanical pattern of the gait of women exposed by fear off fall	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-03	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-35xhj5	<NULL>	Women 60 years of age or older; present gait with and / or without auxiliary; Mine Examination of the mental state with a score from 14 considering the influence of schooling; literate or not; who agree to participate in the study.	Use of alcoholic beverage in the last 24 hours before the exam in the laboratory; report of osteoarthrosis in the vertebral column and / or endoprosthesis in lower limbs; medical diagnosis of rheumatoid arthritis; neuromuscular or neurodegenerative disease, including diabetes mellitus; sequela of neurological disease; joint pain or edema in the last 30 days; abdominal volume that prevents the visualization of reflective markers in the pelvis; Visual impairment; body mass index (BMI) equal to or greater than 30 kg / m²; use of auxiliary devices; absence of a history of falls in the year prior to the gait assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-7fnwdr4	Cerebral stimulation in the treatment of pain due to brachial plexus nerve damage	Not yet recruiting	Intervention	2021-08-04	<NULL>	<NULL>	4811	High-definition Transcranial Direct Current Stimulation in Treatment of Neuropathic Pain After Brachial Plexus Injury: A Randomized Pilot Study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Programa de Pós-Graduação em Neurociência e Comportamento - Universidade Federal da Paraíba	Laboratório de Estudos em Envelhecimento e Neurociências - Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7fnwdr4	<NULL>	"Age between 18 and 64 years;
Score of 4 to 10 points on the Visual Analogue Scale (VAS);
Persistent pain, refractory to clinical treatment for at least 3 months, and who have received adequate pharmacological treatment for pain with an association of antidepressants, gabapentinoid antiepileptics and analgesic opioids for at least 2 months before the start of the study."	"Current pregnancy;
Contraindications for tDCS, including metallic skull implants;
Major ongoing depression, as defined by a baseline score ≥ 29 in the Beck-II Depression Inventory (BDI-II);
Previous history of alcohol or substance abuse in the last 6 months;
Use of carbamazepine in the last 6 months;
Previous history of epilepsy, stroke, moderate to severe head trauma, episodes of unexplained fainting or severe migraine;
History of neurosurgery;
Hypertrophic wounds or scars on the scalp under the placement of the electrodes."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-7h5qzf	Cerebral Stimulation with Electric Current in children and adolescents with Attention-Deficit Hyperactivity Disorder	Data analysis completed	Intervention	2018-09-13	<NULL>	<NULL>	6695	Transcranial Direct Current Stimulation in children and adolescents with Attention Deficit Hyperactivity Disorder	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-14	Faculdade de Medicina da Bahia	Faculdade de Medicina da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7h5qzf	<NULL>	right-handed; literate and inserted in regular schools; residing in Salvador or metropolitan region; without pharmacological treatment during the stimulation period; electroencephalogram without epileptogenic activity; consent of those responsible	sensory deficit; other neuropsychiatric disorders; epileptogenic discharges on the electroencephalogram	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-5rysw9w	Cerebral versus muscles adaptations promoted by two respiratory training programs in endurance–trained individuals	Data analysis completed	Intervention	2026-02-10	<NULL>	<NULL>	8855	Cerebral versus muscles adaptations promoted by two respiratory training programs in endurance–trained individuals	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Pontificia Universidad Católica do Chile	<NULL>	<NULL>	<NULL>	Age 19 to 45 years; body mass index less than 25;  absence of chronic disease or musculoskeletal injuries within the previous three months prior to enrollment; engagement in regular endurance training (at least 3 sessions per week, 30min or more per session) for at least six months prior to enrollment	Use of any legal or illegal performance–enhancing substances; acute infections or inflammatory processes within two weeks prior to initial testing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-6j752hm	Cervical manipulation and muscle and brain responses	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8017	The effect of upper cervical manipulation in physically active adults	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-6j752hm	<NULL>	Healthy male volunteers aged between 18 and 50 years; no functional limitations or medical conditions that could compromise their health or confound the study results; no abnormal fluid accumulation (edema), particularly in the lower limbs; no evidence of basilar artery impairment that would contraindicate cervical spinal manipulations	Not currently pregnant or breastfeeding; no self-reported history of neurological disorders; no reports of acute dizziness episodes; no severe visual impairments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-5tsy7yx	Chambá: an useful medicine in the treatment of high blood pressure?	Not yet recruiting	Intervention	2021-05-27	<NULL>	<NULL>	4682	Evaluation of JP002 in the treatment of individuals with Hypertension: randomized, double-blind, placebo-controlled clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-07-05	Faculdade de Medicina de Ribeirão Preto -USP	Faculdade de Medicina de Ribeirão Preto -USP	https://ensaiosclinicos.gov.br/rg/RBR-5tsy7yx	<NULL>	Men, non-pregnant women, older than 12 years old and less than or equal to 80 years old, diagnosed with Hypertension and on at least monotherapy regimen for this disease.	Pregnant or lactating women; hypertension due to secondary cause; coagulopathies; individuals who use any other herbal medicine during the study; individuals who have a serious adverse reaction to the medication, individuals who request their withdrawal from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-2jfwqx	Change in effort capacity and life quality after pulmonary reabilitation in pre lung trasplantation patients /Clinics Hospital of Universidade Federal de Minas Gerais	Recruitment completed	Intervention	2019-03-25	<NULL>	<NULL>	2538	Chande in six minutes walk test and life quality after pulmonary reabilitation in lung trasplantation patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-05-18	Hospital das Clínicas UFMG	Hospital das Clínicas UFMG	https://ensaiosclinicos.gov.br/rg/RBR-2jfwqx	<NULL>	"It must be stable from a clinical point of view.
Be motivated to participate in the program.
Be free of lung infection at the time of starting the program.
There must be no other disabling condition limiting your participation in the program.
Must be receiving medical follow-up and release for inclusion in the program."	"Be clinically unstable.
Being unmotivated to participate in the program.
Being with pulmonary infection at the time of starting the program.
Having another disabling condition that limits your participation in the program (musculoskeletal disease that prevents exercise, decompensated heart failure, uncontrolled hypertension).
Not having medical follow-up and release of it for inclusion in the program."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-10p7wv9y	Change in electrical properties of leg muscle by stimulation of Systemic Acupuncture points	Not yet recruiting	Intervention	2023-10-05	<NULL>	<NULL>	7081	Change Dielectric Constant by stimulation of Systemic and Auricular Acupuncture points	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-30	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10p7wv9y	<NULL>	Healthy volunteers; both genders; age between 18 and 38 years	Fear of needles; pregnant women; women with delay in menstrual cycle longer than 28 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-2dx9m4h	Change in grip strength induced by overflow contralateral to hip flexion	Data analysis completed	Intervention	2025-05-03	<NULL>	<NULL>	7980	Change in grip strength induced by overflow contralateral to hip flexion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2dx9m4h	<NULL>	They were aged between 18 and 30 and had a motor preference for the right upper limb.	Volunteers with orthopaedic alterations, pain, difficulty in performing the palmar grasp and hip flexion movements, and failure to achieve at least 70 per cent of the maximum hip flexion force.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-35xrwf	Change in the chest and blood pressure after exercise the muscle of respiration of patients with lung problem	Data analysis completed	Intervention	2015-04-06	<NULL>	<NULL>	435	Biomechanical and hemodynamic changes in patients with COPD treated with transcutaneous electrical stimulation diaphragmatic	<NULL>	0, single-arm-study, open	0	<NULL>	<NULL>	<NULL>	2010-07-31	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-35xrwf	<NULL>	Drug stability;smoking cessation; Classification COPD grade III  and IV; maintenance lifestyle; men and women; aged 18 to 80 years.	Metallic prosthesis; pacemaker; dermal injury.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-79c83z	Change of lifestyle in women with breast cancer	Recruitment completed	Intervention	2019-04-26	<NULL>	<NULL>	2639	Evaluation of change lifestyle in women with Breast Cancer, through Quality of Life, Depression, Function, Nutrition appraisal and evaluation Biological Mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-15	Universidade Federal de Minas Gerais	Instituto de Previdência dos Servidores do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-79c83z	<NULL>	patients with breast cancer until one year after diagnostic in ambulatory treatment and all the treatment can practice exercise and answer the questionnaire	patient can´t practie exercise and can´t answer the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-7hsjfjk	Changes in body fat and muscle mass in overweight adolescents and genetic predisposition to obesity, submitted to different physical exercise programs	Data analysis completed	Intervention	2021-06-17	<NULL>	<NULL>	4753	"Body composition and Genetic assessments in Overweight adolescents and young people
and Obese, submitted to different Physical Activity Programs"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Federal de São João del Rei	Universidade Federal de São João del Rei	https://ensaiosclinicos.gov.br/rg/RBR-7hsjfjk	<NULL>	Adolescents characterized as overweight and obese, aged between 15 to 19 years old, enrolled in the state public school system, in morning, afternoon or night shifts; agree to participate in the study, by presenting a Free and Informed Consent Form (TCLE) signed by parents and / or guardians (when minors) or by the volunteer (when over 18); underage individuals should sign the Informed Consent Form.	Unavailability to participate in evaluations or unable to attend School Physical Education classes; presentation of an injury picture (before or during the intervention program) that would permanently disable them to practice the exercises; maximum limit of 20% of consecutive absences in the intervention program; unavailability to participate in the stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-5mvjqt	Changes in DNA (epigenetics) and in the behavioral, emotional and conscience aspects of women with painful Temporomandibular Disorders before and after a Mindfulness program	Suspended	Intervention	2020-10-04	<NULL>	<NULL>	4326	Differentiation in global dna methillation, snp polymorphisms and cognitive-behavior-emotional involvement of women with chronic painful Tmd before and after Mindfulness intervention	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-03-09	Universidade de São Paulo-Faculdade de Filosofia Ciências e Letras de Ribeirão Preto	Universidade de São Paulo Escola de Enfermagem de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5mvjqt	<NULL>	Volunteer women; age between 18 and 45 years; diagnosis of painful TMD for more than 3 months.	Volunteers undergoing any type of treatment for painful Temporomandibular Dysfunction; previous history of tumors; previous history of trauma or head and neck surgery; presence of neurological disorders; presence of psychiatric disorders; volunteers who use controlled medications, such as anxiolytics, antidepressants and anticonvulsants; pregnant volunteers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-7q2bh3r	Changes in fatigue after a exercise program in individuals with Long Covid and persistent fatigue	Recruiting	Intervention	2025-10-10	<NULL>	<NULL>	8388	Modifications in perceived and performance fatigability induced by a combined exercise intervention in patients with Long COVID and persistent fatigue	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-04	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-7q2bh3r	<NULL>	People who were diagnosed with COVID-19 by RT-PCR. Aged ≥18 years, of both sexes. Who report fatigue as a symptom for at least 12 weeks since the COVID-19 infection.	Pregnant women, hospitalized individuals, people with disabilities who are unable to perform the proposed tests and exercises. Individuals with cognitive impairments that prevent understanding or performing the tests, those with uncontrolled chronic diseases, and those with medical contraindications to physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-85vmkx	Changes in functional exercise functional capacity, body composition and quality of life of menopausal women	Recruitment completed	Intervention	2014-07-30	<NULL>	<NULL>	321	Changes of a physical activity program based on the protocol of functional training on functional abilities, body composition and quality of life of menopausal women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-10	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-85vmkx	<NULL>	Female volunteers, aged between 45 and 65 years; present in the menopausal period without menstruation for 1 year or more; possess a medical certificate to perform the tests required and participate in the training program	Present physical limitations or any health problems that prevent the implementation of the evaluation or bodily practices, accumulate three consecutive unexcused absences or 4 unexcused absences during the month of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-3dgmggm	Changes in functional mobility and brain activity after Task-Oriented Intensive Treatment in children and adolescents with Cerebral Palsy	Recruiting	Intervention	2022-10-18	<NULL>	<NULL>	5773	Neural and biomechanical mechanisms associated with changes in functional mobility after an Intensive Task-Oriented Training protocol in children and adolescents with Cerebral Palsy	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3dgmggm	<NULL>	Diagnosis of cerebral palsy; ages 7 to 16 years; both genders; Gross Motor Function Classification System (GMFCS) levels I to III; who are able to understand and complete the instructions; inform consent	Uncontrollable seizures; severe visual and / or cognitive problems; children who have undergone orthopedic or neurological surgery or botulinum toxin application 6 months before or during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-9k7s9j	Changes in Heart Rate and Benefits of an  Exercise Training Carried Out During Hemodialysis in Intensive Care Unit Patients (ICU)	Not yet recruiting	Intervention	2013-04-19	<NULL>	<NULL>	181	Hemodynamic Effects of Physical Activity in Critically Ill Patients During Hemodialysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-05-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9k7s9j	<NULL>	Hemodynamical stability, hemoglobin &gt; 6 g/dl and lower limb problems that precluded exercise (for example leg bone tumor, deep vein thrombosis).	Catheter positioned in arterial femoral site.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-6qw5sp	Changes in heart rate and immediate blood pressure and after different protocols of breathing exercises in patients with Chagas&apos; heart disease.	Recruitment completed	Intervention	2020-01-07	<NULL>	<NULL>	3338	Acute and subacute hemodynamic changes in individuals with chronic chagasic cardiopathy submitted to different respiratory muscular training protocols - Clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Instituto Nacional de Infectologia Evandro Chagas	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-6qw5sp	<NULL>	Male and female gender; be over 18 years old; having stage B2 and C chagasic heart disease; be in regular follow-up at the Chagas disease outpatient clinic of the Evandro Chagas National Institute of Infectious Diseases (INI).	Clinically decompensated individuals; who have chronic lung disease; who have atrial fibrillation; pacemaker carriers; who present some clinical limitation that contraindicates the performance of the proposed exercise protocol; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4xdkq4	Changes in muscle strength in elderly women after Kabat based training	Data analysis completed	Intervention	2013-10-08	<NULL>	<NULL>	256	Analysis of change in muscle conditioning before and after Kabat Proprioceptive Neuromuscular Facilitation based training in a elderly population	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4xdkq4	<NULL>	Women, physically active, aged between 60 and 70 years, healthy, no history of surgery or chronic pathologies such as systemic arterial hypertension and diabetes.	Suffering from chronic diseases of any kind; history of surgery; sedentary, they do not agree with the terms of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-8ghk566	Changes in nasal obstruction in adolescents with allergic rhinitis after laser use	Recruitment completed	Intervention	2023-11-15	<NULL>	<NULL>	6574	Effects of photobiostimulation with red and infrared laser on nasal obstruction in adolescents with allergic rhinitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Escola Paulista de Medicina	Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-8ghk566	<NULL>	Age between 8 and 17 years old, medical diagnosis of RA (ARIA) present in the medical record for at least 12 months; allergic sensitization by immediate reading skin test (Prick test) or specific serum IgE to at least one inhaled allergen in the last 12 months; degree of nasal obstruction with values equal to five on the day of the test on a visual analogue scale (5 to 10).	Severe or uncontrolled asthma; use of topical medication (nasal decongestant in the last 24 hours); topical corticosteroids within two weeks; use of oral medication: systemic corticosteroids within the last four weeks,chromones within d weeks, antihistamines within a week or immunotherapy five years before the start of the study; severe systemic disease; history or signs of upper or lower respiratory infection within the last four weeks; anatomical defects of the upper airways (nasal polyposis, adenoid hypertrophy, deviated septum, tumor mass) documented in the medical record or observed on physical examination; maxillary atresia; history of epistaxis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-9bhbrp	Changes in oxygenation of skin and muscles after the use of Functional Bandage in women with Varicose Veins	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1934	Kinesio Taping use in tissue oxygenation in women with Chronic Venous Insufficiency: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-14	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9bhbrp	<NULL>	Must be female, be between 30 and 79 years old and present the diagnosis of chronic venous insufficiency (confirmed by Duplex Scan) or classified in stages C1, C2 or C3 of CEAP. To be included in the study the participants may not be on hormone replacement therapy and may not have symptoms of intermittent claudication, lymphedema, diagnosis of thrombosis for less than three months, heart failure, and no other type of conservative treatment for IVC, or have undergone sclerotherapy or surgery in the past three months. In addition, they can not present any contraindication to the use of KT such as open sores, trauma, edema arising from heart or kidney disease, cancer, KT allergy, and pregnancy. All participants must agree to participate in the research by signing the Informed Consent Term.	Participants who present knesio taping allergy or intolerance will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-7jwxqd	Changes in the energy channels of Acupuncture in patients with Spinal Cord Injury, and possible correlations with the ASIA Neurological Assessment Scale	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3742	Energy Profile with Ryodoraku Acupuncture Electrodiagnosis in patients with Spinal Cord Injury and possible correlations with the ASIA Scale	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-31	Faculdade de Tecnologia IBRATE	Faculdade de Tecnologia IBRATE	https://ensaiosclinicos.gov.br/rg/RBR-7jwxqd	<NULL>	Participants were recruited from patients who attended the neurological physiotherapy service at hospital da universidade estadual de londrina . The inclusion criterion was to present spinal cord injury of the spastic or flaccid paraplegia type, older than 18 years of age, not to have lesions or dermatological changes in the wrist and ankle regions (places of inspection of the technique). Both sexes; races; religion and color were included.	To have a pacemaker. Individuals with quadriplegia and paraparesis; pregnant women were exclude	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7yygb2	Changes in tissue electrical resistance as an indicator of radiotherapy-induced tissue alterations	Terminated	Intervention	2018-09-18	<NULL>	<NULL>	7752	Alteration of tissue electrical resistance as a marker of Lesions Caused by Radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-19	André Luiz Sena Guimarães	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-7yygb2	<NULL>	The criteria for inclusion in the study covered adults over 18 years of age of both sexes with a confirmed histopathological diagnosis of head and neck squamous cell carcinoma (HNSCC) in locations such as the base of the tongue, other or unspecified parts of the tongue, gums, floor of the mouth, palate, other parts or unspecified parts of the mouth, tonsils, oropharynx, pyriform sinus, hypopharynx and other ill-defined locations in the lip, oral cavity or pharynx, as well as patients with a confirmed histopathological diagnosis of other types of cancer in regions such as the prostate, urinary bladder, rectum, anus, breast and cervix, including prostate adenocarcinoma, metastasis in other organs of the urinary system, carcinoma in situ of the prostate , penile cancer, squamous cell carcinoma of the anal canal, squamous cell carcinoma of the cervix, adenocarcinoma of the cervix, esophageal cancer, ductal carcinoma in situ of the breast or others specified or unspecified malignant neoplasms. All participants, regardless of cancer type, were receiving 3D conformal radiotherapy (3D-RT), alone or in combination with chemotherapy	patients who had already undergone radiotherapy for head and neck cancer; presence of oral mucositis at the beginning of the study; use of pacemakers; refusal to participate; history of alcohol or drug abuse; diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic diseaes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3w3sry	Changes in vital signs, according to the position of the belly up, belly down, and kangaroo, in newborns admitted to the Neonatal ICU	Recruitment completed	Intervention	2020-04-01	<NULL>	<NULL>	3695	Changes in heart rate, respiratory rate and peripheral oxygen saturation, according to the supine, prone and kangaroo positions, in newborns admitted to the Neonatal ICU	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-19	Universidade Federal do Parana	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3w3sry	<NULL>	Newborns with gestational age between thirty and thirty-seven weeks; weighing between 1000 and 1499 gr; of both sexes; under spontaneous breathing; clinically stabl;, admitted to the Neonatal ICU of Hospital de Clínicas da UFPR and can be manipulated to different positions (prone, supine and kangaroo)	Newborns in invasive and noninvasive mechanical ventilation; if not in the appropriate size and weight range; if the mother is unable to perform the kangaroo method if this is the posture to be evaluated in the child; not being in the unit intensive care where research is being conducted; not having parental authorization; being unstable and / or unable to handle at the time of the assessment; being in palliative care; having performed thoracoabdominal surgeries that make handling and positioning impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-92mmc7	Changes in vitamin D metabolism in HIV-infected patients.	Recruitment completed	Intervention	2015-08-14	<NULL>	<NULL>	582	Vitamin D, Immune Activation and Metabolic Changes in HIV-Infected Patients using Antiretroviral Therapy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-22	Insituto Nacional de Infectologia Evandro Chagas/Instituto de Pesquisa Clinica Evandro Chagas	Insituto Nacional de Infectologia Evandro Chagas/Instituto de Pesquisa Clinica Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-92mmc7	<NULL>	HIV-infected men and women aged 18 years or more; having HIV-1 RNA &lt; 50 copies / mL proven with their current antiretroviral regimen (within the 24 weeks prior to study entry); participants should receive HIV primary care in the Evandro Chagas Research Institute (IPEC) at the time to study entry; participants should have capacity and willingness to sign the written informed consent prior to the initiation of the study procedures.	Persons receiving vitamin D supplementation &gt; (not including standard multivitamin once a day);  HIV-infected persons not in use antiretroviral therapy; HIV-infected persons without viral suppression with their current antiretroviral regimen (HIV-1 RNA&gt; 50 copies/mL within the 6 months prior to screening).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-9qsgdqr	Changes in VO2max and oxidative metabolism in different quadriceps muscles during 6 weeks of moderate continuous intensity training and high intensity interval training: a randomized crossover trial	Recruitment completed	Intervention	2025-04-09	<NULL>	<NULL>	7908	Changes in VO2max and oxidative metabolism in different quadriceps muscles during 6 weeks of moderate-intensity continuous training and high-intensity interval training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9qsgdqr	<NULL>	Be at least 18 years of age; to be of the masculine gender; have participated in at least three sessions of physical activity per week, on average, in the month leading up to the start of the study	Use of medications that could potentially interfere with the study results; smokers; participants who answered &quot;yes&quot; to any question on the physical activity readiness questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-6msdqt	Changing the traumatized patient&apos;memory with Prolonged Exposure Therapy	Data analysis completed	Intervention	2019-03-04	<NULL>	<NULL>	2509	Post-exposure retrieval in the traumatized patient	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-15	Fundação de Amparo à Pesquisa do Estado de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6msdqt	<NULL>	Meet the DSM-IV criteria for PTSD according to the Structured Clinical Interview for DSM Axis I Disorders, Patient Edition (SCID-I/P); being able to report the traumatic event; have emotional reactivity to trauma recall, defined as a minimum score of 40 in the Visual Analogue Scales (VASs) after describing the traumatic event; have regular menstrual cycle (female patients who were then tested in the follicular phase, defined as the first half of their usual cycle) or were taking hormonal contraceptive.	Patients were excluded if they had any medical condition that could threaten their safety, such as heart or neurological conditions, or current suicide risk; fulfill criteria for bipolar, psychotic, or substance use disorders; were in use of medications known to affect memory reconsolidation or extinction, such as beta-adrenergic blockers, benzodiazepines and anticonvulsants; current pregnancy; and previous participation in another study that could affect the present one.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-3vs3gh8	Characteristics of COVID-19 patients using masks that help to breathe in a hospital in Rio de Janeiro	Recruiting	Observational	2022-09-08	<NULL>	<NULL>	5599	Profile of patients with SARS-COV-2 under Non-Invasive Ventilatory Support in a tertiary hospital in Rio de Janeiro: a retrospective observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-22	instituto de biofisica carlos chagas filho	instituto de pesquisa e ensino d'or - IDOR	https://ensaiosclinicos.gov.br/rg/RBR-3vs3gh8	<NULL>	Adult patients; 18 years of age and older; admitted to the ICU with COVID-19 confirmed via positive RT-PCR or CT scan suggestive of pneumonia caused by COVID-19	Estimated length of hospital stay less than 3 days; Patients who progressed to orotracheal intubation in less than 48 hours of hospital stay; Patients whose non-invasive ventilatory therapy has lasted less than 48 hours; Patients whose medical records lack predictive and outcome variables	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3qzk3nw	Characteristics of root canal instrumentation with enlargement of the apical foramen	Recruiting	Intervention	2024-04-15	<NULL>	<NULL>	6936	Morphological, microbiological and immunological characteristics of foraminal enlargement: randomized clinical trial and ex vivo study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3qzk3nw	<NULL>	Patients aged 18 years or over; of both sexes; diagnosed with pulp necrosis and apical periodontitis in upper or lower first and/or second molars	Use of some antibiotics and anti-inflammatory drugs in the three months before endodontic therapy; those who have already started instrumentation of the canals previously and/or present concomitant periodontal involvement in the tooth in question; teeth with root fractures, fused roots, incomplete rhizogenesis, wide foramina whose initial apical instrument in the MV canal is greater than K #20	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-6jqp52	Characterizantion of food habits in women with Facial pain	Recruiting	Observational	2019-11-27	<NULL>	<NULL>	3232	Characterizantion of food habits in women with Temporomandibular joint disorders (rdc/tmd)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-06-05	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6jqp52	<NULL>	"The sample will be composed of women aged between 18 and 55 years old; who have no loss of more than five dental elements;
maladaptive prostheses; moderate to severe periodontal disease; dental or intraoral or extraoral lesions that may compromise the function
chewing. Will also be included in the sample women with orofacial pain; but can not have other painful disorders
chronic diseases; food intolerances and other systemic conditions that may lead to food restriction."	"Participants with cognitive impairment that precludes their participation in the study; as well as those who do not accept to participate
or leave after inclusion, will be deleted."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7tnhd8	Characterization of grisp strenth and manul skills of children with 5 to 10 years with Down syndrome.	Recruiting	Intervention	2016-05-31	<NULL>	<NULL>	876	Characterization of grisp strenth and manual dexterity of children with 5 to 10 years with Down syndrome.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-19	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7tnhd8	<NULL>	"The child must be between 5-10 years and 11 months old; parents have signed a consent form freely Clarified and child Consent Term freely Clarified, the child has a diagnosis of Down syndrome.

The child must be between 5 to 10 years and 11 months old; parents have signed a consent form freely Clarified the child take part in the research by signing the Instrument of Consent Informed freely; the child is typically developing, presenting school grades above average (5.0) in two consecutive marking periods in the subjects of English Language, Mathematics and Physical Education; considered good students for the newsletter description given by school teachers / the classroom, be enrolled and attending regular network of public or private education."	"The child is less than five years or over 10 years and 11 months; parents / guardians and the child does not agree to participate in the survey; have different diagnoses of Down syndrome, present co-occurrences of diseases that are not characteristic of Down syndrome according to the guidelines of care for people with Down syndrome (MINISTRY OF HEALTH, 2013).


The child is less than five years or over 10 years and 11 months; parents / guardians and the child does not agree to participate in the survey; children have any involvement in its development or have a diagnosis that harms their performance in this study, such as learning disorders, syndromes, cerebral palsy, as well as having a history of prematurity and orthopedic surgeries in the upper limbs and are taking medicine which might jeopardize the manual skill of the child, such as psychotropic drugs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-4wwj5c	Characterization of heartbeat and motor functions in people with spinal cord injury	Recruiting	Intervention	2019-05-06	<NULL>	<NULL>	2663	Characterization of autonomical modulation and the functional profile of people with spinal cord injury	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4wwj5c	<NULL>	All patients who are in clinical follow-up at Acreditando, Neuromotor Recovery, Health and Welfare Center and carrying the authorization of parents or guardians to participate in the study, with medical diagnosis of spinal cord injury, will be considered eligible.	Patients with cardiac arrhythmias and atrioventricular block, congenital anomalies, such as congenital heart diseases, pulmonary malformations, and patients using drugs that interfere with autonomous nervous system, such as antiarrhythmic drugs and drugs for the treatment of diabetes mellitus, such as insulin, will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-10367s7j	Characterization of Infrared Thermography of the masticatory muscles in normal people and people with Temporomandibular Disorder	Recruiting	Observational	2024-10-28	<NULL>	<NULL>	7460	Thermographic Characterization of the mastigatory muscles in normal individuals and with Temporomandibular  Dysfunction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-26	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-10367s7j	<NULL>	individuals between 20 and 50 years old; without Temporomandibular disorders; patients with Temporomandibular disorders of both sexes	history of trauma to the face or Temporomandibular joints; systemic disease; arthritis;  osteoarthritis; neuromuscular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-9x6yxbv	Characterization of patients and evaluation of drug treatment for Multiple Sclerosis	Data analysis completed	Observational	2021-12-29	<NULL>	<NULL>	7986	Epidemiology and oral disease-modifying therapies for Multiple Sclerosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9x6yxbv	<NULL>	Individuals over 18 years of age; of both sexes; diagnosed with Multiple Sclerosis represented by the G-35 code, which encompasses the group of diseases of the nervous system in the 10th edition of the International Statistical Classification of Diseases and Related Health Problems (ICD 10); assisted by the Specialized component of the Pharmaceutical Assistance of Mato Grosso do Sul; undergoing treatment, for at least three months, with one of the following oral administration medications: Teriflunomide 14mg, Dimethyl fumarate 240mg or Fingolimod 0.5mg; with at least one result of the Expanded Disability Status Scale (EDSS) prior to and one subsequent to the initiation of treatment with the oral medications described above	Individuals with cognitive alterations that make it difficult to remember facts related to their illness; individuals with cognitive alterations that make it difficult to understand the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-88djbyd	Characterization of plant food compounds in breast milk	Recruitment completed	Observational	2024-08-06	<NULL>	<NULL>	7179	Characterization of phenolic compounds in human breast milk	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-88djbyd	<NULL>	Lactating women; primiparous and multiparous;  mothers of full-term or premature babies; aged between 18 and 40 years; Body Mass Index - BMI between 18.5kg/m2 and 39.9kg/m2; with single or multiple (twin) pregnancies; who are breastfeeding exclusively or partially	The use of medications or therapies that influence lactogenesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-4j5g96	Characterization of the patient with painful click in the jaw joint.	Data analysis completed	Observational	2020-06-15	<NULL>	<NULL>	3921	Clinical, somatosensory and psychosocial characterization of patients with painful temporomandibular joint clicking: a cross-section study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	FACULDADE DE ODONTLOGIA DE BAURU	FACULDADE DE ODONTLOGIA DE BAURU	https://ensaiosclinicos.gov.br/rg/RBR-4j5g96	<NULL>	Volunteers with complaints of clicking and pain or just clicking on the temporomandibular joint; both genders; age between 18 and 70 years.	Volunteers with different clicking noises; individuals with complaints of non-articular pain; patients with a known diagnosis of degenerative joint diseases; patients who had undergone previous surgery of the temporomandibular joint; individuals under the influence of analgesic, anti-inflammatory, antidepressant, anticonvulsant and benzodiazepine medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-42c6gz	Characterization of trigger points in the rectus abdominis muscle in women with chronic pelvic pain using electromyography.	Data analysis completed	Observational	2014-11-05	<NULL>	<NULL>	345	Characterization of local mechanisms (trigger points) of abdominal myofascial syndrome in women with chronic pelvic pain using surface and needle electromyography.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-09-19	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto	Departamento de Ginecologia e Obstetrícia - Comissão de Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-42c6gz	<NULL>	Women with chronic pelvic pain; age over 18 years; presence of all clinical diagnostic criteria for abdominal myofascial pain syndrome.	Women with typical clinical symptoms of endometriosis or painful bladder syndrome or irritable bowel syndrome or other disease that justify or contribute to chronic pelvic pain; endometrioma or hernia evidenced by ultrasound of abdominal wall; obesity (BMI &gt; 30 kg/m²); use of anticoagulant; coagulation disturbance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-6n5wq43	Chemical characterization of grains, flours and sorghum-based products and impact of consumption on human health	Recruitment completed	Intervention	2023-08-09	<NULL>	<NULL>	6322	Chemical characterization and bioactive compounds of grains, flours and products based on new genotypes of sorghum and the impact of consumption on human health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-6n5wq43	<NULL>	male, aged between 18 and 40 years; body mass index (BMI) ≥ 27.0 and ≤ 34.9 kg/m²; waist circumference ≥ 90 cm; fasting capillary blood glucose ≥ 70 and ≤99 mg/dL; capillary cholesterol &lt; 240 mg/dL; capillary triglyceride &lt; 150 mg/dL.	diabetic individuals or individuals with a family history of diabetes or glucose intolerance; patients with chronic and/or acute illnesses; alcoholics and/or smokers; who make regular use of anti-inflammatory drugs, corticoids, antibiotics or that affect appetite and/or energy, lipid and glucose metabolism; who are using a dietary fiber supplement; who had infectious or allergic episodes in the last 3 months; who have an aversion or allergy to sorghum; who are lactose or gluten intolerant; who have undergone a diet for weight loss or have fluctuated in weight greater than ± 5 kg in the last 3 months; that you do not consume the test preparations for more than 6 days (consecutive or not) in each intervention period; and show any adverse effect that prevents you from continuing the study or demonstrate a desire not to continue participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-9xnf8r	Chemistry evaluation and patients satisfaction in relation to carbamide peroxide bleaching gels: clinical trial	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2862	Evaluation of degradation, pH and patient satisfaction with 20-22% carbamide peroxide gel flavour in at-home bleaching: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-13	Instituto de Ciência e Tecnologia de São José dos Campos	Instituto de Ciência e Tecnologia de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-9xnf8r	<NULL>	minimum of 18 years old; good general health; patients who want to retouching of bleached teeth (bleaching treatment previously); abscence of gingival recession, non carious cervical lesion, active carie or periodontal disease; do not use fixed orthodontic appliances or removable prosthesis; pressent all teeth upper and lower sencond premolars; and avaiability for recurring returns	Chemical dependents, smokers ou alcoholics; medical conditions in which can interfere in volunteer security (medicines for the treatment of chronic diseases or allergic reactions to substances to be used); pregnancy; be in another study in the same period; present bruxism, periapical alterations ou tooth sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-7bxhrt	Chemoprophylaxis with chloroquine in a high-risk population for the prevention of SARS-CoV-2 infections  severity of infection.	Recruiting	Intervention	2020-07-14	<NULL>	<NULL>	4008	"Chloroquine chemoprophylaxis in a high-risk population for the prevention of SARS-CoV-2 infections severity of infection. Randomized clinical trial of
phase III"	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-05-25	Instituto René Rachou/FIOCRUZ Minas	Centro de Pesquisa Clínica do Hospital das Clinicas (UFMG)	https://ensaiosclinicos.gov.br/rg/RBR-7bxhrt	<NULL>	"Health professionals attending patients with suspected SARS-CoV-2 infection.
sign the informed consent.
Willing to adhere to the study protocol."	"Known allergy to the study drug (aminoquinolines).
flu-related symptoms at the time of inclusion.
Previous or current SARS-Cov2 infection confirmed.
Known pregnancy (no pregnancy test required).
History of retinopathy.
ECG changes with enlargement of the QT interval.
Weight less than 40 kg
Participant with any immunosuppressive condition or hematological disease.
Treatment with drugs that can prolong the QT interval or increase the number of adverse events in the last month before randomization for more than 7 days, including: azithromycin, chlorpromazine, cisapride, clarithromycin, domperidone, droperidol, erythromycin, halofantrine, haloperidol, lumefantrine, mefloquine, methadone, pentamidine, procainamide, cimetidine, quinidine, quinine, sotalol, sparfloxacin, thioridazine, amiodarone, Dapsone"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-5j3j9z9	Chemoradiation and Consolidation Chemotherapy with or without oxaliplatin for distal rectal cancer and Watch and Wait. A multi-center prospective randomized controlled trial. (CCHOWW)	Not yet recruiting	Intervention	2021-02-10	<NULL>	<NULL>	4539	Chemoradiation and Consolidation Chemotherapy with or without oxaliplatin for distal rectal cancer and Watch and Wait. A multi-center prospective randomized controlled trial. (CCHOWW)	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-04-01	Hospital Alemão Oswaldo Cruz	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-5j3j9z9	<NULL>	"1.	Age ≥18 years;
2.	ECOG 0-2 or KPS≥70;
3.	Primary rectal adenocarcinoma (biopsy confirmed) within the reach of digital rectal examination (at least lower tip/border) by the attending colorectal surgeon;
4.	Endoscopic documentation;
5.	Abdominal and chest CT scans showing no evidence of metastatic disease;
6.	High-resolution magnetic resonance images performed at either 1.5T or 3.0T system using a phased array surface coil with: sagittal T2 images including the anal verge and the sacrum; axial oblique T2 weighted images acquired in a plane perpendicular to the long axis of the rectal wall guided by the sagittal images; coronal images acquired in parallel to the anal canal plane. Small field of view (16-18cm), 3mm section thickness, increased matrix size and increased number of signal averages are required;
7.	Radiological defining criteria (centralized):
a.	Lower edge of tumor at the level (max. 1cm distance) or below the anorectal ring defined at sagittal or coronal views;
b.	mrT2, mrT3 (any subclassification) 
c.	mrN0-1 (≤3 radiologically positive lymph nodes)
d.	mrEMVI: any status
e.	mrMRF: any status"	"1.	Pregnancy
2.	ECOG ≥3 or KPS&lt;70
3.	Unwilling to consent
4.	Metastatic disease (any kind; internal iliac and obturator nodes are considered local disease and not metastatic disease and therefore will not be considered as exclusion criteria)
5.	mrT4 or mrN2
6.	Previous pelvic irradiation
7.	Baseline neuropathy
8.	Receiving treatment of other anti-cancer drug or methods
9.	Presence of uncontrolled life threatening diseases"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-6rgr4gp	Chest physiotherapy in infants with Acute Viral Bronchiolitis	Data analysis completed	Intervention	2024-09-23	<NULL>	<NULL>	7366	Phydiotherapeutic intervention in infants with Viral Bronchiolits moderate acute	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-19	Complexo do Hospital de Clínicas da Universidade Federal do Paraná	Complexo do Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6rgr4gp	<NULL>	Infant patients; of both sexes; from 1 day of life to 12 months of age; admitted to the pediatric wards at the Hospital de Clínicas do Complexo Hospital de Clínicas; with no history of hospitalizations; with a clinical diagnosis and classified as moderate in the Acute Viral Bronchioitis score; which guardians agree to adhere to the Informed Consent Form	Infants who present hemodynamic instability; classified as mild or severe in bronchiolitis scores; prematurity; lung malformation; bronchopneumonia; congenital heart defects; with a history of hospitalizations for other pathologies; refusal of family members or guardians and failure to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-4bghjg	Chewing Gum for Caries Treatment	Recruiting	Intervention	2019-01-14	<NULL>	<NULL>	2441	Evaluation of the Use of a Chewing Gum containing Natural Products on the Salivary Concentrations of Streptococcus mutans in Childrens	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4bghjg	<NULL>	"Children of both sexes;
No history of allergic reactions;
Aged between 5 and 12 years;
With normal pattern of growth and development;
Patients who have not undergone dental treatment during the last six months;
Children with caries (presence of at least one lesion of active caries, cavitated or not cavitated)."	"Patients with a history of allergies (asthma, urticaria, rhinitis, sinusitis);
Patients with a history of allergies to medicines, foods or other factors;
Patients with a history of chronic diseases, congenital or any systemic alterations;
Patients with a history of gastrointestinal, hepatic or renal disease;
Patients who have undergone antibiotic treatment up to six months prior to the survey;
Patients with soft tissue lesions in the oral cavity;
Patients whose parents or legal guardians refuse to sign the free and informed consent form;
Children free of carious lesions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-5v5bvw	Chewing in Alzheimer&apos;s Disease	Recruiting	Observational	2015-11-09	<NULL>	<NULL>	649	Chewing function in Alzheimer&apos;s Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-12-06	Faculdade de Odontologia de Piracicaba - UNICAMP	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-5v5bvw	<NULL>	"Experimental group: elderly patients with mild Alzheimer&apos;s Disease, totaly or partially edentulous, removable prosthesis wearers.
Control Group: elderly patients with the absence of any type of dementia, totaly or partially edentulous, removable prosthesis wearers."	"Experimental group: the presence of cognitive-behavioral disease different from Alzheimer&apos;s dementia, motor disturbances which make impossible appliying the tests, presence of signs and symptoms of bruxism.
Control group: presence of any kind of dementia or cognitive behavioral disease, movement disorders which make impossible appliying the tests, presence of signs and symptoms of bruxism."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-10crngzr	Chiari malformation type I treatment: comparison between Resection of Filum Terminale  and Posterior Fossa Decompression	Recruiting	Intervention	2026-01-05	<NULL>	<NULL>	8692	Evaluation of patient-reported outcome in the treatment of Chiari Malformation type I in adults without tethered cord with Resection of the Filum Terminale versus Posterior Fossa Decompression: randomized non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-01	Hospital Universitário Onofre Lopes	<NULL>	<NULL>	<NULL>	age over 18 on the day of recruitment; have a radiological diagnosis of Chiari type I without tethered cord and clinical symptoms resulting from Chiari; free informed consent to participate in the study	Exclusion criteria will be: being under 18 years of age, failure to agree to a free and informed consent form, presence of radiological signs of tethered spinal cord, and diagnosis of psychiatric illness without regular treatment, since pre- and post-operative evaluations will include subjective complaints. Presence of symptoms or radiological signs of tethered spinal cord; diagnosis of psychiatric illness without regular treatment, since pre- and post-operative evaluations will include subjective complaints; previous neurological or spinal surgeries.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-3m6gnj	Chicken Burger with Flaxseed and its Effect on Appetite and Blood Glucose	Recruiting	Intervention	2018-12-01	<NULL>	<NULL>	2354	Nutritional, Sensory Value of Chicken Burgers Prepared with Flaxseed Flour and its Effects on Appetite, Food Intake and Postprandial Glycemia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Universidade Federal Rural do Rio de Janeiro	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais-Campus Rio Pomba	https://ensaiosclinicos.gov.br/rg/RBR-3m6gnj	<NULL>	eutrophic; normoglycemic; not taking medications known to affect glycemia, fat metabolism, or appetite; no body weight fluctuation ( greather than 5kg) in the past 3 months.	Smokers, consumption of more than two doses of alcohol ((greather than 20 mL) per day, type 1 or 2 diabetic or glucose intolerant, family history of type 1 or type 2 diabetes, recent changes (within less than three months) in diet or physical activity habits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-8t9bqkg	Children with Developmental Coordination Disorder: relationships and predictors of motor deficits and the current and longitudinal interventional impact	Data analysis completed	Intervention	2022-01-10	<NULL>	<NULL>	5140	Children with Developmental Coordinating Disorder: relationships and predictors of motor deficits and the current and longitudinal interventional impact	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8t9bqkg	<NULL>	Children from low-income families (criterion defined from the economic classification questionnaire of the Brazilian Association of Research Companies); age between 6 and 7 years; overweight or obese (defined by Body Mass Index); proper weight (defined by Body Mass Index); with motor delay.	Children under 6 and over 7 years old; children from middle and upper socioeconomic classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4ttmrg6	Children&apos;s activities and social participation	Data analysis completed	Observational	2023-12-11	<NULL>	<NULL>	6650	Activities and social participation of children with atypical Motor Development	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-22	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4ttmrg6	<NULL>	Adults with 18 years of age or older; both genders; legal guardians of children aged up to 11 years and 11 months with motor disability in Physio-therapeutic care at the School Clinic on the Realengo, campus of the Federal Institute of Education, Science and Technology of Rio de Janeiro	Guardians of children with a health condition associated with the Nervous System without motor limitations;  guardians of children with other health conditions; guardians under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-6v29sm4	Chinese auriculoacupuncture to reduce pain and impact on daily activities in elderly women treated in a specialized elderly health unit: randomized clinical trial	Recruiting	Intervention	2024-03-19	<NULL>	<NULL>	6870	Chinese auriculoacupuncture for reducing chronic pain and impact on functional capacity in elderly women treated at the elderly health reference unit (URSI): randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal de São Paulo	Unidade de Referência à Saúde do Idoso	https://ensaiosclinicos.gov.br/rg/RBR-6v29sm4	<NULL>	age from 60 years; presence of chronic osteoarticular pain for 3 months or more, and availability of time for auriculoacupuncture sessions.	presence of infection, inflammation or injury in the ear; allergy to microporous tape; carrying out prior energy therapy up to 3 months prior to the intervention; refusal to receive ear treatment. In addition, the criteria for discontinuing the intervention will be adopted: hospitalization, loss of two consecutive sessions and absence of attendance on the days scheduled for the evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-7k7w3d	Chinese herbal medicine to reduce occupational stress in nursing: Randomized clinical trial	Recruitment completed	Intervention	2019-12-27	<NULL>	<NULL>	3313	Chinese herbal medicine to reduce occupational stress in nursing: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Escola de Enfermagem da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo - FMUSP	https://ensaiosclinicos.gov.br/rg/RBR-7k7w3d	<NULL>	Women in the morning or afternoon shift; aged 20 to 50 years; classified by the Vasconcellos Stress Symptom List (LSS) with medium or high stress of 37 to 119 points and sleep fully in the dark. Will be part of the research those who voluntarily want to participate, sign the informed consent and are available for data collection.	Those with gluten intolerance will be excluded, as one of the components of the GMDZ herbal medicine is wheat. Pregnant women will also be excluded; smokers; taking glucocorticoids in the last three months; HPA-influencing drugs such as beta-blockers, glucocorticoids, antidepressants, and psychoactive drugs; employees with less than one year of work at the institution, with vacations scheduled during the research period; who are on sick leave; make use of anxiolytics and antidepressants; those who use other complementary therapy (acupuncture, herbal medicine, reiki, flower therapy, among others). Those who were already using other allopathic medicines or who were already undergoing psychological therapy will not be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8rvrb5	Chlorella supplementation produces anti-inflammatory activity and improves quality of life in pre-diabetic and diabetic patients	Data analysis completed	Intervention	2020-09-24	<NULL>	<NULL>	4288	Modulating activity of the alga Chlorella in glucose intolerant and type-2 diabetic patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Hemocentro Universidade Estadual de Campinas	Hemocentro Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8rvrb5	<NULL>	Healthy, pre-diabetic or diabetic volunteers, attended at CECOM of UNICAMP; both genders; age between 18 and 75 years; continue with their therapeutic treatment; signed informed consent form.	History of drug or alcohol abuse; diagnosis of type 1 diabetes; decompensated blood pressure; diagnoses of severe psychiatric, renal, cardiac, pulmonary, autoimmune diseases, cancer and immunodeficiencies; pregnancy and lactation; hypersensitivity to iodine; use of immunosuppressants and warfarin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-3pd52f	Chronic effect of Strengthening associated with Blood Flow Restriction on Strength, Power and Muscle Activation in healthy women: a randomized, blinded clinical trial	Not yet recruiting	Intervention	2020-09-28	<NULL>	<NULL>	4619	Chronic Effect of Resistance Exercise associated with Blood Flow Restriction on Neuromotor Performance in healthy women: clinical trial, randomized and blinded	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-30	Caio Alano de Almeida Lins	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	https://ensaiosclinicos.gov.br/rg/RBR-3pd52f	<NULL>	Women aged between 18 and 35 will be included and classified as irregularly active according to the International Physical Activity Questionnaires (IPAQ). The participant will be eligible for the study if she has a body mass index (BMI) between 18.5 and 30kg / m²; not have previous experience with training of blood flow restriction; not having diabetes mellitus or high blood pressure; not be a smoker; not using vasoactive medications or nutritional supplements regularly; not having presented an upper limb injury in the last 6 months; not having any severe rheumatic, cardiovascular or severe inflammatory or pulmonary conditions that prevent the performance of the assessments and the exercise protocol; not having any psychiatric illness or malignant tumor and not having contracted Zika or Chikungunya in the last year; not having undergone regular physical training for upper limbs in the last six months.	Participants who wish to leave the study will be excluded; have disabling health conditions that make it impossible for them to continue; use analgesic and / or anti-inflammatory resources that can interfere with any result; perform unusual or strenuous physical activities during the study period; consecutively miss sessions 29, or fail to meet at least 70% of the entire training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-686kqdx	Chronic Effect of Time Under Stress in Recreational Runners	Not yet recruiting	Intervention	2024-08-14	<NULL>	<NULL>	7219	Chronic Effect of Strength Training with Time Under Tension on the Performance of Recreational Runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-11	Universidade Federal de Sergipe - UFS	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-686kqdx	<NULL>	Volunteer for research; be 18 years of age or older; run at least three times a week with an average weekly mileage of 16 kilometers; have an average running pace of between 5 and 5:30 minutes per kilometer over a long distance; participate in a strength training program at least once a week with at least three months of practice, report no osteoarticular injuries during the last three months that compromised strength exercises and running; and have at least one year&apos;s experience in long-distance running	Individuals who do not perform all steps as instructed; present depravity in the upper respiratory tract; injuries that make it impossible to perform maximum effort during the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-563rqd9	Chronic effects of motor rehabilitation in Stroke survivors through Resistance Training and Neuromodulation	Not yet recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7887	Motor rehabilitation in Stroke survivors with severe functional impairments through Unilateral Eccentric Training combined with Cortical Neuromodulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Instituto de Física Gleb Wataghin	Instituto de Física Gleb Wataghin	https://ensaiosclinicos.gov.br/rg/RBR-563rqd9	<NULL>	Patients who suffered a stroke (type 1) more than 6 months prior to participation in the study; patients who have severe hemeparesis as a consequence of the stroke; both female and male patients; patients above 18 years old	Patients who have any type of metal inside their body (pins, pacemakers, metal prostheses, revolver bullets); patients who have any musculoskeletal injury on the affected or unaffected limbs; patients who had previous conditions such as seizures, head trauma, hearing problems, and cochlear implants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-2w7wkb	Chronic Heart Failure Remote Monitoring Application	Not yet recruiting	Intervention	2018-03-09	<NULL>	<NULL>	1682	HF in POCKET: Chronic Heart Failure Remote Monitoring Application	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Programa de Pós Graduação em Ciências Cardiovasculares	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-2w7wkb	<NULL>	Patients with a medical diagnosis of HF regardless of etiology; normal or decreased ejection fraction; older than 18 years; with functional classes I-III NYHA; participating in consultations at the specialized clinic	Patients with cognitive neurological sequelae self-reported or identified during the multidisciplinary consultation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-76b23nf	Chronic insomnia: integrative approaches with auriculotherapy and laser acupuncture to improve sleep	Not yet recruiting	Intervention	2025-12-26	<NULL>	<NULL>	8683	Integrative and complementary health practices (PICS) in the management of chronic primary insomnia: auriculotherapy and systemic laser acupuncture	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal do Maranhão	<NULL>	<NULL>	<NULL>	Age between 18 and 70 years; male and female gender; with spontaneous complaint of insomnia; agree to participate in the research by signing the Informed Consent Form; agree to provide a urine sample for biochemical and toxicological analyses; meet the clinical criteria for chronic insomnia as assessed in the anamnesis; receive diagnostic confirmation of chronic insomnia from a medical professional who is part of the research team; be available to attend all treatment sessions uninterruptedly; obtain a score equal to or greater than 5 points on the questionnaire Pittsburgh Sleep Quality Index, Brazilian version	Pregnant women; smokers; history of chronic alcohol and drug use	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-42hbfwp	Chronic Neck Pain Study using Exercises and Magnetic Stimulation	Recruiting	Intervention	2025-10-28	<NULL>	<NULL>	8466	Effects of Neuromodulation and a Therapeutic Exercise Intervention on Chronic Cervical Pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-21	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Individuals of both sexes; clinical diagnosis of chronic neck pain defined as persistent pain in the cervical region for more than 12 weeks; pain intensity equal to or greater than 3 points on the Visual Numerical Scale (VNS) at the time of screening; able to perform therapeutic exercises and repetitive peripheral magnetic stimulation (rPMS) sessions; signed Informed Consent Form approved by the Research Ethics Committee	Diagnosis of specific cervical pain of severe structural origin such as herniated disc with root compression; symptomatic spinal stenosis; vertebral fractures; cervical spine tumors; cervical surgery or invasive procedures (infiltration or nerve block) within the last six months; presence of metallic implants or pacemaker in the cervical region contraindicating the use of rPMS; degenerative neurological diseases (e.g., multiple sclerosis, severe peripheral neuropathies); active inflammatory rheumatic diseases (rheumatoid arthritis); skin hypersensitivity; cognitive impairment; other decompensated neurological and systemic pathologies; mandibular and/or palatal torus; undergoing orthodontic, speech therapy, or otorhinolaryngological treatment; continuous or prolonged use of anti-inflammatory medications due to potential interference with pain and inflammation outcomes evaluated in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:46
RBR-9bt4xv5	Chronic Spinal Cord Injury Rehabilitation with Laparoscopic Neuromodulation	Recruiting	Observational	2021-02-04	<NULL>	<NULL>	4506	Results of laparoscopic implantation of neuromodulator on patients with spinal cord injury.	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2013-12-01	Universidade Federal de São Paulo	Medtronic inc	https://ensaiosclinicos.gov.br/rg/RBR-9bt4xv5	<NULL>	Individuals aged 18 to 60 years;with partial or complete LRM from T1 to T12;with ASIA A or B score;using intermittent catheterization; with urinary incontinence;with neurological stability greater than one year	Patients with cognitive limitations;bladder atony to urodynamic study;suspected vesicoureteral reflux prior to SCI;Diabetes Mellitus, compensated or not;congenital or acquired immunodeficiencies;suspected or diagnosed malignant neoplasm;history of restosigmoidectomy, colectomy, or other surgery on the digestive system that may cause changes in intestinal transit, anal continence or evacuation function	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-2fsnrrb	Chronic®: A Study to Strengthen Muscle Health in Patients with Sarcopenia	Not yet recruiting	Intervention	2025-05-14	<NULL>	<NULL>	8004	Evaluation of the efficacy and safety of chronic® nutraceutical on muscle mass and functionality in patients with sarcopenia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-07	Universidade Federal do Amapá	Hospital Universitário da Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-2fsnrrb	<NULL>	Individuals between 65 and 80 years old; With a SARC-CalF score &gt; or = 11 points, suggestive of sarcopenia (Barbosa-Silva et al, 2016); • Minimum score on the Mini Mental State Examination &gt; 24 points; • Capacity to consent: ability to provide written informed consent; • Medication stability: participants who are on a stable medication regimen (no changes in the last 4 weeks before the start of the study), if during the follow-up they require a substantial change in the medication regimen, the participant may be excluded.	Serious medical conditions: Individuals with serious medical conditions that could interfere with safe participation in the study or interpretation of the results, such as unstable heart disease, severe renal or hepatic impairment. Supplement use: Use of other nutraceutical supplements or changes in usual supplementation in the last 4 weeks before the start of the study. Neurological diseases that affect mobility or muscle strength. Active cancer: Patients diagnosed with active cancer or undergoing treatment for cancer in the last 5 years. Recent dietary changes: Significant changes in diet in the last 3 months. Participation in other studies: Participation in other clinical studies in the last 6 months. Individuals who perform intense physical activity or strength training regularly (more than 3 times per week) in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-6vnpb2s	Chronobiological signatures and melatonin interventions in Autism Spectrum Disorder - ASD: sleep, inflammation, and sensory processing	Recruiting	Intervention	2026-03-11	<NULL>	<NULL>	8968	Changes in sleep–wake rhythm and behavior in Autism	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Individuals aged between 4 and 18 years with a neurological and/or psychiatric diagnosis of Autism Spectrum Disorder (ASD), established according to the DSM-5-TR criteria	Not using beta-blockers or other medications that affect the synthesis and release pathways of melatonin; Not using melatonin.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3h33wy	Ciprofloxacin effectiveness of the assessment to prevent bacterial infection of patients victims of accidents with snake in the Brazilian Amazon	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	791	Early empirical antibiotic therapy: a randomized clinical trial for superiority of a ciprofloxacin versus placebo in for preventing secondary bacterial infection among snakebite victims in the Brazilian Amazon	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-07-10	Universidade do Estado do Amazonas	Fundação de Amparo à Pesquisa do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3h33wy	<NULL>	To have less than 24 hours of the accident; did not to use any antibiotics before answering the institution; to have not done the antivenom for the current snakebite ; to have no abscess or infection clearly established at the time of admission ; not to be allergic to the antibiotic of choice in this study ; not to be pregnant and not accept participate.	have mental inability to understand the objectives of the study and participate in the survey; have acute or chronic unstable; unavailability of stay in hospital for seven days to follow.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-7vxcxm	Circular dance effects on quality of life in individuals whom have undergone surgery for intestinal stoma: Randomized Controlled Trial	Recruitment completed	Intervention	2016-05-16	<NULL>	<NULL>	897	Circular dance effects on quality of life in intestinal stomized patients: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-23	Universidade de Brasília - UNB	Hospital Regional de Sobradinho	https://ensaiosclinicos.gov.br/rg/RBR-7vxcxm	<NULL>	Men and women over the age of eighteen (18) years, intestinal ostomy, without participation in any dance form, showing understanding and conditions for continuing the intervention in CERPIS (Reference Center for Integrative Practices in Health), and who agree to participate in the study by signing the Informed Consent.	Children, adolescents, pregnant women, nursing mothers, bedridden, disabled and other patients deficit. Patients undergoing other alternative techniques for management of quality of life, such as meditaion, Yoga, self massage and other practices defined under the National Programme for Integrative and Complementary practices (PNPIC).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-8wytcqf	Classical Ballet Exercises together with the traditional treatment of Urinal Dysfunction to improve the child&apos;s posture: a case report	Recruitment completed	Intervention	2022-04-11	<NULL>	<NULL>	5335	Additional Classical Ballet exercise protocol to urogynecological treatment to improve body posture and voiding dysfunction in a child: a case report	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2021-10-17	Universidade Santa Cecília	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-8wytcqf	<NULL>	Being female; be 6 years old or older; enjoying dances in general; presentation of voiding dysfunction and poor postural control; have a signature of the Informed Consent Form (TCLE) signed by the parents or guardians; if a child is literate, he will be invited to sign the Assent Term	Withdrawal from participating in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-3vybj7	Classification of intensive care center patients according to the workload for Physiotherapy	Recruiting	Observational	2018-09-12	<NULL>	<NULL>	2190	Classification of intensive care unit patients according to the workload for Physiotherapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-06-22	Hospital Universitário da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3vybj7	<NULL>	Physiotherapy session of patients admitted to the adult intensive care unit of the University Hospital of University of São Paulo	Interrupted physiotherapy session; compromised data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-33rnjf	Classification of the baby who was born with low weight in Undernutrition or Preterm birth according to the response of his skin to light, a validation for the Preemie-Test	Recruiting	Intervention	2018-07-09	<NULL>	<NULL>	2803	Prematurity or Intrauterine Malnutrition? Clinical Trial for classification of the low-weight newborn through the optical properties of the skin, a validation for the Preemie-Test	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-15	Faculdade de Medicina da Universidade Federal de Minas Gerais	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-33rnjf	<NULL>	Alive newborn. Be until the first 24 hours of life. Be equal or more than 24 weeks of gestational age at birth. Birthweight less than 2500 grams. Fetal had an obstetric ultrasound assessment before 24 weeks of pregnancy or pregnant women had trustable last menstrual period. Regarding the nested control case study be newborn with diagnosing of neonatal respiratory distress syndrome or transient tachypnea assessed until 72 hours after birth. Controls will be randomly paired by ranges of gestational age.	Be malformatted with a compromise of the structure of the skin. Has anhydramnios or fetal hydrops or genodermatoses or chorioamnionitis. In the nested case-control study present extrapulmonary conditions with tachypnea not due to prematurity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-2gw2f5	Clay poultice combined with therapeutic exercises for pain reduction in patients with osteoarthritis	Data analysis completed	Intervention	2019-09-18	<NULL>	<NULL>	2962	Effect of geotherapy combined with kinesiotherapy and resistance exercise in knee osteoarthritis: single-blinded randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-03	Centro Universitário Adventista de São Paulo	Centro Universitário Adventista de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gw2f5	<NULL>	diagnosis of osteoarthritis; older than 20 years of age	presence of any other chronic disease; total or partial prosthesis in one or both knees or hips; presence of heart disease; uncontrolled hypertension; rheumatoid arthritis; fibromyalgia; neurological diseases affecting mobility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-2hyztp	Clinical alternatives for greater efficiency of home whitening. Effects of using trays with and without reservoirs	Recruiting	Intervention	2020-03-27	<NULL>	<NULL>	3675	Clinical Alternatives for greater Effectiveness of monitored Home Bleaching treatment. Effects of using trays with and without reservoirs	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-2hyztp	<NULL>	The volunteers to be included in the study must be aged between 18 and 25 years, absent caries lesions, defective and / or fractured restorations, periodontal diseases and dental elements with spontaneous pain; healthy oral soft tissues and good systemic condition; who do not have a history of adverse reaction to peroxides and anterior upper and lower teeth with a minimum A2 color	Those with restorations on the buccal surface of the central, lateral and canine incisors will be excluded; those with fixed orthodontic appliances or containing resinous residues on the vestibular surface after removal; pregnant or lactating women; smokers and those who routinely use alcohol; those who did not accept the research consent form; those who have had lightening treatment before and those with teeth that had stains due to tetracycline, fluorosis and pulping.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-10zfhxvy	Clinical analysis of Zirconia and Titanium dental implants placed in Maxilla and Mandible	Recruiting	Intervention	2023-11-20	<NULL>	<NULL>	6588	Clinical analysis of Zirconia and Titanium dental implants placed in Maxilla and Mandible. A split-mouth randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Instituto Latino Americano de Pesquisa e Ensino Odontológico	https://ensaiosclinicos.gov.br/rg/RBR-10zfhxvy	<NULL>	Need for bilateral single-tooth rehabilitation with osseointegrated implants in the maxilla or mandible; sufficient bone availability for installation of conventional-sized implants; good systemic health	Smokers and ex-smokers; diabetics; participants who are chronic users of medications (eg. Bisphosphonates, immunosuppressants, anti-inflammatories) or pathologies that alter bone metabolism (eg. Osteoporosis; Diabetes; participants who chronically use anti-inflammatories and antibiotics; bruxism sufferers; alcoholics; drug addicts; pregnant or wishing to become pregnant in the next year; history of radiotherapy treatment in the head and neck region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-9hszzh	Clinical and antimicrobial effect after use of Brazilian red propolis toothpaste	Not yet recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3439	Avaliação de dentifrício de própolis vermelha brasileira sobre redução de bactérias orais e gengivite em adolescentes em tratamento ortodôntico	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9hszzh	<NULL>	Aged between 12 and 18 years; Use of fixed orthodontic appliance; Presence of visible plaque on dental surfaces; Presence of gum bleeding Be right handed	"Present systemic changes related to the periodontal health-disease process;
They underwent antimicrobial therapy (antibiotic and / or anti-inflammatory treatment) up to six months before the research;
Licit / illicit drug users;
Are prosthesis wearers;
Carriers of less than 10 dental elements per dental arch;
Patients with a history of allergies (asthma, urticaria, rhinitis, sinusitis);"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-2n5mtq	Clinical and electromyographic follow-up of patients taking riluzole and lithium carbonate - A randomized controlled trial	Recruitment completed	Intervention	2015-07-28	<NULL>	<NULL>	565	Clinical diffusion, neurophysiological progression and prognosis of patients with Motor Neuron Disease undergoing Riluzole and Lithium Carbonate - A Randomized Controlled Trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2014-02-12	Secretaria de Estado de Saúde do Distrito Federal	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-2n5mtq	<NULL>	"Age over 18 years; no upper limit;
Disease diagnosis Motor Neuron possible, probable or definite;
Exclusion of other diseases by MRI skull and marrow and electromyography;
Forced Vital Capacity over 50%.
Size of the target sample:100"	"FVC less than 50%
other diseases exclusion"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-2pvqfdd	Clinical and functional outcomes of passive manual joint movements in intubated patients under invasive mechanical ventilation	Recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8667	Clinical and functional outcomes of Passive Joint Mobilization in patients undergoing invasive mechanical ventilation	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-02	Hospital Universitário da Universidade Federal do Maranhão	<NULL>	<NULL>	<NULL>	Patients aged eighteen years or older will be included in the study; patients of both sexes; patients on invasive mechanical ventilation for more than twenty four hours; patients presenting a sedation level between minus three and minus five according to the Richmond Agitation Sedation Scale; patients whose legal guardian agrees to participation through signing the Free and Informed Consent Form	Patients who remain under sedation with a Richmond Agitation Sedation Scale score between minus three and minus five will be excluded; patients who are unable to perform active activities will be excluded; patients who upon awakening do not agree to participate in the study will be excluded; patients whose legal guardian decides to withdraw consent will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-2c96zr3	Clinical and laboratorial evaluation of digitally fabricated dentures	Not yet recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4932	Mechanical, biological and microbiological properties of milled or printed dentures: an in vitro and clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2c96zr3	<NULL>	Regular use of the bimaxillary complete dentures for at least one year, need to replace complete dentures, good general health, absence of intraoral pathology or lesions, absence of changes in the perioral musculature	Health problems that make rehabilitative treatment unfeasible and to return appointments, severely reabsorbed ridge, palatine torus to need surgery remotion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-10n8d52v	Clinical and laboratory evaluation of Laser in the treatment of Periodontal Disease	Recruiting	Intervention	2025-09-10	<NULL>	<NULL>	8268	Clinical and microbiological evaluation of Laser Therapy in the treatment of stage III and IV Periodontal Disease patients	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-07	Universidade Federal Fluminense - Polo de Nova Friburgo	Universidade Federal Fluminense - Polo de Nova Friburgo	https://ensaiosclinicos.gov.br/rg/RBR-10n8d52v	<NULL>	Healthy volunteers; both genders; aged between 18 and 70 years; with four or more periodontal sites with probing depth greater than or equal to 6 millimeters and clinical attachment level grater then or equal to 5 millimeters non-adjacent	Hypersensitivity to the components of 0.005 percent methylene blue gel; patients who received periodontal treatment in the last six months; use of medications as anti-inflammatories and antibiotics in the last 3 months; any evidence of systemic modifying factors that may directly interfere as bias, such as: pregnant and breastfeeding women, on hormone replacement therapy, smokers, diagnosed with hyperglycemia and diabetes, osteoporosis; with HIV+ or AIDS	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-96b5zp9	Clinical and laboratory evaluation of resin materials containing bioactive particles	Not yet recruiting	Intervention	2025-01-17	<NULL>	<NULL>	7667	Clinical and in vitro performance of resin materials containing the bioactive particle S-PRG	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal do Paraná - UFPR	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-96b5zp9	<NULL>	Participants can be male or female; must be at least 18 and no more than 65 years old; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-3wyt73p	Clinical and laboratory evaluation of rewarming and bed bath of septic patients with hypothermia	Recruiting	Intervention	2020-12-11	<NULL>	<NULL>	5279	Oxyhemodynamic, biochemical, glycemic, thermographic and echocardiographic aspects of septic patients: predictive factors and impact of rewarming and bed bath	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-04	Programa de Pós-Graduação em Ciências Cardiovasculares - Universidade Federal Fluminense	Programa de Pós-Graduação em Ciências Cardiovasculares - Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-3wyt73p	<NULL>	Patients over 18 years old; admitted to the Intensive Care Unit; diagnosed with sepsis according to the criteria known as Sepsis 3; with a suspected or documented infection; with a sharp increase 2 in the SOFA index.	"Extensive burns (greater than 30% of the body surface); metastatic cancer; cerebral tumor; head trauma; spinal cord injury; pregnancy; use of active cooling less than 24 hours of sepsis diagnosis; surgery less than 24 hours after the first occurrence of hypothermia.
For thermography analyzes, patients who do not tolerate exposure to room temperature (temperature of 23 more or less 1ºC for 15 minutes) required for thermalization.
For the analysis of the impact of different types of baths on the bed, the following will also be excluded:
Individuals with continuous infusion of regular insulin at the time of bed bath, due to reduced
glycemia caused by the medication; Patients on hemodialysis (HD) when bathing in bed, due to the reduction in blood glucose caused by the procedure; Patients diagnosed with tumors that affect insulin production, due to the inability to
define whether the cause of eventual glycemic changes is the bed bath or the activity of the tumor; Patients who resent hypoglycemia (blood glucose lower than 70mg / dl) in the pre-bath moment, in addition to to control a possible confounder, avoid the occurrence of severe hypoglycemia (less than 40 mg / dL); Patients in palliative care for any pathology, because the therapeutic proposal for palliation is not consistent with curative actions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-9p22fp3	Clinical and microbiological analysis of Teeth with Aesthetic Restorations made at or below the gingival level	Recruitment completed	Observational	2024-10-31	<NULL>	<NULL>	7468	Clinical and microbiological analysis of Teeth Restored with Porcelain Veneers with supragingival and intrasulcular preparations: a cross-sectional study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-02	Centro de Pesquisa Odontológicas São Leopoldo Mandic SS	Centro de Pesquisa Odontológicas São Leopoldo Mandic SS	https://ensaiosclinicos.gov.br/rg/RBR-9p22fp3	<NULL>	Be between 18 and 40 years old; both gender; present restorative treatment with ceramic laminates in maxillary anterior teeth with at least 1 cemented ceramic laminate with margin in the supragingival region (GSup) or at least one cemented ceramic laminate with margin in the intrasulcular region up to 0.5 mm (GInt); have been rehabilitated for at least 1 year; have at least 20 teeth in the mouth; Absence of periodontitis (periodontal pocket larger than 4 mm accompanied by proximal bone loss)	Smoking patients; systemic disorders; diabetics; patients who use anti-inflammatory medication chronically 3 months before the study; use of antibiotics 3 months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-226f6j	Clinical and microbiological evaluation after treatment at the site of chronic periodontal disease, with gels containing antimicrobial agents	Not yet recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3599	Clinical outcomes and microbiological evaluation after in situ treatment of chronic periodontal disease, using antimicrobial-loaded polymeric bioadhesive systems	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-05-15	Faculdade De Odontologia de Ribeirão Preto	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-226f6j	<NULL>	Patients with chronic periodontitis, with clinical insertion level equal to or greater than 6mm in two or more teeth and probing depth equal to or greater than 5mm in one or more periodontal sites (MACHTEI et al., 1992); Age range from 30 to 75 years old; Not having used antibiotics for at least 3 months; No history of allergy to the components present in the formulations to be tested (MDZ and Tetracyclines).	Severe cardiovascular disease; Pharmacokinetic problems such as nephropathy, liver disease, etc. Patients with a history of tetracycline allergy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-9xpg3j	Clinical and microbiological evaluation of the dental canal	Recruiting	Intervention	2020-03-23	<NULL>	<NULL>	3641	Clinical, microbiological, immunological and biomolecular monitoring of different pulp and periradicular conditions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Faculdade de Odontologia de Piraicaba-Universidade Estadual de Campinas	Faculdade de Odontologia de Piraicaba-Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9xpg3j	<NULL>	Patients with systemic health condition ASA I or II. Permanent teeth with pulp necrosis; pulp vitality; pulpitis; endo-perio lesions; endodontic treatment failure; periapical lesion; periodontal tissues.	use of antifungals; antibiotics; immunosuppressants; and antivirals (up to  3 months previously to the study); and teeth with root fracture.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-69hn7t8	Clinical and patient-centered outcomes from the palatal donor area submitted to two forms of protection after free gingival graft removal	Recruiting	Intervention	2022-01-07	<NULL>	<NULL>	5137	Clinical and patient-centered outcomes from the palatal donor area submitted to two forms of protection after free gingival graft removal: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-11	Faculdade de Odontologia da Universidade Federal de Pelotas	Faculdade de Odontologia da Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-69hn7t8	<NULL>	Age 18 years and over; not having reported systemic diseases; have a healthy periodontal or demonstrate stable periodontal condition after conventional periodontal therapy; have gingival bleeding index and bacterial plaque index less than 15%; have clinical indication for periodontal plastic surgery using connective tissue graft, in order to treat single gingival recession defects, around natural teeth located in the anterior region of the mandible (canine to canine); no history of previous palatal harvest	Pregnancy or infants; report the use of medications that would adversely affect periodontal tissues; have inadequate endodontic treatment; smokers or former smokers who have stopped smoking less than a year ago; possess tooth mobility at the surgery site; possessing the need for orthodontic treatment prior to the completion of root coverage surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-9pm4r64	Clinical and population characteristics of patients with primary Antiphospholipid syndrome (APS)	Recruiting	Observational	2023-05-31	<NULL>	<NULL>	6124	Clinical and epidemiologic aspects of thrombotic primary Antiphospholipid syndrome (APS)	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-10	Faculdade de Medicina da Universidade de São Paulo	University of Turin	https://ensaiosclinicos.gov.br/rg/RBR-9pm4r64	<NULL>	Patients who meet the Sydney classification criteria for primary Antiphospholipid syndrome; age greater than 18 years old	Patients who do not have primary Antiphospholipid syndrome; patients who do not want to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-78jx54	"Clinical and radiographic comparison of bone loss around external hexagon and cone morse implants, rehabilitated
with low platform and conventional platform connections"	Recruiting	Intervention	2019-07-09	<NULL>	<NULL>	2809	Clinical and radiographic comparison of peri bone remodelingimplant in external hexagon and cone morse implants, rehabilitatedwith reduced platform and conventional platform	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-78jx54	<NULL>	"Selected individuals must be over 18 years of age and perfect
state of general health (physical and mental). To have bilateral absence of posterior teeth in
upper and / or lower arch (Kennedy Class I, 1925) and adequate bone volume; not
grafted; for the installation of at least 2 adjacent implants (Strong SW, S.I.N.
Implants, Brazil) on each side of the arcade (upper or lower). The opposing archway shall
have natural teeth and / or fixed prostheses on teeth or implants."	"Underage and / or alcohol dependent patients; drugs; medicines;
smoking; pregnant women; or who have some systemic disease; such as diabetes
controlled; coagulation disorders; allergy; heart problems or other diseases
significant; that can influence the long-term follow-up; Or the
osseointegration; be immediately deleted. Patients with partial dentures
removable; dentures and / or overdenture; shall be excluded from the sample."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-2h745w	Clinical and radiographic comparison of dental implants placed by conventional surgery and guided surgery with virtual planning	Data analysis completed	Intervention	2018-07-23	<NULL>	<NULL>	4525	Clinical and radiographic comparison of dental implants placed by conventional surgery and guided virtual surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2h745w	<NULL>	Sufficient bone structure for conventional length implants insertion, verified by CBCT; suitable mouth opening for surgical and tomographic guides, as well drill guides and drills for GVS technique; presence of both teeth adjacent to the dental element that was rehabilitated, for stabilization of the guides.	Anatomical limitation for dental implants placement or the need of bone grafting prior to implantation; patients with inflammatory alterations at the surgical site; limited prosthetic space that can preclude the restauration; pregnant or lactating women; presence of metabolic, hemorrhagic and relevant systemic disorders that could alter the tissues reparation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-35czqgf	Clinical and radiographic evaluation of implants with different thread designs and materials for 3D printing dental crowns	Recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7933	Evaluation of clinical and radiographic parameters with different macrogeometries of implants and of 3D printed resin crowns materials	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-35czqgf	<NULL>	Participants over 18 years of age; both sexes; requiring replacement with the use of two unit prostheses on implants in the posterior region of the maxilla or mandible; with healthy adjacent natural teeth (no carious lesions or any stage of periodontal disease); favorable gingival profile (thickness greater than 1.5 mm) and sufficient bone tissue to perform the implantation surgery without bone grafts or augmentations	Smokers; uncontrolled diabetes; metabolic bone disorders; history of radiotherapy to the head and neck; recent chemotherapy treatment; use of drugs that influence bone and gum tissue healing; use of illicit drugs; need for fixed partial dental prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-336mnh	Clinical and radiographic evaluation of the efficacy of pulpal revitalization treatment: randomized clinical trial	Recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3020	Clinical and radiographic evaluation of the efficacy of the application of an enamel matrix derivative (Emdogain) in regenerative endodontics: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-08	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-336mnh	<NULL>	"To be eligible in this study it will be necessary for patients to have the following characteristics:
Patient who volunteers to participate in the study, in the age group of 8 to 15 years; Possess at least one tooth with open apex and pulp necrosis with or without periapical lesion; Radiographic examination showing open apex with 2 mm diameter;
Healthy patient with absence of known allergies to the medicines used in the procedure, immune or systemic disease"	Tooth with closed apex, apical cysts and existing disease requiring long-term anti-inflammatory treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-5f8xwb	Clinical and radiographic evaluation of the survival of the implants, conditions of the tissues around the implants and conditions associated with the effectiveness of treatment in patients rehabilitated with fixed lower denture on implants	Recruiting	Intervention	2018-08-21	<NULL>	<NULL>	2135	Clinical and radiographic evaluation of the survival of the implants, conditions of peri-implant tissues and conditions associated with the effectiveness of treatment in patients rehabilitated with full-arch mandibular fixed prostheses	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5f8xwb	<NULL>	Edentulous in both arches; Both sexes; All patients should have been rehabilitated with conventional dentures at the Federal University of Rio Grande do Norte; users of new conventional dentures, with at least two (2) months of use and a maximum of one (1) year.	Presence of these conditions: diabetes, smoking, osteoporosis and immunodeficiency; have undergone radiation therapy to the head and neck; be treated with some anticoagulant therapy; younger than 18 years; torque of the implant less than 45Ncm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-5h8853	Clinical and Radiographic Evaluations of Restorations in Dentin Surface of Molars Deciduous	Data analysis completed	Intervention	2016-08-10	<NULL>	<NULL>	952	Clinical and Radiographic Evaluation of Minimally Invasive Procedures in Superficial Dentin of Primary Molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-10	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5h8853	<NULL>	4 to 9 years of age; with at least one carious lesion involving only the occlusal surfaces of primary molars upper or lower; active lesion; cavitation of at most 2 millimeters (mm) in diameter; radiographically limited if the outer half of dentin;	systemic disease; under 4 years or more than 9; inactive caries lesion; caries lesion involving other surface beyond the occlusal; lesions in the inner half of dentin;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6mwdg92	Clinical and radiological comparison of patients undergoing treatment for bone infection using standard treatment and the use of a product that replaces bone and can hold antibiotics	Recruiting	Intervention	2025-10-23	<NULL>	<NULL>	8447	Clinical and radiological comparison of patients undergoing surgical treatment of Osteomyelitis with conventional treatment and the use of synthetic graft with antibiotic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Ministerio da Saúde - Instituto Nacional de Traumatologia e Ortopedia/INTO	Hospital Estadual de Traumatologia e Ortopedia Dona Lindu	https://ensaiosclinicos.gov.br/rg/RBR-6mwdg92	<NULL>	Patients with osteomyelitis measuring up to 3 cm on radiograph; patients with soft tissue conditions for bone transport or compression-distraction surgery (traditional form of surgical treatment for osteomyelitis); presence of active fistula even with low secretion output	Presence of systemic signs of infection; lesions compatible with osteomyelitis in the metaphyseal region that make the installation of an external fixator unfeasible; tumor lesions; impossibility of standardized outpatient postoperative monitoring; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-4pt6wp	Clinical and satisfaction results from the use of one or two dental implants for removable prostheses on implants	Recruitment completed	Intervention	2020-07-08	<NULL>	<NULL>	3986	Randomized clinical study with mandibular overdentures with one or two osseointegrated implants: prospective clinical and radiographic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4pt6wp	<NULL>	"Only patients presenting the following were considered eligible for the study:
	Ability to consent to the treatment proposed; Availability to participate in the evaluations throughout the study period; Complete edentulism for at least four months, with previous use of conventional full denture; Aesthetically and functionally acceptable traditional full dentures; Appropriate psychological and physical conditions for implant surgery; A medical release for the treatment proposed (in the case of patients with controlled systemic diseases); Age of 40 years or older."	"Patients presenting the following were excluded from the study:
	Previous history of irradiation; Systemic diseases or conditions that contraindicated implant surgery; Previous treatment with oral implants; Medical/psychiatric/neurological restrictions for implant surgery; History of oral bisphosphonate treatment; Interest in other types of treatment than those proposed by the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-7sfkbgw	Clinical and side effects evaluation of a Chlorhexidine Mouthwash associated with an antimicrobial substance found in citrus fruit and Hyaluronic Acid	Terminated	Intervention	2025-10-13	<NULL>	<NULL>	8401	Clinical and side effect evaluation of Chlorhexidine mouthwash in combination with Citrox and Hyaluronic Acid	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-04-26	Rafael de Oliveira Dias	Universidade de Mogi das Cruzes	https://ensaiosclinicos.gov.br/rg/RBR-7sfkbgw	<NULL>	subjects of both genders;aged 18 to be 60 years;good general health without systemic diseases;a minimum of 20 teeth;no periodontal sites with a probing depth greater than 3 mm;and no dental caries or restorations with infiltrations	sistemic diseases;periodontal diseases and dental cavities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-9s6zpjs	Clinical aspects of  long-term follow-up of patients wtih Covid-19 after hospitalization in  HC-Unicamp	Recruitment completed	Intervention	2024-04-24	<NULL>	<NULL>	6958	Epidemiological and clinical-evolutionary aspects of a cohort of patients hospitalized with Covid-19 at HC-Unicamp	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-10	Universidade Estadual de Campinas	Hospital de Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9s6zpjs	<NULL>	Patients of both sexes; greater than or equal to 18 years old; diagnosis of severe COVID-19 who have been hospitalised; post-discharge outpatient assessment, have dyspnoea at rest; or a distance covered in the six-minute walk test of less than or equal to 400 metres and or 80% of that predicted using a predictive reference equation; or a drop in peripheral oxygen saturation of greater than or equal to 4 points	Osteoarticular or cognitive limitations; or patients with a tracheostomy; or patients with previous respiratory or cardiovascular diseases that prevent the participant from performing the proposed tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-10v96bt3	Clinical aspects related to shoulder pain	Recruitment completed	Observational	2026-04-19	<NULL>	<NULL>	9119	Understanding biopsychosocial aspects related to pain mechanism-based phenotypes of shoulder pain	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-10	Fundação de Amparo à Pesquisa do Estado de São Paulo	<NULL>	<NULL>	<NULL>	Individuals from both sexes, aged from 18 to 60 years old who report rotator cuff-related shoulder pain in the anterior, lateral or posterior region during arm movement, for more than 4 weeks and intensity of at least 3/10 on the Numerical Pain Rating Scale (NPRS) will be recruited.	Individuals with shoulder pain associated with any of the following conditions will not included: history of recurring shoulder dislocation, adhesive capsulitis (loss of 50% of passive range of motion in any direction), surgery or recent fracture (less than one year) in the upper quarter of the body, inflammatory diseases (rheumatics, infections, or related to neural, vascular or neurological causes), neurological or psychiatric diseases, history of cancer, pregnancy, cognitive deficit, physical therapy treatment or corticoid injection in the previous 6 months or any diagnose of central sensitization syndrome. Exclusion criteria will be non-attendance at the full evaluation process and incapacity to understand the questionnaires or complete all the tests.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-776sk7w	Clinical assessment of adhesive restorations in head and neck irradiated patients	Recruiting	Intervention	2024-07-17	<NULL>	<NULL>	7141	Clinical assessment of the longevity of class V adhesive restorations in head and neck irradiated patients - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-776sk7w	<NULL>	Individuals submitted to radiotherapy for head and neck cancer with the need and indication for class V restoration in at least one tooth; age 18 or above; both genders; and who agree to participate in the research by reading and signing the Informed Consent Form (ICF)	Individuals submitted to radiotherapy for head and neck cancer who have teeth in need of endodontic treatment or indirect restorations; individuals who do not wish to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-9z6hx2	Clinical Assessment of Caries Restorations in the posterior tooth with bulk-fill resin	Data analysis completed	Intervention	2018-06-06	<NULL>	<NULL>	1879	Longitudinal Clinical Assessment of Class II Cavity Restorations Using Bulk-Fill Technique: A Randomized Clinical  Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9z6hx2	<NULL>	Necessity of two Class II restorations with composite resin for decayed teeth or the necessity of changing the restoration; teeth which can be fully isolated; presence of antagonist and adjacent tooth; and teeth with vital pulp; no pain; direct pulp capping and no history of hypersensitivity	Very extensive caries lesion; pulp exposure during caries removal or cavities with a high risk of exposure; allergies to the materials to be used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8r3b7y	Clinical avaliation of patients with intestinal neuronal dysplasia after a long time period	Recruiting	Observational	2016-09-28	<NULL>	<NULL>	1177	Long term clinical follow up in patients with intestinal neuronal dysplasia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-03-06	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Julio de Mesquita Filho (FMB-UNESP)	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Julio de Mesquita Filho (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-8r3b7y	<NULL>	patients who had received histopathological diagnosis of Intestinal Neuronal Dysplasia type B; that have been diagnosed and treated for over 5 years; have agreed to participate in the study; signed informed consent term.	Refuses to participate in the study; less than 5 years after initiation of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-2xbpff	Clinical behavior of composite resin restorations silorane-based	Terminated	Intervention	2017-05-12	<NULL>	<NULL>	1230	Clinical behavior of composite resin restorations silorane-based prepared under different surface treatments: randomized controlled longitudinal study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-05	Universidade Estadual de MOntes Claros	Daniela Popoff	https://ensaiosclinicos.gov.br/rg/RBR-2xbpff	<NULL>	Patients over 18 years of age; patients had posterior teeth with indication of class I  on the occlusal face; who agreed to participate in all stages of research; patients with minimal tooth loss.	Patients not able to dental treatment because of its medical history; patients with xerostomia or were taking medication that significantly reduce salivary flow; patients with types of parafunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2tdj6vs	Clinical characteristics and outcomes of patients with Severe Acute Respiratory Syndrome during the Covid-19 pandemic.	Recruiting	Observational	2021-03-30	<NULL>	<NULL>	4591	Epidemiological study in patients with Serious Acute Respiratory Syndrome during the Covid-19 pandemic.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-03-01	Faculdade de Medicina de São José do Rio Preto - FAMERP	Hospital de Base de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-2tdj6vs	<NULL>	"Men or women; over 18 years of age with prodrome of flu-like syndrome and respiratory sign or symptom; ICU admission; need for oxygen support in a nasal catheter for up to 6 l min;
test for SARS Cov 2 virus infection after symptom onset; using a molecular diagnostic assay based on the polymerase chain reaction."	Suspected infection suggestive of fungal or bacterial etiology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-3cz6jg	Clinical characteristics of a group of smokers in a smoking cessation program	Data analysis completed	Intervention	2018-08-06	<NULL>	<NULL>	2096	Clinical and epidemiological profile of a group of smokers in a smoking cessation program	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-10	Escola Baiana de Medicina e Saúde Pública	Escola Baiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-3cz6jg	<NULL>	Smoker. Over 18 years old. Sign the term of Free consent	Carrier of serious heart disease. Carrier of mental disorders. Do not sign the Term of Free Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-6m8zhy	Clinical cohort of children with microcephaly associated with Congenital Zika Infection in Pernambuco	Recruiting	Observational	2017-12-14	<NULL>	<NULL>	1533	Clinical cohort of children with microcephaly and other abnormalities associated with congenital zika infection in Pernambuco	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-10-10	Fundação Oswaldo Cruz	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-6m8zhy	<NULL>	Pregnant women with cutaneus rash and children with microcephaly and oothers children com microcefalia and others clinical conditions related to Zika Virus	Pregnant women with rash caused by others provd  Arboviroses infection  or infection  by TORCHS group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-98rr4sm	Clinical comparison between the use of a giomer technology composite resin and resin-modified glass ionomer cement in restorations in posterior primary teeth: a randomized clinical trial	Not yet recruiting	Intervention	2024-06-17	<NULL>	<NULL>	7072	Comparison of clinical success between giomer resin composite restorations and resin-modified glass-ionomer cement in primary molars: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-10	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-98rr4sm	<NULL>	Children aging between 4 and 8 years; both genders; children presenting good health conditions; children whose parents or legal guardians accept and sign the consent form; children with at least one occlusal proximal caries in primary molars, only occlusal-proximal surfaces with caries with dentin involvement	Severe behavioral issues; presence of fistula or abscess near the selected tooth; presence of pulp exposure in the selected tooth; presence of mobility in the selected tooth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-4qn7zg	Clinical efecctiveness and tooth sensitivity of two sorts at-home bleaching treatment	Recruiting	Intervention	2019-05-07	<NULL>	<NULL>	2665	Clinical efecctiveness and tooth sensitivity of at-home bleaching treatment with 35% carbamide peroxide versus 10% carbamide peroxide- a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4qn7zg	<NULL>	Patients who have minimum age 18 years old; good general and oral health; health vital teeth. According to Vita Classical scale, the teeth must be A2 or darker. It will be necessary that pacients agre the free informed consent form (TCLE).	Volunteers who have already undergone dental bleaching, who have dental prostheses, visible enamel cracks. Pregnant or lactating; with previous dental sensitivity history; possessing dental dimming due to pathologies or use of medications; in orthodontic treatment; who are on medication that may reduce tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-4wqy488	Clinical effects of an anti-inflammatory diet in Type 2 Diabetes	Recruiting	Intervention	2026-04-06	<NULL>	<NULL>	9059	Determining the clinical effects of an anti-inflammatory microbiome restoration diet (RESTORE) in patients with Type 2 Diabetes using a strictly controlled nutritional intervention study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-10	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Non-vegetarian or vegan men and non-vegetarian/vegan women; non-pregnant and non-lactating; aged between 20 and 65; diagnosis of DM2 without target organ failure; glycated hemoglobin (HbA1c) between 6.0% and 12%; BMI &gt; 25 kg/m2	Presence of type 1 diabetes; use of insulin or more than three glucose reducing agents; history of ketoacidosis, myocardial infarction, stroke, angina or insufficiency in the last six months; diabetic retinopathy requiring treatment; kidney or liver disease; cancer requiring treatment in the last 5 years (with the exception of non-melanoma skin cancer); severe psychiatric disorder currently uncontrolled; allergy or other inflammatory and/or endocrine conditions; severe gastrointestinal symptoms; chronic use of laxative or anti-inflammatory medications; abuse of alcohol (&gt;7 drinks per week), tobacco (smoking or chewing); illicit drugs or marijuana; vigorous exercise &gt;5 hours per week; allergy or intolerance to any foods or ingredients in the dietary intervention; use of probiotics, prebiotics, fiber, omega-3 fatty acids or herbal supplements (patients will be eligible two weeks after discontinuation); use of antibiotics (patients will be eligible four weeks after discontinuation)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-25372s	Clinical Effects of Diet on Dental Bleaching	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	789	Clinical Effects of Diet Change Directive During In-office Bleaching	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-29	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-25372s	<NULL>	For the presente study, it will be selected 60 patients with the following inclusion criteria: Above 18 years-of-age; Front teeth free of caries and periodontal disease; At least one upper central incisor of A2 or darker color.	Patients who have already undergone whitening treatment; Patients with prosthesis or restorations on the labial surface of the front upper teeth; Patients with severe internal alterations of color (fluorosis and stains by tetracycline); Pregnant or lactating women; Smokers; Patients using fixed orthodontic appliances;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-366zkv	Clinical efficacy and dental sensitivity generated by hydrogen peroxide and carbamide in the office bleaching technique	Recruitment completed	Intervention	2018-07-06	<NULL>	<NULL>	1971	Clinical efficacy and dental sensitivity generated by hydrogen peroxide and carbamide in the office bleaching technique: a controlled, blinded, split-mouth clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-366zkv	<NULL>	Patients should be at least 18 years of age; good general and oral health; the 10 teeth should be present in each hemiarcate; be able to return for periodic appointments; have teeth that will be bleached free of cords; without restorations; have never been cleared before	Those who present restorations on teeth that will be bleached; have some serious pathology in the oral cavity; are pregnant or breastfeeding; have severe internal tooth discoloration; or have bruxism; a patient with chronic illness; excessive or severe calculus on the sites studied; root exposition on the teeth to be cleansed; presence of cracks in the teeth to be cleansed; users of drugs; users of alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-8dzth2	Clinical Efficacy and Gynecological Acceptance of the Product	Recruitment completed	Intervention	2018-07-19	<NULL>	<NULL>	2030	Evaluation of Clinical Efficacy and Gynecological Acceptability of Product for Health	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-10	Medcin Instituto da Pele Ltda	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8dzth2	<NULL>	66 female participants; aged 40 to 80 years; healthy with complaints of urinary incontinence and vaginal atrophy who wish to participate in the study.	Gestation or risk of gestation; use of anti-inflammatory drugs; immunosuppressants in the last 30 days or during the study; active cutaneous conditions; history of product irritation at the site of evaluation; endocrine pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7t5bhh	Clinical efficacy of a distance exercise protocol associated with telephone professional follow-up for patients with chronic knee pain	Recruiting	Intervention	2019-04-03	<NULL>	<NULL>	2584	Clinical efficacy of a distance exercise protocol associated with telerehabilitation for patients with chronic knee pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-09	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7t5bhh	<NULL>	It will be included participants aged greater than or equal to 45 years, with chronic knee pain, defined by the International Association for the Study of Pain (IASP) as recurrent pain for at least 3 months, (score 4 on the Visual Analogue Pain Scale [EVA]) and medium to moderate physical dysfunction (score&gt; 20 of 68 on the Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]).	Subjects who have undergone knee arthroplasty or other lower limb surgery will be excluded from the study, are already undergoing any treatment or exercise program, have any neurological or cardiovascular conditions that limit exercise and do not have access to a telephone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-6vbsmb	Clinical efficacy of distance exercises associated with professional telephone follow-up for patients with neck pain	Not yet recruiting	Intervention	2020-01-06	<NULL>	<NULL>	3327	Effect of a telerehabilitation exercise protocol in subjects with chronic neck pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6vbsmb	<NULL>	Participants between the ages of 18 and 65 years, neck pain for at least 3 months, with or without radiating pain, no history of significant injury to the neck or upper thoracic spine (car accident), experiencing pain during the physical exam.	Patients will be excluded if they had undergone cervical spine surgery or cervical spine stenosis, reported neurological signs, severe pain (&gt;7/10) during muscle strength measurements, rheumatic and/or inflammatory diseases (ankylosing spondylitis, rheumatoid arthreitis), cervical instability, spinal cord involvement or congenital diseases affecting the musculoskeletal system, major psychological disease (severe depression or mental disorder), pregnancy, and any intervention that included exercise or physical therapy in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-2t6zbhf	Clinical efficacy of endodontic protocols on reduction of cultivable bacteria and endotoxin in infected root canal in patients who have undergone radiation therapy to the head and neck	Terminated	Intervention	2021-09-08	<NULL>	<NULL>	4864	Investigation of endodontic microbial condition in irratiated patients with cancer.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	universidade estadual paulista	universidade estadual paulista	https://ensaiosclinicos.gov.br/rg/RBR-2t6zbhf	<NULL>	Patients who have undergone radiation therapy of at least 50 Gy for malign tumor in the head and neck needing primary endodontic treatment were included in this clinical research. Only single-rooted teeth with diagnostic of primary endodontic infection that was confirmed by a negative response to cold thermal testing with difluorodichloromethane at -50°C (EndoFrost; Roeko, Langenau, Germany) were selected.	The time from the last radiation session had to be a minimum of 6 months. A further requirement was the non existence of periodontal pockets deeper than 4 mm. Teeth not able to be isolated with rubber dam were excluded. Patients under antibiotic treatment in the last 3 months could not be included in this clinical study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-5vtrng9	Clinical efficacy of Viscoflex® Viscosupplements	Terminated	Intervention	2024-01-10	<NULL>	<NULL>	7779	Single-blind study of clinical efficacy, perceived efficacy, and tolerability of Viscoflex®	<NULL>	1, single-arm-study, single-blind	1	<NULL>	<NULL>	<NULL>	2023-10-15	Vênus Medicina Física e Reabilitação S/C Ltda	Vênus Medicina Física e Reabilitação S/C Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5vtrng9	<NULL>	Age group from 40 to 59 years old (during the pandemic and not belonging to the risk group – see exclusion criteria); male and female genders; Fitzpatrick skin type: I to V; participants with osteoarthritis (knee, shoulder, trapezius regions, and metacarpal);intact skin in the test area	Skin disorders in the region of product application (joints);pregnant or breastfeeding women;history of hypersensitivity to hyaluronic acid;Immunodeficiency;tendency to form hypertrophic or keloid scars;continuous use of anticoagulants or acetyl salicylic acid;use of surfactants containing quaternary ammonium salts in dermatological preparations;venous or lymphatic stasis in the limb to be treated;signs of inflammation and/or infection in the joint to be treated;persons in any of the COVID-19 risk groups, that is, over 60, with diabetes, chronic cardiovascular, kidney or respiratory disorders, immunosuppressed or bearing any other conditions that the medical doctor deems as belonging to a risk group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-7g5zng	Clinical efficiency of two sequences of orthodontic wires to correct crowding of the lower anterior teeth	Terminated	Intervention	2015-03-17	<NULL>	<NULL>	423	Comparison of the clinical efficiency between two wires sequences for orthodontic alignment and leveling	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-10	Centro Universitário do Maranhão	Centro Universitário do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-7g5zng	<NULL>	Moderate mandibular anterior crowding (3-6 mm); all teeth present in the mandibular arch, up to second molars; no prescription for extractions in the mandibular arch; no need for treatment with intermaxillary elastics, interproximal stripping, open NiTi compression springs or active labial bow; no diseases that might affect tooth movement; and significant tooth size and shape abnormalities.	Patients with a history of trauma; resorption and that, for any reason, did not visit the clinic for more than a month; whose mandibular appliance broke; who had undergone previous orthodontic treatment .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-77sbfp	Clinical evaluation and digital monitoring of patients submitted to Home Dental Bleaching	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1752	Randomized clinical evaluation and digital Monitoring of patients submitted to Home Dental Bleaching: Effect of wear-time of dental bleaching on the degrees of Collaboration and patient Catisfaction, on the Effectiveness and occurrence of Sensitivity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-31	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-77sbfp	<NULL>	Absence of caries injury; Absence of defective or fractured restorations; Absence of periodontal diseases; Good systemic condition; Healthy oral soft tissues; No historical adverse reaction station to peroxides; teeth with a minimum of A2; Absence of dental elements with spontaneous pain; Absence of non-carious cervical lesions and of dentinal tissue exposed in the incisal regions.	Restorations in the vestibular of the central, lateral and canine incisors; Teeth with orthodontic appliances fixed or containing resinous residues after their removal; Pregnant or breastfeeding; Smokers and Patients who routinely use alcohol; Have previously had bleaching treatment; Teeth with fluorosis enamel stains and without pulp;  Patients with bruxism habits and those who experienced dental sensitivity prior to the experiment; Did not accept the search consent form; Unavailability of time and commitment to research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-7kjzrk	Clinical Evaluation and Temperature Variation between Gum Removal with Scalpel and Laser	Recruitment completed	Intervention	2020-05-29	<NULL>	<NULL>	3889	Clinical and Thermographic Evaluation of Conventional and High-Power Laser Gingivectomy - Split Mouth Controlled Clinical Trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7kjzrk	<NULL>	Patients with gummy smile. Clinically healthy periodontum. Absence of systemic diseases. Age between 18 and 49 years.	Smokers. Presence of orthodontic appliance. Use of medications that interfere with bleeding, pain perception and promote gingival enlargement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-389mzn	Clinical evaluation and treatment of voice tremor with botulinum toxin and propranolol.	recruiting	Intervention	2012-01-31	<NULL>	<NULL>	68	Clinical evaluation and treatment of voice tremor with botulinum toxin and propranolol.	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Federal de São Paulo	Capes	https://ensaiosclinicos.gov.br/rg/RBR-389mzn	<NULL>	presence of vocal tremor to perceptual analysis and larynx; older than 18 years, both sexes	presence of laryngeal spasm during laryngoscopy or auditory perceptual, presence of lesions on laryngoscopy, patients with previous treatment, contraindication to propranolol or botulinum toxin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-7ybwkm	Clinical evaluation in humans of alveolar bone preservation after filling by bovine composite bone substitute	Data analysis completed	Intervention	2018-03-02	<NULL>	<NULL>	1674	Evaluation of the maintenance of alveolar bone volume in humans, after filling with bone composite of bovine origin, clinical evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Faculdade de Odontologia de Araçatuba - UNESP	Centro de Pesquisas São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-7ybwkm	<NULL>	Healthy patients, surgical risk ASA I; requiring extraction of a single uniradicualar tooth for posterior placement of osseointegrated implant; without periapical lesion; or periodontal disease; and preserved alveolus with 5 wall after the surgical procedure of tooth extraction.	Patients with incompatible age established by the study; patients with systemic diseases; smoking patients; patients with periodontal disease or periapical lesion; and patients who after the exodontia procedure did not present the alveolus preserved with 5 walls.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-2n2g2p5	Clinical evaluation of a chemical active composite in atraumatic restorative treatment in primary teeth: randomized, double-blind clinical trial	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7534	Clinical evaluation of a self-polymerizing composite in atraumatic restorative treatment in primary teeth: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2n2g2p5	<NULL>	Patients with one class II cavities  in deciduous molars; healthy and cooperative patients; patients between 4 and 8 years old; be male or female	Patients with systemic diseases; patients with erosion, bruxism and incisal wear; use of orthodontic appliances; allergy to the materials used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-65zy7x	Clinical evaluation of a dental adhesive containing copper nanoparticles in composite resin restorations in dental lesions near the gingiva	Recruitment completed	Intervention	2017-09-19	<NULL>	<NULL>	1387	Clinical evaluation of a universal adhesive system containing copper nanoparticles in composite resin restorations in non-carious cervical lesions: triple blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-20	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-65zy7x	<NULL>	Patients older than 18 years will be included; Presence of at least two LCNC per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-5fhmpq	Clinical evaluation of a dental adhesive containing zinc and copper nanoparticles in composite resin restorations in dental lesions near the gingiva	Not yet recruiting	Intervention	2019-02-11	<NULL>	<NULL>	2473	Clinical Evaluation of an Universal Adhesive System containing Zinc and Copper Nanoparticles on Composite Restorations in Non-Carious Cervical Lesions: a Double-Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5fhmpq	<NULL>	Patients older than 18 years will be included; Presence of at least two LCNC per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-998r5b	Clinical evaluation of a fluid material to cover tooth cavities with lesions close to the gum.	Recruitment completed	Intervention	2020-03-24	<NULL>	<NULL>	3652	Clinical evaluation of Methacrylate and Ormocer® fluid composite resins in noncarious cervical lesions.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-998r5b	<NULL>	Patients over 18 years old will be included; presence of at least two non-carious cervical lesions per patient regardless of their location in the dental arch; need of restorative treatment; adequate oral hygiene; absence of motor difficulties that prevent the performance of adequate oral hygiene; absence of periodontal disease active caries lesions and parafunctional habits; at least 20 teeth in function; absence of active removable partial denture clips on the teeth included in the research and that these are not prosthetic pillars; non-carious cervical lesions with a maximum of 50% enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-8txr4fw	Clinical evaluation of a monochromatic composite resin of dental restoration	Recruiting	Intervention	2022-05-26	<NULL>	<NULL>	5407	Clinical evaluation of a monochromatic composite resin	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8txr4fw	<NULL>	Good general health; good oral hygiene; have at least 20 teeth under occlusion. At least two comparable non-carious cervical lesion (in size; shape and dimensions); non-retentive; deeper than 0.5 mm; and involving both enamel and dentin of vital teeth. The cavo-superficial margin cannot involve more than 50% of the enamel	Extremely poor oral hygiene; using orthodontic devices; severe or chronic periodontitis; heavy bruxism habits. Known allergy to resin-based materials or any other material used in this study. Pregnant or lactating women; chronic use of anti-inflammatory; analgesic and psychotropic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-5hs9prz	Clinical evaluation of a Monochromatic Flow Composite Resin of dental restoration	Recruiting	Intervention	2023-10-24	<NULL>	<NULL>	6532	Clinical performance of a Flow Composite Resin with intelligent chromatic technology for restoration of Non-Carious Cervical Lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5hs9prz	<NULL>	Good general health;good oral hygiene;present at least 20 teeth under occlusion;at least two non-carious cervical lesions comparable in size;format and dimensions;non-retentive;deeper than half a mm;and involve both the enamel and dentin of vital teeth;The cavo-superficial margin cannot involve more than 50% of the enamel	Extremely poor oral hygiene;using orthodontic devices;severe or chronic periodontitis;heavy bruxism habits;known allergy to resin-based materials or any other material used in this study;pregnant or lactating women;chronic use of anti-inflammatory;analgesic and psychotropic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-8pzmt86	Clinical evaluation of a nystatin-containing gel for the treatment of denture-associated candidiasis	Recruiting	Intervention	2026-02-13	<NULL>	<NULL>	8876	Mucoadhesive containing nystatin complexed with β-cyclodextrin for the treatmente of Denture Stomatitis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-04	Faculdade de Odontologia de Bauru - Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Individuals who are users of conventional removable maxillary complete dentures; with a clinical diagnosis of denture stomatitis on the palatal mucosa supporting the denture; of both sexes, without age restrictiont; who present a positive smear for Candida on the palatal mucosa and/or on the internal surface of the maxillary complete denture; who agree to participate in the study and sign the Informed Consent Form	Individuals with anemia or uncontrolled endocrine disorders; undergoing antineoplastic treatment with radiotherapy and/or chemotherapy; who have used antibiotics, steroids, or antifungal agents within the last three months; users of the same maxillary complete denture for a period longer than 30 years	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-4wrk7dy	Clinical evaluation of a universal material to cover tooth wear close to the gum before and after in-office whitening	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7716	Universal composite resin color compatibility before and after in-office whitening	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4wrk7dy	<NULL>	Minimum age of 18 years; both genders; good oral hygiene; present at least 20 teeth under occlusion; at least two non-carious cervical lesions comparable in size, shape and dimensions; non-retentive; deeper than half a millimeter; involve both the enamel and dentin of vital teeth; the cavosurface margin cannot involve more than 50% of the enamel	Extremely poor oral hygiene; wearing orthodontic appliances; severe or chronic periodontitis; heavy bruxism habits; known allergy to resin-based materials or any other material used in this study; pregnant or lactating women; chronic use of anti-inflammatory drugs; analgesics and psychotropic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-4rw55d	Clinical Evaluation of Adhesives for Restoration of cavities in the Cervix of the Teeth not Caused by Caries	Data analysis completed	Intervention	2018-04-27	<NULL>	<NULL>	1733	Randomized Clinical Evaluation of Simplified Adhesive Systems in Non-Carious Cervical Lesions: Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-10	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4rw55d	<NULL>	"Being in good general health; Be over 18 years of age; Have an acceptable level of oral hygiene; To present at least 20 teeth under occlusion; To have at least 4 non-carious lesions on different teeth to be restored.
The lesions should be non-carious, non-retentive, with a depth greater than 1mm, and enamel and dentin envelopment of vital teeth without mobility; The cavo-superficial margin can not involve 50% more enamel."	Patients with extremely poor oral hygiene; Cronic or severe periodontitis; Severe parafunctional habits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-2w3p7z7	Clinical evaluation of an adhesive containing stabilizate silane in non-carious lesions	Recruitment completed	Intervention	2025-08-13	<NULL>	<NULL>	8206	Clinical Evaluation of an Universal Adhesive containing Stabilizate Silane in Non-Carious Cervical Lesions: Randomized Clinical Trial, triple-blind.	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2025-04-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2w3p7z7	<NULL>	The inclusion criteria considered patients classified as ASA I or II, aged between 18 and 65 years, who presented good oral hygiene and at least 20 teeth in occlusion. Furthermore, participants should present at least two non-carious cervical lesions (NCCLs) with a depth greater than 1mm.	The exclusion criteria are: individuals with periodontal disease, characterized by probing depth greater than 3 mm, gingival bleeding, or dental mobility of grade II or higher. Also excluded were individuals with parafunctional habits, smokers, orthodontic appliance wearers, teeth serving as prosthetic abutments, and pregnant women. Finally, individuals who did not agree with the research terms or who presented difficulties in attending the necessary follow-ups after the restorations were performed were also excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-2f9w4yy	Clinical evaluation of an experimental product based on Essential Oils for brushing Complete Dentures	Recruiting	Intervention	2024-03-20	<NULL>	<NULL>	6876	Evaluation of experimental Dentifrices based on Essential Oils for Complete Dentures cleaning - Randomized, controlled and crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-14	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2f9w4yy	<NULL>	Inclusion criteria will be 25 patients from both sex; Good general health; Previous and regular use of bimaxillary complete denture made of thermopolymerizable acrylic resin for at least one year and in adequate conditions; Upper complete dentures must also present biofilm on the internal surface and quantification will be carried out according to the Additive Index	Cognitive impairment; Motor difficulties; Prostheses with adaptation problems, relining, repairs or fractures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-548n3sx	Clinical evaluation of antibiotic use in dental implant surgery	Recruiting	Intervention	2021-02-12	<NULL>	<NULL>	4545	Prospective analysis of the use of antibiotics in surgery for the installation of osseointegrated dental implants	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Hospital Universitário Onofre Lopes	Departamento de Odontologia-Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-548n3sx	<NULL>	Need for dental implants for rehabilitation; surgery for installing two-stage dental implants; up to 5 implants in the same surgical procedure; those who agreed to participate after explaining the research, by signing the informed consent form	"Risk of bacterial endocarditis; any systemic or local immunodeficiency; uncontrolled diabetes mellitus; previous radiation therapy in the head and neck area; need for a bone augmentation procedure (grafts) concomitant with implant installation;  1-stage implant surgery; immediate implants and in cases of immediate loading
• Allergy to penicillin, dexamethasone or sodium dipyrone;
• Presence of chronic or acute infection in the vicinity of the planned implant site;
• Already on antibiotic and anti-inflammatory treatment for any other reason;
• Treated or being treated with intravenous or oral antiresorptive medications (bisphosphonates and denosumab);
• Pregnant or infant;
• Enrolled in other clinical studies whose interventions could interfere with this research;
• Under 18 years of age or unable to sign the consent form."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-75kq9s2	Clinical evaluation of bleaching efficacy, sensitivity, and oxygen level of the dental pulp when tooth bleaching with titanium dioxide nanoparticles associated with fluorine and nitrogen	Recruiting	Intervention	2023-09-19	<NULL>	<NULL>	6449	Clinical evaluation of bleaching efficacy, sensitivity, and pulp saturation level of bleaching treatments with titanium dioxide nanoparticles co-doped with fluorine and nitrogen	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-75kq9s2	<NULL>	Provide written and signed consent; Complete the vaccination schedule for COVID-19; Agree NOT to participate in another clinical trial during the course of the project; Present good general and oral health; Have not undergone dental bleaching in the last 3 years or have undergone it in the last 3 years, but have teeth darker than color A2; Having vital teeth in question (Positive response to the cold sensitivity test, absence of signs or symptoms of pulpal or periapical pathology, absence of radiographic signs of periapical pathology); No edentulous space between the premolars of each arch (upper and lower); Upper incisors must be classified as A2 or darker in color and free of caries and/or restoration; Age (over 18 and under 30); Being in treatment or other activities in FOP, not generating the need for exclusive visits for the research	Participating in another clinical trial; Presenting with a pre-existing medical condition (pregnant, lactating, smoking, or routine use of alcohol) or oral condition (non-vital teeth, dental caries in the region where the bleaching will be performed, need for endodontics, orthodontics or periodontal treatment and poor oral hygiene) that the investigator/examiner deems could put the individual at risk during the study; Have an adverse reaction to the materials used or a medical or dental history that could interfere with the progress of the study; Unable to attend appointments; The teeth in question have cracks or other defects that may increase the risk of pulpal toxicity; Is under treatment or needs periodontal treatment or caries; Have teeth lighter than color A2; Have extensive restorations on the teeth that will receive bleaching; Patient has a history of tooth sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-9d2ycv	Clinical evaluation of carious dentin in caries lesions in posterior teeth before and after caries removal and the relation with the clinical success of the restoration	Recruitment completed	Intervention	2018-08-02	<NULL>	<NULL>	2084	Clinical evaluation of  carious dentin in out  in primary molars before and after excavation and the relationship with the clinical success of restoration	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9d2ycv	<NULL>	Primary teeth occlusal caries in children between three to six years old	Pain history, abcess and periapical lesion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-4493ct	Clinical Evaluation of Ceramic Restorations Glued to the Tooth	Not yet recruiting	Intervention	2019-03-21	<NULL>	<NULL>	2535	Clinical Evaluation of Ceramic Facets Luting with Ceramic Self-Etch Primer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4493ct	<NULL>	Patients older than 18 years, patients with indication for dental contact lenses or ceramic facets, at least from canine to canine, who accept the terms of the research.	Patients smokers, pregnant or lactating, patients with high risk of caries and / or periodontal disease, or patients with some systemic deficiency that prevents periodic monitoring.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-8fgft5	Clinical evaluation of ceramic veneers manufactured by computed technology	Recruiting	Intervention	2016-05-22	<NULL>	<NULL>	858	Clinical evaluation of lithium disilicate veneers manufactured by cad/cam technology	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-30	Universidade de São Paulo, Faculdade de Odontologia de Bauru	Fundação de Amparo à Pesquisa do estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-8fgft5	<NULL>	"Patients over 18 years;
Accordance with the TCLE;
Patients who have an indication for veneers: discoloration, tooth wear, fracture or anterior teeth with malformation;
Patients who have good general health during clinical evaluation period, good value mandibular and maxillary occlusal stability;
Patients who have need of treatment by at least two teeth and at most six teeth(region between canines)."	"History of allergy to any of the materials to be used in research
Drugs that could interfere with the oral environment;
Systemic or malignant diseases at the beginning of the study;
Inability to be subjected to specific techniques for performing the experiment not enough space for proper preparation of veneers;
Patients with parafunctional habits;
Patients with periodontitis severe gum inflammation;
Inadequate oral hygiene or high caries rates."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2nz5s2	Clinical evaluation of coca cola soda exposure after tooth whitening of vital teeth	Recruitment completed	Intervention	2017-05-03	<NULL>	<NULL>	1221	Clinical evaluation of exposure to glue derivatives after tooth whitening of vital teeth	<NULL>	1-2, non-randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2017-01-25	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-2nz5s2	<NULL>	patients aged between 18 and 50; to sign the consent form; good oral health in general; the presence of all the upper and lower front teeth (first premolars, canines and incisors) with vitality; injury-free caries and unsatisfactory restorations; no cervical lesions (abrasion, erosion and abfraction); absence of periodontal disease; non-smoking; initial color of the teeth be A2 or darker	patients undergoing any prior bleaching procedure; pregnant or breastfeeding women; teeth showing staining caused by tetracycline; fluorosis; hyperplasia; endodontic treatment, restorations or prostheses on some of the six upper and lower anterior teeth; receding gums; tooth sensitivity; submit parafunctions;  were on medication that contained heavy metals; analgesics; anti-inflammatory	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-286pv6k	Clinical evaluation of color compatibility between monochromatic composite resin and the tooth after dental whitening	Not yet recruiting	Intervention	2024-10-23	<NULL>	<NULL>	7455	Evaluation of color compatibility of monochromatic composite resin with the tooth after in-office bleaching - randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-286pv6k	<NULL>	Age between 18 and 60 years; in good general and oral health; presenting healthy upper canines with color variation A3 to D4 on the Vita scale; no pain or pulp alteration in the tooth to be whitened; consent to participate in the research; both sexes	Use of fixed orthodontic appliances; active periodontal disease; endodontic treatment on the upper anterior teeth; pregnant patients; smokers; presence of cavities or restoration in the tooth to be whitened	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-6fsy6z	Clinical Evaluation of Composite Resin Restaurations Posterior Teeth	Recruitment completed	Intervention	2018-03-05	<NULL>	<NULL>	1675	Clinical Behavior of Composite Resin Restauarations of Oclusal Cavities in Posterior Teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-04	Universidade Federal de Pernambuco	Uninovafapi	https://ensaiosclinicos.gov.br/rg/RBR-6fsy6z	<NULL>	Patients should be 17 years of age or older, have a need for restorative treatment on occlusal surfaces of at least four posterior teeth, and dental elements that antagonize restorations should be healthy or satisfactorily restored.	Patients with dental elements antagonistic to non-healthy restorations were excluded; not satisfactorily restored; restored with ceramic material and missing or removable / movable prosthetic parts holders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-8n5n3v	Clinical Evaluation of Composite Resin Restoration After Removal of Caries Lesions Using Laser	Recruitment completed	Intervention	2019-01-23	<NULL>	<NULL>	2456	Longitudinal Clinical Evaluation of resin composite restoration after Selective Caries Removal using an Er:Yag Laser	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8n5n3v	<NULL>	Inclusion criteria were: four active dentin caries lesions; permanent molars with pulp vitality; permanent molars with absence of sealants; absence of amalgam restorations; absence of glass ionomer cement; absence of composite resin restorations.	First molars without pulp vitality; presence of sealants; presence of amalgam restorations; presence of glass ionomer cement; presence of composite resin restorations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-4cfz6sp	Clinical Evaluation of Composite Resins Tetric N-PowerFill 2 vs. Tetric NCeram 2 in Deciduous Molars: A Clinical Study	Not yet recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7708	Clinical Evaluation of Tetric N-PowerFill 2 vs. Tetric N-Ceram 2 in primary posterior teeth: A prospective, randomized, double-blinded parallel study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4cfz6sp	<NULL>	Good general and oral health; no need for endodontic or periodontal treatment; patients between three and ten years old who require a restoration in a primary posterior tooth; any gender	Severe systemic diseases; poor oral hygiene; allergy to any components present in the materials used; patients with a high risk of pulp exposure; endodontic complications; chronic use of medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-69p7mpr	Clinical evaluation of dental adhesives applied in different techniques in non-carious cervical lesions	Recruiting	Intervention	2022-06-09	<NULL>	<NULL>	5423	Clinical Evaluation of Clearfil S3 Bond Universal Quick applied in different techniques in non-carious cervical lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Andres Felipe felipe Millan Cardenas	Centro Universitário de Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-69p7mpr	<NULL>	Age between 18-50 years old; Participants must have at least three comparable LCNCs (in size, shape, and dimensions) to be restored; These lesions must be non-retentive, deeper than 1 mm, and involve both enamel and dentin of vital teeth without periodontal disease; Acceptable oral hygiene and have at least 20 teeth under occlusion.	The cavo-superficial margin cannot involve more than 50% of the enamel; Extremely poor oral hygiene or using orthodontic treatment; Severe or chronic periodontitis or heavy bruxism habits; Known allergy to resin-based materials or any other material used in this study; Pregnant or lactating women; Patients with chronic use of anti-inflammatory, analgesic and psychotropic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-5t6bd9	Clinical evaluation of dental bleaching with violet LED	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1826	In vivo analysis of Violet Led associated or not with peroxides on the efficacy and safety of dental bleaching	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-30	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5t6bd9	<NULL>	"Sign Informed Consent Form; agree to not participate of any other clinical trial during this study; present good general and oral condition;
have not been undergoone dental bleaching over the last 3 years or to present shade higher than A2 (vita SCALE); teeth submitted to dental bleaching with vitality; not present any edentulous space between premolars in both arches; upper right central incisor and canine must present shade higher than A2; the participant must be over 18 and under 60 years old."	Be participating of another clinical trial; not agree to afford for the displacement until the Dental School; present dental caries or gengivitis after clinical examination; present any allergy to one of the materials used in the clinical procedures for bleaching and mineral content analysis; not be able to attend all the appoitments necessary until the end of the treatment; patients with cracks on the teeth that will receive bleaching, once this could enhance tooth sensitivity; present upper right central incisor and canine brighter than A2; present wide restorations on the teeth that will be bleached.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8gcd45	Clinical Evaluation of Dental Restorations in Composite Resin made 14 years ago	Data analysis completed	Observational	2018-02-07	<NULL>	<NULL>	1637	Clinical Evaluation of Restorations in Composite Resin Packable and micro-hybrids performed 14 years ago	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-10	Faculdade de Odontologia da Universidade Federal de Pernambuco	Faculdade de Odontologia da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8gcd45	<NULL>	Patients with indication of restoration in at least 3 posterior teeth; good oral hygiene condition; healthy or properly restored antagonistic teeth.	Have made any changes in the restorations, replacements, repairs, prostheses; loss of dental elements analyzed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-6th7rt	Clinical evaluation of different delivery methods of At-home bleaching with 10% Hydrogen Peroxide	Data analysis completed	Intervention	2017-07-26	<NULL>	<NULL>	1310	Sensitivity and Genotoxicity assessment in adolescents submitted to Bleaching with Strips or Trays	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	UFAM - Universidade Federal do Amazonas	UFAM - Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-6th7rt	<NULL>	Volunteers had between 15 and 20 years; at least one central incisor or canine with A2 or darker color; six upper anterior teeth restorations-free on the buccal surface.	Volunteers with systemic diseases (metabolic, immunological and cardiopathies); periodontal disease; enamel showing changes; volunteers with braces; severe crowding; presence of intrinsic stains; use of anti-inflammatory drugs; smoking; drinking; in pregnancy or lactation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-9qdnws	Clinical evaluation of drugs in people with dry mouth	Data analysis completed	Intervention	2018-08-01	<NULL>	<NULL>	2080	clinical evaluation of Pilocarpine release systems in individuals with hyposalivation	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-04-04	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9qdnws	<NULL>	"Volunteers aged 18 or over.
With clinical diagnosis of hyposalivation salivary flow at rest less than or equal to 0.1 ml / min for at least two weeks before the research with no probability of resolution during the experimental period. There is no known allergy or sensitivity to pilocarpine.Ability to give informed consent in writing and meet all testing requirements."	No possibility of changing any drug with the potential to cause xerostomia within the research period. No intervention such as: radiotherapy, chemotherapy, surgery that could change the symptoms of xerostomia in the two weeks prior to the survey or during the study period. Eye problems contraindicate the use of parasympathetic agents (eg iridocyclitis, increased intraocular pressure). Other conditions, where there is a risk of worsening of medical problems during the evaluation period (eg severe or uncontrolled asthma or pulmonary disease, hypo or hypertension (uncontrolled), hyperthyroidism, uncontrolled seizures or cardiac arrhythmias, HIV and Hepatitis C). Established oral infections (eg, candidiasis, herpes infections, mucositis, canker sores).Pregnant women and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-10cg75rw	Clinical evaluation of in-office Bleaching Agents	Recruitment completed	Intervention	2024-03-25	<NULL>	<NULL>	6891	Evaluation of different In-office Bleaching Agents: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10cg75rw	<NULL>	Have at least 24 teeth in the mouth. Be interested and available for treatment. Good periodontal health, without the need for interventions. Good general health. Dental elements color A3 or darker according to the Vita Classical shade guide. Caries-free teeth.Teeth without restorative needs	Patients who refuse to participate in the treatment. Pregnant women. Nursing mothers. Smokers. Patients with bruxism or another condition that causes gingival recession and/or dentine exposure. Patients who have already undergone dental bleaching. Patients who report spontaneous sensitivity and/or sensitivity generated by cold drinks and foods. Patients undergoing orthodontic treatment. Patients undergoing periodontal treatment. Patients with ISG &gt;30% of the areas/sites involved. Patients with IPV &gt;30% of the areas/sites involved. Anterior teeth with restoration on the buccal surface. Anterior teeth with veneers or crowns.Teeth with internal staining (tetracycline, fluorosis or endodontic treatment). Endodontically treated anterior teeth.· Patients being treated with anti-inflammatories and/or analgésico	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-6rkfp2	Clinical evaluation of Ion z glass ionomer cement restorations in children	Recruitment completed	Intervention	2019-12-12	<NULL>	<NULL>	3275	Efficacy of Ion Z glass cement in microbin control in carie inclusive interior dentina	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-09	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6rkfp2	<NULL>	"Children who are 4 to 7 years old;
IC signed by the parent or guardian of the child;
TA filled in by the children;
Present at least 1 deciduous molar with carious lesion on the occlusal surface, with radiographic depth in the inner half of dentin;"	"The exclusion criteria:
Children who exhibit inappropriate behavior during dental care;
Decayed teeth with clinical and radiographic signs of pulp involvement."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-7qnprq	Clinical evaluation of new local anesthetics for oral application	Data analysis completed	Intervention	2020-01-30	<NULL>	<NULL>	3431	Efficacy and pharmacokinetics of new topical local anesthetic formulations for the oral mucosa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7qnprq	<NULL>	Age 20 to 45 years; Healthy; Students form graduation or post graduation from Universidade São Francisco or Universidade Estadual de Campinas; only the subjects having the upper right canine free of caries, large restorations, periodontal disease, past endodontic treatment, oral mucosal with no trauma or sensitivity were included.	Allergy to local anesthetic; cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal and hematological diseases, psychiatric disorders; use of any medication, except oral contraceptives one  week prior or during the experiment; smokers; addictive behavior with drugs or alcohol; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-6w5gwh	Clinical evaluation of non-carious cervical lesions of different sizes, restored with two resin composite	Recruitment completed	Intervention	2017-08-15	<NULL>	<NULL>	1332	Longitudinal clinical evaluation of non-carious cervical lesions of different sizes, restored with bulk-fill or conventional resin composite: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-08	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6w5gwh	<NULL>	At least 18yrs old; good health; do not have active caries or periodontal disease; to have non carious cervical lesions, in canines and premolars, at least 1 mm depth; to have at least 1 lesion; to have antagonist and adjacent teeth; teeth must to present vital pulp; no parafunctional habits.	Medical condition that may interfere with the safety of the volunteer during the study period, or allergic reactions to the substances and / or products will be used; use of removable prostheses which have the clamps resting on the teeth used for the research; parafunctional habits; smoking patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-6685wt	Clinical evaluation of Ozone gas efficiency on Tooth sensitivity and Tooth whitening	Recruiting	Intervention	2019-12-09	<NULL>	<NULL>	3259	Clinical evaluation of the toxicity and efficiency of Dental Bleaching associated with Ozone gas	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade Estadual do Oeste do Paraná - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-6685wt	<NULL>	The third molars must be sound; and with initial color of teeth A2 or more saturated.	Pregnant and lactating patients; patients who had teeth with severe internal discoloration (resulting from tetracycline stains, fluorosis or endodontic treatment); patients with teeth under potential conditions for sensitivity, such as gingival recession, dentin exposure and poor enamel formation; patients who reported sensitivity already existing at the time of the anamnesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-934sys	Clinical evaluation of pain during gum treatment using anesthetic gels with no needles.	Recruitment completed	Intervention	2017-03-23	<NULL>	<NULL>	1189	Clinical evaluation of pain perception during scaling and root planning, using non-invasive lidocaine/prilocaine thermosetting liposomal anesthesia gel.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-09-01	Universidade Estadual de Ponta Grossa	Curso de Odontologia - Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-934sys	<NULL>	Healthy volunteers, any gender, older than 18 years, at least three sextants who require periodontal treatment, at least one tooth with clinical depth of probing &gt;= 4mm.	Volunteers under periodontal maintenance, sensitivity or allergy to amide-based anesthetics, use of analgesic or anesthetic medication at least 12 hours prior to the procedure, previous history of alcoholism, pregnant or lactating women, uncontrolled severe systemic disease, acute local pathological alterations, dental extraction needs, dentin hypersensitivity and endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-7twgjp6	Clinical evaluation of polymp active zinc to decrease dentinal hipersensibility	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6397	Clinical evaluation of polymp active (Zn) to decrease dentinal hipersensibility	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Andres Felipe felipe Millan Cardenas	Centro Universitário de Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-7twgjp6	<NULL>	Good oral and general health; be at least 18 years of age; probing depth less than 3 millimeters, dentin sensitivity; have at least 2 teeth and a maximum of 4 teeth with non-carious cervical lesions	Patients with advanced periodontal disease; severe or chronic periodontitis; bruxism; Pregnant or lactating participants; participants in chronic use of anti-inflammatory, analgesic or psychotropic drugs, patients with dental fractures, or with unsatisfactory restorations or deep caries or who use fixed, removable or total partial dentures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-5v6dsj	Clinical evaluation of posterior teeth restorations with bulk-fill resin composites	Recruitment completed	Intervention	2015-09-02	<NULL>	<NULL>	4453	Clinical evaluation of class I e II posterior restorations with high-viscosity bulk-fill resin composites: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Faculdade de odontologia da Universidade de Pernambuco	Coordenação de aperfeiçoamento de pessoal de nível superior	https://ensaiosclinicos.gov.br/rg/RBR-5v6dsj	<NULL>	Adolescents from public state schools; Age between 12-18 years, presence of three vital teeth, either decayed or with unsatisfactory restorations (Black Class I or II cavities); the presence of occlusal and proximal contacts; good general health; and no contraindication to dental treatment.	Advanced periodontal disease, non-carious cervical lesions in the teeth selected for the study, posterior teeth with pulpal alterations, teeth endodontically treated, or pulp exposure during the removal of carious tissue, teeth with a history of pain. Smokers and individuals with potential behavioral problems that would not cooperate during interventions were also excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-6rp3ds	Clinical evaluation of previous use of local anesthetic anti-inflammatories in pain control after canal treatment;	Recruitment completed	Intervention	2016-12-29	<NULL>	<NULL>	1129	Evaluation of premedication with anti-inflammatory and anesthetic solution in the control of post-endodontic pain;	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6rp3ds	<NULL>	Healthy volunteers; both genders; age between 18 and 60 years; signed consent form; endodontic treatment needs; symptomatic; ability to understand the pain scales and questionnaires.	Use of analgesics or anti-inflammatories drugs within 12 hours before the endodontic procedure; acute dento-alveolar or periodontal abscess; needs of antibiotic prophylaxis; pregnant or lactating; mental disability; systemic alterations or allergies that contraindicate the use of the anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-2ygk8xs	Clinical evaluation of Prostheses on implants installed by different techniques (Guided and Conventional)	Recruitment completed	Intervention	2023-02-18	<NULL>	<NULL>	7125	Randomized clinical evaluation of Protocol/Overdenture-type Prostheses on morse taper implants installed by Guided versus Non-guided Technique	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-03	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista	Dentscare LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2ygk8xs	<NULL>	Health patients; both genders; who presents loss of dental elements indicated for extractions due to root fractures, caries, endodontic lesions or periodontal disease, who remain totally edentulous at the end of the maxillary indications for rehabilitation with prostheses type protocol or overdenture; presence of adequate bone volume for indication of rehabilitation, confirmed by complementary exams; no systemic contraindications for intraoral surgical therapy; good oral hygiene; over 18 years old	Patients using medication that contraindicates the installation or changes the osseointegration of implants; presence of bone grafts in the planning area made previously that make it difficult to install implants; unfavorable bone conditions for implant placement in previous exams, bone availability for implants smaller than 8.5 mm or with predictable fenestrations in any bone wall that cannot be circumvented during surgery; pregnant or breastfeeding women and compulsive smokers more than 2 packs per day	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-8s5vqbb	Clinical evaluation of Resin Restorations in teeth with abfraction	Not yet recruiting	Intervention	2022-09-30	<NULL>	<NULL>	5644	Clinical evaluation of direct Adhesive composite resin Restorations in abfraction dental lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-08	Universidade do Estado do Rio Grande do Norte	Faculdade de Enfermagem e Medicina Nova Esperança	https://ensaiosclinicos.gov.br/rg/RBR-8s5vqbb	<NULL>	Patients of both biological sexes; age between 18 and 50 years; good general health and satisfactory oral hygiene; with at least 20 teeth; with dental retainer; diagnosis of at least two abfraction lesions with at least 1 mm of depth, in different premolars located in different hemi-arches, in occlusion and which have opposing teeth; sound premolars or with satisfactory restorations in an area different from the abfraction lesion; no nearby gingival inflammation or periapical changes	Patients in need of use of dental prosthesis with the edentulous space adjacent to the dental elements that could be included in the research; caries diagnosis coinciding with the abfraction lesion or endodontic treatment indication; diagnosis of severe parafunctional habits; presence of moderate or severe periodontal involvement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-7hbmjp	Clinical evaluation of resin restorations of posterior teeth performed at the são luis dental specialty Center - randomized clinical trial	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3773	Retrospective evaluation and randomized clinical trial of posterior direct restorations performed in dental specialty centers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-04	Suellen Nogueira Linares Lima	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-7hbmjp	<NULL>	Need restorative treatment with composite resin on 2 posterior teeth; aged between 18 and 70 years; agree to participate in the study; having a medical history that does not compromise the evolution of the results; having the habit of oral hygiene that involves brushing at least twice a day; having a normal periodontal condition in relation to the probing parameters.	Patients with a chronic disease with oral manifestations; present any oral pathology considered serious; high caries activity; severe periodontal problem that may compromise the direct restoration of the posterior tooth; allergies to any material that will be used at work; signs or symptoms of bruxism and dental clenching; teeth that will be used as a pillar for removable dentures or fixed partial dentures; teeth with porcelain restoration directly opposite the tooth that will receive the research restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-9xdn99g	Clinical evaluation of restoration for dental restoration near the gum before and after in-office bleaching	Recruiting	Intervention	2025-02-06	<NULL>	<NULL>	7876	Color matching of unichromatic composite resin before and after in-office bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9xdn99g	<NULL>	Good general health; good oral hygiene; present at least 20 teeth under occlusion; at least two non-carious cervical lesions comparable in size, shape and dimensions; non-retentive; deeper than half a millimeter; involve both the enamel and dentin of vital teeth; the cavosurface margin cannot involve more than 50% of the enamel; never having undergone dental whitening	Extremely poor oral hygiene; wearing orthodontic appliances; severe or chronic periodontitis; heavy bruxism habits; known allergy to resin-based materials or any other material used in this study; pregnant or lactating women; chronic use of anti-inflammatory, analgesic and psychotropic drugs; patients who have already undergone dental whitening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-6j3x5q	Clinical evaluation of restorations carried out on newly whitened teeth	Not yet recruiting	Intervention	2016-08-25	<NULL>	<NULL>	974	Clinical evaluation of an antioxidant on bond strength of esthetic restorations in newly whitened teeth	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-05	Universidade Estadual de Maringá	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6j3x5q	<NULL>	Volunteers with canines and upper and lower premolars with non-carious lesions of abfraction, abrasion and erosion featuring color change A3 or higher by Vitapan scale; presenting at least 4 teeth on the sample, so that each tooth represents one of the groups; have at least 20 teeth in function and lesions that contain at least fifty percent of enamel margins.	Canines and bicuspids with endodontic treatment; who do not have the need to be restored; which suffered action of bleaching agents previously; with periodontal disorders; with active caries; with changes in the formation of enamel.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-7dm3sp7	Clinical evaluation of Restorations in Anterior Teeth with Composite Resin using the cloud shades concept	Not yet recruiting	Intervention	2022-11-14	<NULL>	<NULL>	5723	Clinical evaluation of Restorations in Anterior Teeth with Composite Resin using the cloud shades concept: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-02	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7dm3sp7	<NULL>	Two anterior permanent teeth requiring restorations in each patient (two class III or two class IV), large cavities or defective restorations with similar dimensions and including the same number of tooth surfaces; presence of the antagonist and opposing teeth making contact; vital pulp; good oral health, age between 18 and 70 years; both genders	Extremely deep caries lesions, unrestorable crown; mechanical pulp exposure during caries removal; teeth previously treated with direct pulp capping; teeth exhibiting spontaneous or constant pain indicating irreversible pulpitis; severe systemic diseases; allergies to dental composites; periodontal disease; deleterious parafunctional habits and bruxism; hypersensitivity on the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-63q9z47	Clinical evaluation of restorations located close to the gums using universal adhesives	Not yet recruiting	Intervention	2025-02-19	<NULL>	<NULL>	7765	Interaction of universal dentin bonding systems of non carious cervical lesions: a randomized clinical controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Clinica Multidisciplinar	https://ensaiosclinicos.gov.br/rg/RBR-63q9z47	<NULL>	Patients of any gender; at least 18 years old; good general health; acceptable oral hygiene; presence of at least 20 teeth in occlusion; two or more teeth (in occlusion, vital and without mobility) with similar cervical lesions predominantly caused by Erosive Tooth Wear and with a supragingival margin	Caries activity; systemic health complications; active or chronic periodontal disease; severe bruxism or other parafunctional habits; patients using a complete denture or implants occluding with the teeth of interest; patients who have undergone orthodontic, hypersensitivity or whitening treatment in the last 6 months; pregnant or breastfeeding women; allergies to the main components of the products used in this study; unavailability of time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-989h4f	Clinical evaluation of restorations of posterior teeth using different types of composite resins	Data analysis completed	Intervention	2018-06-19	<NULL>	<NULL>	1914	Evaluation of admira fusion vs admira fusion xtra resins in posterior teeth restorations: randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-989h4f	<NULL>	Presence of cavities, fractures or cosmetic demands; first or second molars and permanent premolars needing restorations; should be performed at least two Class II restorations in each patient (the number of restorations of each material should be equal in each patient); presence of the antagonist and the adjacent tooth making contact; pulp vitalized and absence of painful symptoms; teeth that have never been subjected to direct pulp capping; no history of hypersensitivity in the teeth to be restored; size of the isthmus with no more than 2/3 of the intercuspal distance; permanent dentition.	Presence of deleterious habits and bruxism;  bad oral health and presence of periodontal disease; patients who are suffering from severe systemic diseases or allergies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-3z5tbf	Clinical evaluation of restorations performed on tooth and outside the mouth using flexible die technique	Data analysis completed	Intervention	2019-01-01	<NULL>	<NULL>	2419	Clinical evaluation of direct and semidirect restorations using flexible die technique	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-07	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-3z5tbf	<NULL>	Class II restorations; oral hygiene properly; absence of parafunctional habits, systemic diseases, periodontal disease, removable protesis involving the tooth studied or antagonist; presence of antagonist tooth and adjacents.	Tooth sensitivity; Allergy to resin based on materials or other materials used in this study; Pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-9w5p8q	Clinical evaluation of restorations using a new resin composite	Data analysis completed	Intervention	2019-03-20	<NULL>	<NULL>	2530	Clinical Evaluation of Class II restorations using a composite resin containing the ormocer monomer. Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-9w5p8q	<NULL>	Class II restorations; oral hygiene properly; absence of parafunctional habits, systemic diseases, periodontal disease, removable protesis involving the tooth studied or antagonist; presence of antagonist tooth and adjacents.	Tooth sensitivity; Allergy to resin based on materials or other materials used in this study; Pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-86t94mn	Clinical evaluation of restorations using an Universal Adhesive and a surface treatment	Recruitment completed	Intervention	2024-03-30	<NULL>	<NULL>	6903	Evaluation of the longevity of direct restorations of non-carious Cervical Lesions using a Universal Adhesive and surface pretreatment. Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-25	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-86t94mn	<NULL>	Volunteers at least 18 years of age; both genders; in good general health; with at least 4 teeth (premolars or molars) with non-carious cervical lesions with a depth and extension of at least 1 mm, vital and without mobility; with at least 20 teeth in occlusion	Volunteers with medical conditions that may interfere with the volunteer&apos;s health, such as allergic reactions to substances or products that will be used; use of a removable prosthesis with a clip on the tooth that will be used in the research; active caries lesions and/or defective restorations in the tooth to be analyzed and/or with periodontal disease; severe bruxism; professional desensitizing treatment in the last 6 months on the tooth that will be used in the research; research participants who are pregnant or breastfeeding; research participants undergoing orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-9yjjxvq	Clinical evaluation of the addition of antifungal drugs to denture liner material in the treatment of oral candidiasis	Recruitment completed	Intervention	2022-03-21	<NULL>	<NULL>	5293	Clinical evaluation of the addition of antifungals to temporary resilient liner in the denture stomatitis treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Karin Hermana Neppelenbroek	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9yjjxvq	<NULL>	Volunteer users of conventional removable upper denture; clinical diagnosis for denture stomatitis in the palatal mucosa supporting the complete denture, both genders, any age, regardless of the condition of the mandibular arch and the use and status of the lower denture.	Volunteers with anemia; immunocompromised; with uncontrolled endocrinopathologies; in a therapeutic regimen with antibiotics, steroids or antifungals in the last three months; under antineoplastic treatment by radio or chemotherapy; users of the same upper complete denture for over 30 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-5dhhhdd	Clinical evaluation of the antidepressant effect of the use of probiotics in bipolar disorder	Not yet recruiting	Intervention	2021-10-15	<NULL>	<NULL>	5671	Clinical evaluation of the antidepressant effect of the use of probiotics in bipolar disorder and possible mediating effects of systemic and Intestinal Inflammatory markers in the microbiota	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dhhhdd	<NULL>	Bipolar disorder type I or type II; score on the YMRS scale less than 8; score on the MADRS scale greater than 8	"Pregnant or lactating women; patients dependent on alcohol and illicit drugs like marijuana, crack or cocaine; patients on prolonged antibiotic therapy; immunosuppressive therapies; introduction of recent antidepressants up to 15 days from the beginning of the study; HIV carriers with manifestations of the syndrome
of acquired immunodeficiency and serious clinical diseases; with delayed mental or inability to understand the study instructions will be excluded"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-772thc	Clinical evaluation of the effect of epigallocatechin-3-gallate in the restorative treatment of non-carious lesions	Recruitment completed	Intervention	2020-05-14	<NULL>	<NULL>	3834	Clinical evaluation of the effect of Epigallocatechin-3-gallate in the restorative treatment of Abfraction lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Lisiane Martins Fracasso - Financiamento Próprio	FORP - Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-772thc	<NULL>	"Patients between 18 and 60 years old;
Patients with satisfactory general health and oral hygiene;
Patients who have at least 20 teeth under occlusion;
Presence of at least two abfraction lesions in two homologous premolars;
The lesions must be shallow or medium, involving enamel and dentin;
Teeth must be positive result to the thermal test;"	"Patients with periodontal disease, spontaneous pain and / or tenderness, fistula and / or edema;
Patients with occlusal problems"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-7b7cmn	Clinical evaluation of the effect of the combination of Potassium Nitrate 5% and desensitizing agent-based glutaraldehyde in the prevalence of post-bleaching sensitivity	Recruiting	Intervention	2016-05-28	<NULL>	<NULL>	868	Clinical evaluation of the effect of the combination of Potassium Nitrate 5% and desensitizing agent-based glutaraldehyde in the prevalence of post-bleaching sensitivity	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7b7cmn	<NULL>	Candidates must have all the teeth of the upper and lower canine; canine without manifestations of caries and/or restorations; exposed dentin and spontaneous tooth sensitivity; able to sign a consent form; over 18 years; Commit to attend for regular examinations; having good conditions of oral and general health; central incisors to A2 or darker color.	Pacientes who have previously done some bleaching procedure; pregnant or lactating; smokers, patients with tetracycline stains, fluorosis or endodontic treatment; patients with severe periodontitis and bruxists; use of any medication with anti-inflammatory or antioxidant action.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-9jqdgq	Clinical evaluation of the effects of esmolol and magnesium sulfate to avoid tachycardia and arterial hypertension during intubation in surgeries	Recruitment completed	Intervention	2017-11-08	<NULL>	<NULL>	1471	Clinical evaluation of the effects of esmolol and magnesium sulphate on the hemodynamic response to tracheal intubation	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-04-18	Universidade do Sul de Santa Catarina	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-9jqdgq	<NULL>	Functional class I and II patients, according to the American Society of Anesthesiologists (ASA); submitted to elective surgery; of both sexes; aged between 18 and 65 years; who agree to participate in the study	Patients with difficult airway; obesity with BMI&gt; 35; in the use of beta-blockers or calcium channel blockers; with heart rate less than 60 bpm; cardiac arrhythmias, renal dysfunction, airway hyperreactivity, hypersensitivity to esmolol or magnesium sulfate; and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-46vshg	Clinical evaluation of the influence of calcium and fluoride  based mouthrinses in reducing tooth sensitivity and the effectiveness of color change during in-office bleaching	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2552	Clinical evaluation of the influence of calcium lactate and fluoride solution mouthrinses in reducing tooth sensitivity and the effectiveness of color change during in-office bleaching	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-20	São Leopoldo Mandic	São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-46vshg	<NULL>	Including criteria: ageded 18 to 30 year, the presence of at least 20 teeth and presence of elements 13, 12, 11, 21, 22, 23, 33, 32, 31, 41, 42, 43 sound or at most 1/6 restores labial surface.	Exclusion criteria: teeth with initial teeth color assessed by spectophotometer (VITA Easyshade® Advance, Vita, Germany) B1, removable or fixed prosthesis and orthodontic appliances users, pregnant or breastfeeding, smokers, previous dentin sensitivity, generalized gingival retraction or above 2mm, presence of active caries lesions in enamel and dentin, presence of periodontal inflammation and other oral lesions, tetracycline-pigmented teeth and patients who received previous bleaching treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-8yjfpmk	Clinical evaluation of the match and color stability between one shade composite resin and teeth	Recruiting	Intervention	2023-07-13	<NULL>	<NULL>	6238	Clinical evaluation of the match and color stability of monochromatic composite resin – randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-8yjfpmk	<NULL>	Adults presenting a non-carious cervical lesion with indication for class V restoration on the buccal surface; Having non-carious cervical lesions in different quadrants; No pain or pulp alteration in the tooth to be restored; Consent to participate in the research	Severe or active periodontal disease; Use fixed orthodontic appliance; rampant caries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-4mdcbcg	clínical evaluation of the plastic retainers on speech	Recruitment completed	Intervention	2024-12-03	<NULL>	<NULL>	7556	clínical evaluation of the plastic retainers on speech patterns	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Centro Universitário da Fundação Hermínio Ometto	Centro Universitário da Fundação Hermínio Ometto	https://ensaiosclinicos.gov.br/rg/RBR-4mdcbcg	<NULL>	Volunteers treated with angle class I malocclusion with mild or moderate crowding; who has received orthodontic treatment without extraction; with fixed lip appliance on both arches; exposed to a monolingual environment	Overhang greater than 4 mm; anterior open bite malocclusion; anterior or posterior crossbite malocclusion; changes in speech production; tongue protrusion habit; cleft lip or palate; surgical correction of the jaws; hearing disorder; presence of temporomandibular dysfunction; presence of severe periodontitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-4gt5jh2	Clinical Evaluation of the Survival Rate, Surface Wear and Color Stability in crowns on the teeth made of different Ceramic Materials	Recruitment completed	Intervention	2022-10-11	<NULL>	<NULL>	5657	Prospective split-mouth Clinical Study of Monolithic Zirconia and Metal-ceramic Crowns on teeth comparing Survival, Surface Wear and Color Stability	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-05	Alessandra Sayuri Tuzita	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4gt5jh2	<NULL>	Be over 18 years of age; presence of antagonist teeth, which showed differences substrates due to the difficulty of screening; mutually protected occlusion with correct curvatures of Spee and Wilson and absence of loss of vertical dimension of occlusion; and presence of adequate insertion bone.	Presence of decompensated systemic diseases; heavy smoker (more than 10 cigarettes/day); presence of severe periodontal disease; pregnant or lactating women; history of serious psychological illness.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-3www35z	Clinical Evaluation of the Truenat Point-of-care Tuberculosis Diagnostic Test	Not yet recruiting	Observational	2020-11-25	<NULL>	<NULL>	4432	Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Departamento de Ciência e Tecnologia - DECIT. Secretaria de Ciência, Tecnologia e Insumos Estratégicos – SCTIE, Ministério da Saúde-MS (SCTIE/MS)	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3www35z	<NULL>	Age 18 years or above; Clinical suspicion of pulmonary TB (including cough for at least 2 week and at least 1 other symptom typical of TB); Willingness to provide 3-4 sputum specimens at enrolment; Willingness to have a trial follow-up visit approximately 2 months after enrolment; Provision of informed consent.	"Case Detection Group:Receipt of any dose of TB treatment within 60 days prior to enrolment (even if within last two days only).
Drug Resistant TB Group: Receipt of any dose of MDR-TB treatment within 60 days prior to enrolment (even if within last two days only)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:11
RBR-8dy2k2w	Clinical Evaluation of the use of alveolar protection devices in healing after tooth extractions.	Recruitment completed	Intervention	2021-02-25	<NULL>	<NULL>	4559	Clinical Evaluation of the use of alveolar protection devices in healing after tooth extractions.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	São Leopoldo Mandic	São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-8dy2k2w	<NULL>	At least one tooth with indication of extraction in the regions of premolars and or lower and or upper molars without bone defects.	Contraindications for oral surgery; smokers of more than 10 cigarettes a day; pregnant or nursing women; need for grafting; maxillary sinus diseases when extraction is in the upper arch.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-7xpkjhk	Clinical evaluation of the use of Lasers and LEDs for facial rejuvenation	Recruitment completed	Intervention	2024-11-11	<NULL>	<NULL>	7501	Effect of low-intensity light sources on improving skin quality: randomized, controlled, blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	https://ensaiosclinicos.gov.br/rg/RBR-7xpkjhk	<NULL>	Female patients; aged between 35 and 70 years; and presenting type II and III expression lines on the Glogau scale	Pregnant patients; who have dermatitis; or skin neoplasms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-2h9qkd	Clinical evaluation of tooth restoration using an agent by only one insertion	Recruitment completed	Intervention	2020-01-27	<NULL>	<NULL>	3400	Clinical behavior of single increment composites: randomized controlled longitudinal study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Faculdades Integradas Pitágoras de Montes Claros	Universidade de Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-2h9qkd	<NULL>	over 18 years old; patients who had posterior teeth with active and / or cavitated caries lesions, requiring restoration with direct restorative material, but free of proximal caries according to interproximal radiographic examination; patients who already had class I restorations within score 5 (Clinically poor: International Dental Federation - IDF) on at least one of the following criteria: surface gloss; surface and margin staining; combination of color and translucency; anatomical form; fracture and retention of material; marginal adaptation; patient satisfaction; postoperative sensitivity; recurrence of caries.	patients contraindicated for dental treatment due to their medical history; xerostomia patients or who were taking medication that significantly reduced salivary flow; patients with parafunctional habits of bruxism and teeth clenching and / or attrition; patients who did not have teeth antagonist to the element indicated for the restorative procedure; patients with endodontically treated teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-4s4jv7v	Clinical evaluation of tooth whitening with violet light	Recruiting	Intervention	2025-10-31	<NULL>	<NULL>	8477	Long-term clinical evaluation in-office dental bleaching using violet LED light (405-410 nm)	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-22	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	<NULL>	<NULL>	<NULL>	Minimum age of 18 years and maximum age of 30 years; presence of all dental elements, without aesthetic restorations or caries lesions in the upper and lower anterior teeth; and participants with canine tooth color of A3 or darker, according to the VITA® Classical Color Scale	Presence of any type of systemic pathology; presence of periodontal disease; systematic use of tobacco and alcoholic beverages; participants with teeth discolored by tetracycline, fluorosis, endodontic treatment; participants with a history of self-reported tooth sensitivity; pregnant or breastfeeding female participants; presence of crowns or restorations on the anterior teeth (15 to 25 and 35 to 45); and participants with bruxism or undergoing treatment with medication with anti-inflammatory, analgesic and/or antioxidant action	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:29
RBR-2s5bhm	Clinical evaluation of two restorative approach for non-carious cervical lesions	Data analysis completed	Intervention	2018-06-20	<NULL>	<NULL>	1916	Clinical evaluation of Class V restorations using a semi direct technique - a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Instituto de Ciência e Tecnologia de São José dos Campos (ICT/SJC) - Universidade Estadual Paulista (UNESP)	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-2s5bhm	<NULL>	"• Be at least 18 years of age;
• Provide good general health;
• Do not introduce active decay or periodontal disease;
• Class V lesions, non-carious in canines premolars or with a minimum depth of 1 mm."	Medical condition that might interfere with the safety of the volunteer during the study period, or allergic reaction to substances and/or products used in the study; use of removable prosthesis with clamp resting on the study tooth; presence of caries or periodontal disease; patients under orthodontic treatment; tooth with endodontic treatment; smoking patients, patients with parafunctional habits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-5w8bgmk	Clinical Evaluation of two Unicrhomatic Resins in Non-Carious Cervical Lesions	Recruitment completed	Intervention	2025-07-07	<NULL>	<NULL>	8102	Clinical evaluation of two Unicrhomatic Resins in Non-Carious Cervical Lesions: a randomized, triple-blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5w8bgmk	<NULL>	Patients ASA (American Society of Anesthesiologists classification) I and II; age between 18 and 65 years; good oral hygiene; may be male or female; present at least 20 teeth in occlusion; present at least 2 NCCLs (Non-carious cervical lesions), with a depth greater than 1 mm	People with periodontal disease (probing depth up to 3 mm, bleeding, or mobility up to grade II); people with parafunctional habits; smokers; patients with orthodontic appliances; teeth that serve as prosthetic abutments; pregnant women; people who do not agree with the terms of the research or who have difficulties attending the follow-up appointments after the restoration is performed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-48zgwz5	Clinical evaluations of conventional and digital provisional removable partial dentures	Recruiting	Intervention	2025-02-04	<NULL>	<NULL>	7705	Conventional vs. digital provisional removable partial dentures: a randomized controlled crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-48zgwz5	<NULL>	Patients of both sexes; aged 18 or older; partially edentulous; who are interested in participating in the study for the installation of interim removable partial dentures; and who present good general health conditions	Patients with palatal or mandibular torus requiring surgical removal; cognitive disease; communication difficulties and who have trouble attending the university for prosthetic treatment and follow-up appointments; patients with temporomandibular dysfunction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-6xww44w	Clinical interventions in the care of hospitalized newborn	Recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7136	Clinical interventions in the care of hospitalized newborn: protection and promotion of neurodevelopment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual de Feira de Santana	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-6xww44w	<NULL>	Gestational age less than 37 weeks; after seven days of life; clinically stable (heart rate between 120 and 180 beats per minute, respiratory rate between 35 and 60 breaths per minute and oxygen saturation greater than or equal to 95% in the last 24 hours); kept inside incubators; 24 hours after the end of phototherapy treatment; both genders	In phototherapy; using invasive and non-invasive mechanical ventilation; with any type of congenital malformation; with periventricular hemorrhage grades II, III and IV; using central nervous system depressant medications, opioid analgesics and sedatives in the last 24 hours; using corticosteroids; in need of surgery of any nature; whose mother has a history of using any illicit drugs or antidepressants during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-98r97j	Clinical investigation in deciduous teeth using Bulk Fill flow resin.	Recruitment completed	Intervention	2017-06-12	<NULL>	<NULL>	2771	Randomized double blind clinical trial using Bulk Fill flow resin in deciduous teeth by minimally invasive technique: three years of follow-up.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-98r97j	<NULL>	Healthy volunteer children; Both genders; Duly enrolled in municipal or state schools; With an acceptable oral hygiene level; With a minimum of 6 years and a maximum of 9 years.	Children who do not accept oral examination or restoration; Those that are missing on the scheduled restoration day; Those whose managers do not sign the Free and Informed Consent Form; Teeth with very deep carious lesions; Fistulated teeth; With such spontaneous pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-74qm3m	Clinical investigation of a photography-aided behavioral intervention to reduce risk factors for caries and malocclusion (bad bite&quot; in high-risk infants	Recruitment completed	Intervention	2018-05-01	<NULL>	<NULL>	1746	Role of the Dental Surgeon in a Neonatology Service in a Public Maternity Hospital in Goiânia-GO	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Hospital Maternidade Dona Iris	Hospital Maternidade Dona Iris	https://ensaiosclinicos.gov.br/rg/RBR-74qm3m	<NULL>	Mothers of healthy children born from August 1st to 31th, 2015.	Low gestational age at birth (defined as younger than 37 weeks of gestation). Low birth weight (defined as children born weighing less than 2,500 grams). Suspected congenital malformations. Any infectious disease. Twin pregnancies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9q35d6n	Clinical longevity of impression-made composite resin restorations and out-of-mouth restorations in destroyed teeth: a clinical study	Not yet recruiting	Intervention	2024-11-22	<NULL>	<NULL>	7533	Clinical longevity of composite resin restorations obtained by 3D printing and semi-direct restorations in extensively destroyed teeth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-30	Universidade Federal de Pelotas - Faculdade de Odontologia	Universidade Federal de Pelotas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-9q35d6n	<NULL>	Indicate extensive restoration in posterior teeth (molar and premolar); be in good general health to undergo dental treatment; and; agree to participate in the study by signing an informed consent form; both sexes	Patients who do not have at least 12 posterior teeth in occlusion; patients who are undergoing orthodontic treatment or planning to undergo orthodontic treatment; patients with a systemic disease that prevents dental treatment; patients not available for follow-up appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-9fkncwv	Clinical monitoring of patients with heart failure	Not yet recruiting	Intervention	2024-02-26	<NULL>	<NULL>	6810	Effectiveness of clinical monitoring in the Transition of patients with Heart Failure between health care networks: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9fkncwv	<NULL>	Adults more than 18 years old; with decompensated heart failure with a minimum left ventricular ejection fraction lower than 40 percent; possibility of access to cell phones to receive video calls	Patients on the heart transplant waiting list; who have undergone surgical or percutaneous treatment (coronary or valve) in the last 3 months and with heart failure considered terminal or in palliative care confirmed in medical records; patients with other serious clinical comorbidities with life expectancy less than 1 year confirmed in medical records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-10t84b5s	Clinical outcomes and costs of the use of Fibrin Glue in Pancreatic Surgery	Data analysis completed	Intervention	2021-04-05	<NULL>	<NULL>	4603	Impact of the use of Fibrin biological glue sealant on the reinforcement of Pancreatic anastomosis after Duodenopancreatectomy	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Hospital das Clínicas Faculdade de Medicina Ribeirão Preto	Hospital das Clínicas Faculdade de Medicina Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-10t84b5s	<NULL>	both sexes; any age; undergoing duodenopancreatectomy	There is not	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:27
RBR-10jc7w38	Clinical performance of a composite resin with intelligent chromatic technology for the restoration	Recruitment completed	Intervention	2022-09-02	<NULL>	<NULL>	5590	Clinical performance of a composite resin with intelligent chromatic technology for the restoration of non-carious cervical lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-10jc7w38	<NULL>	Good general health; good oral hygiene; have at least 20 teeth under occlusion; at least two comparable non-carious cervical lesion (in size; shape and dimensions); non-retentive; deeper than 0.5 mm; and involving both enamel and dentin of vital teeth; the cavo-superficial margin cannot involve more than 50% of the enamel.	Extremely poor oral hygiene; using orthodontic devices; severe or chronic periodontitis; heavy bruxism habits; known allergy to resin-based materials or any other material used in this study; pregnant or lactating women; chronic use of anti-inflammatory; analgesic and psychotropic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-426n79	Clinical Performance of Antiseptic Anti-stain	Data analysis completed	Intervention	2017-09-21	<NULL>	<NULL>	4448	Clinical Performance of Antiseptic Copolymer Whitening - Clinical Study Randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Faculdade de Odontologia de Araraquara	Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-426n79	<NULL>	Volunteers of both genders; older than 18 years; that have at least 20 natural teeth in the oral cavity, being incisors and the superior canines without caries, restorations or prostheses.	Pregnant and lactating;patients with systemic diseases; xerostomia; acid erosion; bruxism; mouth breathing; dental crowding; patients undergoing orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-58hnx64	Clinical performance of Ceramic Dental Crowns	Not yet recruiting	Intervention	2023-05-16	<NULL>	<NULL>	6083	Clinical performance of Zirconia Monolithic Implant-Supported Single Crowns: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-58hnx64	<NULL>	"Volunteers that require tooth replacement with an implant-supported single crown in one posterior quadrant in the maxilla or mandible; age from 18 to 70; good oral hygiene;	periodontal health or successful periodontal therapy; at least one adjacent tooth/restoration; presence of antagonistic contacts"	Volunteers with dental implants exhibiting biologic complications before the fabrication of the definitive implant-supported single crown; severe parafunctional habits; lack of occlusal stability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-8hmqbmf	Clinical Performance of Complete Crowns in Printed Resins obtained by Digital Flow in dentistry	Not yet recruiting	Intervention	2023-03-01	<NULL>	<NULL>	5928	Performance of Full Crowns in Printed Resins obtained by CAD/CAM System. Clinical, controlled, triple blind and randomized study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-06	Faculdade de Odontolologia da Universidade Federal de Uberlândia	Faculdade de Odontolologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8hmqbmf	<NULL>	Adult patients aged 18 years or older; both genders; in need of a single crown in a posterior tooth(s) with major coronary destruction; that the tooth has pulp vitality or satisfactory endodontic treatment; with or without intraradicular retainer; that has a medical history that does not compromise the evolution of the results; that has the habit of brushing the teeth at least once a day; that has normal periodontal condition front to probing parameters; has occlusal stability	Patients younger than 18 years old; with some chronic disease with oral manifestations; who present some oral pathology considered serious; with signs and/or symptoms of parafunction (clenching and/or bruxism); with no oral hygiene; with periodontal disease; with allergies to any material that will be used in the study; smokers; or any other condition that may indirectly interfere with the primary and/or secondary outcomes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-7khws8d	Clinical performance of composite resin restorations in Non-Carious Cervical Lesions	Recruitment completed	Intervention	2025-04-17	<NULL>	<NULL>	7935	Clinical performance of restorations of non-carious cervical lesions in posterior teeth with bulk-fill composite resins: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7khws8d	<NULL>	Presence of 4 vital teeth with non-carious cervical lesions on the vestibular surface of premolars and molars; age range from 18 to 64 years; both sexes; present at least 20 teeth; occlusal contact with healthy or properly restored antagonist tooth	Advanced periodontal disease; teeth with pulp alteration or endodontic treatment; participants undergoing orthodontic treatment; severe bruxomas; smokers; participants who make chronic use of analgesics; teeth with tissue loss in the cervical region due to carious lesions; participants with a thin gingival biotype; medical, psychiatric or pharmacotherapeutic history that may compromise the protocol, including chronic use of anti-inflammatory, analgesic and psychotropic drugs; pregnancy or breastfeeding; allergies and idiosyncratic responses to the composition of the products; abutment teeth of fixed or removable prostheses; teeth or support structures with any painful pathology; poor oral hygiene	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-8yqbfr	Clinical performance of flowable resin composites with bioactive technology and resin-modified glass ionomer cement in noncarious cervical lesions of abfraction: a randomized control clinical trial	Not yet recruiting	Intervention	2020-08-31	<NULL>	<NULL>	4191	Clinical performance of flowable resin composites with Giomer technology and resin-modified glass ionomer cement in abfraction lesions: a randomized control clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-10	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8yqbfr	<NULL>	Participants must be between 18 and 65 years of age; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep.	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-5ntdwg	Clinical Performance of regular resin composite with bioactive technology and resin-modified glass-ionomer in restorations of cervical lesions of Abfraction: a randomized controlled clinical trial	Not yet recruiting	Intervention	2020-09-11	<NULL>	<NULL>	4243	Clinical Perfomance of regular resin composite with S-PRG technology and resin-modified glass-ionomer in restorations of Cervical Lesions with predominance of Abfraction: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5ntdwg	<NULL>	Participants must be between 18 and 65 years of age; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep.	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-389y6y	Clinical performance of resin-modified glass-ionomer cements + 45S5 in permanent molars:  randomised controlled clinical trial	Recruitment completed	Intervention	2018-12-04	<NULL>	<NULL>	4677	Prevention of carious lesions with  resin sealant and resin-modified glass-ionomer cements: randomised controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-389y6y	<NULL>	Healthy volunteers; both genders; age between 8 and 14 years; permanent molars with non-cavitated visual caries lesions located between the enamel and dentin junction and the middle third of the dentin (ICDAS 3 and 4).	Volunteers with physical and mental problems; systemic diseases and that use medication in a controlled way. Patients who present with periodontal disease, or who in teeth submitted for the intervention present restoration or cavitation in any of its surfaces; or that present a painful sensation to any type of stimulus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-4pk34zm	Clinical performance of restorations using fibers in teeth with treated canals: randomized clinical trial	Not yet recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7562	Clinical performance of fiber-based restorations in endodontically treated teeth: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-16	Faculdade de Odontologia da Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4pk34zm	<NULL>	Being men and women; at least 18 years of age; in good general and oral health; the dental elements of the study must: have a posterior tooth, with satisfactory endodontic treatment; have loss of at least one proximal wall (occluso-mesial, occluso-distal, mesio-occluso-distal cavity); being in occlusion and having adjacent teeth; have a coronary structure remaining from the buccal or palatal/lingual walls with at least one cavity wall with a thickness of less than 2 mm	Patients with poor oral hygiene; smokers; pregnant women; breastfeeding women; teeth that have color changes due to intrinsic factors (dentinogenesis and amelogenesis imperfecta, fluorosis, tetracycline);  periodontal disease; severe parafunctional habits; cervical lesions (carious and non-carious); active clasps of removable partial dentures on the tooth included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-7t4zxq	Clinical Performance of Total Ceramic / porcelain Crowns on Posterior Teeth	Recruiting	Intervention	2019-04-25	<NULL>	<NULL>	2632	Evaluation of the Clinical Performance of Posterior Total Crowns of Monolithic Ceramics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-14	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-7t4zxq	<NULL>	"Patients with good oral and systemic health;
Absence of parafunctional habit or controlled parafunctional habit;
 Proper oral hygiene;
Teeth in need of posterior unitary prosthesis, in which the dental remnant is vital or with satisfactory endodontic treatment;
 The remnant should have periodontal health and absence of periapical changes that may compromise the longevity of the treatment."	"Presence of severe periodontal disease;
Presence of removable prostheses in the 
antagonistic arch of the tooth to be treated or in the same arch;
Patients without occlusal stability or without posterior containment;
Edentulous spaces adjacent to the tooth to be restored;
Malocclusions"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-9wf5v4	Clinical performance of two different resins in dental cavity restoration	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4181	Evaluation of the clinical effectiveness of two resin compounds for the restoration of non-carious cervical lesions	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2019-01-13	Centro Universitário Católica de Quixadá	Centro Universitário Católica de Quixadá	https://ensaiosclinicos.gov.br/rg/RBR-9wf5v4	<NULL>	Voluntary patients of both sexes, aged between 18 and 60 years, who had at least two non-carious cervical lesions distributed in different hemiarchies. patients without periodontal disease and without veneers or veneers in the teeth affected by non-carious cervical lesions.	Patients with active caries lesion on the remaining teeth of the arch. Unsatisfactory restorations. Recent restorations involving the vestibular surface. Inadequate oral hygiene. Teeth with mobility. Use of orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-3bbwwjz	Clinical performance of two glass ionomer cements used as restorative materials in Atraumatic Restorative Treatment (dental restorations)	Data analysis completed	Intervention	2023-07-24	<NULL>	<NULL>	6264	Clinical evaluation of glass ionomer cements used in Atraumatic Restorative Treatment (ART)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3bbwwjz	<NULL>	Children and adolescents in good general health; aged between 10 and 15 years; both sexes; residents of the municipality of Sobral; present a collaborative behavior to carry out the clinical procedure; present at least one of the upper and/or lower permanent molars with cavitated dentin occlusal caries lesion accessible to manual instruments with a minimum opening of 0.9 mm; present the Informed Consent Term signed by the parents/guardians	Permanent molars with pulp exposure; fistula; abscess; pathological mobility; spontaneous pain; carious dentin lesion not accessible to hand instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-2jmbvt	Clinical performance of two types of dental restorations: atraumatic and conventional	Recruitment completed	Intervention	2016-07-07	<NULL>	<NULL>	911	Randomized clinical trial of Class II ART restorations in deciduous teeth, with and without proximal retentions, and in permanent teeth in comparison with composite resin	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-06	Faculdade de Odontologia de Bauru, da Usp	Faculdad de Odontologia Catolica de Córdoba	https://ensaiosclinicos.gov.br/rg/RBR-2jmbvt	<NULL>	"For Hypothesis I the children aged between 4 and 7 year with good general health and having class II cavities in deciduous teeth without pulp involvement or pain will be included.
For Hypothesis II the children aged between 8 and 12year; adolescent and adult between 13 and 44 year with good general health and 1 until 4 class II cavities  in permanent teeth without pulp involvement or pain will be included."	"For Hypothesis I the children presenting behavioral problems; teeth with signs of sepsis, mobility or paranormal occlusion habits and absence of contacts with opposing or neighboring teeth will be excluded.
For Hypothesis II the children; adolescents and adults presenting teeth with signs of sepsis; mobility; more than 4 class II cavities in permanent teeth or paranormal occlusion habits and absence of contacts with opposing or neighboring teeth will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-34r4dz	Clinical performance of whitening toothpaste	Data analysis completed	Intervention	2017-08-24	<NULL>	<NULL>	4447	Clínical performance of a new Whitening Dentifrice containing optimized abrasive particles, desensitizing agent and dyes for optical whitening effect - Clínical Randomized Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Faculdade de Odontologia de Araraquara	Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-34r4dz	<NULL>	"Volunteers of both genders; over 18 years of age; who have at least 20 natural teeth in the oral cavity; and at least 6 incisors and
Superior canines without caries; restorations or prostheses."	Pregnant women and infants will be excluded from the study; and volunteers with systemic diseases;  xerostomia; acid erosion; bruxism; touth breathing; dental crowding and orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-7tqc7k	Clinical pharmacology of tamoxifen in breast cancer patients	Data analysis completed	Observational	2018-07-23	<NULL>	<NULL>	2040	Tamoxifen population pharmacokinetics in breast cancer patients: metabolism study, genetic polymorphism, hormonal status and age	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-01-07	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7tqc7k	<NULL>	Breast cancer patients on adjuvant tamoxifen treatment for more than 80 days who have not been treated with other co-medications that may interfere with the study have been investigated. For the study, two groups of patients will be delimited according to age and hormonal status, being a premenopausal group (age less than 50 years) and another postmenopause (age higher than 60 years).	Patients with comorbidities that interfere with the metabolism of tamoxifen and the probe drugs were excluded; patients who have previously chemotherapy and / or target therapy; patients who have contraindications to the use of the probe drugs metoprolol, midazolam and fexofenadine; and psychiatric patients unable to understand ICF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7dz5y9x	Clinical potential of the product Desplac (Premium Oral Gel) in the prevention of Gingivitis and as an adjunct to scaling and root planing therapy	Recruitment completed	Intervention	2024-09-20	<NULL>	<NULL>	7361	Clinical and microbiological potential of the product Desplac (premium oral gel) in the prevention of Gingivitis and as adject to Scaling and Root Planning Therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-03	Universidade Guarulhos - UNG	Universidade Guarulhos - UNG	https://ensaiosclinicos.gov.br/rg/RBR-7dz5y9x	<NULL>	Men and women; between 18 and 65 years of age; good general health (absence of any condition that may constitute a risk to the subject during participation in the study, examples: heart problems, chronic kidney problems, etc.); willingness to provide information related to their medical history; minimum of 15 permanent natural teeth without crowns (excluding third molars); average initial gingivitis index of at least 1.5, as determined by use of the gingival index; present generalized periodontitis Stages II or III, Grades A or B, based on the criteria established by the American Academy of Periodontology (2018)	Presence of orthodontic bands; presence of removable partial dentures; oral pathology, chronic disease or history of allergy to the active principles of dentifrices; use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication, or daily analgesics within one month of starting the study or scheduled to start such intake during the course of the study; pregnant or breastfeeding women; allergy to oral care products, personal care products or their ingredients; prolonged use of antibiotics or therapeutic mouthwash at any time during the three months prior to study entry; need for prophylaxis with antibiotics; ongoing use of medications known to affect gingival tissues (ie, calcium channel blockers, phenytoin, cyclosporine); periodontitis (purulent exudate, tooth mobility and/or extensive periodontal attachment loss); probing depth greater than 4 mm; periodontal treatment in the last 12 months before the beginning of the study; smokers (at least 10 cigarettes/day for at least 5 years) and former smokers (at least 5 years ago); history of periodontal treatment in the last six months; continuous use of oral antiseptics; use of systemic antibiotics, corticoids, non-steroidal anti-inflammatory drugs, immunosuppressants, estrogen and estrogen receptor modulators, as well as drugs that may influence bone metabolism (alendronate, calcitonin and others) in the last six months; systemic disease that may alter host response to periodontal treatment (eg diabetes) or that requires prophylactic medication for dental treatment (eg mitral valve prolapse); allergy to oral care products, personal care products or their reporting ingredients; use of orthodontic appliances, and extensive prosthetic rehabilitations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-4v36p2h	Clinical predictors of recurrence and malignization of Oral Leukoplakia and Proliferative Verrucous Leukoplakia: a randomized clinical trial	Recruiting	Intervention	2024-06-01	<NULL>	<NULL>	7038	Clinicopathological and digital predictors of recurrence and malignancy of Oral Leukoplakia and Proliferative Verrucous Leukoplakia: a clinical study associated with artificial inteligence	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-18	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4v36p2h	<NULL>	We will select 60 patients diagnosed with oral leukoplakia (OL) and 60 patients with proliferative verrucous leukoplakia (PVL) through biopsy and histological analysis. Only patients presenting with OL and PVL located in any region in the oral cavity will be selected. It is estimated that the participants will be mostly male smokers over 50 years of age for the diagnosis of OL and non-smoking women over 60 years of age for the diagnosis of PVL.	We will excluded patients with a history of previous oral carcinomas, chemotherapy, or radiation therapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-58wdpvh	Clinical profile, physical and sensory aspects of patients with Blood Cancer	Not yet recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7561	Clinical profile, physical and perceptual aspects of Hemato-Oncology patients	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-58wdpvh	<NULL>	Both genders; age between 18 and 59 years old; diagnosis of hematological cancer; being treated for hematological cancer	Use of medications for pain, nausea or constipation before applying foot reflexology; present medical contraindication to practicing foot reflexology; pregnancy (1st trimester); diarrhea and/or vomiting; localized skin diseases on the feet; localized inflammation or edema in the feet;  fever; infectious diseases; extreme negative reaction to the application of foot reflexology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-68jndr9	Clinical Protocol for the Use of Noninvasive Respiratory Support in Acute Hypoxemic Respiratory Failure	Recruitment completed	Observational	2026-01-15	<NULL>	<NULL>	8764	Development and implementation of an assistance protocol for the use of non-invasive support in patients with acute hypoxemic respiratory failure as a quality improvement tool	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-07-21	Instituto Nacional de Infectologia Evandro Chagas - INI/Fiocruz	<NULL>	<NULL>	<NULL>	Age ≥ 18 years; use of HFNC during hospitalization	Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-25x5dn	Clinical reasoning skills for physical therapy students	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2205	Teaching clinical reasoning skills to physical therapy students: a controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-25x5dn	<NULL>	Physiotherapy course students enrolled in the new curriculum (which includes Integrated Practical Activities)	Students who are not enrolled in the new curriculum of physiotherapy course  which includes the discipline of Integrative Practical Activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-6xwc26	Clinical research in the treatment of the asthma crisis, at emergency room, comparing the ciclesonide &quot;bomb&quot;, in a dose of nine sprays, with hydrocortisone, corticosteroid injected into the vein	Recruitment completed	Intervention	2017-01-12	<NULL>	<NULL>	1147	Efficacy and effectiveness of inhaled Ciclesonide in the treatment of acute Asthma attack: double-blind randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2012-01-24	Universidade Federal de São Paulo-Escola Paulista de Medicina	Universidade Federal de São Paulo-Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-6xwc26	<NULL>	Asthmatic patients aged greater than 13 years, with no upper limit and of both sexes, diagnosed with asthma according to the criteria of the GINA (Global Initiative for Asthma), moderate or severe asthma,that is, with lower FEV1 50 %.	Excluded patients with a body temperature greater than or equal 37,8º; smoking; pregnant women; patients in psychiatric treatment or with a history of heart disease, liver, kidney or other diseases that prevent the use of corticosteroids; patients in the postoperative pulmonary resection in treatment for pulmonary tuberculosis or fungal infection, tracheostomy or mechanical obstruction of the trachea. Patients with myopathy or neurological sequelae (stroke or encephalopathy) that prevent the implementation of the measures necessary for the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-6hxhx7	Clinical research of pain during restorative treatment in adults using a topical anesthetic photoactivated	Recruitment completed	Intervention	2016-08-15	<NULL>	<NULL>	961	Clinical investigation of intraoperative pain in adults undergoing restorative treatment of non-carious lesions using a topical anesthetic photoactivated	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6hxhx7	<NULL>	Patients over 18 years; with good general and oral health; the premolar teeth should have restorative treatment indication not carious cervical; these non-carious lesions should involve two teeth in different quadrants.	Endodontically treated teeth; destroyed and caries; also excluded are patients with gingivitis; periodontitis and dental mobility; in addition, patients with a history of allergy; any form of sensitivity or allergic reaction to anesthetics and ester-based components of the formula; patients with severe uncontrolled systemic disease (heart problems; neurological; kidney; liver or blood); pregnant or lactating patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6dytyf	Clinical research of pain during treatment sealants in children using a new topical anesthetic photoactivated	Recruitment completed	Intervention	2016-08-16	<NULL>	<NULL>	962	Clinical evaluation of intraoperative pain in children undergoing preventive treatment using a new topical anesthetic photoactivated	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6dytyf	<NULL>	Children 8 to 12 years with good general and oral health; the teeth 36 and 46 should be fully erupted and have sealant indication.	Teeth that are unerupted or carious lesions that require restoration; also a history of allergy patients are excluded; any form of sensitivity or allergic reaction to anesthetics and ester-based components of the formula; severe systemic disease patients not controlled as heart problems; neurological; kidney; liver or blood and even patients not employees.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-4cs7kjz	Clinical research with cannabinoids low doses to treat Alzheimer&apos;s disease	Recruitment completed	Intervention	2021-05-07	<NULL>	<NULL>	4629	Clinical investigation with Cannabinoid microdoses for the treatment of Alzheimer&apos;s disease	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal da Integração Latino-Americana	Associação Brasileira de Apoio a Cannabis Esperança	https://ensaiosclinicos.gov.br/rg/RBR-4cs7kjz	<NULL>	60 years old or older; to be diagnosed with Alzheimer for at least 1 year	to have diagnostic of other dementias or correlated diseases; família historic of psychosis; ilegal psychoactive drugs use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-8zwgpyg	clinical Response of Joint Infiltration in Hip Osteoarthritis with Orthobiologics	Recruitment completed	Intervention	2024-03-21	<NULL>	<NULL>	6883	Joint Infiltration in Hip Osteoarthritis with Bone Marrow Aspiration: randomized clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2024-02-05	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8zwgpyg	<NULL>	Individuals who have had pain or swelling in the hip (symptoms relevant to hip joint pain) for at least 4 months; Kellgren-Lawrence grade between 1 and 3 on radiographic evaluation; over 18 years old; both genders	Patients who have undergone a corticosteroid hip joint infiltration within 3 months;  or a Hialuronic Acid -HA joint infiltration within 6 months or history of any of the following medical conditions:diabetes, autoimmune disorders, disorders that require immunosuppression, rheumatoid arthritis, infectious arthritis, history of cancer, neurological condition that compromises gait or any other that compromises the level of consciousness, ongoing infectious diseases, kidney and liver diseases and osteonecrosis of the femoral head with collapse secondary to sickle cell anemia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-82q4yf5	Clinical results using Latanoprost 0.005% (Xalatan®) compared to Latanoprost 0.005% (Arulatan®) eye drops in patients with   glaucoma or ocular hypertension	Recruitment completed	Intervention	2021-09-09	<NULL>	<NULL>	4876	A descriptive study of clinical results using Latanoprost 0.005% (Xalatan®) compared to Latanoprost 0.005% (Arulatan®) eye drops in patients with primary open-angle glaucoma or ocular hypertension	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-16	IPEPO - Instituto Paulista de Estudos e PEsquisas em Oftalmologia	IPEPO - Instituto Paulista de Estudos e PEsquisas em Oftalmologia	https://ensaiosclinicos.gov.br/rg/RBR-82q4yf5	<NULL>	Patients 18 years of age or older, both gender and of any race, diagnosed with open-angle primary glaucoma or ocular hypertension. Patients should be able to understand and sign the informed consent that has been approved by a Research Ethics Committee. After a 28-day washout, the patient should have intraocular pressure between 21mmHg and 36mmHg, to confirm eligibility	1. Fertile women are excluded from participating in the study if they meet any of the following conditions: currently pregnant or, present positive results in the urine pregnancy test at the Screening Visit or, plan to become pregnant during the study period or, are breastfeeding. Patients with severe central visual field loss. Severe central visual field loss is defined as a sensitivity less than or equal to 10 dB in at least 2 of the 4 visual field test points closest to the point of attachment. Patients who can not safely discontinue use of all ocular medications for IOP reduction for a period of 28 days ± 1 day prior to the Randomization Visit. Chronic, recurrent or severe inflammatory eye disease (ie, scleritis, uveitis, herpetic keratitis). Eye trauma in the last 6 months. Eye infection or eye inflammation in the last 3 months. Clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy or retinal detachment. Intraocular surgery in the last 6 months. Laser eye surgery in the last 3 months. Any abnormality that prevents reliably flattening tonometry. Any other condition including serious illness that would make the patient, in the Investigator&apos;s opinion, unsuitable for the study. Therapy with another investigating agent within 30 days prior to the Screening Visit. Use of any additional topical or systemic ocular hypotensive medication during the study. Concomitant use of glucocorticoids given by any route.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-95n4vs	Clinical simulation and effects on nursing students	Recruitment completed	Intervention	2019-12-27	<NULL>	<NULL>	3309	Clinical simulation of cardiorespiratory and cerebral arrest in adults: evaluation with undergraduate nursing students	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade da integração Internacional da Lusofonia AfroBrasileira	Universidade da integração Internacional da Lusofonia AfroBrasileira	https://ensaiosclinicos.gov.br/rg/RBR-95n4vs	<NULL>	Student regularly enrolled in the seventh and ninth undergraduate who have attended and passed the Adult Health discipline.	Previous Emergency Experience	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-7vkm58y	Clinical Simulation as a teaching methodology on Patient Safety	Recruitment completed	Intervention	2022-09-08	<NULL>	<NULL>	5600	Effectiveness of Clinical Simulation as a teaching tool- learning about Patient Safety: an Experimental Study	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Patrícia Freire de Vasconcelos	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-7vkm58y	<NULL>	Be a student regularly enrolled in the Undergraduate Nursing Course at Universidade Internacional da Lusofonia Afro-Brasileira; Be studying between the 6th and 8th semester.	Not having attended the subjects of Care Process in Adult Health or Surgical Center and Sterilization Material; Failure to participate in any of the procedures established in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-4r8cb9	Clinical simulation for teaching of sexuality of individuals with spinal cord injuries	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3661	Clinical simulation for teaching of sexuality of patients with spinal cord injuries	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-29	Faculdade de Enfermagem da Universidade Estadual de Campinas	Faculdade de Enfermagem da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4r8cb9	<NULL>	"Students regularly registered in undergraduate nursing courses who attended or are attending
semiology and semiotechnics / fundamentals and some discipline that contemplates the content of
Women&apos;s Health."	Students who are absent from any stage of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-4nm87k2	Clinical Simulation for training health professionals in assistance in the first hour of labor and birth	Not yet recruiting	Intervention	2024-02-21	<NULL>	<NULL>	7227	Effectiveness of Clinical Simulation for training health professionals in assistance in the first hour of labor and birth: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Faculdade de Enfermagem da Universidade Federal de Goiás	Secretaria da Saúde do Estado de Goiás - Leide das Neves Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-4nm87k2	<NULL>	Health professionals in the obstetric area working in direct assistance to parturient and postpartum women and newborns in the following sectors: Obstetric Emergency, Surgical Center, Normal Delivery Unit and Joint Accommodations; be contactable by telephone; have access to the internet at home or on your cell phone; both genders	Health professionals who, during the period of data collection, are on vacation, or on sick leave, or away from care or serving prior notice; professionals who, after three attempts, are not on their original shift according to the duty schedule; professionals who have already participated in a Clinical Simulation course for Postpartum Hemorrhage (PPH)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-2g5yx5	Clinical simulation in teaching to undergraduate nursing in wound assessment	Recruitment completed	Intervention	2018-05-25	<NULL>	<NULL>	1851	Clinical simulation in teaching-learning process to undergraduate nursing in wound assessment: randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Estadual de Campinas	Faculdade de Enfermagem da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2g5yx5	<NULL>	Second year undergraduate nursing students	Exchange students who have had experience with a course or training in wounds using clinical simulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-6hk9vgs	Clinical Simulation Scenario for the acquisition of competence in the management of Postpartum Hemorrhage	Recruitment completed	Intervention	2023-04-18	<NULL>	<NULL>	6019	Effectiveness of a Clinical Simulation Scenario for acquiring competence in the management of Postpartum Hemorrhage: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Maternidade Escola Assis Chateaubriand-MEAC	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6hk9vgs	<NULL>	Being a nurse working in the care of parturients and/or puerperal women in the different sectors of the emergency institution, obstetric center, surgical center, post-anesthesia recovery room, puerperium, maternal ICU	Nurse who has a compromised physical or mental state of health (self-reported), in such a way as to make the clinical simulation unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-6gjm5gr	Clinical study comparing a nasal spray and a nasal saline solution in continuous jet in the prevention of the new coronavirus (COVID-19)	Not yet recruiting	Intervention	2021-07-27	<NULL>	<NULL>	4798	Non-inferiority, prospective, phase III, single-center, open, randomized, parallel-group clinical study comparing Carrageenan nasal spray and 0.9% sodium chloride nasal saline in a continuous stream in the prevention of COVID-19	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-08-02	Herbarium Laboratório Botânico	Herbarium Laboratório Botânico	https://ensaiosclinicos.gov.br/rg/RBR-6gjm5gr	<NULL>	Healthy men and women aged between 18 and 60 years; be asymptomatic and present oximetry &gt; 94%, at rest; being a contact and living in the same household as a patient with positive clinical and laboratory diagnosis for coronavirus (SARS-CoV-2), with up to 7 days of clinical manifestations, seen in the emergency department of Hospital Mater Dei; no signs and symptoms of coronavirus-related illnesses (SARS-CoV-2), influenza, or cold in the past 6 months; agree with the study procedures and sign the consent form.	Participants with a history of positive diagnosis for coronavirus (SARS-CoV-2) in the last 6 months; participants already immunized with any type of vaccine for the coronavirus (SARS-CoV-2), even if they received only the first dose; diagnosis of poorly controlled rhinitis or respiratory allergy and/or in crisis, whether acute or chronic; chronic lung diseases in the process of aggravation or in crisis; chronic or obstructive clinical manifestations of the nose: septal deviation, nasal polyposis, chronic sinusitis; recurrent sinusitis (&gt; 3 episodes) in the last 6 months; treatment with antibiotics, systemic or inhaled steroids in the last 4 weeks; breastfeeding and/or pregnancy; coagulation disorders; known or suspected hypersensitivity to the formula of the products under study; severe or decompensated cardiovascular disease, decompensated diabetes mellitus, kidney or liver dysfunction, malignancy or suspected malignancy; any other criteria or clinical history that could compromise the participant&apos;s well-being or interfere with the research results, in the researcher&apos;s opinion (example: chronic diseases).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-5v9wmqg	Clinical study comparing Non-surgical Periodontal Therapy with and without association with Antimicrobial Photodynamic Therapy (aPDT- laser light) for Periodontitis	Recruitment completed	Intervention	2024-10-31	<NULL>	<NULL>	7469	Randomized clinical trial comparing Non-surgical  Periodontal Therapy with and without association with Antimicrobial Photodynamic Therapy (aPDT) in the treatment of Periodontitis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-09	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5v9wmqg	<NULL>	Individuals with periodontitis; over 35 years of age; of both genders and with 10 or more teeth present in the mouth	Patients with type 1 and type 2 diabetes; chronic kidney disease; malignant neoplasms; Acquired Immune Deficiency Syndrome, autoimmune diseases; be pregnant or breastfeeding; being immunosuppressed by medication; have evidence of other ASA III and IV systemic diseases; have changes in menstrual flow; be smokers or ex-smokers for less than twenty years; being users of orthodontic appliances; have a history of using steroidal or non-steroidal anti-inflammatory drugs in the previous three months and during the study; use of antibiotics in the last 4 months; use of any dietary supplements including antioxidant supplements in the last six months before the study; following any specific diet in addition to their usual diets during the last six months and having received supra and subgingival scaling and or periodontal surgery in the six months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-4gnm8n	Clinical study comparing palonosetron with ondansetron for prevention of nausea and vomiting after uterus surgery under spinal anesthesia with morphine	Recruitment completed	Intervention	2015-11-10	<NULL>	<NULL>	650	Randomized clinical trial comparing palonosetron with ondansetron for prophylaxis of nausea and vomiting after abdominal hysterectomy under spinal anesthesia with morphine	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-01-22	Hospital São Rafael	Hospital São Rafael	https://ensaiosclinicos.gov.br/rg/RBR-4gnm8n	<NULL>	One hundred and thirty patients classified as American Society of Anesthesiologists (ASA) physical status 1 or 2; aged between 18 and 65 years.	Patients who received corticosteroids and antiemetic drugs in the 24 hours before the procedure; ASA physical status III or IV; allergy to medications involved in protocol; situations that contraindicate to perform spinal anesthesia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-5jf2whs	Clinical study evaluating the efficacy and safety of Platelet-Rich Plasma combined with topical Minoxidil compared with placebo also combined with topical Minoxidil in men with Androgenetic Alopecia	Recruitment completed	Intervention	2025-12-01	<NULL>	<NULL>	8607	A randomized placebo controlled, double-blind, half-head study to assess the efficacy and safety of Platelet-Rich Plasma on the treatment of Androgenetic Alopecia	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-10	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Participants aged 18 to 65 years. Male gender. With Androgenetic Alopecia (AGA). Normal serum levels of Thyroid-Stimulating Hormone (TSH), Free Thyroxine (Free T4), Iron, Ferritin, Transferrin Saturation, and Complete Blood Count to rule out telogen effluvium. Agreement with the study conditions. Ability to understand and strictly follow the given instructions. Availability to attend periodic follow-up evaluations. Signing of the Informed Consent Form (ICF) and the Photography Authorization Form	Use of topical Minoxidil; oral Minoxidil, or oral Finasteride in the last three months. Performance of any cosmetic procedures on the scalp in the last six months (e.g., microneedling, intradermal drug infusion). Hematologic coagulation disorders, anticoagulant therapy, use of antiplatelet agents, thyroid deficiency, dermatologic disorders, or systemic diseases that contribute to hair loss. Unrealistic expectations. Severe systemic diseases or use of systemic corticosteroids or immunosuppressants. Scalp diseases presenting the Koebner phenomenon. Allergy to tattoo dye. Allergy to Lidocaine	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-89rd4p	Clinical study for the evaluation of different local anesthetic dental techniques	Recruiting	Intervention	2018-12-11	<NULL>	<NULL>	2379	Comparison of pain perception using conventional and computerized anesthetic techniques: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-89rd4p	<NULL>	Patients should be at least 18 years of age with chronic periodontal disease, presenting at least one vital tooth with a clinical depth of probing greater than or equal to 4 mm in at least one of the probed sites in three different hemiarcates.	Patients in periodontal maintenance; sensitivity or any form of allergic reaction to amide-based anesthetics; have used analgesic or anesthetic medication for at least 12 hours prior to the periodontal instrumentation procedure; patients with previous history of alcoholism; pregnant or lactating women; patients with severe uncontrolled systemic disease such as heart, neurological, renal, hepatic or blood problems; psychiatric problems that could interfere with the scaling and smoothing or administration of topical anesthetics and injectables. Local pathological changes such as presence of ulcerative lesions, abscesses, acute infections; need for exodontia in the study quadrant; dentin hypersensitivity; absence of vitality or other pulp pathologies that could interfere in the measurement of the data in the teeth involved in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-88jp3fg	Clinical study for the treatment of Halitosis	Recruitment completed	Intervention	2025-11-12	<NULL>	<NULL>	8518	Efficacy in the treatment of Halitosis: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade Meridional	<NULL>	<NULL>	<NULL>	Volunteers with halitosis confirmed by organoleptic evaluation and positive self-perception of halitosis, aged 18 years or older.	Volunteers with uncontrolled diabetes, liver disorders, recurrent oropharyngeal infections, flu-like symptoms, use of dental prostheses, recent oral surgical procedures, and penicillin and metronidazole medications were excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:39
RBR-67cjv5	Clinical study in the treatment of menstrual cramps	Recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2069	Randomized clinical trial in the treatment of primary dysmenorrhoea syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-11	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-67cjv5	<NULL>	Accept signing the free and informed consent form; age between eighteen and thirty-five years; pelvic pain caused by primary dysmenorrhea; first to the third day of the menstrual cycle; between one and ten on the analogue visual pain scale	Age less than eighteen and over thirty-five years; patients taking analgesics and other therapies for pelvic pain; gynecological pathologies; undiagnosed abdominal pain; patients with cardiac pacing; cardiac complications; degree 0 on the visual analogue pain scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-6jmr68m	Clinical study of a Type of Vitamin E obtained from the annatto in the control of High Cholesterol	Recruitment completed	Intervention	2023-06-28	<NULL>	<NULL>	6183	Clinical study of a Formulation Containing 70% Tocotrienol, obtained from annatto, in the control of Lipidemias	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-15	Hospital das Clínicas da Universidade Estadual de Campinas	New Max Industrial Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-6jmr68m	<NULL>	People aged from 18 years to 75 years; both sexes; with dyslipidemia, characterized by serum levels of Low Density Lipoprotein above 100mg/dL and who are not allergic to annatto or traces of annatto	People with psychiatric disease or other disease that affects the understanding of the consent term; Women who are pregnant or breastfeeding; People with allergy to Urucum; People to whom specific drug is being administered to control high levels of triglycerides; people with comorbidities, including diabetes, cardiovascular disease,  several renal failure, hepatitis;active infeccion  and participants who make a change in lifestyle that impacts the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-4dct89b	Clinical Study of Bone Grafting in Dentistry	Recruiting	Intervention	2022-04-18	<NULL>	<NULL>	8051	Randomized Prospective Longitudinal Study of Calcium Phosphate Biphasic Graft	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Santa Catarina	Dentscare - LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4dct89b	<NULL>	Patients who have indications for bone grafting in maxillary sinus lift, socket filling after tooth extraction and filling the gap after implantation immediately after tooth extraction, compatible with indications for the use of bone graft biomaterials; patients over 12 years old; both genders	Patients under 12 years old; patients with infected areas and acute inflammatory processes; Pregnant or breastfeeding patients; patients with endocrine diseases or uncompensated chronic diseases such as diabetes, autoimmune dysfunction, therapy; or using drugs that compromise the healing response of bone tissue como prolonged therapy with corticosteroids, chemotherapy, bisphosphonates	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-62v9htw	Clinical study of children health	Recruiting	Intervention	2024-05-02	<NULL>	<NULL>	6986	Impact of the Herbst appliance in the management of Obstructive Sleep Apnea in patients with class II, division 1 malocclusion: randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo (FOB-USP)	Faculdade de Odontologia de Bauru - Universidade de São Paulo (FOB-USP)	https://ensaiosclinicos.gov.br/rg/RBR-62v9htw	<NULL>	Individuals aged between 9 and 14 years; both genders; in stages of cervical maturation Cervical Stage 2 or 3 according to the Cervical Vertebrae Maturation method, carriers of Class II division 1 malocclusion (skeletal parameter: ANB &gt; 4); dental parameter: minimum severity of ½ Angle Class II) and diagnosed with Obstructive Sleep Apnea (OSA), screened by the validated Brazilian version of the Pediatric Sleep Questionnaire and confirmed by polysomnography (PSG)	Hyperdivergent individuals; those with craniofacial syndromes and anomalies; individuals who have undergone previous orthodontic treatments with headgear, jaw breakers, any type of functional orthopedic appliance and fixed appliances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-5pdp82	Clinical study of different dental ceramics for partial restorations	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4298	Milled Feldspathic and Lithium Disilicate Onlays with a 2-Year Follow-Up: Split-Mouth Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-02	Universidade Estadual Paulista - Instituto de Ciência e Tecnologia	Universidade Estadual Paulista - Instituto de Ciência e Tecnologia	https://ensaiosclinicos.gov.br/rg/RBR-5pdp82	<NULL>	Presence of caries injury; defective amalgam or composite resin restorations in the posterior dentition; suitable for restoration with ceramic onlays; presence of antagonistic tooth; over 18 years; good general and oral health; absence of orthodontic appliances; absence of malocclusion and dental malformation; absence of non-carious cervical lesions; vital posterior teeth and proven periodontal health.	Absence of caries lesion; suitable old restorations; little coronary destruction; absence of antagonistic tooth; less than 18 years; uncontrolled systemic impairment; orthodontic appliance users; presence of malocclusion and dental malformation; presence of non-carious cervical lesions; posterior teeth treated endodontically and periodontal health compromised.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-4ttb63q	Clinical study of nuclear alterations in patients undergoing in-office tooth whitening	Data analysis completed	Intervention	2024-05-24	<NULL>	<NULL>	7022	Evaluation of the genotoxic potential of dental whitening in patients with different age groups: clinical study	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade de Odontologia - Universidade Federal do Amazonas	Faculdade de Odontologia - Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4ttb63q	<NULL>	Both sexes; age between 14 and 18 years old and 31 and 50 years old; no systemic diseases (metabolic, immunological and heart diseases); with oral condition free from carious lesions or periodontal diseases; central incisor or canine color A2 or darker; six upper anterior teeth free of restorations on the buccal surface; healthy enamel; dissatisfaction with the color of your teeth; no pathological changes; physiological and medicinal	Dentin hypersensitivity; smoker; alcoholic; pregnant or breastfeeding; orthodontic appliance; severe crowding, presence of intrinsic spots and ages between 19 and 30 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-4ccdqh6	Clinical study of Removable Partial Dentures constructed with different structural materials	Recruitment completed	Intervention	2023-07-31	<NULL>	<NULL>	6294	Removable Partial Dentures with Co-Cr versus PEEK structure: clinical crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Faculdade de Odontologia de Piracicaba - FOP/UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-4ccdqh6	<NULL>	Present good general health status or presence of systemic diseases (such as hypertension and/or diabetes) that are properly controlled; age between 40-65 years; total upper and lower partial edentulousness (Kennedy Class I), with unsatisfactory CDs and RPDs according to Vigild&apos;s criteria (Vigild et al., 1987); having the shape of the lower alveolar ridges classified as horizontal or distal ascending (in the mesiodistal direction), and normal or high (in the buccolingual direction), according to the American College of Prosthodontics (McGarry et al. 1999), evaluated by means of the clinical examination and normal salivary flow (≥ 0.6 ml/min)	Individuals with painful symptomatology of the temporomandibular joints and/or mastication muscles; uncontrolled systemics diseases; xerostomia patients; severe periodontal disease and/or tooth mobility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-2mfbkkk	Clinical study of the application of Light Therapy in the treatment of Taste Disorders in post-COVID-19 patients	Not yet recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5262	Clinical study of the application of Photobiomodulation in treatment of Dysgeusia in post-COVID-19 patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2mfbkkk	<NULL>	Tested positive for coronavirus (COVID-19) after the Reverse Transcriptase Reaction followed by Polymerase Chain Reaction (RT-PCR) examination and who complained of symptoms of dysgeusia; Patients aged 18 years or older; Patients who are not in the disease transmission phase (fifteen days after the onset of symptoms); Patients who accept to be part of the research by signing the Free and Informed Consent Term; Patients who underwent gustatory dysfunction assessment tests and dysgeusia was confirmed	Patients who tested negative for coronavirus (COVID-19) after the Reverse Transcriptase Reaction followed by Polymerase Chain Reaction (RT-PCR) test; No complaints of dysgeusia symptoms; Under 18 years old; Pregnant and/or lactating patients; Patients who do not accept to participate in the research or who do not sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-8ppyzb2	Clinical study of the combination of paracetamol, phenylephrine and chlorpheniramine in the treatment of flu and common cold.	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8531	Efficacy and safety study of the combination of paracetamol, phenylephrine and chlorpheniramine in the symptomatic treatment of flu and common cold.	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Scentryphar Pesquisa Clínica Ltda	<NULL>	<NULL>	<NULL>	Patients capable of understanding the nature of the study, willing to comply with all study procedures, and who agree to provide signed informed consent; Male or female, aged greater than or equal to 18 years and less than or equal to 65 years at the time of signing the informed consent; Patients must have a cold or flu-like illness diagnosed by a healthcare professional at the study center, with the following symptoms having started within 72 hours before the screening/baseline visit: nasal congestion, sneezing, and runny nose. The severity of general nasal symptoms must be at least moderate on a five-point Likert-type symptom severity scale (0 = no symptoms; 1 = mild; 2 = moderate; 3 = severe; 4 = very severe); Patients must also have non-nasal cold symptoms (sore throat, headache, cough, myalgia, and fever). The severity of pain symptoms must be at least moderate on a five-point Likert-type symptom severity scale (0 = no symptoms; 1 = mild; 2 = moderate; 3 = severe; 4 = very severe); Patients must have a sum of physician assessment of signs scores of at least 5	Pregnant or breastfeeding women (lactating women); Women who do not agree to use temporary contraceptive methods; Men who do not agree to use temporary contraceptive methods (considering the short treatment time of this study), such as barrier methods, during the study, except for those who are surgically sterile (vasectomy), or who have female partners who use effective contraceptive methods, or surgically sterile partners, or partners who have been menopausal for at least 1 (one) year, or participants who declare that they do not engage in sexual practices or engage in them in a non-reproductive manner; History of or known hypersensitivity to any of the study medications, excipients, or medications of similar chemical classes; Rapid onset of symptoms that, in the investigator&apos;s opinion, are indicative of severe cases of influenza; Use of alcohol or illicit drugs; Use of monoamine oxidase (MAO) inhibitors or barbiturates; Perennial or seasonal allergic rhinitis confirmed at screening; History of or chronic respiratory disease (within the past 5 years); Presence of nasal polyps, significant nasal septum deviation, or any other anatomical abnormality affecting airflow; Any current acute illness or uncontrolled exacerbation of a chronic disease; Any evidence (within 2 years) of significant cardiovascular, pulmonary, renal, hepatic, gastrointestinal, hematologic, endocrinologic, metabolic, neurologic, psychiatric, or other disease at screening, including hypertension, cardiac arrhythmias, serious organic changes of the heart and blood vessels, uncontrolled thyroid disease, thyrotoxicosis, decompensated diabetes, or benign prostatic hypertrophy, based on the investigators&apos; assessment; Long QT syndrome or QTc greater than 450 msec for men and greater than 470 msec for women at screening/baseline; Clinical evidence of immunosuppression; Clinically relevant chronic or acute infectious diseases or febrile infections within 2 weeks prior to study entry, including bacterial sinusitis within 2 weeks prior to the screening visit/baseline period; Influenza vaccination up to 1 week prior to enrollment; Need for antiviral therapy to treat influenza A or B infection; Need for antibacterial therapy to treat acute respiratory infection; Use of medication to treat conditions acquired prior to enrollment for a period shorter than two time intervals of administration of these medications; Patients using medications likely to interact with phenylephrine and chlorpheniramine (alcohol, opioid analgesics, anticonvulsants, antidepressants (tricyclic monoamine oxidase inhibitors), antihistamines, antiemetics, antipsychotics, anxiolytics and hypnotics, alpha and beta blockers, vasodilators, sympathomimetic agents) and paracetamol (for paracetamol alone: ​​within 24 hours before study drug intake and during the study, also anticoagulants such as warfarin and coumarin, chloramphenicol, probenecid, rifampicin and isoniazid, cholestyramine, metoclopramide, domperidone, zidovudine, didanosine, propantheline) should be excluded; Use of another investigational drug in the period less than one year before enrollment; Any other changes in laboratory tests regarding complete blood count, blood glucose (pre- or postprandial), sodium, potassium, creatinine, total bilirubin, AST, AST, alkaline phosphatase, and γ-GT, which, in the investigator&apos;s discretion, are considered clinically significant; Patient reports consumption of any drug-metabolizing enzyme (e.g., CYP3A4 or other cytochrome P450 enzymes) inducing or inhibiting foods, beverages, or dietary supplements (e.g., broccoli, Brussels sprouts, grapefruit, grapefruit juice, star fruit, St. John&apos;s wort, etc.) within 48 hours prior to the first scheduled administration of the study drug, or is expected to consume such products during the period or at any time throughout the study; Surgery of the gastrointestinal tract that may interfere with drug absorption (note: this is not applicable to minor abdominal surgery without significant tissue resection, e.g., appendectomy or herniorrhaphy)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:52
RBR-5n4q8b	Clinical study of the influence of surface treatment on dentin before dental restorations near the gingiva	Recruitment completed	Intervention	2020-03-23	<NULL>	<NULL>	3642	Randomized, triple-blind clinical study of the influence of surface treatment on adhesion of noncarious cervical lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-03	Cristiane de Melo Alencar	Cristiane de Melo Alencar	https://ensaiosclinicos.gov.br/rg/RBR-5n4q8b	<NULL>	Acceptable oral hygiene; present at least 20 teeth under occlusion; present at least two non-carious cervical lesions to be restored in two different teeth; non-carious lesions deeper than 1 mm.	Participants with a compromised medical history; periodontal disease; severe or active carious disease; use of orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-9wkw73j	Clinical study of the use of Bevacizumab in glaucoma surgery.	Recruiting	Intervention	2021-05-30	<NULL>	<NULL>	4702	"Randomized clinical study of the use of intravitreal injection of Bevacizumab in
primary open-angle glaucoma."	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-10	União Metropolitana de Educação e Cultura	União Metropolitana de Educação e Cultura	https://ensaiosclinicos.gov.br/rg/RBR-9wkw73j	<NULL>	The inclusion criteria will be:  Primary Open Angle patients over 40 years of age, with uncontrolled Intraocular pressure (IOP) on maximum tolerated medical therapy, requiring trabeculectomy. Indications for trabeculectomy will include eyes where IOP measurements associated with a high probability of glaucoma progression or eyes where a deterioration of the visual field or the optic disk compatible with progressive glaucomatous damage was documented by the examining physician.	Patients will be excluded if known to have an allergic reaction either to MMC or BZM, had undergone previous intraocular surgery (except uneventful cataract surgery); were diagnosed with normal tension glaucoma, angle closure glaucoma or secondary glaucomas; had prior history of ocular infection, uveitis or ocular trauma; were pregnant or breast-feeding women; had a history of uncontrolled diabetes and/or systemic hypertension or any other systemic condition that could be influenced by BZM injections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:34
RBR-6gs4bdh	Clinical study of the use of electrical stimulation on leg circulation and coagulation	Data analysis completed	Intervention	2024-01-29	<NULL>	<NULL>	6754	Study of the application of neuromuscular electrical stimulation on lower limb hemodynamics and systemic fibrinolytic activity	<NULL>	2-3, single-arm-study, single-blind	2-3	<NULL>	<NULL>	<NULL>	2019-11-06	Departamento de Cirurgia e Ortopedia da Faculdade de Medicina de Botucatu	Departamento de Cirurgia e Ortopedia da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6gs4bdh	<NULL>	Being between 18 and 40 years old. Both genders. Sign the Free and Informed Consent Form.  Have a Body Mass Index (BMI) between 18 and 34 kg/m2	Use of illicit drugs in the last 12 months. Use of the following medications in the last 24 hours: medicines for headache with vascular effect, such as sumatriptan, ergot derivatives, isomeptene, etc, analgesics such as dipyrone and paracetamol, non-steroidal anti-inflammatory drugs such as ibuprofen, naproxen, diclofenac, etc.  Consumption of foods in the last 24 hours with a known effect on vascular reactivity, according to the list: coffee, folic acid, vitamin C, high doses of fish oil, vitamin supplements, fruits and vegetables in large quantities such as cranberries (also known as cranberries) and grapefruit (also known as grapefruit), beets and black currants, wine, tea, cocoa and derivatives, chocolate and hazelnuts, natural grape and orange juice, cheese, probiotics (foods with this effect), capsaicin, like pepper, energy drinks, beer. Any significant illness within the last 4 weeks of exposure. Pregnancy or lactation. Use of hormonal contraceptive method, including IUD etc., in the last 3 months. Active smoker or ex-smoker in the last 12 months. History of peripheral arterial obstructive disease. Ankle-brachial index less than 0.9, defined in anamnesis and physical examination. History of chronic venous insufficiency in the lower limbs. Ulcer on lower limbs. History of venous thromboembolism. History of fracture or presence of metallic implants in lower limbs. Have an infection at the electrode implantation site. Have participated in a drug or medical device study up to 4 weeks previously. Use of any neuro-modulating device. Surgery 3 months before the study (such as abdominal, gynecological, etc.). Trauma to the lower limbs that may prevent correct electrical stimulation of the common peroneal nerve. Use of a pacemaker or implantable cardioverter-defibrillator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-4x9pk3m	Clinical study of Toothpaste with bioactives from the sap of the Amazonian dragon&apos;s blood tree (Croton lechleri) and Activated charcoal: sensory properties and effects on Bacterial plaque and Gingival health	Recruitment completed	Intervention	2024-12-20	<NULL>	<NULL>	7618	Clinical study of Toothpaste with Dragon´s blood (Croton lechleri) and Actived charcoal: organoleptic properties and effects on Dental biofilm and Gingival health	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-04-03	Universidade Estadual Vale do Acaraú	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4x9pk3m	<NULL>	Spontaneous demand; screening between April 2023 and April 2024; adults between 18 and 40 years old; both sexes; all ethnicities; without compromising systemic health; no smoking or alcohol consumption; dentition with more than 24 teeth; no ongoing orthodontic treatment; no daily use of mouthwashes; no use of mouthwashes and/or toothpastes with chlorhexidine in the last 60 days	Failure to sign the informed consent form (ICF); dropping out of the study; inappropriate use of the products to be tested; motor incoordination that makes tooth brushing difficult; surgery on the face or mouth that makes tooth brushing difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-29fjs5r	Clinical study of two biomaterials used to control bleeding after extraction of mandibular third molars	Data analysis completed	Intervention	2025-08-18	<NULL>	<NULL>	8213	Randomized clinical study of two hemostatic agents in dental socket of mandibular third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Programa de Pós-Graduação em odontologia da Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-29fjs5r	<NULL>	The physical criteria included research participants with bilateral third molars indicated for extraction; aged between 18 and 40 at the time of recruitment; both genders; the psychological criteria for participation in the project comprised patients with no history of anxiety; mood; eating; or psychotic disorders that could compromise their participation and collaboration in the study; these were evaluated by completing an anamnesis form	All research participants who smoked; were dependent on alcohol; had systemic diseases (eg, diabetes, blood dyscrasias) were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-93x9vcb	Clinical study of two root filling materials in treating a vital pulp of deciduous tooth	Data analysis completed	Intervention	2022-11-03	<NULL>	<NULL>	5699	Double-blind randomized clinical trial of the performance of two root filling materials in biopulpectmies of primay molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-04	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-93x9vcb	<NULL>	First or second deciduous lower molar with deep caries and pulp vitality; provoked or spontaneous pain that does not relieve with the use of medication; in case of teeth with provoked pain, absence of hemostasis in adequate time up to 5 minutes, after attempted pulpotomy; absence of fistula or abscess; absence of bone rarefaction on radiographic examination; absence of internal or external resorption of more than two thirds of the root; tooth restorative possibility	Children with difficult behavior and who do not cooperate with the treatment; children who have systemic health problems; teeth with periapical lesion or interradicular bone rarefaction; internal and or external resorption involving more than one thirds of the root length; teeth with less than two thirds of the root remainder; rupture of the pericoronary sac; restorative impossibility; teeth that have had some kind of previous pulp treatment; patients using antibiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-9rwqr3	Clinical study on gingival inflammation in teeth restored with ceramic veneers with and without finish line. Evaluation by clinical parameters and by bacteria and inflammatory mediators present in the gingival crevicular fluid.	Not yet recruiting	Intervention	2020-03-27	<NULL>	<NULL>	3672	Influence of ceramic veneers cemented over teeth with and without finish line on the inflammatory mediators and microbiota of gingival crevicular fluid. Clinical, controlled, randomized, blind, prospective and longitudinal study using ELISA and RT-PCR	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-9rwqr3	<NULL>	Patients who require ceramic veneers restorations in the region between teeth 15 to 25; healthy teeth and in good periodontal health; the need to close diastemas; eliminate dead spaces; correct shape and dental contour with aesthetic and / or functional justification attested by diagnostic waxing.	Periodontal disease active; loss of insertion; probing depth greater than 3 mm; bleeding on probing in more than 10% of the evaluated sites; radiographic bone loss; pregnancy, diabetes mellitus; autoimmune diseases and other uncontrolled systemic changes with a detrimental effect on periodontal tissues; users of controlled drugs; presence of hormonal or vitamin deficiency; history of recent use (less than 3 months) of anti-inflammatories or antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-99msdj3	Clinical study on the accuracy of techniques for measuring canals in baby teeth	Recruiting	Intervention	2025-09-03	<NULL>	<NULL>	8252	Evaluation of accuracy in Odontometry in deciduous teeth: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-99msdj3	<NULL>	Patients of both genders seeking dental treatment at the Pediatric Dentistry Clinic Bauru School of Dentistry, University of São Paulo (FOB-USP); aged between 3 and 9 years;authorized by their guardians through the signing of the Free and Informed Consent Form (FICF), and presenting at least one deciduous tooth with clinical and radiographic characteristics indicating and enabling the performance of pulpectomy. This allows for the treatment of various canals with different forms of physiological resorption typical of primary dentition, facilitating a comprehensive analysis of the accuracy of the locators. Clinically, the presence of painful symptoms; fistulas, or abscesses will be observed, along with the feasibility of performing absolute isolation and subsequent tooth restoration. Radiographically, the presence of rarefaction will be analyzed as an indicator of irreversible pulp involvement.	Children with any type of systemic health condition; teeth with previous endodontic treatment; teeth where isolation or subsequent restoration is not feasible; teeth with pulp calcification; or teeth with pathological internal or external resorptions that prevent the instrumentation of root canals.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-5v6g7f	Clinical study on the application of a Gel to reduce Pain in Teeth after realizing In-Office Bleaching	Recruitment completed	Intervention	2018-06-25	<NULL>	<NULL>	2283	"Comparison between the application of a Gel to reduce Dental Pain resulting from
Bleaching, before the Gel and before / after the Gel. A clinical study in patients"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5v6g7f	<NULL>	Candidates must have all teeth from canine to upper and lower canine without caries manifestations; restorations; exposed dentin and spontaneous dentin sensitivity. Can sign a free and informed consent form. Have between 18 and 40 years. Commit to attend for periodic examinations.  Have good oral and general health. Canines with color A2 or darker compared to the color scale.	Patients who have previously performed the bleaching procedure. Pregnant or nursing. Patients with tetracycline staining (grade I, II, III or IV); fluorosis or endodontic treatment in the anterior teeth. Patients with bruxism and severe periodontitis. Continuous use of some medicine with anti-inflammatory or antioxidant action. Patients who present and / or report spontaneous dental sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-838r987	Clinical study on the effect of a device that emits light on the success of venipuncture in children	Recruiting	Intervention	2021-02-23	<NULL>	<NULL>	4556	Clinical, randomic and controlled study on the effect of transilumination on the success of peripheral intravenous catheterization in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-838r987	<NULL>	Age between 29 days of life and 12 incomplete years; CIP performed on a day shift; Elective CIP indication with catheter over needle; Stable clinical or surgical conditions; First peripheral intravenous catheterization performed in the studied hospital units	Children and / or family members who give up on participating in the research, after their inclusion; Children with more than 4 attempts at peripheral intravenous catheterization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-7v7tj5	Clinical Study on the effect of Bleaching Toothpastes	Data analysis completed	Intervention	2018-09-17	<NULL>	<NULL>	2202	Clinical Trial on the effectiveness of Bleaching Toothpastes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7v7tj5	<NULL>	Both genders; older than 18 years; presence of all natural anterior superior teeth; vitalized; naturally or physiologically darkened; without restorations involving the vestibular faces; with color darker or equal to A3 in the VITA scale of the tint guide; good oral health.	Patients with dental sensitivity; cervical lesions or fractures; smokers; pregnant women and infants; children and adolescents (under 18 years of age); previous history of cancerous lesions; caries and periodontal disease; prosthetics and / or previous restorations were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-29mvy54	Clinical study on the effect of Microfocused Ultrasound on facial rejuvenation	Not yet recruiting	Intervention	2025-02-13	<NULL>	<NULL>	7745	Clinical study on the efficacy and safety of Microfocused Ultrasound for Facial Rejuvenation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-02	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-29mvy54	<NULL>	Patients aged between 35 and 65 years; patients who show moderate signs of skin aging; both sexes	Patients with a history of photosensitivity will be excluded; tendency to form keloids; with dermatitis; active herpes infection at the procedure site; pregnant women; breastfeeding women; pacemaker holders; with decompensated chronic diseases; wearing metal prostheses in the area to be treated; with a history of heart disease; patients with a history of autoimmune diseases using isotretinoin; anticoagulants; with a history of previous aesthetic treatments in the area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-2j26pk	Clinical Study to Assess Anticellulite Efficacy	Not yet recruiting	Observational	2020-04-22	<NULL>	<NULL>	3765	"Clinical Study for Dermatological Evaluation of
Anti-cellulite Acceptability and Effectiveness"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Malwee Malhas Ltda,	Malwee Malhas Ltda,	https://ensaiosclinicos.gov.br/rg/RBR-2j26pk	<NULL>	"Age from 18 to 45 years; Women; Healthy participants (evaluated by the dermatologist); Phototypes I to IV (according to the Fitzpatrick classification), due to the study of acceptability and the
possibility of quickly detecting skin reactions with this scale; Presence of cellulite in the experimental region (buttocks and thighs); Presence of grade I, II, III and IV cellulite; Participants who accept not to change the normal daily routine of their cosmetic habits, except for the use of topical products with activity similar to the test product during the entire study, these do not
must be used; The Informed Consent Form (ICF) has been clarified and signed; Participants who want to participate in the study without financial profit. They will be reimbursed for expenses related to the test, such as transportation and food, among others; Participants who have not participated in similar studies for at least 2 months prior
to study; Regular / occasional users of cosmetic products similar to the product under investigation; Participants who declared they were not at risk of pregnancy during the survey period"	"Allergy to the tested product category; Pregnancy or lactation; Immunodeficiencies; Active atopic dermatitis; Kidney, heart or liver transplantation; Use of the following medications: corticosteroids, antihistamines, immunosuppressants, retinoids, anti-inflammatories; Any condition that may interfere with the evaluations according to the Investigator of the study; Participants who refuse to participate in the study in question.
Note: the participants included are instructed not to change their diet, cosmetic and hygiene habits, exercise routine and contraceptive method. Also, not to use products of the same product category
tested in the experimental region"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-65trt53	Clinical study to assess safety and efficacy related to the use of donor stem cells in the treatment of COVID-19.	Other	Intervention	2020-12-14	<NULL>	<NULL>	4418	"Double-blind, randomized, placebo-controlled study to assess
Safety and Effectiveness of Protection Against SARS-Cov-2 Infection: Infusion of
Mesenchymal Stem Cells (MSCs) from expanded deciduous tooth pulps,
As Allogeneic Therapeutic Strategy."	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2021-04-30	R-Crio Criogenia S.A.	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-65trt53	<NULL>	Man or woman; aged 60 years or over; with laboratory confirmation of the infection (COVID-19) by polymerase chain reaction with reverse transcription (RT-PCR); presence of at least one risk factor (co-morbidity) beyond age; adequate and healthy hematological values; hemoglobin 100 g / L, neutrophils 1.0 x 10 (9) / L, platelets 150 x 10 (9) / L; adequate livre function; ALT and AST 2.5 x ULN, bilirubin 1.5 x ULN;Adequate renal function; calculated creatinine clearance 50 mL / min; written informed consent signed by the candidate.	Patients with severe allergies; serious basic illnesses that affect survival, including blood disorders, cachexia, active bleeding, severe malnutrition; obstructive pulmonary pneumonia, severe pulmonary interstitial fibrosis, alveolar proteinosis, allergic alveolitis and other known viral pneumonia or bacterial pneumonia; continuous use of immunosuppressive agents or organ transplants in the last 6 months; cancer being treated or even treated (a formal opinion from the responsible doctor is required); low adherence and unable to complete the full study; increased risk of the subject or other conditions that interfere with the clinical trial and the judgment of results such as excessive stress, sensitivity or cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:10
RBR-6jn3xr9	Clinical study to assess the effectiveness of the combination of Laser, Therapeutic Ultrasound, and Electrical Current associated with a Silver Nanoparticle-containing ointment in the healing of wounds in Diabetic patients	Recruiting	Intervention	2025-09-09	<NULL>	<NULL>	8264	Effects of the combination of Electrophysical Agents and Silver Nanoparticles from green synthesis in the treatment of wounds in Diabetic patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-12	Claudio Teodoro de Souza	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6jn3xr9	<NULL>	Agree to participate in the study (sign the informed consent form); diagnosis of type 1 or 2 diabetes; present chronic wounds (wounds that do not close after 6 weeks); grade 2 wound, according to Wagner&apos;s classification (DIABETIC FOOT ULCER CLASSIFICATION SYSTEMS, 2016), which is: neuropathic and deeper, often penetrating the subcutaneous tissue, has infection, but without bone involvement, purulent secretion, inflammation and cellulitis.	Ingesting any supplement that aids healing, in pre- and post-operative procedures (e.g. impact diet); infected ulcer accompanied by cellulitis; osteomyelitis; received or will receive radiation during the study; had constant alcohol abuse 3 months before the start of the research; diagnosed with cancer; presence of wounds containing necrotic tissue, slough or fibrin necrosis; and inability of the patient to continue attending the clinic during follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-6nxjzt6	Clinical study to assess the Impact of Therapeutic Exercise on Cardiac Autonomic Function after Cardiac Surgery	Recruiting	Intervention	2022-11-21	<NULL>	<NULL>	5739	Impact of an individualized Therapeutic Exercise Protocol on Heart Rate Variability in the postoperative Heart Surgery: Randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Hospital universitário da Universidade Federal do Maranhão (HUUFMA)	Hospital universitário da Universidade Federal do Maranhão (HUUFMA)	https://ensaiosclinicos.gov.br/rg/RBR-6nxjzt6	<NULL>	Over 18 years of age; both sexes; undergoing heart surgery for myocardial revascularization, valve replacement or plasties, aortic surgeries and combined surgeries; provide written consent.	Neurological disorders that interfere with the ability to understand; heart surgery without cardiopulmonary bypass; inability to perform the proposed exercise protocol; surgical re-approach.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-4pfygr	Clinical study to assess the safety and tolerability of administration, directly into a vein, of human umbilical cord and placental blood plasma (Plasmacord®) in patients with Severe acute respiratory syndrome resulting from Sars-Cov-2 infection (fever, cough headache, muscle aches and difficulty breathing)	Not yet recruiting	Intervention	2020-08-13	<NULL>	<NULL>	4124	Clinical study to evaluate the safety and tolerability of intravenous infusion of plasma from human umbilical cord and placental blood (Plasmacord®) in patients with Severe Acute Respiratory Syndrome resulting from Sars-Cov-2 infection	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-07-27	CRYOPRAXIS - CRIOBIOLOGIA LTDA	CRYOPRAXIS - CRIOBIOLOGIA LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4pfygr	<NULL>	Age over 18 years; both sexes; positive test for COVID-19; indication for transfer to the intensive care unit (ICU) by the responsible medical team; according to institutional criteria and protocols; absence of therapeutic alternative	Pregnant women; under 18 years old; no indication of transfer to the intensive care unit (ICU) by the responsible medical team; according to institutional criteria and protocols; existence of therapeutic alternative	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-5497s9	Clinical study to assess the safety, and tolerability of multiple doses of orally administered JNJ-53718678 in infants hospitalized with RSV infection	Not yet recruiting	Intervention	2016-05-05	<NULL>	<NULL>	837	53718678RSV1005 - A Phase 1b, randomized, partially doubleblind, placebo-controlled study to assess the pharmacokinetics, safety, and tolerability of multiple doses of orally administered JNJ-53718678 in infants hospitalized with RSV infection	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2015-11-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - HCFMRP-USP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-5497s9	<NULL>	Inclusion Criteria: Participant has presented at the hospital for suspected Respiratory Syncytial Virus (RSV) infection within 72 hours prior to Screening completion; Participant has been hospitalized for this suspected RSV infection; Participant has been diagnosed with RSV infection using a polymerase chain reaction (PCR)-based assay, preferably commercially available locally; Participant was born after a normal term pregnancy (greater than or equal to 37 weeks and 0 days); A legally acceptable representative of the participant must sign an Informed consent form (ICF) indicating that he or she understands the purpose of and procedures required for the study, are willing for their child to participate in the study, are willing for their child to remain in the hospital for the first 3 days of dosing (even if not clinically indicated), and are willing/able to adhere to the prohibitions and restrictions specified in the protocol and study procedures	Exclusion Criteria: Participant who had major surgery within the 28 days prior to randomization or planned major surgery through the course of the study; Participant has major congenital anomalies or known cytogenetic disorders; Participant has known or suspected immunodeficiency, such as known human immunodeficiency virus (HIV) infection; Participant has known or suspected hepatitis B or C infection; Participant is upon current admission initially hospitalized in the Intensive care unit (ICU) and/or in need of invasive endotracheal mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-85bbp4	Clinical study to compare recombinant human growth hormone Cristália (r-hGH Cristália) versus Genotropin® pre puberty in children with failure to thrive due to deficiency of growth hormone.	Not yet recruiting	Intervention	2015-09-09	<NULL>	<NULL>	608	Clinical study to compare recombinant human growth hormone Cristália (r-hGH Cristália) versus Genotropin® in prepubertal children with growth deficiency due to deficiency of growth hormone.	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2015-10-01	ICF - Instituto de Ciências Farmaceuticas de Estudos e Pesquisas LTDA	Cristalia Produtos Químicos Farmacêuticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-85bbp4	<NULL>	Children aged 4 years and 13 years (for girls) and 14 years (for boys); Children prepubertal (Tanner stage 1); Bone age less than 11 years (for boys) and 9 years (for girls), documented by radiographs of the hand and wrist (will accept a radiograph performed within 6 months prior to enrollment in the study); Naïve children with growth hormone; Children diagnosed with disturbance in growth due to deficiency of growth hormone documented before initial treatment with r-hGH through: The height z score &lt;-2.0 SD for age and sex; A response to a test stimulus GH release with peak blood 7 ng / ml in the presence of abnormalities morphostructural hypothalamic-pituitary region shown by Nuclear Magnetic Resonance (NMR) or; response to stimulus two tests of GH release with peak  7 ng / ml in the presence of a normal NMR (stimulating agents are acceptable insulin, clonidine, glucagon, arginine and L-dopa). Historical values of GH in blood up to 12 months prior to enrollment in the study will be acceptable. An MRI performed up to 2 years before inclusion in the study is acceptable; History of growth velocity below the mean for the normal population for at least 6 months prior to inclusion in the study, according to the table of VC Tanner (must be historical height data with a minimum of 6 months and maximum of 18 months. Researcher must ensure that the measurements were performed in a standardized way in standard stadiometer (rigid deck and rigid ruler); Baseline IGF-I -0.5 SD for age and sex (results provided by the central laboratory).	"Children aged &lt;4 years; Children with clinical signs of puberty (breast / genitalia and pubic hair Tanner stage 2); Note: Children who enter puberty during treatment (breast development Tanner 2 / or testicles 4 ml or 2.5 cm in greatest diameter) shall be excluded; Other causes of disorder in children including growth in stature for gestational age (SGA), Turner syndrome, Prader-Willi syndrome, other causes; Children with closed epiphyses bone; Children with physical changes that prevent accurate measurement of height; Children with comorbidities that prevent normal growth. Patients with central hypothyroidism may be included, if well controlled with l-thyroxine, evidenced by normal free T4 dosages; dysmorphic syndrome; Presence of signs of skeletal dysplasia; Evidence of active malignancy or with less than two years of treatment considered curative; uncontrolled growth of benign intracranial tumors; Children with benign intracranial hypertension; Children with clinical evidence of malnutrition considered relevant to the discretion of the investigator; Children with Diabetes mellitus type 1 or 2; severe acute disease, including complications after heart surgery by thoracotomy, abdominal surgery, multiple accidental trauma or acute respiratory failure; concomitant chronic disease which may interfere with the analysis of the study (eg, hyperthyroidism / uncontrolled hypothyroidism, gastrointestinal diseases, cardio-respiratory diseases, liver failure, kidney failure, bone pathologies that can affect the growth, chronic inflammatory diseases and inborn errors of metabolism); Patients with hormone deficiency related diseases by panhypopituitarism may be included if properly controlled; MRI findings that may interfere with the study drug (examples: intracranial hypertension, tumors in the hypothalamic-pituitary region); Children with anti-GH antibodies;
Children undergoing treatment for the disorder or attention deficit hyperactivity disorder deficit hyperactivity disorder; Concomitant medication that could influence the secretion of growth (eg, estrogen, androgen, anabolic steroids, steroids, aromatase inhibitors) hormone. Physiological doses of corticosteroids for the treatment of pituitary deficiency are allowed as well as low-dose inhaled and / or nasal steroids for the treatment of asthma or chronic rhinitis (500mcg or less / day beclomethasone or equivalent); or known allergy to the study medications, or any of the excipients or thinner / solvent hypersensitivity; Participation in another clinical study within 3 months before study entry; Statement of legal limitation disability or parent / legal representative"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-10tn82jt	Clinical study to detect the presence of silicone oil released by syringes used for intraocular injection	Recruiting	Intervention	2022-10-18	<NULL>	<NULL>	5669	Detection of silicone oil from the syringe in the vitreous of patients undergoing intravitreal injection: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Hospital de Olhos de Sergipe	SJJ Solutions	https://ensaiosclinicos.gov.br/rg/RBR-10tn82jt	<NULL>	Over 18 years of age; both sexes; diabetic retinopathy, with indication for intravitreal injection of bevacizumab; clear ocular media and adequate pupillary dilation in both eyes to allow for all imaging procedures; visual acuity between 20/25 and 20/400; provide written consent; availability to come for exam 3 days after first injection and monthly for new exams and injection for 6 months	Severe glaucoma; age-related macular degeneration or retinal dystrophy; previous or current history of uveitis; previous vitreoretinal surgery; systemic contraindication to antiangiogenic therapy; presence of intraocular inflammation; any intraocular surgery in the previous 3 months; any eye infection; pregnancy or breastfeeding; any of the following conditions: severe heart disease, significant peripheral vascular disease; stroke in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-64gk7r	Clinical study to evaluate different adhesives in denture retention	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3065	Clinical, microbiological and patient-centered evaluation of different denture retention adhesives. Randomized crossover clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-26	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo.	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-64gk7r	<NULL>	Being clinically satisfactory users of total maxillary and mandibular prostheses (duration of prosthesis use is 1 year or less); properly understand both spoken and written Portuguese; be able to provide informed consent; being able to understand the study procedures and have the ability to perform them	"Presence of oral mucosal lesions such as denture-induced fibrous hyperplasia, papillomas or traumatic ulcerations associated with prosthesis bases or prosthesis-related stomatitis;
Impaired cognitive function;
Inability to attend returns for evaluation and maintenance;
Patients on medications such as antibiotics, antifungals, immunosuppressants, anticoagulants and corticosteroids during the last 3 months prior to the survey."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-4f9cdj	Clinical study to evaluate efficacy, safety and disease-free time with low-dose Oral Isotretinoin compared to Doxycycline in the treatment of papule pustular Rosacea	Recruitment completed	Intervention	2020-05-21	<NULL>	<NULL>	3857	Clinical trial to evaluate efficacy, safety and time of remission of Oral Isotretinoin in low dose compared to Doxycycline Hydrochloride in the treatment of papule pustular Rosacea	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2015-11-12	Universidade Federal De São Paulo - UNIFESP	Universidade Federal De São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-4f9cdj	<NULL>	Signature of the Free and Informed Consent Form (ICF) and Authorization Form for Photography before any study procedure; men or women aged between 20 and 75 years old, in good health; clinical diagnosis of papular pustular rosacea, with or without ocular involvement, with or without the presence of phyma, and who have been in the active phase of the disease for at least 1 month before the date of inclusion; participants must present on the day of inclusion at least 6 active lesions on the face (papules or pustules), that is, a score greater than or equal to 3 of the static score of 8 points for global assessment of rosacea by the investigator (Investigator&apos;s Global Assessment of Rosacea: 8 Point Static Score); absence of topical or systemic treatment, except sunscreens, for at least 3 months; absence of antibiotic therapy (cyclins, macrolides, metronidazole, azalides), for any reason, for at least 3 months; absence of previous treatment with oral isotretinoin or other systemic retinoid; absence of chemotherapy in the last 3 months; absence of a history of hypersensitivity to the study drugs; absence of infectious or other inflammatory dermatoses on the face; absence of clinical evidence or personal history of immunosuppression; absence of habit of drinking alcoholic beverages; absence of photodermatosis; absence of a previous or current history of collagen diseases; agreement to avoid sun exposure throughout the study and agreement with the conditions of the study, ability to understand and strictly follow the guidelines received and availability to attend periodic reevaluations.	Men and women who do not agree with the conditions of the study or without the ability to understand and strictly follow the guidelines received, without availability to attend periodic reevaluations or who refuse to sign the ICF; pregnant or lactating women; women of childbearing age and with sexual activity who refuse to use any method of contraception, such as oral, implantable, injectable or intrauterine contraceptives, introduced at least 120 days after the start of treatment; participant with exclusively phymatous rosacea (type 4); report of abuse of alcoholic beverages and / or illicit drugs; topical or systemic treatment, except sunscreens, for less than 3 months; use of antibiotic therapy (cyclins, macrolides, metronidazole, azalides), for any reason, for at least 3 months; previous treatment with oral isotretinoin; history of non-adherence to previous clinical treatments; previous or current history of collagen diseases; clinical evidence or history of immunodeficiency; use of any immunosuppressive and, or immunomodulatory medication in the last 3 months, topical or systemic; chemotherapy in the last 3 months; history of inflammatory bowel disease or regional enteritis and / or similar symptoms and any clinical observation made by the investigator that prevents participation in the study; presence of significant hepatic laboratory alterations, that is, values of transaminases 2 times above the upper limit of normality; diabetic patients, with fasting blood glucose values above 110mg / dl; presence of significant lipid changes (triglycerides above 300 mg / dl; total cholesterol above 250 mg / dl); presence of leukopenia (leukocytes under 3000 / mm3); history of hypersensitivity to isotretinoin and parabens or doxycycline hydrochloride; previous history of hypervitaminosis A; previous history of bone and or muscle changes and patients in use or who may need the following medications, for systemic use, due to the risk of interaction with the study drug: vitamin A or vitamin complexes with vitamin A up to 30 days ago; carbamazepine up to 7 days ago and cyclin class antibiotics up to 30 days ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-9r8drp	Clinical study to evaluate the blood levels of CA-125 and CD-23 substances and the amount of nerve fibers in the endometrium in patients with pain associated with Endometriosis: before and after 6 months of use of the Levonorgestrel-Releasing Intrauterine System (progesterone hormone IUD) or the Etonogestrel Subdermal Implant (Progesterone Hormone Implant)	Not yet recruiting	Intervention	2018-02-05	<NULL>	<NULL>	1626	A randomized clinical trial evaluating of CA-125 and CD 23 soluble  serum levels and nerve fibers in the endometrium of patients with pain associated with Endometriosis before and after 6 months of use of the Levonorgestrel-releasing Intrauterine System or the Etonogestrel Subdermal Implant	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-02-01	faculdade de ciencias medicas da universidade estadual de campinas	faculdade de ciencias medicas da universidade estadual de campinas	https://ensaiosclinicos.gov.br/rg/RBR-9r8drp	<NULL>	Women between age 18 to 45 years old, who entered at the study at the time of randomization and did not discontinue follow-up until the last visit in the previous study, 180 days after device insertion, these women already have a diagnosis and surgical staging or endometriosis imaging method (according to ASRM, 1997) and have reported chronic pelvic pain and / or dysmenorrhea with pain scores greater than or equal to 4 on the visual analog pain scale in the moment of randomization; agree to participate in the study and sign the informed consent term	Pregnancy; current proposoal to get pregnant; desire to only use the LNG-IUS as treatment and control of pain due to endometriosis; personal history of uterine Mullerian malformation or acquired uterine abnormalities, such as synechiae, or surgical absence of uterus; contraindications to the use of the LNG-SIU: current or recurrent pelvic inflammatory disease; acute infection of lower genital tract; present purulent cervicitis; history of miscarriage in the last three months; history of puerperal infection in the last three months; malignant uterine, cervical, hormone-dependent tumors; genital uterine bleeding with uncertain or undiagnosed etiology; conditions associated with increased susceptibility to infections; acute liver disease or malignant liver tumors; acute thromboembolism; hypersensitivity to levonorgestrel; contraindications to the use of the ENG implant: acute thromboembolism; malignant uterine tumors, hormones-dependent; genital uterine bleeding with uncertain or undiagnosed etiology; acute liver disease or malignant liver tumors; hypersensitivity to etonorgestrel or to any component of the implant; abuse of illicit drugs or alcohol; morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-2vfqnz	Clinical study to evaluate the effect of sublingual gel melatonin in healthy research participants	Not yet recruiting	Intervention	2020-06-08	<NULL>	<NULL>	3916	Monocentric phase I clinical study to assess the tolerability, safety and pharmacokinetics of sublingual melatonin gel in healthy research participants (PPES 003/19)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Instituto de Ciências Farmacêuticas	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-2vfqnz	<NULL>	Participant of both sexes, aged 55 or over. Survey participant with laboratory results, type 1 urine examination, clinical evaluation, vital signs, and ECG within normal range and / or any deviation from normality classified as not clinically significant.	Complementary test results are 3 times higher than normal values unless clinically irrelevant. Women who are breastfeeding. Participant with a history of hypersensitivity to the study drug or chemically related compounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-6nxst93	Clinical study to evaluate the efficacy and tolerability of the Meneguetti brush for self-collection of anal specimens to screen for anal cancer and sexually transmitted infections	Recruiting	Intervention	2023-02-09	<NULL>	<NULL>	8350	A crossover, randomized clinical trial to evaluate the efficacy and tolerability of the meneguetti brush in self-collection of anal specimens for screening of intraepithelial lesions and sexually transmitted infections	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-15	Instituto Nacional de Infectologia Evandro Chagas - Fiocruz	Laboratorio de pesquisa clínica em infecções sexualmente transmissíveis e síndrome da imunodeficiência humana	https://ensaiosclinicos.gov.br/rg/RBR-6nxst93	<NULL>	Participants aged 18 years or older will be included, with no history of anal cancer, pelvic radiotherapy, and/or anal canal stenosis, who report engaging in receptive anal sex and who are under care for the human immunodeficiency virus (HIV) or for HIV prevention at the Evandro Chagas National Institute of Infectious Diseases (INI/Fiocruz).	"Participants who report the following conditions will be excluded: 
History of hereditary or acquired coagulopathies; Platelet count below 50,000/µL; Surgical treatments in the anal canal within the previous 6 months; Use of topical medications in the anal canal (such as trichloroacetic acid or imiquimod) within the previous 3 months; High-resolution anoscopy, sigmoidoscopy, or colonoscopy within the previous 3 months; Anal sample collection, whether for anal cytology or other tests, within the previous 3 months; Use of anticoagulants in the last 5 days; Receptive anal sex, use of lubricants, topical products, creams, ointments, or suppositories, and/or anal washing or enema in the 24 hours prior to the visit; Anal complaints (anal pain, bleeding and/or discharge, or tenesmus) and/or findings during anal inspection (mass, ulceration, fissure, fistulous openings, discharge, prolapse, thrombosed hemorrhoids) on the day of screening. Participants presenting with hemorrhoids, warts, or anal skin tags (plicoma) that, in the proctologist&apos;s assessment, could interfere with sample collection or safety evaluation will also be excluded. These individuals will be referred to the institution&apos;s proctology outpatient clinic for clinical management and will be advised of the possibility of undergoing a new screening after the resolution of these conditions.Participants from Phase 1 are not eligible for participation in Phase 2 of the clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-2z27nc9	Clinical study to evaluate the perceived safety and efficacy, under normal conditions of use, of the unflavored denture fixative cream product by evaluating the acceptability in the oral mucosa	Not yet recruiting	Observational	2022-04-12	<NULL>	<NULL>	5340	A clinical trial to evaluate the safety of the investigational product denture fixing cream without flavor , evaluating the acceptability in the oral mucosa and perceived efficacy under normal conditions of use	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-25	Kosmoscience Ciência e Tecnologia Cosmética Limitada	Cimed Industria Sociedade Anônima	https://ensaiosclinicos.gov.br/rg/RBR-2z27nc9	<NULL>	Age range between 18 and 60 years. Female and male. Phototype (Fitzpatrick): I to VI. Being a user of removable dental prostheses (dentures). Be a user of products of the same category. Agree on procedures and requirements during study use: study time (after 21 days) laboratory to perform investigational product home study procedures, change the product study diary, do not change the study product study diary. Agree to perform facial aesthetic dermatological treatments until the end of the study (21 days), such as: peelings, laser, fillers, use of any unusual suitable products	Pregnant or lactating women. Participant who belongs to the risk group for COVID-19, that is, with cardiovascular, renal and chronic respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group. Presence of dermatoses, active skin lesions (local and/or disseminated) or irritation in the mouth region (internal or external). Expected vaccination during the study or up to 3 weeks before the study. History of oral pathologies. Use of non-steroidal anti-inflammatory drugs, corticosteroids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study. Be participating in another study in the same application region. History of non-adherence or unwillingness to adhere to the study protocol. Being undergoing dental treatment. Not taking vitamin A or derivatives. Any condition that, in the opinion of the researcher, could compromise the study. (To describe)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-6hq5qpr	Clinical study to evaluate the safety and efficacy of a transcranial electrical stimulation protocol in the treatment of tinnitus.	Recruiting	Intervention	2026-03-15	<NULL>	<NULL>	8978	Multicenter, randomized, controlled, phase 2 and 3 clinical trial to evaluate the safety and efficacy of a transcranial electrical stimulation protocol in the treatment of tinnitus.	<NULL>	2-3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal de Minas Gerais - Faculdade de Medicina	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; Individuals with hearing loss and a recommendation for hearing aids who complain of tinnitus; Individuals with normal hearing who complain of tinnitus.	Individuals under 18 years of age or incapacitated; Neurological or neurodegenerative disease that interferes with cognitive function; Use of a pacemaker or any other electronic device that may be affected by the use of TEE	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3w64rhx	Clinical study to explore the efficacy of a diaper changing products regimen in diaper rash prevention	Recruitment completed	Intervention	2025-02-05	<NULL>	<NULL>	7710	Pilot, comparative, monocentric clinical study to explore the efficacy of a diaper change regimen, composed by diaper, diaper rash cream and wet wipes, on diaper rash prevention (E005562C)	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-14	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	https://ensaiosclinicos.gov.br/rg/RBR-3w64rhx	<NULL>	Infants from 6 to 12 months old; both sexes; in good general health; free from diaper rash or presenting a mild to moderate diaper rash; legal guardians are more than 18 years old and have signed the informed consent form	Subjects who present any allergy and sensitivity to products of the same category of the investigational products; present any history and skin condition that may compromise the study results or the subject’s safety; and have used oral and/or topical antibiotics, antifungals, antihistamines and/or corticosteroids in the 2 weeks prior to enrollment visit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-2vm96f8	Clinical study to verify the best treatment for posterior deciduous teeth: Hall Technique or Resin-Modified Glass Ionomer Cement	Not yet recruiting	Intervention	2024-03-04	<NULL>	<NULL>	6822	Comparison of clinical success between Hall Technique and Resin Modified Glass Ionomer Cement in primary molars: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-05	Bianca Spuri Tavares	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2vm96f8	<NULL>	Children aged 4 to 8; of both sexes; with at least one primary molar affected by interproximal caries affecting dentin and without signs of pulp involvement; Surfaces with obvious carious lesions will be selected and will include ICDAS (International Caries Detection and Assessment System) code 4 underlying dark shade of dentin; 5 ICDAS (International Caries Detection and Assessment System)  distinct cavity with visible dentin; 6 ICDAS (International Caries Detection and Assessment System)  distinct extensive cavity that exposes dentin	Children who present systemic impairment; Children who are allergic to any dental material to be used; Primary teeth that present spontaneous pain or any indication of pulp involvement such as periapical or interradicular lesions; teeth with a history of trauma; teeth whose roots present more than 1/3 of rhizolysis; teeth with carious lesions located below the free gingival margin; teeth with great coronal destruction that do not allow the use of absolute isolation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-10nnzgqh	Clinical study to verify the effectiveness of two drugs to prevent inflammation of the Pancreas after performing the Endoscopic Retrograde Cholangiopancreatography procedure	Recruiting	Intervention	2023-10-03	<NULL>	<NULL>	6480	Prophylaxis for Acute Pancreatitis after Endoscopic Retrograde Cholangiopancreatography (ERCP): clinical, randomized, double-blind trial to evaluate the efficacy of Diclofenac versus Indomethacin and the benefit in risk groups	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-05-15	Faculdade de Medicina de Sao Jose do Rio Preto	Faculdade de Medicina de Sao Jose do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-10nnzgqh	<NULL>	Patients submitted to Endoscopic Retrograde Cholangiopancreatography; of both sexes; aged over 18 years	Patients under 18 years of age; pregnant women; nursing mothers; those who do not accept or are not able to perform the Endoscopic Retrograde Cholangiopancreatography Exam(s) and follow-up during the study; Patients who lost clinical and laboratory follow-up due to hospital transfer or early death from severe cholangitis; patients with Non-steroidal anti-inflammatory drugs (NSAID) allergy and contraindication for use (i.e., active peptic ulcer, serum creatinine &gt;1.4mg/dL, and single kidney) will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-9f3ctb	Clinical Study Toothpaste base Rosemary on Plaque and Saliva Bacterium	Recruitment completed	Intervention	2015-10-22	<NULL>	<NULL>	639	Clinical evaluation of the antimicrobial activity of the dentifrice the basis of Rosmarinus officinalis Linn extract. (rosemary) on the biofilm and saliva S. mutans	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2014-02-08	UFPE-Universidade Federal de Pernambuco	UFRPE-Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9f3ctb	<NULL>	"Healthy volunteers; both genders; aged 18 to 45 years; minimum of 20 healthy teeth in the mouth; without systemic diseases; without the use of drugs; healthy oral condition
Sample size : 110 patients"	Smoking volunteers; pregnant women; people with periodontal disease or decay; carriers of important systemic diseases; drug users; people with braces	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-2g27rd	Clinical study with the choice of patients who present wounds and the use of natural latex insole associated with light emitting circuit of leds for light therapy	Data analysis completed	Intervention	2018-12-06	<NULL>	<NULL>	2369	Randomized clinical trial of patients with wounds: natural latex and led light emitting circuit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-05	Faculdade do Gama	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-2g27rd	<NULL>	Patients intellectually fit, with diabetes mellitus and affected by foot ulcers of neuropathic origin. With or without clinical signs of infection and after completing and signing a consent form	Pregnant women; under 18 years or over 75 years of age; with history of alcohol or drug abuse; with symptoms and diagnoses of osteomyelitis, local tissue necrosis; with cognitive, neurological, or latex hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-9kb7km9	Clinical tests for the pelvic region	Recruitment completed	Observational	2021-02-23	<NULL>	<NULL>	4558	Validity and reliability of sacroiliac tests: Standing Flexion Test (STFT), Sitting Flexion Test (SIFT) and Downing test	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-07-26	Universidade Federal do Rio Grande do Sul - UFRGS	Universidade Federal do Rio Grande do Sul - UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-9kb7km9	<NULL>	The inclusion criteria for the study are: individuals aged between 18 and 60 years; non-obese; and without surgery on the lumbar, pelvis or hips	Exclusion criteria are: low back or hip pain on the day of collection; inability to perform the protocol tests, that is, not being able to flex the trunk, not being able to remain seated without backrest or supine; if the results of the STFT and SIFT are different from each other in the two measurements made by the rater A; and more than 2 cm in length difference between the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-8mf5x2	Clinical Trial comparative with and without use of Nimotuzumab for the treatment of Cervical Cancer with radiotherapy and Cisplatin	Not yet recruiting	Intervention	2014-01-15	<NULL>	<NULL>	270	A Phase III, Multicenter, Randomized, Two-arm Clinical Study: An Investigational Arm Containing Nimotuzumab in Combination with Radiation Therapy and Cisplatin, and A Control Arm with Radiation Therapy and Cisplatin for the Treatment of Stages IIb to IVa Uterine Cervical Carcinoma	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2014-01-02	Eurofarma Laboratórios S.A.	Eurofarma Laboratórios S.A.	https://ensaiosclinicos.gov.br/rg/RBR-8mf5x2	<NULL>	Be 18 years of age or older; have a histologically confirmed diagnosis of stage IIB to IVA squamous cell carcinoma, or adenocarcinoma, or cervical adenosquamous carcinoma, according to the IFGO system; life expectancy longer than 12 weeks; have measurable disease, according to the RECIST 1.1 criteria, or at least assessable by imaging and/or gynecological examination (imaging from up to six weeks prior to randomization will be accepted); indication for definitive treatment with chemotherapy and radiation therapy, according to the investigator’s opinion; performance status ? 2, according to the ECOG criteria; adequate bodily functions; have signed the informed consent form.	Involvement of para-aortic lymph nodes, by radiological and/or surgical staging, according to the investigator’s opinion; presence of severe co-morbidities, which –  according to the opinion of the investigator – will put the patient at a significantly higher risk or will impair compliance with the protocol; presence of neurological or psychiatric diseases or other significant conditions compromising compliance; known hypersensitivity or allergy to the study treatments; non-controlled hypercalcemia (&gt; 11.5 mg/dL, i.e., grade &gt; 1 according to CTCAE v4.02, of the American National Cancer Institute); known seropositivity to HIV; known and active hepatitis B or C; pregnant or lactating patients; patients – and their partners – refusing to use a proper contraceptive method during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-3kjd8x	Clinical trial comparing the utilization of Itraconazole and of Pentamidine for the treatment of Cutaneous Leishmaniasis in Amazonas	Not yet recruiting	Intervention	2020-02-11	<NULL>	<NULL>	3477	Itraconazole versus Pentamidine for the treatment of Tegumentary Leishmaniasis caused by Leishmania guyanensis in Amazonas - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-17	Fund. de Medicina Tropical Dr Heitor Vieira Dourado	Universidade do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3kjd8x	<NULL>	Patients with Ulcerated Cutaneous Leishmaniasis, not previously treated; diagnosed through at least one of the following tests: direct examinations of the lesion, biopsy of the lesion, culture or polimerase chain reactions (PCR) positives to Leishmania guyanensis; age of 18-65 years old; both genders; presenting at least 1 to 3 ulcerated lesions, in any localization; lesion diameter between 1-5 cm; clinical evolution not inferior to 1 month and not superior to 3 months.	Evidence of severe underlying disease (heart, kidney, liver, lung) or malignant disease; immunodeficient or HIV-infected patients; severe protein and / or caloric malnutrition; any active and uncontrolled infectious disease, such as tuberculosis, leprosy, systemic fungal disease (histoplasmosis, paracoccidioidomycosis); pregnant or nursing women; history of previous treatment for leishmaniasis; inability or willingness to provide informed consent (patient and / or / legal representative); lack of availability for visits or to comply with study procedures; patients participating in another ongoing clinical study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-10xhkk8c	Clinical trial comparing two copaíba-based treatments for skin tears	Recruiting	Intervention	2022-11-01	<NULL>	<NULL>	5693	Double blind randomized clinical trial, comparative between treatment with Copaifera Hayne multijuga 2% and 10% in skin tears	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Hospital Universitário Clementino Fraga Filho	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-10xhkk8c	<NULL>	People with skin tears up to 5 cm² in area	People under 18 or with other wound etiologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-3fthf8	Clinical trial evaluating the safety, neutralizing capacity and the lowest effective dose for antivenom treatment of multiple Africanized bees stings Apis mellifera	Recruitment completed	Intervention	2020-07-26	<NULL>	<NULL>	4035	Clinical trial phase I/II to evaluate the safety, the neutralizing capacity and the lowest effective dose of antivenom for the treatment of multiple africanized honey bees stings Apis mellifera- APIS Study	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Medicina de Botucatu	Benedito Barraviera	https://ensaiosclinicos.gov.br/rg/RBR-3fthf8	<NULL>	Be aged over 18 and under 60 years of both sexes; having a diagnosis of crash with bees Apis; have the consent of the patient or family to receive antivenom.	Have had frequent contact with products of horse; have had previous adverse reaction to receiving the antivenom; to be pregnant; be with chronic disease, including congenital and acquired immunodeficiencies; introduce diseases that the combined use contraindication antihistamines, corticosteroids and potent analgesics, including allergic reaction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-6347fv	Clinical trial for evaluation of the anti-plaque effect and gingival inflammation of a mouthwash containing chlorhexidine tetrapalmitate	Recruiting	Intervention	2019-06-11	<NULL>	<NULL>	2749	Development of mouthwash containing chlorhexidine tetrapalmitate and clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara	Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-6347fv	<NULL>	"To present a proven diagnosis of gingivitis;
Presence of plaque in 30% or more of the sites;
Presence of at least 5 teeth in each hemi-arch;
A negative history of antibiotic use in the last six months before the study;
A negative history of steroid or non-steroidal anti-inflammatory drugs in the last three months prior to or during the study."	"Received periodontal treatment in the last 12 months;
To present a systemic condition that interferes in the health-disease process;
Be pregnant or breastfeeding;
Be smoker;
Present allergy to chlorhexidine;
To present partial removable prosthesis or fixed prosthesis / maladaptive restorations; 
No attendance for sample withdrawal, form filling and periodontal evaluations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-9d5n4g	clinical trial for evaluation of Tooth Whitening in different application techniques	Recruiting	Intervention	2018-05-24	<NULL>	<NULL>	1847	Combined, At-home and In-Office Dental Bleaching: efficacy, clinical parameters follow-up and enamel evaluation of calcium and phosphorus concentrations	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Faculdade Centro de Pesquisa São Leopoldo Mandic	Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-9d5n4g	<NULL>	Inclusion criteria: aged 18 to 30 years, the presence of at least 20 teeth and the presence of the elements 11, 21, 22, 12, 13, 23, 31, 32, 33, 41, 42, 43 healthy or at most 1 / 6 restored labial surface.	The exclusion criteria of this study are: teeth with initial color B1 assessed by spectrophotometer (VITA Easyshade® Advance, Vita, Germany), patients with removable dentures or fixed and removable orthodontic appliances participants pregnant or breastfeeding, smoking participants, participants with prior dentinal sensitivity, presence of active caries lesions in enamel and dentin, periodontal disease and other oral lesions, pigmented teeth tetracycline and patients who received prior bleaching treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-8fnb6xx	Clinical Trial for the Evaluation of the Safety of the Product in Study Cream Gel through the Evaluation of Skin Compatibility under Normal Conditions of Use	Recruitment completed	Observational	2023-07-05	<NULL>	<NULL>	6208	Clinical Trial to Assess the Safety of the Research Product Cream Gel through Evaluation of Cutaneous Acceptability under Normal Conditions of Use	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Kosmosciense Ciência e Tecnologia Cosm Imp Exp Ltda	Kosmosciense Ciência e Tecnologia Cosm Imp Exp Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8fnb6xx	<NULL>	Age group between 18 and 70 years old. Female or male sex. Phototype (Fitzpatrick): I to VI. Have intact skin in the application region. Agree to adhere to the study procedures and requirements: study time, returns (after 21 days) to the laboratory to carry out the study procedures, home use of the product under investigation, filling in the use diary, not changing habits during the period of the study.  Agree to adhere to the requirements of the study in combating the COVID-19 pandemic, through preventive measures: use a mask in accordance with WHO guidelines, use the mask while traveling to the research center and during study procedures, maintain social distancing, wash your hands frequently with soap and/or alcohol gel and attend the research center only at scheduled times to avoid crowds	Pregnant or breastfeeding women, Participant who belongs to the risk group for COVID-19, that is, with chronic cardiovascular, renal and respiratory problems, immunosuppressed or other conditions that the investigator judges as belonging to the risk group, Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular, malformations, scars, increased hairiness, freckles and warts in large numbers, sunburn), Presence of dermatoses or active skin lesions (local and/or disseminated) in the study region. History of ineffectiveness, allergic reactions, irritation or feeling of intense discomfort to topical products. Prediction of vaccination during the study or up to 3 weeks before the study. History of pathologies aggravated or triggered by ultraviolet radiation. Use of non-steroidal anti-inflammatory drugs, corticoids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study.  Aesthetic or dermatological body treatment up to 4 weeks before the study. Hormonal treatments not stable in the last 3 months, if applicable. Hyperpigmentation associated with the use of drugs such as tetracycline, phenothiazides or amiodarone. Hyperpigmentation associated with photosensitivity. Actinic lichen planus. People directly involved in carrying out this study and their family members. Participating in another study. History of non-adherence or unwillingness to adhere to the study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-78vysg	Clinical trial for the subcutaneous recombinant human erythropoietin biosimilar in healthy adult male population	Not yet recruiting	Intervention	2019-10-30	<NULL>	<NULL>	3152	Phase I, monocentric, open-label clinical trial to determine the pharmacokinetics and pharmacodynamics of subcutaneous recombinant human erythropoietin in healthy adult male population	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-02-10	Laboratório Daudt Oliveira Ltda.	CAEP - Centro Avançado de Estudos e Pesquisas	https://ensaiosclinicos.gov.br/rg/RBR-78vysg	<NULL>	Informed Consent Form approved by IRB signed; male; age between 18 and 55 years; be characterized as a healthy research participant from medical history, general physical examination and vital signs, laboratory tests and ECG indicating no evidence of disease; have a BMI equal or greater than 18 and equal or less than 29.9 kg/m2; have a body weight of 60 - 100 kg; normal iron metabolism tests	Cardiovascular disorders and BP greater than 145/90 mmHg; history of venous thrombosis; presence of iron deficiency anemia or clinical history of autoimmune or hereditary anemia; clinical history of chronic or acute bleeding in the 30 days before the start of the trial; prior erythropoietin therapy; signs or clinical history of spinal cord aplasia; changes in the electrocardiogram that, at the physician&apos;s discretion, does not recommend the participant&apos;s stay in the trial; have a history of excessive alcohol consumption for at least 6 months prior to the trial (drinking 5 or more alcoholic beverages in one day or 15 or more alcoholic beverages per week); be a smoker or have quit smoking for less than 6 months; participant who consumes 5 or more cups of tea or coffee per day and cannot abstain during the trial period; participants with chronic diseases; hypersensitivity or contraindication of using the components of the medications studied; blood donation (more than 500 mL) or major surgery within 3 months prior to signing the Informed Consent Form; participation in clinical trial protocols in the last 12 months; any clinical condition or laboratory abnormality which, at the discretion of the investigator, could compromise trial participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-8jyhxh	Clinical trial for the treatment of COVID-19 with Chloroquine and Colchicine	Data analysis completed	Intervention	2020-07-30	<NULL>	<NULL>	4807	Randomized clinical trial for the treatment of moderate to severe cases of COVID-19 with Chloroquine and Colchicine	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-04-11	Hospital das Clínicas de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8jyhxh	<NULL>	Moderate or severe forms of COVID-19; 18 years or older; body weight of 50 kg or more; serum Ca2+ and K+ normal; QT interval lower than 450 ms at 12 derivations electrocardiogram; beta-HCG (serum or urine) negative (if woman under 50).	Mild and critical forms of COVID-19; allergy to any of the medications under study; diagnosis of porphyria, myasthenia gravis or uncontrolled arrhythmia at admission; pregnancy; use of digoxin, amiodarone, verapamil or metoprolol; use of protease inhibitors; history of chronic liver disease with liver dysfunction; unable to understand the information contained in the Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-28gq469	Clinical trial in patients with artificial respirator	Recruitment completed	Intervention	2020-12-09	<NULL>	<NULL>	4406	Impact of different levels of positive end-expiratory pressure on cardiac autonomic balance in patients using Invasive Mechanical Ventilation	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-22	FAPITEC / SE - Fundação de Pesquisa e Inovação Tecnológica Apoio do Estado de Sergipe	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-28gq469	<NULL>	Patients admitted to the ICU after 24 hours.	Age below 18 years; history of smoking or drinking; history of heart disease; coronary artery disease; kidney disease; neurological and metabolic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-4mdb59	Clinical trial involving patients with indication of endoscopic drainage of Pancreatic Collections with the aim to compare rates of displacement of two type of prothesis: with and without anti-migration systems	Recruiting	Intervention	2019-10-09	<NULL>	<NULL>	3059	Randomized clinical trial to evaluate the migration rate of fully covered self-expanding metal stent with anti-migration systems compared to fully covered self-expanding metal stent without anti-migration system in the Endoscopic Treatment of Fluid Pancreatic Collections	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-19	Hospital das clínicas da Universidade de Sao Paulo	Hospital das clínicas da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mdb59	<NULL>	Patients of any age; any gender; with the diagnosis of fluid pancreatic collection with definite ethiology of acute pancreatitis identified by abdominal radiological study after 4 weeks of onset of acute event; with symptoms such as pain or compression of the intra-abdominal organs by the collection or infected collections or causing sepsis	"Patient who refuses to sign the informed consent;pancreatic fluid collection with less than 4 weeks after acute pancreatis;Cystic Formation less than 6 centimeters and without symptoms;
food residues in the stomach during endoscopic exam;collection distant from the pancreas that prohibit endoscopic drainage because because it has no contact with the stomach or duodenum; evidence of bleeding inside of the collection; septic shock defined as an abdominal sepsis that does not respond to intravenous fluid and requires cardiac inotropic support or vasopressors"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-8bv3dz	Clinical Trial of a Paste Endodontic based on calcium hydroxide and Aloe Vera	Recruitment completed	Intervention	2020-04-02	<NULL>	<NULL>	3697	Effectiveness of Endodontic paste based on Calcium Hydroxide and Aloe vera: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Federal do Piauí	Centro Integrado Lineu Araújo	https://ensaiosclinicos.gov.br/rg/RBR-8bv3dz	<NULL>	Healthy volunteers aged 18 to 65, with at least an anterior tooth with apical periodontitis between 01 mm by 01 mm and 05 mm by 05 mm, requiring endodontic treatment.	Presence of history of allergies to materials used in the research; history of general health involvement, pregnant or lactating women; teeth with previous endodontic treatment history; teeth presenting calcifications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-3qnh96	Clinical trial of facial paralysis treatment.	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2091	Randomized clinical trial without treatment of peripheral facial palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-13	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-3qnh96	<NULL>	Participation of this study patients with medical indication for physical therapy; being in the chronic phase of the PFP with a minimum of 3 months after the injury; of different etiologies; presenting facial muscle dysfunction from Grade II to VI according to the House-Brackmann scale and who agree to be part of the independent study of the therapeutic resource that will be used.	Patients with a diagnosis of PF presenting grade I dysfunction according to the House-Brackmann scale will be excluded from the present study; which are in the initial phase of the disease and have hypersensitivity to phototherapy; skin irritation; eye problems; bacterial processes. Also excluded are patients with bilateral facial involvement and lesions or coarse facial features that may interfere with electrode contact and laser irradiation; with lack of understanding and who are performing other facial treatments simultaneously.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-53r6n7	Clinical trial of feasibility and verification of safety and efficacy of the transfemoral implant of the Inovare® valve	Recruiting	Intervention	2020-02-17	<NULL>	<NULL>	4945	"Implant of the Inovare® Transfemoral Transcatheter Valve
Feasibility and Verification of Safety and Efficacy Clinical Trial"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-20	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-53r6n7	<NULL>	Patients with significant calcified degenerative native aortic valve stenosis; Multidisciplinary evaluation by the &quot;Heart Team&quot; that concludes that the patient has a high surgical risk for aortic valve replacement or the presence of extreme fragility or the presence of comorbidities or aorta in porcelain or hostile chest; Symptoms of heart failure in NYHA functional class ≥ II; Aortic valve ring with an average diameter between 17.3 and 28.6 mm, documented by imaging method, suitable for positioning and accommodating the Inovare® prosthesis; Coronary ostia height&gt; 10 mm or presence of coronary graft that prevents the occurrence of acute myocardial ischemia due to coronary occlusion after the valve is released; Arterial femoral access route considered adequate for the progression of the vascular introducer and prosthesis-balloon system; Signed Free and Informed Consent Form.	"Clinicals: Hemodynamic instability with the need for vasoactive drugs or circulatory support; Valve procedure with clinical need to be performed in times of urgency or emergency (non-elective); Left ventricular ejection fraction &lt;30%; Chronic dialysis renal failure; Acute renal failure with serum creatinine that has not yet returned to baseline levels; Clinical or biological signs of infection with systemic repercussions; Endocarditis &lt;12 months; Coronary disease requiring elective revascularization during or after the valve procedure; Evidence of myocardial infarction in less than one month; Stroke or recent transient ischemic attack (in the last 6 months); Hypersensitivity or contraindication to the administration of heparin, ticlopidine or clopidogrel or to the radiopaque contrast medium; Anemia, thrombocytopenia or hyperthrombocytosis; Need for chronic anticoagulation for other causes; Active peptic disease, gastrointestinal bleeding &lt;3 months or previously diagnosed hemorrhagic diasteses; Life expectancy less than 12 months due to non-heart disease or other comorbidities.
Anatomical / morphological: Valve ring diameter less than or equal to 17.2 mm or greater or equal to 28.7 mm; Iliac-femoral access route, with extreme tortuosity or calcification or reduced luminal diameter, which prevents the safe progression of the arterial introducer and delivery system with the prosthesis; Presence of sessile and unstable atheroma in the ascending aorta and / or aortic arch detected by imaging methods; Obstructive hypertrophic cardiomyopathy or severe obstruction of the left ventricular outflow tract, with no possibility of balloon dilation; Previous aortic or mitral valve procedure (surgical or by catheter, excluding balloon aortic valvuloplasty); Moderate or severe aortic, mitral or tricuspid insufficiency; Native valve not calcified; Evidence of intracardiac mass."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-22fy6t	Clinical Trial of Lurbinectedin / Doxorubicin versus Cyclophosphamide, Doxorubicin and Vincristine or Topotecan as Treatment in Patients with Lung Cancer.	Not yet recruiting	Intervention	2017-10-23	<NULL>	<NULL>	1438	Phase III Randomized Clinical Trial of Lurbinectedin (PM01183)/ Doxorubicin (DOX) versus Cyclophosphamide (CTX), Doxorubicin (DOX) and Vincristine (VCR) (CAV) or Topotecan as Treatment in Patients with Small-Cell Lung Cancer (SCLC) Who Failed One Prior Platinum-containing Line (ATLANTIS Trial)	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-02-01	Hospital de Caridade de Ijui	INC Research	https://ensaiosclinicos.gov.br/rg/RBR-22fy6t	<NULL>	"Voluntary written informed consent of the patient; Adult patients aged more than 18 years; Diagnosis of limited or extensive stage small cells lung cancer (SCLC);  Small-cell carcinoma of unknown primary site with or without neuroendocrine; ECOG PS lower than 2; Adequate hematological, renal, metabolic and hepatic function in an assessment performed within 7 days (+ 3 day window) of randomization;	At least three weeks since last prior anticancer treatment and recovery to grade less than 1 from any AE related to previous anticancer treatment;	Prior Radiotheraphy (RT): At least four weeks since completion of whole-brain RT (WBRT), at least two weeks since completion of PCI, and to any other site not previously specified; Evidence of non-childbearing status for women of childbearing potential (WOCBP). WOCBP must agree to use a highly effective contraceptive measure up to six weeks after treatment discontinuation."	"More than one prior chemotherapy-containing regimen (including patients re-challenged with same initial regimen); 
Patients who never received any platinum-containing regimen for SCLC treatment; 
Prior treatment with PM01183, topotecan or anthracyclines;
Limited-stage patients who are candidates for local or regional therapy, including PCI, thoracic RT or both, must have been offered that option and completed treatment or refused it prior to randomization;
Impending need for palliative RT or surgery for pathological fractures and/or for medullary compression within four weeks prior to randomization;
Symptomatic, or steroid-requiring, or progressing CNS disease involvement during at least four weeks prior to randomization; 	Concomitant diseases/conditions:
History (within one year prior to randomization) or presence of unstable angina, myocardial infarction, congestive heart failure or clinically significant valvular heart disease;
Symptomatic or uncontrolled arrhythmia despite ongoing treatment;
Patients with any immunodeficiency, including those known to be or have been infected by human immunodeficiency virus (HIV);
Ongoing, treatment-requiring, non-neoplastic chronic liver disease of any origin,	Active infection or increased risk due to external drainages, Intermittent or continuous oxygen requirement within two weeks prior to randomization. Patients with confirmed or suspected diagnosis of diffuse interstitial lung disease (ILD) or pulmonary fibrosis, Patients with a second invasive malignancy treated with chemotherapy and/or RT. Patients with a previous malignancy that was completely resected with curative intention three or more years prior to randomization, and who has been continuously in remission since then will be permitted, Limitation of the patient’s ability to comply with the treatment or to follow the protocol, Documented or suspected invasive fungal infections requiring systemic treatment within 12 weeks of randomization; Pregnant or breast feeding women."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-57qbjv	Clinical trial of Methotrexate associated to Hydroxyurea versus placebo and Hydroxyurea in patients with sickle cell disease	Not yet recruiting	Intervention	2018-06-18	<NULL>	<NULL>	1909	Phase II, randomized clinical trial on the anti-inflammatory effect of Methotrexate associated to Hydroxyurea versus placebo and Hydroxyurea in pediatric patients and young adults with sickle cell disease and vaso-occlusive symptoms	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-08-01	Centro Infantil Boldrini	Centro Infantil Boldrini	https://ensaiosclinicos.gov.br/rg/RBR-57qbjv	<NULL>	Sickle Cell Disease patients; aged 08-30 years; patients who have vaso-occlusive pain episodes despite the regular use of hydroxyurea in the clinically-adjusted dose for a period equal or superior to 24 weeks	Absence of a signed Subject Information and Consent Form/Parents’ or legal guardian’s Informed Permission; renal or hepatic insufficiency; infection at enrollment time; pregnancy or breastfeeding; regular and/or frequent blood transfusions; refusal of contraceptive measures by females in reproductive age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-3p8g7n	Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects with Staphylococcus aureus Bacteremia Including Infective Endocarditis	Recruiting	Intervention	2016-08-03	<NULL>	<NULL>	1337	A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects with Staphylococcus aureus Bacteremia Including Infective Endocarditis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-06-01	Instituto Dante Pazzanese de Cardiologia	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3p8g7n	<NULL>	Male or female at least 18 years old at the time of consent; subject has signed an ICF; at least one blood culture positive for S. aureus within 48 hours before randomization; in addition to the QBC, subject must have at least one of the following signs or symptoms of bacteremia: temperature higher or equal to 38.0°C, white blood cell (WBC) count higher 10,000 or less than 4,000 cells/µL, or higher 10% immature neutrophils (bands) regardless of total peripheral WBC count; tachycardia (heart rate higher 90 bpm); tachypnea (respiratory rate higher 20 breaths/min); hypotension (systolic blood pressure less than 90 mmHg); signs and symptoms of localized catheter-related infection; subject must, at enrollment, have either 1) known right-sided infective endocarditis by Modified Duke’s Criteria, 2) known complicated bacteremia, demonstrated as signs or symptoms of metastatic foci of S. aureus infection, or 3) known bacteremia with at least one of the following risk factors for complicated bacteremia: any venous catheter considered to be the source of the infection, demonstrated by inflammation or purulent drainage from the catheter insertion site AND evidence of catheter-associated thrombosis upon removal; a central venous catheter considered to be the source of infection; a long-term intravascular catheter considered to be the source of infection; new onset cardiac murmur consistent with tricuspid regurgitation; community onset bacteremia; pathogen known to be MRSA at enrollment; duration of symptoms higher or equal to 2 days at time of presentation (prior to start of antibiotic therapy); skin exam findings suggesting acute systemic infection; willing to receive intravenous antibiotics for the duration of treatment; expected survival of at least 3 months; female subjects must be non-pregnant and non-lactating; if sexually active, must agree to use a highly effective method of birth control with partners of childbearing potential during the study and for 1 month after study drug dosing; considered likely to comply with the study procedures and to return for scheduled evaluations.	"Treatment with any potentially effective (anti-staphylococcal) systemic antibiotic for more than 60 hours within 7 days before randomization; requirement or anticipated requirement of non-study systemic antibiotics during the study; presence of an infection source that will not be managed or controlled within the first 3 days of study drug treatment; presence of prosthetic cardiac valve or cardiac device; known or suspected left-sided infective endocarditis (LIE), at enrollment, according to Modified Duke Criteria; at the time of enrollment, known or highly suspected osteomyelitis, meningitis, or metastatic septic foci involving the central nervous system (CNS); Known at the time of enrollment to have MRSA bacteremia that is non susceptible to daptomycin AND has a vancomycin MIC higher or equal to 2 microg/mL; confirmed evidence of a mixed polymicrobial infection with a Gram-negative pathogen that requires non-study antibiotic treatment with agent(s) that have activity against Gram-negative pathogens; previous participation in an anti-infective study during the past 12 months; history of significant hypersensitivity, allergy or intolerance to telavancin; solid organ transplantation or bone marrow transplantation within 6 months before randomization; severe neutropenia, defined as an absolute neutrophil count (ANC) less than 500 cells per microliter, or expected development of severe neutropenia during study; known or suspected human immunodeficiency (HIV) infection with a CD4+ T-cell count less than 200/µl within the previous 6 months; subjects requiring concomitant administration of anti-coagulation therapy AND requiring specific coagulation testing known to have interference by telavancin; severe liver disease, ie, Child-Pugh Class C, or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) more than 10 times the upper limit of normal (ULN); requirement for acute renal replacement therapy; or acute kidney injury (AKI) defined as an acute decrease in creatinine clearance (CrCl) to less than 30 mL/min and at least one of the following: higher or equal to 2x increase in serum Cr or 50% decrease in glomerular filtration rate (GFR) within the 2 weeks prior to enrollment (RIFLE stage 2 injury); oliguria defined as urine output less than 0.5 mL/kg per hour for higher ot equal to 12 hours at any time during screening; Shock or hypotension (supine systolic blood pressure 
less than 80 mm Hg) unresponsive to fluids or pressors within 24 hours prior to randomization; QTc higher than 460 ms (using either the Bazett or Fridericia formula), congenital long QT syndrome, uncompensated or new onset heart failure, aortic stenosis, aortic insufficiency, or mitral insufficiency; serum creatine kinase (CK) higher or equal to 2000 U/L; breast-feeding or pregnant or intending to become pregnant (self or partner) at any time during the study; any other condition that in the opinion of the investigator would jeopardize the safety or rights of a subject or would render the subject unable to comply with the protocol; or any other condition that in the opinion of the investigator may confound the data."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-8w44f6	Clinical trial of the effect of breathing exercise on expiratory force and abdominal muscle in stroke patients	Not yet recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3024	Effect of Respiratory Muscle Training on expiratory muscle strength and abdominal electrical activity in the acute phase of Stroke: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-05	Hospital das Clínicas da Faculdade de Medicina de Botucatu - UNESP	lorena	https://ensaiosclinicos.gov.br/rg/RBR-8w44f6	<NULL>	Patients aged 18 years and under 80 years of age admitted to the stroke unit of the Clinical Hospital of the Botucatu Medical School, with clinical diagnosis of ischemic stroke by magnetic resonance or computed tomography with up to 80 years will be evaluated. 72 hours of the ictus, absence of disability prior to hospitalization with score less than or equal to 1 in eMR, item 1a (level of consciousness), 1c (Commands: open / close eyes, shake and release hand), language and facial paresis NIHSS less than equal to 1, no previous dementia or other associated neuromuscular diseases, no severe valvulopathy and previous major thoracic or abdominal surgery under 1 year, no congestive heart failure class III and IV, no asthma or decompensated chronic obstructive pulmonary disease (COPD) with a closed diagnosis.	Patients with previous complaints of dysphagia, clinical instability, invasive mechanical ventilation or palliative care will be excluded, those who fail to perform the MIP / MEP assessment protocol, ventilometry, non-adaptation to training, worsening of clinical and hemodynamic status and those who do not agree to participate in the study or refuse to continue the training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-7t8fv7	Clinical trial of the effectiveness of telephone nursing care to individuals with inflammatory bowel disease	Not yet recruiting	Intervention	2016-07-25	<NULL>	<NULL>	937	The telenursing in the treatment of inflammatory bowel diseases: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Policlínica Piquet Carneiro da Universidade do Estado do Rio de Janeiro	Policlínica Piquet Carneiro da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7t8fv7	<NULL>	volunteer with Crohn disease in remission and light activity; volunteer with ulcerative colitis in remission and light activity; both genders; aged between 18 and 60 years.	volunteers with cognitive disorder; volunteers without acess to phone; volunteers with special needs that preclude the telenurssing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-8w4bjf8	Clinical trial of treatment with Transcranial Magnetic Stimulation (brain stimulation) in negative symptoms of Schizophrenia	Recruiting	Intervention	2024-07-26	<NULL>	<NULL>	7160	Randomized, double-blind, sham-controlled clinical trial, of Transcranial Magnetic Stimulation intervention with Theta Burst (iTBS) in negative symptoms of Schizophrenia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-15	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-8w4bjf8	<NULL>	Individuals diagnosed with Schizophrenia (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM 5); aged 18 to 50; both genders; presenting with moderate intensity negative symptoms; capable of reading and understanding Portuguese; with stable use of medications and no changes in antipsychotics in the last three months; not using anticonvulsant medications; not having abused drugs or alcohol in the past year; not having undergone any brain stimulation protocols in the past year before admission to the study	Individuals diagnosed with depression or substance abuse dependency, as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); diagnosed neurological disorders (epilepsy and history of seizures, traumatic brain injury); presence of metallic implants in the brain region (pacemakers, cochlear implants, implanted electrodes/stimulators, aneurysm clips/coils, stents)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-2w4dpg5	Clinical trial on central catheter cutting	Recruitment completed	Observational	2022-03-29	<NULL>	<NULL>	5313	Randomized controlled clinical trial on cutting peripherally inserted central catheters	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-02-05	Clélia Mozara Giacomozzi	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2w4dpg5	<NULL>	Newborns hospitalized during the data collection period, who have the peripherally inserted central catheter indication and who have successfully performed the insertion procedure, whose guardians authorize participation	Newborns whose guardians do not authorize participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-3ysnwj	Clinical trial on the effects of a Hydrotherapy protocol Neonatal Intermediate Care Unit	Recruiting	Intervention	2016-05-05	<NULL>	<NULL>	834	Clinical trial on the effects of a Hydrotherapy protocol Neonatal Intermediate Care Unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Fundação de Amparo à Pesquisa do Estado de São Paulo	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3ysnwj	<NULL>	preterm infants with gestational age less than or equal to 32 weeks ; Hospitalized Neonatal Intermediate Care Unit; in spontaneous breathing ; without central or peripheral venous access ; babies without congenital malformations or chromosomal syndromes or infections in treatment ( change of blood count and blood culture positive ) or neurological disorders ( intracranial hemorrhage grade III or IV, and brain malformations ) ; without skin lesions or other contraindications to body immersion in hot water	adverse reactions to the study protocol (cyanosis , crying or lethargy, facies pain , generalized hyperemia , among others); Epidermal changes ; worsening of symptoms ; intolerance to food or behavioral disorders; events that prevent the study protocol ( need for ventilatory support or intravenous and surgical procedures ) ; parents and / or guardians who request to withdrawn from the infant study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-7nrvmmm	Clinical trial on the incidence of complications related to the insertion of more than one Central Venous Access into the internal jugular vein	Not yet recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7052	Incidence of complications related to multiple Central Venous Access in the internal jugular vein: multicenter randomized non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição	Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7nrvmmm	<NULL>	Patients over 18 years of age; ASA I to IV; scheduled for heart surgery; vascular surgeries; abdominal surgeries; major thoracic surgeries; liver transplants; lung transplants; with anesthetic planning for the insertion of at least two central venous catheters	Patients with a previous history of central venous thrombosis; or central venous stenosis; patients under 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-96bp2pb	Clinical trial phase 1/2 to verify the safety of oral clarified açaí extract in acute ischemic stroke	Not yet recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7697	Randomized and controlled clinical trial, single-center phase 1/2, to verify the safety of oral clarified açaí extract in acute ischemic stroke (AÇA-ICTUS study)	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-02-01	Instituto de Ciências da Saúde da Universidade Federal do Pará	Hospital da Aeronáutica de Belém	https://ensaiosclinicos.gov.br/rg/RBR-96bp2pb	<NULL>	Age 18 years or older; diagnosis of ischemic stroke on admission; absence of bleeding on admission cranial tomography; National Institute of Health Stroke Scale equal or higher than 5 on admission; possibility of administering treatment within 24 hours from the onset of symptoms	Previous moderate functional disability (modified Rankin Scale equal or higher than 3); indication of thrombolytic therapy (chemical, mechanical); inability to tolerate or accept study procedures; co-occurrence of other serious clinical emergencies/urgencies on admission (e.g., cardiopulmonary arrest, acute respiratory failure, septic shock, status epilepticus, signs of intracranial hypertension); National Institute of Health Stroke Scale equal or higher than 20 on admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-664747m	Clinical trial to assess the rapid diagnostic test for detecting SARS-CoV-2 through breath analysis	Recruiting	Intervention	2022-02-18	<NULL>	<NULL>	5230	Multicenter, adaptive, and single-blind clinical trial to assess the predictive value of the rapid diagnostic test for detecting SARS-CoV-2 through breath analysis	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2021-11-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	BOH Brasil Serviços Diagnósticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-664747m	<NULL>	Both genders; Age higher or equal to 08 years completed at inclusion; Subjects to be tested for SARS-CoV-2 infection by RT-PCR or with collection of the RT-PCR test or Viral Panel and BOH within 48h between them.	Inability to fill the air bag; Persons under guardianship or deprived of liberty; Acute Obstructive Pulmonary Disease, which makes it impossible to fill the air bag.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-3crsfj	Clinical trial to compare the efficacy and safety between the combination of dorzolamide hydrochloride (2%) + brimonidine tartrate (0.2%) + timolol maleate (0.5%) and COMBIGAN® (combination of 0.2% brimonidine tartrate + 0.5% timolol maleate) in reducing ocular pressure in adult patients with primary open-angle glaucoma or high pressure in the eyes	Not yet recruiting	Intervention	2020-01-20	<NULL>	<NULL>	3381	Phase III, multicenter, double-blind, randomized, controlled, 12-week, parallel-group, superiority trial to compare the efficacy and safety of the triple fixed combination of dorzolamide hydrochloride (2%) + brimonidine tartrate (0.2%) + timolol maleate (0.5%) versus COMBIGAN® (double fixed combination of 0.2% brimonidine tartrate + 0.5% timolol maleate) in reducing intraocular pressure (IOP) in adult patients with primary open-angle glaucoma or ocular hypertension	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-06-01	Laboratório Daudt Oliveira Ltda.	Centro de Pesquisa Clínica São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-3crsfj	<NULL>	Men or women aged 18 years-old or over; having a diagnosis of primary open-angle glaucoma or ocular hypertension; being able to sign the ICF approved by IRB and to execute and understand all study procedures and instructions; having intraocular pressure greater than or equal to 21 and less than or equal to 30 mmHg in, at least, one eye; having an optical disc excavation of 0,8 or less	"Presenting blindness in one eye; having visual acuity worse than or equal to 20/40 in either eye without justified cause; presenting a history of any concomitant active-stage eye disease, except those specified in
inclusion criteria; for participants taking medication to treat primary open-angle glaucoma or ocular hypertension may only participate in the study if they discontinue the drug for a period of up to 7 (± 2) to 30 (± 2) days, according to the therapeutic class of the medication used; making use of topical corticosteroids ophtalmic or topical within
14 days from the screening visit. It is prohibited the use of systemic corticosteroids and psychotropic medicines with adrenergic potential (eg desipramine, amitriptyline) within 1 month of the screening visit or any other medication which, regardless of the route of administration, interfere with the study results and offer a risk to the participant&apos;s safety, at the investigator&apos;s discretion, used within 48 hours prior to the screening visit or until residual effects may be present; having an allergy to sulfa drugs; having hypersensitivity to the active ingredients and excipients of the study medications; wearing contact lenses 7 days before the screening visit (pre-treatment) and throughout the study; current history of bronchial asthma or chronic obstructive pulmonary disease (COPD), sinus bradycardia, 2nd or 3rd degree heart block, heart failure, cardiogenic shock; current or previous history of severe renal or hepatic impairment,
current history of diabetic retinopathy or any other clinical condition that, at the investigator&apos;s discretion, contraindicates participation in the study or interferes with the study outcome; participants of childbearing age who do not agree to use a
adequate form of contraception; pregnant, nursing women who plan to become pregnant, or who have a positive pregnancy test on their blood test; having a history of cataract surgery with or without intraocular lens (IOL) implantation (pseudoaphakia or aphakia) within 3 months or less prior to the screening visit; having a recent history of alcohol and/or drug abuse or excessive alcohol consumption; presenting corneal abnormalities that interfere with an accurate reading of intraocular pressure by a Goldmann applanation tonometer; being part of a clinical study within the last 12 months unless, at the discretion of the investigator, it represents a benefit to the participant"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-3j6jwg3	Clinical trial to evaluate intralesional Meglumine Antimoniate associated with topical Imquimod in the treatment of Cutaneous Leishmaniasis	Recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7253	Randomized clinical trial to evaluate the efficacy and safety of Intralesional Meglumine Antimoniate associated with topical Imiquimod in the treatment of Cutaneous Leishmaniasis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2024-06-20	Empresa Brasileira de Serviços Hospitalares - EBSERH	Empresa Brasileira de Serviços Hospitalares - EBSERH	https://ensaiosclinicos.gov.br/rg/RBR-3j6jwg3	<NULL>	Diagnosis of CL with up to 3 lesions, up to 5 cm in diameter, ulcerated or not, with confirmation by one or more methods (direct examination, histopathology, culture, polymerase chain reaction, indirect immunofluorescence or Montenegro intradermal staining), without previous treatment or treated more than 6 months ago; age greater than or equal to 18 years; both sexes; hormonal and barrier contraceptive method, in the case of female patients of childbearing age; completion of the free and informed consent form (TCLE)	Other forms of acute tegumentar leishmaniasis other than cutaneous; injuries located on the cephalic segment; pre-treatment electrocardiographic changes that contraindicate the use of pentavalent antimony; women of reproductive age without an effective contraceptive method or used inappropriately; pregnant and breastfeeding women; diagnosis of human immunodeficiency syndrome (AIDS); previous hypersensitivity reaction to AM or imiquimod; inability to understand and complete the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-10mpz6sd	Clinical trial to evaluate monkeypox vaccine response in persons previously exposed to monkeypox virus	Recruiting	Intervention	2023-07-11	<NULL>	<NULL>	6225	Adaptive clinical trial to evaluate the Post-Exposure Effectiveness and Safety of the MVA-BN/ Jynneos vaccine for Mpox	<NULL>	4, n/a, open	4	<NULL>	<NULL>	<NULL>	2022-12-13	Instituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-10mpz6sd	<NULL>	Minimum age of 15 years. Both genders. Had contact with an individual diagnosed with suspected, probable or confirmed Mpox by PCR RT and with a high degree of exposure characterized as: contact of continuity lesions on the skin (non-integrated/mucous skin) or mucous membranes of the exposed individual with skin lesions or body fluids of person with Mpox. Had any sexual contact or intimate relationship involving mucous membranes (e.g. kissing, oro-genital contact, oro-anal contact, vaginal contact, or anal sex) with a person with Mpox. Had contact of skin lesions (non-integrated/unhealed skin) or mucosal contact of the exposed individual with materials (e.g., fomites, clothing, sex toys) that have had contact with the skin lesions or body fluids of the person with Mpox (e.g., sharing food, handling or sharing fomites (bedding) without washing them). Professional accidentally exposed to the biological sample of a patient diagnosed with Mpox. Be available to perform the project visits. To sign the Free and Informed Consent Form and/or the Term of Consent, the latter in the case of minors under 18 years of age	Known allergy to any of the vaccine components, especially with severe forms of allergy to egg, quinolone class antibiotics and/or aminoglycosides. Pregnant and lactating women. Presenting signs and/or symptoms of Mpox (sudden onset of mucosal lesion), and/or acute rash suggestive of Mpox, single or multiple, anywhere on the body (deep and well circumscribed lesions, often with central umbilication; and progression of the lesion through specific sequential stages - macules, papules, vesicles, pustules, and crusts), including genital/perianal, oral, and/or proctitis - e.g. anorectal pain, bleeding – and/or penile edema, and may be associated with other signs and symptoms). Have received any Mpox vaccine in the last 12 (twelve) months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-3bhzqsm	Clinical trial to evaluate superior efficacy and safety of the association of Diltiazem hydrochloride 2% + Lidocaine hydrochloride 2% perianal gel in relation to Proctyl® rectal ointment (Policresulene 50 mg/g + Cinchocaine hydrochloride 10 mg/g) in the treatment of chronic Perianal Fissure	Not yet recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7603	"DLG Protocol: Phase III, multicentre, single-blind, parallel, randomized clinical trial to evaluate the
superior efficacy and safety of the fixed-dose combination of diltiazem hydrochloride 2%
+ lidocaine hydrochloride 2% perianal gel compared to Proctyl® rectal ointment
(polyresulene 50 mg/g + cinchocaine hydrochloride 10 mg/g) in the treatment of chronic
perianal fissure"	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2024-12-20	Irmandade da Santa Casa de Misericórdia de Santos	Laboratórios Ferring LTDA.	https://ensaiosclinicos.gov.br/rg/RBR-3bhzqsm	<NULL>	Participants capable of reading, or following along with the reading, understanding, and signing the informed consent form approved by the research ethics committee system; of both sexes; aged 18 years or older; capable of adequately communicating with the investigator and the clinical study team; diagnosed with chronic anal fissure; female participants without the potential to become pregnant; agree to use a safe contraceptive method; agree not to have anal intercourse during the study period	Participants diagnosed with malignant disease in the last 5 years, except for successfully treated basal cell carcinoma; those with chronic diseases on regular medication that, at the investigator’s discretion, may interfere with the clinical study; participants who show hypersensitivity or contraindication to any of the components of the formulations; female participants who are breastfeeding, planning to become pregnant, or who test positive for pregnancy during the study period; any clinical observation (clinical/physical evaluation) that is interpreted by the investigator as a risk to participation in the clinical study; participants who refuse to undergo visual or medical examination of the anal fissure; participants with more than one anal fissure; participants with anal fissure associated with or caused by other conditions, including but not limited to: drug-induced, trauma, human immunodeficiency virus (HIV) infection, anal fistula, inflammatory bowel disease, perianal sepsis, or malignancy; participants who refuse to discontinue all other concomitant topical preparations applied in and around the anus from the day before the start until the end of the clinical study; use of sitz baths from the signing of the informed consent form (ICF) until the end of the clinical study; use of anesthetics from the signing of the ICF until the end of the clinical study; injection of botulinum toxin into the anal fissure within 3 months prior to signing the ICF; participants actively treated with antiviral therapies for HIV (e.g., indinavir, nelfinavir, ritonavir); participants treated with any prohibited medication within 14 days prior to signing the ICF such as: cytochrome P450 (CYP450) inhibitors and inducers; cytochrome P3A4 (CYP3A4) substrates, inhibitors, and inducers; benzodiazepines; β-adrenoceptor antagonists (Beta-Blockers); calcium channel blockers; digoxin; opioids; participants with any of the following concomitant conditions: sick sinus syndrome, except in the presence of a functioning ventricular pacemaker; second or third-degree atrioventricular block, except in the presence of a functioning ventricular pacemaker; hypotension (systolic pressure less than 90 mmHg); history of reduced left ventricular function, bradycardia, first-degree atrioventricular block, or prolonged PR interval (&gt; 0.2 seconds / &gt; 200 milliseconds) on electrocardiogram; documented acute myocardial infarction and pulmonary congestion by radiography; history of active uncontrolled diabetes and/or hypertension; current infection treated with a macrolide antibiotic; clinical evidence or history of fecal incontinence; clinical evidence or history of chronic constipation or constipation in the 4 weeks prior to signing the ICF (defined as 2 or fewer bowel movements per week; associated with straining/passage of hard stools); clinical evidence or history of anal fistula; clinical evidence or history of anal abscess; clinical evidence or history of fixed anal fibrosis; history of inflammatory bowel disease or active gastrointestinal disorders (e.g., inflammatory bowel disease, Crohn’s disease, ulcerative colitis); history of any previous anal or rectal surgery, including but not limited to: lateral sphincterotomy and anal dilation or other previous surgery involving the anal canal or perianal region; history of pelvic radiotherapy; participants with associated acute hemorrhoidal crises; participants with anal or perianal cancer; participants with a history of cardiac (any), renal (resection or renal agenesis), gastrointestinal (partial or total removal of the esophagus, stomach, duodenum, jejunum, ileum, ascending colon, transverse colon, descending colon, sigmoid colon, or rectum) and liver or pancreas surgery, as well as a history of transplantation; having any planned surgery that may interfere with the successful completion of the clinical study; participants who have received therapy with diltiazem hydrochloride gel or other topical calcium channel blockers or other topical medicinal ointments, which at the physician’s discretion may interfere with the outcome of the clinical study, 3 days before signing the ICF; participants using oral calcium channel blockers, nitrates (e.g., glyceryl trinitrate GTN), or any other vasodilators; any clinically significant condition of renal, hepatic, neurological, dermatological, immunological, psychiatric (including drug or alcohol users) or hematological disease or any clinically significant abnormal laboratory findings that, at the investigator’s discretion and from medical records, may compromise participation in the clinical study; presenting a positive preliminary drug test result for amphetamine/methamphetamine, opiate/morphine, marijuana/tetrahydrocannabinol, cocaine/benzoylecgonine, and/or benzodiazepine; research participants who have participated in clinical study protocols in the last 12 months (National Health Council Resolution CNS 251, August 7, 1997, item III, subitem J), unless there may be direct benefit to the research participant, at the investigator’s discretion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-8v3tkq	Clinical trial to evaluate the effectiveness and safety of the laser to control the pain caused by orthodontic treatment	data analysis completed	Intervention	2012-05-28	<NULL>	<NULL>	125	Evaluation of low level laser terapy(LLLT) for the treatment of pain associated with positioning elastomeric orthodontic interdental separators	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-06-28	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-8v3tkq	<NULL>	"Chronological age greater than 12 years; 
Presence of erupted permanent first and second lower molars; Presence of erupted first and second premolars; 
Voluntary participation in the study confirmed by signing the informed consent form."	"Patients using antibiotics or analgesics; 
Pregnant or breastfeeding women; 
Patients with cardiac disease; 
Systemic diseases; 
Contraindications for NSAIDs use; 
Surgical procedure during the preceding two weeks; 
Gastrointestinal illness (gastritis, gastric ulcer, lactose intolerance, chronic diarrhea or intestinal inflammatory illness); 
Melanin pigmentation in the gingiva in the area to be irradiated;
Treated or untreated apical bone lesions; 
Diastema in the region of the molars and/or premolars."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-4n5f5jb	Clinical trial to evaluate the use of the medication Esketamine with intravenous administration in association with the treatment of patients with severe depression who present with hallucinations and delusions	Recruiting	Intervention	2023-05-14	<NULL>	<NULL>	6073	Randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of using intravenous Esketamine as an adjunct in the treatment of Psychotic Unipolar Depression	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal da Bahia	Hospital Universitário Professor Edgard Santos	https://ensaiosclinicos.gov.br/rg/RBR-4n5f5jb	<NULL>	Patient aged between 18 and 65 years, diagnosed with unipolar depression with psychotic symptoms, according to clinical evaluation and diagnostic criteria for unipolar depression of the Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5), evaluated using MINI 7.0.2 (The Mini International Neuropsychiatric Interview), with a score of 20 or more on the MADRS scale at baseline; The assessment of psychotic symptomatology will be performed using item 15 of the BPRS, including patients with scores greater than or equal to 3 (i.e., without belief change after reality testing); The duration of the current depressive episode must be at least 4 weeks.	Patients diagnosed with primary psychotic disorders - such as schizophrenia, schizoaffective disorder, brief psychotic disorder - will be excluded, as well as patients with bipolar affective disorder, current substance use disorder according to DSM-5 criteria; patients in a state of mutism or catatonic stupor; patients with dementia or intellectual disability; pregnant or lactating patients; patients with uncompensated general medical conditions or general medical conditions whose psychotic and/or depressive symptoms may be a direct manifestation; and first-degree family members of investigators. Furthermore, patients with depressive symptoms attributed mostly to other psychiatric diagnoses other than MDD will be excluded, as in the case of patients with severe personality disorders; Patients undergoing treatment with electroconvulsive therapy (ECT) in the current episode will also be excluded; Hypertensive patients who are decompensated and refractory to antihypertensive measures at pre-infusion times will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-73gfct	Clinical trial to evaluated the efficacy and safety of  Maxsulid® (Cosmed) compared to Nisulid® (Aché) medicine in the treatment of postoperative pain of wisdom teeth extraction.	Not yet recruiting	Intervention	2019-02-12	<NULL>	<NULL>	4258	No inferiority Phase III clinical trial, randomized, multicentre, parallel and blind to evaluated the efficacy and safety of  Maxsulid® (Cosmed) compared to Nisulid® (Aché) medicine in the treatment of postoperative pain of third molar extraction.	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2019-06-30	Brainfarma Indústria Química e Farmacêutica S.A.	Brainfarma Indústria Química e Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-73gfct	<NULL>	Sign the Informed Consent approved by the Ethics Committee,age greater than or equal 18 years old, participants of both sexes, have a third molar removal dental surgery in the last few hours and have a pain assessment on the VAS scale at least 50 mm.	Have used anti-inflammatories or analgesics of any nature in the last 48 hours; Have a history of peptic ulcer or gastrointestinal bleeding; Illness of any nature that contraindicates participation in the study; Is not able to understand and perform the pain assessments present in the study; Hypersensitivity or contraindication known to the medications or components of the medications studied; Pregnant or lactating women; Professionals and their relatives who are directly involved in the process during this study; Participation in another study in less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-5r8gv8p	Clinical trial with convalescent plasma for Covid-19 therapy	Suspended	Intervention	2021-07-07	<NULL>	<NULL>	4778	Antibodies in Covid-19 therapy: phase IIa clinical study with convalescent plasma and generation of human monoclonal antibodies	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-06-13	Universidade de Brasília	Fundação Hemocentro de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5r8gv8p	<NULL>	Plasma donor: be between 18 and 60 years old; be male or a female that has never been pregnant; weight at least 60 kg; have SARS-CoV-2 infection confirmed by positive RT-PCR; be eligible for blood donation, according to the appropriate Brazilian law (Seção II da Portaria de Consolidação n.5, de 28 de setembro de 2017); agree to participate in the study and sign the informed consent form(s); have no Covid-19 symptoms for 14-27 days, in which case a new RT-PCR test from a nasopharyngeal or oropharyngeal swab has to be negative OR have no Covid-19 symptoms for 28 days or more, in which case no additional tests are necessary; have a positive result on a SAR-CoV-2 IgG test. Plasma transfusion receptor: be 18 years or older; have been admitted to a hospital to treat moderate Covid-19, defined as compatible clinical characteristics, such as dyspnea and/or fever and/or cough plus chest computed tomography with bilateral ground glass opacities; have SARS-CoV-2 infection confirmed by nasopharyngeal and/or oropharyngeal swab PCR or serological assay that detects IgM or SARS-CoV-2 antigen; have Covid-19 symptoms for no more than 10 days.	Plasma donor: at the interview and research subject selection stage: history of severe Covid-19 in the last 30 days (septic shock, cardiac arrest or intubation for more than two days); previous history of coagulation diseases than could increase the venous access risk; previous history of hemoglobinopathies that could increase the plasmapheresis risk; situations that prohibit blood donations, according to Brazilian law (Portaria de Consolidação n.5, de 28 de setembro de 2017). At the pre-plasmapheresis stage: positive result in an irregular antibody test made with serum collected during triage; detection of anomalous hemoglobin (e.g. sickle cell trait) in a whole blood sample obtained during triage; negative result on a test for SARS-CoV-2 IgG; ineligibility for blood donation identified during triage, as specified at the relevant Brazilian law (Portaria de Consolidação n.5, de 28 de setembro de 2017). Plasma transfusion receptor: respiratory insufficiency with indication for mechanical ventilation; severe sepsis or septic shock; active co-infection with a dengue virus, confirmed by serological detection of the NS1 antigen or RT-PCR; admission to the Intensive Care Unit (ICU); having received intravenous immunoglobulin (IVIG) in the last 30 days; history of allergy or hypersensitivity to a blood product transfusion; heart or renal insufficiencies that makes the excess volume from plasma transfusion not advisable; in women, present pregnancy, plans to get pregnant in the following two months or breastfeeding; be part of another clinical trial.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-7hfd5rc	Clinical Trial: Accelerated Recovery Protocol in Patients Undergoing Bariatric Surgery	Recruiting	Intervention	2022-04-20	<NULL>	<NULL>	5358	Clinical Trial: Accelerated Recovery Protocol in Patients Undergoing Bariatric Surgery. Randomized Comparative Study Between Usual Acceleration Protocols and the One Currently Used in the Institution (SAMSURP)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Casa de Saúde Santa Marcelina	Casa de Saúde Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-7hfd5rc	<NULL>	Patients aged between 18 and 60 years; able to read, understand and sign the consent form; undergoing the first procedure for the treatment of obesity	patients with a BMI above 60 kg/m2; patients with chronic pain with continuous use of medications for pain control, such as fibromyalgia and non-eventual low back pain; patients with heart and coronary diseases; ventricular ejection fraction less than 50%; anticoagulation with warfarin; patients with chronic kidney disease on dialysis; patients with mobility and ambulation difficulties; prolonged surgical time (greater than 3 hours) or need for conversion to open surgery; patients referred to the intensive care unit (ICU) after the procedure; need for drainage of the abdominal cavity; latex allergy; allergy to any of the medications used in the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-10r7d6f3	Clinical, anti-inflammatory and antioxidant effects of fish oil and vitamin D supplementation in sickle cell disease patients: a randomized, blinded, placebo-controlled study	Recruitment completed	Intervention	2021-07-20	<NULL>	<NULL>	4794	Omega-3 and vitamin D supplementation in adults with sickle cell anemia	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2018-01-26	Universidade do Estado do Rio de Janeiro	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-10r7d6f3	<NULL>	Adults with ages ranging from 19 to 59 years of age; Be homozygous for sickle cell anemia - HbS (SS genotype); Possibility of attendance at periodic laboratory visits and examinations; Be lucid and oriented.	Participants who have had blood transfusions in the last 1 month before the first evaluation; Participants who present an episode of disease exacerbation at the time of the first evaluation; Participants who have taken vitamin D and / or omega-3 supplementation for less than 6 months or at the time of the first evaluation; Have not been hospitalized for less than fifteen days; People with other types of hemoglobinopathies; Use of Hydroxyurea; Pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:40
RBR-2bghmh	Clinical, blood, mobility and quality of life evaluation in people with metabolic syndrome after whole body vibration exercise in vibratory platform	Recruiting	Intervention	2016-06-14	<NULL>	<NULL>	890	Clinical, metabolic, functional and quality of life evaluation in people with metabolic syndrome after whole body vibration exercise in oscillating / vibratory platform	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Programa de Pós Graduação em Fisiopatologia Clínica e Experimental	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2bghmh	<NULL>	Outpatients both genders; aging over 40 years; of the &quot;Hospital Universitário Pedro Ernesto&quot; (HUPE); with diagnosis of Metabolic Syndrome according the International Diabetes Federation.	Blood pressure higher than 180 x 110 mmHg; Cardiovascular disease in the last 6 months due to heart attack or stroke; Neurological, muscular or rheumatological disease that limit the movements on the oscillating/vibratory platform; Severe or incapacitant clinical disease; Patients that refuse to sign the Agreement Term to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-7x22bcc	Clinical, microbiological and immunological adjunctive effect of photodinamyc therapy in periodontal maintenance therapy.	Recruitment completed	Intervention	2022-11-07	<NULL>	<NULL>	5708	Clinical, microbiological and immunological adjunctive effect of photodinamyc therapy in residual periodontal pockets in periodontal maintenance therapy: a split-mouth randomized controlled trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Minas Gerais	Universidade de Taubaté	https://ensaiosclinicos.gov.br/rg/RBR-7x22bcc	<NULL>	Present at least one appointment for periodontal maintenance therapy in the 12-month interval; bilateral presence of greater equal 2 interproximal sites with a probing depth greater equal 5 mm; clinical attachment levels greater equal 4mm and presence of bleeding on probing (not same tooth)	Patients who were absent from maintenance therapy for more than 12 months. diabetics; former/ somoking; antibiotic use for any purpose within 3 months prior to entering the study; pregnancy and/or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-578rqds	Clomiphene vs Progesterone in Ovarian Stimulation in Patients with Low Ovarian Response	Recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8559	Clomiphene versus Progesterone in an Ovarian Stimulation Protocol in Patients with Poor Ovarian Response: An Open-Label Randomized Clinical Trial	<NULL>	4, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-21	Hospital de Clínicas de Porto Alegre	<NULL>	<NULL>	<NULL>	Age between 18-45 years; Female gender; Patients undergoing their first PPOS protocol who meet the criteria for POSEIDON group 3 (women &lt;35 years old with low ovarian reserve, AFC&lt;5) or POSEIDON group 4 (women ≥35 years old with low ovarian reserve, AFC&lt;5); Indication for in vitro fertilization or intracytoplasmic sperm injection; Signed informed consent	Chromosomal abnormalities in either partner; Oocyte cryopreservation, oocyte or sperm donation; Endometrioma (≥ 3 cm on imaging); Combined transfer of embryos from different stimulation cycles; Contraindication to the use of progesterone or clomiphene	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:19
RBR-54j3726	Clozapine for Autism Spectrum Disorder patients aged 10 to 18 years with severe behavioral problems that have not responded to previous medications.	Recruiting	Intervention	2022-06-29	<NULL>	<NULL>	5455	Clozapine for the treatment of refractory disruptive behaviors in 10-18 years old patients with Autism Spectrum Disorder: an open-label trial	<NULL>	4, n/a, open	4	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-54j3726	<NULL>	Diagnosis of Autism Spectrum Disorder; boys and girls aged 10 to 18 years; disruptive behaviors with two failures of antipsychotic treatment; Moderate or greater behavioral problems as measured by a Clinical Global Impression Scale—Severity (CGI-S) score of 4 or higher at screening; involvement of a parent or caregiver able to consistently complete assessments throughout the study.	Clinical disease that contraindicates the use of clozapine; history of serious side effects to clozapine; previous treatment failure to the use of clozapine; pregnancy or breastfeeding; absence of psychosocial support considered enough to follow the study protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-33jphr	Co2 LASER and Microablative Fractionated Radiofrequency in treatment of  urinary incontinence. A Randomized Controlled Trial	Recruitment completed	Intervention	2018-07-05	<NULL>	<NULL>	4608	CO2 LASER and Microablative Fractionated Radiofrequency in treatment of urinary incontinence. A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Escola Paulista de Medicina	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-33jphr	<NULL>	Age between 30 and 75 years; main clinical complaint of stress incontinence urinary confirmed by clinical examination; absence of genital prolapse or prolapse stage more than II, where the prolapse reaches the maximum of the himenal ring and point Ba less than or equal to zero; no use of local estrogen therapy for at least 6 months; negative culture of urine; absence of previous surgical treatment of SUI or colpoplasty; absence of predominant urgency symptom; absence of active infection by HPV or genital herpes; absence of abnormal genital bleeding; absence of antecedent of genital neoplasia or current genital neoplasia; absence of Neurogenic Bladder; absence of pregnancy or puerperium	Age below 30 years and above 75 years; presence of genital prolapse grade 2 that exceeds himenal ring, or grades 3 and 4; previous surgical treatment for stress incontinence urinary; overactive bladder; neurogenic bladder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:27
RBR-10np4cyz	CO2 Laser to treat patients diagnosed with Hyperactive Bladder	Recruiting	Intervention	2023-08-29	<NULL>	<NULL>	6400	CO2 Laser treatment on Hyperactive Bladder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Univesidade Federal de São Paulo	Univesidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10np4cyz	<NULL>	Women diagnosed clinically with Overactive Bladder Syndrome; Age between 18 and 80 years; Signature of the consent form; A 3-day voiding diary showing 8 or more voids in 24 hours and at least 1 episode of urinary urgency.	Untreated urinary infection; untreated genital infection; Bladder Pain Syndrome; Neurogenic bladder; Stroke, neurological or neurodegenerative diseases; Genital prolapse of any compartment above the hymenal ring; Urinary tract lithiasis or tumors; Physiotherapeutic or drug treatment for SBH within the past 2 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-2mpn8qk	Coaching leadership development program for nurses	Not yet recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6702	Effectiveness of a program for developing leadership coaching in nurses: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Hospital de Clínicas da UNICAMP	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2mpn8qk	<NULL>	Nurses; minimum age 18 years; both genders; provide direct assistance to the patient; work for at least three months at the institution; not have a temporary contract; not have undergone coaching training or have previously participated in a coaching process	Nurses who do not attend two sessions of the intervention program; professionals who do not respond to the instruments in T7; those who leave more than 50% of the questionnaire responses blank, at any time during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-5qczxhb	Coffee-flavored drink to shorten fasting time before surgery	Recruiting	Intervention	2025-05-13	<NULL>	<NULL>	8000	Instant coffee-flavored product to shorten pre-operative fasting	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Regional Integrada do Alto do Uruguai e das Missões – URI - Campus de Erechim	Universidade Regional Integrada do Alto do Uruguai e das Missões – URI - Campus de Erechim	https://ensaiosclinicos.gov.br/rg/RBR-5qczxhb	<NULL>	Volunteers who agree to participate in the study; aged between 18 and 65 years; of both sexes; undergoing elective surgery regardless of specialty or surgical team	Allergy to any component of the coffee-flavored instant product; pregnant women; individuals with diabetes; gastropathy; or gastroesophageal reflux will be excluded from the second phase of the study as part of the test group; there are no exclusion criteria for the control group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-8bt3hg	Cognitive assessment and patients with multiple sclerosis and their relationship with performance in virtual tasks	Recruiting	Intervention	2020-08-05	<NULL>	<NULL>	4088	Neuropsychological assessment and patients with multiple sclerosis and their relationship with performance in virtual tasks	<NULL>	1-2, non-randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-06-01	EACH - USP	Associação Brasileira de Esclerose Múltipla	https://ensaiosclinicos.gov.br/rg/RBR-8bt3hg	<NULL>	Patients diagnosed with MS undergoing clinical follow-up at the Brazilian Multiple Sclerosis Association; People from the city of São Paulo who do not have MS.	People with MS and without MS with psychiatric illnesses; visual illnesses; fatigue; muscle deformity or weakness in upper limbs; outbreak in the last 2 months; surgery or chemical neuromuscular blockade in the upper limbs in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-85t3hdf	Cognitive Behavioral Intervention in patients with weight regain after Bariatric Surgery: a controlled clinical study in group and online formats	Terminated	Intervention	2025-08-25	<NULL>	<NULL>	8227	Cognitive Behavioral Group and Online intervention for patients with weight regain after Bariatric Surgery: a controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-05	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-85t3hdf	<NULL>	Aged between 30 and 65 years; both sexes; bariatric surgery performed in 2018 at the Hospital das Clínicas, Faculty of Medicine, University of São Paulo (USP); availability to participate in the sessions and assessments; internet access (for the virtual group)	Age under 30 or over 65 years; pregnancy; physical or cognitive impairment preventing participation in the sessions; refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-8qp575b	Cognitive function after robot-assisted laparoscopic prostatectomy: a prospective study	Recruitment completed	Observational	2023-02-08	<NULL>	<NULL>	5885	Assessment of cognitive function in potoperative robot-assisted laparoscopic radical prostatectomy:prospective cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital Brasília	Hospital Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8qp575b	<NULL>	Adult patients (between 50 and 70 years old) admitted to the participating center; undergoing robot-assisted laparoscopic radical prostatectomy surgery; american Society of Anesthesiology (ASA) physical status 1 to 3; body mass index between 18 and 35; education greater than or equal to 5 years; having signed an informed consent; no history of brain disease, dementia or other psychiatric disorders that affect cognition;	Surgeries lasting less than and equal to 1 hour; patient referred to the Intensive Care Unit; severe hearing or visual impairment;legally protected adults (under judicial protection, guardianship or supervision), persons deprived of their liberty;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-58986zm	Cognitive rehabilitation program for patients with long COVID	Not yet recruiting	Intervention	2024-10-11	<NULL>	<NULL>	7424	Characterization of Neuropsychiatric, Neuropsychological, Radiological and Biological Findings of COVID-19 Infection in the Central Nervous System: a Cohort Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-18	Instituto de Psiquiatria da Faculdade de Medicina da Universidade de São Paulo	Núcleo de Inovação Tecnológica – InovaHC	https://ensaiosclinicos.gov.br/rg/RBR-58986zm	<NULL>	Individuals aged 18 or over, with a history of hospitalization due to COVID-19, who present complaints about their cognition demonstrated by performance below expectations in clinical assessments two years after hospital discharge.	Individuals with intellectual disabilities; individuals with severe visual and/or motor difficulties; and participants with less than eight hours of exposure to the game.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3r6pc2	Cognitive stimulation therapy for elderly with cognitive and functional complaints: Brazilian adaptation and validation	Recruiting	Intervention	2017-07-17	<NULL>	<NULL>	1294	Cognitive stimulation therapy for Dementia: Brazilian adaptation and validation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Pontifícia Universidade Católica do Rio de Janeiro	Pontifícia Universidade Católica do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3r6pc2	<NULL>	Age over 60 years; Both genders; People diagnosed with dementia; Score between 10 and 24 on the Mini Mental State Exam; Be able to answer neuropsychological evaluation.	Age greater than 95 years. Mental retardation previously diagnosed according to ICD criteria 10.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-89fbts7	Cognitive Stimulation Therapy for Neurocognitive Disorders in Brazilian Long-Term Care Institutions for the Aged	Recruiting	Intervention	2024-01-09	<NULL>	<NULL>	7830	Implementation of Cognitive Stimulation Therapy for Neurocognitive Disorders in Brazilian Long-Term Care Institutions	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-89fbts7	<NULL>	Older adults living in Long Term Care Facilities for the aged; with mild dementia; or with mild neurocognitive disorder; aged at least 60 years; both sexes	Communication disabilities; moderate to severe dementia; other severe decompensated mental disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-26bhg4z	Cognitive Therapy Based on Mindfulness and Treatment Resistant Depression: A study comparing two groups	Not yet recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5322	Mindfulness-based cognitive therapy and Depression resistant to treatment: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-26bhg4z	<NULL>	Participants aged 18 or over; major depressive disorder according to the DSM-V criteria; a score equal to or greater than 18 points on the Hamilton Depression Scale (HAM-D17)	without diagnosis of major depressive disorder DSM-V criteria; diagnosis of schizophrenia or other psychotic symptoms; meet the DSM-V criteria for alcohol or substance abuse or addiction within 3 months before entering the study; had been practicing meditation or yoga for at least two months; have cognitive impairment (score &lt;22 on the MMSE); are in individual or group psychotherapy and are not willing to discontinue treatment for the duration of 8 weeks of study treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-7chtrj	Cognitive therapy in the treatment of resistant social anxiety disorder	Recruiting	Intervention	2017-09-13	<NULL>	<NULL>	1374	Augmenting pharmacological treatment of treatment-resistant social anxiety disorder with cognitive therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Instituto de Psiquiatria da UFRJ - IPUB	Instituto D'Or	https://ensaiosclinicos.gov.br/rg/RBR-7chtrj	<NULL>	A current principal diagnosis of social anxiety disorder by DSM-5 criteria; A history of at least one unsuccessful adequate pharmacological treatment trials, operationalized as lack of response Clinical Global Impression-improvement scale (CGI-I)  greater than or equal to 3, to at least 10 weeks of (i) SSRIs or venlafaxine at adequate dosage; with or without (ii) benzodiazepines (e.g. clonazepam 2 mg/day); A total score on the Liebowitz Social Anxiety Scale (LSAS) of 50 or greater; Man and woman with age of at least 18 years.	Pregnancy, lactation, and women of childbearing potential without accepted forms of contraception; Psychotic disorders, bipolar disorder, mental retardation, a recent history of alcohol or substance abuse or dependence; Severe organic medical disorder; Concurrent use of other psychotropic medications than detailed in inclusion criteria; Current or recent significant suicidality; Any concurrent psychotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-6p2vsf	Cognitive therapy may improve quality of life in people with acromegaly	Data analysis completed	Intervention	2018-10-01	<NULL>	<NULL>	2251	Think healthy: contributions of cognitive therapy to increase the quality of life in patients with acromegaly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-10	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6p2vsf	<NULL>	The criteria for inclusion in the group are patients with acromegaly in ambulatory follow-up, of both gender, aged between 18 and 70 years, with intellectual capacity to follow the intervention and who agree to participate in the study.	There are criteria for excluding the sample: suicide risk; absence of commitment to the fulfillment of written tasks and being accompanied in therapy. Sample participants shall be considered as sample loss if they are absent, not justified, for two consecutive sessions or for three alternating sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-3bq3gq	Cognitive training workshop for healthy elderly	Recruitment completed	Intervention	2020-07-09	<NULL>	<NULL>	3991	Cognitive training workshop for elderly people without cognitive impairment: an Occupational Therapy intervention	<NULL>	3, non-randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-01-20	Universidade Federal do Paraná	SETOR DE CIÊNCIAS DA SAÚDE DA UNIVERSIDADE FEDERAL DO PARANÁ	https://ensaiosclinicos.gov.br/rg/RBR-3bq3gq	<NULL>	Be 60 years old or more; Do not show signs of cognitive impairment; Do not have a depressive or suspected depression; Have an interest in participating in the cognitive training workshop for the duration of the same; Do not have severe visual impairment without optical correction; Not having severe hearing loss; Be literate.	Subjects who do not meet the inclusion criteria, and do not know how to read and write, as well as people with extreme difficulty in seeing and hearing even with the best correction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-7kh27st	Cognitive-Evolutionary Group Therapy	Not yet recruiting	Intervention	2022-09-29	<NULL>	<NULL>	5641	Efficacy of Cognitive-Evolutionary Group Therapy for Depression: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-7kh27st	<NULL>	Aged at least 18 years old; have mild or moderate depression, expressed as a score of at least 9 to 20 on the Patient Health Questionnaire-9 (PHQ-9), without suicide risk evaluated by the Structured Clinical Interview for DSM-5 (SCID-5); have Internet at home and a computer or any electronic device connected to the Internet in order to access the free platform of Google meet; filled out the mandatory inform consent.	Having hypothyroidism due to being a cause of organic depression related to hormone levels; having suicide risk evaluated by the Structured Clinical Interview for DSM-5 (SCID-5); having severe depression (score &lt; 20 or more on the PHQ-9); having a medical disorder that would interfere to participating; having substance abuse (alcohol and others drugs), psychosis, anxiety or panic disorder out of context of depression, personality disorders (obsessive-compulsive and borderline disorder); bipolar disorder; be under psychological treatment by the time of the recruiting.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-7kzh4p	Cohort study of children born in Campinas and Paulínia-SP	Recruitment completed	Observational	2016-04-07	<NULL>	<NULL>	3225	Cohort study of children born in Campinas and Paulínia-SP	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Centro Infantil Boldrini	Instituto Ronald McDonalds	https://ensaiosclinicos.gov.br/rg/RBR-7kzh4p	<NULL>	"It will be eligible for this study pregnant women in the first trimester of pregnancy, user  of one of the 63 Public  Health Center Services /  Basic Health Unit/SUS located in Campinas City, São Paulo, Brazil.
Additionally, it will be included pregnant women in the first trimester of pregnancy, user of one service among  9 Public Health Centers /  Basic Health UNIT / SUS located in Paulínia City , São Paulo, Brazil"	"Pregnant women in late pregnancy, who did not answered the epidemiological questionnaire and did not participate with the peripheral blood collection.
Pregnant women who do not perform prenatal care in the Public Basic Health Units / SUS located in the Cities of Campinas and Paulinia."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-556dhr	Colchicine to reduce arrhythmia in the postoperative period of cardiac surgery	Recruitment completed	Intervention	2015-05-22	<NULL>	<NULL>	484	Colchicine for reduction of Atrial Fibrillation after coronary artery bypass - randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-05-01	Hospital Santa Casa de Misericórdia de Curitiba	Hospital Santa Casa de Misericórdia de Curitiba	https://ensaiosclinicos.gov.br/rg/RBR-556dhr	<NULL>	Patients were recruited willing and able to provide informed consent and in accordance with the study procedures. All aged greater than or equal to 18 years; indication for elective coronary artery bypass grafting; sinus rhythm on the day preceding surgery. The mean age was 60.3 ± 8.1 years in the control group and 61.5 ± 10.3 years in the colchicine group (p = 0.44), 45 participants were female and 95 male. The sample size was 140 patients	Exclusion criteria were: contraindication for use of study medication; atrial fibrillation or atrial flutter previously diagnosed; need for associated valve surgery; severe liver disease (transaminases above 1.5 times normal); renal failure (creatinine&gt; 2 mg / dl); gastrointestinal diseases known; current treatment with colchicine; cardiogenic shock; severe arrhythmias; neoplasms; patients not communicative; Simultaneous use of antiarrhythmic drugs, excluding digoxin, beta-blockers and calcium channel blockers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-6xpd34	Collaborative approach in clinical simulation	Recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3939	Collaborative approach in clinical simulation: new conduction proposal	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-12	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6xpd34	<NULL>	Being an academic in the undergraduate nursing course at the Federal University of Goiás; have attended or are attending a course in child health.	Absence in the pre or post-test; failure to complete the anxiety-related inventory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-38gcwz9	Collagen Matrix vs. Connective Tissue Graft for peri-implant soft tissue augmentation	Data analysis completed	Intervention	2024-06-24	<NULL>	<NULL>	7091	Stability of subepithelial Connective Tissue Graft or volumetrically stable Collagen Matrix for ridge volume augmentation: split-mouth randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	FAESA-Centro Universitário Espíritosantense	FAESA-Centro Universitário Espíritosantense	https://ensaiosclinicos.gov.br/rg/RBR-38gcwz9	<NULL>	Good oral hygiene with visible plaque index less than 20%; age higher or equal to 18 years; both genders; sufficient tissue availability to harvest an autogenous soft tissue graft from the palate with 12 mm width, 8 mm height, and 2 mm of thickness; soft tissue at the implant site with a thickness inferior to 2 mm; an implant installed for at least 3 months in both sides of the posterior mandible; need for reopening procedure in the implants	Systemic alterations; presence of inflammation or infection involving the regions where the surgical procedures were performed; bone pathology in the implant site; smoking; excessive use of alcohol; drug addiction; diabetes; pregnancy or desire to become pregnant in the next year; history of radiotherapy treatment in the head and neck region, and people who take medications that may interfere with bone remodeling or who have pathologies that affect bone metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-62nn2w4	Color evaluation of different aesthetic elastics submitted to mouthwash with and without alcohol.	Recruitment completed	Intervention	2021-12-15	<NULL>	<NULL>	5114	Color evaluation of different aesthetic orthodontic ligatures submitted to mouthwashes with and without alcohol.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Fundação Hermínio Ometto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-62nn2w4	<NULL>	Volunteers undergoing orthodontic treatment who have conventional orthodontic appliance with rubber band ligation; Patients with good oral hygiene; At least five teeth present in each arch.	Patients who have self-ligating devices; periodontal problems; patients with systemic diseases or cleft lip and palate; use of medications (antibiotics or anti-inflammatory drugs up to 30 days before the study); smoker or ex-smoker; pregnant or breastfeeding; patients allergic to the components of the mouthwash formula.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-99b93yh	Color match of fluid restoration placed close to the gums before and after in-office whitening	Recruiting	Intervention	2025-02-18	<NULL>	<NULL>	7761	Color matching of unichromatic flowable composite resin before and after in-office bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-99b93yh	<NULL>	Men and women; Good general health; good oral hygiene; present at least 20 teeth under occlusion; at least two non-carious cervical lesions comparable in size; shape and dimensions; non-retentive; deeper than half a mm; and involve both the enamel and dentin of vital teeth; the cavosurface margin cannot involve more than 50% of the enamel; never having undergone dental whitening	Higiene oral extremamente pobre; usando dispositivos ortodônticos; periodontite severa ou crônica; hábitos de bruxismo pesado; alergia conhecida a materiais à base de resinas ou qualquer outro material usado neste estudo; mulheres grávidas ou lactantes; uso crônico de drogas anti-inflamatórias; analgésicas e psicotrópicas; paciente que já realizou clareamento dental	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-83dk7z	Colostrum administration in very low birth weight preterm infants - clinical trial	Recruiting	Intervention	2017-01-25	<NULL>	<NULL>	1182	Oral immunotherapy in very low birth weight preterm infants - randomized double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Hospital Moinhos de Vento	Faculdade de Medicina da Pontífice Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-83dk7z	<NULL>	Premature inborn at Hospital Moinhos de Vento; with birth weight equal to or below 1500 grams; and/or gestational age equal to or less than 30 weeks; admitted to the NICU.	Malformations incompatible with life; malformation of the gastrointestinal tract; contraindication to breast milk; death in the first 6 days of life.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-25rc6q	Colour durability of Resin Cement Activated by Light and Double-Activated	Recruitment completed	Intervention	2015-04-06	<NULL>	<NULL>	1083	Colour stability of Photoactivated and Dual Resin Cement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Universidade Federal de Santa Maria - UFSM	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-25rc6q	<NULL>	Volunteers of both genres; age between 20 and 45 years; with good general and oral health; absence of orthodontic appliance; absence of posterior crossbite; absence of noncarious cervical lesions; upper second premolars vital and without restorations; upper second premolars with colour homogeneity in relation to adjacente teeth; areas of buccal surface that circumscribe a circle with minimum diameter of 6 mm	Individuals with gingival recession on buccal surface of upper second premolars; dental sensibility to air blast; enamel or dentin defects; tetracycline staining; unilateral or bilateral crossbite; mandibular prognathism; maxillary retrognathism; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-549sw73	Colprecardio: Local capacities for the prevention of cardiovascular disease in Colombia	Recruiting	Intervention	2026-04-10	<NULL>	<NULL>	9082	Colprecardio: Strengthening the capacity of municipal health secretariats (MHS) for the prevention of cardiovascular disease (CVD) in Colombia	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-25	Escola de Governo, Universidade dos Andes	<NULL>	<NULL>	<NULL>	The trainers will be professionals from the departmental and municipal health secretariats or their equivalents in the indigenous communities of Cauca Colombia; with training in health or social sciences and at least six months of experience in public health; they must have basic oral and written communication skills; as well as minimal technological skills for using computers; their selection is not random; participants must demonstrate an explicit interest in participating in accordance with a commitment agreement that stipulates the requirements rights and obligations of participation and have the minimum required internet connectivity. In the case of the Local Cardiovascular Disease Prevention Teams (ELPEC); will be comprised of teams of professionals; technicians; and technologists from the municipal health secretariats of Cauca Colombia responsible for developing interventions for the prevention of cardiovascular disease in their territories	Regarding the trainers; inability to guarantee sustained participation during training and associated activities; imminent or confirmed change of duties or position that prevents fulfilling the role of trainer during the implementation period; limitations that prevent the effective use of the tools required for the virtual component; non-acceptance or withdrawal of consent or non-signing of the participation commitment and simultaneous participation in an equivalent training process that may interfere with the attribution of changes evaluated in the study. In the case of the Local Cardiovascular Disease Prevention Teams (ELPEC); withdrawal or lack of institutional political will to participate during the implementation period; lack of real and sustained minimum connectivity to develop the virtual component and monitoring instruments; inability to form or maintain an operational Local Cardiovascular Disease Prevention Teams (ELPEC) during the intervention; security conditions or logistical barriers that prevent the safe and reasonable execution of the planned activities; Inability to provide the minimum information required for measurements and monitoring within the established timeframes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-10vj22fr	Combination of Laser Therapy and Phytotherapy for the Treatment of Menopausal Symptoms	Recruitment completed	Intervention	2025-06-18	<NULL>	<NULL>	8060	The use of standardized extracts of Angelica keiskei and Panax ginseng as a strategy to potentiate the biological effects induced by red laser on postmenopausal symptoms	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-05-05	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-10vj22fr	<NULL>	Women between 40 and 65 years of age; experiencing amenorrhea for at least 12 months due to natural causes or due to health treatment; characterizing the post-menopausal period	Participants who do not sign the informed consent form; women who have received hormone therapy in the last 6 months; with untreated hypothyroidism; any type of cancer; photosensitivity; cardiac arrhythmias; pacemaker wearers; presence of neurological; renal; hepatic diseases or infectious disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-4pt72m	Combination of physical exercises and training in video games for post stroke people	Recruiting	Observational	2017-01-24	<NULL>	<NULL>	1987	Combination of multimodal physical exercises in real and virtual environments for individuals after chronic stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-15	Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4pt72m	<NULL>	Chronic phase stroke; territory of the Cerebral Media or in the Anterior Cerebral Artery; both types of stroke (ischemic and hemorrhagic); cognition greater than 24 points in the Mini Mental State Examination; to less than 2 months of use in forms and the Wings of Empowerment with physical exercises; (community) and without experience in Virtual Reality games.	Individuals with any type of cardiovascular complication that would contraindicate physical exercise; who underwent surgeries to attenuate clinical conditions resulting from stroke; that had a chemical blockade to reduce spasticity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-7hk8n3	Combination of reduced doses of naltrexone and cranial electrical stimulation in fibromyalgia: randomized clinical trial, blind, controlled with placebo	Recruiting	Intervention	2019-01-08	<NULL>	<NULL>	2430	Association of low doses of Naltrexone and Transcranial Electrical Stimulation in Fibromyalgia: randomized clinical trial, blind, controlled with placebo	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade La Salle	Universidade La Salle	https://ensaiosclinicos.gov.br/rg/RBR-7hk8n3	<NULL>	Provide an informed consent to participate on the study; women with age between 18 and 65 years; medical diagnoses of fibromyalgia according to the American College of Rheumatology criterion (2010); know how to read and write; pain evaluated as bigger than six at the last 3 months on the Visual Analogic Scale; treatment of chronic use stable on the last 3 months;	Be using opioid drugs; pregnancy or non-use of contraceptive method; history of alcohol or drugs abuse on the last 6 months; historic of neurologic pathology; history of cardiac arrhythmia and use of drugs that change the vascular answer (adrenergic blockers, vasodilators); history of cranial traumatism moderated or severe; history of neurosurgery; systemic decompensated disease, and chronic inflammatory disease (Lupus, rheumatoid arthritis, Sjogren Syndrome, Reiter Syndrome);  history of hypothyroidism non compensated; personal history of cancer, passed or in treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-7h834x	Combined BCAA and Omega 3 Supplementation: Clinical-Nutritional, Cardiorespiratory, Metabolic Impact and Quality of Life in Pre-Malnourished / Malnourished Patients	Not yet recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3412	Combined supplementation of Ramified Chain and Omega 3 Amino Acids: clinical-nutritional, cardiorespiratory, metabolic impact and quality of life in pre-cachectic / cachectic patients	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Maranhão	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão - FAPEMA	https://ensaiosclinicos.gov.br/rg/RBR-7h834x	<NULL>	Uterine Cervical Cancer; Minimum age of 20 years; Stability (no changes in treatment regimen within 6 weeks or hospitalizations within 3 months); Sign the consent form.	Restricted Vegetarian; Use of pacemaker; Palliative care; Withdrawal of Consent; Accession to intervention below 75%; Allergy Nutritional Composition of Supplements; Refusal of the proposed supplementation; Significant worsening after intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-3w59nw	Combined effect of plyometric training with strength training with different rests on the performance of the jump space	Recruitment completed	Intervention	2018-10-02	<NULL>	<NULL>	2255	Combined effect of plyometric training with strength training in different densities on the performance of the ejambeé jump	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-27	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3w59nw	<NULL>	Be a competitor of regular competitive rhythmic gymnastics training for at least two years;participate in gymnastics training at least 3x a week; be between the ages of 13 and 15; be willing to participate in all tests and training sessions; not injury or illness that prevents the physical proposed exercise described in this document	Failure to attend any of the proposed tests; failure to attend 25% or more of the training sessions; suffer any type of injury that prevents participation in the proposed tests or continuation of the training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-7w3jw35	Combined Electrical Stimulation of the Brain and Muscles for patients with Spinal Cord Injury: an experimental study	Recruitment completed	Intervention	2024-03-05	<NULL>	<NULL>	6826	Transcranial Electrical Stimulation combined with Neuromuscular Electrical Stimulation in patients with Spinal Cord Injury: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7w3jw35	<NULL>	Spinal cord injury at any neurological level from C2 to T12 for at least one year. Stable neurological deficit for at least 6 months. Over 18 years of age. Both sexes. Pain at the neurological level of injury or below with a Neuropathic Pain 4 (DN4) scale equal to or greater than 4	Cognitive impairment that prevents the safe completion of electrode training. Neuropathic pain prior to spinal cord injury. Other chronic pain syndromes, especially fibromyalgia and complex regional pain syndrome. Extensive skin lesions that do not allow electrode coupling. Decompensated mood disorder. Epilepsy. Use of a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:58
RBR-5z5h789	Combined Functional Exercises with Mindfulness for improve physical and cognitive function in Older Adults with Slow Gait Speed and Cognitive Complaints	Not yet recruiting	Intervention	2022-02-22	<NULL>	<NULL>	5239	Optimizing the body-mind interaction through combining Functional Exercises and Mindfulness: effects on physical and cognitive function of Seniors with Motoric Cognitive Risk Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Universidade de Pernambuco - UPE (Campus Petrolina)	Universidade de Pernambuco - UPE (Campus Petrolina)	https://ensaiosclinicos.gov.br/rg/RBR-5z5h789	<NULL>	We will recruit older adults, 65 years and older, with MOTORIC Cognitive Risk Syndrome	We will exclude participants who have the following criteria. not being able to speak and understand the Portuguese; not being able to walk at least 10 meters without mobility aids (eg, cane); participate in structured physical exercise programs for at least 3 months; have exacerbated walking impairment due to  musculoskeletal disorders or neurological motor deficit (eg, severe osteoarthritis, lower limb amputation, Parkinson&apos;s disease, stroke with motor sequelae); use antipsychotic-type drugs, have a diagnosis of major depression or any-type dementia;  have unstable cardiovascular or metabolic diseases (eg, angina pectoris, decompensated diabetes) or chronic complications (eg, retinopathy, neuropathy) that precludes structure exercise engagement; not having adequate visual and auditory capacity to perform the cognitive assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-2tstxd	Combined treatment with conventional chemotherapy and green tea capsules for elderly acute myeloid leukemia patients	Recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2286	Green tea as immunomodulation and antineoplastic therapy for elderly Acute Myeloid Leukemia unfit for high dose conventional chemotherapy	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2013-10-01	Hemocentro - Universidade Estadual de Campinas	Hemocentro - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2tstxd	<NULL>	Patients with AML according 2016 WHO classification, including de novo and secondary AML; age over 60 years; Eastern Cooperative Oncology Group (ECOG) performance status 0-3; informed consent, personally signed (or legal responsible person) and dated to participate in the study; be able to comply with study procedures and follow-up examinations; last chemotherapy regimen at least 60 days ago. Hydroxiurea use is allowed.	Psychiatric disorders that would interfere with consent, study participation, or follow-up; chronically impaired renal function (creatinine clearance &lt; 30 ml / min); inadequate liver function (ALT and AST over 2.5 x ULN) if not caused by leukemic infiltration; total bilirubin over 1.5 x ULN if not caused by leukemic infiltration; known HIV and/or hepatitis C infection; diagnosis of another malignancy, unless the patient has been disease-free for at least 5 years following the completion of curative intent therapy with the following exceptions: Patients with treated non-melanoma skin cancer, in situ carcinoma, or cervical intraepithelial neoplasia, regardless of the disease-free duration, are eligible for this study if definitive treatment for the condition has been completed. Patients with organ-confined prostate cancer with no evidence of recurrent or progressive disease based on prostate-specific antigen (PSA) values are also eligible for this study if hormonal therapy has been initiated or a radical prostatectomy has been performed; history of organ allograft; patients who have an indication for and can undergo a non-myeloablative transplant procedure; cardiac Disease: Heart failure NYHA class 3 or 4; unstable coronary artery disease (MI more than 6 months prior to study entry is permitted); serious cardiac ventricular arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-8vny3v	Combined use of body movements with laser light for the stimulation of nerves and muscles on the face	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4049	Different Kinesiotherapies associated with Biophotonics for Neuro-facial muscular Reprograming	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	University of São Paulo, São Carlos Physics Institute, Department of Optics and Biophotonics	University of São Paulo, São Carlos Physics Institute, Department of Optics and Biophotonics	https://ensaiosclinicos.gov.br/rg/RBR-8vny3v	<NULL>	Healthy females; ages between 35 and 55 years; no history of systemic diseases such as hypertension, diabetes or heart diseases	Presence of uncontrolled systemic diseases; pregnant women; breast feeding women; presence of oral tumors; presence of temporomandibular joint disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-33mjbg	Combined use of Propolis with Antiretroviral Therapy and possible health benefits of HIV-infected individuals	Not yet recruiting	Intervention	2018-05-09	<NULL>	<NULL>	1773	Association of Propolis to Antiretroviral Therapy for HIV-infected individuals: innovation in treatment and possible benefits in immunological, inflammatory and oxidative stress parameters	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Instituto de Biociências de Botucatu - UNESP	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-33mjbg	<NULL>	To have confirmed HIV infection and use of cART with adequate viral suppression for at least three years; have a minimum age of 20 and a maximum of 50, and sign a Consent Form.	cART patients for more than 10 years and / or under rescue therapy; vertical transmission; patients with cancer, diabetes mellitus, cardiovascular or autoimmune diseases; transplanted; patients who exercise regularly; pregnant or lactating women; presence of co-infections such as tuberculosis, viral hepatitis, toxoplasmosis, among others; genetic diseases; treatment with anxiolytics or antidepressants; vitamin supplementation; users of illicit drugs, active smokers and alcoholics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-967thyx	Combining Brain Stimulation and Reading Therapy to Help People with Dyslexia	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8555	Association of Transcranial Direct Current Stimulation with Multilevel Reading Therapy for Rehabilitation in Dyslexia: Procedures Protocol and Clinical, Controlled, Randomized, Double-blind Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Escola Paulista de Medicina - Universidade Federal de São Paulo (UNIFESP)	<NULL>	<NULL>	<NULL>	Children of both sexes; aged 9 to 12 years; with a multidisciplinary diagnosis of Developmental Dyslexia; from outpatient clinics of the Hospital São Paulo, Paulista School of Medicine of the Federal University of São Paulo	Uncorrected auditory sensory deficits; uncorrected visual sensory deficits; epilepsy; metallic implant in the skull or hearing aids	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:15
RBR-2zky4p9	Comfort and safety of an adapted mask versus an orofacial mask in postoperative heart surgery patients	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5177	Comfort and safety of the owner mask in relation to the conventional orofacial mask in post-operative heart surgery patients: a pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-03	Universidade de Santa Cruz do Sul	Hospital Santa Cruz	https://ensaiosclinicos.gov.br/rg/RBR-2zky4p9	<NULL>	"Patients admitted to the ICU for post-operative care after CABG or TV from May to October 2021.
Patients of both sexes.
Age between 18 and 80 years.
Indication of institution of non-invasive ventilation after extubation.
Preserved cognitive ability to understand the proposed tests."	"Comatose patients (Glasgow Coma Scale &lt;8).
Patients who refuse to receive non-invasive ventilation.
Presence of facial anomalies, facial trauma and facial burns.
Presentation of vomiting and severe hematemesis.
Massive hemoptysis.
Hemodynamically unstable patients
Mental confusion.
Patients who do not sign the Informed Consent Form (FICF)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-3gj96xw	Comfort and usability of customized mouthguards obtained by conventional molding and through an intraoral scanner and 3D printers: randomized clinical trial	Recruitment completed	Intervention	2025-03-17	<NULL>	<NULL>	7840	Comfort and usability of personalized mouthguards obtained by conventional and digital flow impressions: a randomized, parallel-arm clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade de Odontologia Universidade Federal de Uberlândia	Hospital Odontológico da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3gj96xw	<NULL>	Young and adult athletes of both genders; over 16 years of age; with sufficient critical ability to answer the questionnaire objectively; who regularly practice some sport at least twice a week and who agree to use a mouthguard in all sports activities; patient who has a medical history that does not compromise the evolution of results; who has the habit of brushing their teeth at least twice a day; who has posterior occlusal stability and who has a normal periodontal condition according to probing parameters	Athletes of both genders; who have recently suffered a dentoalveolar trauma and are in pain; who have a recent root, alveolar or condylar fracture; who need dental retention; who have some chronic disease with oral manifestations; who have some oral pathology considered serious; patients with very poor oral hygiene; patients with occlusal instability; patients with advanced periodontal disease; patients with allergies to any material that will be used at work	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-5t8k6qz	Comic Books and the impact on adolescents&apos; Knowledge and Skills in Basic Life Support: a randomized controlled trial	Not yet recruiting	Intervention	2024-10-03	<NULL>	<NULL>	7397	Effectiveness of Comic Stories on the Knowledge and Skills of adolescents about Basic Life Support: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-04	Universidade Federal do PIauí	Universidade Federal do PIauí	https://ensaiosclinicos.gov.br/rg/RBR-5t8k6qz	<NULL>	Being a teenager; both genders; aged 10 to 19 years old	have professional training in the health area; have completed a Basic Life Support (BLS) course (less than 1 year ago); be expected to be away from work during the data collection period; have participated in the construction and validation stage of the Comic Book (HQ); have a self-reported limitation that makes it impossible to participate in the lecture class, in reading the Comic Book HQ or in developing Basic Life Support maneuvers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-722vgv8	Comics for health education of schoolchildren	Not yet recruiting	Intervention	2024-08-08	<NULL>	<NULL>	8271	Construction and validation of a comic book for health education for schoolchildren	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2026-08-02	Programa de Pós-Graduação em Saúde Coletiva da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-722vgv8	<NULL>	School children enrolled in the 2nd to 5th grade of elementary school; aged between 7 and 10 years old; both genders	School children who have any limitation that prevents participation in intervention activities; or any severe metabolic alteration that requires the use of medications or specific dietary treatment that alters metabolism. In the event of the development of any of the exclusion criteria during the study, the child will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-8j9f586	Community health worker-centered Intervention for Diabetes management in Amazonas: study protocol	Recruitment completed	Intervention	2025-09-08	<NULL>	<NULL>	8262	Intervention led by community health agents for the management of type 2 Diabetes in the interior of Amazonas	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8j9f586	<NULL>	Individuals residing in Iranduba diagnosed with type 2 diabetes mellitus. Male or female. Age 18 or older. Be registered with Primary Health Care (APS) and be accompanied by a Community Health Agent (ACS). Permanent residence in Iranduba for at least 6 months	Acute or chronic disabling illness. Pregnancy at the time of recruitment. Other serious medical conditions that may prevent participation. Acute, terminal illness or serious mental disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-5nf6wd	Community Intervention for elderly with Depression	Data analysis completed	Intervention	2018-09-26	<NULL>	<NULL>	2241	Evaluation of the feasibility of a cluter randomized controlled  trial for the Management of Depression in elderly people living in socioeconomically disadvantaged areas of São Paulo, Brazil: a pilot study	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Faculdade de Medicina da Universidade de São Paulo	King's College	https://ensaiosclinicos.gov.br/rg/RBR-5nf6wd	<NULL>	Individuals aged 60 years and over, enrolled in two Basic Health Units with Family Health Strategy in the municipality of São Paulo; depression assessed with the Patient Health Questionnaire-9 (score 10 or more no PHQ-9).	Complete deafness; terminal illness; risk of suicide; or an inability to communicate (e.g., due to cognitive impairment either reported by a family member or detected by the researcher).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-6r8qgjp	Community-based multicomponent intervention for preventing alcohol use among teenagers	Recruiting	Intervention	2024-08-10	<NULL>	<NULL>	7201	Reduction of alcohol use among teenagers through a community-based multicomponent intervention: an implementation research approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6r8qgjp	<NULL>	Youth aged 10-18; families with one adult  (no age limit) and one teenager aged 10-14 who wish to participate in the program; there is no gender criteria	Young people who are not in the target age group; adults who do not have teenage children or who do not live in the cities agreed for the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-5pckbhj	Comparasion between Micropulse Ciclophotocoagulation and Slowcoagulation technics	Recruiting	Intervention	2023-12-15	<NULL>	<NULL>	6661	Micropulse Ciclophotocoagulation X Slow Coagulation : a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital de Clinicas da Universidade Estadual de Campinas	Hospital de Clinicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5pckbhj	<NULL>	Patients followed at the Glaucoma Service of the Hospital das Clínicas da Universidade Estadual de Campinas UNICAMP with refractory Glaucoma; who have no indication for filtering surgery or who refused to undergo an incisional procedure; having corrected visual acuity equal to or worse than 20/60, Intraocular Pression IOP &gt; 21 mmHg; age &gt; 18 years; both genders	Patients with Glaucoma secondary to uveitis; previous history of cystoid macular edema; ongoing ocular infection; or who have already undergone cyclophotocoagulation or cyclocryotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-888t7r	Comparation between Elixir Sanative® and Chlorexidine mouthwash in cicatrization after tooth extractions	Data analysis completed	Intervention	2020-07-02	<NULL>	<NULL>	3970	Comparative study of Elixir Sanative® and Chlorexidine in alveolar cicatrization	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2015-06-10	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-888t7r	<NULL>	healthy patients; with an indication for tooth extraction contralateral without the requirement for osteotomy or odontosection.	"patients with pathologies
systemic diseases; smokers; alcoholics;pregnant women; patients allergic to one or more drugs used and patients who used anti-inflammatory
or antibiotic in the last 07 days."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-9xyvcyn	Comparation between Passiflora Incarnata X Valeriana Officinalis for conscious sedation in extration of the wisdom teeth surgery	Data analysis completed	Intervention	2025-09-11	<NULL>	<NULL>	8272	Evaluation of the actions of Passiflora Incarnata X Valeriana Officinalis for conscious sedation in anxious patients subjected to mandibular third molar extraction - a prospective, double-blind, split-mouth, and randomized study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-07-01	Centro de Ciências da Saúde da Universidade Estadual de Maringá	Departamento de Odontologia da Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-9xyvcyn	<NULL>	ASA I and II physical classification from the American Society of Anesthesiologists; individuals aged 17 years or older; both sexes; asymptomatic bilateral impacted mandibular third molars in similar surgical positions; patients anxious about undergoing the procedure	Patients taking antidepressant and anxiolytic drugs; History of severe respiratory deficiency, obstructive sleep apnea, alcoholism, narrow-angle glaucoma, myasthenia gravis, congestive heart failure, liver and/or kidney problems, and the use of other depressant drugs; Pregnancy and/or lactation; History of local infections, such as pericoronitis; Hypersensitivity to any component of medications, substances, or materials used in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-858qxn	Comparation between the techniques of Extubation in the Surgical Block and the Intensive Care Unit on the regional lung ventilation assessed by Electric Impedance Tomography in patients undergoing Noninvasive Ventilation following  Heart Surgery: a cross-sectional study	Recruiting	Observational	2018-05-30	<NULL>	<NULL>	1861	Comparation of Ultra-Fast-Track and Fast-Track techniques in the regional lung ventilation assessed by Electrical Impedance Tomography in patient undergoing prophylactic nasal positve airway pressure following Cardiac Surgery: a cross-sectional study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-04	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-858qxn	<NULL>	Ages between 18 and 65 years; body mass index  between 18.5 and 30 kgm2; undergo the Ultra Fast Track and Fast Track extubation techniques; without chronic obstructive pulmonary disease; pulmonary fibrosis; or chronic renal failure; or associated neuromuscular diseases; and those who have an American Society of Anesthesiologists perioperative risk score of less than 4.	Liver failure; congestive heart failure; dementia and Alsheimer&apos;s disease; left ventricular ejection fraction less than 40%; anticonvulsant; antidepressant; psychoactive drug in use and emergency reoperated patients; high surgical risk according to EuroSCORE II; presente cardiopulmonary bypass time great than 120 minutes; bleeding with thoracic drainage great than 100 mLh; renal failure with urine output less than 0.5 mLh in the first 6 hours; increased serum creatinine level less than 50% the baseline; prolonged inotropic and vasodilatory drugs support due to cardiac problems; extubation failure for hypercapnia; more than a failure in the autonomic test; mechanic ventilation assist time greater than 6 hours; hemodynamic instability; cardiogenic shock; severe hypotension with systolic blood pressure less than 90 mmHg; episode abdominal distress; nausea and vomiting; depressed level of consciousness; use of accessory muscle; respiratory rate great than 35 ipm; hypoxemia with PaO2 less than 50 mmHg with FiO2 of 50% or hypercapnia with PaCO2 great than 55 mmHg and with pH less than 7.30.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-3ss6zt	Comparation of Physiotherapu Approach Using Weights and Elastic Bands on Respiratory Function	Recruiting	Intervention	2013-08-21	<NULL>	<NULL>	233	Comparation of Proprioceptive Neuromuscular Facilitation with Resistive Exercise of Fixed Load and Elastic Load on Respiratory Function	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-02	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3ss6zt	<NULL>	Normotensive, aged 18-25 years, not smoking, right-handed according to the Inventory of the Edinburgh Handedness, sedentary.	Underweight and obese according to body mass index, heart disease, lung disease, musculoskeletal disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-5dsrhv	Comparation of treatments of temporomandibular joint problems	Data analysis completed	Intervention	2018-05-18	<NULL>	<NULL>	1814	Comparative study of temporomandibular disfunction therapies: randomized blind controled clinical trials	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Odontologia da Universidade Federal do Ceará	Faculdade de Odontologia da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5dsrhv	<NULL>	Female gender; age between 18 and 59 years; diagnosis temporomandibular dysfunction; adequate bilateral occlusal contacts between molars and premolars; history of orofacial pain, at least during the last 6 months; absence of previous treatment for pain; pain intensity equal to or greater than 7 on a visual analogue scale from 0 to 10; good receptivity and understanding of spoken Portuguese; ability to provide free and informed consent; and availability for attendance to evaluation returns	Abuse of alcohol or illicit drugs; use of antidepressant or antipsychotic medications in the three months prior to the survey; hypersensitivity to the drugs proposed in the research; history of rheumatic or vascular disease; neurological disorders or any systemic base disorders; patients with motor or mental disorders; pregnant women, and patients who suffered some type of macro or microtrauma on the face	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-10vz8y25	Comparative analysis between removable partial dentures with metal and polymeric structures: a randomized controlled and crossover clinical study	Recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4934	Comparative analysis between removable partial dentures with chromium-cobalt and PEEK structures: a randomized  and crossover clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-06	Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo (FORP-USP)	Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo (FORP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-10vz8y25	<NULL>	Patients with total edentulism in the superior arch and partially edentulism in the inferior arch with class I of Kennedy; Patients in between 30 and 60 years olds; Inter-maxillary relationship class I; Low and moderate ridge resorption;	Poor oral hygiene; dental mobility; Periodontal diseases; Inter-maxillary relationships I &amp; II; Smoker; diabetic patients; history of chemotherapy; Psychiatric disorders; xerostomia; oral diseases; allergic reactions to metal and/or polymers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-9w9m83	Comparative analysis in implant-supported metal ceramic and hibrid ceramic crown	Recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1873	"Comparative analysis of Clinical and Molecular parameters in implant-supported Metal Ceramic and 
Hybrid Ceramic crowns"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-9w9m83	<NULL>	Edentulous sites for replacement of unitary prostheses in the premolar or molar regions; bone height at least 8.5 mm; minimum cervical bone thickness of 5 mm; minimum age of 18 years; ASA I or ASA II patients; periodontally healthy adjacent teeth without previous treatment of chronic / aggressive periodontal disease and without the need for prosthetic restoration; healthy natural antagonist teeth (absence of restorations or prostheses) and periodontally healthy.	History of alcoholism; smokers; illicit drug users; cardiopathy; decompensated diabetics; complex rehabilitation needs (alteration of vertical dimension of occlusion, need for other rehabilitation procedures); lack of height and sufficient bone thickness; patients with parafunctional habits (bruxism); grafted areas;  irradiated patients; patients who underwent long-term steroid therapy or bisphosphonate users; periodontally compromised patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-8w8yh8	Comparative analysis of anti-inflammatory effect of two drugs administered previously surgery to remove wisdom teeth	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1386	Comparative analysis of anti-inflammatory effect of a corticosteroid and a NSAID administered previously to impacted thrid molars surgery: a randomized double-blind clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-04-17	Universidade de Pernambuco, Campus Arcoverde	Universidade de Pernambuco, Campus Arcoverde	https://ensaiosclinicos.gov.br/rg/RBR-8w8yh8	<NULL>	Individuals of both sexes; Aging between 18 e 35 years in the moment of the intervetion; Have indication for surgical removal of  four third molars with total or parcial bony impaction; Have the right and left third molars in similar position according to Pell and Gregory and Winter classifications; Be at least 10 days without using any drug that influences significantly the inflammatory response; and agree with the terms of the research.	Have any disease or systemic condition that contraindicate the surgical procedure; Continually use drugs that influences significantly the inflammatory response; Be in gestation or lactation; Show signals and symptons of inflammation or infection related to third molars at the moment of the intervention; Total duration of the surgical procedure longer than 90 minutes in any of the interventions; Have, during the surgical procedure, any unusual complication that results in the break of the protocol estabilished in the material and methods of the study; and refuse to participate of the data collection procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-2qpsxw	Comparative analysis of the single photon diagnostic  tecnology (Spect/CT), with radiopharmaceutical application of Ecdg-99mTc , and computed tomography (CT)- in patients with Lung Cancer.	Not yet recruiting	Intervention	2016-01-28	<NULL>	<NULL>	696	A phase III study comparing the accuracy of Ecdg 99mTc SPECT/CT against CT for the diagnosis and staging of subjects with clinical and radiological  evidence  consistent with a diagnosis of lung cancer	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2015-10-15	Esho Empresa de serviços hospitalares S.A. – Hospital Pasteur	CCTECH Tecnologia em Imagem Molecular Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2qpsxw	<NULL>	Male or female subject with at least 18 years of age.  Women may not be pregnant or breast-feeding, and, for those in post-menopausal, the minimum period shall be 12 months for natural process, or 6 months in surgical cases. Agree to adhere to one of the birth control methods (contraceptives) as proposed protocol. Have evidence of lung cancer or CT study results consistent with a diagnosis of lung cancer. Not be receiving cancer treatment (surgery, radiotherapy and / or chemotherapy) or if the person has had lung cancer in the past, all previous therapy should have completed at least 3 months prior to the inclusion in the study. Must have a score in the instrument Eastern Cooperative Oncology Group (ECOG) less than or equal to 2. Present satisfactory laboratory values (l alanine aminotransferase less than or equal to 2.5 x ULN,  aspartate aminotransferase less than or equal  to 2.5 x ULN; less than or equal  to 2.5 x ULN; bilirubin less than or equal to 2.0 x ULN)	If there are any clinically relevant safety concerns (laboratory, ECG, physical examination, other) which, in the opinion of the investigator, put the subject in unnecessary risk if the subject were to participate. If, in the last 3 months, the patient has been submitted to any treatment for Cancer (radiation therapy, surgery or chemotherapy). Diabetic patient with insulin dependency. Weight limit higher than recommended by SPECT / CT and CT table. Known hypersensitivity to ECDG or contrast, or other compound, including any of the inactive ingredients. Pregnancy or suspected pregnancy, lactation, or planned pregnancy (male and female partners). Clinically significant mental illness that compromises the conduct of the study (which should be determined by the investigator).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-64cw3x	Comparative analysis of the strength of the muscles of the vagina in women who know and do not know about the genital region	Recruitment completed	Intervention	2014-06-24	<NULL>	<NULL>	305	Comparative analysis of the function of the pelvic floor muscles in women with and without knowledge about genital anatomy	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2010-09-01	Raquel Henriques Jácomo	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-64cw3x	<NULL>	Women amenorrheic for at least 12 months	Dyspareunia; latex allergy; narrow vaginal opening; history of neurological disorders, severe obesity, signs and symptoms of urinary tract infection or vaginal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-9wqbx9	Comparative analysis of two solutions for miocardial protection in the correction of congenital cardiopathies.	Data analysis completed	Intervention	2018-07-26	<NULL>	<NULL>	2062	Comparative analysis of myocardial protection with HTK solution and hypothermic hyperkalemic blood solution in the correction of acyanogenic congenital cardiopathies – a randomized study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes	Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-9wqbx9	<NULL>	Children with acyanotic congenital cardiopathies submitted to corrective surgery with extracorporeal circulation and aortic clamping and volunteers to participate in the study.	Children operated for correction of atrial septal defect exclusively, reoperations, palliative surgeries, emergency surgeries, negative in participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-2gj78z9	Comparative clinical study between treatment with papain gel 2% and 10% in patients with lower limb ulcers.	Data analysis completed	Intervention	2022-07-06	<NULL>	<NULL>	5467	Randomized double blind clinical trial, comparing treatment with papain gel 2% and 10% in patients with lower limb ulcers.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-08-29	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2gj78z9	<NULL>	Patients with lower limb ulcers; aged 18 or over; male or female; who agreed to participate voluntarily in the research	Patients under 18 years old; with ulcers with malignant transformation (cancer); arterial disease; osteomyelitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-9bsf32r	Comparative clinical trial between intra-articular corticosteroid infiltration or microfragmented adipose tissue in knee osteoarthritis	Recruiting	Intervention	2022-04-27	<NULL>	<NULL>	5367	Randomized, triple-blind, controlled study to evaluate the efficacy of intra-articular infiltration of microfragmented aspirate of autologous adipose tissue compared to intra-articular infiltration of corticosteroids in the treatment of knee osteoarthritis	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2021-11-03	Instituto de Ortopedia e Traumatologia de Universidade de São Paulo	Geistlich Pharma do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9bsf32r	<NULL>	Knee Osteoarthritis.Absence of local or systemic infection.Absence of arthritis of rheumatologic origin.Clinical deformity (varus/valgus/flexo/recurvate)or radiographic &lt; 10 degrees.Patient able to understand the nature of the study.Informed consent filled in by the patient.Absence of any intra-articular procedure less than 3 months before the start of the study.Absence of clinical contraindications to the study.Absence of congenital or acquired disease generating large deformity in the knee that could interfere with the application of mesenchymal cells or interpretation of results.Absence of neoplasm under treatment.Non-pregnant patient.Absence of grade 3 obesity with BMI &gt;40 (kg/height in m2)	Loss to follow-up.Presence of serious/debilitating clinical condition.Presence of new orthopedic injuries relevant during the study period (severe joint trauma to the knee.fractures of the lower limb or new ligament injuries).death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-6vfg7r	Comparative effectiveness of two catheter locking solutions to reduce catheter-related bloodstream infection in hemodialysis patients.	Recruitment completed	Intervention	2016-08-11	<NULL>	<NULL>	953	Comparative effectiveness of catheter locking solutions with gentamicin/cefazolin versus taurolidine to reduce catheter-related  infection in hemodialysis patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Faculdade de Medicina de Botucatu- Unesp	Hospital Estadual de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-6vfg7r	<NULL>	Incident and prevalent patients on hemodialysis; folowed in the dialysis units of Botucatu Clinics Hospital and the Bauru State Hospital; using incident tunneled central venous catheter for hemodialysis	Patients Under 18; pregnant Women; with other types of dialysis access; with tunneled catheters implanted before November 2014; followed for less than six months after implantation of the catheter; with infection at the time of start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-7bvcpsg	Comparative effects of a mindfulness program developed for the brazilian context and an Internationally validated program on promoting mental health and socioemotional skills for children in public educational context	Recruitment completed	Intervention	2023-12-15	<NULL>	<NULL>	7712	Meditation and art therapy program for 9- and 10-year-old children as a promoter of mental health and socioemotional skills in the public educational context	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7bvcpsg	<NULL>	Ages between 9 and 10 years old; both sexes; informed consent from parents or guardians; enrolled and regularly attending a public elementary school	Students diagnosed with any psychological and/or psychiatric disorder; intellectual and cognitive disabilities; those using medication; those in the acute phase of such disorders; those already practicing meditation or related activities; or those who have done so in the past 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-2mxrcjw	Comparative effects of Viscosupplementation and Triamcinolone on quality of life in patients with Knee Osteoarthritis	Data analysis completed	Intervention	2025-11-17	<NULL>	<NULL>	8561	Viscosupplementation and Triancinolone: impact on the quality of life of patients with Knee Osteoarthritis	<NULL>	4, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Faculdade Ingá - UNINGÁ	<NULL>	<NULL>	<NULL>	Patients of both sexes aged 45 or older. Diagnosis of symptomatic osteoarthritis (OA) of the knee. Diagnosis confirmed by radiological examination. Must have sought outpatient care between January and March 2023	History of knee surgery or trauma. Use of oral chondroprotectors in the past year. Having received corticosteroid injections in the past year. Having undergone viscosupplementation in the past year	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:21
RBR-3m6cny	Comparative efficacy and safety study of dolutegravir and lopinavir/ritonavir in second-line treatment	Recruitment completed	Intervention	2016-02-22	<NULL>	<NULL>	926	"200304 - A phase 3b,randomised,open-label study of the antiviral activity and safety of dolutegravir compared to lopinavir/ritonavir both administered with dual nucleoside reverse transcriptase inhibitor therapy in HIV-1 (Type I virus of acquired immunodeficiency syndrome) infected adult
subjects with treatment failure on first line therapy"	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-07-29	ViiV Healthcare	GlaxoSmithKline	https://ensaiosclinicos.gov.br/rg/RBR-3m6cny	<NULL>	"HIV-1 infected subjects greater or equal to 18 years of age;

A female subject may be eligible to enter and participate in the study if she: is of non-childbearing potential defined as either post-menopausal (12 months of spontaneous amenorrhea and greater or equal to 45 years of age) or physically incapable of becoming pregnant with documented tubal ligation, hysterectomy, or bilateral oophorectomy or, is of child-bearing potential, with a negative pregnancy test at both screening and day 1 and agrees to use one of the protocol-defined methods of contraception to avoid pregnancy;

HIV-1 infection as documented by HIV-1 RNA greater or equal than 400 c/mL at screening; subject has been on a first-line treatment regimen consisting of an NNRTI plus two NRTIs for at least 6 months and is currently experiencing virologic failure to this first-line regimen defined as two consecutive (greater or equal to 7 days apart) HIV-1 RNA results of greater or equal to 400 c/mL; subjects must receive at least one fully active agent within the dual-NRTI background regimen for second line treatment; fully active is defined by the screening genotypic resistance report of the central laboratory (or a laboratory contracted by the central laboratory) showing no evidence of full or of partial resistance for a given NRTI which will be taken on study; subject is PI-naïve and Integrase inhibitor (INI)-naïve, defined as no prior or current exposure to any PI or INI; subject or the subject&apos;s legal representative is willing and able to understand and provide signed and dated written informed consent prior to screening"	Women who are breastfeeding;  any evidence of an active Centers for Disease Control and Prevention (CDC) Category C disease exceptions include cutaneous Kaposi&apos;s sarcoma not requiring systemic therapy and historic or current CD4+ cell levels less than 200 cells per cubic millimeter; subjects with severe hepatic impairment, class C, as determined by Child-Pugh classification; unstable liver disease, as defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, oesophageal or gastric varices, or persistent jaundice, cirrhosis, known biliary abnormalities, with the exception of Gilbert&apos;s syndrome or asymptomatic gallstones; anticipated need for hepatitis C virus, HCV, therapy during the randomised phase of the study; history or presence of allergy or intolerance to the study drugs or their components or drugs of their class; ongoing malignancy other than cutaneous Kaposi&apos;s sarcoma, basal cell carcinoma, or resected, non-invasive cutaneous squamous cell carcinoma, or cervical intraepithelial neoplasia; other localised malignancies require agreement between the investigator and the study medical monitor for inclusion of the subject; subjects who in the investigator&apos;s judgment, poses a significant suicidality risk. Recent history of suicidal behaviour and/or suicidal ideation may be considered as evidence of serious suicide risk; treatment with an HIV-1 immunotherapeutic vaccine within 90 days of screening; treatment with any of the following agents within 28 days of screening: radiation therapy, cytotoxic chemotherapeutic agents, systemically administered immunomodulators; treatment with any agent, other than licensed ART as allowed above with documented activity against HIV-1 in vitro/vivo within 28 days of first dose of investigational product. The exception is use of entecavir, in appropriate clinical situations, for treatment of hepatitis B, e.g. prior intolerance to Tenofovir, viral resistance to lamivudine (3TC)/Emtricitabine (FTC),  after discussion and agreement between the investigator and the medical monitor; exposure to an experimental drug or experimental vaccine within either 28 days, 5 half-lives of the test agent, or twice the duration of the biological effect of the test agent, whichever is longer, prior to the first dose of investigational product; any evidence of primary viral resistance to protease inhibitors or integrase inhbitors based on the presence of any major resistance-associated mutation; the subject&apos;s virus does not yield results using genotype at screening, assay data is essential for eligibility determination; any verified grade 4 laboratory abnormality, with the exception of grade 4 triglycerides. A single repeat test is allowed during the screening period to verify a result; any acute laboratory abnormality at screening, which, in the opinion of the investigator, would preclude the subject&apos;s participation in the study of an investigational compound; alanine aminotransferase, ALT, greater or equal than 5 times the upper limit of normal, ULN, or ALT greater or equal than 3xULN and bilirubin greater or equal than 1.5xULN (with more than 35% direct bilirubin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-64g476p	Comparative evaluation of At-home bleaching in patients with two different age groups - a parallel, single-blind, non-randomized controlled trial.	Not yet recruiting	Intervention	2022-04-06	<NULL>	<NULL>	6270	Clinical evaluation of the efficacy of at-home dental bleaching in patients of different age groups	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-64g476p	<NULL>	Patients aged between 15 and 24 years (young patients); patients between 45 and 59 years old (middle-aged adult patients); elderly patients (60-80 years); presenting a good state of general and oral health; absence of caries; absence of restorations bigger than 1/3 of tooth structure and endodontic treatment in anterosuperior teeth; with upper right canine (element 13) the participants must present color A2 or lesser value according to the value-oriented color scale (Vita Classical, Vita Zahnfabrik, Bad Sa¨ckingen, Germany).	Participants using an orthodontic appliance; severe internal discoloration of the tooth (tetracycline stains, fluorosis and non-vital teeth); bruxism; pregnant / lactating women; use of medications (analgesics or anti-inflammatory drugs); participants who had already undergone previous tooth whitening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-4ncxc27	Comparative evaluation of different digital impression techniques for full-arch implant-supported fixed dental prostheses	Recruiting	Intervention	2026-01-02	<NULL>	<NULL>	8687	Comparative evaluation of photogrammetry, intraoral scanning and accuracy of conventional limpression for implant-supported fixed dental prostheses of the complete arch	<NULL>	n/a, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-30	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Patients who are completely edentulous in the upper or lower arch; systemically healthy patients; patients with good cognition; aged between 18 and 60 years	Unavailability of bone tissue to allow implant placement; smokers; pregnant or breastfeeding women; patients with general contraindications for undergoing surgical procedures; chronic users of medications that affect bone metabolism	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-7ms43m	Comparative evaluation of the mandible head / mandibular fossa relationship in patients with symptomatology or not in two positions by computed tomography	Data analysis completed	Intervention	2019-10-24	<NULL>	<NULL>	3129	Comparative evaluation of the mandible head / mandibular fossa relationship in asymptomatic and symptomatic adult individuals in the centric and maximal intercuspal clearance through cone beam computed tomography	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7ms43m	<NULL>	To participate in the study, besides belonging to the pre-established age groups for each group of this study, the individuals of the sample should present all dental elements (the presence of third molars being optional) and the absence of previous report of unilateral or bilateral articular ankylosis. or significant trauma in the TMJ region.	The criteria used to exclude any individuals from participation in this research were: previous orthodontic treatment, signs of advanced periodontal disease, subjects undergoing previous occlusal adjustment, history of facial trauma, systemic diseases with anatomical degeneration of the mandible or mandibular fossa, trismus. and teeth with active caries process that can cause odontogenic pain. These criteria were determined with the objective of eliminating factors that could mask the initial conditions, introduce etiological and / or iatrogenic factors or prevent the implementation of the methodology present in this work. RDC / TMD exclusion factors such as myospasm, myositis, muscle contracture, polyarthritis, acute traumatic injuries, and temporomandibular joint infections were also used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-9z82kj	Comparative evaluation of the Protection from the Protective Films through instrumental measures and images	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4307	Comparative evaluation of the Protection Potential of Protective Films through instrumental measures and images analysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-07	3M do Brasil Ltda	3M do Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-9z82kj	<NULL>	Healthy study subjects; intact skin on test site; agreement to adhere to the procedures and requirements of the study and to report to the institute on the day (s) and at the time (s) scheduled for the assessments; ability to give consent for participation in the study; aged from 18 to 75 years old; male / female / both genders; phototype (Fitzpatrick): I to III; signature of the informed consent form by the subject; subjects who respect the conditioning period not applying topical medications, creams or other skin cleansing products in the assessment sites 3 days before visit 02 (D1)	pregnancy or breastfeeding; skin pathology on the area of product application; type 1 diabetes mellitus: insulin-dependent diabetes, presence of complications resulting from diabetes (retinopathy, nephropathy, neuropathy), presence of dermatosis related to diabetes (lipoidic necrobiosis, plantar ulcer, ring granuloma, opportunistic infections); antecedents of episodes of hypoglycemia, diabetic ketoacidosis and/or hyperosmolar coma; immunological insufficiency; use of systemic corticosteroids or immunosuppressant drugs; skin diseases: vitiligo, psoriasis, lupus, atopic dermatitis; any other condition that, in the investigator opinion, might directly interfere with the study or put the subject health under risk; smokers; subjects in menopause or who state being suffering from heat waves; excessive hairiness in the experimental site; current use of the following topical or systemic medications: corticosteroids, immunosuppressant and anti-histaminic drugs; history of reaction to the category of the tested product, creams, skin cleansers, cosmetics, personal care products and/or topical medicines; Participating in another study, having participated in another study in the two weeks prior to the start of the study or intending to participate in another study during the study period; history of sun hypersensitivity (skin defect or damage to sensitive or light-reactive skin);  tattoos, scars, spots or other blesmihes on the assessment areas that might interfere with the study assessments; skin marks on the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, sunburn, vascular malformations, scars, increased hairiness, freckles, warts, tattoos and scars); subjects who have applied any topical medications, creams, or other skin cleansers in the assessment sites during the washout period;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-2kvnqrm	Comparative evaluation of three different Gingival Grafts	Recruitment completed	Intervention	2023-10-03	<NULL>	<NULL>	6772	Comparative clinical study between conventional Free Gingival Grafts (EGL) and Inverted Free Gingival Connective Tissue Grafts (EGLCI), in split mouth: study in humans	<NULL>	array, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2017-07-19	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2kvnqrm	<NULL>	Healthy patients; both genders; non-smokers; 18 and 60 years old; absence of periodontal disease in the teeth of interest of the research; with indication of increase of the band of keratinized mucosa bilaterally in the region of at least 3 mandibular premolars.	Patients with systemic problems that contraindicate oral surgeries; pregnant women; who were taking or had taken controlled medications and antibiotics in the last 6 months preceding the survey, presence of periodontal disease in the areas of interest of the survey; cognitive impairment; users of illicit drugs or alcohol and smokers; former users of illicit drugs, former smokers and former alcoholics could only be included in the study if they had fully quit their addiction at least 6 months before the start of the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-3ncv48k	Comparative Evaluation of two dermocosmetic products with a Skin Tone Standardization Function	Recruitment completed	Intervention	2023-02-23	<NULL>	<NULL>	5919	Comparative effectiveness evaluation of two seruns through clinical effectiveness assessments, instrumental measurements, image analysis and self-assessment by research participants under normal use conditions (E000311A-01/03)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-12	Allergisa Research Institute	BDF Nivea Ltda	https://ensaiosclinicos.gov.br/rg/RBR-3ncv48k	<NULL>	Healthy study subjects; intact skin on test site; agreement to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; ability of giving consent for participation in the study; aged from 18 to 65 years old; female study subjects; subjects presenting phototype (Fitzpatrick) I to II, III, IV and V to VI; with homogeneous distribution between them 50% of subjects presenting melasma of any intensity on both half faces; according to the Institute scale; solar lentigo confirmed by a dermatologist	Intense sun exposure or tanning session within one month before the initial assessment or intention of being intensely exposed to sunlight or tanning sessions during the study period;  presenting intense tanning signs, according to assessment of study physician; aesthetic and/or dermatological treatment performed on the face within 02 months before initial visit; beginning or change of hormone replacement treatment or medication contraception method within the last 03 months; pregnancy or breastfeeding; skin pathology on the product application site; type 1 Diabetes Mellitus: insulin-dependent diabetes, presence of complications resulting from diabetes (retinopathy, nephropathy, neuropathy); presence of dermatosis related to diabetes (lipoidic necrobiosis, plantar ulcer, ring granuloma, opportunistic infections); antecedents of episodes of hypoglycemia, diabetic ketoacidosis and/or hyperosmolar coma; immunological Insufficiency; current use of the following topical or systemic medications: corticosteroids, immunosuppressive and anti-histaminic drugs; skin diseases as vitiligo, psoriasis, atopic dermatitis; history of reaction to the category of the product tested; other diseases or medications that might directly interfere with the study or put the subject&apos;s health under risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-4wt3h7	Comparative evaluation of two motivational methods performed during Periodontal Treatment in patients with Gingival Disease	Data analysis completed	Intervention	2020-05-28	<NULL>	<NULL>	3888	"Comparative evaluation of two motivation programs carried out during Therapy
Basic Periodontal disease in patients with Gingival and Periodontal Disease"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Centro de Estudos Superiores de Maceió	Centro de Estudos Superiores de Maceió	https://ensaiosclinicos.gov.br/rg/RBR-4wt3h7	<NULL>	"Systemically healthy patients; patients over 18 years of age and under 65
years; patients able to read and sign the IC; patients diagnosed with periodontal disease and in need of basic periodontal therapy; patients who have access to an instant messaging application (WhatsApp)."	"Patients with any pathology
that negatively influences tissue healing (eg diabetes melitus); patients using any drugs that negatively influence the oral environment; pregnant and nursing patients; patients with chronic renal failure; patients with advanced liver disease (eg, cirrhosis); patients with decompensated hypertension or an increased risk of cardiovascular disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-7nww56	Comparative of differents protocols of low level laser therapy as prevent of oral mucositis in patients undergoing bone marrow transplant	Terminated	Intervention	2019-12-17	<NULL>	<NULL>	4757	Comparative of differents protocols photobiomodulation as prevent of oral mucositis in patients undergoing hematopoietic stem cell transplantation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-12	A.C. Camargo Cancer Center	A.C. Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-7nww56	<NULL>	Voluntary patients undergoing hematopoietic stem cell transplantation; of both sexes; from than 18 years.	Previously transplanted hematopoietic stem cell patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-66tppc	Comparative results of the use of corticoid and hyaluronic acid in the treatment of shoulder arthrosis.	Recruitment completed	Intervention	2019-02-28	<NULL>	<NULL>	2494	Hilano G-F 20 versus triamcinolone in the treatment of primary shoulder osteoarthrosis. Randomized controlled clinical trial.	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66tppc	<NULL>	Adult patients without distinction of age or gender; Present diagnosis of primary shoulder osteoarthrosis with radiological confirmation, Segment availability during the study period; Have had previous conservative treatment without improvement of symptoms for a minimum period of 6 months; EVA of pain&gt; or equal to 4; Have signed an informed consent form to participate in the study.	Shoulder previous surgery, Shoulder viscosupplementation, Rotator cuff arthropathy, Adhesive capsulitis, Shoulder osteoarthrosis secondary to fracture, infection, osteonecrosis, rheumatologic disease, Continuous use of corticoid, Chronic treatment with immunosuppressive or anticoagulant drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-6wgwxsy	Comparative search between  HIV medicines  in Covid-19	Not yet recruiting	Intervention	2022-03-14	<NULL>	<NULL>	5275	Randomized double-blind clinical trial comparing Atazanavir + Ritonavir + Doxycycline versus Atazanavir + Ritonavir in patients with laboratory or clinical diagnosis for Covid-19, in the state of Pernambuco and Alagoas – Brazil	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital das Clínicas da Universidade Federal de Pernambuco	Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL	https://ensaiosclinicos.gov.br/rg/RBR-6wgwxsy	<NULL>	outpacients with positive diagnosis for COVID-19	Patients with indication for hospital admission;  patients with other protease inhibitors;  pregnant;  infants;  more than 5 days  from the onset of symptoms, HIV positive patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9yfmhcx	Comparative study before and after speech therapy in patients with  Apnea	Data analysis completed	Intervention	2025-09-22	<NULL>	<NULL>	8295	Comparative pre- and post-study of an orofacial myofunctional therapy program in patients with Obstructive Sleep Apnea	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-26	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9yfmhcx	<NULL>	Adult patients; men and women; aged between 19 and 65 years; literate; diagnosed with obstructive sleep apnea confirmed by polysomnography regardless of the degree of apnea; with a body mass index less than 35 kg/m²; who participated in the 12 session therapeutic program lasting an average of 3 months; who underwent polysomnography again at the end of the program and signed the informed consent form	Male and female patients with other sleep disorders; previous apnea treatment; use of continuous positive airway pressure; intraoral appliances and surgery; use of alcohol; stimulants or sedatives; major craniofacial alterations; failure to comply with the therapeutic program; no polysomnography examination before or after the therapeutic program; or not accept the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-2335ks	Comparative study between a phytotherapeutic and chlorhexidine on alveolar healing	Data analysis completed	Intervention	2017-10-31	<NULL>	<NULL>	1455	Comparative Study of the Elixir Sanativo and Chlorhexidine on Alveolar Healing	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-07	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2335ks	<NULL>	systematically healthy patients; indication for contralateral tooth extraction from extensive carious lesion, periodontal disease or orthodontic indication, without osteotomy or odontosection	uncontrolled systemic pathologies; smokers; alcoholics; pregnant women; patients allergic to one or more drugs used; patients who have used anti-inflammatory drugs or antibiotics in the last 7 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-2hgwvgy	Comparative study between CO2 laser and Fractional Radiofrequency in the treatment of Vaginal Atrophy	Recruitment completed	Intervention	2023-02-07	<NULL>	<NULL>	5881	Microablative CO2 laser versus Fractionated Microablative Radiofrequency in the treatment of Genitourinary Menopause Syndrome: a controlled, randomized, double-blind, non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Brasil	Cássia Caroline Garcia Dalbem Teles	https://ensaiosclinicos.gov.br/rg/RBR-2hgwvgy	<NULL>	Physiologically postmenopausal women with amenorrhea longer than one year and plasma follicle-stimulating hormone dosage greater than 40 U/l and estradiol less than 25 pg/mL. Age between 50 and 70 years. Present clinical symptoms of the menopausal genitourinary syndrome. Current cervical cytological exam performed in the last six months negative for neoplasia	Women who have received any form of hormone replacement therapy in the past six months. Women who have used non-hormonal vaginal lubricants or moisturizers in the past month. Presence of active genital infections. Patients with a history of genital herpes who are unwilling to take oral Acyclovir prophylaxis. Women who have chronic inflammatory diseases that make the procedures unfeasible. Carriers of thrombophilia or regular users of anticoagulants or platelet antiaggregants. Patients that present vaginal prolapse of second or third degree according to the Pelvic Organ Prolapse Quantification System. Patients with a history of photosensitivity. Those who have had previous treatment with endovaginal CO2 laser or micro ablative Radiofrequency in any period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-65rzrv	Comparative study between Diode Laser Surgery and Filtering Surgery as a Primary Surgical Procedure for patients with Glaucoma	Recruiting	Intervention	2020-06-24	<NULL>	<NULL>	3950	A Prospective randomized multicenter study comparing Transscleral Cyclophotocoagulation and Trabeculectomy as a Primary Surgical Procedure in Glaucoma	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-07	Centro de Referência em Oftalmologia da Universidade Federal de Goiás (CEROF-UFG)	Centro de Referência em Oftalmologia da Universidade Federal de Goiás (CEROF-UFG)	https://ensaiosclinicos.gov.br/rg/RBR-65rzrv	<NULL>	"The study will include patients aged over 18 years with the following glaucoma subtypes: POAG, pigmentary glaucoma (PG), pseudo-exfoliation glaucoma (PEX), and cortisone glaucoma. The patients must have glaucoma refractory to clinical treatment and not in the target IOP, defined by the physician responsible for the case or with VF progression (22) confirmed with the current IOP.
All patients must have at least one reliable SITA Standard 24-2 VF exam (Humphrey Systems, Dublin, CA, USA) and with characteristic glaucoma changes according to the criteria proposed by Hodapp-Parrish-Anderson (HPA) (23), OD examination showing typical glaucoma lesion, i.e., neural rim focal thinning or global loss, vascular changes, and/or localized RNFL defects (24), and the ability to perform VF testing in at least one eye.
Pseudo-phakic patients must have a history of a previous cataract surgery using the phacoemulsification technique (PHACO ) with a corneal incision without stitches and intraocular lens (IOL) implantation within a capsular bag and without complications described in the patient’s medical chart and/or confirmed with detailed examination of the eye in mydriasis."	"Exclusion criteria will be as follows: absence of light perception vision; loss or deficit of vision in any eye of unknown cause or other than glaucoma; unreliable VF; aphakia or any other changes at biomicroscopy or ophthalmoscopy that may affect VF examination, such as age-related macular degeneration (AMD) or retinal detachment (RD); or recent participation in another research protocol (six months). VF will only be an inclusion criterion for patients with corrected VA better than 20/200. Patients below this level will not undergo the VF exam to be included in the study.
Pregnant or lactating patients will be excluded from the study. Patients with a history of any other intraocular surgery (except cataracts, as previously described); previous anti-glaucoma surgery (any technique); need for other surgeries concomitant with glaucoma surgery, such as for cataracts; aphakia; history of cataracts with complications, such as posterior capsule rupture, vitreous loss, or IOL implantation in the groove; conjunctival scars that may prevent or hinder TREC, such as sequelae from burns or pterygium surgery; corneal scars that may hinder the IOP measurement; or history or evidence of uveitis (active or not) will also be excluded.
Patients with ocular hypertension, normal pressure glaucoma (NPG), PCAG, neovascular glaucoma (even treated), congenital or juvenile glaucoma, endothelial iridocorneal syndrome, traumatic glaucoma, secondary glaucoma, or any conditions that, at medical discretion, will contraindicate any of the techniques proposed in the study will also be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-5symrd	Comparative study between endoscopic and conventional surgery for lumbar disc herniation	Recruitment completed	Intervention	2018-10-02	<NULL>	<NULL>	2257	Randomized trial comparing endoscopic microdiscectomy and conventional open microdiscectomy for the treatment of radiculopathy due to lumbar disc herniations	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Instituto de Ortopedia e Traumatologia do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5symrd	<NULL>	Radiating pain to lower limbs. Lumbar disc herniation with nerve compression observed in MRI. Clinical symptoms concordant with MRI images. Six weeks of conservative treatment without significant improvement. Both men and women are included.	Motor weakness grade III or less attributed to nerve compression. High migrated disc herniation. Previous lumbar surgery on the same level. Doble compression on the nerve root. Loss of disc high grater than 50%. Any other surgery contraindication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-109k3fmj	Comparative study between Intrastromal Injection of autologous blood and C3F8 Injection for treatment of Corneal Hydrops	Recruiting	Intervention	2023-09-20	<NULL>	<NULL>	6454	Comparison between Intrastromal Injection of autologous blood and C3F8 Injection for the treatment of Severe Acute Corneal Hydrops	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-30	Universidade Federal de São Paulo	Departamento de Oftalmologia – Unifesp	https://ensaiosclinicos.gov.br/rg/RBR-109k3fmj	<NULL>	Patients older than ten years of age; both genders; patients who were clinically diagnosed with Acute Corneal Hydrops; patients who signed the medical consent term; availability for all the study visits	Having been submitted to ocular surgery in the last six months; presenting Hydrops condition for more than two months; occurrence or suspicion of occurrence of infectious episodes on the ocular surface; presence of Corneal Perforation or Atalamia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-4ckch8	Comparative study between Laser therapy versus Pelvic Muscle Training in women with Stress Urinary Incontinence	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	6860	CO2 Laser Therapy versus Urogynecology  Physiotherapy  in SUI :  prospective randomized non inferiority study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-08	Faculdade de Ciência Médicas da Universidade Estadual de Campinas	Clínica Condé	https://ensaiosclinicos.gov.br/rg/RBR-4ckch8	<NULL>	Women with 18 years old or over; with sintoms of Stress Urinary Incontinence - SUI; with positive effort test or valsalva manouver and/or urodynamics findings of Stress Urinary Incontinence - SUI and residual volume less than 100 ml or 20 % of voided volume superior 300ml; in case of women with a negative stress test with anamnesis suggesting Stress Urinary Incontinence , women with a positive urodynamic study for Stress Urinary Incontinence will be included	Women with overactive bladder; or urodynamic finding of detrusor overactivity; women with repetitive  Urinary Tract Infection; woman with previous urogynecology surgeries; with previous treatment of radioterapy or Pelvic Organ Prolapse (POP) more than 2 years; women  with previous and recently history of bladder stone; urinary fistula  or divertíiculum	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-109kzq9y	Comparative study between Local Anesthesia and Dorsal Muscle Anesthesia in Video Thoracic Surgery	Recruiting	Intervention	2021-03-23	<NULL>	<NULL>	4579	Randomized clinical trial simple blind comparative between Local Preemptive Anesthesia and Spinal Erector Muscle in Video Thoracoscopic  Thoracic Surgery	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2020-11-30	IGHOR RAMON PALLU DORO PEREIRA	HOSPITAL NOSSA SENHORA DAS GRAÇAS	https://ensaiosclinicos.gov.br/rg/RBR-109kzq9y	<NULL>	Adult patients over 18 years of age, with a surgical indication for the treatment of any chest diseases, which can be performed by uni or multiport minimally invasive techniques (VATS). Patients with classification by the American Society of Anesthesiologist (ASA 1, 2 and 3)	Patients under 18 years of age; Patients with absolute contraindication to the surgical procedure using a minimally invasive technique (VATS); Patients who need a surgical approach that does not allow the performance of the control or intervention procedure of this research; Patients with absolute contraindication to the anesthetic drugs used in the procedure; Patients with absolute contraindication to postoperative analgesic drugs in the hospital&apos;s basic protocol (dipyrone and Bextra); Patients with a medical diagnosis of dementia, mental retardation, delirium or other conditions that affect the patient&apos;s verbal and lucid response; Pregnant patients; Patients with a current or past history of abuse of licit or illicit drugs; Emergency operation; Illiterate patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-78zfpxd	Comparative study between Local Freezing and back injection for Pain control after thoracic surgery	Not yet recruiting	Intervention	2025-01-03	<NULL>	<NULL>	7634	Cryoanalgesia versus thoracic epidural analgesia for Pain control in the postoperative period of thoracic surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78zfpxd	<NULL>	Patients of either gender; 18 years of age or older; undergoing invasive thoracic procedures, whether thoracotomy, sternotomy, or videothoracoscopy	Patients undergoing sympathectomy; patients undergoing procedures that do not access the pleural cavity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-8cykwc3	Comparative study between lung expansion maneuvers in patients undergoing mechanical ventilation	Recruitment completed	Intervention	2023-12-04	<NULL>	<NULL>	6629	Comparative study between alveolar recruitment maneuvers, chest compression and decompression maneuvers and breath stacking maneuvers in patients undergoing mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Hospital e Maternidade Galileo	Hospital e Maternidade Galileo	https://ensaiosclinicos.gov.br/rg/RBR-8cykwc3	<NULL>	Patients with up to 72 hours of admission to the Intensive Care Unit (ICU) using mechanical ventilation (MV); patients of both sexes; aged 18 to 80 years; patients with hemodynamic stability, mean arterial pressure (MAP≥60 mmHg), pulmonary gas exchange with partial pressure of oxygen greater than or equal to 60 mmHg (PaO2 ≥ 60 mmHg), inspiratory fraction of oxygen greater than or equal to 60% (FiO2≥60 %), positive expiratory pressure less than or equal to 10 cmH2O (PEEP≤10 cmH2O), adequate oxygen saturation (SpO2≥95%), acid-base balance; sedated or weaned patients; informed consent form signed by the responsible family member	Bronchopleural fistula; pulmonary thromboembolism; patients undergoing postoperative cardiac surgery; thrombocytopenia (&lt;50,000/mm³); severe traumatic brain injury with intracranial hypertension (PIC≥20mmHg); flail chest and undrained pneumothorax	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-9tqcr5q	Comparative study between Standard Dressing and Standard Dressing with Plant Extract of Jamelão in the treatment of Wounds on lower limbs	Recruitment completed	Intervention	2020-12-28	<NULL>	<NULL>	4449	Prospective, randomized, double-blind, comparative study on Healing of lower limb Stasis Ulcers between Standard Dressings and Standard Dressings with Syzygyum cumini Extract	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-09-01	Gilson Roberto de Araujo	FUNDACAO DE APOIO A PESQUISA DO DISTRITO FEDERAL FAPDF	https://ensaiosclinicos.gov.br/rg/RBR-9tqcr5q	<NULL>	Patients older than 18 years; of both sexes; who have signed the informed consent form; patients with venous ulcer in the lower limb for more than two weeks; ulcer with an area greater than three cm²	Ulcer patient being treated with antibiotic (oral or injectable), or who has used antibiotic (oral or injectable) for less than two weeks; ulcers that affect muscle or tendons; pregnant women; breastfeeding women; women of childbearing potential who do not use contraception; enlarged leukocytes; ulcer culture fragment with evidence of infection; patients with systemic infection; ankle/arm pressure index (ABI) &lt;0.85; patients with diseases that hinder healing: including liver, kidney, immune, rheumatic, hematological, neurological diseases, cancer (except non-melanoma skin cancer); difficulty in doing outpatient monitoring; known allergic reaction to any of the components used in dressings; ulcer that could not be characterized as of venous origin; chronic use of corticosteroids (for more than 15 days); use of chemotherapy; edema of lower limbs from another source, other than venous; participation in any other clinical study in the past year	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-4d9d42n	Comparative study between the effect of pharmacological and non-pharmacological measures on preoperative anxiety in preschoolers undergoing  outpatient surgeries	Recruitment completed	Intervention	2023-02-08	<NULL>	<NULL>	5886	Comparative study between the effect of pharmacological and non-pharmacological measures on preoperative anxiety in pediatric patients undergoing elective outpatient surgeries: prospective, randomized, blinded study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-20	Casa de saúde assistência médica infantil de urgência	Casa de saúde assistência médica infantil de urgência	https://ensaiosclinicos.gov.br/rg/RBR-4d9d42n	<NULL>	Patients who will undergo circumcision; aged between 2 and 7 years; with physical status according to the American Society of Anesthesiologists (ASA) I and II	"Patients with Autism Spectrum Disorder (ASD); Attention Deficit Hyperactivity Disorder (ADHD); Patients with a previous history of paradoxical effect of Midazolam or hypersensitivity to any of its components; patient with serious diseases in organs such as kidney, liver, lung, heart, brain and bone marrow; patients who use psychostimulant drugs or antidepressants
   Serious diseases in organs such as kidney, liver, lung, heart, brain and bone marrow.
  Use of psychostimulant or antidepressant drugs"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-3dv5t8	Comparative study between the effectiveness of Transcutaneous Electric Nerve Stimulation (TENS) and Low Power Laser devices in the scar incision in post-cesarean pain	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3721	Comparative study between Transcutaneous Electric Nerve Stimulation (TENS) and Low Power Laser in post-cesarean section pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-3dv5t8	<NULL>	Postpartum women residing in Patos de Minas - MG, who are in the immediate puerperium (3 to 10 days postpartum), with pain at the incision site, with spinal anesthesia before the surgical procedure, absence of pathology will be included in the study genitourinary.	Patients with changes in sensitivity, demyelinating diseases, spinal cord trauma, hemorrhage, infection, fever, anesthetic complications, arterial hypertension will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-8fxzwfh	Comparative study between the use or not of sutures in upper third molar surgeries	Recruiting	Intervention	2024-09-16	<NULL>	<NULL>	7346	Comparative evaluation of the use or not of sutures in upper third molars surgery - a splith mouth randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJM	Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJM	https://ensaiosclinicos.gov.br/rg/RBR-8fxzwfh	<NULL>	Patients over 18 years of age; both genders; no impairment of general health according to medical history and physical examination; patients with indication for extraction of bilateral maxillary third molars, erupted or partially erupted, asymptomatic	Patients classified as ASA III or ASA IV, according to the American Association of Anesthesiology; use of anti-inflammatories within 15 days prior to surgery; smoking patients; pregnant and breastfeeding women; patients with a history of pericoronitis; patients with cognitive disorders that make it impossible to understand and execute commands; withdrawal of consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-9t36r35	Comparative study between the video laryngoscope manufactured by printer and the traditional model in Tracheal Intubation	Not yet recruiting	Intervention	2023-03-24	<NULL>	<NULL>	5959	Comparative study between the 3D-printed videolaryngoscope by lipecin (ufcspa) and the macintosh model in the management of the airways of patients undergoing Tracheal Intubation: clinical, randomized and blinded trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Irmandade da Santa Casa de Misericordia de Porto Alegre	Irmandade da Santa Casa de Misericordia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9t36r35	<NULL>	Patients of both genders; over 18 years old and under 70 years old; candidates for surgeries under general anesthesia and in need of tracheal intubation; with risk classification by the American Society of Anesthesiology	Urgent/emergency surgeries; upper airway surgeries; head and neck surgeries; orthognathic surgeries; surgeries with planned nasotracheal intubation; previous surgeries on the cervical spine; patients with a body mass index greater than 35; patients with cervical disc injury; with spine fractures; patients using a cervical collar; patients with head and neck injuries that preclude the use of standard intubation techniques; patients with type I diabetes; syndromic patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-6x6qy2	Comparative study between three types of mouthguards used to prevent lesions in the mouth and influence on mouth functions.	Data analysis completed	Intervention	2020-10-08	<NULL>	<NULL>	4331	"Comparative study of 3 types of mouthguards used in trauma prevention
maxillomandibular and its effects on the function of the oral cavity"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6x6qy2	<NULL>	American football players, from the Bulls Potiguares club, male and registered in the North American League of American football.	Those who used full dentures, removable partial dentures, orthodontic appliances, as well as those who complained of recurrent ulcerations were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-9396ksd	Comparative study between Topical Coverages on critically colonized or infected wounds in patients with Pressure Injury	Recruiting	Intervention	2024-10-08	<NULL>	<NULL>	7410	Comparative study between Topical Coatings of Dialkyl Carbamoyl Chloride vs Polyamide with Silver	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-03-29	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9396ksd	<NULL>	Both sexes; patients aged between 18 and 80 years; pressure injuries requiring surgery (Grades 3 or 4); presence of critical colonization (positive tissue culture) or infection of wound (clinical and laboratory signs of infection); care by the Plastic Surgery Complex Wounds Group	Pressure injuries without surgical indication (Grades 1 or 2); presence of uncontrolled systemic disease; failure to collect intraoperative cultures; patients with BMI&gt;35; patients with diseases that compromise immunity; allergy to silver or dialkyl carbamoyl chloride acetate; non-agreement to participate in the study and/or sign the informed consent form; change of conduct; loss of follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3ksnxkm	Comparative Study between Transcranial Direct Current Stimulation and Binaural Vibro-Acoustic Brain Stimulation in Parkinson&apos;s	Recruiting	Intervention	2023-06-28	<NULL>	<NULL>	6184	Comparative study between transcranial direct current stimulation and binaural vibro-acoustic brain stimulation in Parkinson&apos;s patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-3ksnxkm	<NULL>	Have a diagnosis of Parkinson&apos;s Disease; in stage 2 or 3 of the disease; both genders; being between 55 and 70 years old; with independent gait	Make use of Deep Brain Stimulation; make use of cochlear implants; having uncontrolled labyrinthitis; having uncontrolled hypertension	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-9m943sp	Comparative study between two modalities of Diode Laser Surgery in patients with Refractory Glaucoma	Recruiting	Intervention	2023-09-12	<NULL>	<NULL>	6427	A randomized clinical trial of slow coagulation (SC-CPC) vs subliminal subthreshold (SS-CPC) transscleral diode laser cyclophotocoagulation procedure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9m943sp	<NULL>	Patients between 18 and 80 years of age; Both genders; Uncontrolled intraocular pressure despite maximal topical therapy; Impossibility of performing trabeculectomy; Absence of previous cyclodestructive procedure	Single eyed patients; Albino phenotype; Previous ocular history of uveitis, surgery or corneal disease that precludes an intraocular pressure measurement; Presence of significant scleral thinning; Any medical conditions that prevent these individuals from providing reliable and valid data for the study; Patients enrolled in other prospective clinical trials	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-4w2qwh	Comparative study between two techniques of applying Dry Needling to painful neck points in young adults	Recruiting	Intervention	2019-09-20	<NULL>	<NULL>	2981	Comparative study between two techniques of  Dry Needling applying on trigger points in young adults with Neck Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-21	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-4w2qwh	<NULL>	Of both sexes; aged between 18 and 30 years; with pain in the cervical region (neck pain); presence of upper trapezius trigger points and scapular lift	Individuals who are using pain-reducing medication (s) and / or have effects on skeletal muscle, anticoagulant medications, individuals with decompensated diseases, haemophilia, who are allergic to needle metal, with needle phobia or who are undergoing some other treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-58j572j	Comparative Study for the Feasibility of a Device for Non-Invasive Clinical Analysis	Recruiting	Intervention	2024-02-20	<NULL>	<NULL>	8248	Comparative Clinical Trial for the Viability of the Progenos® Medical Device	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Nanotimize Tecnologia Ltda.	Nanotimize Tecnologia Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-58j572j	<NULL>	Men or women with no age limit; be able to sign the ICF approved by the CEP and execute and understand all study procedures and instructions.	Subjects who do not agree to participate in the clinical trial and do not sign the ICF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-33vyhm	Comparative study of analgesia by the use of intravenous and subarachnoid clonidine in patients submitted to Videoolaparoscopic Cholecystectomy	Recruitment completed	Intervention	2018-06-29	<NULL>	<NULL>	1942	Comparative study of the use of intravenous and subarachnoid clonidine in patients submitted to Videoolaparoscopic Cholecystectomy	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2017-08-23	Fundação Universidade do Amazonas	Hospital Universitário Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-33vyhm	<NULL>	Voluntary patients; of both sexes; with full autonomy; ages ranging from 18 to 50 years; weight between 50 and 100 kg; with diagnosis of cholelithiasis; classification I or II of the physical state according to the scale of the American Society of Anesthesiologists.	Patients who refuse to sign the informed consent form (EHIC); withdrawals; pregnant or nursing mothers; indigenous peoples; minor or legally incapable; patients with special needs; patients on uninterrupted use of analgesics; with a history of hypersensitivity to any of the medications used in the procedure; patients diagnosed with depression; patients with liver disease, nephropathy or with blood coagulation disorders; conversion of videolaparoscopic surgery in conventional open surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8ntwmyq	Comparative study of analgesic efficacy between phosphate codeine in combination with paracetamol and oxycodone hydrochloride, after extractions of impacted lower third molars.	Recruitment completed	Intervention	2021-07-07	<NULL>	<NULL>	4777	Comparative study of analgesic efficacy, safety and acceptability between phosphate codeine in combination with paracetamol and oxycodone hydrochloride, after extractions of impacted lower third molars.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8ntwmyq	<NULL>	Patientes of both sexes; aged over 18; with similar dental impaction; absence of systemic diseases or locoregional changes; without contraindication to the use of dexamethasone, paracetamol, codeine phosphate or oxycodone; absence of a history of hypersensitivity to mepivacaine.	Patients with records containing insufficient or inadequately filled data; patients who did not return for the second extraction would be excluded from the final sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-92kyfck	Comparative study of Anterior Cruciate Ligament Reconstruction with Peroneus Longus tendon x Hamstring tendon grafts	Not yet recruiting	Intervention	2023-05-26	<NULL>	<NULL>	6111	Randomized clinical trial comparing the functional outcome of patients undergoing Primary Reconstruction of the Anterior Cruciate Ligament with ipsilateral Peroneus Longus tendon x Hamstring tendon grafts after a 2-year follow-up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92kyfck	<NULL>	Patients with anterior cruciate ligament injury with surgical indication, with or without menisci injuries; Both genders	Presence of associated ligament injuries needing reconstruction; Patients with indication of associated procedures, such as osteotomies around the knee; Presence of associated fractures or other pathological conditions of the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-96g5cq	"Comparative study of Dexamethasone associated with
Nimesulide and Dexamethasone plus Paracetamol in
control of Pain, Swelling and postoperative Oral Opening Difficulty"	Data analysis completed	Intervention	2020-01-20	<NULL>	<NULL>	3385	"Comparative study between Dexamethasone co-administered with
Nimesulide and Dexamethasone co-administered with Paracetamol in
postoperative Pain control, Edema and Trismus"	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2017-06-20	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-96g5cq	<NULL>	"Voluntary patients, coming from spontaneous demand from the Unified Health System (SUS), attended at the dependencies of the UERN Dentistry Course;
Between 16 and 45 years old;
Agree to participate in research after reading the Informed Consent Form (ICF);
Classified according to the American Society of Anesthesiology (ASA), in group I (normal healthy, with no systemic changes or continuous use of medications);
With indication of lower third molar extraction, bilaterally. These, necessarily, with the same degree of inclusion as compared to their contralateral, following the classifications of Pell and Gregory and Winter."	"Report having had unpleasant previous experiences (reactions or allergic processes) to any of the drugs used in this research;
Use concomitant medication (except for oral contraceptives);
Do not fit into the planning of surgical and anesthetic techniques;
Not returning for the second surgery, (surgery on the opposite side);
Do not return to the assessments;
Inability to answer the questionnaires;
Do not correctly fill in the evaluation forms."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-3q6jfwp	Comparative study of different therapeutic modalities for controlling postoperative pain in proximal femur surgery	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7661	Comparative study between pericapsular nerve block (PENG BLOCK) associated with the lateral femoral cutaneous nerve, iliac fascia block and intrathecal morphine in postoperative pain after proximal femur surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Secretaria Estadual de Saúde - RJ	Secretaria Estadual de Saúde - RJ	https://ensaiosclinicos.gov.br/rg/RBR-3q6jfwp	<NULL>	Participants over 18 years of age; of both sexes; undergoing surgery to correct a fracture of the proximal end of the femur	Allergy or intolerance to any of the drugs used in the study; liver failure; estimated glomerular filtration rate &lt; 15 mL/min/1.73 m2; known or suspected coagulopathy; pre-existing neurological or anatomical deficits in the lower extremities; cognitive impairment with difficulties in assessing pain and severe psychiatric illness; chemical dependency; history of mental illness; hemoglobin less than 9 mg/dl; conversion of spinal anesthesia to general anesthesia; blood transfusion; duration of surgery longer than 3 hours; change of surgical plan or orthopedic complication during surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-52r82gy	Comparative study of donated corneas with and without Descemet&apos;s membrane in corneal transplants with perforation during surgery	Not yet recruiting	Intervention	2024-07-23	<NULL>	<NULL>	7148	Comparison of donated corneas with and without Descemet&apos;s membrane in deep anterior lamellar corneal transplantation with intraoperative perforation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-15	Hospital Oftalmológico de Sorocaba	Hospital Oftalmológico de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-52r82gy	<NULL>	Patients 18 years of age or older; patients indicated for  deep anterior lamellar keratoplasty (DALK) by the Hospital Oftalmológico de Sorocaba (HOS); patients who agree to participate in the study	Patients who do not present intraoperative perforation of the Descemet&apos;s membrane; patients requiring conversion to penetrating keratoplasty (PK); pregnant or breastfeeding woman; patients who at some point give up participating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-4bzxqjj	Comparative study of labor induction with Foley Tube for 24 hours and 48 hours in pregnant women with previous cesarean section	Recruiting	Intervention	2022-12-27	<NULL>	<NULL>	5778	Intrauterine Foley Catheter for 24 hours versus 48 hours for cervical ripening in pregnant with one previous cesarean section: randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-08	Guilherme Nicolau Camara	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4bzxqjj	<NULL>	One previous segmental cesarean section: medical recomendation for pregnancy interruption; Bishop score at 6 or least; single pregnancies with a term cephalic fetus	Premature rupture of membranes at the admission; non segmental previous uterine incision; suspicious fetal vitality; clinical suspicious for feto pelvic desproportion; patients that refuse to participate of the intervention; placenta pevia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-4h3xvg5	Comparative study of laser treatments for intraocular pressure control in patients with glaucoma	Recruitment completed	Observational	2021-08-31	<NULL>	<NULL>	4855	Comparative study of Selective Laser Trabeculoplasty versus Laser Micropulsed Trabeluloplasty for Intraocular Pressure Control in Patients with Primary Open Angle Glaucoma	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2016-07-07	RR Clínica Oftalmológica Ltda	União Metropolitana de Educação e Cultura	https://ensaiosclinicos.gov.br/rg/RBR-4h3xvg5	<NULL>	Primary Open Agle Patients on medical treatment (drops) in need to adjunctive intra-ocular pressure treatment to reach target pressure	Glaucoma patients with clinical diagnosis other than Primary Open Angle Glaucoma; advanced visual field defects; patients who had already undergone laser or fistulizing surgery for glaucoma control; history of ocular surgery within 6 months or prior laser to treatment or during 12-month follow-up period after the procedure; history of trauma and concurrent use of systemic or topical steroids and patients with corneal conditions precluding adequate laser treatment.  In cases where both eyes were eligible we included only eye with higher baseline intraocular pressure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-29nbjw	Comparative Study of Maxillary Bone Preservation after Dental Extraction with Different Biomaterials	Recruitment completed	Intervention	2018-10-10	<NULL>	<NULL>	2273	Comparative Study of Alveolar Border Preservation after Exodontia with Different Biomaterials	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-30	Universidade de Guarulhos	Universidade de Guarulhos	https://ensaiosclinicos.gov.br/rg/RBR-29nbjw	<NULL>	Individuals who sought the specialization clinic in Implant Dentistry of the University of Guarulhos and had indication of previous exodontia to the installation of implants osseointegráveis, with more than 20 years; good general health, requiring extraction of a maximum of 2 contiguous teeth in the maxilla, the teeth being condemned for periodontal reasons, root fracture, caries and unsuccessful endodontic treatment.	Individuals under 20 years of age; smoking; people with diabetes; carriers of blood dyscrasias; patients who use anticoagulants; pregnant women; infants; patients who had dental elements with active infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-10myxdss	Comparative study of self-report scales in cancer patients undergoing oral antineoplastic medications such as tyrosine kinase inhibitors	Not yet recruiting	Intervention	2022-11-07	<NULL>	<NULL>	5706	Use of the patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE) short version and MDASI in patients with Cancer patients submitted to oral antineoplastic medications such as Tyrosine Kinase Inhibitors: a comparative study of the 2 scales	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de São Paulo	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-10myxdss	<NULL>	older than 18 years; being treated with TKI alone as anticancer therapy, orally and for 3 months or more; being diagnosed with one of three cancers: kidney, lung, or chronic myeloid leukemia; Performance status between 0 and 2, evaluated according to the Eastern Cooperative Oncologic Group – ECOG scale	multiple comorbidities (3 or more), partial completion of one of the data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-75jyknx	Comparative study of the effect of Blood by-products and Tissue Grafts from the palate on the coverage of Exposed Roots in a single tooth	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7187	Comparative analysis of the efficacy of Blood Derivatives and Subepithelial Connective Tissue Grafting on Root Covering of single Gingival Recessions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-09	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-75jyknx	<NULL>	Patients at least 18 years old. Both genders. Must not have prior experience with procedures for root coverage. Diagnosed with type one (RT1) unitary gingival recession, measuring at least 1.5 mm in the presence of dentin hypersensitivity or 2 mm in its absence, with apical displacement of the gingival margin but no loss of interproximal bone tissue. Additionally, clinical detection of the cementoenamel junction on the mesial and distalsurfaces of upper or lower canines and/or premolars should not be possible. Absence of restorations or caries in the area to be treated. Healthy periodontium, characterized by probing bleeding &lt; 10%. Probing depth of 3 mm	Patients with systemic diseases that may interfere with healing or periodontal health (such as diabetes, hypertension, and blood disorders, among others). Users of anticoagulant or antiplatelet drugs. Users of orthodontic appliances. Users of fixed or removable prostheses involving the canines and/or premolar teeth with gingival recession were selected for the study. Smokers; pregnant or lactating individuals. Gingival recession defects associated with dental caries lesions. Teeth with evidence of pulp pathology, molars, or teeth with severe misalignment (rotation or extrusion). Cases that do not meet the aforementioned inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8jcwjp	Comparative study of the effect of the intervention of real Transcranial Led Therapy and placebo, on anxiety and depression with patients with TBI.	Recruiting	Intervention	2020-06-25	<NULL>	<NULL>	3953	Prospective randomized, double-blind, placebo-controlled study of the effects of the Transcranial Led Therapy Intervention (TLT) on anxiety and depression in patients with traumatic brain injury (TBI).	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Centro Universitário UniFacid	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8jcwjp	<NULL>	subject between 18 and 60 years old; ability to understand and follow instructions in Portuguese; Glasgow Coma Scale of entry equal to or greater than 12; TBI time from 3 months.	subjects under 18 or over 60; limiting language and / or motor impairment; non-signature of the informed consent form, presence of important bone defects in the regions of the skull to be stimulated, presence of epilepsy after uncontrolled TBI.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-8x7534h	Comparative study of the effectiveness of two mouthwashes in reducing gingival inflammation in hospitalized patients	Recruitment completed	Intervention	2023-12-19	<NULL>	<NULL>	6664	Comparative study of the efficacy of Chlorexidine and Chloramine T in Gingivitis reduction in patients admitted to a referral hospital in Ceará	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-07-07	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-8x7534h	<NULL>	Normosystemic patients; of both sexes; aged between 30 and 65 years; oriented and cooperative; with autonomy to promote self-care regarding oral hygiene and with a mouthing and spitting reflex; presenting gingivitis and admitted to a ward	Confirmed history of allergy to Chloramine T 0.2% and Chlorhexidine 0.12% or components of formulas; pregnant or breastfeeding women; presence of infections in the oral cavity; patients with impaired self-care; individuals with a history of adverse reactions to chlorhexidine or components of the formula; patients/guardians who did not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-48x3xv	Comparative study of the influence of blood flow, oxygenation and hemodynamics generated during the use of extracorporeal circulation machine	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	25	Comparison of the influence of two blood flow patterns generated by cardiopulmonary bypass pump in oxy-hemodynamic markers  during cardiopulmonary bypass	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Instituto Nacional de Cardiologia	Maria aparecida Nogueira de Lima Marcondes Salgado	https://ensaiosclinicos.gov.br/rg/RBR-48x3xv	<NULL>	Patient admitted to the National Institute of Cardiology,  which have coronary heart disease and were referred for surgery for isolated primary CABG, patients with ejection fraction greater than or equal to 45%, both sexes; aged between 18 and 75 years, during cardiopulmonary bypass use of vacuum-assisted venous drainage and use of normothermia during cardiopulmonary bypass	Patient admitted to the National Institute of Cardiology, which appear as disease and / or diagnosis associated with surgery, recent myocardial infarction (less than 3 months), recent stroke (less than 3 months, unstable angina, urgent or emergency surgery, diabetes mellitus decompensated - disease of diabetic ketoacidosis, renal failure - creatinine clearance &lt;30 ml / min	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6hywzn	Comparative study of the surgical treatment of Irreparable rotator cuff tears by the Augmentation associated with Interposition technique with fascia lata autograft versus Partial repair	Recruitment completed	Intervention	2018-09-17	<NULL>	<NULL>	4823	Comparative study of the surgical treatment of Irreparable rotator cuff tears by the Augmentation associated with Interposition technique with fascia lata autograft versus Partial repair	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo - SP- IAMSPE	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo - SP- IAMSPE	https://ensaiosclinicos.gov.br/rg/RBR-6hywzn	<NULL>	Age above 50 years; complex rotator cuff lesion (extensive and massive) diagnosed by radiographs, MRI and clinical examination; rotator cuff injury without history of traumatic event; pain and / or decreased shoulder strength for at least 3 months without improvement with conservative treatment; cooperative patients, who agree to participate in the research and sign the consent form.	Previous surgeries in the studied shoulder; patients smokers, chronic alcoholics, diabetics and non-collaborative; advanced arthrosis or arthropathy; rheumatological diseases or chronic use of corticosteroids; psychiatric disorders, fibromyalgia or chronic cervicobrachialgia; active infections; blood dyscrasias; neurological or vascular diseases in the affected limb; clinically decompensated comorbidities; hyperlipidemia and advanced osteoporosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-9hg547m	Comparative study of the treatment of fallen bladder with internal or external pessary	Terminated	Intervention	2022-03-17	<NULL>	<NULL>	5286	Comparative study of the treatment of pelvic organ prolapse with an internal or external pessary	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	University of São Paulo	University of São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9hg547m	<NULL>	Women with stage II pelvic organ prolapse (with point of greatest prolapse greater than 0) and III according to Pelvic Organ Prolapse Quantification System who agreed to participate in the study.	Cancer of the genitourinary tract;Post-menopausal genital bleeding;repeated urinary tract infection; short vagina; Recurrent genital infection; Impossibility of proper monitoring and maintenance of the pessary ;Contraindication to the use of estriol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-2dbpbjf	Comparative study of ways of positioning the head for computer planning of surgeries to correct facial deformities	Data analysis completed	Observational	2024-08-20	<NULL>	<NULL>	7237	Comparative study of head orientation methods using different software for virtual planning of orthognathic surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do RIo Grande do Norte	Universidade Federal do RIo Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2dbpbjf	<NULL>	Inclusion criteria were patients who were candidates for orthognathic surgery, including patients who underwent one- or multi-piece Le Fort one osteotomy, bilateral sagittal split osteotomy, and genioplasty, without significant asymmetries.	Exclusion criteria were patients undergoing temporomandibular joint (TMJ) reconstruction surgery, patients with TMJ pain, limited mouth opening and condylar resorptions, patients with any syndromic disorder, and patients with any lip and palate or facial cleft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-95gbvmq	Comparative study to assess the non-inferiority of single daily dosing Gentamicin and Metronidazole versus single daily dosing Gentamicin and three times a day Metronidazole in pediatric patients with Appendicitis	Recruiting	Intervention	2023-04-11	<NULL>	<NULL>	5991	Non-inferiority clinical trial of single daily dosing Gentamicin and Metronidazole versus single daily dosing Gentamicin and three times a day Metronidazole in pediatric patients with Appendicitis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-01-02	Instituto de Medicina Integral Professor Fernando Figueira	Hospital da restauração	https://ensaiosclinicos.gov.br/rg/RBR-95gbvmq	<NULL>	Patients under 14 years of age; patients admitted with a diagnosis of acute appendicitis and indication for appendectomy at Hospital da Restauração; exclusive antibiotic therapy with Metronidazole and gentamicin with an interval between the start of the antibiotic and the appendectomy of less than 24 hours; absence of associated infection	Immunocompromised patients; pregnancy; previous history of hypersensitivity, reaction, or allergy to metronidazole or gentamicin; patient with severe clinical picture: septic shock, preexisting severe comorbidity that influences (ASA III) postoperative recovery; after randomization, the patient will be excluded if: patients who present an allergic reaction to the administration of metronidazole or gentamicin; appendectomy without diagnostic confirmation during surgery; inadequate infectious source control in the surgeon&apos;s opinion; patients who strictly and exclusively adhere to one of the groups cannot be guaranteed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-9w5zzdh	Comparative study: Pericardio Bovino Vivendi versus native tissue in the treatment of pelvic prolapse	Recruiting	Intervention	2025-01-22	<NULL>	<NULL>	7675	&quot;Prospective, Randomized, Multicenter Comparative Study: Vivendi L-hydro - Labcor Graft versus Native Tissue in the Treatment of Pelvic Organ Prolapse in Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Municipal Maternidade -Escola Doutor Mário de Moraes Altenfelder Silva	https://ensaiosclinicos.gov.br/rg/RBR-9w5zzdh	<NULL>	Women. Age between 18 and 80 years. Report of an uncomfortable bulge in the vaginal area that the patients can feel or see. Pelvic Organ Prolapse grade 3 or higher, anterior, apical, and vault types. The patient or legally authorized representative must agree and provide written informed consent. Be literate. Have accepted the invitation and understood the information contained in the informed consent form. Participant capable and agreeable to follow the established follow-up regimen	Informed consent form. Patients who withdraw from the study. Active or chronic infection, including gynecological infection, urinary tract infection, or local tissue necrosis. History of pelvic organ cancer (uterine, ovarian, bladder, colorectal, or cervical). History of radiotherapy and/or chemotherapy in the pelvic region. Use of systemic steroids in the last month or immunosuppressive or immunomodulatory treatment in the last 3 months. Systemic connective tissue disease (Scleroderma, Systemic Lupus Erythematosus, Marfan Syndrome, Ehlers-Danlos Syndrome, Collagenosis, Polymyositis, Rheumatic Polymyalgia). Neurological disease with neurogenic dysfunction of the lower urinary tract (Multiple Sclerosis, Spinal Cord Injury, or Stroke). Previous prolapse surgery with mesh in the target compartment. Skeletal alteration that prevents positioning in lithotomy. Chronic pelvic pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-37f338	Comparative trial to evaluate the efficacy and safety of antibody treatment in patients with early breast cancer	Recruiting	Intervention	2015-01-12	<NULL>	<NULL>	370	A randomized, double-blind, phase 3 study evaluating the efficacy and safety of ABP 980 compared with trastuzumab in subjects with HER2 positive early breast cancer	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-05-01	Associação Hospital de Caridade Ijuí	Amgen Inc.	https://ensaiosclinicos.gov.br/rg/RBR-37f338	<NULL>	"Females equal or older than 18 years of age. Histologically confirmed invasive breast cancer. Planning for surgical resection of breast tumor and sentinel node (SN) or axillary lymph node resection. Planning neoadjuvant chemotherapy. HER2 positive disease defined as: 3+ overexpression by immunohistochemistry (IHC) or HER2 amplification by fluorescence in situ hybridization (FISH). 
Measurable disease (assessment method used in order of priority: ultrasound, mammography, MRI, or physical examination) in the breast after diagnostic biopsy, defined as longest diameter equal to or longer than 2.0 cm. Known ER and PR hormone receptor status at study entry. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Left ventricular ejection fraction (LVEF) of equal to or more than 55% by 2D echocardiogram. Normal bone marrow function as defined by: absolute neutrophil count (ANC) higher than 1.5 x 10^9 g/dL (1,500/microL); platelets higher than 100 x 10^9 g/dL (100,000/microL); hemoglobin higher than 10.0 g/dL. Normal hepatic function as defined by: total bilirubin within normal institutional limits; aspartate aminotransferase (AST) and alanine aminotransferase (ALT); lower than 2.5 × the upper limit of normal (ULN); subjects with an elevated unconjugated bilirubin (Gilbert&apos;s syndrome) will be eligible if hepatic enzymes and function are otherwise within normal limits (ie, AST, ALT, and Alkaline Phosphatase are within normal limits), and there is no evidence of hemolysis. Normal renal function as defined by creatinine lower than 1.5 × ULN or estimated creatinine clearance (CrCl) equal to or higher than 50 mL/min calculated by the Cockcroft- Gault method. 
Subjects must sign an IRB/EC-approved informed consent form before any study specific procedures."	Bilateral breast cancer. Presence of known metastases. Received prior treatment, including chemotherapy, biologic therapy, radiation or surgery with the exception of diagnostic biopsy for primary breast cancer. Other concomitant active malignancy or history of malignancy in the past 5 years except treated basal cell carcinoma of the skin or carcinoma in situ of the cervix. Pre-existing clinically significant (equal to or higher than grade 2) peripheral neuropathy. Any history of documented or current congestive heart failure, current high-risk uncontrolled arrhythmias, current angina pectoris requiring a medicinal product, current clinically significant valvular disease, current evidence of transmural infarction on electrocardiogram (ECG), or current poorly controlled hypertension. Severe dyspnea at rest requiring supplementary oxygen therapy. History of positivity for hepatitis B surface antigen, hepatitis C virus, or HIV. Recent infection requiring a course of systemic anti-infectives that were completed equal to or less than 14 days before enrollment (with the exception of uncomplicated urinary tract infection). Woman of childbearing potential who is pregnant or is breast feeding. Woman of childbearing potential who is not consenting to use highly effective methods of birth control (eg, abstinence, sterilization, birth control pills, Depo-Provera injections, or contraceptive implants) during treatment and for an additional 4 months after the last administration of the protocol specified treatment. Currently receiving treatment in another investigational device or drug study, or less than 30 days since ending treatment on another investigational device or drug study. Other investigational procedures while participating in this study are excluded. Subject has known sensitivity to any of the products to be administered during the study, including mammalian cell derived drug products, trastuzumab, murine proteins, or to any of the excipients. Subject previously has enrolled and/or has been randomized in this study. Subject likely to not be available to complete all protocol required study visits or procedures. History or evidence of any other clinically significant disorder, condition or disease (with the exception of those outlined above) that, in the opinion of the Investigator or Amgen physician, if consulted, would pose a risk to subject safety or interfere with the study evaluation, procedures or completion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-8gfdkg4	Compare helmet use during respirator use in patients with COVID	Not yet recruiting	Intervention	2021-08-12	<NULL>	<NULL>	4910	Comparison between the effectiveness of the Helmet interface through flow meters versus the mechanical fan for non-invasive ventilation in patients with Covid 19. Controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-24	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8gfdkg4	<NULL>	"Individuals over the age of 18 years with type I respiratory failure with a suspected or confirmed diagnosis of pneumonia caused by COVID-19 who meet all of the following criteria: Adequate level of consciousness, In oxygen therapy with FiO2 ranging from 45% to 81%, with worsening oxygen flow.
 PaO2 / FIO2 &lt;200 mmHg, PaCO2 equal to or less than 50 mmHg, Peripheral oxygen saturation (SpO2) &lt;93% with an offer greater than 6 l/min, Relative contraindication of severe H;  Hemodynamic stability"	"Patients who do not meet the inclusion criteria, who exhibit any absolute contraindication to the use of non-invasive mechanical ventilation and/or who exhibit the following conditions: Previous diagnosis of chronic obstructive pulmonary disease (COPD) with chronic CO2 retention or with its clinical characteristics according to the II Brazilian Consensus on Chronic Obstructive Pulmonary Disease of 2004,
Tracheostomy, patients with proportional therapy criteria (palliatives), patients in circulatory shock, hypoxemia not related to viral pneumonia, patients with severe signs of hypoxemia: the central cyanosis; the lowered level of consciousness or severe psychomotor agitation; the FR &gt; 35 and SpO2 &lt; 80%."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-9hhxqbs	Compare the cleaning effectiveness of teeth using Toothbrushes of Different Sizes and observe the presence of gingival fissures	Recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9020	Efficacy of Toothbrushes with Different Head Sizes in biofilm removal and evaluation of supragingival and gingival fissure inflammatory parameters: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-04	Faculdade de Odontologia da Universidade Federal de Pelotas / FO-UFPel	<NULL>	<NULL>	<NULL>	Individuals of both sexes, Individuals aged 18-65; Individuals willing to participate in all experimental periods of the study; Individuals with at least 20 natural teeth present; must not be participating in any other study or research; patients diagnosed with gingivitis; gingivitis will be defined as at least 30% of bleeding on probing determined at the initial consultation; patients with a minimum mean plaque index of 1,0	"Dental students; smokers; Individuals with uncontrolled hyperglycemia; pregnant and lactating women;
individuals with carious lesions; individuals with root remnants in the mouth; individuals diagnosed with periodontitis; periodontitis defined as interproximal attachment loss (IAL) ≥ 2 mm in non-adjacent teeth associated with probing depth (PD) ≥ 4 mm and bleeding on probing (BS) + (Papapanou et al., 2018); Individuals wearing removable partial dentures (RPDs); Individuals wearing fixed orthodontic appliances;
Individuals who have used anti-inflammatories and/or corticosteroids within 3 months of the experimental phase; Individuals who have used antibiotics three months prior to the present study; Individuals who have received dental prophylaxis or periodontal treatment in the last three months; Individuals who require antibiotic prophylaxis prior to dental procedure"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-3qyt32y	Compare the effects of Force Removal Maneuvers on Ventilatory Mechanics	Recruitment completed	Intervention	2023-06-21	<NULL>	<NULL>	6168	Comparative analysis of the effects of Higien Maneuvers Bronchial in Ventilatory Mechanics: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Secretaria de Estado da Saúde de Rondônia	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3qyt32y	<NULL>	Patients admitted to the ICU of AMI and CEMETRON hospitals; age above 18 years; presence of forte in the airways; Under the use of controlled mechanical ventilation; no ventilatory drive; No asynchronies; Intubated or tracheostomized Patients admitted to the ICU of AMI and CEMETRON hospitals; age above 18 years; presence of forte in the airways; Under the use of controlled mechanical ventilation; no ventilatory drive; No asynchronies; Intubated or tracheostomized	Hemodynamically unstable; who had a rib fracture; intracranial hypertension; bronchospasm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-7c4c5jx	Comparing Benzodiazepine-Ketamine and Benzodiazepine-Fentanyl sedation in Cataract surgery	Not yet recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7454	Comparison between Benzodiazepine associated with Ketamine versus Benzodiazepine associated with Fentanyl in Phacoemulsification	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-10-31	Hospital Oftalmológico de Brasília	Hospital Oftalmológico de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7c4c5jx	<NULL>	Patients undergoing phacoemulsification at HOBrasil, Salvador, Bahia; at least 18 years old; of both genders	Patients under 18 years of age; pregnant patients; patients with chronic pain syndrome; patients with hypersensitivity to any of the tested medications or the topical anesthesia used; patients with communication difficulties (significant hearing loss, speech impairments, aphasias); patients with physical status determined by the American Society of Anesthesiologists  classification of III-VI	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-943kwq	Comparing different techniques that may help epilepsy patients take their medicines	Recruitment completed	Intervention	2014-06-26	<NULL>	<NULL>	306	Compliance to drug therapy of Epilepsy patients	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-02-01	Escola de Enfermagem da Universidade de São Paulo	Cristina Helena Costanti Settervall	https://ensaiosclinicos.gov.br/rg/RBR-943kwq	<NULL>	Patients, from both genders, aged between 18 and 100 years-old, diagnosed with epilepsy in ambulatory care for over one year, with at least four years of school, independent in daily life activities, without mental and psychic disabilities, presenting  medium, or low adherence by the Morisky test.	Patients with medical prescription  with weekly or daily increase or removal of  anti-epileptic drugs,  including Carbamazepine, phenytoin, phenobarbital and valproate sodium; those that already use the resources tested in this trial to enhance compliance and with other chronic diseases in continuous  drug treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-84hbf5	Comparing the effect of Ibuprofen use and laser therapy on pain that occurs after canal treatment	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1759	Comparison of the effect of the use of Ibuprofen and the Photobiomodulation therapy on the postoperative pain in Endodontics: a controlled and randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-84hbf5	<NULL>	adult patients who already have indications for endodontic treatment in lower molar permanent teeth; Diagnosed with irreversible pulpitis; Have a contact phone number	Pregnant patients; Use of analgesic medication before treatment; Immunocompromised patients; Hypersensitivity to anti-inflammatories; Teeth with endodontic complications; Teeth unable to be treated in a single session; Patients unable to receive a call	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-63w5nz	Comparing the effect of two different movements systems on pain that occurs after canal treatment	Recruiting	Intervention	2018-05-22	<NULL>	<NULL>	1838	The incidence of postoperative pain after using a reciprocating system and a continuous rotary system: A prospective randomized clinical trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-63w5nz	<NULL>	Patient with physical status classified as ASA I (without systemic disorders) or II (with discrete to moderate systemic disorders) (American Society of Anesthesiologist / ASA); permanent teeth that require the need for endodontic treatment; presence or absence of periapical lesion; absence of symptomatology in the tooth to be treated; male and female gender; ages between 9 and 90 years; teeth with pulpal diagnosis: normal pulp, reversible pulpitis, asymptomatic irreversible pulpitis or pulp necrosis; teeth with apical diagnosis: normal apical tissue and with asymptomatic apical periodontitis	Pregnant patient; teeth with cracks or root fractures; patients who took pre-operative analgesic medication (in the last 24 hours), steroidal or non-steroidal anti-inflammatory and antibiotic (in the last 180 days); patients with periodontal disease; non-endodontic origin periapical lesion; previously accessed teeth; pre-filled teeth; teeth that need retreatment; teeth with pain palpation; teeth with vertical and / or horizontal pain percussion; teeth with spontaneous pain; teeth with mobility grade 2; internal or external resorption; teeth with incomplete rhizogenesis; apical obstruction of the root foramen	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-32g9wck	Comparing the treatment of Vulvar Condyloma, using two techniques: Laser and Electric.	Recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5039	Vulvar Acuminate Condyloma treatment: comparing surgical techniques using Diodo laser and Electrocaterization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-32g9wck	<NULL>	Volunteers; female. Attended in the gynecology outpatient with a clinical diagnosis (physical exam) of vulvar condyloma acuminata.	Volunteers suspected of having high-grade vulvar intraepithial lesion after physical exam. Volunteers suspected of vulvar cancer after physical exam. Volunteers diagnosed with Buschke-Löeenstein tumor. Volunteers with contraindication to locoregional or general anesthesia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-9k66x6	Comparing the use of Everolimus and Tacrolimus reduced dose versus Mycophenolate Sodium and Tacrolimus reduced dose in Liver Transplant patients	Recruiting	Intervention	2018-04-01	<NULL>	<NULL>	1695	Everolimo in combination with Tacrolimus low doses versus Mycophenolate Sodium gastro-resistant coated tablets with low doses of Tacrolimus in Liver Transplant recipients “de novo”	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-14	Hospital Geral de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-9k66x6	<NULL>	Orthotopic whole organ liver transplant recipients; deceased donor; age above 18 years; both sexes; with graft functionality within 72h of reperfusion.	Patients with pre-transplant protein and urinary creatinine ratio greater than 1mg / g or proteinuria 24h greater than 1g; multiple organ transplant recipients; patients with hypercholesterolemia (greater than 350 mg / dL) or hypertriglyceridemia (greater than 500 mg / dL) severe if use of lipid-lowering therapy with controlled hyperlipidemia will be accepted; previously transplanted liver patients who progressed with graft loss and in need of retransplantation; patients with positive serology for HIV; women who are pregnant, who are planning to become pregnant, are pregnant or breastfeeding, or do not agree to use effective methods of contraception; patients with difficult decision making who are not judged medically or mentally capable of providing informed consent on their own.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-4kpbhp	Comparing three drugs for reducing heart rate and blood pressure during laryngoscopy and intubation	Data analysis completed	Intervention	2020-03-20	<NULL>	<NULL>	3639	Comparative study of iv esmolol,iv diltiazem, and iv lignocaine hydrochloride in attenuating pressure response to laryngoscopy and intubation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-12	Government medical college haldwani	Government medical college haldwani	https://ensaiosclinicos.gov.br/rg/RBR-4kpbhp	<NULL>	"Patients equal to or greater than 18 years  and equal or lesser than  60 years of age;Patients weighing equal to or greater than 40kg and equal or lesser than 90 kgs of either sex  and BMI equal to or greater than 18.5  and equal or lesser than 24.9 of either sex;Patients posted for elective Surgical Procedure belonging to ASA physical status – 
Grade I and II;Patients requiring general Anesthesia and Endotracheal Intubation."	Patient / guardian refusal for consent;ASA grade III and IV;Emergency surgeries;Patients between age greater than 60 years and Age lesser than 18 years;Patients weighing greater than 90kg and lesser than 40kg  and BMI lesser than 18.5 and  greater than 24.9;Patients suspected to have difficult tracheal intubation;Patients on beta-blockers or calcium channel blockers;Patients with significant renal (serum creatinine greater than 1.5mg/dl) ,hepatic (serum total bilirubin greater than 1.2 mg/dl, serum total protein lesser than 6g/dl &amp; greater than 8.5g/dl ,serum albumin lesser than 3.5g/dl &amp; greater than 5g/dl , serum SGPT greater than 40u/l , serum SGOT greater than 56u/l) disease;Hypertensive patients systolic blood pressure greater than 160 mmHg and or diastolic blood pressure greater than 95 mmHg;Patients with chronic obstructive lung diseases especially bronchial asthma;Diabetic patients on treatment;Patients with significant heart disease like past history of  angina or myocardial infarction , heart blocks , and congestive cardiac failure;Laryngoscopy and intubation exceeding 20 seconds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-2c67h58	Comparing Treatments for bleeding control and palate healing after soft Tissue Graft removal	Recruitment completed	Intervention	2024-12-13	<NULL>	<NULL>	7587	Comparison of different hemostatic treatments and morbidity control and palate healing after soft tissue graft removal: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade Federal de Santa Catarina	Centro de Ensino e Pesquisa em Implantes Dentários	https://ensaiosclinicos.gov.br/rg/RBR-2c67h58	<NULL>	Patients over 18 years of age; of both genders; without significant systemic impairments in the preoperative phase; with good oral hygiene, defined by a plaque index of 25% or less; indicated for periodontal plastic surgery using a soft tissue graft; with no history of soft tissue removal from the palate	Patients with significant systemic disorders; those using anticoagulant or antiplatelet drugs; pregnant women; smokers; those with clinical and/or radiographic signs of periapical pathologies; untreated periodontal disease at the surgical site; individuals allergic to polymers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-3t7by45	Comparing treatments for fluid in the lungs: which is most effective?	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8624	CAPE-CHOICE: Comparative Results of Vasodilatory Strategies in Acute Pulmonary Edema	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Santa Casa de Misericórdia da Bahia	<NULL>	<NULL>	<NULL>	Patients with diagnosis of acute pulmonary edema in the emergency unit requiring vasodilator; age 18 years or older; both genders	Patients under 18 years of age; patients with cardiogenic shock; patients with acute coronary syndrome; patients with contraindication to any of the drugs; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-25k53m	Comparing two doses of Botulinum toxin A in the treatment of urinary symptoms	Data analysis completed	Intervention	2017-01-25	<NULL>	<NULL>	8080	A prospective randomized clinical trial comparing different doses of Abobotulinum toxin A in the treatment of Idiopathic Detrusor Overactivity	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2013-07-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-25k53m	<NULL>	Female partients; aged 18 years or older; diagnosis of idiopathic overactive bladder; refractoriness to treatment with behavioral measures and pharmacological therapy; or contraindication to the use of anticholinergics	Patients with cognitive deficit; extensive fibroids; tumors; grade III and IV prolapses; changes in bladder emptying, with high residue (above 150mL) or use of catheterization previously or repeat UTIs; predominant stress urinary incontinence; prior treatment with the toxin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-96nbqtm	Comparing Two Surgical Techniques for Treating Vitiligo: Blister Grafting versus Cell Suspension	Recruitment completed	Intervention	2026-02-18	<NULL>	<NULL>	8881	Comparative Study of Surgical Treatment of Vitiligo: Epidermal Grafting from Blisters versus Grafting of Uncultured Autologous Epidermal Cells Suspension Prepared in Blisters	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-27	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Patients with a clinical diagnosis of vitiligo, aged 14 years or older; Lesions stable for at least 12 months; Presence of symmetrical lesions in areas suitable for treatment; Availability to undergo narrowband ultraviolet B phototherapy sessions; Signed Informed Consent Form (ICF) and Image Use Authorization Form	Patients younger than 14 years of age; Patients who cannot undergo NB-UVB phototherapy for any reason; Unstable lesions or presence of Koebner phenomenon, confetti-like lesions, or trichrome lesions; Individuals with immunodeficiency, viral or bacterial infection, uncontrolled diabetes mellitus, blood dyscrasias, pregnant or breastfeeding women, or those who have used immunosuppressive medications within the past 30 days; Patients who have undergone phototherapy treatment within the past two months; History of photosensitivity or current use of photosensitizing medications within 30 days prior to initiating phototherapy; History of keloids, hypertrophic scarring, or tendency toward post-inflammatory hyperpigmentation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-7hsd9qj	Comparing two types of physical training and conditioning in patients with HIV/AIDS	Recruiting	Intervention	2025-12-02	<NULL>	<NULL>	8609	Efficacy and safety of a functional multimodal interval physical training protocol vs conventional training on physical function in hospitalized sarcopenic patients with HIV/AIDS: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-18	Instituto Nacional de Infectologia Evandro Chagas INI/FIOCRUZ	<NULL>	<NULL>	<NULL>	Age over 18 years; handgrip test with values greater than 27 KgF for men and less than 16 KgF for women and/or; five-repetition sit-to-stand test (STS5) longer than 15 seconds or inability to perform the test; walking speed less than or equal to 0.8 m/s; and two-minute stationary walk test (TM2) showing signs of low exercise tolerance; low exercise tolerance will be defined as subjective perception of effort by BORG scale greater than or equal to 3 and/or signs of respiratory discomfort (nasal flaring, intercostal retraction) and/or drop in peripheral oxygen saturation (SpO2) less than or equal to 90% during the test, according to the guidelines of the American College of Sports Medicine.	Patients over 60 years old; use of supplemental oxygen less than 5 L/min; refusal to undergo assessment tests; hemodynamic and ventilatory instability; states of catabolism: SIRS, sepsis, symptomatic anemia, among others; osteomyoarticular and/or neurological injury; general condition of physical or mental deterioration that prevents patient cooperation; muscle strength grade less than or equal to 2 in any limb evaluated by the Medical Research Council scale	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-8mng33	Comparision between Hardinge and Minimally invasive aproaches for Hip fractures treatment using Dynamic Hip Screw	Recruitment completed	Intervention	2018-11-26	<NULL>	<NULL>	2347	Comparision between Hardinge and Minimally invasive aproaches for Intertrochanteric fractures treatment using Dynamic Hip Screw	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-26	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8mng33	<NULL>	"Been brazilian
60 years old or older
Any gender
Patients with intertrochanteric fracture in codition approprated to the proposal surgical procedure
Patients that authorize their participation through the signing of the consent form"	"Patients who declared themselves indian;
Patients with intertrochanteric fractures with obliquity reverse fracture, whose treatment with DHS is not recommended;
Patients with pathological intertrochanteric fractures due to malignant or benign tumor disease;
Cases in which the anesthesia team refused to perform the intraoperative analgesia protocol chosen for the study;
Patients who needed blood transfusion in the immediate trans or postoperative period;
Patients with low level of discernment, to answer the pre and postoperative questions, of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-4z9wdg	Comparison among two drugs commonly used in the prevention and treatment of thrombosis, to prevent thromboembolism after total cavopulmonary operation.	recruitment completed	Intervention	2012-03-07	<NULL>	<NULL>	154	A comparative study of oral anticoagulants and antiplatelet prophylaxis of thrombosis and thromboembolic events in the Fontan operation using extracardiac conduit.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-31	Hospital do Coração da Associação do Sanatório Sirio	Hospital do Coração da Associação do Sanatório Sirio	https://ensaiosclinicos.gov.br/rg/RBR-4z9wdg	<NULL>	"Scheduling total cavopulmonary operation according to the clinical criteria for surgery.
 Parents or guardians agree to the inclusion in the study."	Patients with contraindications to receive any of the medications (sodium warfarin or aspirin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-5j3h3c	Comparison between 2 and 5 minutes of  stretching in the calcaneus tendon	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2044	Comparison between 2 and 5 minutes of passive static stretching in the mechanical properties of the calcaneus tendon in young adults: a clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5j3h3c	<NULL>	Be between 18 and 40 years old;To be physically active, but not engaged in strength training and flexibility according to the classification of the International Physical Activity Questionnaire (IPAQ)	Do not compare with evaluations (pre or post);Withdraw your consent;Have two consecutive fouls or three interspersed without a stretching program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-2ss7yy8	Comparison between a biomaterial and autogenous graft in the treatment of gingival recessions. Randomized controlled clinical trial	Recruitment completed	Intervention	2025-09-17	<NULL>	<NULL>	8285	Comparison between porcine acellular dermal matrix and subepithelial connective tissue graft in root coverage of gingival recessions. Randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-05	Universidade de São Paulo	Faculdade de Odontologia de Ribeirao Preto da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2ss7yy8	<NULL>	Both sexes; minimum age of 18 years; with bilateral Class I or II Miller unilateral gingival recessions greater than or equal to 3 mm in non-molar teeth; main complaint of aesthetics or unresolved dentin hypersensitivity	Systemic health compromise; contraindication for periodontal surgery; smokers; pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-2k94bn	"Comparison between Active Heat and Passive Heat Associated with Training
Posterior musculature flexibility passive"	Recruitment completed	Intervention	2020-01-28	<NULL>	<NULL>	3415	"Comparison between Active Heat and Passive Heat as Supporting in Training
Hamstring flexibility passive: randomized controlled trial"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-07	Universidade de Ciências da Saúde de Porto Alegre-UFCSPA	Universidade de Ciências da Saúde de Porto Alegre-UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-2k94bn	<NULL>	Active young women 18 to 30 years of age with restricted range of motion who had knee extension amplitude less than or equal to 160 degrees and hip flexion range less than or equal to 80 degrees	Previous neurological, muscular or joint disease that influences training performance; previous lower limb surgery; presence of painful symptoms or edema in the lower limbs; have hypersensitivity to heat application; Raynaud&apos;s syndrome; loss of local thermal sensitivity; have metal implants; use of cardiac pacemaker; presence of malignant tumor; arterial diseases; deep vein thrombosis or phlebitis; fever and inflammatory processes; bleeding processes; osteomyelitis; epilepsy; pulmonary and bone tuberculosis; kidney or urinary tract infection. Also excluded were subjects who had a training attendance lower than 85%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-5j7m4gk	Comparison between aerial silk and artistic gymnastics in the physical development of children	Recruitment completed	Intervention	2026-03-12	<NULL>	<NULL>	8969	Feasibility of aerial silk intervention on physical performance and movement function in children: a blinded, non-randomized controlled trial	<NULL>	n/a, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Faculdade de Educação Física e Fisioterapia	<NULL>	<NULL>	<NULL>	Age between 7 and 14 years old; Be duly enrolled in the aerial silks and/or artistic gymnastics classes linked to Dance program, circus activities and gymnastics; Have a minimum attendance of 90% in their respective classes.	Participants who present with any musculoskeletal injury during the evaluation period, who have any medical contraindication, or who have not completed all stages of the evaluation will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-92wcttd	Comparison between Ceftriaxone and Crystalline Penicillin for the treatment of Ocular Syphilis	Recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7882	Ceftriaxone versus Crystalline Penicillin for the treatment of ocular Syphilis: a randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital de Clínicas da UNICAMP	Hospital de Clínicas da UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-92wcttd	<NULL>	Individuals, male or female; over 18 years of age diagnosed with ocular syphilis	History of previously treated syphilis; allergy to penicillin or cephalosporin; immunocompromised individuals not infected with the Human Immunodeficiency Virus (HIV); concomitant severe eye disease that may compromise the analysis of response to treatment of syphilis uveitis (e.g., diabetic macular edema, age-related macular degeneration, previous blindness for other reasons); refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-33jxjcr	Comparison between Classical and Modified Mandibular Osteotomy. A Randomized Clinical Trial	Recruiting	Intervention	2025-08-15	<NULL>	<NULL>	8209	Comparison between Conventional and Modified Sagittal Split Osteotomy of the Mandibular Rami	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital Universitário Oswaldo Cruz	Hospital Universitário Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-33jxjcr	<NULL>	Patients with facial Pattern II or the sagittal component of Pattern II; Patients who sought outpatient care for the reported problem at Oswaldo Cruz University Hospital; Be at least 18 years of age. Individuals of both sexes will be included in the sample.	Patients who have not signed the consent form or with: Incomplete documentation; Trauma sequelae; Craniofacial syndromes; Disabling systemic comorbidities; In treatment of OSAS through other modalities; Presence of an impacted, impacted or out-of-occlusion third molar; Need for reoperation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-72f23t	Comparison between comic book and verbal information about surgery in the anxiety of parents and children in the preoperative period	Recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3722	Educational intervention through a comic book on anxiety of parents and children in the preoperative period: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-14	Faculdade de Medicina de Botucatu - Departamento de Enfermagem	Faculdade de Medicina de Botucatu - Departamento de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-72f23t	<NULL>	"CChildren
Children aged 6 to 14 years. Physical status ASA I and II according to the classification of the American Society of Anesthesiologists (ASA). With elective surgery scheduled for up to 04 hours in duration.

Parents: be 18 years or older. Be literate and communicate verbally."	"Children
Children with neuropsychomotor deficit and using psychoactive drugs. With hearing and / or visual impairment. Using pre-anesthetic medication. Hospital stay longer than 07 days.
Parents
Exclusion Criteria: Not having accompanied the child since admission to the operating room."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-96jrm5	Comparison between conventional physical therapy and Pilates&apos; Method in the evolution of functionality, respiratory muscle strength and exercise capacity in hospitalized chronic renal patients	Recruiting	Intervention	2013-09-01	<NULL>	<NULL>	241	Effectiveness of conventional physical therapy and Pilates&apos; method in functionality, respiratory muscle strength and ability to exercise in hospitalized chronic renal patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-09	UNIVERSIDADE CIDADE DE SÃO PAULO	Hospital do Rim e Hipertensão	https://ensaiosclinicos.gov.br/rg/RBR-96jrm5	<NULL>	No acute neuropathy or lung disease, or also rheumatic and orthopedic diseases associated that prevent them from performing the proposed protocol; those who have cognitive ability to respond to the questionnaire and ability to ambulate.	Will be excluded immediate postoperative abdominal surgery, from the upper or lower abdomen; those who present, at the time of hospitalization, the need for use of noninvasive mechanical ventilation and intubation; those who present thrombocytopenic; those with diagnosis of deep vein thrombosis and who require intensive medical support	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-9m3bsb	Comparison between conventional surgery reduction and radiofrequency ablation in the treatment of nasal obstruction	Recruiting	Intervention	2019-07-18	<NULL>	<NULL>	2821	Comparison between conventional partial inferior turbinectomy and radiofrequency ablation in the treatment of inferior turbinate hypertrophy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Faculdade de Medicina da Universidade de São Paulo	Supri	https://ensaiosclinicos.gov.br/rg/RBR-9m3bsb	<NULL>	"Nasal obstruction secondary to inferior turbinates hypertrophy.
Patients older than 12 years.
No satisfactory response to medical treatment with topic corticoesteroids and nasal saline irrigation for at least three months."	"Obstructive nasal septum deviation (Cottle classification grade 2 or 3 or anterior deviation).
Previous nasal surgery (except adenoidectomy).
Intolerance to procedures performed under local anesthesia.
Patients with multiple comorbidities, classified as ASA 3 or superior."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-7g5s66	Comparison between Custodiol®, del Nido, and modified del Nido in myocardial protection – CARDIOPLEGIA Trial: a randomized double-blind clinical trial	Recruiting	Intervention	2020-07-06	<NULL>	<NULL>	4746	Comparison between Custodiol®, del Nido, and modified del Nido in the myocardial protection – CARDIOPLEGIA Trial: a randomized double-blind clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-07-15	Hospital Nossa Senhora da Conceição	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-7g5s66	<NULL>	Patients referred for elective valve replacement surgery or coronary artery bypass grafting surgery (CABG) with cardiopulmonary bypass, aged at least 18 years, accordance with the Free and Informed Consent Form, will be enrolled.	Patients with chronic renal disease (previous medical diagnosis or serum creatinine greater than 1.5 mg/dL), previous cardiac surgery, severe psychiatric illness, or inability or unwillingness to give informed consent for participation will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-8cb56q	Comparison between debriefing techniques for support diagnostic reasoning in nursing students	Not yet recruiting	Intervention	2019-10-07	<NULL>	<NULL>	3038	Debriefing techniques as a help tool for diagnostic  reasoning of nursing students  randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-05	Marcella Ferroni Gouvea	Marcella Ferroni Gouvea	https://ensaiosclinicos.gov.br/rg/RBR-8cb56q	<NULL>	Students registered in the second year of undergraduate Nursing course at the Federal University of Viçosa; and which are studying the discipline &quot;Nursing Skills II; both sexes; age  18 years old	It will be excluded from this study, students with training in other higher or technical courses in health; those who already have skill as a professional in the preparation of nursing diagnoses; who do not accept to participate in this research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-58m7f6	Comparison between different methods of root canal treatment in children.	Recruiting	Intervention	2020-04-06	<NULL>	<NULL>	3709	Pulpectomy versus non-instrumental endodontic treatment in deciduous teeth: randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-21	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-58m7f6	<NULL>	Posterior teeth with deep caries lesions and associated interradicular and / or periapical radiolucency; teeth affected by caries with abnormal mobility due to periapical pathology, but not associated with physiological exfoliation; history of spontaneous pain; teeth presenting intraoral swelling or drainage of the sinus tract; continuous bleeding after amputation of the coronal pulp tissue; and teeth with external physiological or pathological resorption involving less than a third of the root length.	Systemic pathology (clinically compromising conditions and special health care needs); history of allergic reaction to local anesthetics or to the components of the test materials; antibiotic therapy in the 30 days prior to the intervention or during treatment; teeth unable to receive absolute isolation and / or unable to be restored; tooth that has previously undergone root canal manipulation; tooth with interradicular or periapical radiolucency involving more than half of the smallest vertically measured root; tooth with internal root resorption; tooth with physiological or pathological external root resorption of more than one third of its length; root canal obliteration; or inadequate bone support evidenced by non-physiological tooth mobility compared to the contralateral tooth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-8qkx34	Comparison between different methods of strength training on muscle adaptations and functional performance in older women	recruitment completed	Intervention	2012-11-13	<NULL>	<NULL>	105	Comparison of methods for determining the load and speed of executation of strength training on neuromuscular adaptations and performance of functional perfomance in older women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Federal do Rio Grande do Sul	Faculdade da Serra Gaúcha	https://ensaiosclinicos.gov.br/rg/RBR-8qkx34	<NULL>	Women aged between 60 and 75 years. Not strength training practitioner at least 12 months. Not practicing regular exercise with weekly frequency equal to or exceeding twice. Low to moderate levels of physical activity. Apparently healthy, without involving the neuromuscular system, cardiovascular and endocrine. Medical certificate agreeing with the practice of strength training. Lack of use of any medication with influence in the neuromuscular system.	Change in health condition established by medical certificate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-5t95n5	Comparison between different types of exercises to strengthen in patients with osteoarthritis of the knee	Data analysis completed	Intervention	2013-07-15	<NULL>	<NULL>	3044	Effect of strength training in different kinetic chains in pain, quality of life, the pattern of muscle recruitment during ascent and descent of stairs and joint position sense in patients with osteoarthritis of the knee	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-20	Universidade Federal de Uberlândia	Fundação de Apoio Universitário	https://ensaiosclinicos.gov.br/rg/RBR-5t95n5	<NULL>	Individuals of both sexes between 50 and 80 years, which presented diagnosis of osteoarthritis (OA) according to the criteria of the American College of Rheumatology, accompanied by radiological evidence, affecting one or more compartments of the knee, at the mild or moderate, with knee pain for six months or more and bilateral involvement.	Participants will have other musculoskeletal changes, chronic inflammatory diseases such as autoimmune diseases (rheumatoid arthritis, lupus, etc), diabetes mellitus, and neuromuscular disorders such as Parkinson&apos;s disease, vertigo and other conditions that may affect the sensory and control of movement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-5g9j7k	Comparison between dry land and aquatic physical therapy effects on physical activity and other clinical variables in asthmatic children	Data analysis completed	Intervention	2020-11-05	<NULL>	<NULL>	7715	Comparison between aquatic and dry land physical training on exercise capacity and other clinical outcomes in asthmatic children: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-09	Universidade Norte do Paraná - UNOPAR	Universidade Estadual de Londrina - UEL	https://ensaiosclinicos.gov.br/rg/RBR-5g9j7k	<NULL>	Asthmatic children between 7 and 11 years old; both genders; clinically medicated and stable; recruited through active search in schools; able to perform all of the study procedures	Presence of comorbidities that could prevent performance assessment and intervention procedures; history hospitalization and/or pneumonia 3 months before and during the study; have previous participation in any complementary pulmonary rehabilitation treatment in the last 6 months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-696vpmn	Comparison between Dry needling and Percutaneous microelectrolysis techniques for Low back pain	Recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8436	Comparison between Dry needling and Percutaneous microelectrolysis techniques on muscle Trigger points in the lumbar spine	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-07	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-696vpmn	<NULL>	Participants aged 18 to 60 years; Both genders; Clinical diagnosis of nonspecific chronic low back pain; Period of more than 6 months with pain with tender points in the lower back on palpation	Neurological symptoms; Loss of strength; Loss of sensitivity; Loss of osteotendinous reflexes; Pain following an anatomical nerve path; Pain below the knee; Pacemaker; Neoplasms; Allergic to metals; Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-78y8prn	Comparison between electrical stimulation of the muscle with needles and electrical stimulation of the muscle with electrodes to prevent loss of strength and muscle in severe adult patients hospitalized in the Intensive Care Unit.	Recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6386	Comparison between neuromuscular electrostimulation by acupuncture and neuromuscular electrostimulation conventional in the prevention of muscle mass loss in critical adult patients hospitalized in intensive care unit: a simple blind randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Alex Blank de Paula	Silvia Ataides Alves Santana	https://ensaiosclinicos.gov.br/rg/RBR-78y8prn	<NULL>	Volunteers who give consent to participate in the research with the signature of the consent form by the legal guardian for the patient to participate in the research, both genders, age between eighteen and fifty years, time of use of Invasive Mechanical Ventilation less than twenty-four hours in the first evaluation, not be previously bedridden,; have no confirmed or suspected diagnosis of neuromuscular disease.	Volunteers who evolve with death, extubation or transfer after having started the protocol less than three days ago, and volunteers in whom the family withdraws consent to participate in the research at any time.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-29r8nr	Comparison Between Erector Spinal Plane Blocking Techniques versus Epidural Block for Postoperative for pain treatment in Open bladder surgeries	Recruitment completed	Intervention	2019-03-26	<NULL>	<NULL>	2757	Comparison Between Erector Spinal Plane Blocking Techniques versus Epidural Block for Postoperative Analgesia in Open Cholecystectomies: A Randomized Clinical Trial.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-12-03	Universidade do Sul de Santa Catarina	Sianest Servicos Integrados de Anestesiologia	https://ensaiosclinicos.gov.br/rg/RBR-29r8nr	<NULL>	patients over 18 years of age; ASA class I and II; undergoing elective open cholecystectomy with Kocher incision	patients requiring indication of emergency / emergency cholecystectomy; need for intraoperative cholangiography; need for posterior biliary manipulation; ASA III or higher patients; history of allergy to any study medication; use of anticoagulants; use of anticonvulsants; and deficit postoperative cognitive impairment that prevented the patient from understanding / responding to the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-2n5b5y3	Comparison between Femoral Nerve Anesthesia and Adductor Canal Anesthesia in analgesia and mobility in patients undergoing Revision knee prosthesis surgery randomized controlled clinical trial	Data analysis completed	Intervention	2024-08-08	<NULL>	<NULL>	7189	Comparison between Femoral Nerve Block and Adductor Canal Block in analgesia and mobility in patients undergoing Revision total knee Arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-25	Ministério da Saúde	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-2n5b5y3	<NULL>	Patients undergoing total knee arthroplasty revision surgery; both sexes; older than 18 years; classified by the American Society of Anesthesiology (ASA) as physical status I to III	Patients with daily consumption of opioids and/or antidepressants; patients in whom it was necessary to perform general anesthesia; patients with neurological and muscular diseases; patients allergic to dipyrone, tramadol and local anesthetics; bedridden and amputated patients; and patients with grade III obesity (BMI &gt; 40)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-668c8v	Comparison between High Intensity Interval Training and Strenght Training on Blood Vessel Health and Exercise Tolerance in Heart Failure	Data analysis completed	Intervention	2018-05-21	<NULL>	<NULL>	4640	Comparison  of High Intensity Interval Training versus Circuit Resistance Training on Endothelial Function and Oxygen Uptake Kinects in Heart Failure: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Faculdade de Ceilândia da Universidade de Brasília	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-668c8v	<NULL>	Heart failure with reduced and preserved ejection fraction; both sexes; age greater than or equal to 35 years; sedentary in the last 6 months; non smokers. The regular medications accepted will only be used to control cardiovascular factors required by a cardiologist	Joint problems; respiratory diseases; inflammatory or infectious process; tendon or osteoarticular muscle injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-2sh88b	Comparison between Himalayan salt and common salt in urinary sodium values and blood pressure of hypertensive individuals	Recruitment completed	Intervention	2020-08-29	<NULL>	<NULL>	4187	Comparison between Himalayan salt and common salt in urinary sodium values and blood pressure of hypertensive individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Faculdade de Medicina da Universidade Federal de Goiás	Faculdade de Medicina da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2sh88b	<NULL>	Women; Age between 40 and 60 years; Diagnosis of essential hypertension, stable blood pressure and no change of medications in the last 60 days.	Decompensated heart failure; Stroke in the last 6 months; Acute myocardial infarction less than 3 months old; Decompensated diabetes (glycated hemoglobin above 8) liver disease characterized by transaminase values 3 times higher than reference value; Hypothyroidism; Renal disease, with a glomerular filtration rate lower than 60mL / min / 1.73m2SC; Illicit drug users; Alcoholics (more than 1 dose / day for women and 2 doses / day for men) 1; Patients with uncontrolled psychiatric disorders; Patients with medication change in the last 60 days and / or during the intervention; Patients who eat their meals in places where they can not prepare them with the salt of this study more than once a week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-8qcgzxw	Comparison between infiltration with Hyaluronic Acid and Corticosteroid in the joint in the treatment of chronic low back pain: clinical study	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7677	Comparative study between Hyaluronic Acid and Corticosteroids in facet joints in the treatment of chronic low back pain: randomized clinical study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital e Maternidade São Domingos	Hospital e Maternidade São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-8qcgzxw	<NULL>	Both genders; older than 18 years; with chronic low back pain for more than 3 months; with pain intensity greater than 4 on the visual analogue pain scale; no radicular pain; caused by degeneration of the facet joint and which presents relief after test block	Trauma patients; neurological deficits; infection at the puncture site; cognitive impairment; psychiatric illness; hypersensitivity to medications; use of anticoagulants; coagulopathy and pregnant women will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-8p484w	Comparison between Internal Jugular Vein versus Axilar Vein for implantable ports	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1521	Internal Jugular vein versus Axilar Vein with single-incision for Implantable Ports: a prospective and randomized study	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-04-17	AC Camargo Cancer Center	AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-8p484w	<NULL>	Minimum age 18; cancer patients; only catheter for chemotherapy; ECOG (performance status) from 0 to 2; signed informed consent form.	Non compliance; anticoagulant therapy; coagulopathy (platelet count below 50,000 and/or protrombin time above 18s); death within 30 days after the procedure; another catheter in superior vena cava; previous long term catheter in superior vena cava; obesity (IBM&gt;40 Kg/m2).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-54g48y	Comparison between intravenous Methadone and Morphine on the quality of anesthesia recovery after stomach reduction surgery	Data analysis completed	Intervention	2019-02-01	<NULL>	<NULL>	3512	Effect of intravenous Methadone compared to Morphine on the quality of anesthesia recovery after laparoscopic gastroplasty surgery: prospective, randomized and controlled clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-01-21	Financiamento próprio.	Financiamento próprio.	https://ensaiosclinicos.gov.br/rg/RBR-54g48y	<NULL>	Patients included in the study protocol should meet the following criteria: age between 18 and 65 years; body mass index (BMI) &gt; 40 kg / m2 regardless of the presence of comorbidities or BMI between 35 and 40 kg / m2 in the presence of comorbidities; framed in the ASA (American Society of Anaesthesiologists) from I to III; submitted to videolaparoscopic gastroplasty surgery under general anestesia; expected hospital stay of up to 36 hours.	It will be excluded from the study protocol the patients who: refuse to participate of the proposed study; have history of adverse reactions to any drug included in the study protocol; have history of alcohol or illicit substances abuse; are chronic users of opioids for various reasons; have hepatic or renal failure; need for conversion from laparoscopic surgery to laparotomy; concomitant surgical approach on other surgical site; have the presence of coexisting diseases that impair cognitive ability; have the presence of poorly controlled psychiatric illnesses; and have retarded neuropsychomotor development.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-9j767y	Comparison between Laser Acupuncture Versus Medications in Pain Reduction after Wisdown Tooth Removal	Recruiting	Intervention	2020-04-27	<NULL>	<NULL>	3774	Evaluation of the Effect of Laser Acupuncture on Pain and Edema after Extraction of Impacted Lower Third Molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Departamento de Odontologia da Faculdade de Ciências da Saúde da Universidade de Brasília	Instituto de Gestão Estratégica do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-9j767y	<NULL>	Age equal to or greater than 18 years; general good health (ASA I or II); indication of bilateral extraction of included third molars (intraosseous inclusion) under similar conditions on both sides and requiring ostectomy for their removal	Use of any analgesic medication in the last 15 days; pregnant women; lactating; when there is presence of pericoronaritis related to the lower third molar; individuals with a history of allergies or adverse effects to the drugs used in the study; individuals who have already undergone previous acupuncture treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-9wyk6t4	Comparison between Laser Cryosclerotherapy and Sclerotherapy in Varicose Vein treatment: success rate and side effects	Recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7702	Randomized clinical trial comparing the CLaCS technique and Sclerotherapy for the treatment of Superficial Venous Disease of the lower limbs: comparing success rate and side effects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade do Vale do Rio dos Sinos	Clinica Prime Vascular	https://ensaiosclinicos.gov.br/rg/RBR-9wyk6t4	<NULL>	Women; aged between 18 and 70 years; reticular veins and telangiectasias; without reflux of the deep venous or saphenous system; Fitzpatrick Skin Type I, II or III; Patients should have at least one reticular vein with a minimum length of 5 cm in one of the lower limbs on the lateral side of the thigh	Venous disease CEAP class greater than C1; who underwent procedure with sclerotherapy or transdermal laser in the last 12 months; skin classification Fitzpatrick IV, V or VI; pregnancy or puerperium; known allergy; peripheral arterial disease; diabetes; dermatitis at the treatment site; asthma; migraine; deep or superficial deep vein thrombosis (DVT); family history of DVT; known thrombophilia or any hypercoagulable state and use of anticoagulants; uncontrolled systemic disorders; patients who fail to attend their treatment sessions or follow-up visits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-5rhp9j	Comparison between Lumbar Quadrant Blockade and Morphine made in Spinal Anesthesia for pain reduction after cesarean section	Recruiting	Intervention	2019-08-27	<NULL>	<NULL>	2898	Comparison between Lumbar Quadrant Blockade and intrathecal Morphine for postoperative analgesia in Cesarean Section	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5rhp9j	<NULL>	The inclusion criteria will be: ASA I and ASA II patients; with gestational age of at least 37 weeks; normal and single gestation,age between 18 and 60 years.	Os critérios de exclusão serão: inabilidade de compreender ou verbalizar a escala de avaliação da dor;  coagulopatias congênitas; anormalidades anatômicas e infecção localizada.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-55zwb45	Comparison between measurements the Peripherally Inserted Central Catheter in children and newborns	Recruiting	Intervention	2025-01-15	<NULL>	<NULL>	7663	Comparison between two methods of measuring the Peripherally Inserted Central Catheter in pediatric and neonatal patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-17	Escola de Enfermagem - Universidade Federal de Minas Gerais	Hospital Metropolitano Odilon Behrens	https://ensaiosclinicos.gov.br/rg/RBR-55zwb45	<NULL>	Neonates and children aged to 12 years (ver emenda); both genders; with Peripherally Inserted Central Catheter - PICC Insertion procedure in upper limbs; who agree to participate in the study	Peripherally Inserted Central Catheter insertion procedure in lower limbs, external jugular veins and temporal and auricular veins; procedures performed in patients with congenital anomalies that present variations in the venous network or displacement of the anatomical location of the heart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-2rx6k6p	Comparison between methods for blocking the dental occlusion during surgeries for fixation of facial fractures	Recruitment completed	Intervention	2022-08-11	<NULL>	<NULL>	5545	Comparison between intermaxillary fixation methods in maxillofacial fractures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-28	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Santa Casa de Caridade de Diamantina	https://ensaiosclinicos.gov.br/rg/RBR-2rx6k6p	<NULL>	Patients diagnosed with facial fractures involving dental occlusion requiring IMF admitted at Santa Casa de Caridade de Diamantina; patients older than 18 years old; healthy patients according to their medical history and physical examination.	Patients diagnosed with complex facial fractures that it would be impossible to evaluate the variables/outcomes; patients with metabolic diseases; toothless patients or those lacking 5 or more posterior teeth; patients in whom it is not possible to achieve intraoperative dental occlusion; patients with history of previous mandibular  fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-57v9mrb	Comparison between models of resistance training volume progression on strength and muscle mass	Not yet recruiting	Intervention	2022-11-10	<NULL>	<NULL>	5719	Comparison of volume load progression models in Resistance training in strength gains and muscle hypertrophy: a within-subject randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-23	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-57v9mrb	<NULL>	Healthy young people; both sexes; age between 18 and 35 years	Have practiced resistance training in the last 6 months; Musculoskeletal injury of lower limbs; neuromuscular disorders that may prevent the execution of the protocols proposed by the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-4vwy5xj	Comparison between moderate load Exercises and high load Exercises in the rehabilitation of runners with Achilles Tendon Pain	Recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7250	Exercises with different intensities for rehabilitation of runners with Achilles Tendinopathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-15	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4vwy5xj	<NULL>	Amateur runners aged 18 to 60; male; with a clinical diagnosis of tendinopathy of the middle portion of the Achilles tendon	Exclusively insertional Achilles tendinopathy; washout period of less than 4 weeks from other treatments; use of corticosteroid injections in the Achilles tendon region or use of fluoroquinolone antibiotics in the last 12 months; other injuries to the affected lower limb in the last 3 months; musculoskeletal surgery on the spine or lower limbs in the last 12 months; history of Achilles tendon rupture and systemic diseases that may interfere with rehabilitation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-9hw4vbs	Comparison between Myofascial Release Instruments in reducing muscle pain in runners	Recruitment completed	Intervention	2023-01-30	<NULL>	<NULL>	5847	Comparison between Instrumental Myofascial Release Devices in relieving delayed muscle pain in runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-19	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9hw4vbs	<NULL>	Healthy volunteers; both genders; age between 18 and 49; who have been running for more than 6 months	Participants who are using analgesics; pregnant or postpartum women; with active infectious processes; inability to understand instructions or consent to the study; with the presence of auditory, visual or communication disorders; who have moderate or severe cognitive/psychiatric disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-5z6dxkr	Comparison between normal diet and special diet for Diabetes in controlling blood sugar level in critically ill patients	Not yet recruiting	Intervention	2024-06-05	<NULL>	<NULL>	7050	Comparison between standard formula and specialized formula for Diabetes in glycemic control in critically ill patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-06-30	Centro Universitário do Espírito Santo - UNESC	Hospital e Maternidade São José - HMSJ	https://ensaiosclinicos.gov.br/rg/RBR-5z6dxkr	<NULL>	Adult and elderly patients - minumum age 18 years old; on invasive mechanical ventilation; of both sexes; who present hyperglycemia (blood glucose ≥180 mg/dl) in the first 72 hours after hospitalization	Patients already admitted to palliative care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-99jmmpf	Comparison between Orientation and Hiking Modalities in healthy aged	Recruiting	Intervention	2021-06-25	<NULL>	<NULL>	4763	Comparison between the effectiveness of Orienteering and Hiking Modalities in Physical and Cognitive Capacities and in the Quality of Life of independent aged	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-31	Pontifícia Universidade Católica do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-99jmmpf	<NULL>	Independent elderly volunteers aged 60 or over; male and female; residents of Porto Alegre; who do not carry out a structured physical exercise program in the 6 months preceding this study; who accept to participate in the study, sign the ICF, and present a medical certificate for the practice of physical activity.	Elderly people aged 60 years or older, diabetes mellitus and hypertension uncontrolled, disabling heart disease, cancer, depression, dementia, motor impairment, fall in the last 3 months, and osteoporosis with fragility fracture.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-4zg4nnz	Comparison between Passiflora incarnata Linnaeus and the mixture of Nitrous Oxide and Oxygen in children with anxiety in the dental environment	Recruitment completed	Intervention	2024-05-22	<NULL>	<NULL>	7020	Comparative study between Passiflora incarnata Linnaeus and the mixture of Nitrous Oxide with Oxygen in the control of anxiety in attendance pediatric dentist	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2023-03-15	Faculdade de Odontologia de Piracicaba - Unicamp	Faculdade de Odontologia de Piracicaba - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-4zg4nnz	<NULL>	Children classified according to the American Society of Anesthesiologists (ASA) in ASA I – healthy patient; Both sexes; Child aged between five and twelve years; Accompanied by their parents/guardians, who presents bad behavior, fear and/or anxiety that are resistant to dental treatment, postponing the clinical procedure; Difficulty or behavioral management problems that provide a challenge to the dental surgeon in practice clinic; When basic techniques (voice control, speak-show-do, and protective stabilization) are not permitted or cannot be carried out effectively and safely, due to control of behavior is not enough; No communication difficulties; Children who need simple extraction of deciduous molars, which have at least 2/3 of the root; With periapical radiography of the tooth that will be extracted; Children who accept the mask and collaborate with the technique.	Pre-collaborative children; History of taking medication for pain or anxiety in the 15 days prior to the study; Allergy to drugs, substances or materials used in this experiment; Patients with respiratory tract infections such as the common cold, tonsillitis or nasal obstruction; Mouth breathers due to nasal adenoids; Patient with pneumothorax, cystic fibrosis, infection or recent middle ear surgery and bladder obstruction; Patients who do not accept the mask; Child with chronic obstructive pulmonary disease; Heart disease; Patients with sinusitis or surgeries otolaryngology in the last 14 days; Patients with a strong gag reflex; Patients with disorders muscle tone (cerebral palsy); Presence or suspicion of tumors; Children undergoing chemotherapy use bleomycin or have used it for less than 1 year; Radiotherapy; Osteomyelitis; Psychotic patients; Patients with porphyria; Children whose parents refuse to collaborate with research; Children who do not does not let you touch at all and/or does not sit in the chair; Children who do not accept to participate in the search.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-4hsyy4	Comparison between Pethidine and Dipyrone as Analgesics during Labor	Data analysis completed	Intervention	2018-01-04	<NULL>	<NULL>	1545	Labor Analgesia: Comparison between low doses of Pethidine and Sodium Dipyrone	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-05-28	UNIFOR - Universidade de Fortaleza	Secretaria municipal de saúde de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4hsyy4	<NULL>	Presence of at least 3 uterine contractions lasting 40 seconds or more every 10 minutes; Patients presenting a dilation of the uterine cervix equal to or greater than 5 cm; Measurement of pain through the use of visual analogue scale equal to or greater than 8; Gestational age of 37 up to 40 weeks and 6 days; Fetuses in cephalic presentation	Parturients with any of the following events: poorly controlled arterial hypertension, diabetes, restricted intrauterine growth and placental abruption; Use of oxitocyn by pregnant women in the period from the begining of labor until 2 hours after administration of the analgesic; Hypothyroidism diagnosed previously and without therapy; Patients taking monoamine oxidase inhibitors; Occurrence of labor less than 1 hour after analgesia; Parturients with body mass greater than 100 kg; Indication of cesarean delivery during admission; Addison&apos;s disease previously diagnosed; BCF&apos;s &lt; 110 bpm, during admission; BCF&apos;s &gt; 160 bpm, during admission; Patients allergic to sodium dipyrone; Patients allergic to pethidine; Users of chlorpromazine; Phenobarbital users; Phenytoin users; Fetus without vilality; Twin pregnancy; Drug addiction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-8w9rzy	Comparison between Radioembolization and Transarterial chemoembolization in liver cancer treatment	Recruiting	Intervention	2020-01-07	<NULL>	<NULL>	3337	Comparison between Radioembolization with 131I-Lipiodol and Transarterial chemoembolization in Hepatocellular carcinoma treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-05	Faculdade de Medicina de Botucatu/ Universidade Estadual Paulista	Faculdade de Medicina de Botucatu/ Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8w9rzy	<NULL>	Age of 18 years-old or older; hepatocellular carcinoma graded as intermediate or advanced; liver cirrhosis; performance status of 0 or 1 at the time of the treatment; with contrast-administrated imaging exams before the treatment to assess the treatment response.	Another neoplastic disease; incomplete study procedures; lack of imaging exams during the follow-up; other severe ilnesses in advanced stage that could be more harmful to the patient survival than the hepatocellular carcinoma and the liver cirrhosis, such as chronic obstructive pulmonar disease, cardiac insuficiency, immunosupression (caused by HIV infection or drug-induced) or dialytic kidney insuficiency; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7c7zh75	Comparison between regional techniques and spinal anesthesia associated with general anesthesia for laparoscopic gynecological surgeries - a randomized study	Not yet recruiting	Intervention	2024-12-02	<NULL>	<NULL>	7780	General Anesthesia combined with regional techniques in Laparoscopic Gynecological Surgeries, comparison between Tap Block, Quadratus Lumbar Block and Spinal Anesthesia with Opioid: randomized study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-05-04	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-7c7zh75	<NULL>	Patients aged 18 to 65 years; female; American Society of Anesthesiologists physical status - ASA I or II; undergoing total laparoscopic hysterectomy	Patients with severe comorbidity (American Society of Anesthesiologists physical status - ASA III or higher); cardiac arrhythmias; dilated cardiomyopathy; cardiac conduction disorder; electrolyte disorder; acid-base disorder; hypersensitivity to lidocaine; psychiatric, hepatic, respiratory or oncological diseases; patients who were receiving any type of analgesic in the week prior to surgery; patients who received blood products during the study period; and those whose health insurance does not cover the intervention procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-9f37b4h	Comparison between restorations with Polyethylene Fiber and Cusp Coverage in non-vital posterior teeth: a randomized clinical trial	Recruitment completed	Intervention	2024-02-14	<NULL>	<NULL>	6784	Clinical evaluation of restorations with Polyethylene Fiber as an alternative to Cusp Coverage in non-vital posterior teeth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-15	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9f37b4h	<NULL>	Patients must be at least 18 years old, in good general and oral health; Dental elements of the study should have a premolar or molar with satisfactory endodontic treatment, loss of at least one proximal wall, being in occlusion and having adjacent teeth, have a coronary structure remaining from the buccal or palatal/lingual walls with at least one cavity wall with a thickness of &lt;2mm	Patients with poor oral hygiene will be excluded from the study; smokers; pregnant women; teeth that have color changes due to intrinsic factors (dentinogenesis and amelogenesis imperfecta, fluorosis, tetracycline); periodontal disease; severe parafunctional habits and active clasps of removable partial dentures in the tooth included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-36z72x9	Comparison between Restorations with stainless steel crowns and orthodontic bands: randomized controlled clinical trial	Recruiting	Intervention	2025-03-10	<NULL>	<NULL>	7824	Restorations with stainless steel crowns versus orthodontic bands: randomized controlled clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-29	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-36z72x9	<NULL>	Children aged three to eight years old; of both sexes; treated at the pediatric dentistry clinic of the Federal University of Piauí - UFPI who have deciduous molars with extensive carious lesions on occlusoproximal surfaces, without pulp involvement; the teeth must have sufficient remaining structure for adaptation of a stainless steel crown or orthodontic band	Molars with mobility, pain or symptoms of pulp pathology; gingival inflammation caused by poor oral hygiene	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-5j25nm	Comparison between Rotary and Manual Instrumentation for Root Canal Treatment in Children&apos;s Teeth	Recruitment completed	Intervention	2020-01-29	<NULL>	<NULL>	3424	Comparison between Rotary and Manual Instrumentation in primary molar Biopulpectomies	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5j25nm	<NULL>	"First or second lower deciduous molar with deep caries and pulp vitality that, on radiographic examination, showed pulp involvement;Teeth with painful or spontaneous painful symptoms that did not soften with the use of medication;Teeth with pain or absence of pain, which presented absence of hemostasis in adequate time (up to 5 minutes) after attempted pulpotomy, which macroscopically did not present reversibility characteristics;Absence of fistula or abscess;
Absence of bone thinning on radiographic examination;Absence of internal or external resorption of more than 2/3 of root;Restorative possibility of dental remnant"	Children with difficult behavior who did not cooperate with treatment; Children who have had systemic health problems; Teeth that had periapical lesion or interradicular bone rarefaction;Internal and / or external resorption involving more than 1/3 of the root length;Teeth less than 2/3 of root remnant;Disruption of the pericoronal sac of the permanent successor;Restorative impossibility; Teeth that had some previous pulp treatment;Patients who were taking antibiotics and / or anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-534wr3	Comparison between scraping followed by cauterization and traditional surgery in the treatment of low-risk skin cancer up to 10 millimeters in size	Recruitment completed	Intervention	2020-04-07	<NULL>	<NULL>	3711	Curettage and electrocoagulation VS conventional surgery in the treatment of low-risk basal cell carcinoma up to 10mm in diameter: a randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-534wr3	<NULL>	"Patient at the clinical ambulatory of
Dermatology of the Hospital das Cínicas da FMB-Unesp with diagnosis of low-risk basal cell carcinoma; clinically evident  of up to
10mm in diameter; Sign the informed consent form."	Injury from previous basal cell carcinoma recurrence; Gestation; breastfeeding; Not concordant; Coagulation disorder; Immunosuppression; Difficulty maintaining adequate local care; Difficulty of understanding; Inability to attend outpatient visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-78dh5d	Comparison between skin closure with single and intradermal points on the knee prosthesis	Data analysis completed	Intervention	2020-07-29	<NULL>	<NULL>	4065	Comparative analysis between single and intradermal skin cloruse in total knee arthroplasty	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Hospital Universitario Ciencias Medicas	Hospital Universitario Ciencias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-78dh5d	<NULL>	Patients with primary or secondary gonarthrosis; with indication of total knee arthroplasty; aged 45 to 85 years; both sexes.	Patients with a previous history of knee surgery; with inflammatory diseases of the joints; smokers, i.e. at least 1 cigarette a day; alcoholics with consumption equal to or greater than 15 doses per week for men and 10 doses per week for women; with hypoalbuminemia, i.e. albumin level below 3.5 mg per dl and anemia with hemoglobin less than 10 mg per dl.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-104n8kqh	Comparison between Sodium Fluoride Varnish and Titanium Tetrafluoride Varnish to prevent White Spots in Orthodontics	Data analysis completed	Intervention	2021-07-14	<NULL>	<NULL>	8021	Prevention and Remineralization of White Spot Lesions in Orthodontics: comparison of the efficacy of Sodium Fluoride Varnish and Titanium Tetrafluoride (TiF4) Varnish	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-104n8kqh	<NULL>	Age between 11-18 years; both sexes; complete permanent dentition; having at least one active white spot lesion on the smooth surfaces of the permanent dentition (Nyvad index score 1); being under orthodontic treatment with a fixed appliance initiated between 6-18 months	Patients with cavitated caries lesions; who have undergone topical fluoride application in the past 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-997tqhh	Comparison between Solutions that protect the heart through biopsy and laboratory tests during cardiac surgery.	Recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5170	Comparison between Long term Cardioplegic Solutions in Myocardial protection with Tissue and Laboratory Analysis: Randomized Doubleblind Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Hospital Nossa Senhora da Conceição	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-997tqhh	<NULL>	All patients who underwent valve replacement surgery or myocardial revascularization with cardiopulmonary bypass at Hospital Nossa Senhora da Conceição, Porto Alegre, aged 18 years or over, in accordance with the Free and Informed Consent Form (Annex B), as Resolution 196/6, of June 13, 1988, of the National Health Council	Previous cardiac surgery; Chronic renal failure (serum creatinine greater than 1.5 mg/dL); Serious psychiatric illness; Urgency or emergency; Multiple surgeries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-5fg9c8	Comparison Between Spinal Erector Spinal Muscle Plane Block with Spinal Anesthesia and Morphine Spinal Anesthesia for Reduction of Post Operative Pain in Inguinal Hernia surgeries	Recruitment completed	Intervention	2019-06-06	<NULL>	<NULL>	2756	Comparison Between the Locking Techniques of the Erector Spinal Muscle Plan with Spinal Anesthesia versus Isolated or Opioid Spinal Anesthesia for Analgesia in Inguinal Hernioplasties: a Randomized Clinical Trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-12-04	Universidade do Sul de Santa Catarina	Sianest Servicos Integrados de Anestesiologia	https://ensaiosclinicos.gov.br/rg/RBR-5fg9c8	<NULL>	Patients older than 18 years; of both gender; ASA I and II; who underwent open surgery of unilateral elective inguinal hernioplasty	Patients with other surgery associated with the procedure analyzed (concomitant correction of contralateral or umbilical hernia); patients with ASA greater than III; weight less than 60 or greater than 100 kilograms; history of allergy to any medication of the study; use of anticoagulants or other contraindications to neuraxial block; postoperative cognitive deficit that prevented the patient from understanding / responding to the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-2rhpn6x	Comparison between spinal morphine and nerve block for pain after ankle surgery: clinical study	Recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7238	Evaluation of intrathecal morphine vs. sciatic and saphenous nerve block with or without adjuvants in postoperative analgesia for ankle fracture: a randomized clinical trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2024-07-08	Hospital Getúlio Vargas	Hospital Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-2rhpn6x	<NULL>	Patients of both genders; who agree to participate in the study and sign the Free and Informed Consent Form ICF; aged eighteen years or older and younger than sixty five years; with a physical status classification of one to three according to the American Society of Anesthesiologists ASA; undergoing spinal anesthesia for ankle level surgeries	Refusal to participate in the research; difficulty in understanding the visual analog scale for pain; chronic use of analgesics and or contraindication to the use of nonsteroidal anti inflammatory drugs NSAIDs; body weight less than fifty kilograms to avoid toxic doses of local anesthetics; pregnant women; patients known to be allergic to local anesthetics and analgesics; those with an infection at the needle insertion site; coagulopathy; presence of neuropathy or neurological dysfunction in the lower extremities; and technical difficulties that do not allow for a block considered satisfactory by the technique described in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-5gdwzz	Comparison between sternal closure with sternal plate fixation versus steel wire after transverse sternotomy for bilateral pulmonary transplantation	Recruiting	Intervention	2019-10-15	<NULL>	<NULL>	3089	Comparative study between esternal closure with sternal plate fixation versus steel wire in patients submitted to previous bilateral transverse thoracosternotomy (clamshell incision) for bilateral pulmonary transplantation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-29	Incor (Instituto do Coração)/ FMUSP (Faculdade de Medicina da Universidade de São Paulo)	Incor (Instituto do Coração)/ FMUSP (Faculdade de Medicina da Universidade de São Paulo)	https://ensaiosclinicos.gov.br/rg/RBR-5gdwzz	<NULL>	Above 18 years old; Belonging to the InCor transplant queue; Eligible for sequential bilateral lung transplantation submitted to clamshell incision.	Patients undergoing a new surgical procedure after lung transplantation requiring manipulation of the steel wires or sternal fixation plate other than for osteomyelitis; Intraoperative death; Patients who underwent unilateral lung transplantation or who did not undergo clamshell incision.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-7bk8rf	Comparison between strenght training (muscular strenght) and power training (muscular power) in functional capacity in elderly	Data analysis completed	Intervention	2016-10-19	<NULL>	<NULL>	1047	Functional capacity of pre-frail elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-05	Centro Universitário do Rio Grande do Norte	Centro Universitário do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7bk8rf	<NULL>	age between 60 and 75 years old; female; have not practiced any kind of regular exercise (2 days per week) within 6 months prior to study entry.	with stage 2 hypertension (systolic 160 mmHg and diastolic 100 mmHg); and present musculoskeletal injury that prevented the completion of the training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-249vpp	Comparison between the analgesics ketoprofen and parecoxib for pain control after gallbladder surgical removal	data analysis completed	Intervention	2012-02-13	<NULL>	<NULL>	85	Postoperative analgesia: comparison between ketoprofen and parecoxib in patients submitted to conventional cholecystectomy	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-01-10	Pontifícia Universidade Católica de Campinas - PUCCAMP	Pontifícia Universidade Católica de Campinas - PUCCAMP	https://ensaiosclinicos.gov.br/rg/RBR-249vpp	<NULL>	Physical status ASA 1 or 2 patients, undergoing conventional cholecystectomy, of both genders, aged 18 to 55 years old.	"ASA Physical Status 3, 4 or 5.
Patients using hormonal or nonhormonal anti-inflammatory drugs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-6fcwx9s	Comparison between the direct cut technique above the duodenal papilla and the traditional attempt to access the bile duct	Not yet recruiting	Intervention	2025-10-20	<NULL>	<NULL>	8425	Needle-knife fistulotomy versus conventional cannulation attempt: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-02-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6fcwx9s	<NULL>	Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) for the first time; favorable papillary morphology; infundibular bulging of at least 8 mm, with a minimum distance of 3 mm from the papillary orifice and a minimum length of 5 mm for endoscopic incision; age over 18 years; agreement with the Informed Consent Form	Refusal to sign the Informed Consent Form (ICF); previous endoscopic retrograde cholangiopancreatography (ERCP); coagulopathy; surgical history that alters endoscopic access to the biliary tract (e.g., gastrectomy with Billroth II or Roux-en-Y reconstruction); pancreatic sphincterotomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-4q6dtvw	Comparison between the effect of two analgesics on sedation in surgeries in children who fractured the upper limb	Recruitment completed	Intervention	2021-11-05	<NULL>	<NULL>	5018	Comparasion between Fentanyl and Ketamine in the intra-operative sedation of children submitted to orthopedic procedures in upper limb	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-01-02	Universidade de Fortaleza - Unifor	Universidade de Fortaleza - Unifor	https://ensaiosclinicos.gov.br/rg/RBR-4q6dtvw	<NULL>	Children aged between 24 and 192 months. Both genders. Undergoing a surgical procedure for correction of upper limb fractures. No major comorbidities.	Allergy to some medication used in the study. Chronic use of sedatives or analgesics. Previous neurological or motor deficits. Use of alcohol or drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-8s5v5f	Comparison between the effects of neuromuscular training and video game rehabilitation in the treatment of Parkinson&apos;s disease patients	Recruitment completed	Intervention	2019-10-09	<NULL>	<NULL>	3055	Comparison between the effects of fnp-based training and virtual rehabilitation in the treatment of Parkinson&apos;s disease patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-06	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-8s5v5f	<NULL>	Age between 40 and 80 years; to present PD in the 1 to 3 stage according to the modified Hoehn and Yahr classification; sign the Free and Informed Consent Form and the Authorization of Images and Testimonials.	Present cognitive alterations according to the Mini Mental State Examination, observing the following score: if illiterate: score below 19 points, with 1 to 3 years of schooling: score below 23 points, with 4 to 7 years of schooling : score lower than 24 points, and above 7 years of schooling: score lower than 28 points; have neurodegenerative diseases, excluding PD, and osteomioarticular diseases that prevent physical activity, uncontrolled chronic diseases (hypertension, diabetes mellitus, chronic pain), unstable cardiovascular diseases (acute heart failure, recent myocardial infarction, unstable angina and uncontrolled arrhythmias), in addition to being a user of alcohol and / or other toxic substances, contraindications to exercise according to the criteria of the American College of Sports Medicine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-59k78k	Comparison between the effects of Roux-en-Y gastric bypass (traditional surgery) and mini-gastric bypass (new technique) as treatments of morbid obesity	Recruitment completed	Intervention	2017-12-20	<NULL>	<NULL>	1534	Comparison between the effects of Roux-en-Y gastric bypass and one-anastomosis gastric bypass as treatments of morbid obesity: prospective randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-59k78k	<NULL>	Morbidly obese individuals which are candidates for bariatric surgery according to the National Institutes of Health (NIH) and Brazilian Dept. of Health criteria; any gender; obese for at least 5 years; aged 18-70 years old; Body mass index &gt;= 40 kg/m2; body mass index &gt;= 35 kg/m2 with obesity-related co-morbidities (hypertension, dyslipidemia(s), diabetes mellitus, glucose intolerance, degenerative ostheoarthropathies and/or sleep apnea).	Loss to follow-up before completion of one-year follow-up; vulnerable groups; non-compensated psychiatric disorders; use of alcohol or illicit drugs; misunderstanding of the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-537bzqt	Comparison between the use of Connective Tissue Graft and Platelet Rich Fibrin treated with Ozone in the treatment of Cairo type I Gum Recession: a randomized controlled trial	Terminated	Intervention	2025-08-12	<NULL>	<NULL>	8203	Comparative Analysis Between the Use of Connective Tissue Graft and the Use of Ozonized Platelet-Rich Fibrin for the Treatment of Cairo Type I Gingival Recessions: Randomized Controlled Clinical Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-537bzqt	<NULL>	Patients who present Cairo RT1 gingival recession; the teeth must be healthy, with all sites presenting a probing depth less than or equal to 3 mm; bleeding rate less than or equal to 5%; without gingival inflammation; free of caries; both sexes	Patients with a history of systemic disease; drug use; pregnant or lactating women; presence of pathogenic occlusal interference; carious lesions; previous surgeries at the site of the recession	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-3t597f	Comparison between the use of hand and mechanized files in the treatment of primary molar canal	Recruitment completed	Intervention	2018-05-09	<NULL>	<NULL>	3690	Comparative analysis between hand files and rotary file in the endodontic treatment of primary molars - clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-12	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-3t597f	<NULL>	Literate caregivers; children aged 4 to 10 years; Free and Informed Consent Form signed; Term of Assent signed; children without systemic involvement in the general health; continuous use of medicines; have not taken analgesics in the last 12 hours; mandibular and maxillary primary molars; pulp necrosis; irreversible pulpitis; inter root pathological lesion; radiolucent periapical lesion not involving the germ of the permanent tooth or more than half the length of the roots; up to 2/3 of the radicular root length	Teeth that can not be filled; teeth that can not receive absolute isolation; external pathological reabsorption; calcifications; teeth submitted to previous endodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-3mvj4m7	Comparison between the use of physiotherapy or not during labor of induced pregnant women	Recruiting	Intervention	2021-03-09	<NULL>	<NULL>	4569	Comparison between kinesiotherapy and usual care during the first period of labor of pregnant women induced by misoprostol: A randomized pragmatic clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-05	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3mvj4m7	<NULL>	Pregnant women who are 18 years of age or older; Labor induced by the drug Misoprostol (25mcg, vaginally); Single pregnancy; Pregnant woman generating a live fetus; The pregnant women who will compose the study group must present cervical dilation greater than or equal to 5 cm at the beginning of the intervention	Maternal physical and / or mental disability; Fetal malformation; Women in an expulsive period of labor.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-5nk2tr	Comparison between Therapeutic Back Exercises and Therapeutic Pilates in patients with non-specific Low Back Pain	Recruitment completed	Intervention	2019-12-16	<NULL>	<NULL>	5618	Comparative randomized controlled study between Therapeutic Exercises of the Therapeutic School of the Back and Pilates in patients with non-specific Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-21	Hospital universitario del Henares	Hospital universitario del Henares	https://ensaiosclinicos.gov.br/rg/RBR-5nk2tr	<NULL>	Older than 18 years; Affected with low back pain	Age less than 18 years; Patients not belonging to the Hospital del Henares; Less than 3 months of evolution of the pathology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-39czsv	Comparison between Therapeutic Ultrasound and Anesthesia Injection in women with Tummy Pain caused by a pain point for more than 6 months	Recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2025	Therapeutic Ultrasound and Local Anesthetic Injection in the treatment of women with Chronic Pelvic Pain secondary to Myofascial Abdominal Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-15	Faculdade de Medicina de Ribeirão Preto - FMRP-USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP - HCFMRP	https://ensaiosclinicos.gov.br/rg/RBR-39czsv	<NULL>	Women older than eighteen years and not menopausal with clinical diagnosis of abdominal myofascial syndrome with presence of only one active trigger point and pain above four point four (moderate pain) in the visual analogue scale (VAS) and without previous treatments.	Pregnant women with hip prosthesis, neoplasias in the abdomino-pelvic region, with severe osteoporosis, copper IUDs, abdominal varicose veins, cognitive deficits that make the questionnaires difficult to comprehend, women with anticoagulation or hemorrhagic disorders, local or systemic infections, allergy to anesthetics, acute muscle trauma, extreme fear of needles, history of complaints of chronic musculoskeletal pain such as fibromyalgia, chronic fatigue or diabetes. Also included in the exclusion criteria are those who use chronic painkillers, anti inflammatories, and tricyclic antidepressants who have used aspirin within three days prior to injection, all patients with suspected interstitial cystitis, bowel syndrome irritable or other disease that justifies or contributes to CPP, will also be part of the criteria for exclusion of endometrioma or hernia evidenced by ultrasound of the abdominal wall, abdominal wall infections and women who are missing after the start of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-4yccqm	Comparison between three brands of nasal spray for the treatment of allergic rhinitis	Recruiting	Intervention	2020-07-22	<NULL>	<NULL>	4030	Comparison of three topical budesonide brands in the treatment of allergic rhinitis: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Clinica Olfact	Clinica Olfact	https://ensaiosclinicos.gov.br/rg/RBR-4yccqm	<NULL>	Patients aged between 18 and 55 years who were diagnosed with allergic rhinitis through clinical criteria and positive specific IgE	Patients under the age of 18 and over 55, with rhinitis triggered by other reasons, other than allergic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-5hh9q5	Comparison between tibial nerve stimulation and  vaginal stimulation to treat urinary loss in elderly women	Data analysis completed	Intervention	2019-11-28	<NULL>	<NULL>	3320	Comparison between Transcutaneous Tibial Nerve Eletrical Stimulation and Transvaginal Eletrical Stimulation to treat Urge Urinary Incontinence in elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-02	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5hh9q5	<NULL>	Women; with 60 years old or more; complaining of urgency urinary incontinence; assisted at the Clinic of Urogynecology at Hospital São Lucas da Pucrs.	Patient complaining of stress urinary incontinence exclusively; genital prolapse above the second stage of the POP-Q classification; patients with pacemakers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-658g535	Comparison between Traditional Dressing, V.A.C. Dressing and V.A.C. Dressing with Instillation in complex wounds	Recruitment completed	Intervention	2021-06-07	<NULL>	<NULL>	6545	Comparison Between Traditional Dressing, Negative-Pressure Wound Therapy with Instillation and Conventional Negative-Pressure Wound Therapy in complex wounds: a prospective, randomized, controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-05	Hospital das Clínicas da Faculade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-658g535	<NULL>	Complex traumatic wound in the inferior limb; acute trauma (less than 72 hours); age between 18 and 80 years-old; inicial care at the Emergency Department of Hospital das Clinicas de São Paulo; treatment by the Group of Complex Wounds of Plastic Surgery	Refusal to sign the Informed Consent; failure in collecting intraoperatory cultures; changing of surgical management; uncontrolled systemic disease; patient not likely to survive during the treatment process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-46rtbv	Comparison between training of two virtual games in the thigh muscle and functional performance of the lower limb	Data analysis completed	Intervention	2019-08-27	<NULL>	<NULL>	2901	Comparison between the effects of plyometric training and virtual training on electromyographic activity, kinematics, and functional performance of the trunk and lower limb	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-46rtbv	<NULL>	women aged 18 to 30 years; healthy	Women who had serious health problems; current or previous injuries in the lower limbs; signs of inflammation; pain and joint instability in the knee	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-8sm6kkk	Comparison between treatment with Oral Minoxidil at doses of 1 mg per day and 2 mg per day in the treatment of Female Baldness	Recruitment completed	Intervention	2025-04-04	<NULL>	<NULL>	7890	Oral Minoxidil 1 mg versus Oral Minoxidil 2 mg for treatment of Female Pattern Alopecia: a randomized, double-blind clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-06-01	Clinica Sanabria Transplante e Restauração Capilar	Clinica Sanabria Transplante e Restauração Capilar	https://ensaiosclinicos.gov.br/rg/RBR-8sm6kkk	<NULL>	Females; age between 18 and 60 years; diagnosis of female pattern alopecia classified between grades II and IV on the Sinclair scale	Patients who have undergone previous treatment for hair loss in the last 6 months; patients diagnosed with systemic arterial hypertension, heart disease or kidney disease; patients with other causes of hair loss; presence of dermatoses on the scalp	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-5chx4n6	Comparison between two candidosis treatments in patients undergoing head and neck cancer through photodynamic therapy	Recruiting	Intervention	2021-02-02	<NULL>	<NULL>	4498	Comparison between two photodynamic therapy protocols in the candidosis of patients undergoing treatment for head and neck cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	Univesrsidade Estadual de Montes Claros	Univesrsidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-5chx4n6	<NULL>	Individuals with confirmed histopathological diagnosis; CCECP treated exclusively with radiotherapy; or associated with chemotherapy and  or; surgery at the Oncology Sector of Hospital Dilson de Quadros Godinho.	Exclusion criteria will be patients with histological diagnoses other than CCECP; or who have not agreed to participate in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-4mtyr5	Comparison between two different materials for making aesthetic orthodontic bandages in terms of color stability and elastic properties	Data analysis completed	Intervention	2020-07-21	<NULL>	<NULL>	4025	"Aesthetic orthodontic bandages: evaluation of elastic properties and alteration of
color"	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo (FORP/USP)	Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo (FORP/USP)	https://ensaiosclinicos.gov.br/rg/RBR-4mtyr5	<NULL>	Patients with complete permanent dentition (except third molars); between 12 to 20 years old, undergoing orthodontic treatment; good general and oral health; who have not used mouthwash and systemic medication in the last 3 months.	Patients in the transitory phase of dentition, still with the presence of deciduous teeth, presenting poor oral hygiene and consequent oral health, patients with systemic problems and who have used mouthwash and systemic medication for continuous use in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-38xfyp5	Comparison Between Two Exercise Protocols in the Treatment of Rotator Cuff Tendinopathy: randomized clinical trial	Recruitment completed	Intervention	2024-11-06	<NULL>	<NULL>	7489	Effects of Proprioceptive Neuromuscular Facilitation Exercises in the treatment of Rotator Cuff Tendinopathy: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-02	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-38xfyp5	<NULL>	Participants of both genders; aged between 18 and 65 years; who have had shoulder pain for at least three months, the pain should be localized in the lateral and proximal region of the superior aspect of the shoulder (corresponding dermatome of the C5 nerve root), and this complaint should be aggravated during the execution of at least 3 out of 5 specific tests for rotator cuff tendinopathy, which are: Neer, Hawkins-Kennedy, Painful Arc, Jobe, and lateral rotation against resistance; participants should not have passive limitations in flexion, abduction, and external rotation movements	Patients with any history of previous shoulder joint injury; radicular symptoms from the cervical spine; generalized pain condition; evidence of complete rotator cuff tear with loss of active shoulder mobility; fractures in adjacent joints (elbow, wrist/hand); participants with a clinical diagnosis of diseases such as rheumatoid arthritis, cancer, neurological diseases, cognitive disorders, and psychiatric illnesses; all with a history of alcoholism; smoking; those who are constantly using corticosteroids (injectable/oral) or anticonvulsants; and all who are unable to complete all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-9gh6js	Comparison between two forms of electrical stimulation producing contraction in the force gain of the flexor muscles of the forearm of the non-dominant hand	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1962	Comparison between the Russian current and the Aussie current in the force gain of the flexor muscles of the non-dominant hand	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-20	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-9gh6js	<NULL>	Age range between 18-30 years; female and do not practice regularized physical activities.	History of skeletal muscle dysfunctions prior, acute inflammation in the region to be researched; metallic materials implanted in the arm to be examined; pregnant women; patients with heart disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-2nywjd	Comparison between two Hyaluronic Acid protocols for the treatment of TMJ Arthrosis.	Recruitment completed	Intervention	2020-09-01	<NULL>	<NULL>	4200	Therapeutical efficacy of two clinical protocols for Viscosuplementation of Temporomandibular joint in patients with Osteoarthritis	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Odontologia Universidade Federal do Rio de Janeiro	Faculdade de Odontologia Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2nywjd	<NULL>	It will be included individuals of both genders, literacy, over 18 years, presenting at least one of the following symptoms: unilateral or bilateral TMJ pain, occurring spontaneously and/or during mandibular function; presenting joint noises: crepitation or click, unilateral or bilateral; mouth opening limitation and articular pain during palpation of the TMJ, either unilateral or bilateral. All study subjects must meet the criteria of group III of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC-TMD). Each individual should have a CT scan showing one or more of the following changes: joint erosion, proven by loss of normal cortical bone design; sclerosis of parts or all of the condyle and/or joint eminence; flattening of joint surfaces; presence of osteophyte; presence of subchondral cysts.	Individuals who do not meet the inclusion criteria; history of TMJ surgery; volunteers with impaired verbal communication due to neurological disorder, previous disease sequelae or psychiatric condition; pregnant women; individuals taking osteoarthritis modifying medications such as condoitine, glucosamine or diacerin; illiterate individuals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-67h649	Comparison between two IUD immediate postpartum	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1805	Comparison between copper IUD (intrauterine device) and levonogestrel-releasing system immediate postpartum - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-15	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-67h649	<NULL>	Age between 18 and 43 years; gestational age at delivery greater than or equal to 37 weeks; hemoglobin major than 8.0 during prenatal care; desire to use IUD as contraceptive method; immediate Postpartum of single gestation	Diagnosis or suspicion of ovular infection; diagnosis of any other infection (anywhere); active STD (sexually transmitted disease); uterine malformation (bicorn, septate);uterine myomatosis that deforms the cavity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-49gqnnz	Comparison between two materials to stop enamel caries lesions in permanent teeth - randomized clinical trial	Recruitment completed	Intervention	2024-04-03	<NULL>	<NULL>	6914	Comparison between ART and Silver Diamino Fluoride sealants for enamel caries lesions in permanent molars - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-27	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-49gqnnz	<NULL>	Children whose guardians accept and sign the TCLE (Free and Informed Consent Form); children aged 7 to 13 who allow treatment in schools; both genders; children with erupted first permanent molars or enamel carious lesions (International Caries Detection and Assessment SystemICDAS 1-3)	Children whose parents do not sign the consent form. Children who are absent on the day of treatment. Children who do not cooperate with treatment. Teeth with carious lesions in dentin international Caries Detection and Assessment System ICDAS 4-6. Teeth with enamel defects (amelogenesis imperfecta, hypomineralization molar-incisor, enamel hypoplasia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-59552p	Comparison between two medications in pain control of dental infection: a clinical research in patients	Data analysis completed	Intervention	2019-08-19	<NULL>	<NULL>	2881	Comparison between isolated and associated with Codeine Paracetamol in pain con-trol of Acute Apical Abscess: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-59552p	<NULL>	Patients were included in this research according to the following criteria: individuals 18 to 80 years old; diagnosis of acute apical abscess with pulpar necrosis origin; reporting mod-erate to severe pain at the first appointment (equal or superior to 40mm on VAS).	"They will be relieved to report being allergic to drugs not present, patients with a history of liver disease and infants.
Patients with chronic and / or anti-inflammatory opiates were also excluded, those who were or are users of substances such as crack, oxy, cocaine, marijuana and solvents. In addition, patients with cognitive (and therefore according to scales) as well as patients with cognitive impairment (and therefore from afar)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-49zkm6	Comparison between two methods of caries prevention using two resin-based materials: sealant or infiltrant	Data analysis completed	Intervention	2016-02-17	<NULL>	<NULL>	715	Progression of non-cavitated caries lesions treated with a Resin-Based Selant or a Resin-Based Infiltrant	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-26	Universidade Anhanguera de São Paulo - UNIAN-SP	Universidade Anhanguera de São Paulo - UNIAN-SP	https://ensaiosclinicos.gov.br/rg/RBR-49zkm6	<NULL>	Health volunteers; both genders; aging between 8 and 24 years; molars with intact deep and retentive occlusal fissures to visual inspection; teeth in contact with the antagonist tooth; teeth presenting visual non-cavitated caries lesions located between the enamel and dentin junction and middle one-third of dentin.	Restorations and white spot lesions or cavitations on other tooth surfaces; teeth reported as sensitive to any type of stimulus; physically and mentally challenged volunteers; volunteers with systemic diseases under medication; children with poor oral habits affecting occlusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-8fs5ww	Comparison between two molding techniques in removable partial dentures	data analysis completed	Intervention	2012-11-09	<NULL>	<NULL>	104	A clinical study comparing the technique of forming functional model changed and direct functional impression technique for removable partial dentures free distal end	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-26	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8fs5ww	<NULL>	The Patients must have been rehabilitated in the clinic of the Department of Dentistry degree UFRN be carriers of Removable Prosthodontics Total Upper arch and Removable Partial Denture Lower arch with bilateral posterior free end (Kennedy Class I). The minimum age required to participate in the study will be 18 years and included patients of both genders.	Patients with weakened health care unable to attend; patients with normal classification according to bone height that have less than five or more than eight lower teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-104z966s	Comparison between two Non-Invasive Ventilation methods in children with Acute Respiratory Failure due to Bronchiolitis	Recruiting	Intervention	2023-03-01	<NULL>	<NULL>	5927	Comparison between High Flow Nasal Cannula (HFNC) and CPAP/BiPAP in patients with Acute Respiratory Failure caused by Bronchiolitis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-09	Hospital Municipal Infantil Menino Jesus	Hospital Municipal Infantil Menino Jesus	https://ensaiosclinicos.gov.br/rg/RBR-104z966s	<NULL>	Children under 2 years old; hospitalized for bronchiolitis who evolved with acute respiratory distress and NIV/HFNC requirement	Patients with gestational age less than 35 weeks; bronchopulmonary dysplasia; cyanogenic congenital heart disease or with other alterations with hemodynamic repercussions; liver disease; neuromuscular disease; tracheostomized patients; patients with imminent indication of tracheal intubation; parents that do not agree to sign the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-44zfmv	Comparison between two physical therapy treatments for patients with limited movement of elbow joint and wrist	Data analysis completed	Intervention	2016-02-03	<NULL>	<NULL>	710	Comparative study of the effects of classical kinesiotherapeutic treatment and its effects coupled with Maitland technique in patients with limited movement of elbow and wrist	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-10	Universidade Federal da Paraiba	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-44zfmv	<NULL>	40 male or female volunteers; age between 18 and 70 years; limited range of motion of the wrist or elbow after upper limb fracture healing.	More than one year after the injury; neurological changes in muscle function.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-32j9y23	Comparison between two regional anesthesia techniques to relieve pain after partial breast removal surgery (Quadrantectomy)	Not yet recruiting	Intervention	2025-11-16	<NULL>	<NULL>	8505	Comparison between Pectoral Plane Block (PECS I AND II) and Erector Spinae Plane Block (ESP) for postoperative analgesia in Breast Quadrantectomy: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Female gender; age between 18 and 75 years; unilateral breast quadrantectomy or sectorectomy with or without axillary lymphadenectomy; signed informed consent form; elective surgery	Known allergy or hypersensitivity to local anesthetics such as ropivacaine or related agents; infection at the puncture site; coagulopathy or use of anticoagulants that contraindicate regional anesthesia; previous breast surgery; patient refusal to participate in the study; cognitive or psychiatric disorders that impair understanding of the Visual Analogue Scale; bilateral or radical breast surgery; BMI greater than 40 kg/m²; body weight below 37.5 kg	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:26
RBR-23cg7hc	Comparison between two surgical access techniques for Tibia Fracture treatment	Recruitment completed	Intervention	2025-12-16	<NULL>	<NULL>	8659	Transpatellar vs Lateral Parapatellar approach in the Treatment with Tibial Intramedullary Nails	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-03	Hospital do Trabalhador	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older. Both sexes. Tibial shaft fractures classified as AO/OTA 42. Indication for treatment with locked intramedullary nailing. Ability to comply with follow-up. Signed informed consent form	Open fractures classified as Gustilo-Anderson type IIIB or IIIC. Prior surgery on the affected knee or tibia. Previous or concurrent fasciotomy. Significant associated injuries except ipsilateral fibula fracture. Preexisting degenerative joint disease. Inability to comply with follow-up. Loss to follow-up before 12 weeks	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-5mfhkz	Comparison between two surgical techniques for treatment of the primary pterygium	Recruitment completed	Intervention	2016-02-12	<NULL>	<NULL>	713	Comparison between rotation of conjunctival flap and amnionic membrane transplant in pterygium surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Estadual de Campinas	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5mfhkz	<NULL>	Primary Pterygium. Level II Pterygium. Healthy volunteers. Both genders. Age range 18 to 60 years.	Recidivated pterygium. Level I pterygium. Level III pterygium. Current ocular infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-5s6mnrf	Comparison between two techniques for correction of abdominal hernia in cancer patients	Data analysis completed	Intervention	2021-10-12	<NULL>	<NULL>	4977	Comparison between robot-assisted video laparoscopic Rives-Stoppa techniques in ventral incisional hernia repair in cancer patients: a prospective and randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5s6mnrf	<NULL>	Adult patients (18-65 years) with any abdominal or pelvic incisional hernia following oncologic surgery	Patients that were pregnant, were under systemic chemotherapy, or presented any contraindication to general anesthesia or laparoscopy intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-5cmtnk	Comparison between two techniques of pulmonary re-expansion in patients undergoing laparoscopic bariatric surgery.	Recruitment completed	Intervention	2016-03-01	<NULL>	<NULL>	730	Comparison between application of recruitment maneuver and manual chest compression and decompression in patients undergoing laparoscopic bariatric surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Universidade Estadual de Campinas	Fabiana Della Via	https://ensaiosclinicos.gov.br/rg/RBR-5cmtnk	<NULL>	Patients undergoing gastroplasty by laparoscopic; normal pulmonary function or mild disorders; no osteoarticular lesions (rib fractures or unstable thorax); those who agree to sign the Informed Consent Form.	Hemodynamic instability (Mean arterial pressure &lt;60 mmHg) at the time filed to perform alveolar recruitment maneuver.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-3bgs2m2	Comparison between two Threads for Facial Suspension through the temple	Data analysis completed	Observational	2025-01-21	<NULL>	<NULL>	7671	Comparison between two Suture Threads in Temporal Endoscopic Facial Suspension	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-20	Universidade Palista - UNIP	Universidade Palista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-3bgs2m2	<NULL>	Women. Age 49 to 69 years. Not have performed any aesthetic procedure involving the use of botulinum toxin, injectable fillers of any nature and facial threads and/or sutures in the last 48 months. The result of the FACE-Q Questionnaire - Satisfaction with Facial Appearance should be a final value between 10 and 20 points. Have a medical release form. Absence of systemic, uncontrolled comorbidities. Ability to join the visiting scheme. Commit not to receive any other aesthetic procedure on the face during the study period (18 months)	Indication of rehabilitative dental treatment. Underlying disease or clinical condition that impairs the sequence of study procedures. Have some neuropathic disease. Have bruxism or clenching. Being pregnant. Allergy to any medication used. History of an eating disorder or any other condition and/or disorder related to image or physical appearance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-7fvcjkz	Comparison between two treatments for Burning Mouth	Data analysis completed	Intervention	2022-03-30	<NULL>	<NULL>	6794	Comparative analysis of Burning Mouth Syndrome Treatment using Low Power Laser (LTTP) and Transcutaneous Electrical Nerve Stimulation System: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Departamento de Odontologia - Universidade Federal do Rio grande do Norte	Departamento de Odontologia - Universidade Federal do Rio grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7fvcjkz	<NULL>	Individuals of both sexes, over 18 years of age; subjects who had recurrent intraoral or dysesthetic burning sensation daily for more than 2 hours a day for more than 3 months without clinically evident causal lesions; individuals who presented a sensation of pain, burning or burning in the oral mucosa and who presented some local or systemic factor that justified such symptoms; individuals who were physically and emotionally able to participate in the study tests	Subjects who did not complete the study treatment protocol; individuals who presented clinical alterations in the oral mucosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-354q7d	Comparison between two types of bone graft in post-extraction teeth: non-inferiority clinical trial	Recruitment completed	Intervention	2018-05-22	<NULL>	<NULL>	1836	Comparison between two bone substitutes in post-extraction sites: non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-354q7d	<NULL>	Need of anterior maxillary extraction; systematically healthy patients; signed by the Free and Informed Consent Form	Pregnant or lactating women; carriers of metabolic diseases; use of bisphosphonates.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8q96hsh	Comparison between two types of ergonomic adjustments in cycling	Data analysis completed	Intervention	2021-12-09	<NULL>	<NULL>	5093	Comparison Between 3D Kinematic Bikefitting and Traditional Bicycle Adjustment Recommendations: A Double-Blind Randomized Controlled Trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2020-09-07	Universidade Cidade de Sao Paulo	Universidade Cidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8q96hsh	<NULL>	amateur ciclists	continuous use of painkillers; ride with proposed bike setup	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-92qgnb	Comparison between two types of implants in patients with a history of aggressive periodontitis	Not yet recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1989	Comparison between two implant surfaces in patients with a history of aggressive periodontitis: randomized, controlled clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92qgnb	<NULL>	Older than 21 years; Need for rehabilitation of at least two dental elements with two dental implants, located in the same arch; Systemically healthy, without contraindications to oral surgical procedures; Proper oral hygiene (bleeding on probing less than 20%; plaque index less than 20%); Aggressive Periodontitis already treated; Signature of the free and informed consent form.	Pregnancy or lactation; Existence of metabolic bone disease; Use of drugs that influence bone metabolism; Use of bisphosphonates in the last 4 years; History of malignant tumor, radiotherapy or chemotherapy in the last 5 years; Smokers (greater than 20 cigarettes/day).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-23chpws	Comparison between two types of medications for pain and swelling control after wisdom teeth removal	Data analysis completed	Intervention	2026-02-11	<NULL>	<NULL>	8864	Evaluation of two drug regimens in the levels of PGE2 after surgical extraction of third molars	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Odontologia de Piracicaba – Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18 and 30 years; ASA I (American Society of Anesthesiologists physical status classification I); Presence of mandibular third molars in similar positions; Not using any medication routinely or within the week prior to the study; No known allergy to the drugs used in the study; Surgical site without current signs or symptoms of infection.	Patients with a history of pregnancy or lactation; History of gastrointestinal bleeding or peptic ulcer; Allergy to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs); Patients under continuous use of psychoactive drugs, analgesics, or steroidal and nonsteroidal anti-inflammatory agents; Smokers; Presence of postoperative infection signs or symptoms.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-48z55v	Comparison between two types of peripheral vein catheter	Recruitment completed	Intervention	2017-03-24	<NULL>	<NULL>	1191	Effectiveness of peripheral venous catheter	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-21	Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-48z55v	<NULL>	Age over 18 years; being hospitalized in research units; requires obtaining peripheral intravenous access for intravenous therapy.	Present peripheral venous fragility or any other condition that could impair the puncture with peripheral intravenous catheter; insertion of the catheter in the external jugular vein; have previously participated in the search, regardless of randomization group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-6qycxj	Comparison between two types of Progesterone in endometrial preparation for Transfer of Thawed Embryos	Recruiting	Intervention	2020-03-31	<NULL>	<NULL>	3694	Comparison between Micronized Vaginal Progesterone and Oral Didrogesterone in endometrial preparation for Transfer of Thawed Embryos	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-12-01	Centro de Referência da Saúde da Mulher	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6qycxj	<NULL>	Patients undergoing embryo cryopreservation and thawed embryo transfer due to risk of ovarian hyperstimulation syndrome; excess embryos after pregnancy failure in the fresh transfer; loss of transfer by safe endometrium; who underwent preimplantation genetic testing.	Women with an endometrium smaller than 7 mm after endometrial preparation with estrogen. Patients with a history of recurrent miscarriages; severe male factor; uterine diseases; presence of hydrosalpinx. Patients who had a dominant follicle even with estrogen administration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-2bp5q85	Comparison between two types of skin Flaps for making interdigital web space in the Congenital union of fingers	Recruitment completed	Intervention	2023-03-20	<NULL>	<NULL>	5953	Comparison between dorsal rectangular Flap and hourglass Flap in the creation of commissures in simple Syndactyly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-22	Associação hospitalar de proteção a infância doutor Raul Carneiro	Associação hospitalar de proteção a infância doutor Raul Carneiro	https://ensaiosclinicos.gov.br/rg/RBR-2bp5q85	<NULL>	Children up to 06 years of age; with partial or complete finger union; with or without synostosis between the distal phalanges; authorized signature of the free and informed form	Associated syndromes; complex syndactyly; pseudosyndactyly after trauma; reoperations; first commissure syndactyly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-10g9mjqk	Comparison between two types of surgery to treat Penile Cancer	Recruiting	Intervention	2025-07-04	<NULL>	<NULL>	8098	Comparative study between robotic inguinal lymphadenectomies and pen inguinal lymphadenectomies in patients with Penile Cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-20	Instituto do Câncer do Ceará	Instituto do Câncer do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10g9mjqk	<NULL>	Men with Squamous Cell Carcinoma - SCC of the penis; minimum age 18 years; patients without clinical suspicion of lymph node involvement , but with an intermediate-risk penile tumoror high-risk ; patients with clinical suspicion of lymph node involvement, but with lymph nodes up to 3 cm and not fixed to the skin or deeper structures and without distant metastases	Patients without clinical suspicion of lymph node involvement and with low-risk penile tumor ; patients with clinical suspicion of lymph node involvement, but with lymph nodes larger than 3 cm and/or fixed to the skin or deeper structures and/or distant metastases; patients undergoing neoadjuvant radiotherapy or chemotherapy; dementia, psychiatric or cognitive status that prevents full understanding of the explanations and implications of the research project and treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9v37h9	Comparison between two types of Tooth Anesthesia	Recruiting	Intervention	2017-10-30	<NULL>	<NULL>	1451	Efficacy, Latency, Duration and Anesthetic Depth of the traditional Anesthesia method and an In-System Anesthetic Injection without Comfort-In needle in maxillary molars through the Pulp Tester	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-12	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9v37h9	<NULL>	Patients of both sexes; aged between 18 and 30 years; of any ethnic group; marital status; nationality; naturalness; who require local anesthesia to perform class I restorations in the first right (16) and left (26) first molars; also have second right (17) and left (27) molars; no history of pain or trauma; reactive to the electrical stimulus produced by the pulp tester	Patients under 18 years of age or over 30 years; history of alcohol and drug abuse; patient with some pathology that contraindicates the use of local anesthetics; anemia / pregnancy; use of action drugs in the CNS; use of analgesics and anti-inflammatories; pacemaker carrier; use of appliances and orthodontic bands and have no upper molar	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-7d9dth	Comparison between ventilation with a pressure and with two positive pressure in the nostrils of premature newborns	Data analysis completed	Observational	2015-02-19	<NULL>	<NULL>	394	Comparison of nasal CPAP and nasal CPAP with a Cycling Time in preterm infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-11-17	Universidade de Franca	Santa Casa de Misericórdia de Franca	https://ensaiosclinicos.gov.br/rg/RBR-7d9dth	<NULL>	Infants born at a gestational age of less than 37 weeks and weighing less than 2,500g, who received noninvasive ventilation.	Newborns with congenital malformations, abdominal post-surgery and neonatal infection as well as term newborns	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-5yhhywh	Comparison in open surgery of the use of sutures between the clavicle and the coracoid bone with the use of sutures between the clavicle and the coracoid associated with sutures between the clavicle and the acromion bone in acute acromioclavicular dislocations	Recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8397	Surgical treatment of acute acromioclavicular dislocation: Does acromioclavicular cerclage improve clinical and radiological outcomes of subcoracoid ligature? - Prospective randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital Universitário Professor Alberto Antunes	Santa Casa Misericórdia Maceió	https://ensaiosclinicos.gov.br/rg/RBR-5yhhywh	<NULL>	Patients of both sexes;over 18 years old; diagnosed with acute acromioclavicular dislocation within 21 days of injury; Rockwood type 3;4;5;6	Previous shoulder surgeries; multiple trauma patients; abuse of alcohol or illicit drugs; exposed injuries; carrier of neoplastic disease; associated fractures in the upper limb; adhesive capsulitis; glenohumeral osteoarthritis; psychiatric illness; pregnancy; comorbidities not clinically compensated; presence of active infection, loss of follow up of the first clinical evaluation carried out at 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-3dwp5r	Comparison of  lymphatic drainage and exercises for the arms on changes in lymphatic circulation after surgery for breast cancer	Recruitment completed	Intervention	2015-10-14	<NULL>	<NULL>	632	Comparison of Kinesiotherapy and manual lymphatic drainage in the lymphatic compensation postoperative breast cancer	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-19	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3dwp5r	<NULL>	First surgery for invasive carcinoma of ipsilateral breast; Conducting radical mastectomy.	"Immediate breast reconstruction;  Bilateral surgery; Difference in circumference upper limb prior to surgery more than two centimeters; Motor impairment in the upper limb ipsilateral prior to surgery;  Infection prior ipsilateral upper limb prior to surgery; Realization of sentinel lymph node biopsy;  Radiotherapy prior to surgery;
 Inability to understand the exercises."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-4zzc3p	Comparison of a local anesthetic technique applied by syringe or by computer	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1843	Comparative study of length and duration of Inferior Alveolar Nerve Block with Lidocaine 2% + Epinephrine 1: 100.000 applied by conventional technique or computerized system	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-11-08	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4zzc3p	<NULL>	Volunteers aged between 18 and 35 years; who have not undergone blockade anesthesia in the region in the two weeks prior to the study; present 02 lower molars in need of restorative treatment; not having used any medication that could alter the perception of pain in the two weeks prior to the study.	Hypersensitivity to drugs used in the study - 2% Lidocaine with epinephrine 1: 100,000; Benzocaine 20%; presence of organ dysfunction or clinically significant deviation from normal, assessed during anamnesis; odontophobic; pregnant and / or lactating women; history of drug addiction or alcohol abuse.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-6y3q6c	Comparison of a protocol for the training of pelvic floor muscles isolated and associated with the electrostimulation of posterior tibial nerve for mixed urinary incontinence: a clinical trial randomized and blind	Recruitment completed	Intervention	2019-05-06	<NULL>	<NULL>	2662	Comparison of a protocol for the training of pelvic floor muscles isolated and associated with the electrostimulation of posterior tibial nerve for mixed urinary incontinence: a clinical trial randomized and blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-03	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6y3q6c	<NULL>	To present urinary incontinence, have not performed any previous physiotherapeutic treatment for pelvic dysfunctions, do not have pacemakers or cardiovascular diseases and are not pregnant.	Women presenting with an infectious condition, who present with a grade III or IV prolapse, who complain of unbearable pain at physical examination of pelvic floor muscle strength and who present more than 3 absences during the treatment period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-27kqv5	Comparison of a training videogame with conventional physiotherapy on postural control and quality of life of patients with Parkinson&apos;s disease	Recruiting	Intervention	2016-02-25	<NULL>	<NULL>	718	Effects of physical therapy assisted by Kinect system in postural control, cognition and quality of life of patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-14	Faculdade de Medicina da Universidade de São Paulo.	Faculdade de Medicina da Universidade de São Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-27kqv5	<NULL>	Thirty-two participants will be selected between 50 and 80 years; diagnosed with idiopathic Parkinson&apos;s disease performed by specialized neurologists in extrapyramidal diseases according to the criterion of the Brains Bank of the UK Parkinson&apos;s Society; stages I to III of the Hoehn and Yahr scale; treated with levodopa and/or their synergists; do not present other neurological or orthopedic diseases diagnosed; do not present signs of dementia assessed using the Mini Mental State Examination with cutoff score according to educational level; with visual acuity and auditory normal or corrected; no prior experience with the Kinect system; have not participated in a rehabilitation program in the last two months and sign the Term of Consent of the study.	Patients will be excluded that during the period of the study present any clinical change that makes it impossible to perform physical exercises in standing position as cardiorespiratory; orthopedic or neurological disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-6gzd5dt	Comparison of Acetabular Component positioning between two surgical approaches in total hip arthroplasty	Recruiting	Intervention	2026-03-06	<NULL>	<NULL>	8951	Positioning of the Acetabular Component in Total Hip Arthroplasty performed through the Conventional Posterior Access x Modified Posterior Acces (SPAIRE): prospective randomized comparative study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-05	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients on the primary hip replacement waiting list who have hip osteoarthritis. Patients who are able to read and understand the Informed Consent Form. Age 18 or older. Both sexes	Patients with neurological or orthopedic diseases that alter the gait pattern and may influence functional tests. Need for additional procedures beyond hip prosthesis (shortening osteotomies, need for structured or impacted bone graft, and ankylosed hips or those requiring in situ osteotomy)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-528pyq	Comparison of active videogames And running practices on Endothelial, Inflammatory, Cardiovascular And Metabolic Parameters in Type 1 Diabetes people	Data analysis completed	Intervention	2018-08-13	<NULL>	<NULL>	2117	Active video vames: A coadjuvant in the treatment of Diabetes Mellitus types 1 and 2?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-528pyq	<NULL>	Were included male and female subjects Patients who regularly use insulin and do not use anceolytics; anti-inflammatories; antibiotics and or beta-blockers; do not have an osteo-articular; muscular restriction; peripheral neuropathy or any involvement or complication caused by diabetes that prevents the sessions.	All DM1 were excluded who initiate the practice of other physical exercises during the period of study will be excluded, obtain any type of complication that may be aggravated by VGA practice or by medical report, requesting the absence exit of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-3vhw2hx	Comparison of an Online and Face-to-face Motor Program for infants with Delayed Motor Development	Recruiting	Intervention	2023-03-07	<NULL>	<NULL>	5946	Online and Face-to-Face Program to Improve Motor Development in infants with Delay in Motor Development due to Neurological Injury: a non-randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Universidade Federal de Santa Catarina	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3vhw2hx	<NULL>	Infants at risk for delayed neuromotor development; aged between three and 18 months of corrected age; infants with a risk factor for delayed neuromotor development; including deficits in neurological function according to standardized scales (the General Movements Assessment and a neurological assessment using some items of the Hammersmith Infant Neurological Examination); brain lesions determined by neuroimaging when possible; and delayed motor development (percentile below 25) assessed by the Alberta Infant Motor Scale (AIMS)	Severe genetic abnormalities; hospitalized infants; presence of blindness or deafness; changes in the skin; clinical diagnosis of respiratory diseases; presence of congenital diseases; such as heart disease, renal or ophthalmological alterations; physiologically unstable infants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-3bthn5	Comparison of Analgesia between regional Anesthesia techniques in pulmonary surgeries: Erector Spinae Plane Block versus Paravertebral Block	Terminated	Intervention	2019-08-13	<NULL>	<NULL>	5637	Comparison of Analgesia of Erector Spinae Plane Block in pulmonary surgeries in relation to Paravertebral Block: a randomized multicenter study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-23	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3bthn5	<NULL>	Patients over 18 years of age undergoing unilateral pulmonary surgery under thoracotomy or thoracoscopy approach	Patients who refuse participation. Severe puncture site infection or deformity. Coagulation disorder (International normalized ratio greater than 1.4 or use of anticoagulant medications and platelet count less than 100,000 / mm3). Body mass index greater than 35kg / m2. Renal impairment (creatinine clearance less than 30 ml / min). Failure to operate the Patient Controlled Analgesia system (PCA) or to sign the informed consent form. Patients undergoing bilateral surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-3p7577	Comparison of Anti Pneumococcal Vaccinal Response in HIV-positive Adults	data analysis completed	Intervention	2013-03-13	<NULL>	<NULL>	174	Comparison of Response to Vaccination with Three Different Schemes Pneumococcal Vaccine in Adults Infected by Human Immunodeficiency Virus	<NULL>	1, single-arm-study, double-blind	1	<NULL>	<NULL>	<NULL>	2011-01-01	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-3p7577	<NULL>	All individuals aged 18-60 years with HIV infection documented by enzyme-linked immunosorbent assay (ELISA) and Western-Blot testing, and with T-CD4 count above 200 cells/mm3 in two different occasions in the past six months were eligible. Were included in trial individuals who demonstrated understanding and signed consent form.	Exclusion criteria included: any acute febrile illness at the moment of vaccination, active AIDS-defining clinical condition, previous immunization with any of the pneumococcal vaccines, any systemic malignancy neoplasm, use of immunoglobulin within the last three months, current pregnancy, antecedent of allergy to any of the pneumococcal vaccine components.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-5mch8vb	Comparison of aquatic exercise protocols to improve gait in children with Cerebral Palsy	Recruiting	Intervention	2023-04-18	<NULL>	<NULL>	6016	Comparison of intervention protocols in the liquid environment and its impact on the gait of children with Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Hospital e Centro de Reabilitação da Associação de Assistência à Criança Deficiente	Hospital e Centro de Reabilitação da Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5mch8vb	<NULL>	Children aged between six years and eight years and eleven months with spastic Cerebral Palsy; classified as two or three in the gross motor function classification system	Lack of collaboration, inability to understand commands in the evaluation; children submitted to orthopedic surgeries in the last twelve months; children submitted to peripheral blocks in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-69px3cj	Comparison of arterial blood pressure drop after fast and slow infusion of propofol during general anesthesia	Recruiting	Intervention	2022-06-23	<NULL>	<NULL>	5440	Comparison of the incidence of arterial hypotension between propofol in target controlled infusion and bolus injection during induction of general anesthesia in young adults and non-cardiac surgeries - Randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade de Brasília	Faculdade de Medicina da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-69px3cj	<NULL>	35 to 55 year-old patients; elective surgery under general anesthesia; orotracheal intubation using direct laringoscopy; physical status I or II according to American Society of Anesthesiology classification	Data loss; infusion of drugs or doses out of the protocol; painful stimulus during protocol; refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-4h25ytk	Comparison of balanced solutions in abdominal oncological surgery: a pragmatic, randomized, controlled, double-blind study between Plasmafundin and Ringer&apos;s Lactate	Recruitment completed	Intervention	2024-06-14	<NULL>	<NULL>	7069	Assessment of the impact of two perioperative volume replacement solutions in oncological abdominal surgery on the occurrence of metabolic acidosis: comparison between Plasmafunfin and Ringer Lactate	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-06-01	Fundação Faculdade de Medicina	Instituto do Câncer do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4h25ytk	<NULL>	Major elective oncological abdominal surgeries, expected to last more than 4 hours and requiring a post-operative ICU; age 18 or over; understanding and signing the consent form by the patient or guardian; both genders	Urgent or emergency surgery; severe sepsis or septic shock; patients under 18 years of age; chronic obstructive pulmonary disease; decompensated diabetes mellitus; Body Mass Index (BMI) above 35 kg/m2; left ventricular ejection fraction less than 35%; chronic renal failure on dialysis; participation in another interventional study that has an influence on the intervention of this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-4dmnrr	Comparison of Bio Adhesive and Sutures in the Healing of the Palate after Graft Removal: randomized clinical trial	Not yet recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4203	Comparison of Bio-Adhesive based on Cyanoacrylate and Conventional Sutures in Healing the Palate after Removing the Soft Tissue Graft: Randomized Clinical Trial	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2020-10-15	Centro de Ciências da Saúde (CCS)	Centro de Estudo e Pesquisa em implantes dentários (CEPID)	https://ensaiosclinicos.gov.br/rg/RBR-4dmnrr	<NULL>	"At least 18 years old- 70 years old;
Able to read and understand informed consent document;
Patients needing soft tissue graft with teeth that have miller class I or II recession, more equal 2mm, on the facial aspects;
Presence of periodontally healthy teeth at the recipient site equal or less than 25 percent plaque index;
Ability of the participants to maintain good oral hygiene;
Patient not pregnant or breastfeeding;
Not taking medications known to cause gingival enlargement;"	"Smokers/tobacco users;
Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing;
Patients that have severe gingival recession (Miller class III and IV) or less than 2 mm;
Presence of periodontal disease at the recipient site;
Poor oral hygiene;
Patient pregnant or breastfeeding;
Taking medications known to cause gingival enlargement."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-5t582g	Comparison of Body warming devices and clinical outcomes after Heart Surgery: randomized Clinical Trial	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1995	Comparison of Cutaneous Warming Devices and clinical outcomes in the postoperative period in Cardiac Surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-5t582g	<NULL>	Age 18 years or older; submitted to elective coronary artery bypass grafting with Cardiopulmonary bypass;  Intensive Care unit admission temperature below 36 ° C and greater than 32 ° C.	Other surgical corrections associated with coronary artery bypass grafting with Cardiopulmonary bypass; use of circulatory support devices, intra-aortic Balloon Counterpulsation; extracorporeal membrane oxygenation ; ventricular percutaneous circulatory assistance previus cardiac surgery; patients with chronic renal disease; intraoperative cardiac arrest, immunosuppressed patients; acquired or hereditary coagulation disorders; liver disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-83j396	Comparison of brain connections post open-surgery or carotid angioplasty through functional Magnetic Resonance Imaging	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1796	Brain connections analysis post Endarterectomy versus Stent carotid Angioplasty by functional Magnetic Resonance in rest state	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-23	Instituto de Neurologia e Neurocirurgia de Passo Fundo	União Brasileira de Educação e Assistencia	https://ensaiosclinicos.gov.br/rg/RBR-83j396	<NULL>	Patients 18 years old or older; with carotid stenosis above 60% asymptomatic; or patients who had a transient ischemic attack (TIA) with carotid stenosis above 50%; or ulcerated plaque;  who agree to participate in the study	Patients with severe neurological disease such as parkinsonism, dementia, epilepsy, defined cerebrovascular disease, encephalopathy, severe depression; Patients who use drugs that directly affect the central nervous system, which prevent individualized natural responses to the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-86dcdx	Comparison of Bronchoalveolar Lavage and Tracheal Aspirate in the diagnosis and therapy of ICU patients with Ventilator-Associated Pneumonia	Recruitment completed	Intervention	2014-11-25	<NULL>	<NULL>	352	Comparative study of Bronchoalveolar Lavage and Tracheal Aspirate in the diagnosis and treatment of Ventilator-Associated Pneumonia	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2010-08-12	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-86dcdx	<NULL>	"The patients under mechanical ventilation for at least 48 h who presented with new or progressive pulmonary infiltrates on X-rays plus at least two criteria among fever &gt; 38°C, purulent tracheal secretions, and leukocytos greater than 10,000 cells/mm3 or leukopenia of 4,000 cells/mm3, were screened for enrollment.These patients were randomized to undergo BAL (BAL group - 1) or EA (EA group - 2).
Both BAL fluid (BALF) and EA samples were quantitaively cultured. The patients whose cultures were positive with more than 10.000 CFU/mL in BALF cultures and with more than 100.000 CFU/mL in quantitatively endotracheal aspirate cultures (QEACs)— were included in the
study."	"The exclusion criteria were a diagnosis of AIDS and inappropriate
respiratory samples (&gt; 10 squamous cells in the lower field magnification in EA
smears or &gt; 1% bronchial cells in BALF smears). cases with BAL fluid with more than 1% of bronchial cells."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-58bry9	Comparison of Calcium Use in Patients with Lack of Parathyroid Hormone, Taken in Three Different Ways: Fasting, with Water or Orange Juice, and After Breakfast	Recruitment completed	Intervention	2015-03-09	<NULL>	<NULL>	416	Comparison of the Absorption of Calcium Carbonate in Patients with Definitive Hypoparathyroidism Ingested Three Different Ways: Fasting, with Water or Orange Juice, and After Breakfast	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Faculdade de Medicina de Botucatu - Unesp	"Faculdade de Medicina de Botucatu - Universidade Estadual Paulista ""Júlio de Mesquita Filho"" - Unesp"	https://ensaiosclinicos.gov.br/rg/RBR-58bry9	<NULL>	Female, regularly followed at the outpatient thyroid neoplasms; carriers after definitive surgical hypoparathyroidism, with persistent symptoms after at least 1 year after completion of total thyroidectomy due to CDT; between 18 and 50 years of age, who had no serious illnesses and who agreed and signed the Informed Consent.	Menopause; neuromotor disorder; sequela of stroke; malabsorptive syndrome; digestive complications of the gastrointestinal tract; decompensated diabetes; severe hypertension; chronic renal failure; liver disease; malnutrition; cancer; manifest hyperthyroidism; severe chronic obstructive pulmonary disease; patients with therapy antirreabsortiva bone, or use of corticosteroids, thiazides, omeprazole and prokinetics; hat are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-10kynbky	Comparison of caloric expenditure in two types of high-intensity exercise in middle-aged individuals	Not yet recruiting	Intervention	2023-04-19	<NULL>	<NULL>	6025	Comparison of post-exercise energy expenditure and Excessive Oxygen Consumption (EPOC) in response to high-intensity interval exercise performed in a single session versus three shorter sessions over the course of a day in middle-aged subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-05	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-10kynbky	<NULL>	Healthy individuals aged 45 to 64 years; physically active.	Individuals diagnosed with cardiometabolic, renal, and pulmonary diseases; Individuals with orthopedic or neurological limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-48342g	Comparison of catheters placed in the vein regarding the formation of blood clots	Recruiting	Intervention	2019-04-18	<NULL>	<NULL>	2613	Peripheral insertion central catheter with Bioflo® technology versus Power Picc®: incidence and predictors of thrombosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Hospital Israelita Albert Einstein	Faculdade Israelita de Ciências da Saúde Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-48342g	<NULL>	Hospitalized patients with intravenous therapy scheduled for 6 days or longer with a medical order for PICC insertion	"Patients classified as urgency, because it prevented randomization;
Patients who required a specific catheter for continuity of treatment;
Patients who required a new PICC after being recruited for the study;
Patients with a previous diagnosis of DVT;
Patients previosuly mastectomized on the side chosen for insertion of the catheter;
Patients with damaged/sclerosed peripheral venous network;
Patients with bacteremia;
Patients with dermatitis/cellulitis or trauma to the arm to be punctured."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-8cbp4xh	Comparison of cellular response in dental procedures using synthetic bone grafts compared with bovine grafts in dentistry	Recruiting	Intervention	2021-05-07	<NULL>	<NULL>	4627	Histomorphometric and immunohistochemical comparison of bone substitutes in lifting of maxillary sinuses and filling fresh alveoli using Nanosynt and Bio-Oss	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal do Mato Grosso do Sul	DentsCare Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-8cbp4xh	<NULL>	Healthy patients; Be over 18 years old; Enjoy good systemic health; Enjoy good oral health; Have at least 2 teeth that require extraction; Need for surgery to lift bilateral sinus; Anterior teeth that require extraction and that have large alveoli to facilitate the collection of bone tissue without compromising the installation of the dental implant that will be performed concurrently; Posterior teeth that require extraction will only be used if the upper posterior teeth have a broad palatal root socket that will facilitate the collection of bone tissue without compromising the installation of the dental implant performed concurrently with obtaining the material; the lower posterior teeth have a wide distal root socket that will facilitate the collection of bone tissue without compromising the installation of the dental implant carried out concurrently to obtain the material; Maxillary sinuses free from infectious processes and / or pathologies that will harm the research result; Maxillary sinuses without major resorption and that anatomically allow the grafting of biomaterials	Volunteers under 18 years old; with poor oral hygiene; Sinus pathologies; Have teeth with acute infection and suppuration at the site to be filled with biomaterial; Teeth with large septa that will influence sample collection, altering histomorphological and immunohistochemical data due to the presence of native bone; Maxillary sinuses with inflammatory, infectious or tumor pathologies; Maxillary sinuses with great bone resorption that hinder the nutrition of the grafted biomaterials; Present a picture of any other oral infection; Have undergone radiotherapy of the head and neck; Be a user of bisphosphonates; Present decompensated diabetes mellitus; Pregnant woman; Present a smoking habit with a potential capacity to compromise dental implantation (greater than 10 cigarettes per day); Being of indigenous ethnicity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-49pk78	Comparison of Cicatrization Using Topic Light Emitted Diode in Patients Underwent to Abdominoplasty	Recruiting	Intervention	2016-05-17	<NULL>	<NULL>	852	Comparison Between the Application and No Application of Led (light emitted diode) in Cicatrization of Patient Underwent to Abdominoplasty	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-25	Pontifícia Universidade Católica do Rio Grande do Sul	INSERM U1051 Institut des Neurosciences de Montpellier	https://ensaiosclinicos.gov.br/rg/RBR-49pk78	<NULL>	Patients with informed consent signed; caucasian; patients underwent abdominoplasty; patients in whose immediate postoperative period does not show signs of distress or mechanical trauma of the sutured tissue; BMI between 20-30 kg/m2	Patient with indication of multifunctional abdominoplasty or previously undergone to bariatric surgery; patients previously undergoing abdominal surgery that could compromise the vitality of the abdominal flap (cholecystectomy laparotomy for weapon or firearm trauma); patients with autoimmune disorders of collagen metabolism; smoking; diabetes mellitus; chronic hypertension; alcoholism; bleeding disorder; protein malnutrition; immunodeficiency; patients suffering acute or chronic dermatitis or using pharmacological treatment with corticosteroids or chemotherapy; patients undergoing radiation therapy for any reason in the abdominal-pelvic region; patients with known healing disorders (hypertrophic scars or keloids); patients with intestinal bad absorption; patients who have been conducting strict diet prior to surgery; patients who are using another type of product or drug for preventing or improving healing; patient presenting tattoo in the abdominal region and difficult the postoperative evaluation of the scar; patients with medical conditions that interfere with normal wound healing (vitamin C deficiency; iron deficiency; anemia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-8wqqmk8	Comparison of clinical simulation and deliberate practice in rapid cycles for clinical competence development: a randomized clinical trial	Data analysis completed	Intervention	2023-07-28	<NULL>	<NULL>	6281	Evaluation of clinical simulation and deliberate practice in rapid cycles for the development of clinical competence: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8wqqmk8	<NULL>	The student must be enrolled in the fourth year of nursing at the Federal University of São Paulo; have participated in the lecture dialogued in the remote modality on Nursing Assistance to the patient with Cerebral Vascular Accident in the Emergency Service lasting 40 minutes; both genders	Graduates not enrolled in the fourth year of nursing at the Federal University of São Paulo; those who do not participate in the lecture dialogued in the remote modality on Nursing care for patients with stroke in the Emergency Service lasting 40 minutes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-776gwc	Comparison of continuous aerobic exercise effect with interval high intensity exercise in patients with heart failure	Recruiting	Intervention	2016-05-12	<NULL>	<NULL>	1803	Effect of high intensity interval training verses moderate intensity continuos training in functional capacity and quality of life of patients with heart failure: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Federal de Minas Gerais	Hospital Messejana Dr. Carlos Alberto Studard Gomes	https://ensaiosclinicos.gov.br/rg/RBR-776gwc	<NULL>	Individuals with heart failure ; functional classes II and III of the New York Heart Association ( NYHA) ; ejection fraction less than 50%; both genders ; medical clearance ; optimal medical treatment	Subject that presented new cardiac event; clinical decompensation against that indicate the continuity of the physical activity program; and / or to submit physical limitation that prevents participation in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-2t3s88z	Comparison of cost and quality of life in the treatment of varicose veins by normal surgery and by radiofrequency treatment at Hospital de Américo Brasiliense (SUS)	Data analysis completed	Intervention	2025-09-15	<NULL>	<NULL>	8278	Cost-Effectiveness and Quality of Life Study of Safena Magna Treatment by Radiofrequency Ablation and Conventional Surgery at Hospital Estadual de Américo Brasiliense (SUS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-18	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2t3s88z	<NULL>	Symptomatic lower limb varicose veins; age over 18 and under 80; presence of total or partial reflux of the great saphenous vein of one or both or limbs, detected on duplex ultrasound with indication for surgical treatment	Significant underlying diseases in activity such as cancer, lupus, tuberculosis; infectious disease (infected ulcers); history of clotting disorders (thrombophilia); history of thromboembolic events (deep vein thrombosis); use of anticoagulant or antiplatelet medication; pregnancy; high cardiovascular risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9wzwv5	Comparison of Costoclavicular block with Supraclavicular and Axillary block for Upper Limb Surgery: A Randomized Trial	Data analysis completed	Intervention	2019-10-21	<NULL>	<NULL>	4721	Efficacy of surgical analgesia of Costoclavicular block in comparison to Supraclavicular and Axillary blockade, guided by ultrasonography, for procedures distal to the elbow: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Hospital das Clínicas da Universidade Federal de Uberlândia	Hospital das Clínicas da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9wzwv5	<NULL>	Participants undergoing elective and urgent elbow, forearm, wrist and hand surgeries; both genres; aged 18 to 70 years; ASA I to III classification; BMI between 18 and 30	participant&apos;s refusal; classification of physical status ASA greater than III; inability to consent; coagulopathy; sepsis; pregnancy; neuromuscular disease; allergy to local anesthetics; neuropathy or previous deficit of musculocutaneous / radial / ulnar / median; previous surgery in the infraclavicular fossa; infection at the needle insertion site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-2bm36r	Comparison of Cough Assist and Endotracheal Suctioning in airways hygiene of patients in mechanical ventilation	Data analysis completed	Intervention	2015-10-04	<NULL>	<NULL>	626	Comparison of Cough Asisst and Endotracheal Suctioning in bronchial hygiene of patients undergoing mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-17	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-2bm36r	<NULL>	The sample consisted of 43 individuals. Inclusion criteria were patients of both sexes; 18 years; who were on mechanical ventilation for more than 48 hours; with no trauma face and hemodynamically stable.	Were defined as exclusion criteria: history of pulmonary emphysema; presence of barotrauma; thrombocytopenia and impossibility of applying some of the techniques.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-5p27572	Comparison of dental and bone effects associated with Open Bite treatment with Orthodontic Appliance	Recruiting	Intervention	2022-06-23	<NULL>	<NULL>	5439	Dentoskeletal effects of Open Bite treatment with DAVIT (Dual Action Vertical Intra-arch Technique)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5p27572	<NULL>	Anterior open bite clinically greater than or equal to -1 mm; Class I malocclusion; permanent dentition; no need for dental extractions for treatment; absence of craniofacial anomalies; patients without aesthetic complaints of the face or indication for surgical correction of anterior open bite	Patients who do not perform the necessary pre-treatment exams for orthodontic treatment planning; patients who have a contraindication for the insertion of mini-implants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5rcknr	Comparison of different antibiotic vancomycin administration regimens in patients with impaired renal function and need for dialysis	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2693	Comparison of different vancomycin administration regimens in patients with acute kidney injury in hemodialysis therapy: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-5rcknr	<NULL>	septic patients hospitalized in the intensive care sector of Clinics Hospital of Botucatu Medical School -  UNESP; over 18 years old; with AKI and clinical presentation suggestive of acute tubular necrosis (ATN) associated with sepsis; in acute renal support and using vancomycin	pregnant women, patients with AKI of other etiologies; patients who are on chronic renal replacement therapy (dialysis or renal transplantation); patients who have had their dialysis session interrupted for clinical or technical reasons; and patients with serum pre-dialysis seric levels of vancomycin greater than 25 mg/dL	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-9h9c32b	Comparison of different approaches for wisdom tooth extraction	Data analysis completed	Intervention	2021-09-09	<NULL>	<NULL>	4875	Comparison of different approaches - flap designs - in the postoperative of impacted third molar surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9h9c32b	<NULL>	The patient must be aged between 18 and 40 years, have both impacted mandibular third molars with similar positions and angulation, present periodontal health and have the availability of a preoperative panoramic radiograph.	Patients with systemic desabilitation, smokers or using medications that could influence the surgical procedure or postoperative healing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-96cwz48	Comparison of different methods of obtaining of an extubation predictor index in patients subjected to mechanical ventilation	Recruitment completed	Intervention	2021-02-03	<NULL>	<NULL>	4503	Comparison of different methods of obtaining the rapid shallow breathing index in patients subjected to mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	universidade federal do espirito santo	universidade federal do espirito santo	https://ensaiosclinicos.gov.br/rg/RBR-96cwz48	<NULL>	admitted to the Intensive care unit; intubated and on mechanical ventilation for at least twenty four hours; undergoing the spontaneous breathing test; hemodynamically stable; without administration of vasopressors or sedatives; with a arterial oxygen pressure and inspired oxygen fraction ratio above two hundred.	tracheostomized individuals; reintubated in the last seven days; whose family member or guardian refused to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-4njj56p	Comparison of different Selective Laser Trabeculoplasty (SLT) protocols in the treatment of Open Angle Glaucoma and Ocular Hypertension	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8375	Performance of Selective Laser Trabeculoplasty (SLT) protocols - Enhanced and Transscleral - in the treatment of patients with Open Angle Glaucoma and Ocular Hypertension: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4njj56p	<NULL>	Age over 40 yo; Both sexes; Clinical indication for bilateral SLT; Diagnosis of ocular; hypertension or open angle glaucoma (mild to moderate); Open angle on gonioscopy; Baseline intraocular pressure equal to or greater than 16 mmHg	Gonioscopy alterations; Previous intraocular surgery or laser; History of ocular trauma; Advanced OAG; Other types of glaucoma; Associated ophthalmological diseases; Unreliable data; Participants in other clinical trials	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-57t7vb	Comparison of different training methods in diabetic health parameters	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3063	Acute and chronic comparison of different methods of training in kinanthrometric parameters, Cardiovascular, biochemical and metabolic disorders of diabetics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-08	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-57t7vb	<NULL>	Will be included female and male volunteers over 10 years until 90 years and who do not have medical restriction to exercise or any kind of secondary diseases that may be aggravated due to research participation (secondary diseases already diagnosed by the doctor responsible for each diabetic (eg, peripheral and or central vasculopathies, retinopais and amputations).	Those who do not finish the sessions (acute), begin the practice of physical exercises during acute and chronic designs, or suffer any type of osteo-articular injury that prevents the practice of physical exercises or at the request of the doctor responsible for the exercise. each diabetic outside the scope of the research. In the chronic phase, volunteers who do not participate in at least 50% of the sessions will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-10t8dj3b	Comparison of different types of implants in various clinical situations and loading protocols - Ongoing clinical study	Not yet recruiting	Intervention	2025-12-24	<NULL>	<NULL>	8681	Comparative evaluation of different implant designs in various clinical situations and loading protocols. a prospective clinical trial	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Male and female patients; Patients aged between 18 and 75 years; Patients in good general health (physical and mental) at the time of surgery; Patients who provide free and informed consent	Patients who smoke; Patients with a known history of current alcohol, drug, or medication abuse; Patients with systemic non-controlled diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-4j62jv6	Comparison of different ways to insert the Copper IUD in women after vaginal delivery	Not yet recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5044	Comparison of Copper Intrauterine Device Insertion Methods in the immediate postpartum	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Hospital da Mulher Prof. Dr. J. A. Pinotti-Caism/Unicamp	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4j62jv6	<NULL>	Pregnant women between 18 and 43 years old; hemoglobin greater than 8.0 mg/dl during prenatal care; single pregnancy; desire to use IUD as a contraceptive method	Pregnant women with diagnosis or suspicion of ovular membrane infection; diagnosis of any other infection (anywhere); active sexually transmitted infection; uterine malformation (bicornuate, septate uterus); uterine fibroids that deform the cavity; pregnant women with scheduled cesarean	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-2f836zh	Comparison of different weekly volume progressions in Resistance Training on muscle growth and proteolysis markers in trained Individuals	Recruitment completed	Intervention	2024-11-06	<NULL>	<NULL>	7484	Effects of different weekly volume progressions of Resistance Training morphological adaptations of trained young adults: a controlled, randomized, within-subject study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal de São Carlos	Laboratório de Adaptações Neuromusculares ao Treinamento de Força	https://ensaiosclinicos.gov.br/rg/RBR-2f836zh	<NULL>	Women and men; aged between 18 and 35; who have been practicing strength training for the lower limbs for at least 2 years and no more than 5 years; who perform a weekly volume of 12 to 20 sets for the quadriceps muscles (including the 45º leg press and extension chair exercises).	Use of anabolic steroids; chronic use of vitamin supplements and/or anti-inflammatory medications; any musculoskeletal injury of the lower limbs and neuromuscular disorders that could prevent the execution of the protocols proposed by the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-83ckh3	Comparison of drugs for anxiety relief before heart surgery	Data analysis completed	Intervention	2012-02-13	<NULL>	<NULL>	3047	Randomized blind prospective study: a comparison of midazolan, morphine or clonidine as premedication for cardiac surgery	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-08-01	Instituto de Cardiologia do Rio Grande do Sul	Ari Tadeu Lírio dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-83ckh3	<NULL>	Patients undergoing cardiac surgery with cardiopulmonary bypass; age of 18-65 years.	Non-elective surgery; weigh less than 50 or more than 100 kg; history of psychiatric disorder; ASA physics status of class IV; patients with a mental impairment, knowledge about allergy to studied drugs;  patients with congenital cardiac disease and the patients that don&apos;t give informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-4hsfyg	Comparison of effect of bath performed before hip prosthesis surgery with three different solutions	Recruiting	Intervention	2016-05-17	<NULL>	<NULL>	851	Comparison of preoperative bathing effectiveness with three solutions in patients undergoing hip arthroplasty: a clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-18	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-4hsfyg	<NULL>	Patient with an elective procedure of total hip arthroplasty; age of 18 years or more; no report of infection at the surgical site; with access to landline or mobile; know autodiagnosticar informing the clinical signs of the infection or have a responsible with this ability; don&apos;t be Staphylococcus aureus nasal carrier prior to surgery.	Patient treatment of surgical site infection; undergoing hip replacement surgery in urgency situations; emergency; orthopedic trauma; with a history of allergic reactions to the products used in the bath; underwent partial hip arthroplasty surgery; nasal Staphylococcus aureus carriers before surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-785c8h	Comparison of Effectiveness in the Control Of Pain In Surgery Between Articain 4% With Adrenaline 1:100.000 and Lidocaina 2% With Adrenaline 1:100.000 In Inferior Third Molars Extractions: Randomized Clinical Study	Recruitment completed	Intervention	2019-08-27	<NULL>	<NULL>	2903	Comparison of effectiveness in the control of transoperatory pain between articaine 4% with adrenaline 1:100.000 and lidocaina 2% with adrenaline 1:100.000 in inferior third molars extractions: randomized clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-08	Faculdade de Odontologia da Universidade Federal do Ceará campus Sobral	Faculdade de Odontologia da Universidade Federal do Ceará campus Sobral	https://ensaiosclinicos.gov.br/rg/RBR-785c8h	<NULL>	"Pacients with correct indication for third molars removal;both genders; with ages between 18 and 45 years; indication analyzed with imaginological exams ( panoramic or periapical radiographic); without any systemic diseases
without any periodontal disease; simetric mandibular third molars, with similar class and position;With 2/3 of root formation;pacients that agreed with the Consent Term"	Pacients with acute pericoronaritis and supuration; Bone lesions associated with mandibular third molars; Pacients with no agreement to the study; Pacients ASA III, IV,V and VI; Pacients with presence use of drugs that can may be affect the cicatricial process; Pacients with only one mandibular third molar; Pacients with unsimetric mandibular third molars	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-9vmjs4	Comparison of effects occurring in the spine at the end of the Pilates Method session after balloon massage and after performing exercises on the wall	Recruitment completed	Intervention	2017-07-12	<NULL>	<NULL>	1288	Comparison of the immediate effects on the angles of the thoracic and lumbar curvatures produced by mobilization of soft tissues through massage balls and the execution of wall exercises at the end of the Pilates Method session	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-17	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9vmjs4	<NULL>	Healthy women; Age between 25 and 65 years; Pilates practitioners at the Alinhar Clinic in Pelotas or the Pilates Space Clinic in Uruguaiana; Individuals who have attended Pilates sessions for at least three months.	Pain above grade 7 according to the Verbal Numerical Scale; Presence of gibbosity in the Adams test; Pregnant; Skin rashes that prevent the completion of the massage at the end of the Pilates Method session due to pain or sensitivity on the spot.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-9k4bdds	"Comparison of efficacy and safety between two surgical techniques for correcting eyeglasses errors: small-incision lenticule extraction
(SMILE) and femtolaser-assisted in situ keratomileusis (femtoLASIK)"	Recruitment completed	Intervention	2022-08-12	<NULL>	<NULL>	5547	"Comparison of efficacy and safety between small-incision lenticule extraction
(SMILE) and femtolaser-assisted in situ keratomileusis (femtoLASIK) optimized by
wavefront analysis"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-25	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9k4bdds	<NULL>	Inclusion Criteria: Spontaneous participation of the patient in the study; there is no gender preference; age 18 years or older; myopia or compound myopic astigmatism (with spherical equivalent between -1.00D and -8,00D and astigmatism up to 4.00D)	Exclusion Criteria: Diagnosis of any systemic disease such as diabetes, hypertension, rheumatologic conditions and neurological conditions; eye conditions such as dry eye, corneal opacities, central corneal thickness below 480 microns, manifest or suspected corneal ectasia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-6hpbpc3	Comparison of electric currents in pain relief after cesarean section	Recruiting	Intervention	2026-04-27	<NULL>	<NULL>	9144	Efficacy between medium and low frequency Electrotherapeutic Currents in relieving post-cesarean pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-15	Instituto de Saúde e Biotecnologia - Universidade Federal do Amazonas	<NULL>	<NULL>	<NULL>	Women; aged 18 years or older; subjected to elective or urgent cesarean section; hemodynamically stable; with preserved cognition and able to respond to the researchers&apos; questions	Women with a pacemaker; allergy to electrodes; neurological disorders; infection at the therapy application site; postpartum women with any post-cesarean complications such as hemorrhage, infection, or bleeding at the incision; communication difficulties that make it impossible to answer the research questions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-64vys2	Comparison of Exercises for Urinary Incontinence with and without Electrical Stimulation	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1559	Comparison of a Kinesiotherapy Protocol with and without Association of Posterior Tibial Nerve Stimulation for Mixed Urinary Incontinence: A Randomized and Blind Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-64vys2	<NULL>	To present urinary incontinence; Have not performed any previous physiotherapeutic treatment for pelvic dysfunctions; Do not have pacemakers or cardiovascular disease; Do not be pregnant.	volunteers with infectious disease; volunteers with prolapse grade III or IV; complaint of unbearable pain upon physical examination of muscle strength; more than 3 absences during the treatment period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-4sw7h7	Comparison of fat grafting techniques for reconstruction of head deformities after surgical treatment of epilepsy	Not yet recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2196	A comparative randomized clinical trial of different autologous free fat grafting techniques for reconstruction of temporal contour defects after surgical treatment of epilepsy: structural fat grafting versus micro autologous fat transplantation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Faculdade de Ciências Médicas, UNICAMP	Hospital SOBRAPAR	https://ensaiosclinicos.gov.br/rg/RBR-4sw7h7	<NULL>	Patients over 18 years of age; both genders; ASA (American Society of Anesthesiology) 1 or 2; submitted to standardized craniotomy for the treatment of temporal lobe epilepsy for at least 12 months; with temporal contour deformity; integrity of the craniofacial skeleton	Patients undergoing additional cranial surgery; pregnancy; active infection in the temporal region; previous radiotherapy; contraindications for magnetic resonance imaging such as the presence of cardiac pacing, intracranial metal clips and / or severe claustrophobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-7tvbt4v	Comparison of feeding transition time in premature newborns exposed to Speech Therapy.	Not yet recruiting	Intervention	2022-08-11	<NULL>	<NULL>	5544	Comparative analysis of the food transition process of premature newborns after the application of Speech Therapy Intervention Programs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-23	Irmandade da Santa Casa de Misericórdia de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7tvbt4v	<NULL>	Newborns conceived, with a gestational age of 37 weeks according to the corrected gestational age; preterm newborn who have not yet started offering oral feeding	Presence of genetic syndromes congenital malformations of the head and neck or central nervous system; neurological disorders; clinical instability at the beginning and throughout the study based on the analysis of the medical team on respiratory and cardiac instability of the newborn; levels saturation below 90%; respiratory rate above 60 or any other intercurrences that make speech-language intervention impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-7ssrwz	Comparison of gait with dual task of healthy elderly and with Parkinson&apos;s disease	Recruitment completed	Observational	2016-07-01	<NULL>	<NULL>	905	Comparison of gait biomechanical variables with dual task of healthy elderly and individuals with Parkinson&apos;s disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-16	Universidade Estadual Paulista Julio de Mesquita Filho	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-7ssrwz	<NULL>	Having Parkinson&apos;s disease diagnosis; independent walking; no pain; no fracture; no serious injury to soft tissues in the six months previous to the study; no history of cognitive, cardiovascular or respiratory changes untreated; be able to understand verbal instructions.	Present other neurological diseases than Parkinson&apos;s disease; have less than 60 or older than 85 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-3xsnft5	Comparison of healing and pain after surgery to remove a gingival graft from the palate protected by light-cured fluid composite resin and cyanoacrylate-based tissue adhesive	Not yet recruiting	Intervention	2024-05-14	<NULL>	<NULL>	7003	Comparative analysis of healing and posoperative pain in donor sites of free gingival graft protected with flowable resin composite and cyanoacrylate tissue adhesive	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-3xsnft5	<NULL>	To be 18 or over; do not report the presence of systemic diseases; present healthy periodontium and periodontal stability after conventional periodontal therapy; present a plaque and bleeding index on probing &lt; 10% of sites; needing periodontal plastic surgery using a deephelialized free gingival graft (EGL-d) to treat single and multiple gingival recessions (Class I and II of Cairo, 2011) in the mandible or anterior region of the maxilla (canine to canine); no previous history of palatal graft removal	Pregnancy; report use of medication that may have an adverse effect on periodontal tissues; inadequate endodontic treatment; tooth mobility at the surgery site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-9df4q7h	Comparison of Health in Children and Adolescents Performing Traditional Postural Treatment and Video Game	Recruitment completed	Intervention	2021-09-30	<NULL>	<NULL>	4926	Comparison of Health Indicators in Children and Adolescents Performing Traditional Postural Rehabilitation and Virtual Reality	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-12	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9df4q7h	<NULL>	Individuals with postural changes; regulars at the physiotherapy clinic of the unoeste.	Individuals who do not have early diagnosis of spinal deformities (postural changes); cognitive alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-4dc5yc	Comparison of High Fidelity Simulator versus Dramatization: impact on satisfaction, self-confidence and knowledge of nursing students	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2487	High Fidelity Simulator x Dramatization: impact on satisfaction, self-confidence and knowledge of Nursing students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Escola de Enfermagem de Ribeirão Preto - USP	Universidade do Oeste Paulista - UNOESTE	https://ensaiosclinicos.gov.br/rg/RBR-4dc5yc	<NULL>	"Students regularly enrolled in the 3rd and 4th year of the undergraduate nursing course.
Older than 18 years;"	Failure to comply with the study steps.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-45kv2n	Comparison of hydrotherapy anddry land exercise associated with lasertherapy on pain relief, stretching and daily activities in elderly patients with knee osteoarthritis	Recruitment completed	Intervention	2016-03-02	<NULL>	<NULL>	3216	Comparison of physiotherapy aquatic and dry land exercise associated with low level laser therapy in perception of pain, flexibility and life daily activities in elderly with knee osteoarthritis: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-45kv2n	<NULL>	Volunteers knee osteoarthritis; both genders; age between 60 and 80 years.	Volunteers with severe cardiac and respiratory diseases; fibromyalgia; epilepsy; knee replacement or hip; inability to walk independently; otitis; sores on the skin; mycoses; hydrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-835hmdg	Comparison of intervention with conventional exercises and graded exposure for the treatment of shoulder pain	Not yet recruiting	Intervention	2022-07-19	<NULL>	<NULL>	5494	Graded exposure-based approach compared with a strengthening exercises and manual therapy in patients with chronic shoulder pain: a randomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-835hmdg	<NULL>	Individuals with shoulder pain in the proximal anterolateral aspect of the shoulder; aggravated by movement; who present symptoms lasting at least three months and who present a minimum score of 50 points on the disability scale (Shoulder Pain and Disability Index)	Individuals with a history of trauma or surgery in the shoulder; total rupture of the rotator cuff and biceps tendon; practitioners of sports-level physical activity involving the upper limbs; individuals with a history of cancer; neurological; cardiac and systemic disorders (rheumatoid arthritis or fibromyalgia) in order not to compromise the study objectives; reproduction of shoulder pain with radiating pain; numbness or tingling in the upper limb as an indication of primary involvement in the cervical or thoracic region; presence of wrist dysfunctions (eg. carpal tunnel syndrome); have undergone physical therapy treatment for the shoulder or any other musculoskeletal condition in the last six months; individuals who have contraindications for physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-5wk8nvr	Comparison of intraocular lenses with distant and near vision used in Cataract Surgery	Recruitment completed	Intervention	2023-05-15	<NULL>	<NULL>	6078	Comparison of performance of extended depth of focus intraocular lenses	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-25	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5wk8nvr	<NULL>	Patients diagnosed with bilateral cataracts. Absence of other ophthalmological pathologies. Corneal astigmatism of up to 1D. Literate. No age limit. both sexes	Other ocular pathologies. Impossibility of performing the surgery in both eyes. Illiteracy. Astigmatism greater than 1D	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-5x67ry	Comparison of kinematic variables of gait on a treadmill and on the ground of individuals with Parkinson&apos;s Disease	Recruitment completed	Observational	2016-05-31	<NULL>	<NULL>	874	Comparison of kinematic variables of gait on a treadmill and on the ground of individuals with Parkinson&apos;s Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-23	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-5x67ry	<NULL>	Independent walking; not be in pharmacological adaptation phase; no pain, fracture, or serious injury to soft tissues in the 6 months previous to the study; no history of cognitive, respiratory or cardiovascular disorders not controlled; be classified in stages I to III of Hoehn Yahr scale.	Present other neurological diseases than Parkinson&apos;s disease;to present score lower than 24 on the Mini Mental State Examination that will be applied before the collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-9r68r8y	Comparison of laparoscopic versus robot-assisted treatment for achalasia	Not yet recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6765	Comparison of Laparoscopic versus Robot-assisted Cardiomyotomy with Fundoplication for Achalasia treatment: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9r68r8y	<NULL>	Patients with achalasia; patients with indication for surgical treatment (with Eckardt ≥3); age between 18 and 65 years old; male and female sex	Patients who refused to participate in the study; pregnant patients; patients who have any contraindication to general anesthesia or laparoscopic intervention; morbid obesity (BMI&gt;30 kg/m2); patients undergoing previous diaphragmatic hiatus surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-2bzspnz	Comparison of leg muscle size in critically ill patients in the Intensive Care Unit with ultrasound and computed tomography.	Recruiting	Observational	2022-03-08	<NULL>	<NULL>	5264	Comparison of ultrasound with computed tomography to measure skeletal muscle mass in critically ill patients: Prospective study protocol.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-06-01	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto da USP	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-2bzspnz	<NULL>	Patients over 18 years of age, admitted to the Intensive Care Unit, victims of traumatic brain injury will be included. During the acquisition of cranial tomography exams, a quadriceps tomography will be performed to evaluate the thickness of the muscle group and compared with ultrasound. At each control cranial tomography, at the following times: 24-48 hours and 72-168 hours after admission, controls on the thickness of the quadriceps will be performed by means of tomography and ultrasonography, and these measurements will be compared for possible validation of the method.	Patients with extreme BMI (≤ 18.5 kg/m2 or ≥ 40 kg/m2), with fractures, injuries or burns in the region to be studied and patients with neuromuscular diseases, pregnant women, metastatic cancer, in end-of-life care will be excluded. and in state custody.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9dxqbk	Comparison of Leucine-Rich Alpha-2-Glycoprotein-1 (LRG-1) blood Levels Between Patients With and Without Appendicitis	Recruitment completed	Observational	2020-07-02	<NULL>	<NULL>	3972	Diagnosis of Appendicitis by Analysis of Peripheral Blood - Project APPENDIX	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9dxqbk	<NULL>	Recent abdominal pain (less than 30 days) with at least one more of the other criteria; pain in the right iliac region; pain migrating; nausea or vomiting before vomiting; psoas sign; fever; rebound tenderness (Blumberg sign); abdominal rigidity; no previous similar pain; pain to digital rectal examination; anorexia.	Refusal to participate in the study; have already undergone appendectomy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-52hbf7	Comparison of long-term effects of the technique with contraction of the belly muscles and stretching in patients with back pain	Not yet recruiting	Intervention	2016-07-04	<NULL>	<NULL>	909	Comparison of long-term effects of segmental stabilization technique and stretching in patients with low back pain chronic nonspecific	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal do Amapá - Unifap	Universidade Federal do Amapá - Unifap	https://ensaiosclinicos.gov.br/rg/RBR-52hbf7	<NULL>	For the study are included patients aged 18 to 65 years; patients with a diagnosis of non-specific low back pain with at least three months of progression of pain; patients who signed the informed consent and informed	"Patients pregnant women; patients with specific diagnosis that cause low back pain;
orthopedic, rheumatic and neurological problems; nerve root injury; patients with impaired cognition; patients undergoing treatment during the study period; patient who underwent pre-treatment at least 3 months"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-22bjcq6	Comparison of Mat Pilates versus Equipment-based Pilates for treating knee Osteoarthritis	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7743	Comparison between Mat Pilates and Equipment Pilates in the Treatment of Patients with Knee Osteoarthritis: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-20	Departamento de Fisioterapia da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-22bjcq6	<NULL>	Individuals of both sexes. Aged between 50 and 80 years. Presence of chronic-degenerative joint impairment in the knee for more than 12 weeks. Sedentary individuals diagnosed with unilateral or bilateral knee osteoarthritis. Confirmed diagnosis of knee osteoarthritis according to the criteria of the American College of Rheumatology presence of knee pain and at least one of the following criteria age equal to or greater than 50 years, crepitus during knee movements, increased sensitivity to compression, reduced local warmth, bone enlargement, and morning stiffness lasting less than 30 minutes. Grade 2 or higher osteoarthritis according to the Kellgren and Lawrence classification. Presence of pain with a score equal to or greater than 3 on the Numeric Pain Scale. Use of the Physical Activity Readiness Questionnaire to assess the need for medical evaluation before physical activity practice	Asymptomatic knee osteoarthritis. History of previous surgery on the lower limbs. Diagnosis of neurological inflammatory rheumatic infectious or traumatic disorders. Severe visual impairments. Use of prosthetics in the lower limbs. Inability to understand Portuguese. Body Mass Index above 40. Physical therapy treatment performed in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-2ht76k	Comparison of methods for masticatory function evaluation	Not yet recruiting	Intervention	2015-03-18	<NULL>	<NULL>	424	Comparison of methodologies applied to masticatory function evaluation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Odontologia de Piracicaba UNICAMP	Faculdade de Odontologia de Piracicaba UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-2ht76k	<NULL>	Health subjects; both gender; aged from 25 to 70 years; complete natural dentition or total edentulism wearing a conventional complete denture or a implant supported mandibular dentures.	Diagnostic of caries; periodontal disease; facial malformations; severe malocclusion; posterior crossbite; anterior open bite; parafunctional habits; temporomandibular disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-4b45px	Comparison of methods of oral rehydration therapy in children with acute diarrhea.	data analysis completed	Intervention	2012-04-10	<NULL>	<NULL>	145	Comparison of methods of oral rehydration therapy in children with acute diarrhea.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Centro de Pesquisa Fima Lifshitz	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4b45px	<NULL>	"Male children 2-30 months old
 Pre-classified with acute diarrhea and  dehydration."	"Only breastfeeding nutrition
 With severe malnutrition
 With clinical suspicious or documented signs and symptoms of chronic illness or systemic infection
 Not able to understand the nature of study and sign the inform consent"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-109sw26m	Comparison of methods to better analyze Denture-type Oral Prostheses for toothless patients	Recruitment completed	Observational	2022-03-29	<NULL>	<NULL>	5314	Evaluation of Masticatory Capacity, Maximum Bite Force, Salivary Flow, Quality of Life and Nutritional Status of elderly people submitted to different rehabilitations	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-03-03	Grupo de Pesquisa em Prótese Total	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-109sw26m	<NULL>	age between 60 and 80 years old; both genders; class I intermaxillary relationship;  angulation of artificial teeth Biotone Vita - 33º;  low or moderate alveolar bone resorption (Kapur index);  no report of an allergy to the chewing gum properties, almond, and Optocal silicone;  bimaxillary complete dentures users between 1 and 5 years in good condition.	neuromuscular dysfunction; psychological changes; xerostomia; presence of oral pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-6yppv3	Comparison of minimally invasive techniques in the treatment of severe varices	Recruiting	Intervention	2017-04-03	<NULL>	<NULL>	1202	Comparison of efficacy and safety in the treatment of severe chronic venous insufficiency: endovenous radiofrequency ablation versus endovenous laser ablation versus foam sclerotherapy versus elastic compression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-25	Unidade de Pesquisa Clínica-Faculdade de Medicina de Botucatu - Unesp	Unidade de Pesquisa Clínica-Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-6yppv3	<NULL>	The study will include male and female patients 18 years old or older, with no limits on the maximum age,with active venous ulcers (CEAP 6),primary varicose veins documented by ultrasound,and who agreed to the terms of the studyand signed the free, prior, and informed consent (FPIC).	Patients under 18 years of age; with venous anomalies (e.g. angiodysplasia); with history of deep venous thrombosis and post-thrombotic syndrome; in use of anticoagulants; varicose veins classified as CEAP 5 or less; who had previous saphenectomy in the affected limb; without surgical or anesthetic conditions; with ulcers with signs of active infection; pregnant, postpartum or breastfeeding women; patients with history of migraine; history of interatrial or arteriovenous communication; with active cellulitis or erysipelas; abnormal laboratory liver or kidney function (creatinine clearance below 30ml/m); with signs of active skin mycosis; with previously known retinal changes; history of alcohol or drug abuse; signs of arterial insufficiencyclinically present; signs of clinically decompensated comorbidities; who do not agree with the terms of the study or refuse to sign the free and informed consent (FPIC).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-4c3fz2	Comparison of muscle activity of the trunk and legs in Equine therapy and in the gait of people with Down Syndrome, Cerebral Palsy and Intellectual Deficiency	Not yet recruiting	Intervention	2018-11-09	<NULL>	<NULL>	2333	Eletromiography analisys of the trunk and inferior limbs on the hippotherapy in comparision with the independent gait in subjects with Down Syndrome, Chronic not-progressive encephalopathy of childhood and Intellectual disabilities	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-02	Universidade Federal do Triângulo Mineiro	Associação de Pais e Amigos dos Excepcionais de Uberaba - APAE	https://ensaiosclinicos.gov.br/rg/RBR-4c3fz2	<NULL>	Medical referral; be regularly enrolled in APAE / Uberaba-MG; present independent gait; both genders; aged between 5 and 18 years; signature of the term of responsibility for the practice of equine therapy by parents and / or guardian; Free and Informed Consent signed by parents and / or guardians; medical diagnosis according to each group (Cerebral Palsy, Down Syndrome and Intellectual Disability); the Cerebral Palsy group, only the spastic diparetic type individuals will be included.	individuals with uncontrolled seizures; instabilities in the spine; herniated disc; shoulder and / or hip dislocations; scoliosis above 42 degrees; acute phase rheumatic processes; acute heart diseases; hydrocephalus with valve; uncontrollable fear of the animal, associated syndromes and / or behavioral changes; difficulty understanding commands / tasks; do not make frequent use of drugs such as botulinum toxin that interfere in muscle activity specifically of the muscle groups to be evaluated in this study; abandonment and / or 2 consecutive absences.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-7smyv87	Comparison of muscle strength and discomfort during electrical stimulation in healthy individuals, using self-adhesive electrodes and carbon–silicone electrodes.	Data analysis completed	Intervention	2026-03-21	<NULL>	<NULL>	8980	Comparison of peak torque and discomfort during neuromuscular electrical stimulation in healthy individuals using self-adhesive and carbon-silicone electrodes.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-24	Universidade São Francisco - USF	<NULL>	<NULL>	<NULL>	Women; healthy; aged between 18 and 30; with no history of nerve injury and/or musculoskeletal disorders in the limbs to be tested, which could interfere with the results.	Individuals using continuous pain-inhibiting medication; individuals with cardiac pacemakers; women who are pregnant, in the postpartum period, or menstruating; volunteers who, during the familiarization stimulation, cannot tolerate at least one contraction induced at 50% of their maximum voluntary isometric contraction force	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:23
RBR-7gc7jk	Comparison of nasal cavity after Rapid Maxillary Expansion in patients with Transverse Atresia	Recruiting	Intervention	2020-11-03	<NULL>	<NULL>	4359	Comparison of nasal cavity after Rapid Maxillary Expasion Of Surgery Assisted in adult patients with Transverse Maxilla Atresia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-06	UNIFESP	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7gc7jk	<NULL>	Mouth breathing patients; permanent denture; Angle Class I, II or III presenting transverse maxillary atresia with skeletal involvement without previous orthopedic or orthodontic treatment, with indication of Surgical Assisted Rapid Maxillary Expansion	Potential candidates for adenoidectomy or adenotonsillectomy, complete occlusion of the nasal cavity by nasal turbinates, intranasal tumors or polyps; purulent secretions in the middle meatus or the floor of the nose; patients with marked facial asymmetries, patients with syndromes or patients with craniofacial abnormalities such as Pierre Robin, Treacher Collins, among others; presence of dental changes or periodontal problems in the teeth supporting the maxillary expansion device	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-2mbkswx	Comparison of open surgery using sutures with video surgery using metal buttons in the surgical treatment of acute clavicle dislocation	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7810	Comparative analysis of open versus arthroscopic approaches in acute acromioclavicular injuries/dislocations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-20	Santa Casa Misericórdia Maceió	Fundação Educacional Jayme de Altavila - Fejal	https://ensaiosclinicos.gov.br/rg/RBR-2mbkswx	<NULL>	Patients of both sexes;over 18 years old; diagnosed with acute acromioclavicular dislocation within 21 days of injury; Rockwood type 3;4;5;6	Previous shoulder surgeries; multiple trauma patients; abuse of alcohol or illicit drugs; exposed injuries; carrier of neoplastic disease; associated fractures in the upper limb; adhesive capsulitis; glenohumeral osteoarthritis; psychiatric illness; pregnancy; comorbidities not clinically compensated; presence of active infection, loss of follow up of the first clinical evaluation carried out at 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-2k34tmb	Comparison of orthodontic and speech therapy effects between different mandibular expanders devices: Williams and Schwarz	Recruitment completed	Intervention	2024-12-03	<NULL>	<NULL>	7560	Comparison of dentoskeletal effects and orofacial functions between the Williams and Schwarz expanders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-12	Faculdade de Odontologia de Bauru da Universidade de São Paulo (FOB - USP)	Faculdade de Odontologia de Bauru da Universidade de São Paulo (FOB - USP)	https://ensaiosclinicos.gov.br/rg/RBR-2k34tmb	<NULL>	Both sexes; 6 to 11 years; mixed dentition; Class I malocclusion; atresia of the upper and lower dental arch; mild to moderate crowding of the lower dental arch	Patients with a history of previous orthodontic treatment or extraction of permanent teeth; patients with systemic or neurological alterations that difficult orthodontic therapy; presence of craniofacial syndromes or anomalies; loss of deciduous mandibular canines and second molars; presence of tooth agenesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-9h2kdm9	Comparison of pain levels in nasopalatine nerve blocks using two different techniques	Data analysis completed	Intervention	2022-08-15	<NULL>	<NULL>	5550	Comparison of pain levels in nasopalatine nerve blocks using two different techniques	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9h2kdm9	<NULL>	Both genders; age between 18 and 30 years; any ethnicity; any marital status; any nationality; any place of birth; with previous experience of local anesthesia without intercurrences; not having undergone infiltrative anesthesia in the region in the two weeks prior to the study; and not having used any medication capable of altering pain perception in the two weeks prior to the study	Age lower than 18 years or higher than 30 years old; pregnant or lactating women; history of hypersensitivity to the drugs used in the study; alcohol abuse or drug dependence; psychiatric disorders or systemic diseases; being under treatment with CNS-acting drugs; use of drugs capable of altering pain perception in the two weeks preceding the study; and moderate anxiety or higher (over 9), based on Corah&apos;s Dental Anxiety Scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-8hnvm7	Comparison of Phototherapy versus Therapeutic Ultrasound in the Treatment of Shoulder Injury	Not yet recruiting	Intervention	2019-02-11	<NULL>	<NULL>	2476	Comparison of the red and infrared LEDs in relation to therapeutic Ultrasound treatment on chronic Tendinopathy of shoulder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Anhembi Morumbi	Universidade Anhembi Morumbi	https://ensaiosclinicos.gov.br/rg/RBR-8hnvm7	<NULL>	Medical diagnosis characterized as chronic tendinitis of the shoulder, sign the document informed consent, age between 45 and 70 years, and not using anti-inflammatory or analgesic medication at the time of the study	No chronic tendinitis of the shoulder, age out of the studied range, using anti-inflammatory or analgesic drugs, presenting other pathologies associated with tendinitis, presenting neoplasm, patients with photo sensibility, treated with other methods recently	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-472p29	Comparison of physical exercise in elderly	Data analysis completed	Intervention	2015-03-09	<NULL>	<NULL>	417	Comparison of physical exercise in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Universidade Norte do Paraná - UNOPAR	Universidade Norte do Paraná - UNOPAR	https://ensaiosclinicos.gov.br/rg/RBR-472p29	<NULL>	Women&apos;S; between 60 and 70 years; medical statement for physical exercise; sedentary for at least 6 months	Cognitive impairment according to the Mini Mental State Examination; functional limitations in walking; the use of support devices; affirmative response regarding comorbidities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-4b7gmb	Comparison of physical fitness and the morbidly obese oxygen consumption during different cardiopulmonary test protocols on treadmill and stationary bike	Recruiting	Observational	2017-01-06	<NULL>	<NULL>	1134	Comparison of cardiopulmonary and metabolic performance and CLVO2 analysis in obese patients during cardiopulmonary stress tests on treadmill and bicycle: incremental protocol x constant load	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-03-08	Universidade Federal do Rio Grande do Norte	Selma Sousa Bruno	https://ensaiosclinicos.gov.br/rg/RBR-4b7gmb	<NULL>	The study included female subjects (since obesity waiting list is formed for the most part by women and so there is no contamination of data and bias due to low number of male patients) with: Sheet physical therapy preoperative evaluation completed; subjects with obesity class II and III, have BMI&gt; 35 and &lt;60 kg / m2); the age and / or equal to 18 and less than and / or equal to 59 years; Sedentary individuals or assets; no deficit in the locomotor system and / or balance disorders reported or detected on physical examination without changes in heart function (released by cardiologist by certified to perform physical exercise), and acceptance and signing of the informed consent and informed .	The exclusion was determined when the subjects did not properly perform the ventilatory evidence presented spirometric function not preserved by FEV1 / FVC &lt;0.70, present musculoskeletal limitations or pain preventing the holding of the test, submit a confirmed diagnosis of some heart disease and asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-6dwy85	Comparison of physiological responses between different functional tests in obese	Data analysis completed	Observational	2015-06-25	<NULL>	<NULL>	530	Reproducibility of maximum and submaximal exercise tests in obese subjects using a gas analyzer by telemetry system	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-09-01	Universidade Federal do Rio Grande do Norte	Selma Sousa Bruno	https://ensaiosclinicos.gov.br/rg/RBR-6dwy85	<NULL>	Individuals of both sexes, different degrees of obesity; I, II and III, aged between 18 and 60 years, sedentary or active, no deficit in the locomotor system and or changes in the reported balance or detected on physical examination and spirometric function preserved; FVC&gt; 80%	Exclusion was determined when the testing protocol is not finalized within the given deadline, difficulty in understanding and carrying out the tests or when and musculoskeletal limitations or pain prevented the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-4zvpwb	Comparison of Physiotherapeutic treatments for urine leakage	Data analysis completed	Intervention	2017-11-27	<NULL>	<NULL>	1505	Comparison of the Pilates Mat Method with Perineal Exercises in the treatment of Stress Urinary Incontinence and on Pelvic Floor Muscle Function in women between the ages of 40 and 65	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-20	Faculdade de medicina de Marilia	Faculdade de medicina de Marilia	https://ensaiosclinicos.gov.br/rg/RBR-4zvpwb	<NULL>	Multiparous women in the age group of 40 to 65 years; to present stress urinary incontinence; sign the Informed Consent Form	Prior physical therapy treatment for incontinence urinary stress, or any type of structured and planned physical activity during the study period; already had some surgery of the urinary tract; diagnosis of urinary tract infection, cystitis or genital prolapse; being pregnant; women who could not, even with all the researcher&apos;s attempts at awareness, contract the pelvic floor musculature correctly during the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-6b6wnsy	Comparison of physiotherapy: Conventional and using game, in patients with dialysis chronic kidney disease	Recruiting	Intervention	2021-02-05	<NULL>	<NULL>	4514	Comparison between two physical therapy protocols, conventional or with the use of non-immersive virtual reality in patients with chronic dialysis kidney disease: Randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Federal de Alfenas - Unifal/MG	Universidade Federal de Alfenas - Unifal/MG	https://ensaiosclinicos.gov.br/rg/RBR-6b6wnsy	<NULL>	Both sexes, aged 18 years or over, patients from the hemodialysis session of Hospital Santa Casa de Caridade Alfenas Nossa Senhora do Perpétuo Socorro, who undergo hemodialysis session three times a week, using bicipital fistula for access.	Case of hemodynamic instability, pathological fractures, cognitive deficits, including uncoordinated use of devices, uncontrolled Diabetes Mellitus or systemic arterial hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:19
RBR-6wghcx	Comparison of Pilates and Bodybuilding in Physical Fitness and Quality of Life in the Elderly of Brasília-DF	Data analysis completed	Intervention	2020-09-09	<NULL>	<NULL>	4230	Comparative Analysis of the Pilates Method and Resistance Training in Physical Fitness and Quality of Life of Elderly in Brasília-DF	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Centro Universitário Euro Americano	Centro Universitário Euro Americano	https://ensaiosclinicos.gov.br/rg/RBR-6wghcx	<NULL>	Elderly women aged 60 years or more, who had not been exercising regularly for at least 3 months.	Elderly women who practiced physical exercise regularly, who had some orthopedic condition that would disable the practice of the activities and elderly women with uncontrolled chronic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-3wghh4	Comparison of Polishing systems of veneers in anterior teeth	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1828	Effect of the Polishing System on surface roughness of composite resin veneers: randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-16	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3wghh4	<NULL>	"Be at least 18 years old; good general health; do not present periodontal disease;
Coronal darkness and/or extensive and defective restorations covering the buccal face or color and shape alterations that compromise dental esthetics; ; have an anterior tooth with a higid buccal surface for the purpose of comparison of gloss; present opposing and adjacent tooth; patients without systemic disease or allergies to the materials used; absence of parafunctional habits"	Use of removable prostheses with support on the teeth used for the sturdy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-7r6cf9r	Comparison of Polydioxanone and Polyglactin in midline aponeurosis incision closure after video-laparoscopic surgeries	Recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8699	Comparison of midline aponeurosis incision closure with the use of Trocar of 10-12 mm using Polydioxanone and Polyglactin in video-laparoscopic surgeries: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Hospital Professor Edmundo Vasconcelos	<NULL>	<NULL>	<NULL>	Adults (&gt;18 years) undergoing elective or urgent video-laparoscopic cholecystectomy or inguinal hernia repair; BMI &lt; 35 kg/m²; Signed informed consent	Pre-existing/large umbilical hernias; converted surgeries; pregnant women; immunocompromised patients; collagenoses; local infection; contraindication to video-laparoscopy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-7994vz	Comparison of presence of microorganisms and measurement of calcium , phosphorus . magnesium, sodium and potassium fresh samples collected from the patient side, at home and after pasteurization	Data analysis completed	Observational	2016-08-11	<NULL>	<NULL>	954	Comparison of microbiological and physicochemical property of raw human milk collected at the bedside , at home and after pasteurization	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7994vz	<NULL>	Mothers of newborn preterm who agreed to participate. No consent was obtained for the use of samples taken from the milk bank , as the same were donated by mothers to the hospital	"Mothers who agreed to sign the free and informed consent .
mothers who had their children over 37 weeks of gestation were excluded"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-9bdgxh	Comparison of quadriceps and hamstring muscle strength after exercise at 30% of maximal strength with and without peripheral vascular occlusion in the anterior cruciate ligament postoperative period: a randomized controlled trial.	Recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3416	Comparison of quadriceps and hamstring muscle strength after exercise at 30% of maximal strength with and without peripheral vascular occlusion in the anterior cruciate ligament postoperative period: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9bdgxh	<NULL>	Patients will only be included as participants if they agree to participate; sign the free and informed consent form authorizing their participation in the research; postoperative participants will be included in the study; with anterior cruciate ligament reconstruction; aged 18 to 65 years; men or women; diagnosis of anterior cruciate ligament rupture with planned surgery confirmed by medical examination;	No anterior cruciate ligament injury or reconstruction in the involved or uninvolved limb; patients requiring additional surgical procedures after anterior cruciate ligament reconstruction; infections in the operated region; complete dislocation of the knee;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-3tt2zhz	Comparison of recovery after addition of a medication to spinal anesthesia in patients undergoing uterine removal	Not yet recruiting	Intervention	2024-10-09	<NULL>	<NULL>	7415	Quality of recovery after hysterectomy surgery with the use of clonidine in spinal anesthesia	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3tt2zhz	<NULL>	age between 18 and 65 years; woman; underwent abdominal hysterectomy; american society of anesthesiology physical status 1 and 2	illiterate; contraindication to any medication used in the research; refusal to spinal anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-10scfvch	Comparison of Resistance and Combined Training in older adults with Type 2 Diabetes Mellitus	Recruiting	Intervention	2026-02-04	<NULL>	<NULL>	8828	Comparison of Resistance and Combined Training on metabolic profile, physical performance, body composition, and capillary blood glucose behavior in older adults with Type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-15	Universidade São Judas Tadeu	<NULL>	<NULL>	<NULL>	Men; aged between 65 and 79 years; with type 2 Diabetes Mellitus with a stable dose of medication (oral antidiabetics or insulin or a combination of both) for three or more months; glycated hemoglobin between 6 and 10.0%; without musculoskeletal pain, disabling motor disorders, cardiovascular or musculoskeletal conditions that prevented the performance of resistance or combined training; had not participated in any resistance training or combined training practice at least three months before the start of the pre-intervention tests; normal cognitive level, assessed by the Montreal Cognitive Assessment (MoCA), respecting the cut-off levels according to the participant&apos;s education level	Impossibility of carrying out assessments and reassessments; during the training period they had more than three absences; they had any adverse events related to musculoskeletal pain or worsening of symptoms or signs of pre-existing diseases, mainly changes in systemic blood pressure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-662jnyh	Comparison of respiratory and arm muscle strength training on breathing in patients with Parkinsons Disease	Recruitment completed	Intervention	2023-07-31	<NULL>	<NULL>	6290	Comparison between respiratory and upper limb peripheral resistance training on respiratory function in patients with Parkinson&apos;s Disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Instituto de Ciências da Saúde - Universidade Federal da Bahia	Instituto de Ciências da Saúde - Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-662jnyh	<NULL>	Being on regular medication for Parkinson&apos;s Disease; be in “on” period; be aged 50 years or older; present stage 2, 2.5 or 3 according to the modified Hoehn and Yahr Classification.	Present neurodegenerative diseases excluding Parkinson&apos;s disease, dementia, musculoskeletal diseases that make it impossible to practice physical activity; uncontrolled chronic diseases (hypertension, diabetes mellitus, chronic pain); unstable cardiovascular diseases (acute heart failure; recent myocardial infarction; unstable angina and uncontrolled arrhythmias); use of alcohol and other toxic substances; practicing or having practiced a physical exercise program in the last 6 months; or if you participate or have participated in regular resistance training (eg 2-3 times a week) in the previous 12 months; more than 4 absences during the intervention protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-4hyp7w	Comparison of respiratory, hemodynamic and metabolic effects between two surgical techniques for the treatment of excessive sweating	Data analysis completed	Intervention	2020-04-09	<NULL>	<NULL>	3726	Respiratory, hemodynamic and metabolic effects during thoracic sympathectomy comparing the surgical techniques apneic and carbon dioxide insufflation	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de SAão Paulo	Hospital Estadual de Diadema	https://ensaiosclinicos.gov.br/rg/RBR-4hyp7w	<NULL>	"Age between 18 and 40 years.
ASA 1 and 2.
Ability to understand the scales for assessing pain intensity and performing spirometry."	"Previous respiratory diseases (both obstructive and restrictive).
History of upper airway infection in the last 2 months prior to surgery.
Smoking.
Severe heart disease (NYHA class III or IV, acute coronary syndrome or tachyarrhythmias).
Insulin-dependent diabetes mellitus.
Obese morbid.
Use of illicit drugs.
Pregnancy.
Previous lung surgery.
Mechanical ventilation in the last 30 days.
Contraindication for total intravenous anesthesia.
Refusal of the patient to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4pcbcn	Comparison of satisfaction of patients with high pressure in front of the different tools of health education	Recruiting	Intervention	2019-06-06	<NULL>	<NULL>	2720	Comparison of satisfaction of hypertensive patientes in front of the different tools of health education	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-30	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4pcbcn	<NULL>	Clinical diagnosis of Arterial Hypertension; in follow-up there is a minimum of 1 year; capable of effective oral communication without help	Illiterates; hearing deficiency; visual impairment; cognitive alterations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-5378vnx	Comparison of Shoulder Muscle Gain between two ways of performing the Exercise of Lifting the Arms Sideways while Holding Weights: standing and with the trunk inclined on a bench	Recruitment completed	Intervention	2026-01-09	<NULL>	<NULL>	8728	Lateral Shoulder Raise Exercise with Dumbbells and Muscle Hypertrophy in Deltoids: traditional execution vs. variation with inclined trunk on bench	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-13	Centro de Ciências da Saúde - Universidade Federal de Pernambuco	<NULL>	<NULL>	<NULL>	Healthy women; untrained or minimally active; aged between 18 and 35 years; no participation in resistance training within the last 12 months; non-users of anabolic steroids; non-users of substances that may influence the study outcomes such as creatine or beta-alanine; cessation of use at least 1 month prior to study initiation; no consumption of high doses of caffeine before training sessions; availability to train twice per week on previously agreed days; provision of written informed consent	Positive response to one or more items of the Physical Activity Readiness Questionnaire (PAR-Q); presence of pain or significant discomfort during the specific shoulder abduction test performed on the day of protocol application; attendance below 80% of training sessions; occurrence of injuries during the intervention period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-5tfrhv	Comparison of single-dose preoperative Ibuprofen vs. Ibuprofen with Arginine in the control of postoperative pain in canal treatments	Recruitment completed	Intervention	2018-11-08	<NULL>	<NULL>	3966	Preoperative single-dose comparison of Ibuprofen versus Ibuprofen with Arginine in postoperative pain control in Endodontics: Double-blind, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-05	Universidade Estadual de Ponta Grossa	Centro de Ensino Superior dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5tfrhv	<NULL>	Men or women between 20 and 59 years of age in good health; Satisfy ASA I or II medical history according to the American Society of Anesthesiologists; Need for endodontic therapy in uni or multi-root teeth, asymptomatic with necrotic pulp; Volunteers who can provide informed consent.	Men or women under 20 years of age; Pregnant or lactating women; History of allergy or hypersensitivity to ibuprofen, arginine or local anesthetics; Need for antibiotic prophylaxis; Gastrointestinal disorders, esophageal reflux; Active asthma; Decreased hepatic function; Bleeding disorders; Decompensated diabetes mellitus; Ingestion of analgesics and anti-inflammatories in the last 12 hours (as it may exert a therapeutic effect at the time of the study); Intake of alcoholic beverage in the last 24 hours;Individuals classified as class III to V according to the American Society of Anesthesiologists; Individuals unable to provide informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4psxby	Comparison of Techniques for Treatment of Gingival Recessions	Recruiting	Intervention	2020-04-30	<NULL>	<NULL>	3794	Comparison of Root Coverage Techniques	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4psxby	<NULL>	Volunteers with unitary shallow gingival recessions (less than 4mm), unilateral, type 1 (RT1), in upper or lower canines or premolars; with clinically healthy periodontium and no radiographic bone loss; both sexes; aged between 18 to 55 years.	Volunteers using orthodontic appliances; smokers; pregnant or infants; with previous history of mucogingival or periodontal surgery, fixed or removable prosthodontics, dental cavities, pulp pathology or severe malocclusion involving teeth with gingival recession to be chosen for the study; medication users and/or patients with systemic diseases that may interfere with healing or periodontal health.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4m4pxq8	Comparison of tests performed before liver surgery or transplant with the results of the final definitive analysis	Recruitment completed	Intervention	2026-01-14	<NULL>	<NULL>	8752	Analysis of the correlation between data from pre-resection/liver transplant examinations and definitive diagnostic/histopathological findings in liver studies	<NULL>	n/a, non-randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2020-12-05	Hospital de Clínicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Anonymized data from the liver transplant group of the Department of Surgery at the State University of Campinas were obtained through compilation of information from medical records of patients followed in the focal liver lesion outpatient clinic between January 2010 and January 2021, including information from the records of patients who died, with benign and malignant lesions. Patients over 18 years of age. Patients who underwent liver resection/transplant surgery at the University Hospital of the State University of Campinas	Absence of histopathological results for focal lesions in patients. Loss to follow-up of the patient. Patient refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-8556fzp	Comparison of the accuracy of guided and conventional surgery for implant placement	Data analysis completed	Intervention	2022-02-17	<NULL>	<NULL>	5222	Guided and conventional surgery for implant placement: clinical, radiographic, microbiological, imunoenzimatic and patient-centered evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-06	Universidade Paulista	Universidade Santa Úrsula	https://ensaiosclinicos.gov.br/rg/RBR-8556fzp	<NULL>	Total edentulous maxillary patients; minimum bone thickness of 5.5 mm for implant placement; minimum bone height of 9 mm for placement of 6 implants.	Pregnancy; lactation; antibiotic therapy in the last 6 months, long-term use of medications that could alter osseointegration, such as anti-inflammatory drugs, bisphosphates or immunosuppressive drugs; graft needs before or during surgery; history of previous regenerative procedures in the area designated for implant installation;Patients with severe complications associated with type 2 diabetes, cardiovascular disease; peripheral vascular diseases  such as ulcers, gangrene or amputation; neuropathies; nephropathies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-7df547h	Comparison of the accuracy of the virtual result obtained by the Treatment with the Tooth Aligner of the company Invisalign® with the actual result achieved	Recruitment completed	Observational	2022-04-14	<NULL>	<NULL>	5345	Comparison of the accuracy of the result generated by Clincheck® with the actual result in the Invisalign ® through two treatment protocols	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-20	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7df547h	<NULL>	Healthy volunteers; of both genders; aged between 18 and 45 years; patients with poor dental position type Class I; with all permanent teeth in the mouth; without caries; or gum problems; who were treated without tooth extraction; employees; treated exclusively with the orthodontic aligner manufactured by invisaligncom®the G8 protocols; and prior to g8; during the years 2019 to 2022	Volunteers with cognitive disorders; with craniofacial anomalies; syndromes; patients with diabetes; patients with skeletal problems in the maxilla; and mandible; who received restorations in the teeth; during treatment with the orthodontic aligner manufactured by invisalign®	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-48yfcc	Comparison of the Acute Effect of different types of motor and mental stimuli and combined under the mental, autonomic and motor function of the patient with Respiratory Disease a randomized clinical trial	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3666	Comparison of the Acute Effect of different types of physical and cognitive and combined stimuli under the cognitive, autonomic and motor function of the patient with Chronic Obstructive Pulmonary Disease a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-48yfcc	<NULL>	Medical clearance for testing; diagnosis of COPD; being older than 55 years; without exacerbation or infections for less than 4 weeks; without performing physical activity for at least 4 weeks	Dizziness; Chest pain; severe dyspnoea; SBP greater than 220mmHg and DBP greater than 120mmHg; SpO2 less than 90%; Difficulty adapting to virtual reality; Difficulty using the cycle ergometer; interruption of intervention on their own.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-7zyqq8	Comparison of the Acute Effect of different types of motor and mental stimuli and combined under the mental, autonomic and motor function of the patient with Respiratory Disease a randomized clinical trial	Not yet recruiting	Intervention	2020-03-30	<NULL>	<NULL>	3682	Effect of the lower limbs cycle ergometer associated with conventional physiotherapy in preserving the mobility, morphology and muscle strength of neurocritical patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7zyqq8	<NULL>	"diagnosis of acute neurological injury; aged between 18 and 65 years; use of invasive mechanical ventilation (IMV); 
with more than 24 hours of acute brain event or neurosurgery; admitted to the ICU"	diagnosis of Deep Venous Thrombosis (DVT); diagnosis of brain death (BD); no motor response to the stimulus of the electrostimulator; present criteria for interrupting or not performing the cycle ergometer more than 2 consecutive times or more than 5 times during the ICU stay; express request from a patient or family member to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-23h9cy	Comparison of the Acute Effects of Traditional versus Power Training on Metabolic, Cardiovascular and Psychophysiological Responses in Elderly Hypertensive Women	Data analysis completed	Intervention	2018-01-23	<NULL>	<NULL>	1588	"Comparison of the Effects of Eccentric Strength Training and Muscle Power
on Neuromuscular, Functional and Biochemical Variables in Elderly Individuals"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-17	Universidade Federal do Piauí - UFPI	Universidade Católica de Brasília - UCB	https://ensaiosclinicos.gov.br/rg/RBR-23h9cy	<NULL>	hypertensive women; with above 60 years; without experience with RT in the previous six months.	Subjects with physical disabilities; diagnosis of diabetes; CVDs; hypertension (systolic blood pressure [SBP] 180 mm Hg; diastolic blood pressure [DBP] 110 mm Hg); musculoskeletal disease; or who smoked; or abused drugs/alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-3xfyhh	Comparison of the amount of air expelled by elderly women before and after respiratory exercises	Data analysis completed	Intervention	2017-12-06	<NULL>	<NULL>	1510	Comparison of the Expiratory Flow Peak among elderly women before and after respiratory exercises	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-10	Universidade Presidente Antônio Carlos	Universidade Presidente Antônio Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3xfyhh	<NULL>	Elderly cooperatives; with good cognition; conscious; carriers of heart; metabolic; renal and hepatic diseases; obese; and sedentary women; who answered the Cardiovascular Risk Stratified Questionnaire and who agreed to the Free and Informed Consent Form.	Age less than 65 and greater than 85 years; with high cognitive deficit; tracheostomized; smokers; patients with respiratory and neurological diseases; chauffeured; bedridden; with dementia and that they exposed any conditions that prevented them to carry out the proposed exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-8sxw2r	Comparison of the analgesic effect between acupuncture and dipyrone in acute tooth pain	Recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1930	Comparative analgesia between acupuncture and dipyrone in acute tooth pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-23	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-8sxw2r	<NULL>	Adult subjects; ages 18-45; of both sexes who are not using any type of pain medication in the last 12 hours with complaint of acute tooth pain of pulp origin equal to or greater than 4 in VAS; non-allergic to dipyrone.	"Patient under 18 years of age; pregnant women; acute tooth pain of less than 4 VAS intensity; toothache of non-pulp origin;
volunteers who are using some type of pain medication; allergic to dipyrone."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-10v56ctt	Comparison of the anxiolytic effect during dental anesthesia	Recruiting	Intervention	2025-03-20	<NULL>	<NULL>	7852	Comparison of the anxiolytic effect of Valerian officinalis l., Diazepam and Nitrous oxide during Dental anesthesia	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-08-12	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10v56ctt	<NULL>	Volunteers whose ages are between 18 and 40 years old; participants classified as ASA I; who have the upper 2nd molar used as a reference for application of the anesthetic technique	Patients under 18 or over 40 years of age will be excluded from the study; those weighing less than 50 kg or more than 90 kg; those who have never undergone anesthesia; those with a history of contraindications to the use of benzodiazepines or Valerian; and those with claustrophobia or mouth breathing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-6f2fgkn	Comparison of the application of Current Therapy to the unilateral versus bilateral tibial nerve in women with Urine Leakage	Recruiting	Intervention	2023-09-04	<NULL>	<NULL>	6405	Comparison of unilateral versus bilateral tibial nerve Electrical Stimulation in women with Overactive Bladder Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-6f2fgkn	<NULL>	Women aged 18 or over; diagnosed with overactive bladder syndrome or mixed urinary incontinence with predominance of urgency; women who voluntarily accept the informed consent form (ICF); know how to read and write	Neurological problems or suggestive of neurogenic bladder; proven or suspected pregnancy; any previous treatment for overactive bladder syndrome in the last 3 months; women diagnosed with interstitial cystitis; use of medication to treat overactive bladder syndrome (antimuscarinic and beta-adrenergic) in the last 3 months; women with a history of cervical, endometrial or vulvar cancer; previous pelvic radiotherapy or brachytherapy; women with signs and symptoms of Urinary Tract Infection (UTI) or Pelvic Inflammatory Disease at the time of enrollment; women with genital prolapses assessed at the surgical gynecology outpatient clinic and with a Pelvic Organ Prolapse Quantification (POP-Q) classification greater than grade 2; cardiac pacemaker; previous surgeries to treat urinary incontinence; decompensated diabetes mellitus; loss of peripheral sensitivity on physical examination; skin lesions where the electrode will be placed; use of metallic implants in the region of the lumbar spine, foot and ankle; hormone replacement therapy (HT) in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-256qw7j	Comparison of the clinical performance of dental restorations using regular or flowable resins	Recruiting	Intervention	2023-09-12	<NULL>	<NULL>	6425	Comparison of the clinical performance of restorations in posterior teeth using conventional or flowable resin composite	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-256qw7j	<NULL>	Two posterior teeth needing restorations in the same patient (class II); large cavities or deficient restorations with similar dimensions, cavities involving the same number of tooth surfaces; presence of antagonists and opposing teeth making contact, vital pulp; good oral health; aged between 18 and 70 years and both genders	Very deep carious lesions; crowns that are impossible to restore directly; accidental pulp exposure during caries removal; teeth previously submitted to direct pulp capping; teeth with spontaneous or constant pain, indicative of irreversible pulpitis; severe systemic disease; allergy to restorative materials; periodontal disease; bruxism; deleterious parafunctional habits; history of hypersensitivity in the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-825qxqw	Comparison of the durability of steel crowns and orthodontic bands in children with deficiencies in dental caries treatment - a randomized controlled clinical study	Recruitment completed	Intervention	2024-10-30	<NULL>	<NULL>	7465	Comparison of the effectiveness of Hall technique in relation to cementation of Orthodontic bands in the treatment of caries lesions in deciduous teeth of children with disabilities - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Instituto e Centro de Pesquisas São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-825qxqw	<NULL>	Children with cognitive impairment; both sexes; diagnosis of mild to moderate learning deficit; age range from 4 to 10 years; with the presence of extensive caries lesions involving more than one surface of the tooth, presenting an International Caries Detection and Assessment System score of 5 or 6; with the possibility of sending for 12 months; in which the guardians agreed and agreed to the Free and Informed Consent Form; if the patient had more than one tooth with caries lesion involving two or more surfaces, this patient contributed more than one tooth to a sample	Children whose teeth had pulp exposure; who presented spontaneous pain; teeth in the process of advanced rhizolysis presenting mobility; presence of swelling or fistula near the tooth; furcation or cervical lesion; teeth with restorations, sealants or defects in enamel formation were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-5r93wn	Comparison of the effect and toxicity between two options for the treatment of Mucosal Leishmaniasis: Miltefosin and Liposomal Anfotericin B	Not yet recruiting	Intervention	2018-01-15	<NULL>	<NULL>	2719	Efficacy and safety of Miltefosin in comparison with Liposomal Anfotericin B for the treatment of Leishmaniasis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2018-03-01	Centro de Pesquisa Rene Rachou, Fundação Oswaldo Cruz	Hospital Universitário Julio Muller	https://ensaiosclinicos.gov.br/rg/RBR-5r93wn	<NULL>	Both sexes; age greater than 18 years; mucosal impairment; parasitological confirmation of Leishmania infection by one or more of the following methods: parasitological examination (direct examination or culture), histopathology, immunohistochemistry or molecular test; consentiment form signed; availability for the schedule of the study	Women in reproductive age with positive (serum) pregnancy test at the time of screening; or lactating women; or women who can not or will not use contraception during and for up to 3 months after discontinuation of treatment; Carriers of HIV infection or other immunodebilitating condition; hepatic enzimes levels 3 times above the upper limit of normal, according to reference values; previous treatment for LM in the 6 months prior to study inclusion; previous treatment with leishmanicidal drugs indicated for the treatment of other diseases in the last six months prior to inclusion;use of medications that interfere with the therapeutic response or that cause interactions with drug of the study;  A history of hypersensitivity to the drugs being tested; renal, cardiac, hepatic or psychiatric disease that at the discretion of the investigator represents a contraindication to the use of some of the treatment alternatives included in this study; disseminated leishmaniasis concomitant with mucosal involvement; intravenous drug users or other chemical dependencies; Sjogren-Larson syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-9mmxqz9	Comparison of the effect between different Physical Recovery Techniques on Pain, Fatigue, Biochemical Substances and Function of Crossfit athletes® after a workout: A Randomized Controlled Trial	Recruitment completed	Intervention	2021-10-01	<NULL>	<NULL>	4933	Comparison of effectiveness between different Recovery Techniques about Pain, Fatigue, Biochemical Markers and Function of Crossfit® athletes after a workout: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-04	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9mmxqz9	<NULL>	Individuals who are training, with regular practice of at least 6 months and with weekly training frequency less of 3 times a week.	Those who have any type of medical condition such as dysfunctions in metabolism or the cardiorespiratory system, injuries to the limbs that prevent them from participating in both the evaluations and the procedures or those who abandon the study during any of the procedures will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-44g8vn	Comparison of the effect of Cicloergometro and physiotherapeutic exercises in patients with Chronic Renal Disease under treatment	Recruiting	Intervention	2018-05-03	<NULL>	<NULL>	1750	Comparison of the effect of Cicloergometry and Conventional Physiotherapy in patients with Chronic Renal Disease in Dialytic Treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-12	Universidade Federal de Alfenas UNIFAL-MG	Hospital Casa de Caridade Alfenas Nossa Senhora do Perpétuo Socorro	https://ensaiosclinicos.gov.br/rg/RBR-44g8vn	<NULL>	"Inclusion criteria: both genders; individuals within the age group
20 to 70 years; patients from the Hospital Casa de Caridade Alfenas Nossa Senhora do Perpétuo Socorro, Hemodialysis (HD) sector, submitted to HD three times a week."	Exclusion criteria: hemodynamic instability; pathological fractures; cognitive deficit or incoordination to run the apparatus used; Diabetes Mellitus and Systemic Arterial Hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-6d8whb5	Comparison of the effect of Conventional and Laser Cataract Surgery on the eye of Diabetic patients	Recruitment completed	Intervention	2022-05-17	<NULL>	<NULL>	5397	Comparative analysis of corneal endothelial cell loss among Diabetic patients undergoing Conventional Phacoemulsification and Femtosecond Laser-Assisted Cataract Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Hospital Oftalmológico Visão Laser	Hospital Oftalmológico Visão Laser	https://ensaiosclinicos.gov.br/rg/RBR-6d8whb5	<NULL>	Cataracts with nuclear density 2+ and 3+ graded by the Lens Opacity Classification System III (LOCS III)	Traumatic cataract; mature and hypermature cataracts; grade 4 nuclear cataract; pseudoexfoliation syndrome; conjunctival scar; significant corneal opacity; glaucoma; ocular hypertension; uveitis; vitreoretinal pathology; previous intraocular surgery; intraoperative complications during cataract surgery; collagen vascular disease; any active eye disease; high myopia; high hyperopia (axial length less than 15 mm); age under 40 years; preoperative cell count less than 1,000 cells per square millimeter or preoperative anterior chamber depth less than 2.5 mm; dry eye syndrome; neovascularization of the iris.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-97vkx4	Comparison of the effect of hyaluronic acid injection versus extracorporeal shockwave therapy on chronic plantar fasciitis: a randomized controlled trial	Not yet recruiting	Intervention	2020-07-22	<NULL>	<NULL>	4092	Comparison of the effect of hyaluronic acid injection versus extracorporeal shockwave therapy on chronic plantar fasciitis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Instituto Prevent Senior	Instituto Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-97vkx4	<NULL>	Healthy volunteers; chronic pain; plantar fasciitis; age over 18 years	Neuropathy; skin lesions; degenerative lesions; previous allergy to sodium hyaluronate; allergies to avian proteins; collagen disorders; rheumatoid arthritis; seronegative arthritis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-7528x4	Comparison of the effect of Hypnosis and Electrostimulation on pain control in patients with Chronic Low Back Pain	Recruiting	Intervention	2018-07-12	<NULL>	<NULL>	1999	Comparison of the effect of two analgesic techniques on pain control in patients with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-11	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7528x4	<NULL>	Chronic low back pain	are performing physiotherapeutic treatment by electroanalgesia, regardless of the current used; having a cardiac pacemaker; pregnant women; individuals who have performed surgical procedures in the spine; individuals who use analgesic drugs twenty-four hours (24 hours) before the interventions; individuals who present contraindication to cold	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-5tvjs5t	Comparison of the effect of intense interval exercise with moderate interval training on physical capacity and quality of life in patients with post covid -19 syndrome: a comparative study	Recruitment completed	Intervention	2022-02-11	<NULL>	<NULL>	7655	Training effect of high intensity interval training versus moderate intensity continuous training in functionality and life of quality of post-covid19 syndrome patients: a randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5tvjs5t	<NULL>	Patients of both sexes; aged from eighteen to sixty-five years old; with post covid syndrome19; with previous diagnosis of SARS CoV 2 infection by positive reverve transcription polymerase chain reaction for SARS-CoV-2 in combined nasopharyngeal swab molecular test examination of nasal and pharyngeal swab specimens or diagnosis according to computed tomography evidence from at least four weeks prior to admission to the post covid center; medical clearance to exercise	Orthopedic, neurological, or muscular limitations that prevent the adequate performance of physical exercise; Report of angina or previous coronary disease; Uncontrolled hypertension; Heart failure; Previous uncompensated pulmonary disease; Significant aortic stenosis; Active pericarditis or myocarditis; Uncontrolled atrial or ventricular arrhythmias; Third degree atrioventricular (AV) block without pacemaker; Patients who have had radiotherapy and/or chemotherapy in the last 6 months; Signs of embolism or acute thrombophlebitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-62hsp9	Comparison of the effect of interdental toothbrush and waterpik in the cleaning around dental implants in patients wearing fixed implant-supported prothesis	Recruiting	Intervention	2018-10-02	<NULL>	<NULL>	2260	Comparison of the efficacy of manual interdental toothbrush and waterflosser in the periimplantar cleaning in patients rehabilitated with fixed implant-supported prothesis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-62hsp9	<NULL>	Individuals rehabilitated with mandibular implant-supported prothesis (4 to 5 implants) type &quot;Branemark protocol&quot;; from both genders; age between 25 and 65 years; agreeing to sign the Written Informed Consent	smokers or former-smokers; individuals diagnosed with diabetes and / or immunological diseases; pregnant or lactating women; systemic use of antibiotics or anti-inflammatory drugs in the last three months; individuals requiring the use of prophylactic antibiotics for treatment; individuals who regularly or have used any type of mouthwashes in the last three months; individuals who refuse to sign an Informed Consent; patients who during the study refuse, give up or have difficulty in practicing the proposed method of oral hygiene; patients who during the study need antibiotic therapy due to any reason.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-7xz8bvw	Comparison of the effect of Laser protocol and Cryotherapy on the occurrence of postoperative pain in inflamed molar teeth	Not yet recruiting	Intervention	2024-08-05	<NULL>	<NULL>	7176	Comparison of the effect of Photobiomodulation protocol and Cryotherapy on the occurrence of postoperative pain and on the success of endodontic treatment in molar teeth with Irreversible pulpitis. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-07	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-7xz8bvw	<NULL>	Capable adult patients; aged between 18 and 65 years; both genders; who already have an indication for endodontic treatment in permanent molar teeth; diagnosed with irreversible pulpitis, confirmed by a positive response to clinical, electrical sensitivity and radiographic tests; have a contact number (telephone or cell phone or username on social networks) to be able to carry out postoperative evaluations	Patients who are at any stage of pregnancy. Patients who have been taking any medication such as analgesics or anti-inflammatories in the last 48 hours or who are immunocompromised, as these factors may alter the perception of pain or interfere with the analysis of the post-treatment pain score. Patients who have teeth with endodontic complications, such as: calcifications, external or internal resorption, partial formation of the apex, with dental perforations, with longitudinal or vertical fractures or with severe periodontal disease. During the endodontic procedure, patients who cannot have the endodontic treatment completed in the same session, or those patients who for any reason cannot be contacted to perform the outcome assessment will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-67xwg78	Comparison of the effect of Suprascapular Nerve Block associated with Physiotherapy and Physiotherapy alone in the treatment of frozen shoulder	Withdrawn	Intervention	2023-01-02	<NULL>	<NULL>	5795	Comparison of the effectiveness of Suprascapular nerve block associated with Physical therapy and Physical therapy alone in the treatment of Primary rigid shoulder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-13	Clínica de  Fraturas	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-67xwg78	<NULL>	Patients with a painful shoulder of spontaneous onset; accompanied by progressive limitation of glenohumeral movement in all directions; including at least 50% reduction in external rotation; not subjected to previous treatment; and confirmation by magnetic resonance imaging characterized by hypersignal of the inferior joint capsule greater than 4 mm; decreased filling of the axillary recess and edema in the rotator interval; age between 20 and 60 years.	Secondary rigid shoulder; patients already treated for rigid shoulder prior to the study; absence of magnetic resonance to confirm the diagnosis; patients with type I diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-6zfzs4j	Comparison of the effect of three Benznidazole formulations for the treatment of Chagas Disease	Data analysis completed	Intervention	2025-09-30	<NULL>	<NULL>	8327	Comparative bioavailability study of three Benznidazole formulations after ingestion of a specific meal - STPh 02/22	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2022-10-01	Scentryphar Pesquisa Clínica Ltda	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6zfzs4j	<NULL>	Healthy volunteers; both genders; aged 18 to 50 years; body mass index between 19 and 30 kg/m²; willing to use condoms during the study and up to 7 days after the last dose of the medication; able to understand the nature and purpose of the study, including risks and adverse events	Pregnancy; breastfeeding; smoking; history of alcohol or drug abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-32b22n	Comparison of the effect of two different irrigation methods on pain that occurs after root canal treatment	Recruiting	Intervention	2020-03-04	<NULL>	<NULL>	3560	Postoperative Pain after use of two different Final Irrigation protocols: A randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade de São Paulo - Faculdade de Odontologia de Bauru	Centro Especializado de Odontologia - Prefeitura Municipal de Vitória da Conquista	https://ensaiosclinicos.gov.br/rg/RBR-32b22n	<NULL>	Single root canals teeth; diagnosed with pulp necrosis and evidence of apical periodontitis; with radiolucency not exceeding 4 mm in diameter	Patients who have one or more of the following conditions: systemic disease; pregnant women; allergies to local anesthetics; presence of severe or acute pain; acute apical abscess; use of analgesic, anti-inflammatory, or antibiotic for 7 days prior to treatment; periodontal pockets greater than 4 mm associated with the referred tooth; teeth with subgingival caries that make absolute isolation difficult; and a history of unfinished endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-5fxbqsf	Comparison of the Effect of two Suturing Techniques after Extraction of mandibular Third molars	Recruiting	Intervention	2022-12-21	<NULL>	<NULL>	5771	Comparison of the Effect of two Suturing Techniques on inflammatory signs after Extraction of mandibular Third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade de Pernambuco	Faculdade de Odontologia da Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5fxbqsf	<NULL>	age between 18 to 30 years; present surgical site without current signs and symptoms of infection; present mandibular third molars in similar positions and with indication for extraction	history of pregnancy or lactation; history of allergy to any medication used in the experiment; not participating in all phases of the proposed research; systemic disease; making use of medications that interfere with the procedure on the day or week prior to the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-37jpt3	Comparison of the effect the lysine clonixinate (Dolamin ®) and ibuprofen (Advil ®) in reducing pain in patients with tendinopathy	Data analysis completed	Intervention	2014-09-16	<NULL>	<NULL>	335	A Randomized single-blinded, parallel group and unicentric Phase IV Clinical Study of non-inferiority, comparing the drug Lysine Clonixinate (Dolamin®) and Ibuprofen (Advil®) in reducing acute pain related to tendinopathy in patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2012-05-23	CREB-Centro de Reumatologia e Ortopedia Botafogo Sociedade Simples LTDA	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-37jpt3	<NULL>	"Volunteers be carrying from acute pain related to tendinopathy (tendinitis, tenosynovitis and bursitis of the shoulders, wrists / hands, knees and ankles / feet and require immobilization;
age between 18 and 65 (sixty five) years; Indicate, in max, grade 7 in the Visual Analogue Scale (VAS) of pain; Having signed and dated the &apos;Informed of Consent Form&apos; (ICF) specified for this study, prior to any participation in procedures related to it."	"None of the patients included in this study should be carrying from acute pain related to tendinopathy at the hip; having a history of asthma or bronchospasm, nasal polyps, allergic reactions and / or induced by acetylsalicylic acid (aspirin) or other anti-inflammatory drugs; history of gastrointestinal bleeding due to the use of NSAIDs; is receiving treatment with other anti-inflammatory drugs, corticosteroids or analgesics; Is receiving treatment with oral anticoagulants, ticlopidine, heparin and thrombolytics; be pregnant and / or lactating; be hypersensitive (allergic) to any of the components of the formula;
8. Be a regular user of alcohol and barbiturates; have hepatic or renal impairment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-639bff	Comparison of the effectiveness of sweetened solution and foot massage in relieving pain in infants admitted to a neonatal intensive care unit	Not yet recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3504	"Comparison of eficacy of glucose and
reflexotherapy in newborn pain relief in Neonatal Intensive
Therapy Unit: A clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-27	Daniele Vieira Dantas	Daniele Vieira Dantas	https://ensaiosclinicos.gov.br/rg/RBR-639bff	<NULL>	The inclusion criteria of the research are Newborns equal to or greater than 32 weeks of gestation or weighing 1500g or more undergoing exam collection 12-hour laboratory tests / blood gas analysis / blood culture through arterial puncture.	Neonates diagnosed with perinatal asphyxia (Apgar score less than 5 in 5 minutes); which do not show reflex who are using analgesics or sedatives; with malformations congenital disorders, syndromes and neurological manifestations; the son of women drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-2k3kbq	Comparison of the effectiveness of the use of pads in adult patients admitted to the Intensive Care Unit	not yet recruiting	Intervention	2012-03-07	<NULL>	<NULL>	156	Comparison of the effectiveness of the use of pads in adult patients with diagnoses of hyperthermia admitted to the Intensive Care Unit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Escola de Enfermagem Universidade Federal de Minas Gerais	Hospital Municipal Odilon Behrens	https://ensaiosclinicos.gov.br/rg/RBR-2k3kbq	<NULL>	"For inclusion of patients in this study will be established the following criteria: 
be over 18 years;
body temperature 38.3 ° C;
to consent to participate in the survey or have authorized their participation by signing the Statement of responsibility Consent"	"Exclusion criteria are: 
patient or guardian does not agree to sign the Instrument of Consent;
patients with severe heart disease, traumatic brain injury, malignant hyperthermia, pregnant women, which has a history of adverse reactions following the use of physical methods (hot or cold) in the reduction of body temperature and do not tolerate treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-5ky3ks	Comparison of the effectiveness of therapy  bromopride,metoclopramide,e ondasetron  Intramuscular for treatment of vomiting	Recruitment completed	Intervention	2015-01-21	<NULL>	<NULL>	374	Randomized  clinical trial, comparing the effectiveness of therapy bromopride, metoclopramide and ondansetron intramuscular for treatment of vomiting	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2013-08-01	União Brasileira de Educação e Assistência	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5ky3ks	<NULL>	children who have experienced two or more episodes of vomiting in the last 24 hours, aged 1 year to 12 years, both genders; medical indication for receiving intramuscular antiemetic; when the country or guardians agree with the inclusion of a dependent in the study	bromopride known allergy to metoclopramide and ondansetron; vomiting due to sedation, anesthesia or chemotherapy; teenagers pregnant and / or breastfeeding; heart disease, advanced renal disease, urinary tract infection, epilepsy, intestinal obstruction, appendicitis, meningitis and diabetes mellitus, malnutrition, pneumonia, brain tumor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-2cwq2pr	Comparison of the effectiveness of two local anesthetics in tooth extractions	Recruiting	Intervention	2022-12-23	<NULL>	<NULL>	5776	Comparison of the vestibular anesthetic effectiveness of lidocaine and articaine in upper third molar exodontics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Éwerton Daniel Rocha Rodrigues	Faculdade de Odontologia da Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2cwq2pr	<NULL>	Age between 18 and 30 years; present surgical site without current signs and symptoms of infection; present maxillary third molars in similar positions and with indication for extraction.	history of pregnancy or lactation, with a history of allergy to any drug used in the experiment; who are using drugs that alter bone metabolism; do not participate in all phases of the proposed research; use medications that interfere with the procedure on the day or week prior to the research, such as antibiotics , corticosteroids and non-steroidal anti-inflammatory drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-9d26qz7	Comparison of the effects of antibiotic use on pain and infection symptoms after lower third molar removal surgery: a randomized, triple-blind clinical trial	Recruitment completed	Intervention	2026-04-07	<NULL>	<NULL>	9063	Comparison of the clinical effects of postoperative antibiotic therapy in the prevention of local and systemic infections after third molar surgeries: a randomized, triple-blind clinical study	<NULL>	2, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Obras Sociais e Educacionais de Luz	<NULL>	<NULL>	<NULL>	Patients of both genders; aged between 18 and 35 years; who do not present Local or Systemic Pathologies; having impacted lower third molars that require Osteotomy and/or Odontosection	Patients who are allergic to the medications used in the study; individuals who were not interested in participating in the research; diagnosis of Cardiac Diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-7d4c99f	Comparison of the effects of Dexamethasone and Non-Steroidal Anti-inflammatories in the post-operative Removal of wisdom teeth	Terminated	Intervention	2024-10-29	<NULL>	<NULL>	7463	Comparison of the effects of Dexamethasone and Non-Steroidal Anti-inflammatories in the post-operative Removal of third molar extractions: randomized and triple blind clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Santo Amaro	Universidade Santo Amaro	https://ensaiosclinicos.gov.br/rg/RBR-7d4c99f	<NULL>	They presented good systemic health conditions (ASA I); were between 18 and 35 years of age of both sexes; were indicated for extraction of the 38 and/or 48 impacted or semi-impacted dental elements, requiring a total mucoperiosteal flap and osteotomy	Patients who did not meet these inclusion criteria; who had any local inflammatory or infectious condition that would contraindicate tooth extraction; any type of hypersensitivity reaction to the medicinal substances that were used in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-10266kdp	Comparison of the effects of High Intensity Functional Training carried out online and the same training carried out in person on risk factors for the health of physically inactive women over 50 years old	Data analysis completed	Intervention	2021-10-07	<NULL>	<NULL>	4949	Effects of High-Intensity Functional Training conducted at home via web classes and face-to-face training on cardiometabolic risk factors in sedentary women over 50 years old	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10266kdp	<NULL>	Sedentary women; non smokers; Age between 50 and 65 years old; not being a carrier of incapacitating clinical conditions or heart problems that make it impossible to practice physical exercise; agree to participate in 36 training sessions during the 12 weeks	Show changes in cardiological examinations; diagnosis of chronic obstructive pulmonary disease; angina; uncontrolled cardiac arrhythmias; severe congestive heart failure; chronic kidney disease; liver failure; severe orthopedic problems; neurological diseases; being a chronic tobacco and/or alcohol user; change in the use of medications during the study period; failure to meet the inclusion criteria;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-4hv9rs	Comparison of the effects of Inspiratory Muscle Training and Aerobic Training in people on Hemodialysis	Data analysis completed	Intervention	2015-06-08	<NULL>	<NULL>	1493	Comparison of the effects of Inspiratory Muscle Training and Aerobic Training of the lower limbs in physiological and functional parameters in Hemodialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-09	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4hv9rs	<NULL>	Were included patients with chronic kidney disease on hemodialysis for longer three months and weekly frequency of three times a week;  hemodialysis access by arterio-venous fistula.	Systolic blood pressure greater than 180 mmHg or diastolic blood pressure greater than 120 mmHg,  ischemic heart disease, recent myocardial infarction (less than 6 months), complex ventricular arrhythmia, aortic stenosis, severe metabolic disease, severe anemia and aortic aneurysm; respiratory diseases, neurological or musculoskeletal that compromises the protocol execution; inability to perform any stage of protocol; absence in three consecutives exercise sessions; changes of clinical treatment during study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-23nyf4	Comparison of the effects of Mental Practice protocols for Functional Mobility and Risk of Falls in Parkinson&apos;s disease	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1555	Mental Practice protocols for Functional Mobility and Risk of Falls in Parkinson&apos;s disease: A Randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-23nyf4	<NULL>	"Patients with clinical diagnosis of idiopathic Parkinson&apos;s disease according to Ordinance No. 228/2010 of the Ministry of Health of Brazil;
Both sexes;
Patients aged 18-80 years;
Stage 1 to 3 of Hoehn and Yahr&apos;s original scale."	Other neurological diseases; orthopedic, rheumatic and / or vascular pathology, with moderate or severe functional restriction in one or both lower limbs; uncontrolled hypertension and / or cardiac or respiratory disease that limits the execution of the protocol; with lowering of the cognitive level; with medical restriction to perform exercises; unable to perform the motor imagination, in physical therapy or occupational therapy for 3 months or more; with moderate to severe depression; with visual and auditory deficits that do not guarantee a good participation in the protocol; after deep brain stimulation surgery; with vestibular alterations; with lack of sensitivity in the lower limbs; users of orthosis for lower limbs; User of prosthetics; with edemas in the lower limbs and amputees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-77mwqf	Comparison of the effects of Myofascial Release Technique on the pressure pain threshold and range of motion in individuals with restricted neck movement	Recruitment completed	Intervention	2020-02-17	<NULL>	<NULL>	3496	Comparison of the effects of Passive and Active Myofascial Release Technique on the pressure pain threshold  and range of motion in individuals with cervical mobility restriction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-13	Vítor Dias Ferreira	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-77mwqf	<NULL>	Individuals of both sexes; between 18 and 50 years old; with no complaints of cervical pain in the last two weeks and with a cervical range of motion difference of at least 10 ° between right and left sides for rotational movement.	History of trauma; injuries or surgery in the cervical region; contraindications to receiving manual therapy such as infections and active inflammations; neoplasms; deep vein thrombosis; skin changes; congenital anomalies; presence of symptoms such as hypotension; fever; nausea; lethargy; flushing and edema in the region of application of the technique; use of analgesic medication in the last 48h and have received myofascial release technique in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-7g6qq8	Comparison of the effects of oral and intramuscular use of corticosteroids on pain, swelling and mouth opening and closing movements after extraction of the wisdom tooth	Data analysis completed	Intervention	2019-03-25	<NULL>	<NULL>	2539	Comparative study of the effectiveness of two routes of corticosteroid administration to control edema, trismus and pain after surgical extraction of impacted third molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-27	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7g6qq8	<NULL>	The inclusion criteria were: healthy subjects, aged over 16 years of either sex, without contraindications for corticoid treatment, no history of pericoronitis for the last 6 months, no history of recent illness that required medications that could alter the inflammatory response, no use of medication that could interfere with the healing process and who required extraction of all four third molars. The extractions were all of similar technical difficulty and orthopantomography showed positioning and depth of impaction to be symmetrical in each arch. All patients required ostectomy and tooth sectioning of the lower third molar to achieve extraction. The difficulty was determined by means of the Pell and Gregory classification.	"Occurrence of post-operative local infection
 Failure to attend second surgical procedure"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-4596xc2	Comparison of the effects of prescribed physical exercise after an evaluation performed using a treadmill walk test versus the Six-Minute Walk Test in a corridor in patients with coronary artery disease: a randomized controlled clinical study	Not yet recruiting	Intervention	2025-04-27	<NULL>	<NULL>	7959	Comparison of the adaptations induced by physical training prescribed based on the cardiopulmonary exercise rest and the six-minute walk test in patients with coronary artery disease: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-30	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4596xc2	<NULL>	Volunteers diagnosed with coronary artery disease; over 18 years old; no restrictions regarding gender	Volunteers with contraindications for moderate physical training; contraindications for performing any of the assessment methods; orthopedic limitations; non-adherence to pharmacological treatment; non-adherence to the cardiovascular rehabilitation program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-3yyd4jd	Comparison of the effects of the Invisalign Palatal Expander (IPE) and the Hyrax Expander in the treatment of narrow maxilla	Not yet recruiting	Intervention	2025-06-26	<NULL>	<NULL>	8069	Effects of treatment of Maxillary Atresia in the mixed dentition with the Invisalign Palatal Expander (IPE) system and Hyrax expander: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Anhaguera - UNIDERP	Universidade Anhaguera - UNIDERP	https://ensaiosclinicos.gov.br/rg/RBR-3yyd4jd	<NULL>	Ages 7 to 10 years; both sexes; Angle Class I malocclusion; presence of maxillary atresia; erupted upper and lower permanent incisors	Patients with craniofacial deformities; dental agenesis; history of previous orthopedic/orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-8b3wfmb	Comparison of the effects of three Physical Training protocols in asthmatic children	Not yet recruiting	Intervention	2026-03-27	<NULL>	<NULL>	9025	Comparison of the effects of three Physical Training protocols on clinical outcomes of children diagnosed with Asthma	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade Estadual de Londrina - UEL	<NULL>	<NULL>	<NULL>	Individuals aged between eight and 12 years; of both sexes; with a clinical diagnosis of asthma; who correctly use medication for control; do not practice physical exercise (except in school physical education); and who do not present cognitive, systemic, and motor alterations that could limit the performance of the study	Not completing all assessments; requiring hospitalization or abandoning the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-2hx7p2	Comparison of the effects of two anesthetic protocols on the glycemic levels of patients undergoing extraction.	Recruiting	Intervention	2016-12-21	<NULL>	<NULL>	1109	Comparison of the effects of 2% lidocaine solutions with adrenaline 1: 100,000 and prilocaine 3% with felipressin 0.054 iu / ml in concentrations of blood glucose during exodontia.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-26	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2hx7p2	<NULL>	Patients older than 18 who will sign the TCLE; Medication-controlled diabetes mellitus; Patients in need of a simple exodontia in the mandible region using as an anesthetic technique the blockage of the inferior and buccal alveolar nerve; Surgical difficulties similar.	Patients under 18 years of age; Any general health problems, based on medical history and physical examination;History of use of any type of medicine in the 15 days prior to the beginning of the research;History of hypersensitivity to drugs, substances or materials used in this experiment;Pregnancy or lactation;Anatomical location of the tooth unfavorable to the inferior alveolar and buccal nerve block.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-10gqsbsm	Comparison of the effects of two breathing aids, the high-flow nasal cannula and the venturi mask, on exercise tolerance in lung transplant candidates	Data analysis completed	Intervention	2023-05-24	<NULL>	<NULL>	6102	Comparison of the effects of high-flow nasal cannula and venturi mask on exercise tolerance in lung transplant candidates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-22	Hospital de Messejana Dr Carlos Alberto Studart Gomes	Hospital de Messejana Dr Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-10gqsbsm	<NULL>	Lung transplant candidates; both genders; older than 18 years; in initial evaluation for inclusion in a pulmonary rehabilitation program; with oxygen dependency or need for oxygen supplementation during the symptom-limited incremental load test performed before inclusion in the study	Candidates who did not comply with the protocol, because they were absent on the assessment day; candidates who did not present clinical conditions on the day of the test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-3t3z37t	Comparison of the effects of two suspension training protocols on the pain and musculoskeletal function of individuals with chronic low back pain	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8419	Comparison of the effects of two suspension training protocols on pain and skeletal muscle function of individuals with chronic low back pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-10	Universidade Federal do Paraná	Centro de Estudos em Prescrição Clínica do Exercício (CEPREX)	https://ensaiosclinicos.gov.br/rg/RBR-3t3z37t	<NULL>	Volunteers with chronic, nonspecific, persistent, or periodic low back pain; military personnel; age range between 18 and 59 years; pain intensity greater than 3 on the numerical pain scale; moderately active according to the Human Activity Profile Questionnaire.	Body mass index greater than or equal to 30 kg/m2; no physiotherapy treatment concurrent with the study period; no surgery in the lumbar region; no clinical diagnosis of low back pain; no low back pain radiating to the glutes and lower limbs; use of medication for low back pain relief 48 hours before performing the exercises; previous diagnosis of heart disease; neurological disease; uncontrolled hypertension (less than 1 year after starting medication); acute lung disease; orthopedic injuries; failure to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4tfwdhp	Comparison of the effects of walking in a suggested environment and free walking for people with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2023-08-21	<NULL>	<NULL>	7352	Ecological determinants of active behavior of people with Chronic Obstructive Pulmonary Disease and effects of walkability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-29	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4tfwdhp	<NULL>	Individuals with a confirmed diagnosis of Chronic Obstructive Pulmonary Disease (COPD) will be studied based on the criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD); of both sexes; with the post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio being &lt;70% and FEV1 &lt;80% of the predicted value 29; aged over 18 years; clinically stable; without unstable cardiovascular diseases; neurological; musculoskeletal disorders and in conditions to carry out the proposed evaluations and intervention	Participants unable to perform or understand the study assessments due to physical or psychological impairment will be excluded from the study; primary diagnosis of a respiratory disease other than Chronic Obstructive Pulmonary Disease (COPD); in support of oxygen therapy; with orthopedic and/or neurological limitations that prevent the performance of the tests; recent hospitalization (last 3 months); cognitive impairment identified by a score of 4 or less on the Six Item Screener; or who expressed their desire to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-27fpmt	Comparison of the efficacy and safety of surgical laser with electrocautery in the treatment of gingiva increase by denture	Recruiting	Intervention	2018-03-02	<NULL>	<NULL>	1673	Comparison of the efficacy and safety of diode surgical laser with electrocautery in the treatment of inflammatory fibrous hyperplasia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade federal de Minas Gerais	Universidade federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-27fpmt	<NULL>	Healthy volunteers; age greater than 18 years; both genders; with clinical diagnosis inflammatory fibrous hyperplasia.	Volunteers using analgesic medication; with systemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-7zdb29p	Comparison of the efficiency of different materials used in the manufacture of dental aligners	Recruiting	Intervention	2025-10-08	<NULL>	<NULL>	8380	Comparative evaluation of the effectiveness of orthodontic aligners made with different types of materials	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zdb29p	<NULL>	Mild to moderate Class I or II malocclusion (maximum 1/4 of Class II); age range between 18 and 35 years; both sexes; presence of all permanent teeth except the 3rd molars; mild to moderate degree of model discrepancy (from 2 to 6 mm); absence of skeletal crossbite	Severe periodontal diseases; lack of cooperation or adherence to treatment; presence of extensive prosthetic crowns; tooth shape anomalies; tooth fractures; active caries lesions; systemic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-9qrsf8	Comparison of the Erector Spinae plane block in pulmonary surgeries in relation to Paravertebral block	Not yet recruiting	Intervention	2020-08-12	<NULL>	<NULL>	4114	Comparison of analgesia of Erector Spinae plane block in pulmonary surgeries in relation to Paravertebral block: a randomized multicenter study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - HCFMRP	IAMSPE - Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9qrsf8	<NULL>	Patients over 18 years of age undergoing unilateral pulmonary surgery under thoracotomy or thoracoscopy approach.	Patients who refuse participation. Severe puncture site infection or deformity. Coagulation disorder (INR greater than 1.4 or use of anticoagulant medications and platelet count less than 100,000 / mm3). Body mass index greater than 35kg / m2. Renal impairment (creatinine clearance less than 30 ml/min). Failure to operate the PCA system or to sign the informed consent form. Patients undergoing bilateral surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-10xtk662	Comparison of the excretion of flavonoids of orange juice by obese and non-obese	Recruitment completed	Intervention	2021-09-08	<NULL>	<NULL>	4867	Comparative study of the excretion of orange flavonoids, cv. Pera and cv. Moro juices, between lean and obese individuals	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2017-07-12	Faculdade de Ciências Farmacêuticas	Faculdade de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-10xtk662	<NULL>	No history of gastrointestinal, hepatic or renal disease;Do not be an alcoholic;Do not be diabetic;Do not be a vegetarian;Do not present any type of infection;Not be making use of vitamin and mineral supplements;Do not be a smoker;Do not practice intense physical activity;They can not be pregnant, breastfeeding or reporting hormone therapy for menopause	Be under 19 and over 40 years old;Do not be female;Have intestinal, kidney or liver disease;Being a vegetarian or a smoker;Practice intense physical activity;Being pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-3w2p32	Comparison of the fake effect among non-penetrating acupuncture devices and real acupuncture	Recruitment completed	Intervention	2016-01-28	<NULL>	<NULL>	900	Comparison of the placebo effect among non-penetrating acupuncture devices and real acupuncture in healthy subjects: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Núcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe	Hospital Universitário (HU) da Universidade Federal de Sergipe (UFS)	https://ensaiosclinicos.gov.br/rg/RBR-3w2p32	<NULL>	Healthy individuals; both sexes; that and understand Portuguese; no previous experience with acupuncture; without sensitivity to change; which has not undergone surgery in the last 6 months.	Pregnant and postpartum women who gave birth in the last 3 months; prick skin lesions in the region; infectious process assets; nervous or dermal tissue disease affecting the region of the puncture; inability to understand the instructions or consent to the study; psychiatric diseases; presence of hearing impairment, visual or communication; or even have cognitive impairment / moderate or severe psychiatric.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-8cj7smm	Comparison of the immediate effects of transcranial electrical stimulation with different current patterns on cortical metrics among healthy individuals, with ADHD and depressive symptoms	Recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7963	Comparison of the immediate effects of transcranial electrical stimulation with different current patterns on cortical metrics among healthy individuals, with ADHD and depressive symptoms	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-30	Instituto de Ciências da Vida da Universidade Federal de Juiz de Fora - ICV UFJF GV	Instituto de Ciências da Vida da Universidade Federal de Juiz de Fora - ICV UFJF GV	https://ensaiosclinicos.gov.br/rg/RBR-8cj7smm	<NULL>	Young adults; men and women; between 18 and 30 years old; with hearing acuity; no self-reported use of psychoactive substances	Individuals with epilepsy; taking anticonvulsant medication and/or sleep deprivation; with photosensitivity; with a history of seizures for any reason; with metallic materials implanted in or near the head; with pacemakers or cardiac wires (Stents) or with another active device in which interaction with the electric field may interfere with its functioning; participants with eczema on the head will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-7wrfjn8	Comparison of the motor response time of the upper and lower limbs of people with Down Syndrome when performing an activity on the computer	Recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7057	Comparison of the reaction time of the upper and lower limbs of individuals with Down Syndrome during a computational task	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-11	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7wrfjn8	<NULL>	Individuals with a clinical diagnosis of Down Syndrome and individuals with typical development (to make up the Control Group); of both sexes; from eight years of age will be included	Individuals who do not carry out the proposed activities due to lack of understanding or other factors; individuals with an associated diagnosis of Autism Spectrum Disorder (ASD) or Oppositional Defiant Disorder (ODD); in addition to withdrawal during the protocol; children and young people with low vision or blindness and vestibular pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-6bv5hy	Comparison of the occurrence of pain after root canal treatment performed on teeth with mortified nerve with or without injury to the root of the tooth using two mechanized canal cleaning systems and two canal cleaning limits.	Data analysis completed	Intervention	2019-11-06	<NULL>	<NULL>	3169	Comparison of postoperative pain incidence in endodontic treatments performed on Pulp Necrosis teeth with or without apical lesion using two mechanized instrumentation systems and two apical instrumentation limits	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6bv5hy	<NULL>	Inclusion criteria were teeth diagnosed with asymptomatic necrosis pulp; confirmed by a negative response to pulp vitality tests with heat and cold; with or prior radiographic periapical lesion and without clinical symptoms such as pain; fistula; edema and palpation sensitivity.	We excluded from the study vital teeth, previous endodontic retreatment; teeth with open apex; teeth with periodontal problems that have periodontal probing greater than 3 mm; internal and external root resorption, dental traumatism; treatments not a single session; root canals where it was not possible to realize the patency of the apical foramen and patients allergic to some compound of the medicine ibuprofen. Also excluded were those with spontaneous pain that were included in the study; who used analgesic or anti inflammatory medication in the last ten days, who had systemic diseases and those who refused to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-57xv2xm	Comparison of the respiratory and analgesic effects of shoulder pain block in patients undergoing video shoulder surgery: a randomized clinical study	Recruiting	Intervention	2025-06-19	<NULL>	<NULL>	8061	Comparative randomized clinical study between brachial plexus block via interscalenic and costoclavicular via regarding respiratory and analgesic effects in patients undergoing shoulder arthroscopy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-57xv2xm	<NULL>	Age between 18 and 80 years, of both sexes, with an ASA score (American Society of Anesthesiologists) of 1 to 3, body mass index (BMI) between 20 and 35kg/m² undergoing elective arthroscopic shoulder surgery	Patients will be excluded from the study if they are unable to consent to the study, have neuropsychiatric diseases, cognitive impairment or altered mental status, pre-existing pulmonary disease (obstructive or restrictive), coagulopathy, sepsis, hepatic or renal failure (glomerular filtration rate less than 30ml/min), pregnancy, known or suspected allergy to medications used during anesthesia, chronic pain condition requiring the ingestion of opioids at home and previous surgery in the neck or infraclavicular region ipsilateral to the operated limb	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-5jznnt	Comparison of the results obtained in the exam that evaluates the functioning of the bladder with the clinical examination to try to find out if there is difficulty for women to urinate if they have a low bladder or other gynecological diseases	Recruiting	Observational	2018-05-23	<NULL>	<NULL>	1840	Comparison of the results obtained in the urodynamic exam in the flow / pressure study phase with urethral resistance analysis (free flowmetry, maximum detrusor pressure at maximum peak urinary flow and post void residue), with the classification of POP-Q (Pelvic Organism Prolapse Qualification), for the dystopias pelvicase with the quality of life questionnaire, validated for the Portuguese language, to standardize the diagnosis of infravesical obstruction in patients with Urinary Incontinence associated w	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Universidade Federal de São Paulo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-5jznnt	<NULL>	Patients with low urinary complaints.Patients who underwent the Urodynamic Study.Patients who signed the Informed Consent Form.	Patients with urinary infection at the time of the urodynamic study.Patients with Neurogenic Bladder.Patients who refused to sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-3g6dbt8	Comparison of the results of non-surgical treatments of clavicle fractures using a sling or immobilizer in eight	Not yet recruiting	Intervention	2023-04-14	<NULL>	<NULL>	6006	Conservative treatment of mid-shaft clavicle fractures, arm sling versus figure-of-eight immobilization. Randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-3g6dbt8	<NULL>	Volunteers with acute midshaft clavicle fractures (up to 10 days after the trauma); adults between 18 and 65 years old; no medical contraindications for the proposed treatments; acceptance and understanding of the informed consent form	Patients with proximal or distal clavicle fractures, fracture with deviation or shortening greater than 2 cm between the bone fragments in at least one of the radiographic views (AP or Zanca); pathological fracture; open fracture; associated neurovascular injury diagnosed on physical examination; head trauma (Glasgow &lt;12); fracture and/or dislocations in the ipsilateral upper limb; previous diseases in the affected limb that may influence the results; inability to maintain outpatient clinical follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-6d9657	Comparison of the results of two different types of acids on the face of women with oily and blemished skin.	Recruiting	Intervention	2017-07-28	<NULL>	<NULL>	1311	Comparison of effectiveness of chemical peeling of retinoic acid and mandellic acid on oleosity and acne hypercromy in adult women: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-25	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6d9657	<NULL>	Will be included female individuals, aged between 18 years and 48 years, with a phototype of I to IV and with complaint of hyperchromia after acne on the face verified by Baumman questionnaire	Pregnant and lactating women will be excluded who have is subjected to dermatological and / or cosmetic treatment in the face in the last 6 months, or who have active infection in the face (acne&gt; grade I), disease dermatological or metabolic causing hyperpigmentation of the face, such as Syndrome Cushing&apos;s and Lupus Systemic Eritrematoso or hyperpigmentation from birth as nevus. Similarly, those who miss session 01 any of the groups are excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-62p5rf	Comparison of the retraction of 3 Dermis Substitutes used to treat Burn Sequelae	Recruitment completed	Intervention	2018-06-12	<NULL>	<NULL>	1883	Prospective, randomized, controlled study of Burn Sequelae comparing late Retraction between three dermal matrices: Integra®, Matriderm® and Pelnac®	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-15	Hospital das Clínicas de Ribeirão Preto	Hospital das Clínicas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-62p5rf	<NULL>	Patients from the burn outpatient clinic of the Burn Unit of the HCFMRP-USP who had some chronic burn como sequela associated with aesthetic impairment; functional restriction; unstable scars or Marjolin&apos;s ulcer (carcinomatous degeneration); with at least 1 year post-burn follow-up ; in which surgical correction with partial skin graft was indicated.	Patients who lost a more than 10% of the partial skin graft, or patients who had any restrictions on the use of dermal matrix (such as allergy to any component present in the product), were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8m8754y	Comparison of the success of two antibiotic pastes used in root canal treatment without instrumentation	Not yet recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7088	Evaluation of the sucess rate of two antibiotic pastes used in lesion sterilization and tissue repair: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8m8754y	<NULL>	Children aged 3 to 11 years; no distinction between the sexes; with at least one deciduous molar diagnosed with irreversible pulpitis or pulp necrosis and internal or external resorption; sufficient tooth structure to allow absolute isolation of the operative field and rehabilitation with a stainless steel crown	Children who present any systemic alteration; history of allergic reaction to the components of the pastes to be studied; and have used antibiotics in the last three months from the date of the exam; patients with systemic manifestations (fever and extra-oral abscess) resulting from the infectious process of dental origin or teeth that present obliteration of the pulp canal; impairment of the bone crypt of the permanent tooth; coronary destruction that makes absolute isolation with a rubber dam and/or rehabilitation with a stainless steel crown impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-25ng5pt	Comparison of the use of a Biodressing and Laser Therapy for the treatment of Diabetic Foot Wounds	Not yet recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6686	Comparison between the use of a Biocuration and Low Intensity Laser Therapy in the treatment of Diabetic Foot Ulcers	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-03-31	Universidade Federal do Delta do Parnaíba	Universidade Federal do Delta do Parnaíba	https://ensaiosclinicos.gov.br/rg/RBR-25ng5pt	<NULL>	Volunteers of both sexes;aged over 18; with a clinical diagnosis of type 2 diabetes mellitus; diabetic ulcers located in the foot region;who agree to take part in the study by signing the Informed Consent Form (ICF)	Ulcers located in other regions of the body; who are unable to attend the treatment days proposed by the research; who are using other types of coverage for diabetic ulcers, which hinder the use of Laser and the identification of the results proposed by this research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-7ctn7pp	Comparison of the use of different volumes of Nasal Irrigation Solution in postoperative period of Nasal Endoscopic Surgery in patients with Chronic Sinusitis with Nasal Polyps	Recruiting	Intervention	2023-11-03	<NULL>	<NULL>	6561	Comparison of the use of different volumes of Saline Solution with Corticosteroids in postoperative period of Nasal Endoscopic Surgery in patients with Chronic Rhinosinusitis with Nasal Polyps	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7ctn7pp	<NULL>	We will evaluate patients in the immediate postoperative period of nasal endoscopic surgery due to Chronic Rhinossinusitis with Nasal Polyps. Patients aged 18 to 70 years who have bilateral disease and who have undergone at least anterior and posterior ethmoidectomy and bilateral maxillary antrostomy will be included	Patients with suspected systemic diseases with nasal involvement, such as cystic fibrosis and ciliary dyskinesia. Patients with exacerbations at the time of the surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-749vzfz	Comparison of the use of Mannitol vs Albumin in preventing the fall in Blood Pressure in patients with renal problems undergoing Prolonged Hemodialysis: a randomized controlled clinical trial	Recruiting	Intervention	2026-03-12	<NULL>	<NULL>	8970	Evaluation of the use of Mannitol and Albumin in the prevention of intradialytic hypotension in patients with Acute Kidney Injury undergoing Prolonged Hemodialysis: a randomized clinical trial	<NULL>	4, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Departamento de Suporte às Unidades de Saúde	<NULL>	<NULL>	<NULL>	Patients admitted to the Intensive Care Units (ICU) of the Hospital das Clínicas of the Faculty of Medicine of Botucatu; over 18 years of age; with Acute Kidney Injury associated with sepsis; in acute renal support therapy undergoing Hemodialysis; using norepinephrine at a dose of 0.2 to 0.6 ucg/kg/min and being monitored by the Acute Kidney Injury group of the nephrology service	Patients undergoing chronic renal replacement therapy (Chronic Kidney Disease dialysis and kidney transplant) and treated with less than two prolonged hemodialysis sessions will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-5g64wy4	Comparison of the use of Tens associated with Pilates in Chronic Low Back Pain	Not yet recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7266	Comparative analysis of association of Tens with the Pilates Method in Chronic Low Back Pain: randomized, sham-controlled and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-10	Centro de ciências da saúde da Universidade Federal da Paraíba	Centro de ciências da saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5g64wy4	<NULL>	Volunteers aged between 18 and 85 years old; of both sexes; with a primary diagnosis compatible with nonspecific low back pain (low back pain without other specification); with a pain intensity score of 3 or higher on the Numerical Rating Scale (NRS); who have not undergone previous surgery in the lumbar region; who have no skin lesions; who do not have a pacemaker; who have not used medication for low back pain relief within 48 hours prior to the intervention; who are not undergoing treatment for low back pain; and who agree to participate in the research by signing the Informed Consent Form	Develop a health disorder during the study. Present allergic reactions to the electrical current generated by the therapeutic resource	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-6y4r29	Comparison of thick and thin graft for root coverage	Recruitment completed	Intervention	2019-10-07	<NULL>	<NULL>	3040	The influence of subepithelial connective tissue graft thickness on root coverage outcomes. A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-11	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6y4r29	<NULL>	Pacients non- smokers, age &gt; 18 years old, no systemic diseases or conditions that could affect periodontal health or healing ( ASA 1 or ASA2 Only), no Periodontal  Disease,  good oral hygiene (full mouth plaque index, and gingival index &lt; 20%), identifiable cementum-enamel junction and able and willing to provide informed consent for the surgery and study.	Voluntary withdrawal , Non compliance with study protocol, smokers or former smokers, pregnancy or lactation, previous surgical root coverage treatment , recession defects associates with caries or restoerations, history of destructive disease  in the area of interest, systemic healing disorders ( e.g., AIDS, diabetes mellitus,tooth with deep extensive erosion or abrasion, tooth severely malpositioned that may cause papillae height loss(i.e. malposition, rotations and versions, occlusal interferences or without antagonist)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-2zk6yc	Comparison of three methods to measure the feeding tube in newborns	Data analysis completed	Intervention	2018-02-07	<NULL>	<NULL>	1636	Length of the gastric tube in newborns: comparison between three methods of measurement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Estadual de Campinas	Caism - Hospital da Mulher Prof. Dr. José Aristodemo Pinotti	https://ensaiosclinicos.gov.br/rg/RBR-2zk6yc	<NULL>	"Newborn; both genres; need a gastric tube; do not present any type of congenital malformation or syndrome; have not suffered
surgical procedure in the gastrointestinal system."	"newborn who is seriously ill; under minimal care; has a medical contraindication
of nasopharyngeal tube; severe hypothermia that prevents the X-ray, ultrasonography,
weighing and length verification."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-4zg9nwh	Comparison of three surgical approaches for removal of the right kidney for donation	Not yet recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8604	Open, laparoscopic, and robotic right donor nephrectomy: a prospective randomized study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Hospital das Clínicas da Faculdade de Medicina da USP - HC FMUSP	<NULL>	<NULL>	<NULL>	Patients aged &gt;18 years. Voluntary living kidney donors approved for transplantation by the institutional medical, ethical, and legal committees	Contraindications to laparoscopic or robotic approaches. Uncontrolled comorbidities. Refusal to provide informed consent. Left kidney donors	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-33mj49	Comparison of Tomography with Clinical and Surgical Evaluation in the Diagnosis of Bone Defects	Recruitment completed	Observational	2019-12-05	<NULL>	<NULL>	3252	Accuracy of Cone-Beam Computed Tomography in Defining the Type of Furcation Injury in Upper Molars	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade Federal de Goiás	UniEvangélica	https://ensaiosclinicos.gov.br/rg/RBR-33mj49	<NULL>	patients older than 18 years with periodontitis in upper molar teeth; who underwent previous non-surgical periodontal therapy and showed no improvement in periodontal disease.	Maxillary molars with furcation injury that simultaneously had caries; cervical resorption; fused roots; metallic crowns or amalgam restorations near the alveolar bone crest; Endodontically treated teeth that could generate artifacts compromising image quality; Pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-2g9vbx	Comparison of toothpaste containing fluoride associated or not with arginine in initial caries lesions in milk teeth	Recruiting	Intervention	2017-11-07	<NULL>	<NULL>	4487	Comparison of the remineralization potential of the dentifrice containing 1,450 ppm sodium monofluorophosphate associated or not with 1.5% arginine in white spot lesions in primary teeth: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Cruzeiro do Sul	Universidade Cruzeiro do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2g9vbx	<NULL>	Healthy children; aged 4 and 5 years old; both genders; resident in the city of São Paulo  (public water fluoridation); present at least one visible active white spot lesion on smooth surface of maxillary anterior primary teeth (ICDAS  2); present signed Parent-Guardian Informed Consent Statement	Children who participated of previous research over the past 3 months; using orthodontic devices; with cognitive impairment or syndromes; using medication; receiving dental treatment with professional topical fluoride application (varnish, gel or mousse); children who not allow clinical examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-3y357v	Comparison of tracheal tubes for children&apos;s tracheas intubation	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1027	Comparison of the use of uncuffed tracheal tube versus cuffed tracheal tubes filled with saline solution, lidocaine or air in pediatric patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-03	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3y357v	<NULL>	Children undergoing general anesthesia; aged between 3 and 13 years; both genders; physical status 1 or 2 according to American Society of Anesthesiologists; minor or medium level surgery	Oropharyngeal and neck malformations and distortions; patients who had already been intubated or tracheostomised; previous presence of stridor or dysphonia; laryngeal or oropharyngeal illness or surgery; requirement for the introduction of a nasogastric or orogastric tube; more than two attempts at tracheal intubation; use of corticosteroids during the perioperative period; the use of local anaesthetic agents administered through a route other than that used to fill the tracheal tube cuffs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-9x4s6y	Comparison of tracheal tubes for tracheal intubation in children undergoing surgery for tonsils removal	Recruitment completed	Intervention	2016-11-18	<NULL>	<NULL>	1071	Comparison of tracheal tube cuffs filled with Air or Alkalinized Lidocaine in patients undergoing Tonsillectomy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9x4s6y	<NULL>	Children undergoing tonsillectomy or adenoidectomy under general anesthesia; aged between 4 and 12 years; both genders; physical status ASA I or II according to American Society of Anesthesiologists	Oropharyngeal and neck malformations and distortions; patients who had already been intubated or tracheostomized for the surgery; the previous presence of stridor or dysphonia; prolonged tracheal intubation required after surgery; laryngeal or oropharyngeal illness or surgery; requirement for the introduction of a nasogastric or orogastric tube; more than two attempts of tracheal intubation; infection at the surgical site verified during pre-anesthetic evaluation; need of intensive care unit after surgery (severe sleep apnea)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-83fs5dr	Comparison of Treatment Duration (12 or 24 hours) for Patients with Postpartum Pre-Eclampsia: a Randomized Clinical Study	Not yet recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7196	Comparison of Magnesium Sulfate regimen for 12 or 24 hours in Postpartum Women with Pre-Eclampsia: A Randomized Clinical Study	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-83fs5dr	<NULL>	Pregnant patients, diagnosed with pre-eclampsia, with indication for the use of magnesium sulfate due to maternal cause, as assessed by the care team; start using magnesium sulfate before delivery, with a schedule for maintaining the medication after delivery	"Patient unable to understand the informed consent form, due to cognitive incapacity, definitive or temporary, as a result of pre-eclampsia itself (suspected bleeding in the central nervous system) or due to a cause prior to pregnancy. Patients unable to read the informed consent form (because they are intubated or have clinical or imaging evidence of neurological involvement) will not be invited to participate in this study, as they are considered to be in a vulnerable situation that prevents their participation in this protocol; gestational age is less than 24 weeks;
diagnosis of fetal death before delivery (i.e., ultrasound diagnosis of absence of fetal heartbeat upon admission for delivery); presence of multiple pregnancy (more than one fetus); patient with antenatal diagnosis of fetal malformation incompatible with extrauterine life; indication for the use of magnesium sulfate was made exclusively for fetal neuroprotection due to the risk of premature birth, without any maternal clinical indication that would justify its use; magnesium sulfate treatment was suspended before delivery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-7zhgb3	Comparison of treatment of platelet-rich plasma non-healing wounds in patients with venous abnormalities	Data analysis completed	Intervention	2019-12-17	<NULL>	<NULL>	3294	Comparison of the treatment of chronic ulcers with platelet rich plasma in patients with venous insufficiency	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7zhgb3	<NULL>	Diagnosis of chronic venous insufficiency; at most 80 years old and minimum of 18 years; ulcer with diameter 10 to 40 cm²	Exclusion criteria will be: base diseases of influence on healing, patients with malignant neoplasia in the last five years, lupus, carriers of ulcers neuropathic or arterial diseases, or any other type of ulcer in the lower limbs that is not related to chronic venous insufficiency; the patients who presented 3 (three) consecutive absences or 6 (six) alternate and the non-consent to participate in the research willingly and spontaneously, Uncontrolled Systemic Arterial Hypertension (SAH), Acquired Immunodeficiency Syndrome (HIV), Anemia, Stroke or Acute Myocardial Infarction (AMI) in the last 3 months, Renal insufficiency (creatinine more than 2 mg / dl), Liver Disease (TGO more than 2x upper limit, INR more than 1.5), surgery or major trauma in the last 2 months, pregnant woman, mental retardation, inclusion in other studies in the last 30 days and relative of first or second degree of another patient in the study group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-10m379hg	Comparison of trunk and leg muscle activities in hippotherapy and walking in healthy individuals	Data analysis completed	Intervention	2020-12-23	<NULL>	<NULL>	4438	Electromyographic analysis of muscle activation of the trunk and lower limbs in hippotherapy compared to the gait of healthy individuals	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Triângulo Mineiro	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-10m379hg	<NULL>	independent walking; both genders; age between 19 and 24 years old; the signature of the term of responsibility for the practice of hippotherapy; signed free and informed consent term; sedentary lifestyle; assessed using the IPAQ; irregular activity Was defined as a physical activity performed at a frequency of up to 5 days/week or a maximum duration of 150min/week; although sedentary; all the participants were healthy and in good general condition.	Abandonment;  absence on the day of collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:12
RBR-36bxjx	Comparison of two anesthetic gels at maxillary posterior teeth extraction.	Recruitment completed	Intervention	2016-12-05	<NULL>	<NULL>	3731	Comparison of anesthetic efficacy between two gels in extraction of upper molars : a randomized clinical trial.	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2015-11-25	Universidade Federal de Sergipe	Faculdade de Odontologia de Piracicaba- Universidade de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-36bxjx	<NULL>	Individuals treated at the Department of Dentistry, Federal University of Sergipe ; of both genders; in the age range 18-60 Years of Age; sign an Informed Consent Form; Need of bilateral upper molars extraction	History of allergy or other problems arising from the use of any components of the formulations to be employed; History of methemoglobinemia; Alcoholics and toxic users; Fear of dentist; Pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-3tb25z8	Comparison of two bone reconstruction techniques in dental implant treatment: Barbell and Titanium-Reinforced Polytetrafluoroethylene Membranes	Not yet recruiting	Intervention	2025-11-29	<NULL>	<NULL>	8598	Barbell Technique versus Titanium-Reinforced PTFE Membranes in Guided Bone Regeneration: a prospective randomized clinical study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Instituto de Ciência e Tecnologia - Campus de São José dos Campos - Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Loss of three adjacent teeth in an atrophic alveolar ridge in the maxilla or mandible, according to the horizontal alveolar changes classification; need for bidirectional horizontal bone augmentation; residual bone height (minimum of 8 mm) at the surgical site; adequate oral hygiene; presence of 2 mm of keratinized tissue in the attached gingiva; aged between 18 and 75 years; both genders	Periodontal or peri-implant diseases; contraindications to surgical procedures; dental implants adjacent to the surgical site; smokers; diabetic patients; history of previous radiotherapy or chemotherapy; use of immunosuppressants, bisphosphonates, or corticosteroid therapy; pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3fbjdh7	Comparison of two clear aligner protocols for correcting Class II malocclusion	Recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9183	Comparison of two treatment protocols for Class II malocclusion with clear aligners in patients with permanent dentition: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-05	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients of both sexes, aged between 14 and 25 years, presenting with a full permanent dentition up to the second molars; Class II, Division 1 malocclusion, with severity ranging from ¼ to ¾ based on the molar relationship	Class II, Division 2 malocclusion, or Class II malocclusions with severities greater than ¾ according to the molar relationship;Patients who have previously undergone orthodontic treatments involving premolar extractions; Patients with any systemic condition that may affect periodontal health, as well as those with facial deformities or syndromes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-9c2my6	Comparison of two components in phenol peels	Recruitment completed	Intervention	2019-09-17	<NULL>	<NULL>	2961	Randomized controlled trial comparing the Efficacy of two components in the Phenol-croton oil formula	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Hospital Heliópolis	Hospital Heliópolis	https://ensaiosclinicos.gov.br/rg/RBR-9c2my6	<NULL>	phototypes between I and III according to Fitzpatrick&apos;s; photoaging according to Global Photoaging Score Types III and IV; non smoking	"Recent history of skin lesions or surgeries in the past three months; Medical history of heart disease and/or arrhythmias of any nature, kidney failure or hepatic disease; Medical history of Asthma or Chronic Obstructive Pulmonary Disease (COPD); Medical history of Iron Overload (Hemochromatosis); Use of oral Isotretinoin (13-cis-retinoic acid) in the past six months; Patients with immunosuppressive Conditions, Decompensated Diabetes or Systemic Conditions which interfere on the healing/scaring process such as Malnutrition and Neoplasms; Personal history of keloid.
Smoking.
Collagenose.
Pregnancy or Breastfeeding"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-268ms5y	Comparison of two different minimally invasive surgical techniques in primary open angle glaucoma	Recruiting	Intervention	2023-07-29	<NULL>	<NULL>	6952	Comparison of Bent ab interno needle goniotomy (BANG) and Gonioscopy-assisted transluminal trabeculotomy (GATT) in primary open angle glaucoma: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-268ms5y	<NULL>	Primary open angle glaucoma, defined by an open angle on gonioscopy evaluation, visual field loss and RNFL damage on OCT; age between 18 and 80 years; visual field mean deviation (MD) &gt; -12dB; RNFLT&gt;60μm on OCT; prior phacoemulsification with IOL implant; best corrected visual acuity  ≥0,1 on Snellen chart; IOP≥18mmHg with 3 IOP-lowering drops, and between 20mmHg and 36mmHg after medication wash-out	Other types of open angle glaucoma: steroid-induced, pseudoexfoliation, pigmentary e juvenile; congenital glaucoma; angle-clousure; prior cataract surgery less than 30 days; drainage device implant or cyclophotocoagulation; prior vitreoretinal surgery; cornea opacity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-55mp5z	Comparison of two drugs to prevent nausea and vomiting after surgery for reducing the stomach	Recruiting	Intervention	2016-03-18	<NULL>	<NULL>	762	Palonosetron versus ondansetron for postoperative nausea and vomiting prophylaxis in laparoscopic gastroplasty in morbid obese patients - a randomized controlled noninferiority trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-11-15	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-55mp5z	<NULL>	Adult patients undergoing elective laparoscopic gastroplasty; both sexes; 20 to 65 years old; physical state I and II according to American Society of Anesthesiology (ASA); body mass index equal or higher than 35 kg/m2	Use of antiemetics for 48 hs before surgery; those with hiatal hernia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-4mjv6r	Comparison of two drugs to prevent nausea and vomiting after surgery for removing the gallbladder	Recruiting	Intervention	2017-04-12	<NULL>	<NULL>	4427	Palonosetron versus Ondansetron for Postoperative Nausea and Vomiting Prophylaxis in Laparoscopic Cholecystectomy. A Randomized Controlled Noninferiority Trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-01-02	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4mjv6r	<NULL>	Adult patients undergoing elective laparoscopic cholecystectomy; both genders; 18 to 65 years old; physical status I and II according to American Society of Anesthesiology (ASA)	Use of antiemetic drugs for 48 hours before surgery; those with hiatal hernia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:11
RBR-785ghf	Comparison of two medium for semen freezing with addition of some components in order to improve the quality of spermatozoa of infertile men.	Recruiting	Intervention	2018-02-14	<NULL>	<NULL>	1641	Comparison of two medium for semen cryopreservation regarding the effects of lipid supplementation and antioxidant action on sperm viability in men with altered seminal parameters: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Medicina de Ribeirão Preto	Invitra	https://ensaiosclinicos.gov.br/rg/RBR-785ghf	<NULL>	Men aged 18-40 years; literate;sent to the accomplishment of the spermogram in the laboratory of Gynecology and Obstetrics; able to collect the semen by masturbation; accept to participate in the study by signing a Term of Free and Informed Consent	Semen volume smaller than or equal 1.5 ml; sperm concentration greater than 15 million / mL; progressive motility greater than 32%; azoospermia; history of cancer from any location; previous or current use of chemotherapeutics or other medications known to interfere with spermatogenesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-10gcc5f8	Comparison of two membrane types for bone regeneration around immediate dental implants	Not yet recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9072	Evaluation of a bovine pericardium collagen membrane in guided bone regeneration around immediate implants: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-15	Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Inclusion criteria comprise participants aged over 18 years classified as ASA I or ASA II according to the American Society of Anesthesiologists presenting teeth indicated for extraction in the aesthetic zone of the maxilla involving central incisor or lateral incisor or canine or first premolar or second premolar being a single unit. Participants must present transverse root position Class I or Class II or Class III according to Kan and Class I socket with intact buccal wall or Class II socket with up to one third of the buccal wall compromised in addition to buccal recessions of up to 2.0 millimeters and sufficient bone thickness and height for immediate implant placement with primary stability possessing natural teeth adjacent to the element to be extracted.	Patients classified above ASA II or heavy smokers defined as those consuming over 10 cigarettes per day or with a history of radiotherapy in the head and neck region or undergoing chemotherapy for treatment of malignant tumors or patients with uncontrolled diabetes defined as glycated hemoglobin above 7.0 millimoles per liter will be excluded. Also constituting exclusion criteria are the presence of pathological soft tissue alterations in the intervention region such as leukoplakia or lichen planus or erythroplakia and extensive periapical bone pathological alterations that prevent implant placement as well as localized periodontitis in the intervention region or Stage IV Periodontal Disease without occlusal stability or Class IV sockets according to Kan.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-9krffvx	Comparison of Two Methods for Securing Subcutaneous Access and Their Effects on Comfort and Safety of Patients in Palliative Care	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7660	Effects of two Hypodermoclisis fixation techiniques on the occurrence of adverse event, length of stay and their implications for patient comfort in palliative care: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-9krffvx	<NULL>	patients of both sexes; from 18 years of age; with a medical prescription for hypodermoclysis; who do not have a diagnosis of skin changes; who do not have a known history of allergy to the tape used	Patients who develop an allergy to the tape used; are transferred to another unit will be discontinued from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-494r9r	Comparison of two methods of complete denture fabrication	Recruiting	Intervention	2016-11-18	<NULL>	<NULL>	1070	Traditional versus simplified method for complete denture fabrication in edentulous patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-494r9r	<NULL>	Complete Edentulism (mandible or maxilla) for at least one year; Receptive and mentally agile; Availability to attend evaluations during the study period.	Uncontrolled systemic diseases; Temporomandibular disorders; Surgical Procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-5t6m6jh	Comparison of two pain control techniques after minimally invasive kidney removal surgery	Not yet recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8890	Comparison of postoperative analgesia between Quadratus Lumborum Block and Intrathecal Morphine in patients undergoing Minimally Invasive Nephrectomy: a prospective randomized study	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-15	AC Camargo Cancer Center	<NULL>	<NULL>	<NULL>	Adult patients classified as American Society of Anesthesiologists (ASA) physical status I–III undergoing elective laparoscopic partial nephrectomy at the AC Camargo Cancer Center hospital complex	Obese patients (Body Mass Index &gt; 30); patients with ASA physical status &gt; III; those with contraindications to spinal anesthesia or quadratus lumborum block; patients with cognitive impairment precluding reliable assessment using the visual analog scale for pain; patients who develop severe clinical or surgical complications; patients with allergy to morphine or ropivacaine; and patients who refuse to provide written informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-10y59z79	Comparison of two settings of the same Laser in the endoscopic treatment of Kidney Stones	Recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8748	Comparison of the efficacy of two energy and frequency settings of the Pulsed Thulium:YAG Laser in the treatment of Renal Calculi by Transureteroscopic Ureterorenolithotripsy: a prospective randomized study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFM/USP)	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; both sexes; renal calculi with volume between 1600 and 4000 mm³; candidates for lithotripsy by retrograde ureterorenolithotripsy; provision of written informed consent	Impossibility of performing retrograde ureteroscopy (e.g., prior urinary tract reconstruction); inability to introduce a ureteral access sheath; contraindications to surgery, such as untreated urinary tract infection; concomitant ureteral stone; uncontrolled comorbidities; refusal to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-7zygtt6	Comparison of two strategies to adjust blood pressure medication in patients with severe infection and shock	Not yet recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8698	Strategy of norepinephrine titration guided by peripheral perfusion versus conventional strategy guided by arterial pressure in patients with septic shock	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Fundação Universidade Caxias do Sul Hospital Geral	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; suspected or confirmed septic shock according to the Third International Consensus Definitions for Sepsis and Septic Shock; requirement for vasopressor therapy to maintain a mean arterial pressure of 65 millimeters of mercury or higher after adequate fluid resuscitation; serum lactate level of 2 millimoles per liter or higher; initiation of norepinephrine within the previous 12 hours; admission to the intensive care unit of Hospital Geral de Caxias do Sul; written informed consent provided by the participant or legal representative	Limitation of life sustaining treatment or do not resuscitate order; chronic dialysis or indication for renal replacement therapy within the next 8 hours; age younger than 18 years; hypotension not related to sepsis; traumatic brain injury; recent stroke; scleroderma; sickle cell disease; significant arrhythmias; pregnancy; refusal to participate in the study; severe peripheral vascular disease; hemorrhagic shock; cardiogenic shock; obstructive shock	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-2tyjxf2	Comparison of two surgical techniques for treating recent achilles tendon injuries: a clinical study	Not yet recruiting	Intervention	2024-12-14	<NULL>	<NULL>	7590	Comparison of two Surgical techniques of Acute Injury Repair in the Achilles Tendon: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-02	Instituto de Ciências da Saúde da Universidade Federal do Pará - ICS/ UFPA	Hospital Maradei	https://ensaiosclinicos.gov.br/rg/RBR-2tyjxf2	<NULL>	18 to 60 years old; both sexes; closed Achilles tendon injury with up to 21 days of evolution; non insertional Achilles tendon injury	Bilateral injury; history of previous surgery on the lower limb with injury; rerupture; diabetes mellitus; neurovascular disease; immunosuppressive therapy; use of drug from the fluoroquinolone group; patient who does not attend the return appointment; patient who does not follow the rehabilitation protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-9z8my4	Comparison of two surgical techniques of fissure filling with synthetic bone in patients with cleft lip	Recruitment completed	Intervention	2016-07-11	<NULL>	<NULL>	914	Comparison of two techniques of surgical access for alveolar bone grafting in patients with cleft lip and palate	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-18	Coordenação de aperfeiçoamento de pessoal de nível superior	Hospital de reabilitação de anomalias craniofaciais	https://ensaiosclinicos.gov.br/rg/RBR-9z8my4	<NULL>	Age between 9 and 20 years; Indication for secondary or tertiary unilateral alveolar bone graft; Satisfactory oral hygiene; Absence of periodontal disease and probing depth 3 mm or less in the examined sites; Absence of bone resorption and; Amount of keratinized tissue in the anterior maxilla of at least 2 mm (Lang and Löe 1972).	Smokers; Anticonvulsant, anticoagulants or anti-inflammatory drugs; Systemic diseases and craniofacial syndromes; Presence of prosthetic reconstruction in anterior and upper teeth; Absence of teeth adjacent to the alveolar cleft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-7sgsn5	Comparison of two techniques of separation of the Lingual Frenulum	Not yet recruiting	Intervention	2019-11-01	<NULL>	<NULL>	3164	Comparative analysis between two Lingual Frenotomy surgical techniques	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	Universidade do Extremo Sul Catarinense (UNESC)	Universidade do Extremo Sul Catarinense (UNESC)	https://ensaiosclinicos.gov.br/rg/RBR-7sgsn5	<NULL>	Infants who have ankyloglossia and will be submitted to lingual frenotomy. In the Criciúma macroregion.	Infants aged six months or more; presence of other congenital malformations; prematurity; genetic syndromes; and mild ankyloglossia. Conditions that make it impossible to perform surgery; or the refusal of those responsible for the research participation. Patients with relapsed ankyloglossia. No signature of the TCLE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-487ctp	Comparison of two treatment options for patients with precursor lesions of skin cancer: colchicine cream versus 5-FU cream	Not yet recruiting	Intervention	2020-03-03	<NULL>	<NULL>	3555	Clinical and dermatoscopic evaluation of the effectiveness of Colchicine 0,5% cream versus 5-Fluorouracil 5% cream in the treatment of Actinic Keratosis and Cutaneous Cancerization Field: a randomized clinical trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-03-17	Instituto Lauro de Souza Lima (ILSL)	Faculdade de Medicina da Universidade Estadual Paulista (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-487ctp	<NULL>	Sign the Informed Consent Form; age over 18 years, both sexes; present a minimum of 3 and a maximum of 10 lesions clinically compatible with AK on each dorsal face of the forearm.	Exclusion criteria: treatment area that has an atypical clinical appearance, suggestive of carcinoma, or other extensive dermatoses; current and / or previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances under study; patients using any systemic or topical immunosuppressive substance, oral retinoid, in addition to other local treatments (eg: corticosteroids, anti-inflammatories, topical retinoids); patients who have received any type of treatment for skin field cancerization less than 6 months before the start of the study; immunocompromised individuals; coagulation disorders; suspected or confirmed pregnancy; women of childbearing potential who do not use contraception; women who are breastfeeding. Discontinuation criteria: withdrawal of consent; presence of infection (erysipelas, cellulitis or abscess) during follow-up in the treatment areas; loss of follow-up; use of other AK treatment methods other than the one proposed; serious adverse event, at the investigator&apos;s discretion; pregnancy during follow-up; failure to take photographic images of the lesions on the days determined before the start of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-6dh6cm	Comparison of two treatments of wounds in the nipples of breastfeeding women	Recruitment completed	Intervention	2012-10-25	<NULL>	<NULL>	1707	Clinical trial for the management of nipple trauma on breastfeeding	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-16	Faculdade de Enfermagem da Universidade Federal de Goiás	GESMAC - Grupo de Estudo em Saúde da Mulher, do Adolescente e da Criança	https://ensaiosclinicos.gov.br/rg/RBR-6dh6cm	<NULL>	Woman in exclusive breastfeeding; have old 18 years or more; having given birth to infants who are able to be breastfed; have a telephone for contact; presenting clinical evidence of detectable macroscopically unilateral or bilateral nipple trauma in the period up to day 10 postpartum.	Health problems that interfere with the healing process; anatomical changes that favor the nipples nipple trauma (inverted nipple, inverted nipple pseudo); residence outside the city of Goiania - GO.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-8wt2fy	Comparison of Two Types of General Anesthesia, Venous versus Inhalatory, regarding the Risk of Renal Injury after Videolaparoscopic Obesity Surgery	Data analysis completed	Intervention	2014-08-13	<NULL>	<NULL>	325	Efficacy of Total Intravenous Anesthesia (TIVA) in blocking Perioperative Elevation of NGAL in Laparoscopic Bariatric Surgery	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2010-10-01	Adriano Teixeira Fernandes	Norma Sueli Pinheiro Módolo	https://ensaiosclinicos.gov.br/rg/RBR-8wt2fy	<NULL>	morbidly obese patients, scheduled for video laparoscopic bariatric surgery; both gender; age between 18 and 65 year.	volunteers with lung disease; heart failure; renal failure; cancer of any etiology; patients on chronic corticosteroid use; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-8k2vpx	Comparison of two types of procedures used to prevent venous thrombosis after total knee prosthesis surgery: with medication or mechanical device	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	5193	Comparison of the effect of the type of Thromboprophylaxis (Mechanical or Pharmacological) on blood loss and postoperative edema in total knee arthroplasty	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-05	Hospital Maradei	Faculdade de Medicina da Universidade de São Paulo (FMUSP)	https://ensaiosclinicos.gov.br/rg/RBR-8k2vpx	<NULL>	Adult patients submitted to total knee arthroplasty	Personal history of venous thromboembolism (deep vein thrombosis or pulmonary embolism); coagulation disorders; peptic ulcer disease; liver disease; enoxaparin allergy; malignant tumors;  patients undergoing any surgery in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-7rw2qq	Comparison of two types of protocols for the construction of dentures	Data analysis completed	Intervention	2017-06-09	<NULL>	<NULL>	1252	Comparison of different methods for making conventional complete dentures	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Odontologia da Universidade Federal de Goias	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7rw2qq	<NULL>	Fully edentulous, with need of new upper and lower conventional complete dentures	"Patients unable to cooperate;
Patients in poor general health or conditions that could influence their response to treatment such as temporomandibular disorders, orofacial motor disorders, severe oral manifestations of systematic disease or psychological or psychiatric condition"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-75scwh	Comparison of Two Types of Training in Physical and Organic Performance	Data analysis completed	Intervention	2013-07-08	<NULL>	<NULL>	239	Effects of Concentric vs Eccentric Resistance Training in Clinical, Functional, Cardiovascular and Biological Parameters	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-09-20	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-75scwh	<NULL>	Adults with age between 18 and 30 years old, be male, self declared healthy and no medical restriction for physical activity, classified as physically active by IPAQ (International Physical Activity Questionnaire)	Subjects with cardiovascular, respiratory and/or metabolic disorders, alcoholic, smokers, injury episode osteoarticular or muscle-tendon in the lower limbs and/or column in the last year and did participate in weight-training program for at least 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-7ggfkv	Comparison of two ways of using tapings in patients with back pain.	Data analysis completed	Intervention	2012-01-17	<NULL>	<NULL>	208	Comparison of two techniques for using the Kinesio Taping in patients with chronic non-specific low back pain: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Universidade Cidade de São Paulo	Equipe Ricardo Takahashi	https://ensaiosclinicos.gov.br/rg/RBR-7ggfkv	<NULL>	Chronic low back pain in patients that were seeking care; patients with chronic low back pain from the community;  Patients with a pain intensity level of at least 3 points on a 0-10 Pain Numerical Rating Scale.	Patients with any contra-indication for the interventions (i.e. lumbar stenosis, spinal fractures, cancer, acute infections, lumbar osteoporosis, acute rheumatic conditions, any bleeding diseases, spinal tuberculosis, and deep venous trombosis, allergy or intolerance to the material).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-9n3dqnn	Comparison of Vitamin D Supplements in Obese and Healthy Women	Recruiting	Intervention	2026-04-29	<NULL>	<NULL>	9150	Comparison of the effects of supplementation with calcifediol, cholecalciferol, or placebo on plasma vitamin D metabolites and biomarkers of bone metabolism in obese and normal-weight women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women with obesity (BMI greater than or equal to 30 kg/m²), aged 18 to 60 years, followed at the Obesity Outpatient Clinic. Control group: women with BMI between 18.5 and 24.9 kg/m², aged 18 to 60 years	Age under 18 years; pregnancy or lactation; intestinal malabsorptive disorders; use of medications that interfere with vitamin D metabolism or absorption (corticosteroids, anticonvulsants, isoniazid, antiretrovirals, antifungals, orlistat, cholestyramine); primary/tertiary hyperparathyroidism; hypoparathyroidism; osteoporosis; osteomalacia; rickets; thyrotoxicosis; chronic kidney disease (creatinine clearance under 45 mL/min); history of cancer; chronic liver failure; patient refusal. Use of any commercial vitamin D formulations within the past 2 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-5zrzg4	Comparison of water exercises for children with cerebral palsy to improve their walking	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3738	Comparison of aquatic intervention protocols and its repercussion in the gait of children with cerebral palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-02	Associação de Assistência a Criança Deficiente	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5zrzg4	<NULL>	Children with spastic diparesis type of Cerebral Palsy;classified as level II and III on GMFCS; with age between 6 years and 8 years and 11 months will be included.	It will be excluded children that does not cooperate; unable to understand the proposed activities;submitted to orthopedic surgeries at less than 12 months; and peripheral blocks for less than 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-98myd6	Comparison study between chamomile and calendula creams to prevent radiation-induced skin lesions	Recruiting	Intervention	2020-04-03	<NULL>	<NULL>	3701	Comparative study of chamomile and calendula creams in the prevention of radiodermatitis: double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-27	Daniele Machado Oliveira Andrade	Daniele Machado Oliveira Andrade	https://ensaiosclinicos.gov.br/rg/RBR-98myd6	<NULL>	Both sexes; age equal to or over 18 years; diagnosis of head and neck cancer	History of radiotherapy in the same field of treatment; previous report of allergic reaction to chamomile or calendula	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-427g9ht	Comparison study of the different Surgical Techniques for the treatment of Benign prostatic growth with large volume: Endoscopic Laser Treatment x Minimally-invasive Abdominal Treatment x Endoscopic Treatment with Bipolar Energy	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6542	Randomized clinical trial evaluating the Surgical Treatment of large-volume Benign Prostatic Hyperplasia: Endoscopic Enucleation with Holmium Laser x Minimally-invasive Simple Prostatectomy x Bipolar Transurethral Resection of Prostate	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-30	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-427g9ht	<NULL>	Prostatic volume between 80 and 150mL measured by abdominal ultrasound of the prostate. Present at least one indication criteria for surgical treatment of Benign prostatic hyperplasia (BPH): renal failure with bilateral ureterohydronephrosis, recurrent macroscopic hematúria, acute urinary retention, recurrent urinary tract infection secondary to high post-void volume, moderate to severe voiding urinary symptoms even with clinical treatment interpreted by International Prostate Symptom Score (IPSS) &gt; 15 and/or maximum urinary flow (Qmax) &lt; 12mL/s,  moderate to severe voiding urinary symptoms interpreted by International Prostate Symptom Score (IPSS) &gt; 15 and/or maximum urinary flow (Qmax) &lt; 12mL/s in patients intolerant to pharmacological therapy	Prostate câncer. Neurogenic bladder. Previous prostatic surgeries. Bladder stones. Urethral pathologies. Impossibility of suspending anticoagulants or anti-platelet agentes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-2m67zd	Comparison the effect of HDx therapy and high flux hemodialysis on endothelium function in hemodialysis patients	Recruiting	Intervention	2018-06-28	<NULL>	<NULL>	1940	A randomized, open-label, crossover, clinical trial to compare the effect of HDx therapy versus high flux hemodialysis on endothelium function in hemodialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação Oswaldo Ramos - Hrim	Fundação Oswaldo Ramos - Hrim	https://ensaiosclinicos.gov.br/rg/RBR-2m67zd	<NULL>	"Male and female aged 18 years old;in hemodialysis program for at least 6 months before the enrollment; with adequate vascular access; hemodialysis 4 hours 3 times/week;
with a result of KtV 1.2 in the 3 months prior to the study and signed the ICF."	Patients with Heart failure III or IV NY class; peripheral arterial disease, previous stroke within the last 3 months before the enrollment; active inflammation or infection disease within the last 3 months before the enrollment; pregnant or lactating female.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-6zc4cb	Comparitive study between Carnoy and GEWF solutions for identifying lymph nodes in patients with cancer of the large bowel	Recruiting	Intervention	2016-04-25	<NULL>	<NULL>	806	Randomized clinical trial comparing Carnoy&apos;s and GEWF solutions for Lymph Node Clearing Technique in Colorectal Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Hospital Moinhos de Vento	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6zc4cb	<NULL>	Patients with histologically proven adenocarcinoma of the colon or rectum; both sexes; over 18 years of age; underwent surgical treatment performed by colorectal surgeons; agreement of the attending physician and the patient to participate in the study ;	Inaccuracy or unavailability of patient´s data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-10x3sdwq	Compassion Focused Therapy for People with Obesity	Recruiting	Intervention	2021-02-08	<NULL>	<NULL>	4518	Compassion Focused Therapy for People with Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10x3sdwq	<NULL>	Samples of people aged between 18 and 50 years, of both sexes, with complete elementary education and with obesity grade 1 (BMI between 30.0 - 34.9 kg / m2) or obesity grade 2 (BMI between 35, 0 - 39.9 kg / m2), characterized as an agreement with the World Health Organization (WHO, 2010), which presents emotional nutrition, compulsion and body dissatisfaction.	The sample will exclude people with psychotic disorders, autism, severe suicidal ideation, depression, anxiety or other mental disorders in an acute state, assessed by the DASS-21 instrument and by the DSM-5-based Clinical Interview (First et al., 2017)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-3w744z	Compassion Meditation vs. Social Vulnerability: Effects on Individual and Collective Well-Being	Recruitment completed	Intervention	2019-04-22	<NULL>	<NULL>	2622	Cognitively-Based Compassion Training - CBCT  vs. Social Vulnerability: Effects on Individual and Collective Well-Being	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-17	Universidade Federal de São Paulo	Escola Paulista de Enfermagem UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-3w744z	<NULL>	Healthy volunteers; both sexes; aged between 18 and 75 years; the region for at least a year; participating in some action linked to the Center of Excellence in Early Childhood for at least 3 months	Subjects diagnosed with some mental illness and in treatment of mental illness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-4pgd3ct	Complementary therapies for Depression	Recruiting	Intervention	2023-10-19	<NULL>	<NULL>	6523	Complementary therapies in the treatment of Major Depressive Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4pgd3ct	<NULL>	Current depressive episode; Age between 18 and 40 years old; Study/ work in UFRN; Have internet connection to allow the usage of the app on the smartphone or computer website.	Diagnosis for mental illnesses other than major depressive disorder; Prescription of any medicine with psychiatric, neurological, neurovegetative, cognitive or mood effect other than antidepressants; Have any phobic symptom against injection, blood or wound; Pregnancy and lactation; Any physical or mental disability that make impossible the execution of the complementary therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-42c8wp	Complementary Therapies for stress and anxiety reduction and improving quality of life	Recruiting	Intervention	2016-03-18	<NULL>	<NULL>	761	"Applicability of Complementary Therapies for pain, stress, anxiety reduction
and improving quality of life: Randomized Clinical Trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-30	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-42c8wp	<NULL>	Inclusion Criteria: The patients with  medium and high level of stress score on the Stress Symptoms List (LSS)	Exclusion Criteria: pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressant or other energy therapies to manage stress and anxiety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-28s4hz	Complementary Therapies to reduce stress  and anxiety and to improve quality of life	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	663	Applicability of Complementary Therapies to reduce pain, stress, anxiety and improving quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-30	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-28s4hz	<NULL>	"•	Inclusion Criteria: The patients who are treated by the ITIO Reiki Clinic between June and September of 2015 will be invited and 90 people will be randomized (80% power and 95% confidence interval), which have middle and  high level of stress score on the Stress Symptoms List (LSS)"	"•	Exclusion Criteria: pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressants or other energy therapies to manage stress and anxiety. Those who are receiving psychological therapy, however, won’t be excluded and will be oriented to continue such treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-7p2xmg	Complete Denture Retained by One Short Implant in resorbed jaws: a prospective study	Recruitment completed	Intervention	2020-08-13	<NULL>	<NULL>	4121	Overdenture retained by a Single Short Implant in atrophic mandibles: a prospective study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Odontologia da Universidade Federal de Goias	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7p2xmg	<NULL>	Present the need to replace or to receive new dentures according to normative criteria and/or own demand (perceived need); Do not have contraindications to the surgical procedure of implant installation (mainly related to uncontrolled systemic diseases, such as diabetes and hypertension); To present reduced bone volume in the mandibular symphysis with a maximum height of 9 mm (base of the chin to the alveolar ridge) for the installation of a short implant without the need for bone grafting procedures; Be able to understand and respond to the questionnaires used in the study.	Unavailability to meet the schedule of return visits; Local conditions that could directly influence the stability and/or retention of the prostheses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-293yfsj	Complete Dentures Obtained by Three-Dimensional Printing Compared to the Conventional Technique – Clinical, Crossover, Randomized and Controlled Study	Recruiting	Intervention	2025-06-16	<NULL>	<NULL>	8055	Complete Dentures obtained by Additive Manufacturing compared to Conventional Manufacturing – Clinical crossover, randomized and controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-19	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-293yfsj	<NULL>	Individuals aged 45 years or older; of both genders; completely edentulous for at least 1 year; mentally receptive; with good understanding of spoken Portuguese; with normal unstimulated saliva flow (0.3 mL/min); without Denture-Related Stomatitis; presenting satisfactory or good ridges, according to the Kapur Index	Individuals with disorders of the stomatognathic system; with pathological alterations of the ridges or seat tissues of the prostheses; debilitating systemic conditions such as Decompensated Diabetes Mellitus, Chronic Kidney Disease, Chronic Obstructive Pulmonary Disease, Heart Failure, Advanced Liver Disease and malignant tumors; autoimmune diseases such as Systemic Lupus Erythematosus or Multiple Sclerosis; HIV/AIDS and malnutrition; self-reported pain; motor and cognitive disorders; use of antibiotics in the 3 weeks prior to recruitment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-33hrzwh	Complications of exodontia	Recruiting	Observational	2023-09-26	<NULL>	<NULL>	6461	Discomforts and complications associated with dental extraction surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-33hrzwh	<NULL>	Dental extractions as part of routine dental procedures, with precise indication for their execution. Urgeries of non-impacted or included third molars with short and convergent roots. Consent to participate in the research and sign the informed consent form.	Pediatric patients with surgeries indicated for deciduous teeth. Surgeries of included third molars or with any degree of bone impaction. Patients under 18 years of age with an indication for dental extraction, without the presence and consent of a legal guardian.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-5cgb4g	Comportamento do P300 em pacientes usuários de implante coclear com eletroestimulação unilateral	Recruitment completed	Intervention	2017-12-01	<NULL>	<NULL>	1508	Long Latency Auditory Evoked Potentials (P300) outcomes in  patients with unilateral cochlear implants	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto- Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto- Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5cgb4g	<NULL>	Patients with post-lingual hearing loss undergoing cochlear implant surgery	prelingual hearing loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-4rtyfm	Composite resins restorations in posterior teeth using in association with two materials: bulk-fill resin or glass ionomer cement.	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1385	Class II restorations evaluation using bulk-fill resin base or glass ionomer cement: Clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4rtyfm	<NULL>	older than 18 years; both genders; needed for Class II restorations due to the presence of carious lesions and / or due to replacement of preexisting restorations with caries recurrence, loss or fracture of restorations; presence of at least three vital dental elements to be restored by each participant whose opposing teeth are present; good general health; acceptable level of oral hygiene; presence of at least 20 teeth under occlusion.	high risk of caries and / or periodontal disease; holders of removable or orthodontic appliances; patients with bruxism and / or xerostomia; cavities which, after preparation, do not have a minimum depth of 4 mm in the proximal box; pregnant or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-65ntbc	Composite Restoration in Permanent Teeth after Selective Removal of Caries	Recruitment completed	Intervention	2018-04-10	<NULL>	<NULL>	1701	Restorative Adhesive Treatment  in Permanent Teeth after Selective Removal of Caries Tissue - A Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-05	Universidade Federal do Rio Grande do Sul - UFRGS	Universidade Federal do Rio Grande do Sul - UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-65ntbc	<NULL>	Patients with absence of uncompensated systemic diseases affecting their caries experience with permanent molars and premolar with deep carious lesions involving the inner half of dentin (Radiographic examination); pulp sensitivity diagnosed by thermal test using refrigerated gas; absence of spontaneous pain history; absence of apical periodontitis checked by periapical radiographs; absence of pain to the vertical and horizontal percussion.	Teeth with cuspal loss; cervical margin of cavity in dentin and cementum; and advanced periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-8s4gfg	Computer aid to carry out school activities in individuals with Down Syndrome	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1931	Assistive Technology Device for conducting school activities in individuals with Down Syndrome: enhancement of the Augmentative and Alternative Communication	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8s4gfg	<NULL>	present the Informed Consent Form (TCLE); to sign the Free and Informed Consent Term (TALE); to understand the proposed task; able to perform the necessary movement; do not present symptoms of pain or discomfort during the execution of the tasks.	do not understand the task; do not want to perform the movement necessary to perform; have symptoms of pain or discomfort during the execution; limitations of movements in the upper limbs; visual limitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8bfjgk	Computer Games for Autistic Communication	Recruiting	Intervention	2018-06-29	<NULL>	<NULL>	1946	Virtual Reality and Augmentative and Alternative Communication in Autism	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8bfjgk	<NULL>	Initially, all the individuals with a diagnosis of ASD; of both sexes; will be included in the study; who will follow up at APAE in Vitória-ES and Vila Velha-ES (for GE) and FMABC Outpatient Neurology; individuals with typical development; paired by age; and gender to the GE; members of the public school Dr. Geraldo José Rodrigues Alckmin in Potim, SP (for the GC).	Individuals who can not understand the orientations in relation to the proposed task; present some limitation of movement of the upper limbs; and / or limitation in visual acuity that prevents them from performing the game; and / or are unable or unwilling to complete the proposed task will be excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-78zmwr	Computer games for people with amyotrophic lateral sclerosis	Recruiting	Intervention	2018-11-30	<NULL>	<NULL>	2352	Virtual work performance analysis in people with Amyotrophic Lateral Sclerosis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78zmwr	<NULL>	Medical diagnosis of amyotrophic lateral sclerosis with cognitive conditions of task comprehension (assessed by means of two attempts of each task); for inclusion in the control group, people can not have neurological impairments; authorization of the participant or their caregivers, with due signing of the informed consent form	Individuals who can not understand the guidelines in relation to the proposed task; present some limitation of movement of the upper limbs; and / or limitation in visual acuity that prevents playing the game; and / or are unable or unwilling to complete the proposed task will be excluded from the search	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-96cjsh	Computer games on elderly socialization	Recruiting	Intervention	2016-05-31	<NULL>	<NULL>	879	Virtual Reality games on elderly socialization	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-96cjsh	<NULL>	All the elderly over 60 years, of both sexes, spontaneously enrolled in the informatics beginner class for seniors of the Reference certer of elderly in Ribeirão Pires.	Those who have less than 75% of frequency in the classes between the assessments and/or do not complete the three moments of assessment. Individuals with some motor impairment of the upper limbs, which prevents them to practice the games, will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-46dvfxf	Concentration of Brain-Related Proteins in the blood of adults with Autism and their relationship with neuropsychological tests	Recruiting	Observational	2024-10-09	<NULL>	<NULL>	7416	Evaluation of blood concentration of BDNF and proBDNF in adult patients diagnosed with Autism Spectrum Disorder and its correlation with neuropsychological assessment parameters in a brazilian population	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-46dvfxf	<NULL>	Adults aged between 18 and 65 years; previous diagnosis of Autism Spectrum Disorder (ASD) confirmed by a psychiatrist (for the ASD group);residents in Brazil; ability to provide informed consent, or having a legal representative capable of doing so in case of incapacity; availability to complete the Wechsler Adult Intelligence Scale, Beck Depression Inventory - Second Edition, Beck Anxiety Inventory, Autism Diagnostic Observation Schedule and Autism Diagnostic Interview-Revised instruments; willingness to provide biological samples for Brain-Derived Neurotrophic Factor (BDNF) analysis; both genders	Severe neurological or psychiatric conditions, such as schizophrenia or severe bipolar disorder; severe sensory or motor deficits; adults unable to consent and without a legal representative; ongoing medication treatments that may significantly influence behavior or cognitive responses; medical conditions that prevent safe collection of biological samples for Brain-Derived Neurotrophic Factor (BDNF) analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-63hzd3	Consequences of COVID-19 in dialytic patients	Recruiting	Observational	2020-10-06	<NULL>	<NULL>	4329	Prospective study of COVID-19 in dialytic patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Associação Evangélica Beneficente de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-63hzd3	<NULL>	Dialytic patients from Centros de Nefrologia do Hospital Evangélico de Belo Horizonte; patients with diagnosis of COVID-19 admited in Hospital Evangélico de Belo Horizonte, older than 18 years old.	Refuse to sign the informed consent form, patients younger than 18 years old and vulnerable populations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-6xfz7pc	Consequences of Covid-19 infection in patients hospitalized for the disease: a study with an emphasis on pain	Recruitment completed	Observational	2021-10-25	<NULL>	<NULL>	5001	The impacts of the Covid-19 pandemic on patients affected in moderate and severe forms - an observational study with an emphasis on the presence of Pain	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-10-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6xfz7pc	<NULL>	Over 18 years old; of both genders; diagnosed with Covid-19 and who needed hospitalization	Patients with cognitive impairment perceived during the interview; with significant visual or auditory changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-2x6hmbv	Consequences of Covid19 on the cardiovascular system of hypertensive patients	Not yet recruiting	Intervention	2022-10-14	<NULL>	<NULL>	5662	Consequences of Sars-Covid19 on the cardiovascular autonomic control of hypertensive patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-27	Faculdade de Medicina de Ribeirão Preto - FMRP/USP	Faculdade de Medicina de Ribeirão Preto - FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-2x6hmbv	<NULL>	Homens; hipertensos ou normotensos; idade entre 35 e 55 anos; acometidos por COVID-19 entre 6 e 24 meses antes; assintomático, leve ou internados em enfermaria por baixa saturação de oxigênio	Smokers; diagnosis of cognitive disturbances, musculoskeletal disorders, and chronic diseases; during the period of transmission of the Covid-19 disease; patients who had the severe form and required ICU admission; previous home or outpatient physical therapy treatment; current use of drugs that interfere with cardiac functionality and cardiovascular autonomic control	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-37gdst	Consequences of Dental Absence on Mastication Function of the elderly	Recruitment completed	Intervention	2017-10-31	<NULL>	<NULL>	1454	Consequences of Total Edentulism on Masticatory Function, Masseter Thickness, and Oral Stereognosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-27	Faculdade de Odontologia de Piracicaba (Fop/Unicamp)	Faculdade de Odontologia de Piracicaba (Fop/Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-37gdst	<NULL>	Good general health; Aged between 60 and 85 years old; Totally edentulous in both dental arches, for a minimum period of 6 months, and who do not use one of them, for at least, three months.	Patients with physical or mental impairment, with a presence of parafunctional habits or history of temporomandibular joints or chewing muscles symptomatology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-8zh26b	Consequences of tooth movement with fixed braces in bone grafted regions	Recruitment completed	Intervention	2019-12-11	<NULL>	<NULL>	3272	Effects of the movement of the teeth with orthodontic appliance, in graft bone regions	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-05	Faculdade de Odontologia da Universidade Federal da Bahia	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8zh26b	<NULL>	"Patients of both genders, older than 18 years, who are being treated at the UFBA Orthodontics specialization clinic will be included.
They have had lower first molars absent, with atrophy of the bony ridge in vestibular-lingual thickness; presence of second and third adjacent lower molars; first molar superior extruded antagonist and general good health. In addition, they should have in their treatment plan autogenous bone graft in the edentulous region of the first lower molar, uni or bilateral; mesialization of the second and third lower molars, uni or bilateral; and intrusion of the first molar upper antagonist."	Patients with systemic diseases or changes or syndromes will be excluded; medicines that may affect bone metabolism and or root resorption index; and who had a history of trauma in the teeth studied. In addition, smokers and pregnant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-97phmj	Conservative caries treatment	Recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3787	Minimally invasive treatment of approximal carious lesions: a randomized clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-97phmj	<NULL>	Older adults and teenagers over thirteen years old with permanent teeth with a proximal radiographic image located on the entire enamel or even external half of dentin with cavitation	Teeth with fixed orthodontic appliance that make clinical or radiographic examination impossible; teeth that present occlusal restoration with communication to the lesion of the proximal surface; teeth with lesions that extend to the root surface	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-4mtq8d9	Conservative steel crowns for the management of dental enamel defects in permanent molars: a randomized controlled trial	Recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6116	Hall Technique for the management of Hypomineralized first permanent molars: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Programa de Pós-graduação Stricto sensu em Odontologia - Faculdade de Odontologia - Universidade do Estado do Rio de Janeiro	Programa de Pós-graduação Stricto sensu em Odontologia - Faculdade de Odontologia - Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4mtq8d9	<NULL>	Children with at least one first permanent molar affected by molar incisor hypomineralization (MIH) with post-eruptive breakdown; atypical carious lesions; or atypical restoration affecting at least two tooth-surfaces and involving at least one cusp will be eligible for the study	Children presenting other developmental enamel defect than molar incisor hypomineralization (e.g., amelogenesis imperfecta, severe fluorosis); chronic health conditions; symptoms of temporomandibular joint (TMJ) dysfunction, children unable to cooperate with treatment and first permanent molar with signs and/or symptoms of pulp involvement or with orthodontic appliances will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-6fy2t8m	Conservative treatment for facial pain  of muscular origin  in patients with facial  and neck pain	Recruitment completed	Intervention	2025-09-25	<NULL>	<NULL>	8311	Conservative treatment of muscle Temporomandibular Dysfunction in patients with Temporomandibular Dysfunction and cervical pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6fy2t8m	<NULL>	Patients between 18 and 65 years of age; men and women; classification of muscular Temporomandibular Disorders according to the diagnostic criteria in research for Temporomandibular Disorders (myofascial pain and myofascial pain with limitation of opening); with pain for more than 3 months; complaint of pain in the face and mechanical-postural Cervicalgia grade I or II; according to Neck Pain Task Force for more than 3 months on the Numerical Scale of Pain between 3- 8 cm; agreement and signing of the Free and Informed Consent Form	Patients with neuromuscular diseases; autoimmune or rheumatological diseases; cervical pain that is not of postural mechanical origin; cervicogenic neck pain; cervical trauma related to pain; use of orthodontic appliances; have changed or started medication in the last 3 months; practice of physical activity started or changed in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-8ssqsw	Conservative treatment in female urinary incontinence: physiotherapy and bladder retraining comparative study	Recruitment completed	Intervention	2017-12-14	<NULL>	<NULL>	1520	Conservative treatment in female urinary incontinence: biofeedback and vesical training  comparative study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	universidade federal do rio grande do sul	hospital materno infantil presidente vargas	https://ensaiosclinicos.gov.br/rg/RBR-8ssqsw	<NULL>	Women over 18 years-old with stress urinary incontinence in the absence of genital prolapse greater than 2	Cognitive impairment; pregnancy or postpartum period until 6 months after birth; women on medications like antidepressants or diuretics of early start or changing dosage at the recruitment phase; other types of urinary incontinence; genital prolapse; urethral esfincter deficiency with leakage point below sixty centimeters of water	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-4r6jhy6	Conservative versus surgical treatment of grade III acromioclavicular dislocations	Not yet recruiting	Intervention	2022-12-13	<NULL>	<NULL>	5761	Conservative versus surgical treatment of grade III acromioclavicular dislocations: prospective and randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-15	Centro de Traumatologia do Esporte da Escola Paulista de Medicina	Centro de Traumatologia do Esporte da Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-4r6jhy6	<NULL>	Both genders; over 18 years of age; type III acromioclavicular dislocations with up to 21 days of evolution; absence of acromioclavicular dislocation in the shoulder in question; absence of previous surgery on the shoulder in question; absence of concomitant fracture of the acromion, coracoid or clavicle; signing the consent form.	Patients who did not meet the return schedule; patients in whom radiological examinations were not performed correctly; patients who did not comply with the proposed rehabilitation program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-4rg5yc8	Constipation and non-drug treatment alternative	Recruiting	Intervention	2025-10-07	<NULL>	<NULL>	8376	Auriculotherapy and Constipation in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-11	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4rg5yc8	<NULL>	Volunteers aged 60 or older; Mini Mental Health Exam score greater than 18 points for people without formal education and greater than 24 for those with formal education; diagnosis of functional constipation according to the Rome IV criteria	People with anatomically altered ears; signs in the ear that indicate infection, such as sores, redness, and sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-2gmhns	Constipation in students and its relationship to diet	Recruitment completed	Intervention	2015-05-11	<NULL>	<NULL>	468	Constipation in academics and its relationship with food consumption: prevalence and nutritional intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2gmhns	<NULL>	Constipation diagnosed from the Rome III Criteria	Under 18. Age of 60.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-9h7ckx	Consumption of fruits and vegetables in promoting health services	Recruitment completed	Intervention	2015-08-12	<NULL>	<NULL>	577	Consumption of fruits and vegetables in promoting health services in Belo Horizonte, Minas Gerais: associated factors and nutritional interventions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-10	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de São João del-Rei - UFSJ	https://ensaiosclinicos.gov.br/rg/RBR-9h7ckx	<NULL>	Members of the Academia da Saúde Program; both genders; aged between 20 and 90 years.	Pregnant; mental disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-3stzx6f	Consumption of Interesterified Fat and its action on the Metabolism of healthy adults	Recruiting	Observational	2024-01-16	<NULL>	<NULL>	6733	Estimated dietary intake of Interesterified Fat and its relationship with Metabolic Changes in a sample of adults	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-09	Fundo de apoio ao ensino, pesquisa e extensão da Universidade Estadual de Campinas (FAEPEX/UNICAMP)	Fundo de apoio ao ensino, pesquisa e extensão da Universidade Estadual de Campinas (FAEPEX/UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-3stzx6f	<NULL>	Individuals with the cognitive capacity to understand the study procedures and sign the Free and Informed Consent Form (TCLE), of both sexes, aged between 20 and 59 years old, and with a body mass index (BMI) of 20, will be considered eligible 20 kg/m² to 29.9 kg/m².	Individuals with catabolic diseases or those that directly or indirectly affect food intake (kidney, liver, oncological, intestinal inflammatory diseases, genetic syndromes and autoimmune and/or immunosuppressive diseases), individuals who have suffered a greater body weight change will be considered ineligible. than 5% in the last 6 months, pregnant women and nursing mothers and athletes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-7pmvs5	Consumption of nuts on metabolism and food intake in Overweight Subjects	Recruitment completed	Intervention	2018-04-30	<NULL>	<NULL>	4242	Acute effect of nuts beverage consumption on metabolism and food Ingestion in Overweight Subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-7pmvs5	<NULL>	The following inclusion criteria will be considered: men and women aged 19-59 years; body mass index (BMI) between 26 and 34.9 kg / m2; fat percentage&gt; 25% for men and&gt; 33% for women, absence of other chronic and acute diseases as well as eating disorders and allergies; do not make regular use of anti-inflammatory drugs, corticosteroids, antibiotics or that affect appetite and / or energy, lipid and glucose metabolism; have not had any infectious or allergic episodes in the last month; not being on diets for weight loss; stable weight in the last 3 months (fluctuation up to 5 kg); do not present aversion or allergy to cashew nuts and brazil nuts; no alcohol intake greater than 21 units (168g) per week; do not be a smoker.	Volunteers who do not follow the study protocol will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-2wjncp	Continued treatment with darunavir/ritonavir in children and adolescents aged 3 years and above with HIV-1	Recruitment completed	Intervention	2017-09-28	<NULL>	<NULL>	1404	Continued access to Darunavir/Ritonavir (DRV/RTV) in HIV-1 infected children and adolescents aged 3 years and above	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-10-13	Hospital Geral de Nova Iguaçu	Janssen Research and Development*	https://ensaiosclinicos.gov.br/rg/RBR-2wjncp	<NULL>	"Male or female subjects, aged 3 years and above.Subject has completed the TMC114-C212, TMC114-TiDP29-C228 or TMC114-TiDP29-
C230 trial, and in the opinion of the investigator continues to receive benefit from using Darunavir. Darunavir is not commercially available for the pediatric subject, is not reimbursed, or cannot be
accessed through another source in the region the subject is living in. Subject  and the parent(s) or legal representative(s)have signed the Informed Consent Form voluntarily."	"Any condition which, in the opinion of the investigator, could compromise subjects’ safety or adherence to treatment with Darunavir. Any active clinically significant disease or findings of medical history, laboratory or physical examination that, in the opinion of the investigator, would compromise subjects’ safety during treatment with Darunavir. Previously demonstrated clinically significant allergy or hypersensitivity to Darunavir or to Ritonavir. Pregnant or breastfeeding female subjects. Female subject of childbearing potential without use of effective birth control methods or
not willing to continue practicing these birth control methods for at least 30 days after the end of the treatment period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-5z58rzp	Continued use of extra virgin Olive Oil fat solution during Hemodialysis session to decrease inflammation in patients with Chronic Kidney disease	Recruitment completed	Intervention	2022-05-31	<NULL>	<NULL>	5413	Continued use of Lipid Emulsion with extra virgin Olive Oil, Intradialytic, to decrease the inflammatory state in Chronic Kidney patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-31	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade de Jaén	https://ensaiosclinicos.gov.br/rg/RBR-5z58rzp	<NULL>	All patients over 18 years of age; more than six months in hemodialysis treatment; with adequate dialysis index greater than 1.2	Not accepting to be part of the research; chemotherapy or radiotherapy in the last three months; corticosteroid therapy greater than 7.5 mg/d; acute bacterial infection; impairment of vascular access; severe liver failure; acute immunodeficiency virus; severe hypertriglyceridemia above 400 mg; difficulty in adjusting blood glucose; pregnancy; hypersensitivity to any component of the lipid emulsion; intrahepatic cholestasis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-4z7bc6	Contraceptive implant in adolescent postpartum	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	6735	Subdermal implant in adolescent postpartum: non-randomized clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-25	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4z7bc6	<NULL>	Adolescent postpartum until 19 years	Adolescent postpartum who do not wish to use any contraceptive method; who present absolute contraindication to the use of the contraceptive method chosen according to WHO or who are not able to attend childbirth review appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-3h2gv8r	Contrast-induced renal disease in renal patients	Terminated	Intervention	2023-03-31	<NULL>	<NULL>	5979	Contrast-Induced Nephropathy: evaluation of preventive measures, based on serum levels of Creatinine and Cystatin C, in patients with Moderate and Severe Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Hospital Geral de Goiania dr Alberto Rassi	Daniel César Magalhães Fernandes	https://ensaiosclinicos.gov.br/rg/RBR-3h2gv8r	<NULL>	Hospitalized patients with peripheral arterial occlusive disease requiring contrast-enhanced imaging procedures (diagnostic and/or therapeutic arteriography only). Signed informed consent (ICF) was obtained. Patients of any age. Any gender were eligible. Individuals with normal renal function, defined by an estimated glomerular filtration rate (eGFR)&gt;60mL/min/1.73m², were included in the control group. Patients with impaired renal function consistent with moderate chronic kidney disease (eGFR between 30–59 mL/min/1.73m²) .Severe chronic kidney disease (eGFR &lt; 30 mL/min/1.73m²) were also included	Patients with congestive heart failure. Septic or cardiogenic shock. Patients who used nephrotoxic medications or iodinated contrast in the 48-hour period before the evaluation. Patients with acute kidney injury or chronic kidney disease on dialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-4ttgs2j	Contribution of cardioprotective dietary guidance on Inflammation and Oxidative Stress after Myocardial Infarction and Stroke in volunteers assisted at a SUS reference service in the state of Alagoas, Brazil	Recruitment completed	Intervention	2024-06-27	<NULL>	<NULL>	7108	Contribution of cardioprotective dietary guidance on Inflammatory and Oxidative Stress markers in obese adults and elderly survivors of Stroke and Acute Myocardial Infarction in a SUS Reference Service in the State of Alagoas	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-03	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-4ttgs2j	<NULL>	Volunteers who survived Acute Myocardial Infarction (AMI) and Cerebrovascular Accident (CVA), hospitalized for treatment of these conditions. Aged ≥ 20 years. Of both sexes. Obese (coexistence of overweight and body fat in obese adults and elderly – Body Mass Index BMI≥ 25 kg/m2 and &gt; 27 kg/m2, for adults and the elderly, respectively, i.e., overweight BMI for both age groups and, necessarily, increased waist circumference (WC) ≥ 80 cm increased for women and ≥ 90 cm for men) and/or excess body fat according to Triceps Skinfold (PCT) - TSF &gt; 95th percentile for sex and age OR % adequacy &gt; 120% when the PCT obtained / PCT percentile 50 x 100 &gt; 120%, increased WC and PCT constitute obesity/excess adipose tissue, in individuals with overweight/overweight BMI). Clinically stable. With conditions for telephone contact and/or other form of remote contact after hospital discharge	Individuals hospitalized for treatment of Acute Myocardial Infarction (AMI) and Cerebrovascular Accident (CVA). With – Body Mass Index BMI &lt; 25 kg/m2 (adults) and &lt;= 27 kg/m2 (elderly). Clinically unstable. With special needs (assisted feeding, such as enteral feeding). No conditions for telephone contact and/or other form of remote contact after hospital discharge. Pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-2m2q5c	Contribution of Changing Eating Habits to reduce the risk of Heart Disease and improve the quality of life of wheelchair  basketball players	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1771	Contribution of Nutritional Intervention to reduce the risk of Cardiovascular Diseases and improve the quality of life of wheelchair basketball players	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-23	Centro Universitário de Patos de Minas MG	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-2m2q5c	<NULL>	Athlete of the basketball team in wheelchairs; both genders; aged between 18 and 50 years; practicing the activity for more than thirty days; accepting to participate in the research	Being on medication for weight loss; lipid profile control or glycemic control; being in the use of supplements that interfere in the glucose or lipid metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9n4t4yt	Contributions of Auriculotherapy in the symptoms of anxiety and depression in health professionals	Recruitment completed	Intervention	2024-09-10	<NULL>	<NULL>	7329	The use of Integrative and Complementary Practices - PICs -  in the city of Londrina - UEL/ Londrina Cuty Hall	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-9n4t4yt	<NULL>	Health workers over 18 years of age; both sexes; who agreed to participate in the research; who received three auriculotherapy sessions	Health workers who did not agree to participate in the research;  or who accepted but did not receive three auriculotherapy sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-6vp3hq	Contributions of dance in the quality of life of the elderly	Recruitment completed	Intervention	2019-05-06	<NULL>	<NULL>	2658	The dance as a resource of the occupational therapist with the elderly: contributions in the quality of life	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-16	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6vp3hq	<NULL>	Age equal or superior to 60 years; of both genders; have four years or more of schooling; without cognitive deficits by the Mini Mental State Examination; without neuromotor deficiencies reported; without related cardiac and respiratory problems.	Be less than 60 years old; have indicative of cognitive deficits by the Mini Mental State Exam; have less than four years of schooling; to present neuromotor deficiencies; have heart and respiratory problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-2zv39y	Contributions of Pray on the High Pressure, Heart Rate, Respiratory Rate and Anxiety of People With Kidney Disease in Dialysis Treatment	Recruitment completed	Intervention	2016-03-01	<NULL>	<NULL>	726	Contributions of Pray on Hypertension, Heart Rate, Respiratory and Anxiety of people with CRF undergoing Dialysis Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-20	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2zv39y	<NULL>	Having arterial hypertension 140 / 90 mmHg; high anxiety scores equal to or above 50; as the STAI instrument; take part in the study; to be clinically stable; oriented in time space and person; wish to receive the pray	Presence of deafness; presence limitations that compromise talks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-524z9n	Contributions to Prenatal Care	Data analysis completed	Intervention	2016-05-23	<NULL>	<NULL>	861	Contributions Theoretical and Practical for Prenatal Care for Diabetic Pregnant	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-05-02	Universidade Federal do Rio de Janeiro - UFRJ	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-524z9n	<NULL>	adult women ( aged 20 to 49 years), diagnosed with diabetes mellitus prior to pregnancy or during pregnancy with gestational age below 28 weeks and, of singleton pregnancy.	diabetic pregnant women with chronic diseases or diabetes mellitus complications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2dd6x6r	Control of fluid volume in people on hemodialytic regime	Recruitment completed	Intervention	2023-06-09	<NULL>	<NULL>	6144	Effectiveness of the nursing intervention control of fluid volume in people on hemodialytic regime: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-2dd6x6r	<NULL>	Having a medical diagnosis of Chronic Kidney Disease. Be on hemodialysis treatment for at least 8 months. Be registered and monitored at the Baturité dialysis clinic. Be over 18 years old. Both genders. Having the nursing diagnosis excessive fluid volume. Having scored less than 4 points on the expected fluid balance nursing outcome scale	Be in temporarily or permanently impaired mental conditions that make it impossible for you to be aware of and cooperate with research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-99395b	Control of hormone concentrations produced by the stomach and intestine by the use of a supplement containing yerba mate, guarana and damiana in women with overweight	Recruitment completed	Intervention	2015-07-30	<NULL>	<NULL>	567	Modulation of gastrointestinal hormones by supplementation herbal extract containing yerba mate, guaraná and damiana in overweight women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-15	Universidade Federal de Goiás	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-99395b	<NULL>	BMI 25 and 39,9 kg/m²;20 Sedentary women and healthy;Aged 20 to 50 years	Unavailability of one day/ week for the study day;participants with autoimmune liver kidney or hypothyroidism diseases; gastrointestinal symptoms requiring treatment; bariatric surgery;participants of a food restriction program or that practiced diet in the last 12 months to lose or control weight;without use current adherence to a specific food avoidance diet;taking medication or nutritional supplements known to affect appetite or weight;taking medication immunosuppressive or insulin; being pregnant or planning to become pregnant or breastfeeding; menopause;chronic alcoholics;history of anaphylaxis to food; food allergies, including caffeine or other compound present in the supplement and any of the study foods;intolerance or allergy to lactose	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-3jm5y2	Control of urinary loss in men undergoing prostate surgery	Recruitment completed	Intervention	2020-07-24	<NULL>	<NULL>	4034	Effectiveness of integrative and complementary practices associated with pelvic muscle training to control urinary incontinence after radical prostatectomy: randomized clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2019-04-12	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3jm5y2	<NULL>	Preserved locomotor, visual, auditory and swallowing capacity; Have a preserved cognitive function, verified by means of a six-item cognitive impairment test; Present urinary incontinence with the need to use at least one or more absorbents daily; Have a loss greater than one gram assessed using the Pad Test; Have removed the delayed bladder catheter within 10 to 15 days	Do not respond to three attempts at contact made by the researcher; Need for readmission; Be in chemotherapy or radiotherapy treatment; Presence of rectum urethral fistula; Presence of urinary incontinence before the surgical procedure; Urinary tract infection (UTI), with urine culture test showing multi-resistant bacteria and more than one cycle of antibiotic therapy; Infection, inflammation or injury to the ear; Allergy to metal or micropore; Not having financial conditions and availability to be at the place of the study; Use of other complementary therapies up to three months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-7t6rm86	Control of vertical facial growth in children in mixed dentition	Recruiting	Intervention	2025-11-25	<NULL>	<NULL>	8568	Children in mixed dentition with Angle Cl II malocclusion and hyperdivergent facial pattern: analysis and treatments	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-27	Faculdade de Odontologia da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Age range between 7 and 8 years; both sexes; may or may not present with mild or moderate apnea and/or hypopnea; who are in the mixed dentition phase; with all four upper and lower permanent incisors and first molars erupted; in addition to still having at least the four upper and lower deciduous molars; who present with an increase in the lower third in relation to the middle third of the face; mandibular retrusion and a decrease in the transverse dimensions of the upper arch	Individuals with decayed teeth or teeth requiring extensive treatment or with periodontal disease; those with temporomandibular dysfunction; rheumatoid arthritis; those using medication that interferes with growth; those with severe sleep apnea; or whose general health condition contraindicates orthodontic treatment; those with congenital problems involving the temporomandibular joint (TMJ) and/or the cranial, orofacial, and cervical regions; those who are unavailable to participate in the study or unable to answer the quality of life questionnaires	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:41
RBR-69dym8p	Controlling symptoms in people with trigeminal nerve pain	Recruiting	Intervention	2025-05-16	<NULL>	<NULL>	8008	Controlling symptoms in people with Trigeminal Neuralgia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-17	Universidade Federal de Alfenas - Unifal	Casa de Caridade Nossa Senhora do Perpétuo Socorro - Santa Casa de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-69dym8p	<NULL>	Patients aged 18 years or older; regardless of gender; patients with trigeminal neuralgia (TN) who have not responded to the usual clinical treatment; who have not previously undergone any surgical procedure for the treatment of TN; who are physically and cognitively able to understand the Informed Consent Form and participate in the study by answering the instruments used	Patients who are delirious or mentally confused at the time of the approach; patients with psychiatric symptoms (psychosis, suicidal ideation, bipolar disorder); patients with an intense pain crisis that makes it impossible to respond to the study instruments; other personal and behavioral circumstances that would limit compliance with the study requirements, or judged by the doctor in charge to be incompatible with the possibility of participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-7xzcmg7	Conventional Percutaneous surgery vs. Endoscopic Combined Intrarenal surgery for the treatment of large Kidney Stones	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4983	Conventional percutaneous nephrolithotomy with flexible antegrade nephroscopy vs. Endoscopic Combined Intrarenal Surgery (ECIRS): a prospective randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-31	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xzcmg7	<NULL>	"Adults aged 18 or over with kidney stones greater than 20 mm, candidates for PCNL in Barts position; Signed informed consent	."	Impossibility to perform retrograde ureteroscopy (e.g., urinary reconstruction); Contraindications to PCNL (untreated urinary infection, uncorrected coagulopathy, ipsilateral kidney tumor, pregnancy); Concurrent ureteral stone or simultaneous bilateral approach; Uncontrolled comorbidities; Refusal to sign consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-9vpm9c	Cooling as an adjuntive therapy to angioplasty in patients with myocardial infarction.	not yet recruiting	Intervention	2012-05-21	<NULL>	<NULL>	130	Cooling as an adjuntive therapy to percutaneous intervention in patients with acute myocardial infarction - &quot;cool-mi incor&quot; - version 2.0, february 2011.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	ZOLL CIRCULATION INC	ZOLL CIRCULATION INC	https://ensaiosclinicos.gov.br/rg/RBR-9vpm9c	<NULL>	Patients aged&gt; 18 years; The patient must have symptoms consistent with acute myocardial infarction (chest pain, or arm pain, etc.) and no improvement with nitroglycerin with onset of symptoms more than 30 minutes but less than six hours before its entry in the emergency room; Anterior wall AMI or less with ST segment elevation&gt; 1 mm in two or more contiguous leads; The patient must be eligible for the PCI; The expected time until the patients undergoing PCI should allow at least 30 minutes of cooling before PCI; The patient or legal guardian of the patient agrees and is willing to sign the informed consent to participate in the clinical study.	The patient had a previous myocardial infarction within one month; The patient has cardiogenic shock (systolic blood pressure (SBP) &lt;80 mmHg and unresponsive to volume or SBP &lt;100 mmHg with vasopressors, or need for an intra-aortic balloon - BIA); The patient has known hypersensitivity to hypothermia, including a history of Raynaud&apos;s disease; The patient has known hypersensitivity or contraindication to aspirin, heparin, or hypersensitivity to contrast that can not be adequately premedicated; The patient has known history of blood diathesis, coagulopathy, cryoglobulinemia or sickle cell anemia, or refuse a blood transfusion; The patient has a height &lt;1.5 m (4 feet 11 inches); The patient is known to be pregnant or expect to become pregnant before 1 month of follow-up; The patient has known hypersensitivity to buspirone or meperidine hydrochloride and / or treated with a monoamine oxidase inhibitor in the last 14 days; The patient has known history of hepatic or renal impairment, untreated hypothyroidism, Addison&apos;s disease, benign prostatic hypertrophy or urethral stricture, which in the opinion of the physician, would be incompatible with the administration of meperidine; To prevent nephrotoxicity gadolinium, patients with renal failure known as a set Glomerular Filtration Rate of less than 30 cubic centimeters per minute; Patients with vena cava filter; The patient has a life expectancy of pre-MI &lt;1 year due to underlying medical conditions or pre-existing comorbidities; The patient has known history of drug or alcohol addiction, or is unable to understand or follow the instructions; The patient is currently enrolled in the study COOL-MI or other drug research or study device that has not completed the primary endpoint or that clinically interferes with the outcomes of the COOL-MI study INCOR.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-9m57m2	Copaíba Oil in the prevention and treatment of wounds in the oral cavity	Recruitment completed	Intervention	2020-02-11	<NULL>	<NULL>	3475	Copaiba Oil in prevention and treatment of Oral Mucositis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9m57m2	<NULL>	Including individuals of both sexes, aged 18 years or older, diagnosed with solid or hematologic malignancy and under chemotherapy or radiotherapy, the latter in the head and neck region, at the Oncology Center of the Oswaldo Cruz University Hospital, to agree to conduct this study after signing the Informed Consent Form, thus allowing the use, after random draw, of one of the three methods used in this study for prevention and treatment of chemoinduced and radioinduced oral mucositis.	Individuals who do not meet the inclusion criteria; Individuals who meet the inclusion criteria but disagree with the study and / or individuals who initially allow the study and then express their desire to abandon the study will be excluded; Also individuals who abandon the oncological or dental treatment for oral mucositis control during the research period, or who die without being able to complete the analysis of oral condition and mucositis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-4yz96t	Core and Mckenzie Exercises in Non-Specific Chronic Low Back Pain in Hospital Hygiene Workers	Recruitment completed	Intervention	2018-09-12	<NULL>	<NULL>	2192	Comparative Effects of Core and Mckenzie Stabilization Exercises on Non-specific Chronic Low Back Pain in Hospital Workers of the Santa Luzia Hospital of Capão Da Canoa,	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	AESC - Associação Educadora São Carlos	AESC - Associação Educadora São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4yz96t	<NULL>	Professionals in the sanitation service sector; both sexes; with symptomatology of nonspecific lumbar pain superior to grade three in the Visual Analogue Pain Scale (VAS); age between 18 and 60 years; ability to perform exercises.	History of current neurological, infectious and systemic diseases; Lumbar pain of root characteristic; pregnancy or suspected pregnancy; any co-operative dysfunction or inability to respond to questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-34d3jv2	Corneal injury treatment protocol using 50% Autologous Serum Eye Drops	Recruiting	Intervention	2023-11-27	<NULL>	<NULL>	6614	Interventional clinical protocol for assessing the therapeutic efficacy of 50% Autologous Serum Eye Drops in the treatment of corneal epithelial defects in Inflammatory ocular surface diseases	<NULL>	1-2, n/a, n/a	1-2	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-34d3jv2	<NULL>	Age 18 to 80 years. Both genders. Confirmed diagnosis of one of the following pathologies: Sjögren &apos;s syndrome, Moderate to severe non- Sjögren&apos;s dry eye, Stevens-Johnson syndrome, Graft versus host disease, Neurotrophic keratitis, Neurotrophic pain. Presence of corneal epithelial defect without improvement after treatment with preservative-free lubricating eye drops for at least 14 days. Absence of active infection on the ocular surface. No recent use of the following medications or performance of the following procedures: anticoagulants/ anti- platelet aggregation, blood product eye drops in the last 3 months, eye surgery in the last 6 months. Does not present any of the following conditions: poorly controlled systemic disease, active infection or advanced-stage cancer, pregnancy or breastfeeding. There are no contraindications to blood donation:  positive serology for HIV I and II or HTLV 1/2 or hepatitis B or hepatitis C or syphilis or Chagas disease according to Ordinance 158 of 02/04/2016 of the Ministry of Health – Brazil, anemia (hemoglobin level &lt; 11.0 mg/dl) or thrombocytopenia (platelet level &lt; 150 x 10 9 /L). Ability to adhere to the treatment and follow-up protocol during the study period and provide written consent for participation	Diagnosis of active corneal infection. Pregnancy diagnosed after beginning the protocol. Loss of clinical follow-up. Incorrect adherence to treatment, with application of less than 70% of the expected daily dose or remaining without use for more than one full day a week. Inadequate storage and care of eye drops. Need for other interventions to treat epithelial defect	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-6f65qp	Correction of the anterior cruciate ligament injury with the use of the functional graft clinical and microscopic characteristics of the maintenance of the muscle residue of the flexor tendons.	Recruitment completed	Intervention	2020-08-13	<NULL>	<NULL>	4119	Reconstruction of the anterior cruciate ligament using a functional graft clinical and histological characteristics of the maintenance of the flexor tendon muscle remnant.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-07	Universidade Federal de São PauloUnifesp	Universidade Federal de São PauloUnifesp	https://ensaiosclinicos.gov.br/rg/RBR-6f65qp	<NULL>	patients with previous ACL injury, healthy; both genders; non smokers; age between 18 and 60 years; weight within the range of 15% of the weight considered normal for men and women, taking into account height and physical structure.	Smoking patients were excluded; history of alcohol or drug abuse; diagnoses of voluntary smoking pathologies; history of previous surgeries or angular deformities in the operated limb	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-4n4c4z	Correction of umbilical hernia with anterior muscle tissue compared to posterior muscular tissue	Recruiting	Intervention	2018-03-27	<NULL>	<NULL>	1690	Umbilical herniaplasty onlay versus sublay	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Hospital Presidente Vargas	Hospital Presidente Vargas	https://ensaiosclinicos.gov.br/rg/RBR-4n4c4z	<NULL>	Female patients; 18 years of age or older; presenting with primary umbilical hernia.	Patients with relapsed umbilical hernia; need for another concomitant surgical procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-2k9mkz6	Correlation between clinical and socioeconomic characteristics with the grade of Carpal Tunnel Syndrome	Recruiting	Observational	2024-02-26	<NULL>	<NULL>	6807	Correlation between clinical and socioeconomic characteristics and neurophysiological severity in Carpal Tunnel Syndrome	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-02	Universidade do Estado do Rio Grande do Norte, Faculdade de Ciências da Saúde (FACS)	Instituto André Camurça	https://ensaiosclinicos.gov.br/rg/RBR-2k9mkz6	<NULL>	Patients of both genders; over 18 years of age; referred for electroneuromyography due to suspected diagnosis of carpal tunnel syndrome unilateral or bilateral; with compatible symptoms and confirmation of this diagnosis by electroneuromyography	Patients who have already undergone decompression surgery for carpal tunnel syndrome; patients with concomitant polyneuropathy; patients with amputation of the fingers; patients whose electroneuromyography indicates an other diagnosis than carpal tunnel syndrome; patients with anatomical variations in nervous structures capable of modifying and confusing the median nerve conduction study; patients who cannot tolerate the electroneuromyography exam due to discomfort with electrical stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-3bkshg	Correlation between post-surgery urine bleeding degree for prostatic increase and surgery outcomes, evaluated by a new scale of urine bleeding	Recruiting	Observational	2017-11-28	<NULL>	<NULL>	1504	Correlation between post-surgery hematuria degree for benign prostatic hyperplasia and intra and perioperative outcomes, evaluated by a new hematuria scale	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Hospital Brigadeiro UGA V-SP	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3bkshg	<NULL>	Patients undergoing Benign Prostatic Hyperplasia surgery; any age.	Prostate cancer; Bladder lithiasis; Bladder cancer; Anticoagulants use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-752vkn	Correlation existence between lumbar curvature, flexibility, low back pain and physical activity in Paraná Coast surfers	Recruitment completed	Observational	2015-05-18	<NULL>	<NULL>	478	Correlation between lumbar curvature, lumbar flexibility, low back pain and physical activity level surfers in the municipality of Matinhos-PR	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-752vkn	<NULL>	Healthy volunteer; surfers for at least 6 months in the coast of Paraná; both genders; aged between 18 and 42 years.	Volunteers with sequelae of peripheral neurologic and vascular diseases; volunteers with a history of surgery for less than one year, disc herniation and / or fractures in the spine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-84qkkv	Correlation of Genetic Characteristics with Development of Specific Diseases in Patients with Familial Adenomatous Polyposis	Recruitment completed	Intervention	2018-06-13	<NULL>	<NULL>	1887	Genotype-Phenotype Correlation in Patients with Familial Adenomatous Polyposis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Fundação Pio XII	Fundação Pio XII	https://ensaiosclinicos.gov.br/rg/RBR-84qkkv	<NULL>	Carriers of Classical Familial Adenomatous Polyposis Syndrome. Carriers of pathogenic germline variants in the APC gene.	"Familiar members tested to the  mutation in the APC gene not carrying APC gene-related mutation.
Patients carrying the mutation in the APC gene who are  not willing to undergo the protocol of screening tests for colonic and extra-colonic manifestations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-7x7fg2	Correlation of respiratory muscle training with the functional capacity and quality of life of patients with heart failure	Recruitment completed	Observational	2019-03-28	<NULL>	<NULL>	2553	Effects of respiratory muscle training on the functional capacity and quality of life of individuals with heart failure	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade de Franca	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-7x7fg2	<NULL>	Patients with Heart Failure of functional class III and IV; of both sexes; age between 57 and 80 years; with at least one year of outpatient follow-up with a cardiologist.	Participants with heart failure class I and II; those that are not released by medical evaluation; those who are in clinical follow-up with less than one year of follow-up by the doctor in charge; those with severe pulmonary limitation; those who do not want to participate in the study or leave without the conclusion of the study; those that obtain and exacerbate in the middle of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-86kpdr2	Correlationship between the timed inspiratory effort index and the value of the sequence of four stimulus during the recovery of neuromuscular blockade produced by the rocuronium in anestesia	Recruiting	Observational	2023-05-18	<NULL>	<NULL>	6092	Correlationship between the Timed Inspiratory Effort Index and the value of the Sequence of Four Stimulus during the recovery of neuromuscular blockade produced by the rocuronium in anestesia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Hospital Federal de Bonsucesso	Hospital Federal de Bonsucesso	https://ensaiosclinicos.gov.br/rg/RBR-86kpdr2	<NULL>	both genders; age between 18 and 65 years; physical status American Society of Anesthesiologists (ASA) I to III; patients who will undergo elective surgeries under general anesthesia who do not require a dose of rocuronium maintenance	refusal to participate in the study; pregnancy or suspected pregnancy; presence of neuromuscular diseases, renal dysfunction (assessed by calculating the glomerular filtration rate) or hepatic (CHILD criteria); history or predictors of difficult airway; use of furosemide, aminoglycosides, aminophylin, azathioprine; cyclophosphamide, anti-inflammatory drugs and magnesium; allergy to the drugs used in the study; participants in other clinical studies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-89w7hc2	Cortical activity assessment and the use of Virtual Reality for rehabilitation and cortical activity assessment in patients who had stroke episodes	Data analysis completed	Intervention	2024-08-26	<NULL>	<NULL>	7276	Cortical connectivity assessment and Virtual Reality intervention for rehabilitation of stroke patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Instituto de Física Gleb Whatagin	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-89w7hc2	<NULL>	Patients who suffered a stroke (type 1); patients who have hemeparesis as a consequence of the stroke; both female and male gender patients; patients above 18 years old	Patients who are confused and disoriented; patients who have comprehension aphasia; patients without any motor deficit; patients who have claustrophobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-5h8z7h	Cosmetic Acupuntura for reduction facial wrinkles	Data analysis completed	Intervention	2020-01-09	<NULL>	<NULL>	3345	"Acupuncture applied to facial aesthetics for
wrinkles of expression: clinical trial"	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-02-10	Cristiane Garcia sanchez	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5h8z7h	<NULL>	women; aged between 40 and 64 years; wrinkles  grade II or III by the Glogau scale.	facial esthetic surgery; application of Botox, laser in the last six months; lesions on the face, pregnant women, in use of anticoagulant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-3n5ckxn	Cosmetic product for treating cellulite with caffeine associated with ionic liquid	Data analysis completed	Intervention	2021-02-03	<NULL>	<NULL>	4500	Cosmetic Product for Treatment of Ginoid Hydrolipodystrophy with Caffeine Associated with Ionic Liquid	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-20	Universidade de Sorocaba	Universidade de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-3n5ckxn	<NULL>	being a healthy female, aged between 18 to 55 years old; without any skin problem, such as the presence of dermatitis or wounds.	the manifestation of any type of allergy or skin irritation by the applied product; history of allergic manifestations and lack of availability to attend the sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-9gghtb	Costs and benefits of papachia in pediatric dentistry: A randomized clinical trial	Data analysis completed	Intervention	2017-01-08	<NULL>	<NULL>	1135	Cost evaluation and comparison of the public health benefits of the atraumatic method of caries removal with papayar gel in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-10	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade de Cruz Alta	https://ensaiosclinicos.gov.br/rg/RBR-9gghtb	<NULL>	Children of both sexes, enrolled in the 1 year of Municipal Schools of the city of Ijuí of RS state that had carious lesions cavitated in deciduous or permanent molars	Children who did not have restorative needs, or had only dental caries lesions, or that the parents or guardians did not accept to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-4stzq4	Cough and diaphragmatic breathing exercise: is there airway repercussion in children with cystic fibrosis?	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2948	Long-term follow-up of the Cystic Fibrosis patient profile	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Hospital Infantil Joana de Gusmão	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4stzq4	<NULL>	Children between six and 15 years of age; clinically stable; with diagnosis of CF confirmed according to the Brazilian Guidelines for diagnosis and treatment of CF; no neurological deficit; no auditory deficit; no visual deficit.	Children who are unable to perform or terminate IOS will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-5dqvkv3	Could trained people have a better response of the defense mechanisms in the presence of the COVID-19 virus than sedentary people? A follow-up study to monitor the Immune System and Stiffness of the Arteries	Recruiting	Observational	2021-09-21	<NULL>	<NULL>	4907	Could physical fitness level modulate innate immune response and prevent Arterial Stiffening and Vascular Dysfunction in COVID-19 patients?A follow-up study for monitoring of Immune Function and Arterial Stifffness	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-05-15	Universidade Estadual Paulista Julio de Mesquita Filho	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dqvkv3	<NULL>	Patients with previous SARS-CoV-2 infection;  mild signs of COVID-19; show positive PCR test for covid 19;  both genders; aged between 20 and 40 years old.	presence of chronic non-communicable diseases; drug use; use of anti-inflammatory drugs; use of antibiotics; frequent alcohol consumers; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-7dj4mt3	Counseling and Physical Exercises: effects on the Health of pregnant women during prenatal care	Not yet recruiting	Intervention	2025-01-25	<NULL>	<NULL>	7682	Impact of Counseling and Physical Exercises on biomarkers and health indicators of pregnant women in prenatal care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Jataí	Secretária Municipal de Saúde de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-7dj4mt3	<NULL>	Pregnant women registered at the basic unit and undergoing prenatal care; have completed 12 weeks of pregnancy; are aged 18 or over; live in the municipality of Jataí-GO	Pregnant women with clinical comorbidities (hypertension and diabetes); multiple pregnancies; pregnant women with intellectual disabilities identified by a health professional, reported by a companion, or perceived when answering the study instruments; having self-reported or perceived motor limitations that do not allow them to perform motor and functional tests and physical exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-7xskj7	Counseling as a treatment for women with Depressive Symptoms in high-risk pregnancy	Recruiting	Intervention	2020-06-24	<NULL>	<NULL>	3945	Counseling therapeutic intervention for women with Depressive Symptoms in high-risk pregnancy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-10	Marlise de Oliveira Pimentel Lima	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xskj7	<NULL>	Be over 18 years old; be able to understand instructions and answer questions in Brazilian Portuguese; agree to participate in the research by signing the Informed Consent Form; being between 18 up to 26 weeks of gestation; having a diagnosis of any pathology that classifies pregnancy as a high-risk pregnancy.	Use of antidepressant or anxiolytic medication in the current pregnancy; being under psychiatric/psychological treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-45kf9p	CoV-Hep study : Comparative study between different anti-coagulation strategies in continuous hemodialysis in COVID-19 patients	Recruiting	Intervention	2020-07-13	<NULL>	<NULL>	4003	CoV-Hep study: Randomized and paired clinical trial comparing regional anticoagulation modalities in continuous venous venous hemodialysis in patients with COVID-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-29	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-45kf9p	<NULL>	"Men and women aged 18 and over;

Confirmed or probable SARS-CoV-2 infection;

Presence of acute kidney injury with indication and agreement between ICU and nephrology teams for the introduction of renal continuous venous venous hemodialysis."	"Hypersensitivity to any of the substances used in the study (Citric acid dextrosol 2.2% and unfractionated heparin);

Previous diagnosis of coagulopathy or thrombophilia;

Contraindication to the use of unfractionated heparin by the assistant team;

Risk of citrate poisoning - (Lactate&gt; 30mg / dL, IRN&gt; 2.5, Total bilirubin&gt; 15mg / dL);

Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-6gdmb8c	COVID-19 diagnostic and control methodologies based on artificial intelligence	Recruitment completed	Observational	2021-05-21	<NULL>	<NULL>	4667	Technological platforms for the diagnosis and control of COVID-19.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-04-20	Imunoscan Engenharia Molecular LTDA	Financiadora de Estudos e Projetos - FINEP	https://ensaiosclinicos.gov.br/rg/RBR-6gdmb8c	<NULL>	Health professionals; emergency care patients; patients admitted to the infirmary; intensive care unit patients; symptomatic or asymptomatic for COVID-19.	Volunteers without contact with COVID-19 virus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-5ty2pnv	COVID-19 Pandemic and Tuberculosis Control in the State of São Paulo: Monitoring by Telemonitoring	Not yet recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7256	Impact of COVID-19 on tuberculosis control in the state of São Paulo - Brazil: Analysis of morbidity and mortality indicators and coping strategies through digital health.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5ty2pnv	<NULL>	New cases of tuberculosis. Over 18 years old. No gender criteria. Own a smartphone (intervention group). Health professionals responsible for Directly Observed Treatment (DOT) and/or monitoring of people with tuberculosis. Unit managers (Primary Health Care (PHC) coordinators and/or tuberculosis program coordinators of the health units in the municipalities, previously selected)	Resistant Tuberculosis. Professionals and/or managers who have been in the position or working with tuberculosis for less than 6 months. Unavailability of individual or family cell phone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-3t9pkzt	Covidreab study: pulmonary rehabilitation on physical capacity, functional capacity, and quality of life in post-covid-19: randomized, controlled  double-blinded clinical trial	Not yet recruiting	Intervention	2021-07-01	<NULL>	<NULL>	4772	Covidreab study: pulmonary rehabilitation on physical capacity, functional capacity, and quality of life in post-covid-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3t9pkzt	<NULL>	Clinically stable individuals, residing in Manaus must have been diagnosed with COVID-19 by the polymerase chain reaction method (RT-PCR) for SARS-CoV-2, remained hospitalized and had discharged from the hospital. In addition, volunteers must present a pre-hospitalization medical history of clinical stability in the 4 months before hospitalization for COVID-19 and perception of dyspnea II and III by the Medical Research Council (MRC).	Volunteers undergoing pulmonary rehabilitation 6 months before the start of the study, pregnant women, previous medical history of respiratory diseases (COPD, asthma, idiopathic pulmonary fibrosis), arterial O2 saturation (SpO2) ≤ 88% at rest, hypertension uncontrolled, cardiovascular (heart failure, hypertension, transplantation, and surgeries), history of use and abuse of illicit drugs, alcoholics, smokers, pacemakers and/or implantable defibrillators, oncologic, metabolic (diabetes) and decompensated, chronic-degenerative kidneys in progression and osteoarticular and cognitive that prevent the performance of the physical exercise. In addition, individuals who present claustrophobia to the use of the NIV mask for training or performing the cardiopulmonary test will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-2bzdm3	Cow milk with higher concentration of Selenium and Vitamin E improves children&apos;s health	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1548	Effects of the inclusion of Sunflower Oil with addition of Selenium and Vitamin E in the diet of lactating cows on the production and milk composition and its influence on human nutrition	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Faculdade de Zootecnia e Engenharia de Alimentos	Agência Paulista de Tecnologia dos Agronegócios	https://ensaiosclinicos.gov.br/rg/RBR-2bzdm3	<NULL>	healthy volunteers; both genders; age between 8 and 10 years; did not use compulsory medication	volunteers aged less than 8 years and over 10 years; volunteers who stayed 2 consecutive days without receiving milk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-6gphkr	"CQAB149BAR01 - 24-week study to assess which treatment is safer and bring more benefits to patients with COPD (Chronic Obstructive Pulmonary Disease)
combination budesonide / indacaterol vs fluticasone /
salmeterol"	Recruiting	Intervention	2015-03-04	<NULL>	<NULL>	412	"CQAB149BAR01 - 24-week study to evaluate efficacy and safety of the
combination budesonide / indacaterol vs fluticasone /
salmeterol in patients with COPD"	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-02-28	Novartis Biociências S.A.	Novartis Biociências S.A.	https://ensaiosclinicos.gov.br/rg/RBR-6gphkr	<NULL>	Patients both genders, age greater than 40 years in outpatient treatment with a diagnosis of COPD in groups C and D, according to the GOLD with post-bronchodilator FEV1 &lt;60% guidelines and 30% predicted, FEV 1 / FVC post-bronchodilator &lt;0.7; smoking for at least 10 pack-years (defined as 20 cigarettes per day for 10 years or 10 cigarettes per day for 20 years and so on); smokers and ex-smokers are eligible; history of at least one exacerbation of COPD.	Patients requiring oxygen therapy for chronic hypoxemia (excluding acute exacerbation of COPD), typically with oxygen&gt; 15 h per day; COPD exacerbation within 6 weeks prior to visit 1 or between visits 1 and 2 or the presence of infection of the upper or lower respiratory tract infection during the screening period (Visit to 2) shall be permitted to a new screening after a minimum and 6 weeks after resolution of the episode; Pulmonary disease associated, for example, (except confirmed by chest radiography and no longer active) pulmonary tuberculosis or clinically significant bronchiectasis, sarcoidosis, interstitial lung disease or pulmonary hypertension; known diagnosis of deficiency of Alpha-1 Antitrypsin; Pulmonary lobectomy; lung volume reduction or lung transplantation; participation in the active phase of a program of supervised pulmonary rehabilitation; Asthma history marked by (but not limited to):.. onset of respiratory symptoms (coughing, wheezing, shortness of breath) suggestive of asthma before age 40 and history of a diagnosis of asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-7n2d2f	Cranial electrical current associated with gait training on a treadmill in people who have had a stroke.	Recruiting	Intervention	2015-03-04	<NULL>	<NULL>	413	Transcranial direct-current stimulation combined with treamill training for Stroke:a randomized, controlled, duble-blind, clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Conselho Nascionla de Pesquisa (CNPq)	Conselho Nascionla de Pesquisa (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-7n2d2f	<NULL>	Patients with a diagnosis of stroke. Both sexes. Age between 50 and 70 years. Able to walk independently.	Patients with stroke who have joint pain in the lower limbs that compromise the function. What have contractions in the joints of the lower limbs. With cardiovascular and cognitive changes that make it impossible to perform the tests. With metal implants in the head.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-55vv9b2	Creatine intake in hemodialysis patients	Recruitment completed	Intervention	2022-08-18	<NULL>	<NULL>	5562	Evaluation of creatine supplementation in renal hemodialysis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade de Medicina	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-55vv9b2	<NULL>	chronic kidney disease; both genders; age between 18 to 60 years; hemodialysis treatment	Diagnosis of impaired cognitive function; communication difficulties; hearing deficiency; amputations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-3vh8zgj	Creatine supplementation plus resistance training in adults	Data analysis completed	Intervention	2022-10-14	<NULL>	<NULL>	5663	Effect of Creatine Monohydrate Supplementation in association with Strength Training with Blood Flow Restriction on strength and muscle mass gain in untrained men	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3vh8zgj	<NULL>	Male participants between eighteen and thirty years of age	Volunteers who have a body mass index below eighteen and above twenty-four; or those who, of their own free will, no longer want to participate in the study; do not attend training and collection sites on scheduled days; Have participated in strength training in the past six months; having used a food supplement or ergogenic medication for at least two years before the study; smoking or drinking alcohol at least a week before tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-5424gfp	Creatine Supplementation Safety for Older Woman	Terminated	Intervention	2022-06-28	<NULL>	<NULL>	5450	Creatine Supplementation Safety for Olders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-05	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-5424gfp	<NULL>	Be physically active for at least 6 months. Do not use psychoactive medications.	Having suffered an injury or fall in the last 2 months; cognitive difficult; advanced-stage neurodegenerative diseases; Have sequelae of a stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-3v6pmy	Creating a new program of exercise for heart disease	Recruitment completed	Intervention	2016-07-12	<NULL>	<NULL>	920	Creation of a new method of exercise prescription for phase II of the cardiac rehabilitationprogram   for patients with coronary artery disease (first protocol)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Pontificia Universidade Catolica do Paraná	Hospital cardiológico costantini	https://ensaiosclinicos.gov.br/rg/RBR-3v6pmy	<NULL>	coronariophatic patients with ischemic scintigraphy; transluminal coronary angioplasty; acute myocardial postinfarction; with left ventricular ejection fraction &lt; 50% (assessed by transthoracic echocardiography) and stratified as low or moderate risk for the practical exercises according to AACRP.	muscle or osteoarticulars lesions induzed by exercise; failure to comply with the 36 sessions of the program or cardiovascular events that prevented the permanence in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-3zj4hgf	Creation of a medication delivery model to improve the treatment of patients with Mental Illness	Recruitment completed	Intervention	2023-02-06	<NULL>	<NULL>	5875	Development of a medication dispensing model to improve the degree of adherence in Psychiatric Patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3zj4hgf	<NULL>	individuals aged 18 years or older; active medical record in the health unit under study; diagnosis of mental disorder in pharmacological treatment; ability to self-administer their medications, being self-declared by the patient	individuals who were unable to understand and answer the questions of the instruments used for data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-79ttm4m	Creation of an assessment score for small, medium and large joints, through joint ultrasound examination in patients with rheumatoid arthritis	Recruitment completed	Observational	2021-12-13	<NULL>	<NULL>	5103	Joint ultrasound in patients with rheumatoid arthritis: development of an evaluation score using small, medium and large joints.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-79ttm4m	<NULL>	Rheumatoid arthritis for more than 1 year, according to the ACR criteria (Arnett, Edworthy et al. 1988); Age between 30 and 60 years, stratified in the following age groups: 30 to 39 years: 33.3%, 40 to 49 years: 33.3% and 50 to 60 years: 33.3%; Female and male sex, in the proportion of three women for each man; Have accepted to participate in the previous study and signed the free and informed consent form for the study from which we used the data.	"Diagnosis of diabetes mellitus; Diagnosis of hypothyroidism; Diagnosis of hemophilia; Suspected pregnancy, current pregnancy or until the 6th month of postpartum; Women in active lactation; History of trauma in the studied joints; History of septic arthritis in the joints studied.
History of surgery on the joints studied.
Symptomatic osteoarthritis in the studied joints.
Severe joint deformities.
Overlap with another collagen.
Corticosteroid infiltration in any joint to be studied for less than 6 months.
Corticosteroid infiltration into any joint that has not been studied for less than 1 month."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-9jgz9d	Creation of reminders to improve nurses&apos; practice regarding registration and use of the child&apos;s book	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1779	Behavioral technology for nurses to enroll and use the child&apos;s book	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Estadual do Ceara	Universidade Estadual do Ceara	https://ensaiosclinicos.gov.br/rg/RBR-9jgz9d	<NULL>	Work on family health strategies that perform child care, work on family health strategies that are located in the urban and rural areas of the municipality of barro	Medical license, physical or mental condition that makes it impossible to participate in the research periodo	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-7xv3cdz	CRISCO study: lifestyle and health of adolescents from the Federal District	Recruiting	Observational	2025-10-31	<NULL>	<NULL>	8475	CRISCO study: health risk behaviors in adolescents in the Federal District	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Programa de Pós-graduação Stricto Sensu em Educação Física da Universidade Católica de Brasília - PPGEF-UCB	<NULL>	<NULL>	<NULL>	Students of both sexes; aged between 14 and 19 years; regularly enrolled in the integrated technical high school programs at the Federal Institute of Brasília (IFB); presentation of the Informed Consent Form signed by parents or guardians for those under 18 years old, or by the adolescents themselves for those aged 18 or 19; and presentation of the Assent Form signed by adolescents under 18 years old	Physical and/or mental conditions that compromise safe participation, such as inability to understand or respond to questionnaires, severely reduced mobility; pregnant adolescents; absence on assessment days (resulting in incomplete data); and voluntary withdrawal	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:27
RBR-6p3g8m3	CRONOEX: how the time of day when physical exercise is performed influences brain function and blood glucose control in people with type 2 Diabetes	Recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8619	CRONOEX: impact of exercise and physical training timing on cognitive, neurofunctional, and circadian responses in type 2 Diabetes: from molecular mechanisms to clinical management	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Both genders; medical diagnosis of type 2 Diabetes (minimum 5 years); age 55-75 years; not participating in regular physical exercise programs; not being a smoker; absence of complications caused by the disease such as retinopathy, coronary artery disease, autonomic neuropathy or uncontrolled systemic arterial hypertension; (viii) obtaining a score &gt; 19 and &lt; 27 on the Montreal Cognitive Assessment.	Failure to participate in one of the assessment procedures; any orthopedic injury or other condition that makes it impossible to carry out the exercise sessions proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-64fx6x	Cross-Education in People with Parkinson’s Disease, a Short-Term Randomized Controlled Trial	Data analysis completed	Intervention	2018-12-01	<NULL>	<NULL>	2355	Effects of unilateral and bilateral training methods on motor control and strength in individuals with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-21	Universidade de Brasília	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-64fx6x	<NULL>	"Clinical diagnosis of PD by neurologist or physician according to the United Kingdom Parkinson&apos;s Disease Society Brain Bank criteria;
Modified Hoehn and Yahr Scale classification between stages 1 and 3;
No cognitive impairment as assessed by the Mini Mental State Examination (MMSE). The cut-off points for inclusion were &gt; 24 points for literate individuals and &gt; 19 for non-literate individuals;
Controlled hypertension (&lt;150/90 mmHg);
Do not have extreme obesity (&gt;40 Kg/m2);
Do not have a heart pacemaker;
Do not have amputation of upper or lower limbs;
Male and female volunteers from the Federal District;
Individuals between 40 and 80 years who do not have health problems and / or disabilities that prevent them from completing the test batteries and training program or who may have their problems aggravated due to participation in the program;
Availability to participate on activities proposed by researcher;
Have not practiced vigorous exercise at least 6 months previous."	"Any kind of trauma that prevents participation in the study;
Inability to perform any of the tests that are part of the research study;
Individuals who may voluntarily want to stop their participation in research; 
Individuals who do not have availability to participate in the research activities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-368y8pw	Cross-sectional study of non-classical B cell signatures in Brazilian patients with Crohn’s Disease	Recruiting	Observational	2026-03-03	<NULL>	<NULL>	8933	Analysis of intestinal mucosa and fat nearby the intestine in patients with Crohn&apos;s disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-10-25	Hospital de Clínicas - Universidade Estadual de Campinas (UNICAMP)	<NULL>	<NULL>	<NULL>	Patients with endoscopic and histological diagnosis of ileocecal Crohn&apos;s disease undergoing surgical procedure, both genders. For the control group of distal ileum, patients who underwent colonoscopy for other reasons, whose examination comes without endoscopic changes. For the control group of mesenteric adipose tissue (intestinal fat), patients with non-inflammatory diseases of the left colon undergoing surgery, with normal terminal ileum. All survey participants are over 18 years of age	The patients participating in the control groups without the use of medication. And Crohn&apos;s patients with disease locations other than the small intestine	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-6qvdftm	Crowns on ceramic implant with experimental glass: study of its clinical behavior	Recruiting	Intervention	2023-05-02	<NULL>	<NULL>	6044	Clinical influence of functional gradation with glass on implant-supported zirconia crowns: evaluation of wear, color stability and degradation at low temperature	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-21	Universidade Federal do Rio de Janeiro	Instituto de Ciência e Tecnologia de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-6qvdftm	<NULL>	Patients between 18 and 70 years of age, of both sexes; Patients who are missing 1, up to 2 molars and/or premolars with an indication of receiving osseointegrated implants;The opposing tooth must be sound or with a small restoration (occlusal isthmus of a maximum occlusal 1/3); There must be the presence of collateral teeth to the implant without proximal restorations; Signing of the Free and Informed Consent Term (TCLE) for participating in the research, after explaining the risks and benefits (Resolution No. 196 of October 1996 and the Dental Professional Code of Ethics – C.F.O. - 179/93)	Severe periodontal disease, caries disease and poor oral hygiene; Patient without antagonist tooth or with removable prostheses; Patient with the opposing tooth to the restored implant; Missing posterior tooth; Patient with comorbidities that contraindicate implant surgery; Pregnant and lactating patients; Patients who make continuous use of corticoid anti-inflammatory drugs; Antibiotic therapy in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-8pxcth	Crr: Cardiac Resuscitation Project	Recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3277	RCR Project - Prototype for Basic Life Support	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8pxcth	<NULL>	Young people between 18 and 40 years old; healthy; know how to apply cardiac massage; belong to healthcare	Not knowledge of the technique; upper limb orthopedic disease; upper limb pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-4sxpff	CTT116855 Twelve month study to compare three investigational medications in patients with chronic obstructive pulmonary disease who have a history of COPD exacerbation	Recruitment completed	Intervention	2016-07-05	<NULL>	<NULL>	919	CTT116855 A phase III, 52 week, randomized, double-blind, 3-arm parallel group study, comparing the efficacy, safety and tolerability of the fixed dose triple combination FF/UMEC/VI with the fixed dose dual combinations of FF/VI and UMEC/VI, all administered once-daily in the morning via a dry powder inhaler in subjects with chronic obstructive pulmonary disease	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2014-06-30	GlaxoSmithKline	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-4sxpff	<NULL>	Subjects with at least 40 years old with history of cronic obstructive pulmonary disease and also smoking history; that is currently receiving cronic treatment for cronic obstructive pulmonary disease and have history of exacerbations	Pregnancy or lactating women; subjects with asthma diagnostics or other respiratory disorders; hepatic unstable  disease or cardiopaty unstrable; others	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-9xtq9p6	CuidAR: reducing hospitalizations and costs with Asthma in Brazil	Not yet recruiting	Intervention	2023-01-16	<NULL>	<NULL>	5827	CuidAR: reducing morbidity and costs in Asthma in the country	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-15	Associação Hospitalar Moinhos de Vento	Associação Hospitalar Moinhos de Vento	https://ensaiosclinicos.gov.br/rg/RBR-9xtq9p6	<NULL>	Participants of both sexes, aged between ≥6 and ≤65 years at the time of study entry; Medical diagnosis of asthma; Asthma Control Test or Childhood Asthma Control Test with a score &lt; 20; Previous history of two or more episodes of exacerbation; use of bronchodilators and systemic corticosteroids in the last 12 months; Possibility of access by the study team through the patient&apos;s personal phone and/or guardians; Patient followed up for at least 3 months in the basic health unit.	Absence of consent to participate in the study by the guardian and/or participant; Patients diagnosed with chronic obstructive pulmonary disease, defined as dyspnea accompanied by chronic cough with or without sputum, recurrent respiratory infections and spirometry with an forced expiratory volume in one second/forced vital capacity index &lt;0.7 after bronchodilator administration; Major smoking history (&gt; 20 years of smoking or &gt; 10 packs/year); Pregnant women, breastfeeding and/or planned pregnancy during the study period; Hospitalization for asthma in the last 30 days; Cognitive impairment and other conditions that may affect asthma treatment or study adherence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-46kbnp	Cupping in patients with neck pain.	Not yet recruiting	Intervention	2018-02-26	<NULL>	<NULL>	1657	Effects of cupping therapy on myofascial trigger points in the upper trapezius muscle of patients with chronic neck pain.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-30	Departamento de Ciências da Saúde e Biológicas da Universidade Federal do Amapá	Departamento de Ciências da Saúde e Biológicas da Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-46kbnp	<NULL>	"Neck Disability Index (NDI) score&gt;5 points and punctuation on the Numeric Rating Scale (NRS) &gt; 3;
Present bilateral and active trigger point, centrally located in the trapezius muscle descendent fibers."	The exclusion criteria adopted in the present study will be individuals with a history of cervical trauma; head, face or cervical surgery; cervical hernia; degenerative diseases of the spine; have undergone physiotherapeutic treatment in the last three months; use of analgesic, anti-inflammatory or muscle relaxants in the last week; presence of systemic diseases; medical diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-3578vwr	Cupping therapy for neck pain and disability	Recruiting	Intervention	2023-11-04	<NULL>	<NULL>	7368	Cupping therapy for neck pain and disability	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-06	Universidade Federal de Pernambuco	Departamento de Fisioterapia da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3578vwr	<NULL>	Visual Analogue Scale (VAS) greater than or equal to 3 points; Neck Disability Index (NDI) greater than or equal to 13 points	Pregnant or lactating women; patients who use anticoagulants; anemia; use of opioid analgesics (examples: Morphine, Tramadol, Hydromorphone, Fentanyl, and others) at the time of data collection or up to three months prior; patients presenting red flags (vertebral fracture, vertebral tumor, vertebral infection; systemic diseases (autoimmune, infectious, vascular insufficiency, renal insufficiency, hepatic insufficiency, neoplasia); fibromyalgia; cervical disc herniation; previous spine surgery; patients with open or poorly healing wounds in the cervical region; cervical brachialgia; alteration of skin integrity and people who have been previously treated with cupping therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-7rppdgs	Cupping Therapy in Fibromyalgia	Recruitment completed	Intervention	2023-09-21	<NULL>	<NULL>	6456	Effect of Cupping Therapy on flexibility, functionality, pain and quality of life in Fibromyalgia Patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Adriana Teresa Silva	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7rppdgs	<NULL>	Age between 30 and 65 years old; female and presenting the clinical diagnosis with fibromyalgia syndrome;; for more than three consecutive months; which was based on the diagnostic criteria of the American College of Rheumatology (2010); accept to participate and sign the Informed Consent Term (TCLE)	Patients who had dermatological disorders at the application site; presence of deep venous thrombosis;  presence of central and peripheral nervous system injury; orthopedic surgeries performed at the application site and did not accept signing the TLCE were excluded from the present study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-9fjfnh	Curcuma longa (Tumeric) as an auxiliary treatment for Idiopathic Childhood Nephrotic Syndrome	Recruiting	Intervention	2018-01-02	<NULL>	<NULL>	1542	Curcuma longa as adjuvant in the treatment of Idiopathic Childhood Nephrotic Syndrome	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9fjfnh	<NULL>	The study will include all patients older than one year; who have the diagnosis of idiopathic childhood nephrotic syndrome; who are followed up at the Childhood Nephrology Clinic of the Clinics Hospital of Ribeirão Preto of the University of São Paulo,  (i.e. ANEI); and whose parents or legal guardians authorize participation through signature of informed consent.	Will not be included in the project those patients younger than one year; those with nephritic syndrome characteristics; with another etiology for the nephrotic syndrome, as secondary causes (e.g. IgA nephropathy, membranoproliferative glomerulonephritis, systemic lupus erythematosus and secondary to Infectious diseases); or whose parents or legal guardians disagree with their participation in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-9p8jnf9	Curcumin and women’s health: investigating its effects in women with overweight and polycystic ovary syndrome	Recruitment completed	Intervention	2025-12-02	<NULL>	<NULL>	8608	Effects of curcumin supplementation on metabolic parameters in overweight and obese women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-02	Centro de Saúde Escola da Faculdade de Medicina de Ribeirão Preto - USP	<NULL>	<NULL>	<NULL>	The sample consisted of women diagnosed with polycystic ovary syndrome who met the inclusion criteria which are women aged between 18 and 40 years; women classified as overweight and obesity grade I and II with body mass index greater than or equal to 25 kilograms per square meter and less than or equal to 39.9 kilograms per square meter	Participants were excluded from the study if they reported an allergy to curcumin or its derivatives, or presented with any of the following conditions pregnancy or breastfeeding period; late-onset congenital adrenal hyperplasia; androgen-secreting tumors; thyroid dysfunction; hyperprolactinemia; cushing&apos;s syndrome; ovarian insufficiency; hypothalamic amenorrhea; chronic kidney disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-6sf2vv	Custom-made articulated ankle-foot Orthoses associated with home-based mobility tasks improve functional mobility and autonomy compared with fixed Orthoses in patients with Stroke: A Randomized Clinical Trial	Terminated	Intervention	2018-03-05	<NULL>	<NULL>	6758	Influence of the Ankle-foot Orthosis on the motor function and gait of patients after Ischemic Stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-04	Faculdade de Medicina Botucatu	Faculdade de Medicina Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6sf2vv	<NULL>	Individuals who can use both types of orthoses in the treatment; who suffered an ischemic stroke within one year; both genders; who have a previous Rank less than or equal to 3; who are able to walk with or without a walking aid for five uninterrupted minutes; who received the orthosis through the rehabilitation clinic of the Hospital das Clínicas, Faculdade de Medicina de Botucatu	Lower limb amputation; non-ambulatory patients (Rankin 4 and 5); blindness; severe motor aphasia; late phase of stroke (after 12 months) and patients with progressive neuromuscular diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-2nn9y2	Cutaneous analysis after cells from adipose tissue  applied  in human face	Recruitment completed	Intervention	2017-05-06	<NULL>	<NULL>	1226	Cutaneous analysis after adipose mesenchyimal cells from stromal vascular fraction applied in human face	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2012-08-01	universidade federal do rio de janeiro	universidade federal do rio de janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2nn9y2	<NULL>	20 Healthy patients of both genders, presenting photaged; candidates for facial rejuvenation surgery (face lift); without any clinical procedure in face: laser resurfacing; using PMNA and others;  age rande between  45 and 65 years	"patients with coexisting base disease, such as type II diabetes and other metabolic diseases and autoimmune diseases;
Patients smokers;
 Patients with umbilical hernia;
 Patients with infective dermatitis Local;
 Patients with autoimmune diseases and hematological abnormalities;
 Patients undergoing chemotherapy and / or radiotherapy prior chronic use of corticosteroids and connective tissue diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-83y3x8b	Cycles Associated with Executive Functions (CAFE): proposal for a speech therapy model for children with speech sound exchange problems	Terminated	Intervention	2026-03-05	<NULL>	<NULL>	8948	Phonological Disorder: application of therapy models	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-25	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Children aged between six and eight; both sexes; diagnosed with Phonological Disorder - PD with medium-moderate or moderate-severe degrees of severity; that did not present expressive phonetic changes or did not present phonetic distortions in non-acquired phonemes; and who had not undergone (or were undergoing) speech therapy	Children whose guardians did not sign the Informed Consent Form (TCLE) or requested exclusion from the research; who did not agree to the Assent Form (TA) and who did not present a diagnosis of Phonological Disorder - PD or who presented a Phonological Disorder with a medium or severe degree of severity; with hearing loss; with evident neurological changes, with impairment of intellectual abilities; with expressive phonetic changes or that presented phonetic distortions in non-acquired phonemes; unable to understand speech and/or with expressive language changes in linguistic domains (in addition to phonology)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-57z7gz	Daily contractions induced by transcutaneous electrostimulation modify clinical and functional outcomes in critically ill patients	Not yet recruiting	Intervention	2020-08-12	<NULL>	<NULL>	4115	Daily contractions induced by transcutaneous electrostimulation modify clinical and functional outcomes in critically ill patients: clinical, randomized, double-blind, controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-15	Luciana Mara Meireles Aguiar Pereira	Luciana Mara Meireles Aguiar Pereira	https://ensaiosclinicos.gov.br/rg/RBR-57z7gz	<NULL>	Patients over 18 years old admitted to the intensive care unit; both genders, on mechanical ventilation; who walked at least 10 meters before hospitalization.	Neuromuscular diseases; lower limb amputation; pregnancy; body mass index above 40 kg / m2; presence of external fixator or metal implants in lower limbs; open ulcers or skin lesions; pacemaker; rhabdomyolysis or creatinophosphokinase dosage above 4000 ui; cardiorespiratory arrest; spinal cord injury, stroke or head trauma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-8nx9n4d	Daily Diabetes program	Recruiting	Intervention	2023-06-13	<NULL>	<NULL>	6147	Educational program for self-management in type 2 diabetes Diabetes em dia (Dia D program): study to assess acceptability and feasibility	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-20	Universidade Paulista - UNIP	Universidade Paulista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-8nx9n4d	<NULL>	adults over the age of 18 with a medical diagnosis of type 2 diabetes who have not received a structured diabetes education for at least one year; with access to digital communication platforms and digital proficiency	pregnant women; people with cognitive or functional limitations that make difficult to make lifestyle modifications (eg, with severe depression, kidney failure, diabetic retinopathy, and neuropathy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-8g2rjk	Daily Oral Hygiene in Inpatients in Cardiology Unit	Not yet recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1893	Daily Oral Hygiene in Inpatients in Cardiology Unit: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8g2rjk	<NULL>	Be waiting for cardiac surgery; 40 years or older at the time of data collection; Be hospitalized more than one day at the cardiology unit; Be in good physical and mental condition to perform intraoral clinical examination	Use of immunosuppressive drugs or antibiotics; Have contraindications for treatment of another disease; Have had radiotherapy treatment near the head and neck region; Patients with a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-4733xbn	Daily pause from sedation in very ill children	Recruitment completed	Intervention	2024-08-21	<NULL>	<NULL>	7248	Daily interruption of sedation in children critically sick	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Complexo Hospital de Clínicas Universidade Federal do Paraná	Hospital Universitário Evangélico Mackenzie	https://ensaiosclinicos.gov.br/rg/RBR-4733xbn	<NULL>	Children between zero and eighteen years old; admitted to the pediatric intensive care unit; invasive mechanical ventilation; use of continuous sedative and analgesic medications for at least two days; guardian signs the free and informed consent form	Patients diagnosed with intracranial hypertension; Patients who require neuromuscular blocker for more than two days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7m82zcf	DAMA: Device for assessing the walking of people Post-Stroke	Recruiting	Observational	2025-02-17	<NULL>	<NULL>	7760	DAMA:  Portable device for kinematic Assessment of Gait in Post-Stroke individuals	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal do Rio Grande do Norte	Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7m82zcf	<NULL>	For individuals without a stroke - individuals who do not have any neurological, orthopedic or rheumatological condition that affects walking; of both genders; aged between 20 and 70 years. For individuals with stroke - have a diagnosis of stroke; of any etiology; at any stage of this condition (acute, subacute or chronic); be able to walk independently indoors - Functional Ambulation Category - FAC scores equal to or greater than 3; who do not use a walking aid; who do not have unstable heart conditions - New York Heart Association (NYHA) scores equal to or greater than 3; who do not have a clinical condition other than stroke that affects walking; of either gender; aged between 20 and 70 years old	Participants who for any reason feel unable to complete the evaluation protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-8kkh26	Dance Program for Older Adults	Not yet recruiting	Intervention	2019-01-03	<NULL>	<NULL>	2578	Effects of Dancing on Physical-Functional Fitness, Cardiometabolic Profile, Cognition and Quality of Life of Older Adults: a Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Hospital Universitário Onofre Lopes – HUOL	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-8kkh26	<NULL>	Both sexes; age equal or superior to 60 years; fit for physical exercise; pharmacological plan unchanged in the last 4 weeks; agreeing to participate in any of the groups; not participating in a regular exercise program in the last 3 months	Not signing the consent term; history of cardiovascular diseases or events; limiting chronic lung disease; chronic kidney disease requiring dialysis; uncontrolled hypertension; diabetes in use of insulin or decompensated; high alcohol consumption; uncorrected limitations of language, hearing or sight; contraindication for exercise, shown in the cardiopulmonary exercise test; cognitive impairment according to the MEEM and/or RAVLT tests; progressive neurological disorders; cancer requiring treatment in the last two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-4k44npd	Dance therapy benefits to older people	Recruiting	Intervention	2022-05-04	<NULL>	<NULL>	5377	Dance movement therapy contributions to the health and quality of life of elderly people at risk of functional decline	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-08	Universidade de Cruz Alta	Universidade regional do noroeste do estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4k44npd	<NULL>	Elderly people included in the Viver 60+ project (screening project for functional decline of users of UNIMED Planalto Centro in partnership with Unicruz). Being a resident of Cruz Alta. Show signs of functional decline. Have been submitted to the pre-test evaluations of the project.	Elderly people who do not accept to participate in the program and those who have medical contraindications or who do not participate in at least 25% of the proposed sessions within the three-month period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-4tbgv6	DASH diet (Dietary Approaches to Stop Hypertension) for pregnant women with diabetes and the effects of diet on the health of mother and son	Recruiting	Intervention	2016-05-27	<NULL>	<NULL>	4295	"DASH diet (Dietary Approaches to Stop Hypertension) Effect on Perinatal Outcome
Pregnant Women with Diabetes Mellitus"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-05	Universidade Federal do Rio de Janeiro - UFRJ	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-4tbgv6	<NULL>	Pregnant adults, diagnosis of diabetes mellitus ( types 1 and 2 ) of singleton pregnancy; non-smokers and non-users of alcohol; gestational age up to 28 weeks.	Pregnant women with chronic comorbidities such as kidney or liver disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-58jj2j	Data collection of patients with diagnostic of T-cell Lymphoma in the five regions in Brazil	Recruiting	Observational	2018-02-05	<NULL>	<NULL>	1630	T-cell Brazil Project: prospective collection of data in patients with T-cell Lymphomas distributed in the five distinct macro regions in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Hospital Samaritano de Sao Paulo Ltda	GEMOH- Grupo de estudos multicentricos em onco-hematologia	https://ensaiosclinicos.gov.br/rg/RBR-58jj2j	<NULL>	Date of diagnosis from January, 2015, Newly diagnosed patients with T-cell or T/NK cell peripherical lymphomas; tissue biopsies adequate for diagnosis and classification, all available for centralizes review; clinical data including baseline information on disease localization and laboratory parameters at staging, features on treatment adopted and assurance of follow up updating for at least 5 years are requested. Besides that, dated and signed consent form.	If diagnosis of Blastic NK-cell leukemia/lymphoma; Aggressive NK-cell leukemia; T-cell large granular lymphocytic leukemia; T-cell large granular lymphocytic proliferation; NK-cell large granular lymphocytic proliferation; T-cell prolymphocytic leukemia; Precursor T-cell lymphoblastic leukemia/lymphoma; mycosis fungoides; sézary syndrome; primary cutaneous ALCL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-38zssz	Daylight photodynamic therapy application in the treatment of a superficial skin carcinoma	Recruiting	Intervention	2016-08-24	<NULL>	<NULL>	971	Daylight photodynamic therapy application in the treatment of Bowen&apos;s disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-13	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-38zssz	<NULL>	Patients with clinical and histological diagnosis of Bowen´s disease at the Department of Dermatology of the Hospital de Clínicas de Porto Alegre.	Patients with allergy to medications under treatment; porphyria; pregnancy; lactation; lesions in area of difficult sun exposure; lesions with clinically-suggested invasive carcinoma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-9szgmpp	Deep Heat Application in Women with Fibromyalgia	Not yet recruiting	Intervention	2022-07-04	<NULL>	<NULL>	5461	The effects of Radiofrequency in patients with Fibromyalgia: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Instituto de Neurologia, Neurocirurgia e Comportamento	Universidade Federal do Amazonas - Instituto de Saúde e Biotecnologia	https://ensaiosclinicos.gov.br/rg/RBR-9szgmpp	<NULL>	Women; over 18 years of age; with fibromyalgia; one year of diagnosis; accepted to participate in the intervention	Women with metallic implants at the application site; with sensitivity alterations at the application site; with silicone prostheses; with a cardiac pacemaker; with neoplasms; with acute inflammatory processes; who are pregnant; with ischemic tissues; with tuberculous lesions; who have had recent deep vein thrombosis; with hemorrhagic conditions or the likelihood of this occurring; with heart disease; with decompensated blood pressure; who have attendance lower than 75% at the appointments/treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-9vv26mh	Deep Transverse Massage as a Potentiating Resource in the Treatment of Patellofemoral Pain Syndrome	Not yet recruiting	Intervention	2022-03-02	<NULL>	<NULL>	5251	Effectiveness of a Protocol Involving Deep Transverse Massage in the Treatment of Patellofemoral Pain Syndrome: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-09	Ingrid Fernanda Andrade Dias	Faculdades Nova Esperança	https://ensaiosclinicos.gov.br/rg/RBR-9vv26mh	<NULL>	Adults between 20 and 40 years of age; Those with anterior or retropatellar pain in the knee; Physical activity practitioners; Presence of weakness of the muscles of the quadriceps, abductors and external hip rotators	Knee joint surgery; Presence of clinical diagnosis related to the knee (MRI findings of intra-articular pathological conditions involving ligaments or meniscal effusion, subluxation or patellar dislocation); Fracture of the patella or in the knee region; Use of anti-inflammatory drugs; Presence of comorbidities (neoplasms, obesity, neurological diseases, cardiovascular disease and respiratory diseases); Physical therapy at another service	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-6dmh7d	Deep Water Running in reducing body weight, improved functional capacity and quality of life in obese	Recruiting	Intervention	2016-07-27	<NULL>	<NULL>	939	Effect of Deep Water Running in body composition, functional capacity and quality of life in pre-obese and obese adults: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-30	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-6dmh7d	<NULL>	Volunteers of both sexes; adults in the age group of 39 to 59 years of age; classified as pre-obese  and obesity I  according to the III Brazilian Guidelines on Obesity. Show good adaptation to the liquid medium; perform the entry; exit and walking in the pool independently, and adequately perform the Deep Water Running technique in interval training system (DWR-STI). All volunteers must submit prescription attesting to the absence of restrictive heart disease the practice of aquatic physical training.	"cardiorespiratory, musculoskeletal and neuromuscular diseases that impede the realization of the aquatic training program; as well as the following contraindications of aquatic physical therapy; hydrophobia; skin wounds and infectious diseases.
Volunteers may not have taken part in other physical training program for at least two months before the start of data collection, as well as carrying out other training or nutritional monitoring program for the aquatic intervention.
For those who use antihypertensive medications and therapy for hormone replacement therapy (HRT); will not be allowed to change in class and or drug dose. Each volunteer can have a maximum of 3 absences (10%) nonconsecutive during the intervention."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-6rzhnh	Defense mechanisms evaluation in abstinent smokers	Data analysis completed	Intervention	2013-12-18	<NULL>	<NULL>	269	Participation of Th1/Th2 cytokines and mucociliary clearance in current and abstinent smokers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-08	Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista Júlio de Mesquita Filho	Departamento de Fisioterapia da Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6rzhnh	<NULL>	Smokers with at least 20 years of smoking; both sexes; apparently healthy; enrolled in the Smoking Cessation Programme from Faculty of Sciences and Technology of São Paulo State University	Diagnosis cystic fibrosis, bronchiectasis, immotile cilia syndrome, chronic obstructive pulmonary disease, smoking-related diseases, history of nasal surgery or trauma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-3rnskcj	Deferoxamine to treat Iron Overload in patients on Dialysis: effect on bone, myocardial and liver	Data analysis completed	Intervention	2023-12-11	<NULL>	<NULL>	6646	Use of Deferoxamine in the treatment of Iron Overload in patients on Dialysis: impact on bone remodeling, myocardial function and liver storage	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Hospital das Clinicas da Universidade de Sao Paulo	Hospital das Clinicas da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3rnskcj	<NULL>	Adult patient on maintenance hemodialysisl; serum ferritin higher than 1000 ng/ml	Active smoking; Active use of alcohol; Previous use of desferoxamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-7vr7xs	Definition of a standard length of nasogastric feeding tube in adults: randomized clinical trial	Recruitment completed	Intervention	2015-02-26	<NULL>	<NULL>	407	Definition of a standard length of nasogastric tube in adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-06	Hospital das Clínicas da Unicamp	Faculdade de Enfermagem - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7vr7xs	<NULL>	Adult patients; with aged over 18 years; of both sexes; with medical prescription of nasogastric feeding tube.	Are excluded from the study patients with prescribed nasogastric tube for drainage, with mechanical obstruction of the Digestive System and morphological abnormalities of the gastrointestinal tract, with prior gastric surgery, morbidly obese, with diseases that may alter the external abdominal anthropometric measures. It will be considered an absolute contraindication for the introduction of nasogastric tube, patients who experience recent nasal surgery, coagulation disorders, esophageal varices, cauterization or recent ligation of esophageal varices, alkaline intake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-35q7s3v	Degradation rate of bleaching gels during in-office tooth bleaching	Other	Intervention	2023-05-16	<NULL>	<NULL>	7154	Clinical degradation rate of bleaching gels with different acidities during in-office tooth bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-35q7s3v	<NULL>	Patients aged 18 years or older; male or female; in good general and oral health; the premolars, canines and incisors of the maxilla and mandible they need to be free of caries lesions, restorations or endodontic treatments; the canines superiors must present WId values ​​lower than 20, evaluated with a digital spectrometer (Vita Easyshade, Vita Zahnfabrik, Bad Säckingen, Germany)	Pregnant or lactating patients; smokers; with bruxism; severe internal discoloration (tetracycline stains, fluorosis, teeth pulped); dentine hypersensitivity; gingival recession or undergoing orthodontic treatment; participants who use anti-inflammatories, analgesics or antioxidants daily; patients who have already undergone tooth whitening procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-3y869j	Delay in surgery following neoadjuvant chemotherapy in advanced ovarian cancer	Recruiting	Intervention	2019-12-06	<NULL>	<NULL>	3257	Retarded surgery following neoadjuvant chemotherapy in advanced ovarian cancer	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2019-09-26	Vanessa da Costa Miranda	Instituto do Cancer do Estado de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3y869j	<NULL>	"A subject will be considered eligible for inclusion in this study if all the following criteria are met: Female patients more than 18 years;
histologically confirmed epithelial ovarian cancer, fallopian tube carcinoma or primary peritoneal carcinoma, high grade serous or endometrioïd, with the exception of mucinous, clear cell and carcinosarcoma histologies; performance status less than 2; documented International Federation of Gynecologic Oncology (FIGO 2014, Appendix 1) stage IIIB-IIIC-IV unsuitable for complete primary cytoreductive surgery (confirmed by open laparoscopy or by laparotomy); patient must be judged resectable after 3 courses of Neoadjuvant chemotherapy; adequate bone marrow, liver and renal function to receive chemotherapy and subsequently to undergo surgery: white blood cells (WBC) more than 3x109/L, absolute neutrophil count (ANC) more than 1,5x109/L, platelets (PLT) more than 100x109/L, hemoglobin (Hb) more than 9 g/dL, serum creatinine less than 1.25 x upper normal limit (UNL) or creatinine clearance more than 30 mL/min, serum bilirubin less than 1.25 x UNL, AST(SGOT) and ALT(SGPT) less than 2.5 x UNL; signed informed consent obtained."	Subjects meeting any of the following criteria must not be enrolled in the study: Mucinous, clear cell , carcinosarcoma and low grade serous carcinomahistologies; synchronous or previous other malignancies within 3 years prior to starting study treatment, with the exception of adequately treated non-melanomatous skin cancer or carcinoma in situ (of the cervix or breast or other sites); patients with brain metastases, seizure not controlled with standard medical therapy, or history of cerebrovascular accident (CVA, stroke) or transient ischemic attack (TIA) or subarachnoid hemorrhage within 6 months from the enrollment on this study; any other concurrent medical conditions contraindicating surgery or chemotherapy that could compromise the adherence to the protocol; pregnant or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-57cqdx	Delayed Reconstructioon of Irradiated Breast  with fat grafting	Recruiting	Intervention	2017-10-29	<NULL>	<NULL>	1450	Delayed breast reconstruction with autologous fat grafting and  implant  after mastectomy and radioterapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti -CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti -CAISM	https://ensaiosclinicos.gov.br/rg/RBR-57cqdx	<NULL>	Health woman; age between 21 and 70 year-old; who underwent mastectomy followed by radiotherapy, after at least 6 month of adjuvant treatment conclusion and that wish delayed breast reconstruction; agree breast reconstruction with alloplastic material and autologous tissue; woman in oncological follow-up; agree with all necessary procedures, as well as all outpatient returns and proposed photographies; assign the Consent Form; be free of tumor relapse or any radiological alterations	smoking volunteers; history of alcohol or drug abuse; diagnoses of tumor recurrence or radiological alterations in mammary topography; obesity; loss of segment; cognitive difficulties	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-4z7fhwb	Deliberate practice as a teaching strategy for family members of children with special health needs	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7182	Rapid cycle deliberate practice as a training strategy for family children with special health needs to perform pediatric cardiopulmonary resuscitation: a randomized simulation based study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-16	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4z7fhwb	<NULL>	Family members of children aged one year old to twelve years old classified as children with special health needs according to the children with special health care needs screener instrument; both genders; self-declared as literate and minimum age of 18 years	Family members under eighteen years of age; those who do not have Brazilian Portuguese as their mother tongue; those with a self-declared physical difficulty that prevents them from participating in the training; family members who accompany children with special health needs with tracheostomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-89xvwj	Demographic mapping and characterization of physical therapy care profile offered in neonatal intensive care units in the city of Rio de Janeiro	Data analysis completed	Observational	2016-04-05	<NULL>	<NULL>	787	Characterization of physical therapy profile offered in neonatal intensive care units in Rio de Janeiro City	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-89xvwj	<NULL>	Hospitals offering neonatal intensive care in Rio de Janeiro during the study period.	They were excluded from the study hospitals whose leaders delivered the questionnaires incompletely and hospitals whose ICUs were mixed, that is, also provided assistance to pediatric public.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-10bqkrcw	Dental and periodontal manifestations in individuals with occlusal overload	Not yet recruiting	Observational	2024-03-22	<NULL>	<NULL>	6888	Occlusal pathologies in individuals with occlusal overload	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10bqkrcw	<NULL>	Voluntary individuals; toothed; without specific complaints; of both sexes; aged 18 years or older; to read and agree to the Informed Consent Form	Individuals who do not have a compatible smartphone to respond to the required questionnaires; wearers of full or partial removable dentures in one or both arches; with fixed protocol-type prostheses; in orthodontic treatment or still in upper retainer use; with iodine allergy; with active periodontal disease; using an occlusal splint; using a mouthguard; on continuous Selective Serotonin Reuptake Inhibitor (SSRI) medication; with special needs; pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-3xfbygd	Dental and skeletal comparison of rapid maxillary expansion supported by 2 versus 4 miniscrews during late adolescence	Recruiting	Intervention	2023-10-31	<NULL>	<NULL>	6551	Dentoskeletal comparison of rapid maxillary expansion anchored in 2 versus 4 miniscrews	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-12	Bauru Dental School - University of Sao Paulo	Bauru Dental School - University of Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3xfbygd	<NULL>	The inclusion criteria consist of: (1) patients of both sexes; (2) age between 14 and 18 years, in the final stage of mixed or young permanent dentition; (3) patients with unilateral or bilateral posterior crossbite; (4) patients with maxillary atresia.	The following will be excluded: (1) patients with a history of orthodontic treatment; (2) patients with systemic or neurological conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-3wq9zxw	Dental bleaching in patients with restored non-carious cervical lesions.	Recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8962	Tooth sensitivity and bleaching efficacy in patients with restored non-carious cervical lesions: a non-randomized clinical trial	<NULL>	4, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Tuiuti do Paraná	<NULL>	<NULL>	<NULL>	Age equal to or greater than 18 years; good systemic and oral health; presence of the upper right canine with shade A2 or darker according to the Vita Classical shade guide; absence of restorations, cracks, or structural alterations in the anterior teeth for inclusion in the control group with sound teeth; presence of at least one non carious cervical lesion restored with composite resin in the anterior teeth for inclusion in the experimental group, with the restoration classified as good or excellent according to the World Dental Federation FDI criteria.	Presence of periodontal disease, carious lesions, visible cracks, fractures, previous endodontic treatment, or extensive restorations in the anterior teeth; use of orthodontic appliances or dental prostheses; severe intrinsic discolorations such as tetracycline staining, fluorosis, or grayish tooth discoloration; previous history of dental bleaching; presence of conditions associated with pre-existing sensitivity such as gingival recession, dentin exposure, or parafunctional habits such as bruxism; pregnancy or lactation; smoking habit; regular use of analgesic or anti-inflammatory medications.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-575f79	Dental canal infections and Impact on Quality of Life	Recruitment completed	Observational	2019-06-21	<NULL>	<NULL>	2779	Apical Periodontitis and Impact on Quality of Life	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-03-26	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-575f79	<NULL>	Patients older than 18 years with clinical and radiographic evidence of apical periodontitis (chronic periapical changes) requiring endodontic treatment will be included in the present study sample. Those individuals who have teeth that do not respond to the sensitivity test; have not received previous endodontic treatment and present clinical and radiographic evidence of apical periodontitis will be included.	Pregnant women, teeth with previous endodontic treatment; and number of teeth present of less than 10 will be excluded. Patients who use chronic steroid anti-inflammatory drugs will also be excluded. Patients with severe systemic complications or who use medication that requires medical consultation prior to dental treatment. Patients with communication difficulties noted during the interview. Patients who have teeth with extensive loss of dental structure that require prosthetic rehabilitation for rehabilitation will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-8mb3ws4	Dental care of critical patients and its influence on the modulation of the oral bacterial microbioma	Data analysis completed	Intervention	2022-07-25	<NULL>	<NULL>	5508	Analysis of the salivary microbiome of critically ill patients and its relationship with nutritional status and antibiotic resistance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-07	Universidade do Oeste de Santa Catarina	Hospital Unimed de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-8mb3ws4	<NULL>	patients admitted to the Intensive Care Unit; on mechanical ventilation; older than 18 years	patients who had a current diagnosis and/or salivary gland disorders (Sjogren&apos;s syndrome, salivary gland tumor, parotitis); cancer patients regardless of the stage of the disease, psychiatric patients,; postoperative discharge within the first 24 hours; patients admitted from other institutions already on mechanical ventilation and oral and maxillofacial trauma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-3mxk7tc	Dental implants enhance denture stability in diabetic patients: Practical and random study	Not yet recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8911	Retention of lower complete dentures by dental implants in diabetic patients: A randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	The inclusion criteria for this study will be: Patients with type I or type II diabetes; Patients who are completely edentulous in the lower arch; Patients who do not wear prostheses or who have inadequate complete dentures; Patients that was submitted to tooth extractions at least 12 months prior to the rehabilitation procedure (completely edentulous for at least 1 year); Patients between 40 and 70 years old	Patients with the following characteristics will be excluded from this study: Partial of dentate patients; Smokers who smoke more than 10 cigarettes per day; Users of medications that alter bone metabolism; Pregnant or breastfeeding; 6) patients who do not understand the terms of the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-8t6c99	Dental implants installed and restored provisionally immediately after tooth extraction in the aesthetic region of the smile	Recruiting	Intervention	2018-12-18	<NULL>	<NULL>	2826	Immediate placement and provisionalization of implants in the aesthetic zone	<NULL>	1, n/a, single-blind	1	<NULL>	<NULL>	<NULL>	2018-11-01	Faculdade de Odontologia - UERJ	Faculdade de Odontologia - UVA	https://ensaiosclinicos.gov.br/rg/RBR-8t6c99	80	Indication of treatment with immediate dental implants in the esthetic zone	Patients ASA III or more; Patients with systemic alterations that may interfere with osseointegration; Pregnant patients; breastfeeding patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-4smcqb	Dental sealing of teeth  with resinous materials applied by dentistry students.	Recruitment completed	Intervention	2018-07-26	<NULL>	<NULL>	2348	The success rates of glass ionomer cement and resin-based sealants placed by third-year undergraduate dental students	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4smcqb	<NULL>	Presence of at least one permanently erupted posterior permanent tooth with sealant; minimum age of 12 and maximum of 32 years; do not use orthodontic appliances; not be using medication that could influence the salivary flow; not being pregnant; possibility of attending return visits.	Teeth with restorations and sealants in the same tooth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-4ng46xj	Dental Sensitivity to in-office bleaching after use of a new Ibuprofen Nanogel	Recruiting	Intervention	2024-03-18	<NULL>	<NULL>	6865	Sensitivity to in-office bleaching by application of a new Ibuprofen Nanogel	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4ng46xj	<NULL>	Be between 18 and 50 years old. Good general and oral health. Have at least 6 anterior teeth in the maxilla free of cavities and restorations and with color A2 or darker on the canine according to the VITA color scale classic never bleached before	"Prosthesis users. Orthodontic appliance users. Patients with severe staining caused by tetracycline, fluorosis,
trauma or teeth with pulp necrosis. Pregnant or breastfeeding women. Patients with bruxism, gingival recession, visible dentin exposure and cracks extensive. Patients with previous or current systemic health problems (stomach, heart, kidneys and liver), continuous users of anti-inflammatories and/or analgesics. Allergic to Ibuprofen or other components of the nanogel"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-235jts	Dental sensitivity: prevalence and treatment	Recruiting	Intervention	2019-10-29	<NULL>	<NULL>	3141	Cervical dentin hypersensitivity: prevalence and treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-235jts	<NULL>	Orto1 study: patients older than 18 years; completed corrective orthodontic treatment; permanent dentition erupted prior to orthodontic treatment; agree to participate; good general health. Orto2 study: patients older than 18 years; completed corrective orthodontic treatment; permanent dentition erupted prior to orthodontic treatment; agree to participate; good general health; clinically diagnosed dentin hypersensitivity. Perio1 study: patients older than 18 years; completed non-surgical periodontal treatment; agree to participate; have good general health. Perio2 study: patients older than 18 years; completed non-surgical periodontal treatment; agree to participate; good general health; clinically diagnosed dentin hypersensitivity.	Orto1 study: in orthodontic retreatment; use of anti-inflammatory, analgesic and / or psychiatric medications (chronic or up to 72 hours prior to clinical evaluations); pregnant or lactating women; carious lesions; endodontic treatment; pulp and / or periapical lesion; in treatment for dentin hypersensitivity; who underwent periodontal surgery in the last 3 months; restored in the last 3 months; fixed or removable prosthetic abutments; with prosthetic crowns; extensively restored; restorations covering the cervical region and / or regions that interfere with the assessment of dentin hypersensitivity. Orto2 study: in orthodontic retreatment; use of anti-inflammatory, analgesic and / or psychiatric medications (chronic or up to 72 hours prior to clinical evaluations); pregnant or lactating women; carious lesions; endodontic treatment; pulp and / or periapical lesion; in treatment for dentin hypersensitivity; who underwent periodontal surgery in the last 3 months; restored in the last 3 months; fixed or removable prosthetic abutments; with prosthetic crowns; extensively restored; restorations covering the cervical region and / or regions that interfere with the assessment of dentine hypersensitivity; allergic to the components of the formulations that will be used. Period study1: use of anti-inflammatory, analgesic and / or psychiatric medications (chronic or up to 72 hours before clinical evaluations); pregnant or lactating women; carious lesions; endodontic treatment; pulp and / or periapical lesion; in treatment for dentin hypersensitivity; who underwent periodontal surgery in the last 3 months; restored in the last 3 months; fixed or removable prosthetic abutments; with prosthetic crowns; extensively restored; restorations covering the cervical region and / or regions that interfere with the assessment of dentin hypersensitivity. use of anti-inflammatory, analgesic and / or psychiatric medications (chronic or up to 72 hours prior to clinical evaluations); pregnant or lactating women; carious lesions; endodontic treatment; pulp and / or periapical lesion; in treatment for dentin hypersensitivity; who underwent periodontal surgery in the last 3 months; restored in the last 3 months; fixed or removable prosthetic abutments; with prosthetic crowns; extensively restored; restorations covering the cervical region and / or regions that interfere with the assessment of dentine hypersensitivity; allergic to the components of the formulations that will be used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-23j9msk	Dentin Remineralization using a Composite containing Calcium and Phosphate associated to a mineral precursor	Recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6378	Dentin remineralization using a composite containing calcium orthophosphate particles associated to a mineral precursor in liquid phase (polymer-induced liquid-precursor, PILP): randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-21	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23j9msk	<NULL>	Children aged between six and nine years; both sexes; good general health; presence of at least one active carious lesion on the occlusal surface of the primary molar classified as International Caries Detection and Assessment System (ICDAS) 5 or 6 scores;  final stages of their physiological root resorption with permanent tooth sucessor presenting 2/3 of the formed root	Presence of symptoms of irreversible pulp injury (spontaneous pain or pressure); pulp exposure; fistula; soft tissue edema and abnormal mobility; presence of radiolucent areas in the interradicular/periapical regions; internal and external dentin resorptions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-4pgktym	Dentoskeletal and upper airway changes after micro-implant-assisted palatal expansion (MARPE) in patients in the final stages of suture fusion: a randomized controlled clinical trial	Data analysis completed	Intervention	2020-12-17	<NULL>	<NULL>	4431	"Analysis of the anteroposterior and vertical effects in the final stages of suture fusion
intermaxillary after using the Palatino Rapid Expander assisted by Mini-Implants"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Centro Universitário da Fundação Hermínio Ometto	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4pgktym	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 60 years; presence of maxillary atresia; ossification level of the complete palatal suture.	Syndromic volunteers; history of orthodontic treatment; history of craniofacial bone fractures; diagnoses of bone or metabolic pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:11
RBR-6gpv7vs	Denture adhesives for Removable Partial Dentures wearers	Recruiting	Intervention	2022-10-18	<NULL>	<NULL>	5667	Impact of denture adhesives use on mastication, nutrition, and quality of life of Removable Partial Dentures wearers: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-30	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6gpv7vs	<NULL>	Volunteers with 40 years old or more; completely edentulous in the upper jaw and partially edentulous in the lower jaw (Kennedy class I); having only the canine and incisors teeth (from 33 to 43).	Volunteers who have a previous history of allergy to the components of denture adhesives; parafunctional habits and/or temporomandibular disorders (according to the Diagnostic Criteria of Temporomadibular Disorders); uncontrolled systemic diseases, cognitive disorders; history of neurological diseases; ischemic or hemorrhagic stroke; traumatic brain injury; Parkinson&apos;s or Alzheimer&apos;s patients; salivary flow below 0.6 mL/min; who have previously used denture adhesives in lower removable partial dentures; smokers; alcoholics will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-46ykd6t	Denture liner material with special antifungal medications in the treatment of Oral Candidiasis	Recruiting	Intervention	2024-08-14	<NULL>	<NULL>	7217	Tissue conditioner containing Nystatin Complexed with Beta-Cylodextrin for the treatment of denture stomatitis: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Unisagrado	https://ensaiosclinicos.gov.br/rg/RBR-46ykd6t	<NULL>	Volunteer users of conventional removable upper denture; clinical diagnosis for denture stomatitis in the palatal mucosa supporting the complete denture, both genders, any age, regardless of the condition of the mandibular arch and the use and status of the lower denture.	Volunteers with anemia; immunocompromised; with uncontrolled endocrinopathologies; in a therapeutic regimen with antibiotics, steroids or antifungals in the last three months; under antineoplastic treatment by radio or chemotherapy; users of the same upper complete denture for over 30 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-4vsv5c	Depression Acceptance and Commitment Therapy in the Elderly	Data analysis completed	Intervention	2019-09-17	<NULL>	<NULL>	2954	Cognitive Behavioral Therapy and Geriatric Depression: A Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4vsv5c	<NULL>	60 years or older; reside in the research city; not being in psychotherapy, achieving the expected score on the EDG-15 (instrument for geriatric depression) and the MMSE (cognitive deficits).	Not reside in the research city; being in psychotherapy; present evidence of dementia (MMSE) or absence of depressive symptoms (EDG-15) in the respective instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-23j2m8	Dermatological evaluation of  GINOCONFORT	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3716	Dermatological evaluation of the photoirritating and photosensitizing potential_27567	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2020-08-01	INFAN - Indústria Química e Farmacêutica Nacional	INFAN - Indústria Química e Farmacêutica Nacional	https://ensaiosclinicos.gov.br/rg/RBR-23j2m8	<NULL>	Male and female participants; Age group between 18 and 70 years; Be in agreement not to change your habits of using health products, including hygiene; Skin intact in the test region; Agreement to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for reading the dressings; Understanding, agreement and signing the Informed Consent Form (ICF).	Pregnancy or risk of pregnancy and / or lactation; (when women); Atopic or allergic background to health products; Use of anti-inflammatory drugs 30 days and / or immunosuppressive for up to three months before selection; Diseases that cause suppression of immunity, such as Diabetes, HIV, etc .; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the evaluation; Prediction of intense exposure to sunlight or tanning sessions during the study period; Prediction of sea baths, swimming pool or sauna during the study; Water sports during the study; Dermographism (property that has the skin of certain individuals to swell and redden in the place where it is streaked by something relatively sharp); Use of oral or topical treatment with vitamin A acid and / or its derivatives up to 1 month before the beginning of the study; Aesthetic and / or dermatological treatment on the body within 03 weeks before selection; Vaccination scheduled during the study period or up to 03 weeks before selection; History of sensitization and irritation to a topical product; Active skin pathologies (local and / or disseminated) that may interfere with the results of the study; Use of new drugs and / or health products during the study; Skin reactivity; Previous participation in studies with the same product; Known history or suspected intolerance to any ingredient in the study products (test or comparative products); History of lack of adherence or unwillingness to adhere to the study protocol; Other conditions considered by the researcher to be reasonable for disqualifying participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-3rgpwg	Dermatological Evaluation of HB22	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	5584	Assessment of primary and cumulative irritation potential, sensitization potential of the skin and the potential for phototoxicity and photoallergy of the skin supervised by dermatologist for vaginal moisture restorative product HB22	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-30	INFAN - Indústria Química e Farmacêutica Nacional	INFAN - Indústria Química e Farmacêutica Nacional	https://ensaiosclinicos.gov.br/rg/RBR-3rgpwg	<NULL>	Male and female participants; Age group between 18 and 65 years; Be in agreement not to change your habits of using health products, including hygiene; Skin intact in the test region; Agreement to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for reading the dressings; Understanding, agreement and signing the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy and / or lactation; (when women); Atopic or allergic background to health products; Use of anti-inflammatory drugs 30 days and / or immunosuppressive for up to three months before selection; Diseases that cause suppression of immunity, such as Diabetes, HUman Immunodeficience Vírus, etc; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the evaluation; Prediction of intense exposure to sunlight or tanning sessions during the study period; Prediction of sea baths, swimming pool or sauna during the study; Water sports during the study; Dermographism (property that has the skin of certain individuals to swell and redden in the place where it is streaked by something relatively sharp); Use of oral or topical treatment with vitamin A acid and / or its derivatives up to 1 month before the beginning of the study; Aesthetic and / or dermatological treatment on the body within 03 weeks before selection; Vaccination scheduled during the study period or up to 03 weeks before selection; History of sensitization and irritation to a topical product; Active skin pathologies (local and / or disseminated) that may interfere with the results of the study; Use of new drugs and / or health products during the study; Skin reactivity; Previous participation in studies with the same product; Known history or suspected intolerance to any ingredient in the study products (test or comparative products); History of lack of adherence or unwillingness to adhere to the study protocol; Other conditions considered by the researcher to be reasonable for disqualifying participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-3hnmbdt	Dermatological test on revitalizing lotion and restorative lotion	Not yet recruiting	Intervention	2023-05-02	<NULL>	<NULL>	6045	Assessment of primary and cumulative irritation potential and sensitization potential from the skin supervised by a dermatologist to the investigational products lotion revitalizing and restorative lotion	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-06-15	Kosmoscience Ciência e Tecnologia Cosm Imp Exp Ltda	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-3hnmbdt	<NULL>	Healthy research participant; age range between 18 and 70 years; both sexes; phototype (Fitzpatrick): I to IV; agree to adhere to the requirements of the study in combating the COVID-19 pandemic, through preventive measures: use a mask as recommended by the WHO; use the mask while traveling to the research center and during study procedures; maintain social distancing; frequently wash your hands with soap and/or alcohol gel and attend the research center only at scheduled times to avoid crowds; agreement not to wet the site during the entire test period; understand the test procedures and agree to adhere to the study requirements; absence of inflammatory dermatoses or tattooing at the application site; signature of the Free and Informed Consent Term (TCLE)	Gestation; lactation; participants who have hyperthermia (body temperature greater than or equal to 37.5°C); participants who have been diagnosed with COVID-19 by RT-PCR test or by the presence of IgM antibodies in the serology test, in the last 4 weeks or who are showing the following symptoms: dry or productive cough, sneezing, runny nose, body pain , headache, anosmia (loss of smell), ageusia (loss of taste) and/or any other symptom that may be related to covid-19 at the discretion of the investigator; participant who belongs to the risk group for COVID-19, that is, with chronic cardiovascular, renal and respiratory problems, immunosuppression or other conditions that the doctor judges as belonging to the risk group; participants with heart diseases (for example, but not limited to: atrial fibrillation, obstructive coronary artery disease); participants with kidney and/or neurological diseases; participants with severe or decompensated pulmonary and/or respiratory diseases; use of corticoids, antihistamines and/or anti-inflammatories; presence of localized or generalized dermatological diseases; presence of active inflammatory dermatoses in the test region; frequent exposure to the sun or tanning beds; having participated in an allergenicity study within a period of less than four weeks from the start of the study; research participants with a history of allergy to the material used in the study; history of atopy; history of pathologies aggravated or triggered by ultraviolet radiation; people with immunodeficiencies; prediction of intense sun exposure or tanning session during the study period; plan to take a bath in the sea, pool or sauna during the study; research participants who practice water sports; survey participants with dermographism; use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticoids up to 2 weeks before selection; vitamin A acid treatment and/or its derivatives orally or topically up to 01 month before the beginning of the study; body aesthetic and/or dermatological treatment up to 03 weeks before selection; prediction of vaccination during the study or up to 03 weeks before the study; any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study; history of non-adherence or unwillingness to adhere to the study protocol; professionals directly involved in carrying out this protocol and their families; currently participating in another study; any condition that, in the opinion of the researcher, could compromise the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-59h84g	Description of health-related quality of life and evaluation of the use of Cosmetic Camouflage in patients with Systemic Lupus Erythematosus and skin scars caused by the disease	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1781	Impact of the use of Cosmetic Camouflage on health-related quality of life in patients with Systemic Lupus Erythematosus and cutaneous manifestations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Santa Casa de Misericórdia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-59h84g	<NULL>	Age greater than or equal to eighteen years; signature of the Informed Consent Term (TCLE);presence of scars of cutaneous manifestations of the disease on the face	Moderate to severe disease activity at the time of inclusion or during the study (defined as SLEDAI 2k-Modified&gt; 4, excluding cutaneous manifestations); not understanding the questionnaires; patients who have initiated psychological and / or psychiatric treatment, with or without medication, within four weeks prior to the start of the study and during its execution or who have undergone treatment modification during the study; development of allergic reaction to the cosmetic product used; moderate to severe cutaneous activity assessed by a rheumatologist	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-5pz9pwv	Description of ocular alterations in patientes with Sistemic Lupus Erythematosus	Recruiting	Observational	2022-06-20	<NULL>	<NULL>	5434	Prevalence of ophthalmologic alterations in patients with systemic lupus erythematosus	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-01	Universidade Federal da Bahia	Servicos Medicos de Oftalmologia - SEMOF	https://ensaiosclinicos.gov.br/rg/RBR-5pz9pwv	<NULL>	Patients with SLE will be recruited at the Rheumatology outpatient clinic of HUPES and must meet the inclusion criteria for SLE according to the American College of Rheumatology updated in 2019 (16).  Patients over 18 years of age followed at the Hupes Rheumatology outpatient clinic will be selected	Exclusion criteria will be patients presenting clinical diagnosis of another rheumatologic disease; HIV; HTLV; severe Arterial Hypertention; diabetes mellitus and individuals who have other ophthalmologic pathologies not related to SLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-6wkrrd	Description of the clinical characteristics of patients with inflammatory bowel diseases in public hospitals at northeastern Brazil	Recruiting	Observational	2020-04-29	<NULL>	<NULL>	3791	Characterization of the clinical-epidemiological profile on Inflammatory Bowel Disease in a prospective cohort at referral outpatient clinic unit in some States in the Northeast of Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-19	Instituto Autoimune	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6wkrrd	<NULL>	Individuals diagnosed with Crohn&apos;s disease, ulcerative colitis or colitis undetermined, proven by clinical, radiological, endoscopic and ; or histopathological tests, which maintained regular follow-up at the outpatient inflammatory bowel disease of the Gastroenterology service in the hospitals involved in the project.	Absence of criteria for definitive diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-10shkvkk	Desensitizing agents in the treatment of dentin hypersensitivity	Recruiting	Intervention	2024-04-06	<NULL>	<NULL>	6923	Influence of active and passive application of desensitizing agents in the treatment of dentin hypersensitivity	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Uberlândia	Escola técnica de Saúde - ESTES	https://ensaiosclinicos.gov.br/rg/RBR-10shkvkk	<NULL>	Patients with Dentin Hypersensitivity; individuals interested in Dentin Hypersensitivity treatment; agree to participate and sign the informed consent form (ICF); participants aged between 18 and 60 years; both genders	Presence of caries or unsatisfactory restorations causing dentin sensitivity; patients undergoing orthodontic, periodontal treatment, or dental bleaching process; presence of severe bruxism and loss of vertical dimension; presence of spontaneous tooth pain, indicating pulpitis; maintenance of inadequate oral hygiene; diagnosis of periodontal disease; users of extensive dental prostheses; pregnant or lactating women; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-8hr69v	Desprescribing benzodiazepine protocol.	Recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4205	Effect and feasibility of implementing a desprescribing benzodiazepine protocol.	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal de São João del-Rei	Universidade Federal de São João del-Rei	https://ensaiosclinicos.gov.br/rg/RBR-8hr69v	<NULL>	"First stage: medical professionals, nurses and pharmacists with clinical and/or academic experience in the care of the elderly will be included. For analysis of the understanding of the content of the messages will be included seniors who are 60 years or older, who can read and who do not use benzodizepines;
Second and third stages: Elderly will be included from all units in the urban area of the municipality in chronic use of benzodiazepines for anxiety and insomnia, administered daily for at least three months, which were attended in one of the ESF."	Patients who use benzodiazepines for the treatment of epilepsy, psychiatric illness with a history of psychosis and alcohol and illegal drug addicts will be excluded; patients who are not cognitively competent, according to the mini-mental state examination - MEEM-23.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-2khq5gc	Detailed analysis of the cellular composition of the Cell-Rich Fraction of fat tissue harvested using Traditional or Focused Light Beam-Assisted Suction	Recruiting	Intervention	2025-12-03	<NULL>	<NULL>	8613	Cellular and molecular characterization of the Stromal Vascular Fraction of adipose tissue obtained by Traditional or Laser-assisted liposuction	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-31	Instituto Nacional de Traumatologia e Ortopedia	<NULL>	<NULL>	<NULL>	Adult participants aged between 40 and 75; Both gender; Presenting full range of motion (0 to 120°); Patients with mild to moderate primary osteoarthritis classified by radiographs (anteroposterior projection) using the Kelgren-Lawrence classification less than or equal to III; residents of the city of Rio de Janeiro	Rheumatological disease; systemic inflammatory disease; active neoplasia; heart disease; renal or hepatic failure; grade III obesity (BMI&gt; 40); positive viral diagnosis by serology or antigen (hepatitis B, C and HIV); patients with a history of trauma, infection or previous surgery in the involved joint; patients with alteration in the measurement of the mechanical axis of the lower limbs (varus or valgus greater than 5°; corticosteroid infiltration in the last 6 weeks; patients who used  non-steroidal anti-inflammatory drug (NSAIDs) in the previous two weeks; patients undergoing viscosupplementation in the last year	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-4smr5g	Determinants values of fasting glucose and glycated hemoglobin for the dental complications occurrence in patients with type 2 diabetes mellitus	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	84	Determination of fasting glucose and glycated hemoglobin levels preditives to dental complications occurrence in patients with type 2 diabetes mellitus	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-05-05	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas - Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4smr5g	<NULL>	"Diabetes patients assisted at the Diabetes Clinic of the Division of Endocrinology, Hospital das Clinicas, Faculty of Medicine of Ribeirao Preto / USP (HC-FMRP/USP), and the DAPE Service (Demystifying Dental Care to Patients with Special Needs) School of Dentistry of Ribeirão Preto / USP (FORP-USP)will participate in this study and nondiabetic individuals assisted at the Faculty of Dentistry of Ribeirão Preto - USP (FORP / USP).
 Selected patients will be diagnosed with type 2 diabetes based on the recommendations of the World Health Organization, with progression of the disease at least 5 years, of both sexes, with no predilection for race, over 18 years. Patients must have indication for periodontal dental treatment and/or surgery."	"Type 2 diabetics patients presenting microvascular and macrovascular complications (diabetic retinopathy with vision loss, diabetic neuropathy, diabetic foot + resulting in amputations, coronary heart disease, peripheral arterial disease, cerebrovascular disease, nephropathy developed with the need for dialysis, except for periodontal disease ) patients with systemic or local infectious diseases beyond the mouth, showing malignancy or any other type of disease and drugs that result in immunosuppression, smoking, individuals who have made use of systemic antibiotics in the three months preceding the study.
 Are also excluded patients with diabetes have changes in dosage of medication taken within 3 months prior to dental care.
 The clinical examination will exclude individuals presenting PSR 1 or 2, presenting less than 6 mouth dental elements, individuals with lesions in the oral mucosa, and those who disagree on signing the informed consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-7wfrs6k	Determination of Anatomic Diameters in Different Dental Groups - An &quot;In Vivo&quot; Study	Data analysis completed	Intervention	2022-01-25	<NULL>	<NULL>	5165	Determination of Anatomic Diameters in Different Dental Groups - An &quot;In Vivo&quot; Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-12	Universidade Paranaense	Universidade Paranaense	https://ensaiosclinicos.gov.br/rg/RBR-7wfrs6k	<NULL>	Patients with one or more dental elements indicated for radical endodontic treatment; that have complete root formation	Dental elements with previously performed endodontic treatments; root curvatures; root resorption processes; anatomical complexity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-7rjx3k	Determination of Glycemic Response after Ingestion of Industrialized Enteral Diets Usually Used in Clinical Practice	Recruitment completed	Intervention	2017-12-12	<NULL>	<NULL>	1519	Glycemic Index of Enteral Formulas and Effect on Glycemic Control of Hyperglycemic Patients Hospitalized in Intensive Care Unit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-23	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-7rjx3k	<NULL>	From 18 to 69 years of age; stable body weight; body mass index (BMI) between 18.5 and 24.9 kg / m2; normal glucose tolerance; without diabetes or pre-diabetes; no history of eating disorders; without gastrointestinal disturbances; no medications that affect glucose tolerance; without pregnancy; without breastfeeding; not intolerant or allergic to any of the foods	Volunteers using medications that could interfere with glycemia; which showed instability of body weight; any metabolic disease (diabetes mellitus; hypoglycemia; hypothyroidism)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-6zw2fnb	Determination of glycemic response to the consumption of two specialized formulas for glycemic control	Data analysis completed	Intervention	2022-08-31	<NULL>	<NULL>	5586	Glycemic response of individuals to the consumption of formula for enteral nutrition	<NULL>	1, n/a, single-blind	1	<NULL>	<NULL>	<NULL>	2018-07-16	Prodiet Medical Nutrition	Food Research Center (Fundação de Amparo à Pesquisa do Estado de São Paulo) / Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6zw2fnb	<NULL>	Healthy volunteers; aged between 18 and 49 years; both genders; with good health conditions according to a report of absence of diabetes, renal and gastrointestinal diseases and hyperthyroidism; having a Body Mass Index (BMI) within the normal range of 18.5 to 24.9 kg/m²; with normal glucose tolerance (between 70 and 99 mg/100 mL in the morning, after fasting for 10 hours) and maximum postprandial blood glucose of 140 mg/100 mL and close to fasting after 2 hours	Volunteers using any type of medication that could affect digestion and absorption of food (antibiotics, medications for diarrhea and constipation) during the study period; hormone therapy; presence of pregnancy or breastfeeding; family history of diabetes; significant glycemic variations in the glycemic response test to the reference food	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-2sv9gw	Determination of the best dose for the electrostimulation of the paravertebral muscles in the force in individuals without chronic low back pain	Recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1950	Determination of the dose-response for the stimulation of the multiphids in the core strength in individuals without chronic low back pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-04	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-2sv9gw	<NULL>	University students of both sexes; aged between 18 and 40 years; without musculoskeletal disease or lesion in the spine or lower limbs	Uncontrolled systemic diseases, such as diabetes or hypertension; as well as volunteers who report systematic physical activity at least twice a week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8tygcz7	Determination of the effectiveness of a mouthwash and nasal spray in clinical improvement, decrease in the number of viruses and their prolonged action in patients with Covid-19	Recruiting	Intervention	2020-12-01	<NULL>	<NULL>	4394	Evaluation of the effectiveness of an oral antiseptic and nasal spray in improving the clinical picture, decreasing viral load and its substantivity in patients with Sars-cov-2	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-16	Universidade Estadual de Londrina	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-8tygcz7	<NULL>	volunteers; infected with SARS-CoV-2; both sexes; age between 18 to 70 years; be able to gargle.	more than 7 days after the onset of symptoms; need for mechanical ventilation; intubated patients; admitted to the ICU.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-5fqffpc	Determination of the glycemic index and glycemic load of an ice cream with polydextrose	Other	Intervention	2022-06-30	<NULL>	<NULL>	5457	Determination of the glycemic index and glycemic load of an ice cream rich in polydextrose. A randomized clinical trial	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2021-08-18	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5fqffpc	<NULL>	Volunteers with absence of metabolic disorders, such as diabetes mellitus; absence of cardiovascular, liver or kidney diseases; cancer; thyroid disorders; absence alcoholism; absence of morbid obesity	Children; pregnant women; elderly, individuals with allergies and/or intolerance to any component of the formulations;  who do not provide authorization by signing the Informed Consent Term; who did take medications in the past three months that affect glycemic metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-4fc33kz	Determination of the glycemic response to the consumption of specialized oral nutritional supplement and specialized high-protein enteral formula for glycemic control	Data analysis completed	Intervention	2024-11-28	<NULL>	<NULL>	7544	Glycemic response of individuals to the consumption of enteral nutrition formula	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-06	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fc33kz	<NULL>	Healthy volunteers; aged between 18 and 45 years; both genders; with good health conditions according to a report of absence of diabetes, renal and gastrointestinal diseases and hyperthyroidism; having a Body Mass Index (BMI) within the normal range of 18.5 to 24.9 kg/m²; with normal glucose tolerance (between 70 and 99 mg/100 mL in the morning, after fasting for 10 hours) and maximum postprandial blood glucose of 140 mg/100 mL and close to fasting after 2 hours	Volunteers using any type of medication that could affect digestion and absorption of food (antibiotics, medications for diarrhea and constipation) during the study period; hormone therapy; presence of pregnancy or breastfeeding; family history of diabetes; significant glycemic variations in the glycemic response test to the reference food	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-10rmznpy	Determination of the progression of Erosive Tooth Wear by two Clinical Methods	Not yet recruiting	Observational	2024-03-12	<NULL>	<NULL>	6850	Validation of two methods of Detection and Clinical Measurement of Erosive Tooth Wear: A prospective Cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	https://ensaiosclinicos.gov.br/rg/RBR-10rmznpy	<NULL>	To be at least 18 years old; have good oral health; present at least one of the conditions: with diagnosis of gastroesophageal reflux disease, receiving medical treatment or taking over the counter medication for gastroesophageal reflux disease, having heartburn episodes, sour taste in the mouth at least twice a week; having recurrent vomiting; daily consumption of acidic foods and drinks	Active caries lesions or defective restorations; pregnant or breast feeding; subjects with denture; subjects under orthodontic treatment; being in another research in the same period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-9gm9bz	Determining factors of prognosis and morbidity in Chronic Chagas Heart Disease - phase III	Recruiting	Intervention	2020-06-12	<NULL>	<NULL>	3919	Determining factors of prognosis and morbidity in Chronic Chagas Heart Disease - phase III	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9gm9bz	<NULL>	"Diagnosis of Chagas disease by at least two of the three positive serological tests for Trypanosoma cruzi (indirect immunofluorescence, indirect hemoglutination and ELISA). Present a stable clinical condition, defined as no acute exacerbation of heart disease in the last three months. Presence of cardiac involvement defined, on echocardiogram, by the presence of left ventricular dysfunction (ejection fraction lower 52% for males and 54% for females). Presence of clinical signs and symptoms of heart failure (NYHA II and III). Not being a smoker and denying routine exposure to smoking
Presence of inspiratory muscle weakness defined with maximum inspiratory pressure values lower 70% of predicted. Be aged between 30 and 60 years. Be sedentary according to the International Physical Activity Questionnaire (IPAQ). Not having previous episodes of stroke and not having pulmonary, renal pathologies, musculoskeletal limitations and diabetes mellitus, conditions that alter the ability to perform functional tests."	"Warm-up activities before carrying out stress tests as well as any other contraindications to the maximum and submaximal tests.
Failure to perform the study&apos;s evaluation procedures. Only for the experimental group: do not perform inspiratory muscle training for two days in the same week (at home) or are absent from two supervised sessions during training."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-3w8mnrv	Development and application of a Family-Centered Approach for children with Cerebral Palsy and their families in Brazil	Recruiting	Intervention	2023-07-14	<NULL>	<NULL>	6242	Development and applicability of a Family-Centered Approach of children with Cerebral Palsy in Brazil	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-04	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-3w8mnrv	<NULL>	Children with a previous diagnosis of cerebral palsy or at high risk of delay in neuropsychomotor development identified from screening by the Hammersmith Child Neurological Examination - HINE; age group 0-6 years; both genders; parents&apos; agreement to participate in the research by signing the Free and Informed Consent Form; be undergoing physiotherapeutic treatment previously	Child with a different diagnosis of cerebral palsy; children with difficult-to-control epilepsy; children with other syndromes associated with cerebral palsy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-2vzd48	Development and application of a Phosphorus Counting Table for control of blood level of phosphorus in patients with Bone Disease in hemodialysis	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1794	Characterization and application of a Phosphorus Counting Table for control of hyperphosphatemia in patients with Bone Mineral Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-09	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2vzd48	<NULL>	Patients with chronic kidney disease and disease–mineral and bone disorder in hemodialysis; age range greater than or equal to 18 years; literate or had literate carer; serum phosphorus levels less than or equal to 7,8mg/dL after thirty days of phosphate binder cessation; sign the written informed consent form	Patients in use of anti-inflammatory hormones; patients with neoplasias or active infectious diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-5kj6n2	Development and Application of Educational Multimedia in oral health orientation in patients with use of teeth apparatus	Recruiting	Intervention	2018-08-23	<NULL>	<NULL>	2142	Development and Application of Educational Multimedia in oral health orientation in orthodontic patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade Federal de Sergipe	Atlântico Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-5kj6n2	<NULL>	Patients without orthodontic appliance or fixtures installed; above 18 years; access to a smartphone; without history of orthodontic treatment.	Patients with orthodontic appliance or fixed fittings installed; children under 18 years of age; without access to a smartphone; with a history of orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-2h29zc	Development and evaluation of a cell phone game on healthy eating for adolescents in the city of Diamantina, Minas Gerais	Recruiting	Intervention	2020-10-02	<NULL>	<NULL>	4318	Development and evaluation of the use of a mobile phone / tablet application as a communication strategy of the Food Guide for the Brazilian Population for adolescents in the municipality of Diamantina, Minas Gerais	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-15	Laboratório de biologia do exercício e imunometabolismo	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-2h29zc	<NULL>	Adolescents aged 14 to 16 who have a smartphone that can receive the application.	Adolescents who do not have a smartphone that can receive the application.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-10t3wc7z	Development and evaluation of flexible sensor devices and construction of plasmid positive controls for molecular diagnosis and detection of residual disease in Leukemia	Not yet recruiting	Observational	2023-08-18	<NULL>	<NULL>	6361	Accuracy of a flexible nanodevice based on DNA probes and conductive polymers for ultrasensitive diagnosis of chimeric oncogenes associated with childhood Lymphocytic Leukemia in health units in Brazil and therapeutic decision under the Brazilian Childhood Leukemia Treatment Group (GBTLI) protocol - 2020	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Instituto Aggeu Magalhães - Fiocruz de Pernambuco	Instituto de Medicina Integral Prof. Fernando Figueira - IMIP	https://ensaiosclinicos.gov.br/rg/RBR-10t3wc7z	<NULL>	Patients with a maximum age of 20 years; both genders; attended at reference services for the treatment of leukemia in Brazil with a clinical and cytological diagnosis of leucemia; who express the desire to participate in the project and the legal guardians sign the Free and Informed Consent Form and the children between 8 and 18 years old sign the Free and Informed Assent Term, providing clinical information, and allowing the analysis of samples (bone marrow) in the laboratory reference of the study in Recife	Patients with mature B-cell Leukaemia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-2zkkxr3	Development and evaluation of the effectiveness of cosmetics in conjunction with aesthetic procedures	Recruitment completed	Intervention	2023-10-17	<NULL>	<NULL>	6512	Assessment of the effectiveness of cosmetic formulations, whether or not combined with non-invasive aesthetic procedures, through Image Analysis or Cutaneous Bioengineering	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Faculdade de Ciências Farmacêuticas da Unicamp	Faculdade de Ciências Farmacêuticas da Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-2zkkxr3	<NULL>	Women; aged 30 to 65 years; agree with the study conditions; ability to understand and follow the instructions; agree to avoid sun exposure during the study; do not use other cosmetics in the test region throughout the study; be available to attend laboratory sessions on scheduled days; do not wash the test skin region for at least 2 hours before analysis; not having performed aesthetic procedures for at least 3 months	Lack of cognitive capacity; not understanding the method to be used; be pregnant or breastfeeding; present lesions compatible with active infectious diseases; history of aesthetic plastic surgery in the facial region; history of use of botulinum toxin, fillers or threads; history of recent facial aesthetic treatment, in less than 3 months; have generalized dermatological diseases, such as psoriasis or vitiligo; allergy to any cosmetic product; present systemic diseases with proven effects on the skin; be on continuous treatment with corticosteroids, antihistamines, diuretics, antibiotics, analgesics, anticoagulants, which directly or indirectly affect the skin; carry out immunosuppressive therapy; being treated for endocrine disorders; oophorectomy or hysterectomy; present allergic reactions in the test region during the study; have lesions, wounds, scars, tattoos or piercings in the test region of the skin; presence of metal pins or plates in the craniofacial region; neoplasms, cancer, growing epiphyseal plate and venous thrombosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-7wqksdc	Development and evaluation of the efficacy of a cosmetic emulsion for skin with Dermatoporosis in people with and without Diabetes	Recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7295	Development and evaluation of the clinical efficacy of a topical formulation for skin with Dermatoporosis in healthy and Diabetic patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-30	Faculdade de Ciências Farmacêuticas da Universidade Estadual de Campinas	Kosmoscience Ciência e Tecnologia Cosmética Importação e Exportação Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7wqksdc	<NULL>	First and second stages of the study - 18 to 60 years old; female; phototype I to VI; normal to dry body skin; intact skin in the study area; agree to comply with the procedures and requirements of the study; sign the Free and Informed Consent Form. Third stage of the study - 60 to 90 years old; both genders; phototype I to VI; agree to comply with the procedures and requirements of the study; sign the Informed Consent Form. Fourth stage of the study - 60 to 90 years old; both genders; phototype I to V; 50% of the panel (25 participants with type I or II diabetes mellitus) and 50% of the healthy panel; agree to comply with the procedures and requirements of the study; agree not to undergo dermatological and/or aesthetic body treatments until the end of the study; sign the Free and Informed Consent Form	History of allergic reactions, irritation or intense sensations of discomfort to topical products: cosmetics or medicines. Skin markings in the experimental area that interfere with the assessment of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, large freckles and warts, sunburn). Patients unable to return for a clinical evaluation. Presence of active dermatoses (local or disseminated) that could interfere with the results of the study. Use of non-hormonal anti-inflammatory drugs, corticosteroids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study. Intense sun exposure or tanning sessions up to 15 days before the initial assessment. Aesthetic or dermatological body treatment up to 4 weeks before the study. Hormonal treatments that have not been stable in the last 3 months. People directly involved in carrying out this study and their families. Participating in another study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-3v7cw2r	Development and testing of tools to facilitate oral hygiene for patients with Neuromotor Disability	Recruiting	Intervention	2025-02-25	<NULL>	<NULL>	7793	Creation and evaluation of tools to help with the oral hygiene of patients with neuromotor disability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3v7cw2r	<NULL>	Patients duly registered at the Clinic for Pediatric Patients with Disabilities of the Department of Pediatric Dentistry and Orthodontics of the Faculty of Dentistry - Federal University of Rio de Janeiro - FO/UFRJ; present cognitive deficit; limiting physical motor disability; do not perform their own oral hygiene, depending completely on a third party to perform this function;  have gingivitis and/or visible biofilm on the day of the clinical examination; age from 5 to 40 years; both sexes	Patients whose guardians/caregivers cannot participate in the interviews; in cases where it is completely unfeasible to manipulate this patient; patients with dental calculus that cannot be removed in an outpatient setting	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-6ddhwvw	Development and Validation of a Mobile Application for Monitoring Musculoskeletal Pain and Guiding Core Muscle Training in Military Police	Recruitment completed	Intervention	2024-03-22	<NULL>	<NULL>	6889	Development and validation of a mobile application to monitor Musculoskeletal Pain and guide Core Training in military police officers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-05	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6ddhwvw	<NULL>	Being a volunteer; Being an active military police officer; Not taking medication that affects pain levels; Having mild to moderate lower back pain;  Not having any injury or condition that prevents the performance of the proposed exercises in this document.	Not completing the nine weeks of the study;  Failing to respond to sociodemographic and musculoskeletal pain/discomfort questions; Sustaining any type of injury or experiencing pain that prevents participation in the study; Initiating medication treatment for pain mitigation;  Increasing the intensity of pain to a very strong level.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-8dgwp2n	Development and validation of the epidemiological diagnostic instrument for Temporomandibular Dysfunctions	Recruiting	Observational	2022-03-07	<NULL>	<NULL>	5261	Development and validation of a instrument to evaluate Temporomandibular Dysfunctions for use in epidemiological surveys	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-10-01	Departamento de Odontologia, Universidade Federal do Rio Grande do Norte	CAPES-Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8dgwp2n	<NULL>	Individuals of both sexes, aged over 18 years, with sufficient capacity to respond to the IDE/DTM and DC/TMD instruments, accept to participate after being informed about the purposes of the research and have Brazilian nationality.	Patients with a history of psychiatric illness, or those with clinical symptoms of TMD that make it impossible for dental examination or pain, as well as those who refuse to participate in the research at any of the foreseen stages will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-4w7hzrc	Development in early childhood after the Covid-19 pandemic: a follow-up study	Recruitment completed	Observational	2026-02-11	<NULL>	<NULL>	8860	Assessment of early childhood development after the Covid-19 pandemic: a cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP - Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Live-born infants and their respective mothers, who were recruited during pregnancy; both sexes; births occurring in partner maternity hospitals	Hospitalization for abortion after fetal death or sexual violence; delivery in another hospital; private insurance births in partner hospitals; obstetric/neonatal emergencies preventing approach; aggressive behavior impairing consent; and women under the prison system	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-2pb8gq	Development of a Brain-controlled Gait Apparatus to restore the walking of people with Spinal Cord Injury	Data analysis completed	Observational	2019-09-18	<NULL>	<NULL>	2968	Walk Again Project: development of a Robotic Orthosis Controlled by Biological Signals to restore the ambulation in patients with Spinal Cord Injury	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-11-04	Associação Alberto Santos Dumont para Apoio à Pesquisa	Associação Alberto Santos Dumont para Apoio à Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-2pb8gq	<NULL>	18 years old or over; Lesion T4 to L2; SCI AIS A, B, C or D; Presence of chronic, traumatic, six months to 3 years of SCI.	"Has seizures; Has contractures in the legs (shortening of a muscle or tendon); Do not have time for project activities; Participates in other research; Cardiopulmonary instability; Abuse of alcohol or drugs, psychiatric illness, or history of head trauma with loss of consciousness within 3 months of recruitment; Use of drugs known to exert negative effects on motor recovery; Cognitive deficit; Pregnancy or of childbearing potential and not using adequate contraception; Presence of ferromagnetic material in the skull, except in the mouth; 
Presence of cardiac and/or neural pacemakers;
Untreated depression; Spasticity at the lower end of a MAS score equal or higher than 2; Uncontrolled diabetes; Severe osteoporosis; Decubitus ulcer that may interfere with the belt placement or any other necessary feature of the LT BWST-assisted robot and the exoskeleton."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-3cpthr	Development of a Brazilian Perinatal Bereavement Guideline	Not yet recruiting	Observational	2020-10-15	<NULL>	<NULL>	4340	The Brazilian Perinatal Bereavement Project. Development and evaluation of Supportive Guidelines for families experiencing stillbirth and neonatal death in public maternities wards in Ribeirão Preto: a quasi-experimental study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3cpthr	<NULL>	To live in one of the municipalities of the Ribeirão Preto region (XIII Regional Health Department, São Paulo State). Have experienced a stillbirth or a perinatal death during the estimated period. Have faced the death of her baby in the following circumstances: pregnancy that lasted more than 20 complete weeks; had a baby weighing at least 500g (stillbirth); had a baby that died no later than twenty-eight days after the birth (neonatal death).	Do not understand Portuguese and have severe mental health impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-7n6n5sd	Development of a diagnostic kit for simultaneous and low-cost detection of viral and bacterial agents associated with Acute Respiratory Infections	Recruitment completed	Observational	2023-11-29	<NULL>	<NULL>	6621	Development of RT-qPCR-HRM for simultaneous detection and low cost of viral and bacterial agents associated to Acute Respiratory Infections	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-09-01	Instituto Nacional de Controle de Qualidade em Saúde	Instituto Nacional de Controle de Qualidade em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7n6n5sd	<NULL>	Clinical samples from participants aged 18 years or over; of both genders; samples with complete information and registered in the Sistema de Ambiente laboratorial (GAL), containing clinical data of patients who were suspected of having COVID-19; samples considered positive for SARS-CoV-2 whose ct (cyclethreshold) is ≤40; samples negative for SARS-CoV-2, with ct (cyclethreshold) &gt;40; acute samples less than 10 days after the onset of respiratory symptoms; samples properly stored at -80ºC; clinical samples from participants with confirmed clinical signs of infections	Participants whose clinical sample does not have sufficient volume to perform the investigational test (volume less than 100 µL); samples registered in the Laboratory Environment System (GAL) with incomplete information; samples stored in conditions unsuitable for the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-5rd2hx	Development of a diaphragm footbed for the treatment of wounds on diabetic feet based on a membrane with natural medicine	Data analysis completed	Intervention	2018-12-17	<NULL>	<NULL>	2390	Development of a Diabetic Foot Insole Derived from Natural Latex with Tissue Neoform Induction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-5rd2hx	<NULL>	Subject of the Regional Hospital of Taguatinga; of both sexes; age from 18 to 75 years; presenting diabetic foot ulcer of neuropathic and / or vascular origin with or without clinical signs of infection; who agree to participate and sign the TCLE (Informed Consent Form); with capacity to provide information about the tests and to collaborate with the project.	Pregnant; patient who drinks alcohol and / or drugs; evidence of osteomyelitis or gangrene somewhere on the affected extremity; topical application at the wound site after the start of the study that were not adopted in this protocol; present discomfort during the treatment application; patients who miss three consecutive times.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-3rh759	Development of a Health Promotion Program for patients with Fibromyalgia	Not yet recruiting	Intervention	2020-02-07	<NULL>	<NULL>	3461	Development of an Interdisciplinary Health Promotion Program for People with Fibromyalgia - Fribro&apos;s Friends	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3rh759	<NULL>	Individuals of both sexes; age equal to or over 18 years; with medical diagnosis of fibromyalgia confirmed by an evaluator according to the Classification Criteria of the American College of Rheumatology revised version of 2016; individuals with preserved speech and hearing ability.	Medical diagnosis of myofascial pain syndrome; extra-articular rheumatism affecting several areas; polymyalgia rheumatica and giant cell arthritis; polymyositis and dermatopolymyitis; tendinopathies; neuropathies; endocrine myopathies; hypothyroidism; hyperthyroidism; hyperparathyroidism; adrenal insufficiency; metabolic myopathy due to alcohol; neoplasms; spinal diseases; Parkinson&apos;s disease; pregnant and lactating women; individuals who have not taken medication for more than three months or with stable pharmacological treatment (more than 3 months); individuals who are absent more than twice in a row in the intervention group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-4c47pt	Development of a liver&apos;s drug at Hospital das Clínicas	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2695	Development of ursodeoxycholic acid 300 mg at Hospital das Clinicas of FMUSP	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-19	Hospital das Clínicas	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4c47pt	<NULL>	Diagnosis of Primary Biliary Cholangitis; Male or female; 18 years old; and atients on regular treatment for at least 6 months with commercial drug (Ursacol)	"Any other co-existing liver diseases; pregnancy; 
-withdrawal of consent; patients not adherent to treatment with reference drug and known intolerance to the study drugs"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-34m423b	Development of a Mathematical Model to calculate the risk of delirium after Oncological Surgeries	Recruiting	Observational	2023-08-04	<NULL>	<NULL>	6308	Development of a Nomogram to predict the likelihood of postoperative delirium in patients undergoing Oncological Surgery	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Fundação Antônio prudente- Hospital A.C.Camargo cancer Center	Fundação Antônio prudente- Hospital A.C.Camargo cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-34m423b	<NULL>	patients over 18 years old;  scheduled to undergo oncology surgeries.	refusal to participate in the study; patients who have undergone another surgical-anesthetic procedure in the last seven days; patients who need another surgical-anesthetic procedure in the first seven postoperative days; patients with confirmed delirium in the preoperative period; patients with a confirmed diagnosis of dementia; patients undergoing OTI/VM (OroTracheal Intubation / Mechanical Ventilation) in the preoperative period; patients remaining under OTI / VM in the POI (immediate postoperative period) for more than 12 hours; neurological surgeries; emergency surgeries .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-3ydggrz	Development of a measure to help predict intubation difficulty Distance from skin to epiglottis	Data analysis completed	Observational	2022-06-08	<NULL>	<NULL>	5418	Development of a new measure to predict difficult airway obtained by ultrasound: cutaneous-epiglottic distance. observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-02	Universidade Estadual Paulista - UNESP	Fundação Centro Médico de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3ydggrz	<NULL>	Adult patients of both sexes who will undergo general anesthesia under tracheal intubation	Obese patients with a BMI greater than 35kg/m2, with obstructive sleep apnea, with a previous history of difficult tracheal intubation or who have any predictive sign of difficult intubation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-2fs9kms	Development of a mobile application and the effectiveness of a brief asynchronous mindfulness and self-compassion intervention for cases of Anxiety, Stress and Depression	Not yet recruiting	Intervention	2023-09-18	<NULL>	<NULL>	6447	Development of a mobile application and the effectiveness of a brief asynchronous mindfulness and self-compassion intervention for cases of Anxiety, Stress and Depression in university students and teachers of basic education: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Centro de Ciências Humanas, Letras e Artes - Universidade Federal da Paraíba	Centro de Ciências Humanas, Letras e Artes - Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2fs9kms	<NULL>	Study 1: be between the ages of 18 and 65; both genders; be Brazilian; being a basic education teacher; have internet access and a cell phone with Android system; be willing to download and use the application; achieving a score greater than 0 on symptoms of depression, anxiety, and stress measured by subscales of the Depression, Anxiety, and Stress Scale (DASS-21) (Vignola &amp; Tucci, 2014). Study 2: be between the ages of 18 and 35; both genders; be Brazilian; be a university student (undergraduate or graduate); have internet access and a cell phone with Android system; be willing to download and use the application; achieving a score greater than 0 on symptoms of depression, anxiety, and stress measured by subscales of the Depression, Anxiety, and Stress Scale (DASS-21) (Vignola &amp; Tucci, 2014)	Studies 1 and 2: already adopting a frequent mindfulness practice in the last 6 months; be using some type of psychotropic medication; being under psychological treatment; have a diagnosis of psychiatric or neurological illness (eg, schizophrenia, borderline personality disorder); not have or be willing to create a Gmail account	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-4q882tg	Development of a mobile application on dental prenatal care and early childhood oral health: using technology as an educational tool to combat misinformation	Recruiting	Intervention	2025-10-14	<NULL>	<NULL>	8407	Development and validation of the effectiveness of a mobile application on dental prenatal care and early childhood oral health: using technology as an educational tool to combat misinformation	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2025-07-28	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo (FORP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-4q882tg	<NULL>	Pregnant women at any gestational age; mothers aged 18 years or older; children up to 6 years of age of both sexes; good general health; smartphone with internet access	Mothers without a smartphone with internet access; mothers under 18 years of age; children older than 6 years; mothers with complete upper and lower dentures; mothers with fixed orthodontic appliances; mothers with learning difficulties	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-7dmd7k	Development of a mobile application to apply questionnaires on diseases in the knees	Not yet recruiting	Intervention	2019-04-03	<NULL>	<NULL>	2583	Development and validation of knee questionnaires: an application for the evaluation of knee injuries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-18	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	https://ensaiosclinicos.gov.br/rg/RBR-7dmd7k	<NULL>	"Age over 65 years;
diagnosis of osteoarthritis of the knee using the criteria for osteoarthritis of the knee of the American College of Rheumatology (ACR, 1986) or to have grade II or III knee osteoarthritis of the Kelgren and Lawrence (KL) scale;
walking independently, without support device;
being for at least six months without practicing resisted physical exercise;
and do not present as follows:
any congenital, traumatic, infectious or deformity abnormality following injury to the knee joint that may have contributed to the development of secondary OA;
inflammatory arthritis (e.g., Rheumatoid Arthritis);
grade IV knee osteoarthritis on the KL scale;
knee flexion deformity greater than 15 degrees;
inability to walk or walk with the aid of devices;
neurological problems;
neuromuscular disease or injury;
surgery on the knee (s) in the last year;
corticosteroid injection in the last three months;
uncontrolled hypertension (&gt; 150/90 mmHg);
myocardial infarction in the last six months;
unstable cardiovascular disease;
conditions that may be exacerbated by the protocol (e.g., unstable angina);
fractures within the six-month period; present painful changes in the hips and / or ankles and / or pain in the lower back; or severe comorbidity that limits participation in the study.
Clinical guidelines established by the ACR include having knee pain on most days of the month and at least 3 of the following 6 criteria: age 50 and older, joint stiffness lasting 30 minutes, crepitation, bone sensitivity, bone augmentation, and heat palpable."	"Not participating in one of the sessions;
Any limitation that impedes the continuity of the participant in the study;
Participants with BMI&gt; 30 kg / m2 (minimize artifact at EMG)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-5hq9y3k	Development of a nurses&apos; training to improve the perception over patients becoming severely ill	Not yet recruiting	Intervention	2022-07-20	<NULL>	<NULL>	5499	Nurses&apos; training for early clinical deterioration assessment and management	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Estadual de Campinas (Unicamp)	University of Rhode Island	https://ensaiosclinicos.gov.br/rg/RBR-5hq9y3k	<NULL>	All the floor nurses, both genders, allocated to an adult inpatient unit at a University Hospital in the state of São Paulo will be considered eligible	All nurses who are inactive, on leave, and on vacation during the data collection period will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-8jd639	Development of a prospective data registry system for urinary incontinence patients	Recruiting	Observational	2020-05-20	<NULL>	<NULL>	3851	Epidemiological and demographic data collect from women Urinary Incontinence	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-12-12	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8jd639	<NULL>	Women with urinary incontinence; referred to the voiding dysfunction sector of the Urology discipline	children; pregnant; women with severe cognitive impairment; patients with severe psychiatric conditions; vesicovaginal fistula; bladder stones; urethral cysts, bladder cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-2frpntv	Development of a Protocol for using Steroids after Cataract Surgery	Not yet recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5727	Development of a Cost-effective Corticosteroids Protocol in the postoperative Cataract Surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto para o Desenvolvimento da Educação Ltda-IPADE/Faculdade	Universitary Center Christus (Centro Universitário Christus - Unichristus)	https://ensaiosclinicos.gov.br/rg/RBR-2frpntv	<NULL>	Patients with cataracts; Over 18 years old; Patients from Instituto Cearense de Oftalmologia cataracts department; Patients who do not have other eye conditions that cause eye inflammation, increased intraocular pressure, decreased visual acuity and macular edema, including diabetic retinopathy; Patients who accepted to participate the study signed the informed consent form.	"Ocular affections which cause inflammation, elevated intraocular pressure, reduced vision acuity and macular edema; Allergy to corticosteroids; Any condition that could interfere to the correct use of the eye drops, including patient&apos;s social and/or economic situation; Use of any eye drops, except lubricants
Ocular or systemic use of Non-steroidal anti-inflammatory drugs, corticosteroids, immunosuppressives or anti-histaminics 2 days before to 21 days after the surgery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-39wj7gh	Development of a questionnaire to identify young people in Brazil at higher risk of dental erosion	Recruitment completed	Observational	2025-04-08	<NULL>	<NULL>	7904	Development and validation of a questionnaire to assess susceptibility to Dental Wear by Erosion in young people in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-22	Faculdade de Ciências da Saúde da Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-39wj7gh	<NULL>	Be within the target audience between the ages of eighteen and twenty-nine; be male or female; sign the informed consent form	Individuals outside the established age range; those who refuse to sign the informed consent form; those who have previously participated to avoid repetition bias;  those without access to devices for remote participation will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-96wctgg	Development of a standardized protocol of neurological manifestations in patients with SARS-CoV-2	Recruiting	Intervention	2022-01-31	<NULL>	<NULL>	5191	Development of a standardized protocol of neurological manifestations in patients with SARS-CoV-2	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-05	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-96wctgg	<NULL>	Individuals over 18 years of age in the acute and subacute phase of COVID-19; functional status between 0 to 2; schooling over 9 years (complete high school); who can independently respond to the test	Individuals who do not adhere to the intervention protocol with one or more absences; who have some type of motor or cognitive impairment during the study period; who present clinical instability during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-10hvfd58	Development of a Treatment Program for people with Binge eating and overweight or Obesity	Recruitment completed	Intervention	2023-04-26	<NULL>	<NULL>	6036	Development of an improved and accessible Treatment Program for people with Binge eating disorder and co-morbid overweight or Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10hvfd58	<NULL>	Age greater than or equal to 18 years; binge eating disorder according to DSM-5 criteria; body mass index between 27 and 45 kgm2; able to read and write; access to a computer with internet; access to a private room to participate in the online therapy sessions; and access to a scale and stadiometer to measure body weight and height	Bariatric surgery in the previous 24 months; currently receiving any other treatment for weight loss/binge eating; clinical conditions that interfere with weight control e.g., Prader-Willi Syndrome, Cushing Syndrome; being pregnant; and severe psychiatric disorder i.e., schizophrenia, bipolar disorder or a high suicide risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-2rdwd3y	Development of advanced automatic systems and treatment protocols for hand rehabilitation	Recruiting	Intervention	2024-12-13	<NULL>	<NULL>	7589	Development of methods and intelligent systems for upper limb rehabilitation	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2024-08-05	Instituto de Ensino e Pesquisa Alberto Santos Dumont	Universidade Federal do Espirito Santo (UFES)	https://ensaiosclinicos.gov.br/rg/RBR-2rdwd3y	<NULL>	Individuals diagnosed with traumatic spinal cord; injury classified as having complete or incomplete tetraplegia (ASIA); with neurologic levels C4–C7; aged between 18 and 60 years; of both sexes; who exhibit some level of motor deficit in the upper limbs and possess adequate cervical control to support the use of virtual reality devices; individuals who are able to attend the intervention site	Participants presenting symptoms of dysautonomia and postural hypotension; presence of skin lesions; uncontrolled pain in the upper limbs; inadequate cervical control for supporting virtual reality devices for an appropriate duration; contractures and/or spasticity(classified by the modified Ashworth scale as grade 2 or higher); surgical procedures (e.g., tendon transfers) or orthopedic trauma (e.g., fracture) within the past 3 months; mechanical ventilation and participants unable to comprehend the information provided in the informed consent or unable to provide valid consent will be excluded; individuals who experience significant discomfort during the proposed activities; those who miss two consecutive sessions; or three alternating sessions during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-6wgkzs8	Development of an Application to improve health in the elderly	Recruiting	Intervention	2023-03-08	<NULL>	<NULL>	5943	Development and Validation of a Multidisciplinary Mobile Application to promote health habits in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-20	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6wgkzs8	<NULL>	People with an age equal to or greater than 60 years who have a cellular device that can support the use of the application and its resources	Having limitations to carry out the assessments included in the project, such as visual and auditory limitations and severe cognitive impairments; The Mini Mental State Examination (MMSE) instrument, developed by Folstein et al (1975), will be used, which allows the assessment of cognitive function and the tracking of dementia conditions. cognitive performance or application design	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-8ymy2sw	Development of an Artificial Intelligence solution for remote movement correction for Physical Rehabilitation	Recruiting	Intervention	2022-08-24	<NULL>	<NULL>	5576	Development and validation of an Artificial Intelligence-based solution for remote motion detection and correction of exercises for Motor Rehabilitation	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Hospital Israelita Albert Einstein	LinkFit	https://ensaiosclinicos.gov.br/rg/RBR-8ymy2sw	<NULL>	Healthy volunteers; over the age of 18; of both sexes; high school education or higher; time of injury and pain greater than six months; and who have been elected for conservative treatment	Volunteers with sensory motor; cognitive; visual and or auditory deficits; presence of neurological and or psychiatric comorbidities; previous or recent surgeries in the segments mentioned above for study; other pain syndromes; discharge after conventional physical rehabilitation program in a period less than two months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-2shm9jp	Development of an instrument to define the risk of respiratory complications in children undergoing non-cardiac surgery	Recruiting	Observational	2022-03-20	<NULL>	<NULL>	5289	Development of a risk model for perioperative respiratory complications in children undergoing to non-cardiac surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-10-01	Hospital de Clínicas de Porto Alegre	Grupo Hospitalar Conceição	https://ensaiosclinicos.gov.br/rg/RBR-2shm9jp	<NULL>	Children under 16 years old, undergoing non-cardiac surgeries	Over 16 years old, undergoing obstetric procedures, transplants or procedures under local anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-249zxxh	Development of an ointment for the treatment of cutaneous Leishmaniasis	Not yet recruiting	Intervention	2022-09-19	<NULL>	<NULL>	5616	"Development and evaluation of a topical formulation containing jucá product
(Libidibia ferrea) for the treatment of cutaneous Leishmaniasis"	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Amazonas - UFAM	INPA - Instituto Nacional de Pesquisas da Amazônia	https://ensaiosclinicos.gov.br/rg/RBR-249zxxh	<NULL>	Age between 18 and 70 years; both genders; Individuals considered healthy after initial clinical and laboratory evaluation; Agreement and voluntary signature of the free and informed consent form	Individuals who present alterations in the pre-treatment clinical and/or laboratory assessment; History of visceral leishmaniasis or American cutaneous leishmaniasis; Liver or kidney dysfunction, diabetes or heart disease; Allergy to the experimental treatment; Pregnant and lactating women; Alcoholics, smokers or those using medication; Patients with chronic diseases and/or infectious diseases such as tuberculosis, leprosy, human immunodeficiency virus, visceral leishmaniasis or American cutaneous leishmaniasis, among others; Patients with a medical history of visceral leishmaniasis or American cutaneous leishmaniasis; Inability or refusal to sign the informed consent form or inability to comply with the experimental protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-2jrv4ff	Development of Artificial Intelligence Models for predicting the evolution of Aging Patterns using Digital Biomarkers	Not yet recruiting	Intervention	2025-12-10	<NULL>	<NULL>	8641	Development of Artificial Intelligence Models for predicting the evolution of Aging Patterns using Digital Biomarkers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	<NULL>	<NULL>	<NULL>	Participants must be 60 years of age or older, of either sex; have agreed to participate by signing the Informed Consent Form ICF or the Informed Assent Form IAF for individuals with greater difficulty understanding or associated cognitive impairment; and possess cognitive capacity that allows them to perform the tasks	Participants unable to understand and execute the specific instructions and commands of the intervention, including those with cognitive or behavioral deficits that prevent effective interaction with the games and tasks; individuals with severe visual or auditory impairments that prevent interaction with the extended reality interface, or unstable medical conditions that may compromise their safe participation; withdrawal from the study; failure to adapt to the proposed intervention protocol; use of medications or substances that significantly interfere with motor control; consecutive absences or absence from scheduled sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-7cr9yvf	Development of CAR-T cells to treat malignant B neoplasms	Not yet recruiting	Intervention	2022-07-30	<NULL>	<NULL>	5519	Development of car-t cell for B malignacies treatment - Phase I clinical trial with autologous T cell genetically modified to express chimeric antigen receptor (car) to treat refractory or relapsed patients with B neoplasm CD19+	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2022-09-01	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-7cr9yvf	<NULL>	Provision of the dated and signed free and informed consent form (IC); express willingness to comply with all study procedures and availability during the study; men or women; age 02 and 70 years; Good general health, proven by medical history; diagnosis of refractory or recurrent ALL or LLC and non-Hodgkin lymphoma; Ability to administer oral medications; for women with reproductive potential: use of highly effective contraceptive for at least 1 month before screening and agree to use a contraceptive method during participation in the study and for an additional 4 months after the completion of the administration of CAR T cells; for men with reproductive potential: use of condoms or other methods to ensure effective contraception with the partner; Agreement to adhere to Lifestyle Recommendations: Women of childbearing potential, defined as all women physiologically capable of becoming pregnant, must use highly effective contraceptive methods at least 4 months after the infusion of CAR-T; Sexually active men must use a condom during sexual intercourse from the moment the project is signed for at least 4 months after the infusion of CAR-T. A condom is required for all sexually active male participants to prevent them from having a child and to prevent delivery of the study treatment via the seminal fluid to their partner. In addition, participants must not donate sperm. The subjects should attend the consultations, do the tests according to the protocol, use antibiotics and other medications as indicated. Individuals must have ALL, LLC or relapsed or refractory lymphoma treated with at least two lines of treatment. The disease must have progressed or show partial remission or the complete response must not have been achieved with the last regimen; individuals with Philadelphia Chromosome positive acute lymphoblastic leukemia (ALL + Ph) are eligible if they have progressed, have a stable or recurrent disease after two lines of treatment, including tyrosine kinase inhibitors (TKIs); Individuals with LNHDGCB (large B-cell non-Hodgkin&apos;s lymphoma) must have progressed, presented with stable disease or recurrence after initial treatment regimens that include an anthracycline and an anti-CD20 monoclonal antibody; Individuals with transformed LF (follicular lymphoma), LZM (mantle zone lymphoma) or LLC / ALL must have progressed, presented with stable disease or recurrence with transformed disease after initial treatment for LNHDCGB; Individuals who had a recurrence ≥12 months after treatment must have progressed after autologous transplantation or be ineligible for autologous transplantation; The patient&apos;s disease must be positive for CD19 by immunohistochemistry or flow cytometry analysis in the last available analysis; 2 to 70 years of age; General status: Adult individuals: ECOG less than or equal 2 for individuals over 16 years old; Lansky greater than or equal to 50% for individuals under 16 years old; Normal Functioning of Organs and Marrow (supportive treatment is allowed according to institutional rules, that is, filgrastim, transfusion): Total bilirubin ≤ 2; AST (TGO) ≤ 5 times the normal limit; ALT (TGP) ≤ 5 times the normal limit; Serum Creatinine ≤ 1.5; Pulse oximetry&gt; 91% in room air; Absence of dyspnea or mild dyspnoea (≤ Grade 1); Forced expiratory volume in 1 s (FEV1) ≥50% or carbon monoxide diffusion test (DLCO) ≥50% of the predicted level; Left ventricular ejection fraction ≥45% confirmed by echocardiogram; individuals must have the following parameters of hematological function: Neutrophil&gt; 1000 / ul; Absolute Lymphocyte Count&gt; 100 / ul; Platelets&gt; 50,000 / ul; Patient should not be excluded if the above parameters are changed due to infiltration of spinal disease; Elimination of prior treatment: At least 2 weeks or 5 half-lives, whichever is longer, must have elapsed since any previous systemic therapy at the time that leukapheresis is planned for the individual, except systemic inhibitory checkpoint therapy / immunostimulant, which requires 5 half-lives. Patient with previous treatment with blinatumumab, at least 4 months after the last application; Individuals must be able to understand in order to be willing to sign an informed consent form.	Autologous transplantation within 6 weeks of the planned infusion of CAR T cells; history of allogeneic stem cell transplantation of hematopoietic stem cells (HSCT) 4 months before the infusion; receiving treatment with CAR T cells outside this protocol; compromise of the active central or meningeal system by tumor. Individuals with untreated brain metastases / CNS disease will be excluded from this clinical study because of their unfavorable prognosis and because they often develop progressive neurological dysfunction that would confuse the assessment of neurological and other adverse events. Patients with a history of CNS or meningeal involvement should be in documented remission by assessing cerebrospinal fluid and contrast-enhanced MRI for at least 90 days before registration; history of active malignancy, other than non-melanoma skin cancer, carcinoma in situ (eg, cervical, bladder, breast); HIV infection; HTLV; individuals with uncontrolled intercurrent disease, among others, existing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, lung abnormalities or psychiatric diseases / social situations that would limit compliance with the requirements of the study; pregnant or lactating women are excluded from this study, as treatment with CAR T cells may be associated with the potential for teratogenic or abortion effects. Fertile women must have a negative serum pregnancy test result. As there is an unknown but possible risk of adverse events in infants secondary to the mother&apos;s treatment with CAR T cells, breastfeeding should be discontinued. These possible risks can also be applied to other agents used in this study. Fertile individuals must be willing to use contraceptives from admission to this study and for 4 (four) months after receiving the preparatory regime; evidence of myelodysplasia or cytogenetic abnormality indicative of myelodysplasia in any bone marrow biopsy before the start of treatment; serological status reflecting active hepatitis B or C infection. Patients who test positive for hepatitis B core antibody, hepatitis B surface antigen (HBsAg), or hepatitis C antibody must have a negative polymerase chain reaction (PCR) result prior to admission. (patients with a positive PCR result will be excluded); serious and / or potentially fatal medical conditions; patients with a clinical history of pathology in the relevant central nervous system such as epilepsy, convulsive diseases, paresis, aphasia, severe brain injury, dementia and Parkinson&apos;s disease; history of autoimmune disease (such as rheumatoid arthritis, systemic lupus erythematosus) in need of immunosuppressive medication in the last 12 months; history of severe hypersensitivity to one of the agents used in the study; creatinine level below 30 ml / min	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-10h3q6sx	Development of new rehabilitation methods to recovery post-stroke patients	Recruiting	Intervention	2024-07-06	<NULL>	<NULL>	7122	Development of new rehabilitation methods for post-stroke patients using brain-computer interface based on motor imagery, virtual reality and robotic devices	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal do Espirito Santo (UFES)	Centro de Reabilitação Física do Estado do Espírito Santo (CREFES)	https://ensaiosclinicos.gov.br/rg/RBR-10h3q6sx	<NULL>	Both genders. Age: over 18 years. Post Stroke: 3 months to 1 year. With residual weakness of affected lower limb. Preserved cognition: MoCA (Montreal Cognitive Assessment ) ≥ 26.  Independence in walking: ability to walk 10 m unaided, speed&gt; 0.4 m/s, with or without assistive device. Spasticity: MAS (Modified Ashworth Scale) ≤ 2	History of more than 1 stroke. Bilateral affection. Vestibular disorders / dizziness. Skin lesions at the electrode site. Osteoporosis. Comorbidities: contractures, severe knee osteoarthritis. Residual flaccidity in lower limbs. Taking anticonvulsant or neuroleptic medicines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-6gfsbv	Development of quercetin-based food	Recruitment completed	Intervention	2020-08-06	<NULL>	<NULL>	4090	Quercetin project: formulation development of quercetin-based nutritional supplement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-10	Laboratório Farmacêutico da Marinha	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6gfsbv	<NULL>	The research subjects will be approximately 50 volunteers, all male. They will be preferentially recruited among the soldiers of the Marine Corps, as they are submitted to the practice of high intensity physical activity and to situations of physical and psychological stress. They must not be carriers of chronic diseases, they must be free from inflammatory and / or infectious diseases and they cannot regularly use anabolic drugs and steroids.	People with inflammatory and / or infectious diseases and regularly using medications and anabolic steroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-3t5ts4	Development of Retinoic Acid Formulation for Acne	Recruitment completed	Intervention	2020-09-16	<NULL>	<NULL>	4248	Development of Retinoic Acid Formulation for Acne	<NULL>	1, n/a, single-blind	1	<NULL>	<NULL>	<NULL>	2018-09-03	Faculdade de Farmácia da Universidade Federal de Minas Gerais	Faculdade de Farmácia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3t5ts4	<NULL>	Healthy volunteers; both genders; age between 18 and 35 years	Present hypersensitivity to any of the components of the formulation; pregnant women; lactating; have skin burns, eczema or any other chronic skin disease; atopic individuals; present any metabolic disease; have any autoimmune disease; having had a vaccine up to two weeks before the start of the study or having the intention to have a vaccine while the study was being conducted; having already undergone chemotherapy treatment or being undergoing this type of treatment; making use of corticosteroid medications; make use of potentially photosensitizing drugs, such as thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides during the conduct of the experiment; individuals who are exposed to the intense sun frequently or who have been exposed to the intense sun in the last four months; individuals whose forearm skin has undergone procedures such as hair removal, chemical peels, dermabrasion or laser resurfacing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-7jvk8k	Development of teaching models for echocardiographic imaging planes in dogs and cats	Recruitment completed	Intervention	2020-05-04	<NULL>	<NULL>	3800	Development of Teaching Models for Imaging Planes Ecocardiographic in dogs and cats	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-03	Universidade Federal do Paraná	Departamento de Medicina Veterinária da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7jvk8k	<NULL>	Fourth year veterinary students who are attending the small animal medical clinic	Students who do not complete an hour of study in the models	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-83cwmx	Development of throw in healthy children	Recruiting	Observational	2017-05-15	<NULL>	<NULL>	1233	Development throw in typical children between 5 and 13 years	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-83cwmx	<NULL>	Participants included in the study: no dysfunction has history in the shoulder complex and present shoulder elevation range of motion of at least 150.	Will not be included in the study: participants with a history of rotator cuff surgery, fractures of the clavicle, scapula and humerus, systemic diseases involving the joints, cognitive deficits that prevent understanding commands to carry out the proposed task and injury that primarily affects the plexus brachial or central nervous system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-32m7jn9	Development of Virtual Environment for Learning about Syphilis in Primary Care: Teaching Tool with Health Science Student	Data analysis completed	Intervention	2026-03-05	<NULL>	<NULL>	8947	Construction and validation of a Clinical Simulation scenario for teaching syphilis management in Primary Health Care: a teaching tool for undergraduate health students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Potiguar	<NULL>	<NULL>	<NULL>	To be a regularly enrolled nursing student between the 5th and 7th semester; have at least 75% attendance in the course	Absence from any stage of the intervention or from the application of the instruments; being a scholarship holder or a collaborator of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-6ct969	Developmental assessment and stimulation of children at risk	Recruitment completed	Intervention	2016-12-14	<NULL>	<NULL>	1100	Assessment of child development and early intervention in high-risk children and their families in Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-15	Universidade Federal de Minas Gerais/Prof. Claudia Regina Lindgren Alves	Hospital Sofia Feldman	https://ensaiosclinicos.gov.br/rg/RBR-6ct969	<NULL>	They will be admitted newborns included in the House of the Hospital Sofia Feldman baby during the period of conducting the survey; which remained for at least three days in the House of Baby; whose families are willing to participate in the stages of this project and signed the term of free and informed consent.	Children whose parents did not sign the consent form and clear;  whose mothers died at birth;  whose mothers have mental disorders that compromise their understanding or following your child;  with diagnosed sensory disabilities;  with malformation of the nervous system or the locomotor system;  neurogenic diseases or chromosomal disorders diagnosed,  the presence of hypoxic-ischemic lesions (multicystic encephalomalacia or periventricular leukomalacia) diagnosed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-4n6rqyj	Device Development for a Diagnostic Procedure in Liver Diseases	Data analysis completed	Intervention	2023-02-02	<NULL>	<NULL>	5858	Development of a Device for Performing Biopsy Video-Assisted Liver	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Instituto para O Desenvolvimento da Educação Ltda.	Instituto para O Desenvolvimento da Educação Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-4n6rqyj	<NULL>	Patients with moderate to severe hepatic steatosis, submitted to abdominal laparoscopic surgery for another underlying disease; Patients who needed a liver biopsy for etiological confirmation or staging of disease activity	Refusal to participate in the study: Patients diagnosed with hepatocellular carcinoma (HCC) AND The following risk factors: Patients with INR &gt; 1.8 and/or platelets &lt; 70,000/mm3; Patients diagnosed with hepatocellular carcinoma (HCC); Patients with coagulopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-97579sk	Device replacement after jaw expansion in children	Recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7930	Evaluation of Retaines Replacement After Rapid Maxillary Expansion (RME) in Children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Faculdade de Odontologia da Universidade Estadual Paulista - Júlio De Mesquita Filho	Faculdade de Odontologia da Universidade Estadual Paulista - Júlio De Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-97579sk	<NULL>	Present Free and Informed Consent Ferm duly signed by your legal guardian; and sign the Free and Informed Consent Term; need for rapid jaw expansion; do not present periodontal involvement; do not present contraindications to the treatment itself; patients with incomplete maxillary bone maturation and transverse jaw deficiency; Patients of both genders (female and male); minimum age of 6 years and maximum of 12 years	Having previously performed maxillary expansion; not being included in the age criteria; patients who did not accept the treatment, as well as not signing the Free and Informed Consent Term and Free and Informed Consent Term; patients who have already performed the Rapid Maxila Expansion previously; bone consolidation of the median palatine suture; patients who have periodontal involvement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-2fxs983	Device training increases the volume of air entering the lung in individuals who have had Cardiac Surgery: what is the best way to regulate the device load	Recruitment completed	Intervention	2021-10-10	<NULL>	<NULL>	4959	Flow incentive inspirometer training in patients in the postoperative period of Cardiac Surgery: what is the best load prescription	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-2fxs983	<NULL>	Patients after cardiac surgery; both sexes; between forty and eighty years; had no postoperative complications; hospital discharge less than eight days.	Individuals unable to follow protocol; death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-10dv8yp2	Dexamethasone and Paracetamol with Codeine in Pain Control of Acute Dental Abscess: a randomized clinical trial	Not yet recruiting	Intervention	2023-05-08	<NULL>	<NULL>	6060	Dexamethasone and Paracetamol with Codeine in Pain Control of Acute Dentoalveolar Abscess in Evolution: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-10dv8yp2	<NULL>	Patients aged 18 to 55 years; diagnosis of acute dentoalveolar abscess in evolution; pain score equal to or greater than 40 mm in the Visual Analog Scale, at the time of initial care	Patients allergic to the drugs used in the present study; chronic use of opioids, steroid anti-inflammatories, antidepressants; history of liver disease; rheumatoid arthritis; severe heart disease; diagnosis of depression/anxiety; pregnant or lactating women; alcoholics; current or former users of substances such as crack, oxy, cocaine, marijuana and solvents; chronic pain; difficulties in understanding the scales	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-86mhm2	Dexamethasone effect on the duration of interescalenic brachial plexus block guided by ultrasound for videoarthroscopic shoulder surgery	Recruitment completed	Intervention	2016-04-05	<NULL>	<NULL>	3227	Dexamethasone effect on the duration of interescalenic brachial plexus block guided by ultrasound for videoarthroscopic shoulder surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-12-03	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-86mhm2	<NULL>	patients submitted to videoarthroscopy shoulder surgery	patients under 18 years old, previous history of allergy to any used medication in the procedure and diabetes (because of potential hyperglicemia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-9y2nn2	Diabetes and exercise	Not yet recruiting	Intervention	2017-03-14	<NULL>	<NULL>	1253	Type 2 diabetes and exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Universidade Federal do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes - HUOL	https://ensaiosclinicos.gov.br/rg/RBR-9y2nn2	<NULL>	Age between 30 and 70 years; body mass index between 25.0 and 39.9 kg/m2; diagnosis of type 2 diabetes for a period equal or greater than 1 year; insufficiently active or sedentary	Clinically unstable Diabetes (change in medication within the last two months); insulin-dependent; history of stroke, neuropathy or advanced retinopathy; pregnant or suspected pregnancy; contraindication for magnetic resonance imaging, according to the list available at: http://www.mrisafety.com/; severe musculoskeletal problems that limit the practice of physical activity; health problems that may interfere with the study protocols or safety during exercise; classified as &quot;risk&quot; for cardiovascular diseases; not submitting medical authorization to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-29gj42	Diabetes Management from Information Transmitted by Phone Calls	Not yet recruiting	Intervention	2013-07-17	<NULL>	<NULL>	216	Control of Type 2 Diabetes Mellitus: Analysis of an Intervention Program with Information about the Disease Via Phone Calls	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2013-09-09	Universidade Federal do Ceará - Departamento de Enfermagem	Universidade Federal do Ceará - Departamento de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-29gj42	<NULL>	Having type 2 diabetes for at least one year;Having more than 18 years old;Owning telephone contact;Being able to come to the unit for blood collection;Being able to self-monitoring of blood glucose and self-administration of medicines;Being able to understand the goals, methods and treatment procedures.	Owning hemoglonina glycated less than 7%;Have complications from the disease: kidney failure, blindness and amputation of limbs;Submit severe cardiovascular disease, high blood pressure or mental illness;Be participating in research with similar goals, made by other researchers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-8854cd	Diabetic Foot Care	Data analysis completed	Intervention	2013-07-16	<NULL>	<NULL>	214	The Use of Exercises and Instructions for Self-care in Diabetic Patients	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-12-16	Universidade Federal de Alfenas- UNIFAL-MG	Prefeitura Municipal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8854cd	<NULL>	Volunteers of both sexes, with a clinical diagnosis of type 2 diabetes for more than 5 years, with a minimum age of 30 years and maximum 85 years in routine medical monitoring in a Basic Health Unit in the city of Alfenas	Volunteers with some neurological disorders that produce balance disorders, with a history of alcoholism, herniated disc, leprosy, injuries and amputations of lower limbs, subject to inability to participate in all testing and training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-478w7y9	Diabetic foot prevention: educational activity for nursing students	Recruitment completed	Intervention	2021-03-18	<NULL>	<NULL>	4576	Simulation Intervention: Effectiveness to prevent  diabetic foot	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-12-05	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-478w7y9	<NULL>	The study will include nursing students regularly enrolled and who have already attended the disciplines of Technical Bases of Nursing Care, Semiology and Semiotechnics Applied to Nursing, Adult and Elderly Health, as these disciplines address the thematic physical examination, technical nursing and diabetes mellitus.	Academics with course locking, health and maternity leave will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-5p2xqqr	Diabetic neuropathy and recurrent laryngeal nerve involvement in patients undergoing thyroid surgery: evaluation of 50 cases	Data analysis completed	Observational	2025-09-29	<NULL>	<NULL>	8325	Comparative study between the values of recurrent laryngeal nerve latency in diabetic and non-diabetic patients undergoing thyroidectomy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-5p2xqqr	<NULL>	Volunteers of both sexes; age between 18 and 80 years; with or without a diagnosis of Diabetes; undergoing Elective Thyroidectomy Surgeries; laboratory tests collected within 90 days of the date of Surgery; signing of the informed consent form	Volunteers with comorbidities that could interfere with glycated hemoglobin values, such as Sickle Cell Anemia or Iron Deficiency; Blood Transfusion in the last year; Dialysis in the 90 days prior to the Surgical Procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-9y4nwm7	Diagnosis and treatment of Pneumonia in patients using a mechanical respirator, using the Molecular Biology technique	Recruiting	Intervention	2023-02-08	<NULL>	<NULL>	5887	Diagnosis and treatment of Pneumonia in intubated patients with Molecular Biology Method compared to diagnosis standard: prospective, controlled, and randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-02	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9y4nwm7	<NULL>	Patients under mechanical ventilation; both genders; over 18 years old; pneumonia	High probability of death within 24 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-102v5xpf	Diagnosis variability in psychiatry secondary to medical evaluation strategy.	Not yet recruiting	Intervention	2021-02-11	<NULL>	<NULL>	4542	Comparing diagnosis in mental health with different modes of interview.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Universidade Federal do Rio de Janeiro - Instituto de Psiquiatria da UFRJ	Faculdade de Medicina da Universidade de Lisboa	https://ensaiosclinicos.gov.br/rg/RBR-102v5xpf	<NULL>	"Patients: Being under the assistance of the same doctor or assistant group for, at least, one year. Agreeing to participate and signing the free and informed consignment term.
Doctors:Agreeing to participate and signing the free and informed consignment term."	Subjects in mutism, intense negativism, with incomprehensible discourse or so agitated that is incapable to be submitted to a diagnose interview.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-4bdbpk	Diagnostic and treatment of skin cancer lesions using Photodynamic Therapy - a less invasive technique than surgery with the application of a medication that interacts with light	Data analysis completed	Intervention	2019-04-22	<NULL>	<NULL>	2624	Diagnostic and treatment of skin cancer using Photodynamic Therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-24	Hospital Amaral Carvalho	Instituto de Física de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4bdbpk	<NULL>	patients of both sexes; older than 18 years;  present malignant lesions of the basal cell carcinoma nodular subtype (according to the International Classification of Diseases ICD 10, code D04.9) with a maximum diameter of two (2) centimeters (initial lesions); patients with multiple lesions may also be treated, provided that each lesion fits the characteristics described in the previous item; patients with impaired neurological or judgmental capacity may be included as long as the responsible relative for their care signs the consent term.	patients allergic to any of the excipients present in the formula; infiltrative basal cell carcinoma  subtype histological micro-infiltrative, sclerodermiform, and flat-cicatricial, terebrante, as well as squamous cell carcinoma or epidermoid carcinoma and melanoma; patients with porphyria; nodular lesions  of basal cell carcinoma with more than 2 cm in diameter; patients under 18 years of age; pregnant and lactating women; women of childbearing age; patients with photosensitive diseases, for example, lupus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-6p8pkvq	Diagnostic exam for renal cancer	Recruiting	Observational	2023-07-26	<NULL>	<NULL>	6275	Prospective evaluation of the use of PET/CT with 18 F-PSMA in kidney cancer	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-01	Fundação Antônio Prudente - AC Camargo Cancer Center	Fundação Antônio Prudente - AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-6p8pkvq	<NULL>	Patients aged at least 18 years; both genders; with histopathological diagnosis of renal cancer, clear cell or papillary subtypes	None	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-88b5jr	Diagnostic study of Dengue in Emergency Care	Recruiting	Intervention	2014-09-11	<NULL>	<NULL>	333	Pragmatic Diagnostic Trial  of Cinical-Laboratory Algorithm for Dengue in Emergency Care Units in Rio de Janeiro	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-05	Conselho Nacional de Desenvolvimento Científico e Tecnológico (	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-88b5jr	<NULL>	Patients of both genders over 18 years assisted in Emergency Care Units in Rio de Janeiro, with fever for up to 3 days without other infectious etiology.	pediatric patients and those with other infectious etiology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-7fhzpwd	Diamond Peeling Effectiveness Evaluation associated with Vitamin C in Melasma lightening and reduction: a pilot study	Recruitment completed	Intervention	2021-10-15	<NULL>	<NULL>	4992	Microdermabrasion Effectiveness Evaluation associated with Vitamin C in Melasma lightening and reduction: a pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-02	Faculdade Ciências Médicas de Minas Gerais	Faculdade Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7fhzpwd	<NULL>	Female participants; aged 20 to 60 years; phototype of grade II, III or IV; epidermal melasma	Pregnant women; lactating women; people with a history of hypertrophic scars and/or keloids; who are undergoing or have already undergone any dermatological treatment in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-66sfk5k	Diastáse em Mulheres	Recruitment completed	Intervention	2024-12-18	<NULL>	<NULL>	7607	Diastasis of the abdominal muscles in women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-10	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-66sfk5k	<NULL>	Women aged 18 or over; were pregnant; with diastasis from 2 cm; no previous abdominal aesthetic surgeries; no musculoskeletal disease	Pregnant women; Women diagnosed with a hernia in the midline of the abdomen; Obese	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-10nhhm4v	Diet and blood Magnesium, Selenium, Folate, Omega-3 and Omega-6 levels in patients with chronic facial pain	Not yet recruiting	Observational	2026-02-26	<NULL>	<NULL>	8921	Food intake and serum levels of Magnesium, Selenium, Folate, Omega-3 and Omega-6 in patients with Chronic Painful Temporomandibular Dysfunction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-05	Departamento de Odontologia Restauradora da Universidade Federal do Ceará Campus Fortaleza	<NULL>	<NULL>	<NULL>	The volunteers will be female; aged between 20 and 45; seeking treatment at the Dentistry course at the Federal University of Ceará; as well as from the general population, recruited through social media and posters; present painful complaints of at least 5, measured on a Numerical Scale ranging from 0 (no pain) to 10 (worst possible), for at least 3 months and with no history of previous treatment for at least three months; the healthy group will consist of women without Temporomandibular Disorders and with no previous history of facial pain complaints	Women with previously diagnosed disabling cognitive, psychological, and neurological disorders;  in addition to a previous diagnosis of chronic kidney disease, liver disease, megaloblastic anemia, or cancer, other chronic painful disorders; abuse of legal drugs and/or alcohol, use of illegal drugs; pregnant and lactating women; volunteers who had lost five or more teeth, poorly fitting dentures, severe periodontal disease, toothache, intraoral or extraoral lesions capable of compromising masticatory function; use of multivitamins or isolated supplements containing magnesium or selenium in the last 30 days; those with systemic conditions likely to cause dietary restrictions, such as lactose intolerance, gluten intolerance, diabetes mellitus, severe irritable bowel syndrome, and inflammatory bowel disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-2gcb7ht	Diet and pain in women with Temporomandibular Disorder (TMD)	Not yet recruiting	Observational	2025-10-06	<NULL>	<NULL>	8361	Dietary profile of women with chronic Temporomandibular Joint Disorder	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2gcb7ht	<NULL>	a pain complaint with a minimum intensity of 5, measured by a numerical pain scale ranging from 0 (no pain) to 10 (worst possible pain), with the main pain in the temporomandibular joint region and no previous treatment in the last three months; the healthy group will consist of women without a diagnosis of temporomandibular dysfunction and without a history of facial pain	women with previously diagnosed incapacitating cognitive, psychological or neurological alterations; other chronic pain disorders; abuse of licit drugs or alcoholic beverages; use of illicit drugs; heart disease; pregnant and lactating women will be excluded; volunteers with loss of five or more dental elements; ill-fitting prostheses; severe periodontal disease; odontalgia; intra- or extra-oral lesions that compromise masticatory function; food intolerances; diabetes mellitus or other systemic conditions that may lead to food restriction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-3p2vc2	Diet and risk of chronic diseases among college students	Recruitment completed	Intervention	2015-05-28	<NULL>	<NULL>	489	Food consumption as a risk factor for chronic diseases among university students: prevalence and nutritional intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3p2vc2	<NULL>	Inadequacies in food consumption	Not have completed a total of 3 units of food records before the start of the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-3nvsj3z	Diet that mimics Fasting in patients with Breast Cancer treated by SUS: effects on reducing the effects caused, quality of life, progression, metastasis and tumor sensitization	Not yet recruiting	Intervention	2021-10-21	<NULL>	<NULL>	4995	Impact of implementing a Nutritional Protocol that Mimics Fasting in Breast Cancer patients treated by SUS: a proposal on reducing side effects, quality of life, progression, metastasis and tumor sensitization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3nvsj3z	<NULL>	Female patients have a histologically confirmed diagnosis of HER2-negative, early stage II/III breast cancer (cT1cN + or ≥T2 any cN, cM0), and who have not yet started chemotherapy, adequate bone marrow; adequate liver function; adequate kidney function; normal heart function; age ≥18 years; BMI&gt; 19 kg/m2; absence of diabetes mellitus; absence of allergy to MJD and signed consent form.	Previous 5-year malignancy, with the exception of a history of previous basal cell carcinoma of the skin or pre-invasive carcinoma of the cervix; presence of other serious diseases, such as recent myocardial infarction, clinical signs of heart failure or clinically significant arrhythmias; BMI &lt; 19 kg/m2; patient with severe weight loss; pregnancy or breastfeeding; significant food allergies that would make the subject unable to consume the food provided; medical or psychological condition that, in the investigator&apos;s opinion, would not allow the patient to complete the study or sign a meaningful informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-6gh6s9	Dietary intervention in metabolic syndrome and its association with the genetic profile of lactose intolerance	Recruiting	Intervention	2019-12-19	<NULL>	<NULL>	3298	Influence of lactose-free diet on metabolic syndrome: role of polymorphisms in the genes for lactase, adiponectin and its receptor, GIP and its receptor, TCF7L2, TNF-alpha, IL-6 and NFK-B	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade do Estado da Bahia	Associação de Pais e Amigos dos Excepcionais (APAE)	https://ensaiosclinicos.gov.br/rg/RBR-6gh6s9	<NULL>	Volunteers diagnosed with metabolic syndrome based on the criteria proposed by the International Diabetes Federation (IDF, 2006); both genders; age range from 20 to 80 years old; signature of the informed consent form (ICF).	Patients with inflammatory bowel disease (Crohn&apos;s disease, ulcerative colitis, irritable colon and diverticulitis); with chronic renal failure; with chronic liver disease (with the exception of hepatic steatosis); taking medication for appetite control, hypoglycemic, hypolipidemic or anxiolytic/antidepressant; with autoimmune diseases and/or taking corticosteroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-5kbzdh	Dietary supplementation with Omega in pregnant and the placentary vascular resistance assessed through the doppler of the uterine arteries	Not yet recruiting	Intervention	2018-06-19	<NULL>	<NULL>	3086	Dietary supplementation of Omega 3 and the participation in the placentary vascular resistance mechanism in pregnant people: a comparison with normal pregnant women without use of Omega, chronic hypertensions in use of AAS and  pregnants with thrombophilia and use Heparina or  AAS	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Medicina de Barbacena	Faculdade de Medicina de Barbacena	https://ensaiosclinicos.gov.br/rg/RBR-5kbzdh	<NULL>	"Pregnant women enrolled in prenatal care of the institution.
Pregnant women who signed the free and informed consent form.
Pregnant women who attend the appointments (with even a missed prenatal) and agree to perform the protocol of the service, clinical examinations and imaging.
Pregnant women with hereditary or acquired thrombophilias identified
previously.
Pregnant women with identified risk factor for preeclampsia or CIUR selected from ACOG and NICE data adapted for this study:
i. Identification of two anamnesis clinical data (clinical history of PE in previous pregnancy, history
PE in first-degree relative, BMI&gt; 35 kg / m2, hypertension, nephropathy, disease
autoimmune).
ii. Identification of anamnesis clinical data associated with changes in uterine artery doppler in the
first trimester (IR, PI or bilateral doppler notch).
iii. MAP identification&gt; 100 in the first trimester of pregnancy associated with clinical history or Doppler
altered uterine artery (PI, IR, uterine artery notch)."	"Pregnant women - under 19 years.
Pregnant women who are absent from consultations - two or more consecutive prenatal absences.
Pregnant women who do not accept to use the omega in the prenatal or have intolerance to the use of the omega.
Smoking patients.
Gestantes without risk factor or thrombophilia."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-53hjzk	Diferent doses of lactase in subjects with intolerance lactose	Recruiting	Intervention	2016-09-09	<NULL>	<NULL>	2857	Clinical trial for the evaluation of the efficacy and safety of lactase different oral dosages upon intestinal symptoms and hydrogen breath excretion in patients with hypolactasia	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-04-15	Nutracom Indústria e Comércio Ltda.	Instituto Claudia Marques de Pesquisa e Desenvolvimento Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-53hjzk	<NULL>	"Volunteers diagnosed with lactose intolerance;
Volunteers with genotype CC - not persistent Lactase (intolerance to lactose); Volunteers of both sexes (male or female) aged 18-55 years; BMI between 18.5 and 30 kg / m2; Good health or without significant disease, the medical judgment, in accordance with the rules set out in the protocol; Able to understand the nature and purpose of the study."	"Volunteer known to have hypersensitivity reaction known to the study of the product (lactase) or the formulation excipients including lactose; maintenance therapy for use with any drug that interacts with lactase or interferes in the results of the breath test, except for contraceptives; Treatment with laxatives, antibiotics, prokinetic (eg, metoclopramide, domperidone, cisapride and others.), Or any drugs known to influence the colonic flora or gastrointestinal motility in the month prior to the study;
Use Vitamins and dietary supplements;
History or presence of liver, renal, pulmonary, cardiac, neurological or metabolic diseases; Malignancies; organic gastrointestinal diseases; secondary hypolactasia; reported anemia or proven from the results of laboratory examination of blood count; Giardiasis and strongyloidiasis proven from the results of laboratory parasitological examination of stool; Diabetes reported or confirmed; Hypoglycemia proven from the results of laboratory examination of plasma glucose: below 55 mg / dl for men and 45 mg / dl for women;
Diseases which cause damage in the intestinal mucosa, diseases that significantly increase the gastrointestinal transit as infectious enteritis, celiac disease, inflammatory bowel disease (Chron), drug-induced enteritis or radiation, diverticular disease of the colon; History of surgery: heart (whatever), renal (exercises kidney or renal agenesis), intestinal (partial or total removal of the esophagus, stomach, duodenum, jejunum, ileum, ascending colon, transverse colon, descending colon, sigmoid colon or rectum) , liver or pancreas; Volunteers smoking more than five cigarettes a day; different eating habits of the population standard, eg vegetarianism, veganism; History of alcohol consumption or use of drugs of abuse; Made use of antibiotics as regular medication (continuous use) within the 4 weeks preceding the valuation date and / or the start of the breath test; This examination Colonoscopy one month before the breath test H2 expired. After the intestinal flora colonoscopy need to 4 weeks to recover; Use of antiparasitic drugs in the 30 days preceding the breath test H2 expired. Held bowel tests, for which intestinal cleaning was done; Participation in a clinical trial in the last 12 months before the beginning of the study; Diarrhoea on the H2 breath test expired; The volunteer has any condition that prevents him from participating in the study by the judgment of the physician clinical researcher; positive pregnancy test."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-8k2tq29	Differences between dentures made the traditional way and those made with 3D printing	Not yet recruiting	Intervention	2026-03-04	<NULL>	<NULL>	8942	Conventional complete dentures vs. 3D-printed complete dentures	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Participants who have been completely edentulous for at least 1 year; individuals seeking oral rehabilitation at the complete denture service at the Faculty of Dentistry of Pernambuco (FOP/UPE); participants who agree to participate in this research by signing the Informed Consent Form; participants over 18 years of age; both sexes; participants classified as class 1 or class 2 in the Dental Prosthesis Diagnostic Index for complete edentulism; participants with sufficient systemic health to attend clinical appointments and the discernment to answer the questionnaires	Individuals with retentive ridges (indication for surgery); individuals with neoplastic and non-neoplastic proliferative processes in the oral mucosa; individuals with alterations in the oral mucosa resulting from microbial infections; individuals with neuromuscular disorders.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-9crqgt	Differences between two types of nutritional education programs	Recruitment completed	Intervention	2019-10-10	<NULL>	<NULL>	3066	Internet - based nutrition education versus conventional nutrition education: A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal de Alagoas	Instituto Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-9crqgt	<NULL>	Age between 10 years and 19 years; students from Ifal Murici and Satuba campus; students from Monsenhor Clóvis Duarte de Barros State School, União dos Palmares	Inability to perform anthropometric measurements; special needs; pregnant or nursing; patients with acquired immunodeficiency syndrome; patients of type I diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-8q58cj	Different application times of myofascial release on anterior thigh muscle strength	Recruitment completed	Intervention	2019-10-09	<NULL>	<NULL>	3056	Effect of different duration times of application of myofascial release on quadriceps femoris strength: A randomized experimental study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-14	Julio Guilherme Silva	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-8q58cj	<NULL>	"Men between 18-35 years old; physically active; verified by the
international physical activity questionnaire (IPAQ)"	Lower limbs post-operative history in the last 12 months; unconsolidated fractures in the lower limbs; respiratory or cardiovascular diseases considered to be risky or limiting factor for the strength test; lower limb and/or lower back pain during the tests and difficulty performing the requested procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-8fp63gm	Different follow-up models for the treatment of obesity in adolescents	Recruiting	Intervention	2022-01-03	<NULL>	<NULL>	5134	Effects of different intervention models for the treatment of obesity in adolescents	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Laboratório Interdisciplinar de Intervenção em Promoção da Saúde (LIIPS)	Instituto Cesumar de Ciência, Tecnologia e Inovação	https://ensaiosclinicos.gov.br/rg/RBR-8fp63gm	<NULL>	As inclusion criteria, adolescents with the following characteristics will be accepted: a) present between 12 and 17 years of age; b) being overweight or obese within the cutoff ranges and c) being available to participate in theoretical-practical interventions 3x a week (on Mondays, Wednesdays and Fridays) for 14 weeks, that is, 1 week of assessments, 12 weeks of interventions and 1 week of reassessments.	Exclusion criteria will be: a) use of glucocorticoids and/or psychotropic medications that can be used regularly; b) frequency of less than 75% in the different theoretical-practical activities that will be practiced; c) osteomyoarticular limitations that prevent the regular and systematic practice of physical exercises. at the time any teenager decides to participate in another nutritional guidance program or other physical exercise proposals, as well as decide to start a diet, low in calories, low in carbohydrates or low in fat, they will not be included in the statistical analyses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-103g7j28	Different local anesthesia and photobiomodulation on the surgiers of third molars extraction	Recruiting	Intervention	2023-12-07	<NULL>	<NULL>	6739	Analysis of different local anesthesia and photobiomodulation on the surgiers of third molars extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-103g7j28	<NULL>	Over 18 years of age, have good oral hygiene (plaque index &lt; 20%), have all four third molars and have indication for dental extraction of all third molars	Patients with periodontal disease, patients with systemic diseases or conditions or who use drugs that alter bone metabolism (except diabetics), decompensated diabetics (glycated hemoglobin above 8%), pregnant or lactating women, heavy smokers (above of 10 cigarettes daily), presence of periapical lesions, presence of pericoronitis lesions, patients allergic to penicillins	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-9nqszr	Different materials for the Atraumatic Restorative Treatment technique in deciduous teeth, a clinical investigation	Recruitment completed	Intervention	2017-08-24	<NULL>	<NULL>	2838	"Randomized double blind clinical trial using different materials on teeth
By ART technique: three years of follow-up"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9nqszr	<NULL>	"Healthy volunteer children; Both genders;
Duly enrolled in municipal or state schools;
With an acceptable oral hygiene level; With
a minimum of 4 years and a maximum of 9
years."	"Children who do not accept oral examination or restoration; Those that are missing on the scheduled restoration day; Those whose managers do not sign the Free and Informed Consent Form; Teeth with very deep carious lesions; Fistulated
teeth; With such spontaneous pain."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-4qdx3v	Different materials for the technique of Atraumatic Restoration in deciduous teeth of children, a clinical investigation with 3 years of follow-up	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2911	Randomized double blind clinical trial using different materials in deciduous teeth of children by the ART technique: two years of follow-up	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-07	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4qdx3v	<NULL>	Healthy Volunteer Children; both genders; duly enrolled in municipal schools; with an acceptable oral hygiene level; with a minimum of 4 years and a maximum of 9 years	Children who are missing on scheduled restorations day; those responsible do not sign the Free and Informed Consent Form; children who do not accept by bad behavior the oral examination or the realization of the restorations; teeth with very deep carious lesions; fistulated teeth; with such spontaneous pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-3b2g2y	Different semantic frequencies of pelvic floor muscle training for women with stress urinary incontinence	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3305	Different weekly frequencies of pelvic floor muscle training for women with stress urinary incontinence: a ramdomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal de São Carlos	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-3b2g2y	<NULL>	Being a woman (biological); Age 18 years and over; complain of stress urinary incontinence determined by the affirmative response to involuntary urine loss associated with coughing, sneezing, exercise or weight lifting in the last month.	Latex allergy; vaginal or urinary tract infection; virginity; being in the gestational period; being in the puerperal period; complain of neurological disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-7b4whmz	Different teaching strategies about patient safety goals for nursing and medicine students	Recruiting	Intervention	2024-09-23	<NULL>	<NULL>	7367	Assessment of the effectiveness of different teaching strategies on patient safety for nursing and medicine students in primary health care: randomized controlled study	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-11-24	Faculdade de Medicina da Universidade Federal de Juiz de Fora	Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7b4whmz	<NULL>	Volunteer students who must be regularly enrolled in the 9th period of the medicine and nursing course at the Federal University of Juiz de Fora; be over 18 years of age; both sexes;  and agree to participate in the study	Students from both courses who are absent; licensed or on leave during the data collection period and who do not sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-38fknk	Different Techniques for Lung Ventilation During Cardiac Surgeries	Recruiting	Intervention	2013-07-03	<NULL>	<NULL>	202	Assessment Alveolar Recruiting During Heart Surgeries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-15	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-38fknk	<NULL>	Age between 19 and 90 years. Ambos sexes. Cirurgia elective coronary artery bypass grafting with or without associated procedures. Surgery of exchange and valvuloplasty. Cirurgia of aneurysms of the ascending aorta and aortic arch. Pacientes who agreed to participate in the study by signing the consent form.	Age less than 19 years or greater than 91 years. Urgent surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-24fcn7p	Different times of administration of Pantoprazole on the control of heartburn in patients with Gastroesophageal Reflux	Recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5869	Effect of Pantoprazole Sodium before lunch versus before breakfast on the control of heartburn in patients with Gastroesophageal Reflux Disease: a pilot study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-10-13	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-24fcn7p	<NULL>	Age greater than or equal to 18 years; both genders; body mass index between 18.5 and 39.9 kg/m2; chief complaint of heartburn (current if not on treatment or controlled with proton pump inhibitor); diagnosis of sliding hiatal hernia (2 cm or more) confirmed by digestive endoscopy	Not having at least three meals a day regularly, including breakfast, lunch and dinner; cognition and communication difficulties; esophagogastric surgery of any nature; pregnant and lactating women; women in the fertile period without using a contraceptive method; alcohol or tobacco abuse (&gt;10 cigarettes/day); decompensated systemic disease (arterial hypertension, diabetes mellitus, cirrhosis, chronic renal failure, lung disease and any infectious condition); not having heartburn after 5 days of discontinuing the proton pump inhibitor (PPI), if using it	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-649gzcs	Different types of approaches focused on the well-being of patients with knee osteoarthritis	Recruitment completed	Intervention	2026-04-16	<NULL>	<NULL>	9110	Biopsychosocial Approach strategie in Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-04-01	Universidade São Francisco	<NULL>	<NULL>	<NULL>	Participants must be between 35 and 75 years old; of either sex; have osteoarthritis of the knee joint (unilateral or bilateral) lasting at least 2 years to ensure the chronic nature of the disease; and present pain greater than 4 on the Numerical Pain Scale in 3 of the following actions: climbing and descending stairs; kneeling, sitting and standing; running; and standing for 2 minutes	Participants will not be included in the study if they present any type of contraindication to exercise; severe cardiorespiratory disease; untreated hypertension; uncontrolled diabetes mellitus; motor or sensory neurological deficits; frequent physical activity; fibromyalgia; rheumatoid arthritis; require a walking aid; recent hyaluronic acid injection and/or any type of invasive therapy; or refuse to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-5r2rtb	Different types of strengthening in women with patellofemoral pain syndrome	Recruiting	Intervention	2019-02-28	<NULL>	<NULL>	4229	Influence of core muscles in women with Patellofemoral Pain Syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-12	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5r2rtb	<NULL>	Pain at least for a month. No relation with accident. Insidious onset. Positive tests for patellofemoral pain. Female. Between 18 and 30 years old.	Specific diseases of the knee. Knee surgery. Knee treatments or physiotherapy during the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5kjjw52	Difficulties and assessment of maternal confidence with breastfeeding: randomized controlled clinical trial	Recruitment completed	Intervention	2026-05-01	<NULL>	<NULL>	9161	Challenges and assessment of maternal self-efficacy with breastfeeding: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-05	Universidade Federal de Sergipe- Campus Lagarto	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; be literate; be at least 28 weeks pregnant; have at least one telephone contact	Postpartum women who, after giving birth, are not in a position to breastfeed and/or who are unable to breastfeed for more than 24 hours; postpartum women with diagnosed mental disabilities/disorders and language or speech disorders with  International Classification of Diseases (ICD), who have significant difficulties in verbal communication to understand and/or respond adequately to questions during interviews	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-8dyxv8k	Digital care lines in guidance on positive childbirth experience: health education on fear of childbirth through Information and Communication Technologies	Recruitment completed	Intervention	2024-09-18	<NULL>	<NULL>	7354	Digital care lines in guidance on positive childbirth experience: use of Information and Communication Technologies in reproductive health education. Intervention on fear of birth through knowledge of the physiological processes involved in parturition and humanized practices in childbirth care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-03	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP - HCFMRP	Centro de Referência de Saúde da Mulher de Ribeirão Preto - CRSMRP- Mater	https://ensaiosclinicos.gov.br/rg/RBR-8dyxv8k	<NULL>	Pregnant women with at least one office visit in the pre-natal service of Women&apos;s Health Reference Center of Ribeirão Preto – MATER; informed consent form signed if age at least 18 years old or assent form signed if younger than 18 years old (in this case, with a consent form signed by legal guardian)	Patients that do not have access to a mobile phone with internet connection and access to the free messaging app Whatsapp; clinical conditions that impair the comprehension of the videos (such as alcohol and/or drug addiction, psychiatric diseases without adequate medical treatment)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-6c7ghfd	Digital care program for older adults with depressive symptoms in primary care	Recruiting	Intervention	2021-10-21	<NULL>	<NULL>	4997	Digital care program for older adults with depressive symptoms in primary care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Faculdade de Medicina da Universidade de São Paulo	King's College London	https://ensaiosclinicos.gov.br/rg/RBR-6c7ghfd	<NULL>	Registered with one of the participating clinics or organisation; aged 60 or over; scores of PHQ-2 higher than 0 (first two questions of PHQ-9) and PHQ-9 between 5 and 9; able to receive live calls and WhatsApp messages (audio and images) on a mobile phone	Unable to communicate (non-Portuguese speaking, cognitively impaired or other problem hindering communication to engage in trial assessment and intervention such as vision or hearing problems, terminal illness or severe mental illness); individuals presenting suicidal risk during the two weeks prior to the screening assessment, as assessed by the 9th item of the PHQ-9 and Immediate Suicide Risk Protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3yt263y	Digital health interventions based on app for cell phones or e-book for health promotion	Recruiting	Intervention	2021-05-12	<NULL>	<NULL>	4644	DIGITAL INTERVENTIONS: Actions to promote health and adhere to treatment for patients undergoing psychiatric follow-up.	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade  Estadual de Londrina	Clinica neuropsiquiatrica Palhano	https://ensaiosclinicos.gov.br/rg/RBR-3yt263y	<NULL>	The inclusion criteria for the participants will be: being recruited by outpatient clinics for adolescents and for mental disorders; be between 14 and 65 years old;have a telephone with an internet connection available; understand instructions on using the app.	The exclusion criteria for participation in the research will be: cognitive deficit that does not allow the understanding of the free and informed consent term and the understanding of instructions for using the app; problems or inability to operate a smartphone touchscreen.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-5ghn5f4	Digital intervention based on self-compassion for the prevention of mental health in Brazilian university students	Recruiting	Intervention	2022-11-23	<NULL>	<NULL>	6776	Development, evaluation and effectiveness of an mHealth-type intervention based on Compassion-Focused Therapy for mental health prevention among Brazilian university students	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-09	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5ghn5f4	<NULL>	Be enrolled in a face-to-face course; basic knowledge of the use of smartphones; have a smartphone with internet access and Android or IOS operating system; at least mild depressive, anxiety or stress symptoms	Have a diagnosis of a severe and persistent mental disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-4c94dtn	Digital psychosocial intervention for older adults with depression	Recruiting	Intervention	2021-10-22	<NULL>	<NULL>	4999	Digital psychosocial intervention for older adults with depression	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Faculdade de Medicina da Universidade de São Paulo	King's College	https://ensaiosclinicos.gov.br/rg/RBR-4c94dtn	<NULL>	Registered with one of the participating clinics or organisations; aged 60 or over; scores of PHQ-2≥1 (first two questions of PHQ-9) and PHQ-9≥10; able to receive live calls and WhatsApp messages (audio and images) on a mobile phone.	Unable to communicate (non-Portuguese speaking, cognitively impaired or other problem hindering communication to engage in trial assessment and intervention such as vision or hearing problems, terminal illness or severe mental illness); individuals presenting suicidal risk during the two weeks prior to the screening assessment, as assessed by the 9th item of the PHQ-9 and Immediate Suicide Risk Protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-7drnzt	Diminution of fasting in cirurgia using carbohydrate.	Data analysis completed	Intervention	2015-06-01	<NULL>	<NULL>	494	Comparison of parameters of respiratory strength in postoperative elective cholecystectomy by laparotomy when respected conventional fasting and 2 hours fasting.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Federal do Mato Grosso - UFMT	CAPES- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-7drnzt	<NULL>	Patients with an indication for cholecystectomy by laparotomy and rachianesthesia; aged 18 to 60 years; with body mass index (BMI) ranging from 18.5 to 29.5 kg/m²; ASA I and II and Subjective Global Assessment (SGA) A.	Requiring  cholecystectomy with bile duct exploration; patients who underwent surgery with operative time greater than 120 minutes or whose anesthesia had to be converted to general anesthesia; needing immediate surgical reintervention; patients with complications in the postoperative period; pregnant patients and those with diabetes; hypertension; lung disease; heart disease; arthritis and gastroesophageal reflux disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-3sdgfyy	Dipyrone for the acute treatment of Dialysis Headache	Not yet recruiting	Intervention	2023-06-07	<NULL>	<NULL>	6141	Evaluation of Dipyrone in the acute treatment of Dialysis Headache: a randomized, double-blind, placebo-controlled study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-06-30	Pós Graduação em Neuropsiquiatria e Ciências do Comportamento - Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3sdgfyy	<NULL>	Patients of both genders; aged 18 years or over; on hemodialysis treatment for chronic renal failure; diagnosed with dialysis headache according to the criteria of the International Classification of Headache Disorders (ICHD-3); who experience this headache during dialysis	Patients who have a known diagnosis of Acute Chronic Renal Failure; patients who are allergic to dipyrone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-107wv6d9	Dique Filipéia Rehabilitation Protocol for patients with COVID-19	Recruiting	Intervention	2021-07-07	<NULL>	<NULL>	4782	Evaluation of the Implementation and Effectiveness of the (Dique Filipéia) Physiotherapy Protocol in COVID-19 patients admitted to the Municipal Health Network in the city of João Pessoa	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Laboratório de Estudos do Treinamento Fisico Aplicado a Saúde /Universidade Federal da Paraíba	Secretaria de Saude do Município de João Pessoa, PMJP	https://ensaiosclinicos.gov.br/rg/RBR-107wv6d9	<NULL>	COVID-19 patients in care at health units and admitted to hospitals; both sexes.	Mechanically ventilated critically ill patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-24tf9n	Direct current neuromodulation and its benefits in different populations	Data analysis completed	Intervention	2018-06-15	<NULL>	<NULL>	1902	Transcranial direct current stimulation and the  potential therapeutic approach in different populations	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-24tf9n	<NULL>	Participants were selected from a specialized outpatient service and regarded as suitable to participate in this study if they fulfilled the following criteria: clinical diagnoses of diabetic polyneuropathy; aged from 18 to 60 years; not lactating; no history of brain surgery, tumor, or intracranial metal implantation	Participants with any uncontrolled clinical disease, such as thyroid disease, cardiovascular, pulmonary, haematological or renal disease; alcohol or other substance abuse; pregnancy; lactation; neuropsychiatric disorders; history of epilepsy and metallic implants in the head were excluded. Patients with significant cognitive dysfunction were excluded. Patients were carefully evaluated by a physician	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-5fh5r4	Direct current neuromodulation and its benefits in different populations	Recruiting	Intervention	2018-12-04	<NULL>	<NULL>	2362	Transcranial direct current stimulation and its therapeutic potential in different populations	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-04	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5fh5r4	<NULL>	Man or woman aged 18 or older; be in chronic phase of chikungunya fever (least 3 month of the initial infection) and show laboratory tests or clinical diagnostic confirmation of chikungunya virus; pain related with more than 4 in a numeric rating scale; to have physical capacity to do physical evaluation and be capable of consenting to treatment and understanding study explanations and questionnaires; having provided informed consent	Electrical implants in the body; a history of epilepsy; people who are clinically contraindicated to receive tDCS such as having metal embedded in their scalp or brain; psychiatric illness, and history of drug abuse; pregnant women; signs of severity and/or indication of hospitalization; presence of previous rheumatic disease including gout, rheumatoid arthritis, fibromyalgia, lupus and others chronic pain syndromes with diagnosis prior to chikungunya	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-92pm68	Direct laryngoscopy or videolaryngoscopy intubation in patients without difficult airway predictors. Randomized Trial in Teaching and Training Center	Not yet recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3785	Direct laryngoscopy or videolaryngoscopy intubation in patients without difficult airway predictors. Randomized Trial in Teaching and Training Center	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Hospital Central do Exército	Hospital Central do Exército	https://ensaiosclinicos.gov.br/rg/RBR-92pm68	<NULL>	Patients over 18 years old; with pre-anesthetic physical status classification according to the American Society of Anesthesiology ( ASA) 1  or 2, that is,   without functional limitation  or slight limitation.	The following factors are considered exclusion criteria: refuse of the patient or guardian; cervical spine surgery; head and neck tumors or anatomical deviations of the airway; mandibular joint disease; cervical mobility restriction; coagulation disorders; morbid obesity and risk of bronchoaspiration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-7w2yvfp	Direct Tracks to correct Unilateral Crossbite in children	Not yet recruiting	Intervention	2025-01-16	<NULL>	<NULL>	7666	Planas Direct Tracks (PDT) compared with no intervention for correction of Functional Posterior Crossbites in children: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-17	Associação Brasileira de Odontologia secção Bahia	Associação Brasileira de Odontologia secção Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7w2yvfp	<NULL>	Children between 4-5 years of age, both sexes; who have Posterior Crossbites Functional; and do not yet have the first permanent molar erupted; posterior unilateral crossbite defined as minimum two crossed posterior teeth; deviation of mandibular position from contact in centric occlusion to position of maximum intercuspation accompanied by line deviation average of at least 1mm; perimeter compatibility between the arches, that is, in position centric relationship, the maxilla should not exceed the mandible by more than 2mm; children who have eliminated finger-sucking and/or pacifier habits due to fur least 6 months until the exam date; children whose parents sign an informed consent form after the carrying out the exams	Children with cleft lip and/or palate; syndromes or neurological diseases associated with craniofacial anomalies or dental ankylosis; children with anterior crossbite or class III skeletal relationship; previous orthodontic treatment; caries or extensive restorations, with mesio-distal or disto-vestibular involvement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-99xvpph	Discovery of proteins that differentiate health and disease around dental implants	Recruiting	Observational	2022-12-19	<NULL>	<NULL>	5768	The searching for novel biomarkers for the diagnosis of peri-implant diseases using proteomic approaches	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Estadual de Maringá	International Team for Implantology	https://ensaiosclinicos.gov.br/rg/RBR-99xvpph	<NULL>	Patients with one or more dental implants with at least 10 years in function treated at Dental Clinic of the State University of Maringá	Medical history that includes serious medical conditions or communicable diseases; Use of immunosuppressive drugs, bisphosphonates or steroids in the last 5 years; Antibiotic therapy or oral prophylactic procedures within the previous 3 months; Conditions that require prophylactic antibiotic coverage prior to dental treatment; Pregnancy or lactation; Subjects who underwent non-surgical treatment for peri-implant disease in the last 6 months; Subjects who underwent surgical treatment for Peri-implantitis in the last two years; Sites with implant-supported rehabilitations with little marginal adaptation and inadequate access to hygiene.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-7rk26hj	Discussion of the evaluation of the treatment of Partial Rupture of the Supraspinatus Tendon with the Needling technique associated with Platelet Rich Plasma	Data analysis completed	Intervention	2023-05-29	<NULL>	<NULL>	6117	Evaluation of the treatment of Partial Rupture of the Supraspinatus Tendon with the Dry Needling technique associated with Platelet Rich Plasma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-30	Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP	Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-7rk26hj	<NULL>	Patients of both sexes, aged over 25 years, with partial rupture of the supraspinatus less than or equal to 1 cm in the longitudinal axis evaluated by ultrasound.	Patients who underwent any ultrasound-guided needling procedure in the affected tendon, use of infiltration with corticosteroids in the affected shoulder in the last 6 months, presence of another pathology of the shoulder to be treated (fracture or arthritis of rheumatic origin), cervical spine radiculopathy, pregnancy, neoplasm, severe liver disease or nephropathy, autoimmune, inflammatory or infectious diseases, acute or chronic, hypersensitivity to lidocaine, use of anti-inflammatory drugs or corticosteroids in any form before 6 weeks of application of platelet-rich plasma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-7kfwfv	Disinfection efficacy of diode laser in root canal retreatment: a clinical trial with follow up	Data analysis completed	Intervention	2020-04-14	<NULL>	<NULL>	3747	Antimicrobial efficacy of 980 nm diode laser in root canal indicated to retreatment: a randomized trial with clinical and radiographic follow up	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7kfwfv	<NULL>	unirradicular tooth with periapical lesion 2 years; healthy patients	Patients with fractured teeth; perforation; root resorption; pregnant women and have received antimicrobial treatment in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7nzxkm	Distal transradial access (in the anatomical snuffbox) as default for cardiac catheterization and coronary angioplasties	Recruiting	Observational	2020-07-15	<NULL>	<NULL>	4010	Distal transradial access as default approach for coronary angiography and interventions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-02-12	Hospital Regional do Vale do Paraíba (HRVP)	Universidade Federal De São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-7nzxkm	<NULL>	Patients referred for coronary angiography or percutaneous coronary interventios with any (even weak) palpable pulses in both proximal (wrist) and distal (anatomical snuffbox).	Patient refusal or absence of palpable radial pulses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-9gdssk9	Distance-Oriented Exercises for patients with Cystic Fibrosis	Not yet recruiting	Intervention	2022-11-09	<NULL>	<NULL>	5713	Telerehabilitation of individuals with Cystic Fibrosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-30	Faculdade de Educação Fisica e Fisioterapia	Hospital de Clínicas da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9gdssk9	<NULL>	Patients with a confirmed diagnosis of cystic fibrosis; age between 12 and 34 years; with a Shwachman Kulczycki (SK) severity score greater than 7 (less severe disease); who agree to participate in the research; that have pulse oximeter monitoring available and internet access via cell phone or computer	Patients with significant cognitive and or orthopedic alterations; comorbidities that limit physical activity; pregnant women; patients who did not perform the exercise protocol for more than one week; those who for some reason do not keep in touch via cell phone or computer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-4fdmhm	Distúrbios mentais maternos na gestação e no pós-parto: detecção  e tratamento que refletem na relação familiar	Recruitment completed	Intervention	2019-10-08	<NULL>	<NULL>	3049	Maternal neuropsychiatric disorders in the pregnancy-puerperal cycle: detection and early intervention and its consequences in the family triad	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Católica de Pelotas	Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-4fdmhm	<NULL>	Pregnant women with depression; Pregnant Women at Risk for Depression	High Suicide Risk; Substance dependence; Performing prior psychotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-9xt9t5r	Do Abdominal Exercises help close muscle separations after childbirth?	Not yet recruiting	Intervention	2025-08-29	<NULL>	<NULL>	8241	Can Core Training reduce the inter-rectic distance in postpartum women with diastasis? randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9xt9t5r	<NULL>	The study will include women over 18 years of age with diastasis recti abdominis. Those with a distance of 2.8 cm between the muscle bellies at rest or 2.5 cm during flexion will be considered eligible. Furthermore, all volunteers with visible abdominal bulging on ultrasound will be included, regardless of the inter-rectus distance. Participants must be between 6 and 24 months postpartum, have no history of abdominal plastic surgery or umbilical hernia repair, have no abdominal wall hernia, have no low back pain, and are not pregnant. They must also not participate in other resistance exercise programs	Participants who, during training, become pregnant or develop any clinical condition that poses a health risk and compromises continued participation in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-2zbpvx3	Do combined non-invasive stimulation techniques affect the brain behavior of individuals with depressive symptoms? A randomized controlled trial	Recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8617	Does combined non-invasive neuromodulation affect cortical metrics in individuals with depressive symptoms? a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-11	Universidade Federal De Juíz De Fora - UFJF/GV	<NULL>	<NULL>	<NULL>	Participants with mild to moderate depressive disorder, aged between 18 and 45 years, duly diagnosed and identified through self-report.	Individuals with epilepsy, using anticonvulsant medication and/or with sleep deprivation; participants with metallic materials implanted in or near the head (examples, cochlear implant, implanted electrodes/stimulators, aneurysm clips or coils, firearm projectile fragments, jewelry and hair clips); participants with pacemakers or cardiac stents or other active devices where interaction with the electric field may interfere with their functioning; participants with eczema on the head.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-8wdrwhs	Do the characteristics of the Bite-Stabilizing Plate change depending on how it is printed?	Not yet recruiting	Intervention	2023-06-23	<NULL>	<NULL>	6174	Prosthetic properties of the Interocclusal Stabilizing Device, do they change according to the impression angle? A randomized crossover blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Uberlândia - Faculdade de Odontologia	Universidade Federal de Uberlândia - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-8wdrwhs	<NULL>	Patients with a probable diagnosis of Sleep Bruxism (SB); with discomfort in the masticatory muscles; apparent hypertrophy of the masseter; history of teeth grinding during the night; healthy oral mucosa, absence of systemic diseases; the autonomy of behavior and expression; both genders; over 18 years old	Patients diagnosed with moderate and severe Obstructive Sleep Apnea; absence of one or more molars; patients with upper removable dental prostheses; patients undergoing orthodontic treatment; patients with neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-2nmwxwt	Does a new mechanical ventilation strategy in the immediate postoperative period of cardiac surgery reduce pulmonary complications and is it capable of optimizing the functional capacity of patients at hospital discharge?	Recruitment completed	Intervention	2021-11-05	<NULL>	<NULL>	6846	Alveolar recruitment with peep titling in the immediate post-operative of cardiac surgery reduces pulmonary complications and is it able to optimize the functional capacity of patients in hospital discharge? A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-30	Hospital Universitário Pedro Ernesto (HUPE)	Hospital Universitário Pedro Ernesto (HUPE)	https://ensaiosclinicos.gov.br/rg/RBR-2nmwxwt	<NULL>	Patients aged 18 years or over, undergoing elective cardiac surgery for valve replacement (VT) or myocardial revascularization (MVR) or VT with CABG; surgery in the ascending Aortic Artery associated with cardiac surgery; correction of atrial septal defect (ASD); correction of interventricular communication (IVC) with programmed use of cardioplumonary bypass (CPB), clamping of the aorta artery, use of cardioplegia and conventional median sternotomy or median ministernotomy, volume adjusted to an inferior vena cava (IVC) measurement above 18 mm and mean arterial pressure ( MAP) greater than 80 mmHg.	Patients who refuse to participate in the study will be excluded; patients with previous cardiac surgery; pulmonary fibrosis; pulmonary emphysema; pneumonia diagnosed in the last 30 days; patients with pulmonary artery hypertension, with pulmonary artery systolic pressure greater than 45 mmHg; need for orotracheal intubation before arrival in the operating room; obese with body mass index (BMI) greater than 40 kg/m2; need for noradrenaline greater than 2 μg/kg/min; need for re-operation; pneumothorax and/or bubbling drains; patients with neuromuscular disease; myocardial revascularization surgery (CRVM) using a right internal mammary artery (MID) and radial artery graft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-3h5hffm	Does caffeine improve bodybuilding performance?	Recruiting	Intervention	2022-04-05	<NULL>	<NULL>	5329	Caffeine supplementation: ergogenic resource or placebo effect?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-15	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-3h5hffm	<NULL>	Being 35 and 50 years old. Being bodybuilders for at least 1 year; healthy; male; non-users of nutritional supplements; non-users of drugs (licit or illicit); not having suffered musculoskeletal injuries in the last 3 months	Having irregular frequency of training; bone deformities; not understanding the instructions related to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-42xvqrz	Does Combined Non-Invasive Neuromodulation affect cerebral oxygenation and the sympathetic/parasympathetic system in subjects with Depression? Controlled and randomized study	Not yet recruiting	Intervention	2024-06-12	<NULL>	<NULL>	7063	Does Combined Non-Invasive Neuromodulation affect intracranial hemodynamics and sympathetic/parasympathetic neurovegetative tone in subjects with Depressive Disorder? Controlled and randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-30	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-42xvqrz	<NULL>	Participants with mild and moderate depressive disorder; aged between 18 and 45 years; diagnosed and reported by a professional psychiatrist and/or psychologist	Individuals with epilepsy using anticonvulsant medication and/or sleep deprivation; participants with metallic materials implanted in or near the head; participants with cardiac pacemakers or wires (Stents) or with another active device in which the interaction with the electric field may interfere with its functioning; participants with eczema on the head	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-5h3sttg	Does daily consumption of two propolis capsules for three months improve the health conditions of obese women?	Recruiting	Intervention	2023-10-18	<NULL>	<NULL>	6515	Effects of supplementation with red propolis on the metabolic profile and body composition of obese women: a double blind randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal de Alagoas	Hospital Universiário Professor Alberto Antunes	https://ensaiosclinicos.gov.br/rg/RBR-5h3sttg	<NULL>	Women; between 19 and 40 years of age; obese (Body Mass Index greater than 35 kg/m^2); enrolled in the Bariatric Surgery Program at the Prof. Alberto Antunes University Hospital, Maceió, Alagoas	Being pregnant or lactating; making use of psychotropic drugs; having undergone recent surgery (last 6 months); being allergic to bee products and; living in a municipality outside the metropolitan region of Maceió (due to the difficulty of moving to the research location)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-6jg23g	Does desflurane anesthesia associated or not with nitrous oxide induce genotoxicity and oxidative stress in patients?	Recruitment completed	Intervention	2015-04-14	<NULL>	<NULL>	1002	Does desflurane anesthesia associated or not with nitrous oxide induce genotoxicity and oxidative stress in patients?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-29	Departamento de Anestesiologia	Faculdade de Medicina - Unesp Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6jg23g	<NULL>	Healthy individuals who do not present other disease unless the operative condition, undergoing elective ENT and ophthalmic surgery, lasting at least 90 minutes	Smoking, using illicit drugs and alcohol, users of daily vitamin supplements and / or antipyretics, analgesics, antibiotics, anti-inflammatory, among others, the occupationally exposed to paints, fuel, pesticides and hospital environments, those who received radiation ionizing or MRI done in less than 30 days, those who have already undergone chemotherapy or radiotherapy, patients with diseases such as asthma, hypertension, diabetes, cancer, infectious or inflammatory processes, and those who are not referred for surgery of ENT and ophthalmology clinic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-688jqz	Does Doxazosin treatment reduce the nightmares of Post Traumatic Stress Disorder?	Recruiting	Intervention	2020-10-15	<NULL>	<NULL>	4341	Impact of Doxazosin in the treatment of nightmares associated with Posttraumatic Stress Disorder: a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-12-04	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-688jqz	<NULL>	Age between 18 and 60 years (adults); Clinical diagnosis of PTSD by DSM 5 criteria; Using the first-line drug for the treatment of PTSD; Score equal to or greater than 2 (“moderately”), in item B2 (Recurrent distressing dreams) of the Brazilian version of the CAPS-5 scale (PTSD scale administered by the clinician).	Current or past diagnosis of Manic Episode, Hypomanic Episode or Psychotic Disorder (Schizophrenia, Schizoaffective, etc.); Current homicide risk (according to clinical evaluation); Current moderate to severe suicide risk (as assessed by the MINI instrument); Dependence Diagnosis \ Alcohol or Substance Abuse (except caffeine or nicotine) in the last 12 months using the MINI instrument; Diagnosis of acute or chronic clinical disease with risk of instability throughout the study (unstable angina, acute myocardial infarction in the last 6 months, congestive heart failure, chronic renal failure, liver failure, with Hepatitis B or Hepatitis C) .; Clinical diagnosis of severe neurological disease or dementia; Clinical diagnosis of Benign Paroxysmal Postural Vertigo and its differential diagnoses .; Clinical diagnosis of HIV \ AIDS symptomatic or in use of antiretroviral therapy; Pregnancy, lactation or refusal to initiate \ maintain effective contraceptive method .; Systolic Blood Pressure &lt;110 or Postural Hypotension; Initial electrocardiogram indicating clinically significant change in heart rate. ; Transaminases above twice the upper limit of normal; Current use of alpha-1 blockers (Terazosin, Prazosin) or history of inadequate outcome in treatment with this class of drugs for nightmares associated with PTSD; History of severe adverse reaction associated with the use of alpha-1 blockers (major allergic reaction, priapism, angioedema, ophthalmic disorder); Current use of alpha-2 agonists (clonidine, methyldopa, thiazine, guanfacine); Current use of conivaptan, boceprevir, idelalisib, oral antifungals, alfuzosin, pazopanib, silodosin, or tamulosin; Current use of benzodiazepines; Psychotherapy started in the two months prior to the beginning of the study; Refusal not to use Sildenafil, Tadalafil or Vardenafil during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-44bjjf	Does Ketamine in anesthesia produces superior, inferior or similar analgesia compared to Morphine in uterus removal surgery	Data analysis completed	Intervention	2019-09-09	<NULL>	<NULL>	2930	Does intrathecal Ketamine produces superior, inferior or similar analgesia compared to Morphine in Abdominal Hysterectomy surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-08	Hospital São José do Avaí	Santa Casa de Belo Horizonte - Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-44bjjf	<NULL>	The study enrolled women; over 18 years old; scheduled for elective abdominal hysterectomy at Hospital São José do Avaí; ASA I-III patients.	patients unlikely to be fully cooperative during the study; allergy to dipyrone/ketoprofen; non-indication for spinal anesthesia; cognitive impairment; severe renal impairment; lack of consent to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-63nqk4	Does massage increase mobility in muscles with rigidity?	Recruitment completed	Intervention	2018-10-22	<NULL>	<NULL>	2294	Does the connective tissue release increase range of motion in muscles with plastic hypertonia?	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-63nqk4	<NULL>	Elderly between 60 and 90 years old, of both genders, with Parkinson&apos;s disease and elderly between 60 and 90 years old, of both genders, neurologically healthy. Elderly patients with Parkinson&apos;s disease should present minimum muscular rigidity 1 in item 22 of the UPDRS III (motor).	Participants will be excluded if they present musculoskeletal conditions that contraindicate deep neck massage, such as a history of cervical trauma, disc herniation, cervical protrusion or skin continuity solution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-48qqsq2	Does Mental Fatigue caused by the use of social networks impair visual-motor skills of beach volleyball players? A randomized crossover study	Not yet recruiting	Intervention	2025-02-05	<NULL>	<NULL>	8225	Does Mental Fatigue caused by the use of social networks impair percepto-cognitive abilities of beach volleyball athletes? A randomized crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-10	Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba - CCS/UFPB	https://ensaiosclinicos.gov.br/rg/RBR-48qqsq2	<NULL>	Have been training beach volleyball for at least one year; have experience in official competitions; be training regularly for competitions; have not been diagnosed with neurological diseases; be between 15 and 21 years old; be male or female	Withdraw from participating for any reason; and/or suffer any type of injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-7gbffqc	Does nurse counseling reduce anxiety in women starting assisted reproductive treatments?	Not yet recruiting	Intervention	2023-08-09	<NULL>	<NULL>	6320	Nursing consultation to reduce anxiety in women starting assisted reproductive technology treatments: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7gbffqc	<NULL>	Infertility; IVF/ICSI	Intrauterine insemination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-47ngbg3	Does Pain after Root Canal Treatment depend on the number of appointments?	Recruitment completed	Intervention	2022-12-27	<NULL>	<NULL>	5781	Incidence of Postoperative Pain in single and multiple session Endodontic Treatments: clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Centro de Pesquisa da Universidade Positivo	Centro de Pesquisa da Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-47ngbg3	<NULL>	Both genders; older than 18 years; diagnosed with necrotic pulp; with normal physical and psychological health conditions; no use of analgesics and anti-inflammatories	Under 18 years old; vital pulp diagnosis; teeth with incomplete apex; pregnant; patients with non-odontogenic facial pain or chronic pain; patients who are taking analgesics and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-98x6b5	Does the &quot;mediterranization&quot; of a Brazilian meal induce cardiovascular and metabolic benefits?	Data analysis completed	Intervention	2015-09-20	<NULL>	<NULL>	620	Does the &quot;mediterranization&quot; of a Brazilian meal induce cardiometabolic benefits?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-15	Faculdade de Saúde Pública, Universidade de São Paulo	Faculdade de Saúde Pública, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-98x6b5	<NULL>	"Both sexes, aged between 35 and 69 years
Body mass index  between 25 and 40 kg / m2 with at least one of the following criteria: triglycerides above 150 mg/dl; total cholesterol above 230 mg/dL or LDL-C above 100 mg/dl or plasma fasting glucose between 100 and 124 mg/dl."	live outside the city of São Paulo; pregnant women; patients with neurological problems or severe psychiatric diseases;  use of anti-obesity medication; individuals with cancer, communicable and rheumatic diseases, liver or kidney failure, thyroid dysfunction untreated; a change of more than 5% of body weight within the last six months;  performing some type of diet or modifications to the usual eating pattern.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-8bwz7r	Does the enamel surrounding carious lesions influence the success of adhesive restorations in primary molars?	Recruiting	Intervention	2017-03-06	<NULL>	<NULL>	1178	Does the use of rotary instruments in the cavo-superficial enamel influences the survival of composite resin restorations in primary teeth submitted to selective removal of carious tissue?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-07	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-8bwz7r	<NULL>	Children from 5 to 9 years old; Primary molas - ICDAS 5; Without restoration or other lesions that interfere with the lesion to be treated	Children with difficult behavior; Tooth without antagonist; Lesions involving more than one surface; Painful symptomatology; Signs of pulpal alteration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-94r9wx	Does the high level of physical activity protect the human body against the negative effects of sleep deprivation?	Recruiting	Intervention	2018-09-26	<NULL>	<NULL>	2238	Sleep deprivation responses on cardiovascular measures in young people with different levels of physical activity submitted to a high-intensity interval exercise session	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-18	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-94r9wx	<NULL>	Low or high level of physical activity; without sleep disorders; habitual sleep of 7 to 8 hours per night; free from chronic degenerative diseases; no change in electrocardiogram at rest or during exercise; not using cardiovascular or psychotropic or vasoactive medications; present body mass index 30 kg per m2	No smoking or ex-smoker; do not consume more than 2 servings per day of alcohol; do not take coffee-type sympathomimetics or stimulants or alcohol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-8f4s9d	Does the laser in combination with exercises improve pain and function of patients with knee osteoarthritis?	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	3187	Does the low-level laser therapy in combination with therapeutic exercises improve pain and function of patients with knee osteoarthritis? A randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-30	Universidade Federal de São Carlos	Departamento de Fisioterapia (DFisio) da UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-8f4s9d	<NULL>	Present OA diagnosis at least in one knee compartment (tibiofemoral and/or patellofemoral); present grade 2 or 3 in the radiographic examination of OA; present a minimum pain intensity of 4 cm in the visual analogue scale (total of 10 cm) at the most affected knee	Body mass index (BMI) greater than or equal to 35 kg/m2; physical therapy in the 3 months prior to recruitment; intra-articular therapy with steroid anti-inflammatory drugs in the knees 6 months prior to recruitment; ankle, knee or hip surgery of both limbs; and present any medical condition that could affect the participation in the study (cardiorespiratory, neurological and/or musculoskeletal diseases)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-8hcg2c	Does the method of tooth isolation influence the longevity of restorations?	Data analysis completed	Intervention	2020-01-06	<NULL>	<NULL>	5698	Does ruber dam isolation increases the longevity of restorations of primary molars? A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8hcg2c	<NULL>	Patients aged 3 to 9 years old who have at least one class I or II caries lesion in deciduous molars; 198 teeth; who radiographically have at least two thirds root, and lesions D1 and D2, where restorative treatment is indicated. E1 Radiolucidity in the outer half of enamel; E2 Radiolucidity in the inner half of enamel; D1 Radiolucidity in the external third of dentin; D2 Radiolucidity in the middle third of dentin; D3 Radiolucidity in the internal third of dentin.	spontaneous pain; fistula; mobility not compatible with the period of root resorption; advanced rhizolysis more than 2/3 of root resorption; participants who were included in the course were not included in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-6vnftw	Does the physiotherapy maneuver improve diaphragm mobility and blood oxygenation in premature newborns?	Recruitment completed	Intervention	2020-10-29	<NULL>	<NULL>	5432	Impact of manual costal stabilization on diaphragmatic excursion, fraction of diaphragmatic shortening and peripheral oxygen saturation in premature newborns	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-10	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6vnftw	<NULL>	Newborn with gestational age less than or equal to 37 weeks, admitted to the NICU; Between the third and tenth days of life; Informed Consent Form signed by the person responsible.	Newborns with malformations of the central nervous system, chest and heart disease; Newborns with contraindications to respiratory physiotherapy such as: presence of pulmonary hemorrhage, diaphragmatic hernia, severe pulmonary hypertension, undrained pneumothorax, thrombocytopenia, omphalocele or gastroschisis not yet corrected; Newborns with contraindications to the use of the study technique such as: chest drain, immediate postoperative abdominal or thoracic surgery, Silvermann Andersen Bulletin greater than three.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-4kcd92s	Does the positioning and design of attachments affect tooth movement in the in-house aligner system? A randomized clinical trial	Recruitment completed	Intervention	2024-06-17	<NULL>	<NULL>	7071	Biomechanic aspects of orthodontic attachments in in-house aligners: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-16	Pontifícia Universidade Católica de Minas Gerais - PUCMG	Pontifícia Universidade Católica de Minas Gerais - PUCMG	https://ensaiosclinicos.gov.br/rg/RBR-4kcd92s	<NULL>	Previous preventive orthodontic treatment carried out at PUC Minas and the need for the corrective orthodontic phase to complete the case; need for corrective orthodontic treatment with mild to moderate discrepancies; permanent denture completely erupted, with the permanent second molars being in the mouth or not; absence of systemic diseases or regular use of medications that could interfere with average growth and orthodontic movement; both genders	Patients who do not have permanent dentures; who have severe malocclusion; who have systemic diseases that may influence orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-38v67k	Does the protocol  exercises specific can change the movements of the shoulder?	Recruitment completed	Intervention	2016-06-29	<NULL>	<NULL>	903	Does the training of motor control and muscle strengthening could change the scapulotoracic joint kinematic?	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-38v67k	<NULL>	Diagnosis of impingement syndrome; scapular dyskinesis present type I or II; aged between 18 and 40 years; history of shoulder pain lasting more than a week; active range of motion the arm 120 degrees.	History of trauma; shoulder surgery; deformity in the thoracic spine; instability; complete rupture of the tendons of the shoulder; pulmonary and heart diseases; neurological diseases; index greater than 28kg / m 2 body weight; reproduction of shoulder pain with radiating pain, numbness or tingling in the arm; systemic disease; perform physical therapy later	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-8tsrb7	Does the videogame training increases the power of the female pelvic floor muscles?	Recruitment completed	Intervention	2014-04-02	<NULL>	<NULL>	282	Does the Virtual Rehabilitation Training increases contractility of the female pelvic floor muscles?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-15	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8tsrb7	<NULL>	Women aged from 40 years.	Presence of urinary tract infection; having performed previously, pelvic floor muscles training supervised by a professional health; Carriers myopathies and diseases with known alteration of collagen; Carriers neurological abnormalities, cognitive disorders and physical limitations that preclude participation in the study; presence of dystopia of grade III or IV found by physical examination by Pelvic Organ Prolapse Quantification System - POP-Q.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-8td9hs	Donepezil´s effects in patientes with long standing Tinnitus	Not yet recruiting	Intervention	2020-11-03	<NULL>	<NULL>	4360	Efficacy of Donepezil in patients with chronic Tinnitus	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2021-01-29	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8td9hs	<NULL>	Adults over 18 years old; with tinnitus one-sided or bilateral, for more than 6 months, caused by sensorineural hearing loss	Pregnant women, nursing mothers;known hypersensitivity to donepezil or piperidine derivatives; with external and or middle ear pathologies; other tympanograms than type A; with mixed or conductive hearing loss; using medications similar to donepezil (memantine, rivastigmine, galantamine) or less than 30 days of use; patients with supraventricular abnormalities of cardiac conduction or bradycardia, seizure, schizophrenia, ulcer, asthma or severe COPD; patients using carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampicin, ketoconazole and quinidine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-64vbk2	Dorsal musculature activity in undergraduate teachers	Data analysis completed	Intervention	2018-10-19	<NULL>	<NULL>	2291	Electrical activity of the paraespinal muscles in the flexion and extension of the column in teachers of the dynamic faculty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-20	Faculdade Dinâmica do Vale do Piranga	Faculdade Dinâmica do Vale do Piranga	https://ensaiosclinicos.gov.br/rg/RBR-64vbk2	<NULL>	Be part of the staff of the Dynamic College of Piranga Valley and sign the Term of Consent Free and Clarified	Severe postural deviations; acute musculoskeletal dysfunctions; neurological changes; pregnancy; trauma to the lower back and menopause.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-8648fg	Dose-response effect of strength training on the rehabilitation of patients with Patellofemoral Pain Syndrome	Not yet recruiting	Intervention	2020-05-18	<NULL>	<NULL>	3839	Dose-response effect of strength training on the rehabilitation of patients with patellofemoral pain syndrome: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Nathalia Trevisol de Oliveira	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8648fg	<NULL>	Female individuals aged between 18 and 40 years, able to carry out the training and proposed evaluations and who are willing to participate in the study on a voluntary basis after the disclosure of the work on social networks on the internet. The syndrome will be diagnosed by a physiotherapy professional with experience in managing this patient profile, based on the criteria of the American Phisycal Therapy Association guidelines consensus: presence of retropatellar or peripatellar pain; pain reproduction during the squat; performance of other functional activities such as sustained knee flexion, going up or down stairs, kneeling, running.	Presence of musculoskeletal injuries in the lower limbs that prevent or impair the performance of exercises and assessment; history of physical trauma involving the knees or lower limbs, such as traffic accidents, falls, bruises, in the last twelve months; body mass index (BMI)&gt; 30; having performed a rehabilitation protocol for patellofemoral pain syndrome up to six months before data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-10yqwrk6	Double blind randomized clinical trial of &quot;Espinheira Santa&quot; as a strategy of management of dyspepsia in gastroesophageal reflux disease	Not yet recruiting	Intervention	2021-03-26	<NULL>	<NULL>	4581	Double-blind randomized clinical trial of Maytenus ilicifolia as a strategy to manage dyspepsia in gastroesophageal reflux disease	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-10yqwrk6	<NULL>	Voluntary patients, of both sexes, aged between 18 and 60 years who are looking for medical attention in Health Units and who, after medical evaluation, present symptoms of dyspepsia, at least two of these symptoms, regurgitation, taste of sour or bitter fluid in the mouth, and/or epigastric pain and/or burning pain (ascending or not) in the week before the consultation, of gastroesophageal reflux disease. Patients able to be treated without endoscopic investigation and without evidence of disease or use of medication that justifies the symptoms will be included.	Patients who are referred for an endoscopic examination and who are intolerant to the treatment compounds will be excluded from the medical evaluation. Pregnant women or women of reproductive age who do not use hormonal contraceptives will be excluded. Patients with a history of glaucoma, paralytic ileum, stenosis or mechanical obstruction of the gastrointestinal tract, megacolon, patients with acute-angle glaucoma, urinary retention or prostate hyperplasia will be excluded patients using any drugs with antiulcer or prokinetic properties in the week prior to recruitment that present structural changes related to reflux and dyspepsia, such as hiatus hernia and esophageal atresia, hepatopathies and patients using drugs that make pharmacological interaction with compounds of Maytenus ilicifolia dry extract.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-3s85fz4	Double conjunctival flap with suture versus conjunctival autograft with glue for primary pterygium: a prospective, randomized study	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8496	Conjunctival autotransplantation with glue versus double flap with suture for primary pterygium. Interventional study	<NULL>	2, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-20	Hospital Universitário da Universidade Federal do Maranhão/HU/UFMA	<NULL>	<NULL>	<NULL>	The inclusion criteria will be patients aged over 18 and under 80 years; without the occurrence of ocular surface disease, including dry eye and blepharitis, and with availability for clinical follow-up for at least six months after surgery. This information will be collected during ophthalmological consultations. To eliminate duplication bias when using both eyes from the same patient, only the first operated eye will be included in the analysis.	Exclusion criteria will include patients under 18 or over 80 years of age; presence of symblepharon; cicatricial conjunctival diseases; glaucoma; ocular allergy; recurrent pterygium in the ipsilateral eye, and those who do not sign the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:13
RBR-7k576j	Double treatment with Glycopyrronium and Indacaterol versus single treatment with Glycopyrronium in treatment of lung disease	Not yet recruiting	Intervention	2018-10-04	<NULL>	<NULL>	2262	Dual therapy with Glycopyrronium and Indacaterol versus monotherapy with Glycopyrronium in treatment of Copd patients	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-10-12	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7k576j	<NULL>	Patients (men and women) with COPD confirmed by spirometry. The diagnosis of the disease will be made by performing spirometry that will confirm the obstruction to the airflow through the result of the relation between forced expiratory volume in the first second (FEV1) and forced vital capacity of less than seventy per cent after use of inhaled bronchodilator. The patient must have stable disease. No need for hospitalization in the thirty days prior to the evaluation. Preserved neurocognitive functions. Be an adult and agree to participate in the study.	Patients with respiratory tract infection or who have been hospitalized for an exacerbation in the last month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-7jkmhf5	Doxi-Rio: study on the use of Doxycycline to prevent sexually transmitted infections in Rio de Janeiro	Not yet recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8442	Doxi-Rio: pilot implementation of post-exposure prophylaxis for sexually transmitted infections with Doxycycline in Rio de Janeiro, Brazil	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Instituto Nacional de Infectologia Evandro Chagas	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-7jkmhf5	<NULL>	Men (cis or trans) who have sex with men, transvestites or trans women; diagnosed with HIV infection or current use of PrEP for at least 6 months; age 18 years or older; laboratory diagnosis or self-reported diagnosis of at least one bacterial sexually transmitted infection (Chlamydia, Gonorrhea or Syphilis) in the last 12 months; consent to participate in the study after receiving adequate information about the study	Allergy to antibiotics of the Tetracycline class; current medications that may impact the metabolism of Doxycycline or that are contraindicated with Doxycycline (Systemic Retinoids, Barbiturates, Carbamazepine and Phenytoin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-9j7qqr	Dressing with product derived from snake venom to treat wounds in the legs	Not yet recruiting	Intervention	2015-06-29	<NULL>	<NULL>	4439	Fibrin sealant derived from snake venom for the treatment of venous ulcers: non controlled phase I / II to evaluate the safety, efficacy and confirm the lowest dose clinical trial - study selante II	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Medicina de Botucatu - Unesp	Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-9j7qqr	<NULL>	Sign the term of free and informed consent; patients 18 years of age or older, of both sexes; chronic venous disease with chronic venous ulcers evidenced by one or more of the following signs: hyperpigmentation of the distal third of the lower limb, stasis eczema,  lipodermatosclerosis, varicose veins; to have at least one ulcer whose time evolution is minimum of 6 weeks and a maximum of 5 years; display the sum of the areas of the ulcers of both members between 5 and 60 square centimeters; at least one ulcer whose major area is above 5 square centimeters; do not use the following drugs in the last two weeks prior to screening: venotonics,  pentoxifylline, fibrinolytic drugs; Available to attend once a week for treatment.	"Leg ulcers of other etiologies ( causes hematological , neoplastic , infectious , among others) ; use of anticoagulants ; infected ulcers , or associated with erysipelas , cellulitis or lymphangitis; ulcer with critical colonization , ie ,large amount of exudate and / or foul and / or yellowish staining of the wound bed and / or green and / or red opaque odor and / or friable granulation tissue ; necrosis in the ulcer bed ; devitalized background with ulcer covering all your bed; venous ulcers associated with peripheral arterial disease that is characterized when the systolic ankle-brachial index is less than 0.9 and / or absence of distal pulses; being unable or does not wish to remain with compressive treatment of lower limb for seven days; to have a history of allergy to treatment with Unna boot; to have a history of allergy to treatment with essential fatty acid; known or suspected pregnancy;
values coagulation outside the normal range ( Activated partial thromboplastin time more than 1.25 and time and prothrombin activity less than 70% or more than 100%); women of childbearing potential not using contraception."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:12
RBR-7hfwzj	Dressings, nutritional supplementation and teaching of the patient and caregiver for the healing of bedsores	Not yet recruiting	Intervention	2018-07-19	<NULL>	<NULL>	2029	Effect of combined technology in the treatment of pressure injuries: contribution for clinic care management	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Goiás	Centro Estadual de Reabilitação e Readaptação Dr Henrique Santillo	https://ensaiosclinicos.gov.br/rg/RBR-7hfwzj	<NULL>	"Patients 18 years of age or over; pressure injury in stages 2, 3 or 4 up until 24 cm2; body mass index equal or greater than 18,5 kg/m2 and lower than 30 kg/m2 and therapeutic plan of hospitalization in the institution for at least 30 days; scoring on the mini-test of mental state equal or greater the expected scoring for the scholarity

Caregivers 18 years of age or older; scoring on the mini-test of mental state equal or greater the expected scoring for the scholarity"	"Patients with a previous history of allergy to any plant from the Asteraceae or Pedaliaceae family; renal or liver diseases; osteomyelitis; cellulitis; systemic use of corticoids; immunosuppressants, radiation, chemotherapy less than four weeks before entering this study and myiasis

Caregivers with visual deficit that blocks visualization of the educational material for the care; hearing deficiency moderate to severe that blocks orientation comprehension"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7p43fkc	Drug delivery systems through eye drops for the treatment of Dry Eye symptoms	Recruiting	Intervention	2023-10-16	<NULL>	<NULL>	6510	Drug delivery systems for treating Diseases of the Anterior Segment of the Eye	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2023-03-31	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7p43fkc	<NULL>	The authors intend to include 60 participants, divided into three groups of 20 (Experimental Group I: insulin eye drops; Experimental Group II: cannabidiol eye drops; Placebo Group: eye drops without active ingredient). Subjects must meet all inclusion criteria to be eligible to participate in the study: subjects of any color and gender, over 18 years of age at the time of enrollment; read, understand, and sign the informed consent form; understand the study procedures and adhere to them throughout the study; have a history of dry eye, and have used tear-lubricating agents within the last 4 months; basal tear &lt;5 mm; Corneal coloration 2 (NEI grading system, Lemp 1995) in at least one eye	Subjects who meet any of the exclusion criteria at visit 1 will be excluded from participation in the study: subjects who have any active infectious ocular conditions; individuals with inflammatory eye diseases (eg, conjunctivitis, keratitis, uveitis, or others) unrelated to dry eye; continued use of topical eye medications (including ocular cyclosporine and glaucoma medications) with the exception of artificial tears or lubricating ointments; taking medications that can cause dry eyes immediately prior to this study (Wong, Lan et al. 2011); any physical or mental disability that impedes participation and the ability to give informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-3j3cktx	Drug treatment of Diabetes in pregnancy	Recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6431	Metformin versus insulin in the glycemic control in pregnancy	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2023-08-12	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-3j3cktx	<NULL>	Pregnant women diagnosed with diabetes type two or gestational diabetes; pregnant women that require medication for glycemic control; pregnant women that agree to participate of the study; pregnant women over 18 years old; pregnant women following in the prenatal care unit of our service	Pregnant women diagnosed with diabetes that do not require medication for glycemic control, pregnant women that cannot use any of the medication (insulin or metformin); pregnant women that refuse to participate of the study; pregnant women under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-8462fhs	Dry Needling and temporomandibular dysfunction	Data analysis completed	Intervention	2024-01-14	<NULL>	<NULL>	6726	Evaluation of the effects of Dry Needling and Manual Therapy on pain in patients with Temporomandibular Disorder and its relationship with fear of Covid-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-04	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-8462fhs	<NULL>	Adults between 18 and 40 years old; both genders; diagnosed with Temporomandibular Disorders (TMD)	People under 18 and over 40; people undergoing orofacial treatment; people using psychotropic medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-74srwz	Dual-layer stent versus close cell-stents: a carotid angioplasty stenting randomized trial	Recruitment completed	Intervention	2019-10-23	<NULL>	<NULL>	3123	Randomized double-blind clinical trial of carotid angioplasty with distal cerebral protection filter comparing closed-cell stent with double-layer stent	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Hospital de Clínicas de Ribeirão Preto - Universidade de São Paulo	Hospital da Cidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-74srwz	<NULL>	Patient over 18 years of age; Life expectancy greater than 1 year; Internal carotid artery stenosis&gt; or = 70% associated with ipsilateral symptoms such as TIA, stroke or retinal ischemia; Internal carotid artery stenosis&gt; or = 70% asymptomatic	"Contraindication for antiplatelet therapy;
Contraindication for use of iodinated contrast media;
Patients with stroke or TIA classified by A-S-C-O as C1 or O1, that is, they present mitral stenosis; prosthetic heart valve; AMI in the previous 4 weeks; mural thrombus in the left chambers; left ventricular aneurysm;
documented history of chronic or transient AF or flutter with or without &quot;spontaneous echo contrast&quot;; thrombus in the left atrium; sinus node disease syndrome; dilated cardiomyopathy; FE &lt;35%; endocarditis; intracardiac mass; patent foramen ovale plus thrombosis in situ; FOP plus concomitant pulmonary embolism or DVT and preceding cerebral infarction; dolicectasis complicated with aneurysm; polycythemia vera, thrombocytosis&gt; 800,000; LES; criteria for SAAF; Fabry disease; sickle cell anemia; ruptured cerebral aneurysm, with or without demonstration of spasm in the cerebral infarct territory; homozygous for hyperhomocystinuria; acute arterial dissection."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-3jj783t	Durability of composite resin restorations in root canal treated teeth associated with an adjustable root canal post, fiberglass post or no post: randomized clinical trial	Recruiting	Intervention	2024-01-05	<NULL>	<NULL>	6705	Longevity of composite resin restorations in endodontically treated teeth associated with an adjustable post to the root canal, fiberglass post or without an intraradicular retainer: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-05	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3jj783t	<NULL>	Participants aged between 18 and 65 years old; both genders; with adequate oral health; who had endodontically treated teeth with 50% or less of coronal remaining	Patients who had teeth with root involvement such as fractures or cracks; mobility; poor oral hygiene; chronic or aggressive periodontitis; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-45vq9cb	Durability of toothbrushes in orthodontic patients: a randomized clinical trial	Not yet recruiting	Intervention	2024-01-10	<NULL>	<NULL>	6717	Durability and efficiency of orthodontic toothbrushes in patients with fixed appliances: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-45vq9cb	<NULL>	Patients in the permanent dentition phase; between 13 and 50 years old; with upper and lower fixed braces; bonded or banded from molar to molar; of both sexes; in good health and with a minimum of 20 permanent teeth, excluding third molars	Patients with active caries; patients with dental development defects; pregnant women; patients with systemic diseases (diabetics or smokers); patients using medications that may affect gingival health (such as calcium channel blockers; cyclosporine and anticoagulants) will be previously excluded; individuals allergic to the plaque discloser and who have limited manual dexterity and cognitive difficulties; cleft lip and palate; syndromes and/or craniofacial anomalies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-9vmkcb	Duration of analgesia of the perineum with ice packs after childbirth	Recruitment completed	Intervention	2015-02-26	<NULL>	<NULL>	406	Duration of the analgesic effect of cryotherapy on perineal pain after childbirth: clinical trial	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-12-11	Universidade de São Paulo	Amparo Maternal	https://ensaiosclinicos.gov.br/rg/RBR-9vmkcb	<NULL>	"equal to or greater than 18 years old; 
at least one vaginal delivery prior to the current; 
Current normal delivery; 
term pregnancy (between 37 and 41 weeks and 6 days gestational age); 
single live fetus and cephalic presentation; 
not have received the analgesic prior to study entry three hours; 
be within 6 to 24 h post-partum; 
not have received spinal and / or epidural anesthesia; 
refer largest perineal pain or equal to 3 on a scale at the time of study enrollment; 
have had RN in good clinical condition; 
not show clinical or obstetric complications; 
not present difficulties of communication or understanding of the English language."	Receiving analgesic or anti-inflammatory until 120 min after the use of cryotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-2hb4p8	Dynamic equilibrium of the lumbar and pelvis for the treatment of stress urinary incontinence in women	Recruitment completed	Intervention	2015-05-08	<NULL>	<NULL>	463	Dynamic stabilization lumbopelvic for treatment of urinary incontinence in womem	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Faculdade de Medicina - UFJF	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2hb4p8	<NULL>	literate women aged greater than or equal to 18 years with reports of efforts to urinary losses and sexually active	Possessing dystopias grades III and IV or use of anticholinergic drugs, pregnant women, women in treatment for urinary incontinence, pelvic diaphragm dysfunction or changes the alignment of the spine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-4byhxb6	Dynamic Registry TARGET Brazil  - single arm, prospective, multicenter and observational trial	Recruiting	Observational	2022-01-18	<NULL>	<NULL>	5150	Dynamic Registry TARGET Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-27	Microport Scientific Vascular Brasil LTDA	Microport Scientific Vascular Brasil LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4byhxb6	<NULL>	Volunteers over 18 years of age; percutaneous coronary intervention in less than 96 hours, performed according local interventional cardiology laboratory routine, with implantation or attempted implantation of one or more Firehawk stents for the treatment of symptomatic ischemic heart disease and/or with objective evidence of myocardial ischemia; patient will be informed of the nature of the study, agree to the follow up and provide written informed consent, approved by the local Ethics Committee.	Planned cardiac or non-cardiac surgery within 6 months of the index procedure; Patient with a life expectancy of less than 12 months; Any significant medical condition that in the investigator&apos;s opinion may interfere with optimal patient participation in this study; Participation in another survey in the last 12 months, unless that there may be direct benefit to the research subject; Percutaneous coronary intervention performed for the treatment of non-atherosclerotic coronary heart disease; Percutaneous coronary intervention performed for the treatment of previously implanted stent thrombosis; There are no restrictions regarding the number of lesions or stents treated, the treated arteries or the morphology of the lesions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-3kh3y2s	Dysbiosis in the oral cavity of patients undergoing invasive mechanical ventilation and receiving oral care, combined with antimicrobial photodynamic therapy.	Recruiting	Intervention	2023-07-30	<NULL>	<NULL>	6287	Dysbiosis in the oral cavity and its relationship with the complications of patients on invasive mechanical ventilation and under oral care, associated or not with antimicrobial photodynamic therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-15	Faculdade de Odontologia da Universidade de São Paulo	Associação Hospitalar Lenoir Vargas Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-3kh3y2s	<NULL>	Critically ill patients admitted to the Intensive Care Unit; undergoing mechanical ventilation; intubated within 24 hours; and aged 18 years or older; both genders	Pregnant patients; edentulous patients; patients with severe traumatic brain injury; postoperative patients expected to be discharged within the first 24 hours; patients diagnosed with COVID; patients intubated for more than 24 hours; patients for whom sample collection is not possible; and patients whose legal representative does not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-8zjf6b	E-BRAIN Project: Investigating the effect of different forms of physical exercises on the cognition of the elderly	Recruitment completed	Intervention	2017-12-20	<NULL>	<NULL>	1532	Physical exercise, cognition and neuroplasticity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade de São Paulo - Escola de educação Física e esporte	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8zjf6b	<NULL>	"Present score in the mini-mental state exam (Mini Metal) greater than 23 points

They should not have performed any type of physical exercise intervention in the six months prior to the start of the present clinical trial;
Being literate and not having a higher education (between 3 and 12 years of schooling - elementary school to high school);
No motor impairment, musculoskeletal injury or comorbidities that prevent exercise;
Have no history of stroke or neological disease;
Have a medical certificate attested by the professional involved in the research, confirming the possibility of participating in the exercise progra"	"Do not agree to participate in the evaluations foreseen in the research;
Not available to participate in interventions that will occur on weekdays, in the afternoon or at night."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-2db2syn	Ear Acupuncture for Quitting Smoking and Stress Relief: a clinical study	Not yet recruiting	Intervention	2026-03-12	<NULL>	<NULL>	8971	Auricular Acupuncture for Smoking Reduction/Cessation and Emotional Disorders in smokers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de Viçosa	<NULL>	<NULL>	<NULL>	Individuals who consume at least one cigarette daily at the time of data collection; present preserved cognitive function; exhibit moderate to high levels of anxiety, stress, and/or depression (Depression, Anxiety, and Stress Scale — DASS-21) and fatigue (Fatigue Assessment Scale — FAS), or poor sleep quality (Pittsburgh Sleep Quality Index — PSQI); are residents of the municipalities or members of the university community in Viçosa; have time availability for evaluations and treatment sessions; agree to be randomly allocated to the study groups; of both genders; and are aged 18 years or older	Ear piercings, except in the earlobe; history of allergy to metal or microporous tape; history of photosensitivity; presence of lesions, inflammation, deformity, or tattoos on the ear; history of skin cancer in the head and neck region; use of hearing aids; use of chemical peels (retinoic acid, retinol, Vitanol-A, tretinoin, isotretinoin) and/or Roaccutane® (Isotretinoin) within six months prior to the start of treatment, due to their photosensitizing properties; immunocompromised individuals (e.g., undergoing cancer treatment or using immunosuppressants); epilepsy; use of a cardiac pacemaker; pregnant or lactating women, or those planning to become pregnant during the study period; rejection of or fear of receiving the technique; and undergoing any other concomitant energetic therapy during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-46st4w	Ear cavity closure with frozen bone for otitis revision surgery	Recruitment completed	Intervention	2016-01-06	<NULL>	<NULL>	675	Mastoid cavity obliteration with particulated fresh frozen bone in revision surgery for patients with chronic otitis media with cholesteatoma	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-07-10	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Anna Carolina de Oliveira Fonseca	https://ensaiosclinicos.gov.br/rg/RBR-46st4w	<NULL>	Adults, with clinical indication of mastoidectomy revision surgery due to chronic otitis media.	diabetes, bone metabolism diseases, smokers, coagulation disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-6r8y39d	Ear stimuli to reduce high blood pressure in adults and the elderly	Recruitment completed	Intervention	2023-08-18	<NULL>	<NULL>	6359	Auriculotherapy and its effect on pressure levels in adult and elderly hyperensive patitents	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal de Mato Grosso - Campus Cuiabá	Hospital Universitário Júlio Müller	https://ensaiosclinicos.gov.br/rg/RBR-6r8y39d	<NULL>	Medical diagnosis of systemic arterial hypertension; who agree to participate in the research; who are available to attend the application site to receive auriculotherapy	Presence of infection, inflammation or injury in the ear; presence of piercing in the ear (except normal earring); tape allergy; being pregnant, being in the puerperium and/or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-8b33r8	Early bedside sedestation after heart surgery: clinical and psychological repercussions.	Recruitment completed	Intervention	2016-04-25	<NULL>	<NULL>	812	early bedside sedestation in the postoperative cardiac surgery: clinical and psychological repercussions .	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-11	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8b33r8	<NULL>	patients older than 18 years undergoing cardiac surgery; sign the Informed Consent and Informed .	reoperation after surgery; those who come to peri -operative death; present need for invasive mechanical ventilation for longer than 24 hours; hospital stay above 10 days after surgery; are doing use of tranquilizers and antidepressants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-4tdvt9	Early exercise in patients with artificial breathing	Data analysis completed	Intervention	2015-10-13	<NULL>	<NULL>	629	Early mobilization of critical patients in mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-12	Hospital de Clínicas de Porto Alegre - HCPA	Hospital de Clínicas de Porto Alegre - HCPA	https://ensaiosclinicos.gov.br/rg/RBR-4tdvt9	<NULL>	Patients in invasive mechanical ventilation for 72 hours.	Neuromuscular disease; stroke; multiple sclerosis; amyotrophic lateral sclerosis; myasthenia gravis; Guillain Barré; extubated within 48 hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-9n35t4	Early Mobility Protocol to neurological inpatients	Data analysis completed	Intervention	2017-09-15	<NULL>	<NULL>	1375	Developing an Early Mobility Protocol to neurological patients in the wards of hucff	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho - HUCFF	https://ensaiosclinicos.gov.br/rg/RBR-9n35t4	<NULL>	systolic blood pressure between 90 and 160 mmHg, heart rate between 40 and 130 beats per minute (bpm), respiratory rate between 10 and 40 breaths per minute, peripheral oxygen saturation &gt;90%	Mecanical Ventilation in Controlled Mode; Need for Vasopressors; Recent Myocardial infarction; Acute Fracture in Lower Limbs; Fracture with instability of spine; Platelets &lt; 20 000; Hematocrit &lt; 25%; Hemoglobin &lt; 7 g/dL	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-5jhmkn6	Early mobilization in patients undergoing Bariatric Surgery	Recruiting	Intervention	2024-03-27	<NULL>	<NULL>	6899	Early mobilization in patients undergoing Laparoscopic Bariatric Surgery: interventional clinical study	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal de Alfenas	Hospital e Maternidade Galileo	https://ensaiosclinicos.gov.br/rg/RBR-5jhmkn6	<NULL>	Age greater than 18 years old up to 65 years old; both genders; patients who will undergo bariatric and metabolic surgery via laparoscopy; adequate preoperative pulmonary function test; patients without previous lung disease; patients without radiological changes preoperatively; those who agree to sign the Free and Informed Consent Form	Hemodynamic instability (MAP &lt; 60mmHg) in the postoperative period that prevents early ambulation; conversion from laparoscopy to laparotomy; patients who underwent a surgical procedure other than bariatric and metabolic surgery, such as cholecystectomy, herniorrhaphy, hiatoplasty and liver biopsy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-92j6qf	Early mobilization of patients hospitalized in the intensive care unit	Data analysis completed	Intervention	2018-04-11	<NULL>	<NULL>	1705	Early mobilization of critically ill patients - randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-92j6qf	<NULL>	Patients with at least 24 hours of admission to the Intensive Care Unit, with or without sedation; older than 18 years old; both genders; presenting significant hemodynamic stability considered as the absence of hypotension or vasopressóricas need for drugs at lower doses less than 1mcg/hora/kg noradrenaline; absence of neuromuscular, oncological, neurological diseases or traumotortopédicas including amputation) prior or recent surgeries; have normal functional ambulation, use of assistive device accepting gait; accepted to participate in the certificate states the responsibility for the patient when they had not been enough awareness for decision making.	Hospitalization prior period with less than thirty days prior to the date of admission to HRTN; Patients transferred from other hospitals to CTI CTI&apos;s HRTN; Patient aware that refused to participate in any of the two groups after randomization; Refusal of the patient to participate in this study after recovering state of consciousness suited to making decisions when your entry is made by authorization of family and / or guardian; Patients who require cardiopulmonary resuscitation during the ICU stay; Patients who had a change in diagnosis as stroke as a cause of ICU stay current.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-2dbzdy	Early Neuromuscular Electrical Stimulation in Critically Ill Trauma Patients	Data analysis completed	Intervention	2016-08-23	<NULL>	<NULL>	970	Neuromuscular electrical stimulation in patients with Traumatic Brain Injury under prolonged mechanical ventilation: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Universidade de Brasilia - Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	Hospital de Base do DF	https://ensaiosclinicos.gov.br/rg/RBR-2dbzdy	<NULL>	Major trauma patients were assessed for eligibility within the first 24 hours after hospital admission. Adults older than 18 years old with invasive mechanical ventilation were included.	pregnancy; stroke; previous neuromuscular disease; suspicion of brain death; lower limb amputation, fracture or skin lesion that restrained ultrasound evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-7nt59gn	Early Oral Refeeding for Cancer patients undergoing Bowel Surgery	Not yet recruiting	Intervention	2023-05-19	<NULL>	<NULL>	6097	Early oral refeeding in cancer patients undergoing colorectal surgery: a controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-15	Empresa Brasileira de Serviços Hospitalares	Hospital Universitário Professor Alberto Antunes	https://ensaiosclinicos.gov.br/rg/RBR-7nt59gn	<NULL>	Adults and seniors; both sexes; aged 30 years or older; with a proposal to perform elective colorectal surgery due to colorectal neoplasia	Patients with limited mobility; clinical and/or postoperative complications resulting from surgery performed before the start of this study; hospitalizations for diagnostic procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-25zhwfj	Early Palliative Care for patients with Hematological Neoplasms	Recruiting	Intervention	2023-09-05	<NULL>	<NULL>	6407	Prognostic and Epidemiological Evaluation of Palliative Care in Hematological Diseases	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-16	Hemocentro de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-25zhwfj	<NULL>	Multiple myeloma, newly diagnosed; previously untreated. Acute myeloid leukemia, newly diagnosed; ineligible to intensive chemotherapy; 60 years-old or higher	Cognitive impairment compromising responses to clinical questionaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8bgcs3	Early physical exercise in ischemic stroke patients undergoing thrombolytic treatment	Recruiting	Intervention	2020-07-31	<NULL>	<NULL>	4076	Very early mobilization after thrombolysis in a stroke unit in Salvador - Ba: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-05	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-8bgcs3	<NULL>	&gt; 18 years old, thrombolyzed, hemodynamically stable, oxygen saturation&gt; 92% and temperature &lt;38.5º, preserved cognitive (being able to respond to the examiner&apos;s command during the tests (Item 1 of the NIHSS) and application of resources), and who have Rankin previously referred (Rankin ? 2).	Patients with clinical and / or radiological deterioration within the first hour of admission to the stroke unit or direct admission to intensive care, documented pathological treatment, indication for immediate surgery, other serious or unstable medical illness, coronary disease, no response to voice will be excluded , Systolic blood pressure less than 110 mm Hg or greater than 220 mm Hg, oxygen saturation less than 92% with oxygen supplementation, resting heart rate less than 40 beats per minute or greater than 110 beats per minute, temperature greater than 38 ° C, or that has other interventions that prevent the protocol from being carried out	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-7d7ngw	Early prone position in patients on spontaneous ventilation	Recruiting	Intervention	2020-08-07	<NULL>	<NULL>	4101	Early prone position in spontaneous ventilation patients with respiratory failure secondary to COVID-19: randomized clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2020-07-15	Hospital Geral Roberto Santos	Hospital Geral Ernesto Simões Filho	https://ensaiosclinicos.gov.br/rg/RBR-7d7ngw	<NULL>	Patients will be included in surveys over the age of 18; are available hemodynamically; with arterial oxygen saturation greater than or equal to 94%; temperature below 38.5 degrees; Respiratory rate below 30 breaths per minute; who are on spontaneous ventilation to the environment or using oxygen support.	Patients who do not have a confirmed diagnosis of COVID-19 will be excluded; patients with severe acute arrhythmias; with a history of hemodynamic instability or recent cardiorespiratory arrest; Recent cardiothoracic surgery or unstable chest; Polytrauma with unstabilized fractures; Pregnant women; Recent abdominal surgery or stoma formation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-2vgq7y	Early pulmonary rehabilitation with elastic bands in patients with Exacerbated Chronic Obstructive Pulmonary Disease: Focus on cardiovascular health - vascular function	Recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3602	Early pulmonary rehabilitation with elastic bands in patients with Exacerbated Chronic Obstructive Pulmonary Disease: Focus on cardiovascular health - Cardiac arterial and autonomic function	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Carlos	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-2vgq7y	<NULL>	Clinical diagnosis of COPD who present exacerbation of the disease according to GOLD (contacted at least 24 hours and at most 48 hours after the start of standard therapy for exacerbation of COPD); spontaneous breathing at the time of the assessment, in conditions to maintain dialogue; those who agree to participate in the research in a free and informed manner.	Drug users who cause chemical dependency; patients with neurological and orthopedic changes; patients using invasive mechanical ventilation; hemodynamic instability; presence of unstable angina; hx of myocardial infarction in the last six months; other lung diseases; patients over the age of 85 years; and those who do not obtain a diagnosis of COPD after pulmonary function assessment, with ratio values ??(forced expired volume in the first second / forced vital capacity) greater than 0.7 and forced expired volume in the first second greater than 80%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-78gvj3g	Early refeeding after cesarean section: assessing the return of gastrointestinal function	Data analysis completed	Intervention	2023-08-24	<NULL>	<NULL>	6385	Early refeeding after cesarean section in a private hospital in Maceió: impact on the health of the maternal-fetal binomial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-06	Faculdade de Medicina da Universidade Federal de Alagoas	Unimed Maceio Cooperativa de Trabalho Medico (Hospital UNIMED)	https://ensaiosclinicos.gov.br/rg/RBR-78gvj3g	<NULL>	Parturients undergoing cesarean section; aged between 18 and 45 years; who were submitted to spinal anesthesia, under aseptic technique, followed by median puncture in the vertebral space between the third and fourth lumbar vertebrae with a 27G Whitacre needle, flowing clear cerebrospinal fluid and intrathecal injection of heavy bupivacaine 12.5mg plus morphine 60mcg	Patients with twin pregnancies; those with comorbidities resulting from pregnancy; patients with any type of perioperative intercurrence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-8333q9	Early skin to skin contact: effect on maternal stress and mother-child interaction	Recruitment completed	Intervention	2014-11-25	<NULL>	<NULL>	353	Early skin to skin contact: effect on maternal stress and mother-child interaction at 2 and 4 months corrected gestational age	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-12-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Pós-graduação em Ciências da Saúde - Saúde da Criança e do Adolescente / Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8333q9	<NULL>	Preterm newborns with birth weights between one thousand and eighteen hundred grams; preterm newborns stable in terms of respiratory and hemodynamic submitted or not in ventilatory support, between twenty four and seventy two hours of postnatal life; preterm newborns classified as appropriate for gestational age; mothers who did not show signs of psychological change	Preterm newborns with Apgar score less than seven at five minutes of life; newborns with congenital malformations; preterm newborns who had intraventricular hemorrhage and or hydrocephalus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-62prx9t	Early stimulation in motor development of premature babies: randomized clinical trials	Recruiting	Intervention	2022-03-14	<NULL>	<NULL>	5278	Effectiveness of early sensory-motor stimulation in neuropsychomotor development of premature newborns: randomized clinical trials	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-27	Universidade Estadual de Londrina	Programa de Pós-Graduação em Ciências da Reabilitação - UEL/UNOPAR	https://ensaiosclinicos.gov.br/rg/RBR-62prx9t	<NULL>	Preterm infants born at less than 32 weeks of gestational age (GA) or weighing less than 1500g at birth for a period of one year will be recruited. To be included in the study, newborns (NBs) need to be hemodynamically stable (respiratory rate 40-60 rpm, heart rate 120-160 bpm, peripheral oxygen saturation above 91%) and with no signs of respiratory distress.	Those who are using invasive or non-invasive mechanical ventilation, who cannot participate in the intervention for up to 3 consecutive days, who have congenital malformations, genetic syndromes, postoperative period and grade VI intraventricular hemorrhage will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-736jwh	Easier and less expensive ovarian stimulation for women at high risk for ovarian hyperstimulation: a randomized controlled trial	Recruiting	Intervention	2019-08-15	<NULL>	<NULL>	2876	Friendly and cost-effective ovarian stimulation for women at high risk for ovarian hyperstimulation syndrome: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Laboratório de Ginecologia e Obstetricia do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-736jwh	<NULL>	Infertile women; risk of ovarian hyperstimulation syndrome;  between 18 and 38 years; antral follicle count between 20 and 39	Weight less than 60 Kg or greater than 80 kg; partner with spermogram showing total sperm count less than 1 million; do not accept to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-106fywbx	Eating behavior and body image of adolescents participating in Mindfulness-based interventions	Not yet recruiting	Intervention	2023-04-29	<NULL>	<NULL>	6042	Eating behavior and body self-image of adolescents participating in Mindfulness-based interventions: a mixed methods study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-106fywbx	<NULL>	Age 15 to 19 years old	Evidence of severe depressive traits, anxiety, or stress, verified through the SCAS-BRASIL scale; Severe cognitive impairment, described through medical diagnosis; Presence of an eating disorder (anorexia, bulimia, binge eating disorder), described by medical diagnosis; Physical impairment that makes it difficult to perform the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-5yf2zv5	Eating-related issues and body image in candidates for bariatric surgery	Recruitment completed	Observational	2025-06-12	<NULL>	<NULL>	8043	Eating disorders, food addiction, body image, and related factors among Individuals undergoing bariatric surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-04-20	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5yf2zv5	<NULL>	Inclusion criteria will be individuals of both sexes; aged 20 years to 60 years old; with a body mass index (BMI) of 35 kg/m² or higher; regardless of the presence of obesity-related comorbidities	Exclusion criteria will include the presence of severe psychiatric disorders; genetic syndromes; active smoking; alcohol dependence or; substance abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-263nf22	EBRAHIP-120: Brazilian randomized controlled trial of uncemented and hybrid hip replacement surgery	Recruiting	Intervention	2024-12-16	<NULL>	<NULL>	7593	EBRAHIP-120: Brazilian randomized controlled trial of uncemented and hybrid hip arthroplasty.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-19	Suprema -  Sociedade Universitária para o Ensino Médico Assistencial	Hospital e Maternidade Therezinha de Jesus	https://ensaiosclinicos.gov.br/rg/RBR-263nf22	<NULL>	Inclusion criteria include age between 40 and 80 years old; with clinical and radiographic diagnosis of hip arthritis (both primary or secondary); uni or bilateral; both sexes	We will exclude patients with pathological fractures; metabolic and/or rheumatic diseases; patients with acetabular defects that require bone graft for correction; type III protrusio acetabuli deformity; patient with history of previous infection of the hip	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-8ys44sz	Education and technology as aid in weight loss	Recruitment completed	Intervention	2024-07-01	<NULL>	<NULL>	7112	Education in changing one&apos;s lifestyle to cope with excess weight with the use of information technologies	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-26	Fundação São Paulo - Campus Sorocaba da PUC-SP Fac Ciencias Med e da Saúde	Fundação São Paulo - Campus Sorocaba da PUC-SP Fac Ciencias Med e da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8ys44sz	<NULL>	Patients and staff registered at the Basic Health Unit of Parque São Bento, Sorocaba, São Paulo; both genders (male and female); aged between 20 and 59 years; diagnosed with overweight or obesity according to Body Mass Index classification; familiar with the use of mobile technologies such as WhatsApp on their smartphones; interested in the prevention and control of overweight and obesity through a healthy lifestyle	Individuals who chose not to participate in the project; lack of access or familiarity with mobile technology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-4qt84b	Education in pain and physical therapy for patients with chronic low back pain	Recruiting	Intervention	2018-11-13	<NULL>	<NULL>	2334	Physical therapy associated with pain neuroscience education for patients with chronic low back pain - blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-16	Centro Universitário Luterano de Palmas - CEULP/ULBRA	Centro Universitário Luterano de Palmas - CEULP/ULBRA	https://ensaiosclinicos.gov.br/rg/RBR-4qt84b	<NULL>	Patients referred from the Unified Health System (SUS) by the regulation system or registered at the of Physiotherapy’s School Clinical of the Lutheran University Center of Palmas (CEULP / ULBRA) that meet the following criteria: individuals older than 18 years; with chronic low back pain (over 3 months); of both sexes; score equal to or greater than 40 in the Central Sensitization Inventory.	Patients who are in legal proceedings against the company that working or worked; chronic diseases of systemic inflammatory origin; athletes; have performed surgical procedure in any region of the spine, have internal fixators in the spine, confirmed diagnosis of disc extrusion. Also excluded are patients with red flag criteria, such as history of neoplasms or tumor, human immunodeficiency virus (HIV), fever or infection in the last 30 days, sudden and severe weight loss, spine fracture, cauda equina syndrome and signs of neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-7h9mmy	Education on evidence-based health for journalism students	Recruitment completed	Intervention	2019-10-14	<NULL>	<NULL>	3082	"Medical journalism: evidence-based healthcare teaching for journalism students
as a tool to improve the quality of information"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-19	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7h9mmy	<NULL>	"3rd and 4th year undergraduate students in journalism or recent graduates in journalism in 2016 at Faculdade Cásper Líbero.
Spontaneously and voluntarily agreeing to participate in the educational intervention."	Do not agreeing to participate (as a volunteer)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-2nvf88f	Education on the management of drugs in the emergency car	Recruitment completed	Intervention	2024-09-27	<NULL>	<NULL>	7383	Management of drugs in the emergency car: an experimental study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-20	Residência em Enfermagem em Urgência e Emergência	Hospital Universitário da Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-2nvf88f	<NULL>	Volunteers aged 18 or over; working in the emergency department of the research institution; agreed to take part in the study and signed the informed consent form	Volunteers who were absent from work during the data collection period due to vacation, leave and/or any other reason. Volunteers who were absent or withdrew at any stage of the research were also excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-39xwyzr	Educational action for adults with type 2 Diabetes in primary care with a low-carbohydrate diet	Recruitment completed	Intervention	2025-03-10	<NULL>	<NULL>	7826	Educational intervention for adults with type 2 Diabetes in primary care on low-carbohydrate eating:a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Universidade Estadual do Oeste do Paraná	Prefeitura Municipal de Francisco Beltrão	https://ensaiosclinicos.gov.br/rg/RBR-39xwyzr	<NULL>	Patients diagnosed with Type 2 Diabetes without using insulin, aged between 40 and 89 years and with glycated hemoglobin levels equal to or above 6.5%. It may or may not have arterial hypertension as a comorbidity. Must have full access to the internet and have a smartphone application for individual or group communication	Those who have other forms of Diabetes, vegans, vegetarians, who have had bariatric surgery, with severe cardiovascular disease or diagnosed kidney disease, with a condition that affects their ability to participate, pregnant and lactating women, being on a weight loss program, in risk of an eating disorder or with a baseline glycated hemoglobin measurement of less than 6.5%	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-108vwpqd	Educational action TIV-disinfect (Intravenous Therapy-disinfect) for the hospitalized children and teenagers care	Recruitment completed	Intervention	2023-03-29	<NULL>	<NULL>	5972	Educational Intervention TIV-disinfect in pediatric units: quase-experimental study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-03-02	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-108vwpqd	<NULL>	Be a nursing professional; be attending patient units in pediatric services at the time of the study	Not answering the instrument in the pre-test; not answering the instrument in the post-test; not participating in the intervention as a whole; respondent the instrument incompletely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-3rs7sx	Educational actions on breastfeeding for pregnant women in limoeiro do norte	Recruitment completed	Intervention	2019-09-27	<NULL>	<NULL>	3004	Health education in the first quarter of pregnancy: promoting breastfeeding among pregnant women in limoeiro	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-03	Instituto Federal de Educação, Ciência e Tecnologia do Ceará	Instituto Federal de Educação, Ciência e Tecnologia do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3rs7sx	<NULL>	be pregnant in adulthood, from 19 years and up to 50 years; be in the first trimester of pregnancy. perform prenatal care at one of the ten basic health units in limoeiro do norte-ce.	pregnant women who answered the knowledge evaluation form incomplete; who gave up before the end of the educational activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-2gb34zr	Educational activities and group physiotherapy to prevent falls in the elderly	Not yet recruiting	Intervention	2021-02-11	<NULL>	<NULL>	4541	Education actions and group Physiotherapy at the risk of falls in the elderly: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-2gb34zr	<NULL>	Seniors; Age equal to or above 60 years; Gender-independent.	Bedridden; Wheelchair users; They use auxiliary device; Score equal to or less than 24 points in the Mini Mental State Examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-54vnnf	Educational game about breastfeeding for school children of primary school	Data analysis completed	Intervention	2017-05-19	<NULL>	<NULL>	1240	Educational technology about breastfeeding for school children of primary school	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-54vnnf	<NULL>	Children regularly enrolled in the third year of elementary school; attending school during the school calendar in the data collection period; in the age group from seven years; both genders; able to develop activities that include reading words and phrases; understand the guidelines for the development of activities explained by others.	Children who were separated due to illness or those with special needs, identified by the class teacher, that made it difficult to understand questions of the questionnaire and the information of the game, making it impossible to participate in the educational intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-937bj9r	Educational hypermedia for risk classification	Not yet recruiting	Intervention	2023-11-27	<NULL>	<NULL>	6610	Elaboration, validation and effects of educational software in embracement and obstetric risk classification	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Centro Universitário Inta	Centro Universitário Inta	https://ensaiosclinicos.gov.br/rg/RBR-937bj9r	<NULL>	Being a student regularly enrolled in the disciplines of Process of Care in Sexual and Reproductive Health (seventh semester) and Hospital Internship (ninth semester); Being regularly enrolled from the sixth semester; Being over 18 years old; Being attending the university during the period of data collection	Have previous practical experience in embracement and risk classification in obstetrics (students who carry out or have carried out extracurricular internships in this area)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-3g5f9f	Educational intervention by cell phone to increase informed choices at childbirth, in the context of the Covid-19 pandemic.	Not yet recruiting	Intervention	2020-07-29	<NULL>	<NULL>	4066	Communication intervention to improve informed choice at childbirth: a randomized controlled trial using digital technology in the context of the Covid-19 pandemic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-28	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3g5f9f	<NULL>	1) Be a registered user at PiniOn app; 2) Identify theirselves as women; 3) Be aged between 18 and 49 years; 3) Being pregnant or having biological children of any age or intending to have biological children in the future.	Women without children and with no intention of becoming a mother in the future will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-4qgpg5	Educational intervention for food consciouness in women	Not yet recruiting	Intervention	2020-09-29	<NULL>	<NULL>	4304	"Sensoriality as a marker of the relationship with food: education program
with sensory and cognitive exercises"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4qgpg5	<NULL>	The study population will consist of adult women (aged 20 to 59 years) with Body Mass Index between 18,5 and 34,9 kg/m², weight gain greater than 5% in the previous year and that refer desire to improve their relationship with food.	It will not be included pregnant or lactating women, smokers, diabetics, women using psychiatric drugs, nutritionists and women with a BMI of 35 kg/m² or greater (grade 2 obesity).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-8p9v7v	Educational Intervention in Breastfeeding	Data analysis completed	Intervention	2018-07-30	<NULL>	<NULL>	2067	Technology in Breastfeeding: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-16	Universidade Estadual de Campinas - UNICAMP	Hospital Samaritano de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8p9v7v	<NULL>	Being in the mid-term in the joint housing; Accept participating in the study for up to 60 days after the birth of the baby; Have a landline or cell phone; Be practicing Exclusive Breastfeeding during the stay in the joint accommodation.	Mothers of high and medium risk babies or premature infants who were not able to breastfeed;Puerperas with communication difficulties, whether due to hearing impairment or not speaking our language (Brazilian Portuguese).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-9w7kspz	Educational intervention in parental stress	Recruitment completed	Intervention	2022-08-16	<NULL>	<NULL>	5555	Efectiveness of Educational Intervention in parental stress in intensive care unit: experimental study	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-11	Universidade Federal do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-9w7kspz	<NULL>	Mother with newborn (NB) admitted to the Neonatal Intensive Care Unit - NICU of any age; does not have previous experience with a child hospitalized in the Neonatal Intensive Care Unit - NICU; attend the Neonatal Intensive Care Unit - NICU daily during the intervention; be a mother of a newborn - Newborn between 28 to 42 weeks of gestational age	Mothers of clinically stable newborns on admission and with the perspective of hospitalization in the Neonatal Intensive Care Unit - NICU within 72 h; mothers who present evidence of psychiatric disorders or/and evidence of psychoactive substance abuse; mothers of newborns - NB with structural (physical deformity, except polydactyly), functional (motor alterations) or metabolic (inborn errors of metabolism) congenital anomalies that can cause serious repercussions for the newborn; mother of a newborn who was born in another hospital and later admitted (after 72 hours of life); Mother of a newborn who has been or will undergo a surgical procedure; Mothers who will be discharged from the newborn before the second measurement of parental stress, being considered loss to follow-up; Mother who, during data collection, presents respiratory symptoms and/or is positive for SarS-cov-2 or reports a positive family member for Sars-cov-2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-8gd5g8	Educational intervention in the Adherence of the elderly to actions that prevent falls	Recruitment completed	Intervention	2019-12-17	<NULL>	<NULL>	3290	Effect of Educational intervention on Addressing elderly to fall preventive Measures: almost experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-8gd5g8	<NULL>	"Be 60 years and over;
Perform at least one of the physical activities offered by the Elderly Living Center."	To present cognitive and mental difficulty verified through the application of the Mini Mental State Examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-8kjtps	Educational intervention to promote a positive reaction to the adversities of adolescents in poverty	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3766	Education intervention to promote the resilience of adolescents in poverty situation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8kjtps	<NULL>	Public school adolescents; between 11 and 17 years old; minimum frequency of 75% in classes; being in poverty.	Some cognitive problem	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-8gzp4f4	Educational Practice on patient Safety: health experiment	Not yet recruiting	Intervention	2021-02-11	<NULL>	<NULL>	4543	Educational Intervention on patient Safety: quasi-experimental research	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8gzp4f4	<NULL>	"The population of interest will be composed of health users admitted to a hospital and the sample recruited from the medical clinic ward of the referred institution. Potentially eligible patients will first have the medical record analyzed by the researcher, considering as inclusion criteria:

- Be over 18 years old;
- Both sexes;
- Have clinical conditions to answer the questions and participate in the educational intervention (medical and nursing records must be included in the patients&apos; medical records that the patients are aware of, oriented, communicating without difficulty. The clinical conditions will be questioned by the researcher to the nurse or responsible physician, who must confirm that patients are not in a serious or clinically unstable state);
- Accept to participate in the research."	Patients who have an inability to understand the questions of the instruments and educational intervention (evaluated through the records in the patient&apos;s medical record).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-107hzdqt	Educational practice to encourage teenagers to vaccinate against HPV	Data analysis completed	Intervention	2021-06-23	<NULL>	<NULL>	4761	Educational intervention for adherence of adolescents to vaccination against Human Papilloma Virus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-107hzdqt	<NULL>	School girls aged nine to 14 years who did not have doses of HPV vaccine, as evidenced by the vaccination card.	Physical condition that made it impossible to respond directly to the data collection instrument.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-62sggb	Educational program to promote physical activity, cognitive and cardiorespiratory performance in sedentary older adults.	Recruiting	Intervention	2020-02-12	<NULL>	<NULL>	3485	Influence of an educational program to promote physical activity, cognitive and cardiorespiratory performance in sedentary older adults.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-16	Universidade Estadual de Ciências da Saúde de Alagoas	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-62sggb	<NULL>	Individuals aged 60 years; Sedentaries (&lt;150min of moderate physical activity per week); With subjective complaints of memory impairment or mild cognitive impairment; Agreement to sign the Informed Consent Form to participate in the research.	Illiterate; With health problems that can prevent safe walking; Patients with severe congestive heart failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-3jxmntz	Educational proposal for the Birthing workshop methodology for health professionals	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7315	Psychoeducational Proposal of the Birthing workshop methodology for primary care professionals	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-12	Universidade Santa Cecília - UNISANTA	Secretaria Municipal de Saúde de Santos	https://ensaiosclinicos.gov.br/rg/RBR-3jxmntz	<NULL>	For primary health care professionals - work directly in prenatal care for pregnant women; work in the health units proposed in the study; be 18 and over; agreement to participate in the research and signature of the Free and Informed Consent Form (ICF) - health professionals For postpartum women - having received prenatal care at the health units participating in the present study; nulliparous; be 18 and over; agreement to participate in the research and signature of the TCLE for postpartum women	Withdrawal from participating in the study at any time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-9ndj8xs	Educational strategy for the revention of Urinary Tract Infections in women in the prison system	Recruitment completed	Intervention	2024-11-01	<NULL>	<NULL>	7477	Health promotion and quality of life in the penitentiary system of Ceará	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-09	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9ndj8xs	<NULL>	Women; aged 18 years and above; incarcerated within the prison system regardless of the prison regime or time remaining to serve their sentence	Women with physical conditions that prevent participation in the study or responding to data collection instruments; women who refuse to respond to the general evaluation questionnaires and the initial Knowledge, Attitudes, and Practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-3yqmgtk	Educational strategy for truck drivers and control high blood pressure	Not yet recruiting	Intervention	2021-02-09	<NULL>	<NULL>	4531	Education strategy and control of arterial hypertension: a proposal for truck drivers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-21	Universidade de São Paulo - Escola de Enfermagem de Ribeirão Preto	Universidade Federal de Rondonópolis	https://ensaiosclinicos.gov.br/rg/RBR-3yqmgtk	<NULL>	Truck drivers with a clinical diagnosis of systemic arterial hypertension; who have a mobile phone with WhatsApp and Internet access.	Truck drivers who do not have a clinical diagnosis of systemic arterial hypertension; who do not have a cell phone; who do not have access to the internet; who have cognitive changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-3v4cj9	Educational technologies to promote the mother&apos;s confidence in breastfeeding: Clinical Trial with flipchart and Motivational Interview	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4299	Effects of intervention with educational technologies to promote maternal effectiveness when breastfeeding	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-22	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3v4cj9	<NULL>	Immediate puerperium; minimum 6 hours postpartum; 14 years of age or older; single term pregnancy; with newborn in rooming-in; newborn with capacity for effective suction and thermal control; have a telephone contact.	Adolescent without permission from parents or guardians; maternal or neonatal contraindication for breastfeeding; supposed cognitive limitation; hearing impaired.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-7qjpn6	Educational technology for nursing education	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3531	Educational technology for teaching nursing diagnostic reasoning	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7qjpn6	<NULL>	being a graduate student in nursing; and, be enrolled in the fourth period of the undergraduate nursing course at that University.	"Not participating in all phases of the research; and have taken some discipline on diagnostic reasoning in nursing at another institution
University education"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-103zbhkj	Educational technology on breast cancer prevention for healthcare professionals	Not yet recruiting	Intervention	2021-10-07	<NULL>	<NULL>	4948	Effectiveness of educational technology on breast cancer prevention for healthcare professionals: pragmatic randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-10	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-103zbhkj	<NULL>	Have one year of service in Basic Health Units; acting in assistance as the main professional activity; be a doctor, nurse, social worker, physical education professional or teacher, pharmacist, physiotherapist, speech therapist, physician, nutritionist, dentist, psychologist and occupational therapist.	Professionals on leave for any reason during the period of application of the research; do not serve women; do not have access to a device with an Internet connection; those who report not having time available; they gave up participating in the research after starting data collection; for some reason, they were absent from one of the data collection stages, demonstrating disinterest in continuing their participation, and refusing to continue in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-9595ds	Educational Video targeted to parents on neonatal Pain relief for newborn Screening Test	Not yet recruiting	Intervention	2017-06-28	<NULL>	<NULL>	1271	Effectiveness of an Instructional Video targeted to parents on neonatal Pain management for newborn Screening Test: a non-randomized, pragmatic clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-05	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9595ds	<NULL>	Mothers hospitalized in a rooming-in unit; who are fluent in Brazilian Portuguese; with preserved cognitive ability; whose newborns are eligible for neonatal screening, and can be breastfed, positioned on skin-to-skin contact or receive sweet tasting  solution.	Non-compliance in the technique of performing the neonatal screening test (two or than one puncture of calcaneus); blood sample for the neonatal screening collected through peripheral venipuncture or without the mothers&apos; presence; mothers and/or newborns who need hospitalization in another care unit during the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-8nfggd	Educational video to inform the elderly about the risks of falling: construction, validation and evaluation	Recruitment completed	Intervention	2020-01-27	<NULL>	<NULL>	4941	Effectiveness of educational video on the perception of elderly people about the risk of falling: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-31	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8nfggd	<NULL>	Be 65 years of age or older. Present without cognitive impairment, as evidenced by the application of the MMSE and do not present physical impossibility of locomotion to the UBS.	Be registered in the rural area of ??the municipality. Presenting hearing, visual or speech problems that could prevent the application of the instruments. Plan to move to another city before the data collection completion period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-5npmgj	Educational video to teach deaf people how to rescue someone who has had a cardiac arrest: construction, validation and evaluation	Recruitment completed	Intervention	2018-07-18	<NULL>	<NULL>	2022	Educational video for deaf people about basic living support: construction, validation and evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-17	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5npmgj	<NULL>	Be enrolled in any of the schools in which the data was collected; and have no illness or limitation that would make it impossible to watch the video or expository classroom	Have leave foreseen for the next 15 days (since the post test was also applied 15 days after the educational interventions); not complete the data collection instrument and do not have the physical conditions to participate in the practice of cardiopulmonary resuscitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-2f58ykv	Educational-care strategy for guidance on self-care, through a chatbot, for the Health Care Network and for people with intestinal stoma	Not yet recruiting	Intervention	2024-07-29	<NULL>	<NULL>	7162	Educational-care technological strategy for guidance on self-care, through a chatbot-type mobile application, to Health Care Network and for people with intestinal ostomies in State of Pernambuco	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-20	Fundação Universidade de Pernambuco	Complexo Hospitalar do Hospital Universitário Oswaldo Cruz/Pronto-Socorro Cardiológico Universitário de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2f58ykv	<NULL>	Age equal to or over 18 years old; have a colostomy or ileostomy; post-operative time from 1 to 4 months	Illiterate; psychiatric disorder; cognitive deficit; physical disability that compromises the practice of self-care; total or partial sensorimotor alteration; presence of peristomal dermatitis; presence of prolapse; presence of a hernia; presence of retraction; have received prior guidance on how to care for an intestinal ostomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-9yz2pb	Educative practice and maternal stress of premature infant: randomized clinical trial	Recruitment completed	Intervention	2016-01-29	<NULL>	<NULL>	702	Effects of prematurity: mother stress and metabolic programming after hospital discharge /Stress and maternal role after an educational intervention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	universidade estadual do oeste do parana - unioeste	Hospital Universitário do Oeste do Paraná - HUOP	https://ensaiosclinicos.gov.br/rg/RBR-9yz2pb	<NULL>	Preterm under 37 weeks of gestational age; preterm without malformation; teenager mother following with law responsable; literacy mother.	Preterm has left for adoption; mothers who have related psychiatric problems; mothers who autorelate that are in continuous use of controlled drugs (anxiety or depression); mothers with medical complications or who have gone to death during the study; illiterate mothers; teenagers mothers without law companion; mothers who did not attend the consultations on the follow-up clinic between the 3rd and 6th month after discharge from the Neonatal Intensive Care Unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-8sbbvp	Efect of Resistance Exercise Volume on Body Composition, Physical Performance, Metabolic, Hormonal and Inflammatory Profile in Postmenopausal Pre Sarcopenic Women	Recruitment completed	Intervention	2015-06-25	<NULL>	<NULL>	528	Sarcopenia: prevalence, disability and intervention in Postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-05-01	Universidade Federal do Triângulo Mineiro	Departamento de Ciências do Esporte	https://ensaiosclinicos.gov.br/rg/RBR-8sbbvp	<NULL>	34 postmenopausal healthy women with the last period of menstruation more than a year and age more than 50 years; no hormone replacement therapy; no resistance exercise practitioners or similars; no vegetarians or tabagist; no gynecologic disease; diabetes or cardiac; no regular use  medicine (aspirine or antibiotics) and no alcoholic.	Women period previous of menopause and age less than 50 years; hormone replacement therapy users; resistance exercise practitioners or similars; vegetarians or tabagist; with gynecologic disease; diabetes or cardiac disease; regular use  of medicine (aspirine or antibiotics) and alcoholic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8tsmfr	Efectiveness evaluation of Atraumatic Restorative Treatment with modified cement in children	Recruitment completed	Intervention	2016-10-19	<NULL>	<NULL>	1046	Evaluation of cost-benefit of Atraumatic Restorative Treatment with glass ionomer cement added cellulose nanocrystals in Brazilian children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-21	Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM	Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM	https://ensaiosclinicos.gov.br/rg/RBR-8tsmfr	<NULL>	Good general health; Presence of at least two vitals primary molars, without painful symptomatology	Uncooperative patients and/or with neurological problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-2xxp48	Efeito de bebida rica em fibra na redução da glicemia de diabéticos	recruitment completed	Intervention	2011-09-26	<NULL>	<NULL>	30	Effect of juice diet enriched with soluble fiber in reducing blood glucose of patients with diabetes mellitus type 2	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-07-01	Universidade Federal de Goiás	Ana Clara Martins e Silva Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-2xxp48	<NULL>	Inclusion criteria are: to be with diabetes mellitus type 2, has a body mass index above 25 kg/m2 and waist circumference increased, being sedentary, belong to the age group between 30 and 59 years and sign the Informed Consent Informed Consent (IC).	The exclusion criteria are: patients who are taking insulin, with chronic complications of diabetes, gastrointestinal disorders and intolerance fibers, pregnant and lactating women, and those who do not complete the follow-up during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2svpc94	Efeito of a digital game on physical activity and diet in adolescents	Not yet recruiting	Intervention	2022-05-12	<NULL>	<NULL>	5392	Impact of a digital game on physical activity and eating habits in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-21	Universidade Federal do Paraná	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-2svpc94	<NULL>	Volunteers healthy, with no health problems that prevent them from practicing physical activity; aged between 10 and 14 years old; enrolled in elementary school II (6th to 9th grade); have a minimum class attendance of 75%; have a Free and Informed Consent Form signed by parents or guardians before the beginning of the interventions; sign the Free and Informed Consent Form; have their own smartphone for the intervention.	Volunteers who withdraw from the research; do not adapt to the use of the exergame.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-2b4t4y2	Efeitos da Eletroestimulação Auricular Vagal em Fibromialgia	Not yet recruiting	Intervention	2025-10-29	<NULL>	<NULL>	8470	Effects of transcutaneous auricular vagal electrical stimulation in individuals with fibromyalgia: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-03	Universidade Estadual da Paraíba	<NULL>	<NULL>	<NULL>	Women; aged between 18 and 70 years; with a diagnosis of fibromyalgia (the diagnosis will be made by a physician referred by the patient and confirmed by a physical therapist with experience in rheumatology), taking into account the diagnostic criteria for fibromyalgia from the American College of Rheumatology.	Participants who are pregnant, have a history of epilepsy, have a metal implant, have undergone neurosurgery, have a psychiatric illness such as schizophrenia and bipolar disorder, otitis, and those with cognitive impairment expressed with difficulty in speaking and/or understanding and visual deficit that prevent the completion of the scales.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:39
RBR-8hhzfv9	"Efeitos da suplementação de arginina e beterraba desidratada na
função vasos sanguíneos de obrigação com Doença Pulmonar Obstrutiva Crônica relacionada à
pulmonar pulmonar"	Not yet recruiting	Intervention	2021-09-16	<NULL>	<NULL>	4890	"Effects of arginine supplementation and dehydrated beet consumption on
endothelial function of individuals with Chronic Obstructive Pulmonary Disease undergoing
pulmonary rehabilitation"	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2021-10-03	Federal University of Health Sciences of Porto Alegre	Pereira Filho Pavilion at the Santa Casa de Misericordia of Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8hhzfv9	<NULL>	Individuals of both sexes, age equal to or greater than 40 years, chronic obstructive pulmonary disease with moderate to very severe expiratory flow obstruction, clinical stability in the month prior to the study protocol	Food allergy to beet, strawberry flavoring or any other component of supplementation, current smoking, presence of associated diseases that make it impossible to carry out any of the evaluations, as osteoarthritis, serious cardiovascular diseases, severe neurological conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-3cr9jh	Effect  of cinnamon supplementation on body weight, body composition, lipid profile, blood glucose, inflammatory markers and thyroid hormones in postmenopausal women.	Data analysis completed	Intervention	2018-07-25	<NULL>	<NULL>	2058	Effect  of cinnamon (Cinnamomum zeilannicum) supplementation on body weight, body composition, lipid profile, blood glucose, inflammatory markers and thyroid hormones in postmenopausal women.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-3cr9jh	<NULL>	Women with 12 months of amenorrhea; overweight or obese; age between 45 and 59 years.	use of anticoagulants, anti-lipidemic, antihypertensive and oral hypoglycemic agents and insulin; patients with hepatic dysfunction; hormone replacement; who has had chemotherapy; who has allergy or hypersensitivity to cinnamon.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-2z4fkw	Effect and acceptance of a substance that causes early-stage caries of permanent molars to stop developing compared to a treatment with fluoride varnish.	Recruiting	Intervention	2019-04-08	<NULL>	<NULL>	2588	Efficacy and acceptability in the use of cariostatic compared to fluoride varnish in caries lesions in enamel in first permanent molars.	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2018-09-06	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-2z4fkw	<NULL>	"Children who present at least one active initial carious lesion (Score 1 and 2 of ICDAS II + LAA);
Detected by visual and tactile examination on occlusal surfaces of first permanent molars at different stages of eruption, will be included in the study."	"Absence of first permanent molars; 
Permanent permanent molars, restored or with carious cavity in enamel or dentin;
Children with systemic impairment and / or special needs;
Children who have other dental treatment needs will be referred to try vacancies specializing in Pediatric Dentistry and the Pediatric Dentistry Clinic of UnB;
In addition, all individuals will receive oral hygiene guidelines and eating habits."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-6m7tyhf	Effect and safety of 5% nicotinamide cream in the treatment of actinic keratosis	Recruiting	Intervention	2023-01-20	<NULL>	<NULL>	5838	Efficacy and safety of 5% nicotinamide cream in stabilizing the skin field cancerization: a randomized, double blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-09	Faculdade de Medicina Julio de Mesquita Filho	Fundo de Apoio à Dermatologia	https://ensaiosclinicos.gov.br/rg/RBR-6m7tyhf	<NULL>	Sign the Free and Informed Consent Form; age over 18 years of both sexes; present at least three and at most ten lesions clinically compatible with actinic keratoses on each forearm, bilaterally.	Actinic keratoses fewer than three or more than ten on each forearm; selected treatment area that has atypical clinical appearance or other extensive dermatoses on the forearms; presence of skin tumors in the treatment area; current and previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances being studied; patients using any systemic or topical immunosuppressant substance and oral retinoid; immunocompromised individuals; coagulation disorders; suspected or confirmed pregnancy; women of childbearing age not using contraceptive methods; breastfeeding women; previous treatments for actinic keratoses in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-9jwgkv	Effect and safety of Microneedling in the treatment of Frontal Fibrosing Alopecia	Recruiting	Intervention	2020-09-28	<NULL>	<NULL>	4297	Efficacy and safety of Percutaneous Collagen Induction by Needles in the treatment of Frontal Fibrosing Alopecia	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Hospital Universitário Walter Cantídeo Universidade Federal do Ceará	Hospital Universitário Walter Cantídeo Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9jwgkv	<NULL>	Patients with clinical diagnosis of Frontal fibrosing alopecia will be selected, including those with increased frontotemporal recess, associated or not with follicular papules and rarefaction of eyebrows; or histopathological diagnosis compatible with frontal fibrosing alopecia with follow up appointments at the Dermatology Department of  Walter Cantideo University Hospital.  Patients must be aged between 18 and 70 years old and must sign who the Informed Consent Form (ICF), with availability to attend periodic appointment evaluations.	Patients with the following conditions will be excluded: Pregnancy; Vitiligo, psoriasis or other skin diseases that present Koebner&apos;s phenomenon (development of chronic dermatosis in trauma areas); Active infections in the areas to be treated with microneedling; Presence of keloids in previous scars; History of allergy to topical or injectable anesthetic; Patients with psychiatric disorders or other clinical diseases that contraindicate the procedure; Patients who refuse to sign the Informed Consent Form (ICF) or who are unable to attend to periodic appointment evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-10gq99m4	Effect and safety of using a mixture of live bacteria that are beneficial to health to treat people with constipation and/or diarrhea and/or Irritable Bowel Syndrome	Recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6965	Double-blind, Randomized, Placebo-Controlled Clinical study of the performance and safety of using a Mixture of Probiotic Strains in the treatment of Changes in Bowel Habits and Associated Symptoms	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Farmoquímica S/A DIVCOM S/A	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10gq99m4	<NULL>	Aged between 18 and 60 years; diagnosed with constipation or diarrhea or Irritable bowel syndrome as per Rome Foundation &quot;Rome IV&quot; criteria (Appendix 3); BMI between 18.5 and 29.9 Kg/m2.	Severe psychiatric diagnoses; confirmed medical diagnoses of gastrointestinal tract disorders (such as Crohn&apos;s disease and ulcerative colitis; celiac disease;  small intestinal bacterial overgrowth); type I or II diabetes mellitus; history of gastrointestinal surgery; conditions that are known to cause changes in the gut microbiota (for example, opioid use, drug or alcohol abuse); if they are pregnant; breastfeeding; undergoing cancer treatment; taking laxatives; recently use of (in the last three months) probiotics (except for dairy and yogurt consumption) or symbiotics;  other medications or supplements that are known to affect intestinal movement (for example, antispasmodics, antidepressants, antacids); antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-6vp3srs	Effect and safety of using Pregabalin to reduce Pain after Hemorrhoid Surgery	Recruiting	Intervention	2025-09-01	<NULL>	<NULL>	8242	Efficacy and safety of perioperative use of Pregabalin in reducing Pain and Rectal Tenesmus after Hemorrhoidectomy: a randomized double-blind clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-05-05	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-6vp3srs	<NULL>	Patients over 18 years old; internal hemorrhoidal disease grades III and IV; preoperative hemorrhoidectomy at Hospital Carlos Macieira	Patients with a history of allergy to Pregabalin; who cannot adequately answer the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-45xmzj	Effect and tooth sensitivity caused by the use of hydrogen peroxide gel in at-home bleaching - clinical study.	Recruitment completed	Intervention	2015-10-09	<NULL>	<NULL>	628	Randomized clinical trial on the efficacy and tooth sensitivity of different concentrations of hydrogen peroxide.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-16	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-45xmzj	<NULL>	Patients older than 18 years; good oral and general health; free maxillary anterior teeth restorations and do not carious lesion present; have the color of A2 or darker teeth according to the color scale Classical Vita (Vita Zahnfabrik, Bad Säckingen, Germany).	Patients who already underwent tooth whitening; pregnant or lactating patients; who report tooth sensitivity; staining tetracycline; fluorosis or endodontics; with parafunctional habits, patients with dental prostheses; appliances orthodontic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-6dv55j	Effect for the health, well-being and sleep of military personnel through ice cream containing beneficial bacteria	Recruitment completed	Intervention	2020-07-06	<NULL>	<NULL>	3979	Effect of Supplementation with Synbotic Ice Cream on the immune response, health in general and parameters related to the gut-brain axis in military submitted to field training	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2019-03-07	Faculdade de Ciências Aplicadas - Universidade Estadual de Campinas	Instituto de Tecnologia de Alimentos	https://ensaiosclinicos.gov.br/rg/RBR-6dv55j	<NULL>	Military student in Army Cadets Preparatory School (EsPCEx); aged between 18 and 22 years; participation in field training activities	Military with age below 18 years and above 22 years; lactose intolerance and allergy to milk proteins or to any of the other ingredients used in the product (emulsifier, vanilla extract, inulin); being immunosuppressed or having undergone any organ transplant, as well as any type of heart disease; antibiotic use by volunteers within 15 days before the start of supplementation; need for any type of surgery, tooth extraction or other types of dental manipulation, during the experimental period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-5hz86t	Effect ingest of Hibiscus sabdariffa tea on energy metabolism, subjective satiety responses and food intake of healthy individuals.	Recruitment completed	Intervention	2020-04-30	<NULL>	<NULL>	3796	Effect of ingestion of supposedly thermogenic teas on metabolism energy, feeling full and eating in individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5hz86t	<NULL>	BMI between 18.5 to 26kg / m2; stable weight in the last 3 months; no use of dietary supplements or medications except oral contraceptive; non-smokers.	Diabetics; hypertensives; carriers of diseases that interfere with energy metabolism; allergic or with some sensitivity to standardized breakfast ingredients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-5db955	Effect of  exercise training on clinical markers ,quality of life and mental health in women with polycystic ovary syndrome	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4075	Brazilian Study on Polycystic Ovary Syndrome (PCOS)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Departamento de Educação Física	Departamento de Toco-Ginecologia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5db955	<NULL>	Age between 18 to 40 years; (2). Body mass index greater than or equal to 18.5 kg / m² and less than 40 kg / m² (3). Diagnosis of PCOS; (4); without physical exercise in the last six months or sedentary;	(1). Pregnant women; (2). They present androgen-secreting tumors, Cushing&apos;s syndrome, congenital adrenal hyperplasia, hyperprolactinemia (greater than 40ng / ml) and thyroid dysfunction; and (3). Diabetes mellituS; (4).one positive response on the PAR-Q or any other contraindications for physical activity, as determined by a medical history.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-8vyxcfk	Effect of 0.12% Chlorhexidine mouthwash and 5% Malva sylvestris solution on dental plaque and gingival inflammation	Recruiting	Intervention	2023-08-22	<NULL>	<NULL>	6367	Antiplaque and antigingivitis efficacy of 0.12% Chlorhexidine mouthwash and 5% Malva sylvestrais: A randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-08	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8vyxcfk	<NULL>	systemically healthy; both sex; over 18-year-old; with more than 19 teeth present	Presenc of allergies to the components/products used (chlorhexidine digluconate 0.12%, Malva sylvestris extract 5%); use of 0.12% chlorhexidine digluconate or other mouthwash in the last 21 days; use of fixed and/or removable prostheses; being under orthodontic treatment; presence of caries lesion; presence of esthetic or poorly adapted restorations; presence of lesions on the oral mucosa; presence of active infectious focus (endodontic abscesses); presence of marginal gingival bleeding more than 10%; history of periodontitis (interproximal attachment loss more than 3mm in two or more non-adjacent teeth); presence of diabetes or immunosuppression; pregnant or breast-feeding patients; smokers; use of local or systemic antimicrobials in the last 90 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-296z9hd	Effect of 12 weeks of a training program with muscle strength exercises in open and closed kinetic chain on postural control performance, muscle activation and lower limb muscle power	Not yet recruiting	Intervention	2026-04-28	<NULL>	<NULL>	9146	Effect of a 12 week training program with muscle strength exercises in open and closed kinetic chain on postural control performance, muscle activation and lower limb muscle power: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Healthy older adults; Age equal to or greater than 60 years; Residents of João Neiva, Espírito Santo, Brazil;Young adults; Age between 18 and 35 years; Healthy	Neurological diseases; Dependent gait; Altered cognitive functions; Depressive symptoms; Auditory or vestibular impairment; Inability to perform strength training	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-47kkgyk	Effect of 16 weeks of different training strategies on health status in individuals with Heart Failure	Data analysis completed	Intervention	2021-03-31	<NULL>	<NULL>	4593	"Analysis of the impact of different types of Physical Exercise on exercise tolerance and
quality of life in individuals with heart failure"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Instituto Estadual de Cardiologia Aloysio de Castro	Instituto Estadual de Cardiologia Aloysio de Castro	https://ensaiosclinicos.gov.br/rg/RBR-47kkgyk	<NULL>	Diagnosed with HF 1 year ago; any etiology; both sexes; older than 18 years; presenting an ejection fraction of less than 50%; clinically stable; no change in medications in the last 3 months.	Pregnancy and breastfeeding; presenting an injury that impairs the performance of the exercises; show signs of ischemia or major ECG abnormality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-44q9k6q	Effect of 17% Glycolic Acid in Primary Endodontic Treatment: Randomized Clinical Trial	Recruiting	Intervention	2023-10-17	<NULL>	<NULL>	6514	Effect of 17% Glycolic Acid on Periapical Healing in Primary Endodontic Treatment: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-31	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-44q9k6q	<NULL>	Healthy volunteers; both genders; non smokers; previously initiated endodontic therapy	Smoking volunteers; history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies, endodontic retreatment, root resorption, immature/open apex, root canal where patency of the apical foramen cannot be established	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-1083qqwy	Effect of a 35% hydrogen peroxide gel containing a composite in reducing of tooth sensitivity after in-office dental bleaching	Recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6325	Effect of the use of a 35% hydrogen peroxide gel containing capsaicin and hydroxyapatite nanoparticles to reduce post-bleaching tooth sensitivity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-20	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-1083qqwy	<NULL>	Patients aged between 18 and 50 years; both genders; with good oral and general health; have their maxillary anterior teeth free from restorations and carious lesions; canines with color A2 or darker according to the Classical Vita scale (Vita Zahnfabrik, BadSäckingen, Germany); to agree with the free and informed consent form	Patients who have already performed dental whitening; pregnant patients or lactating; severe browning (staining by tetracycline; fluorosis or endodontics); people with dental prostheses and orthodontic appliances and any other oral pathology; patients who have gastric, heart, kidney and liver problems; diabetes; hypertension; who are making continuous use of drugs with analgesic and anti-inflammatory action	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-4vp7gw	Effect of a balance training in the postural control in patients during hemodialysis	Recruiting	Intervention	2019-09-18	<NULL>	<NULL>	2964	Effect of a balance training in the static postural control in patients during hemodialysis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-20	Universidade Federal de Juiz de Fora	Faculdade de Fisioterapia UFJF	https://ensaiosclinicos.gov.br/rg/RBR-4vp7gw	<NULL>	Volunteers in hemodialysis for at least 3 months; both genders; at least 18 years old; agrred to sign the consent form	Volunteers presenting cognitive impairment; physical impairment;  unstable and severe comorbidities; hospitalization in the last 3 months before teh study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-3t38hq2	Effect of a beam walking training on balance control during gait in older adults with a history of falls: a randomized clinical trial	Not yet recruiting	Intervention	2025-04-01	<NULL>	<NULL>	7874	Effect of beam walking training on dynamic balance control during locomotion in even and uneven terrains in older adults: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3t38hq2	<NULL>	Men and women; age between 65 and 80 years; intellectual capacity to understand verbal commands and perform tasks; ability to stand and walk independently without the use of assistive devices; older adults who have experienced at least one fall in the last six months; a MiniBEST test score below the cutoff point for fall risk, adjusted for age	Uncontrolled severe musculoskeletal, sensory, neurological, or cardiovascular problems; visual impairments not corrected by glasses or lenses; cognitive deficits such as alzheimer&apos;s, dementia, and other conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-5w9tx9	Effect of a board game on the knowledge of the elderly about HIV / AIDS prevention	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4316	Effectiveness of a board game on the knowledge of elderly people in a school context about HIV /Aids prevention	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-04-02	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5w9tx9	<NULL>	Be sixty years old or over; be regularly enrolled in schools that have the EJA modality in Health District IV and have at least six months of study at EJA.	Elderly people who are enrolled but are not attending classes during the data collection period provided for by this study; elderly people who have had cognitive impairment assessed using the 6-item cognitive decline test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-6bzfrn	Effect of a calming medication on reducing anxiety before wisdom tooth removal	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4170	Effectiveness of sublingual alprazolam in reducing anxiety in impacted third molar surgery - controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Hospital Universitário da Universidade Federal de Sergipe	Hospital Universitário da Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6bzfrn	<NULL>	Patients over 18 years; Systemically healthy patients;Presence of asymptomatic impacted third molars; third molars classified as IIB by Pell and Gregory Classification.	Pregnancy or lactation; History of Allergies to drugs or substances used in this experiment; Patients on therapeutic use of psychiatric drugs; menstrual period women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-3ndqws	Effect of a caries paralyzing substance on deep cavities of milk molars compared to a caries obturator treatment	Recruiting	Intervention	2017-08-02	<NULL>	<NULL>	1316	Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-20	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3ndqws	<NULL>	Children aged 2 to 5 years;who are in good general health;who have at least one active dentin carious lesion on the occlusal surface of primary molars corresponding to ICDAS codes 5 or 6.	Children with systemic or neurological diseases;whose families intend to move from Rio de Janeiro next year;with a history of allergy to silver or any substance present in the different materials to be used for treatment. Besides that, teeth with spontaneous or provoked pain, dental mobility or radiographic signs of involvement or possible pulp involvement;shows possible pulp involvement by radiographic examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-9hnftg	Effect of a chitosan-chamomilla microparticle formulation in the prevention of radiation dermatitis	Data analysis completed	Intervention	2019-08-26	<NULL>	<NULL>	4848	Effect of a chitosan-chamomilla microparticle formulation in the prevention of radiation dermatitis: a randomized controlled phase II clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2019-01-23	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-9hnftg	<NULL>	18 years older; confirmed diagnosis of breast cancer; indication of radiotherapy treatment; Not having started radiation therapy; non-history of allergic reactions to any other component of chamomile or lanolin; non-history of allergic reactions to fish, shrimp or seafood; Kanofsky greater than 70; No use of systemic corticosteroids. do not use heparin, oral anticoagulants and antiplatelet agents.	Present any injury at the treatment site; present skin involvement by the tumor;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-9b6kvp	Effect of a Cloth Mask Physical Exercise session on Cardiovascular health, Feeling and Exercise Effort, Oxygen Quantity and Jumping Performance: Recommendation for Physical Mask Exercise during and after the COVID-19 global outbreak	Not yet recruiting	Intervention	2020-10-29	<NULL>	<NULL>	4353	Acute and Sub-acute Effect of the Use of Cloth Mask During Exercise on Cardiovascular Parameters, Psychophysiological Responses, Oxygen Saturation and Specific Performance: Recommendation for the practice of physical exercise with a mask during and after the global outbreak of COVID-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-02	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9b6kvp	<NULL>	the athlete cannot have a recent history of injury and rehabilitation in the last 3 months; have respiratory diseases (e.g., asthma); the group with previous experience in aerobic training must train at least 30 minutes a day and 3 days a week; and the group not involved in a training program must not have carried out any form of systematic training for at least 6 months; age between 18 and 65 years;	Individuals who do not complete the assessments to be carried out or miss any of the exercise sessions will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-9pjkgw	Effect of a complementary practice that uses comedy films during the dialysis procedure in the levels of stress, anxiety, depression and quality of life.	Recruitment completed	Intervention	2019-04-11	<NULL>	<NULL>	3821	Effect of a complementary practice based on comedy films during hemodialysis in the levels of stress, anxiety, depression and quality of life.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-9pjkgw	<NULL>	be over 18 years old; being on hemodialysis for at least three months at the clinic, performing the procedure three times a week.	Patients who do not agree to participate in the study; those with acute renal disease; patients who find it difficult to understand the issues of the instruments; patients who do not carry out routine hemodialysis follow-up at the reference center (they are hemodialising eventually due to displacement or other need) and patients who do not present stable clinical conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-243gf6	Effect of a controlled release system of doxycycline for control of periodontal disease	Data analysis completed	Intervention	2017-10-23	<NULL>	<NULL>	1437	Effect of a controlled release system of doxycycline for control of periodontal disease: randomized double masking clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2014-02-02	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-243gf6	<NULL>	Individuals presenting chronic periodontitis (AAP-1999); individuals with contralateral quadrants containing at least one molar with presence of sites with probing depth 5 mm, clinical insertion level 6 mm and bleeding at probing; over 18 years.	Presence of periapical and pulpal alterations; presence of gingivitis and acute periodontal conditions (abscesses and acute necrotizing periodontitis); presence of candidosis and changes in the mucosa; allergy to the components of gels and periodontal dressings; presence of systemic diseases (cardiovascular, blood dyscrasias, immunodeficiencies, transplanted, diabetes, osteoporosis, nephropathies, hepatopathies); need for antibiotic prophylaxis before periodontal treatment; use of systemic antibiotics, chemotherapeutics of controlled or continuous use and others that may interfere with the inflammatory process or have adverse effects directly in the periodontium in the last 6 months; pregnancy and contraceptive users during the study and during the previous three months or lactation; smokers; surgical or non-surgical periodontal treatment in the last 6 months; treatment with chlorhexidine mouthwash 0.12% or other topical chemical agent in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-7466htj	Effect of a Counseling Program on Depression symptoms and physical activity, sedentary behavior, and sleep in adults with depressive symptoms	Recruitment completed	Intervention	2023-04-17	<NULL>	<NULL>	6577	Effectiveness of a Counseling Program on Depression symptoms and 24-hour movement behaviors in adults with depressive symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7466htj	<NULL>	Be a volunteer; score ≥ 9 points on the Patient Health Questionnaire-9 (PHQ-9); be aged between 20 and 59 years; have an electronic device with a camera and microphone installed, such as a computer, tablet or cell phone; have access to the internet; have availability for days and times of online and face-to-face meetings	Present a need for specialized psychiatric treatment, ignoring cases of depression (eg, psychosis, schizophrenia); present suicidal risk (scoring 2/3 in the PHQ-9 suicidal risk question); present change in antidepressant medication in the month prior to recruitment or during the intervention; having diseases or physical limitations that prevent participation in the study; being pregnant or being in the puerperium	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-7nx3kwp	Effect of a dental floss impregnated with chlorhexidine in adults with Gingivitis	Recruiting	Intervention	2022-08-02	<NULL>	<NULL>	5527	Efficacy of a dental floss impregnated with chlorhexidine in adults individuals with gingivitis: a randomized controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-02-18	Universidade Federal de Pelotas	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7nx3kwp	<NULL>	Men and women at least 18 years of age; avaliable to participate in all phases of the study; good general systemic health; have at least 20 natural teeth present, with the exception of third molars; contiguous interproximal spaces with indication for flossing; have a diagnosis of biofilm-induced gingivitis, with the presence of bleeding gingival in at least 10 percent of the sites examined; being right-handed	Individuals with moderate periodontitis according to the criteria Eke et al 2012, defined as at least two interproximal sites with attachment loss of at least 4mm not on the same tooth or at least two interproximal sites with a depth of probing of at least 5mm not in the same tooth; individuals with severe periodontitis according to the criteria of Eke et al. 2012, defined as at least one interproximal site with probing depth of at least 5 mm and at least 6 mm attachment loss, in at least two interproximal sites, indistinct teeth; individuals who smoke or who have quit smoking for less than one year; individuals with the presence of biofilm retentive factors, except calculus supragingival; those who used systemic antibiotics in the three months prior to the carrying out the study; carriers of any systemic changes, such as diabetes and hormonal disorders with periodontal repercussions; individuals who need to use antimicrobial chemoprophylaxis to receive dental treatment; have undergone periodontal treatment in the last six months; have used chlorhexidine in the last three months; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-3hknrw	Effect of a Diet with fewer Calories and a low-Meat diet in the metabolism of humans	Recruiting	Intervention	2018-07-26	<NULL>	<NULL>	3033	Study of the metabolic and molecular changes involved in Caloric Restriction and in the Hypoprotein Diet in humans	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-10	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3hknrw	<NULL>	Volunteers of both genders; non smokers; age between 30 and 60 years who present type 2 diabetes mellitus, who do not use insulin and who present dyslipidemia.	Volunteers with BMI above 35, smokers and who use insulin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-2dwbjg	Effect of a dietary supplement on fatigue and quality of life of women with Breast cancer	Recruiting	Intervention	2019-07-24	<NULL>	<NULL>	2846	Effect of Paullinia Cupana on fatigue and quality of Life of women with Breast cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-2dwbjg	<NULL>	Individuals of the female gender; age group greater than or equal to 30 years and up to 59 years in any antineoplastic treatment; living in the city of São Luis. Disease stage I to III.	Men or women pregnant or in stage four of the disease. Age under 30 or greater than 59 years. Individuals who can not communicate verbally or move. With mental disorders; grade three to four nausea; anorexia or do not want to continue in the study or have any kind of complication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-5vwj4y	"Effect of a Fluoride Varnish on the Prevention of Dental Caries in permanent teeth:
randomized clinical study of 18 months"	Recruitment completed	Intervention	2017-10-18	<NULL>	<NULL>	1430	Effect of a TiF4 Varnish in the Prevention and Remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-03	Universidade de São Paulo	Faculdade de Odontologia de Bauru - FOB/USP	https://ensaiosclinicos.gov.br/rg/RBR-5vwj4y	<NULL>	Signature of parents or guardians, the Informed consent. Present active white spot lesions (scale 1 Nyvad et al., 2003) on smooth surfaces of at least two teeth in the initial clinical examination.	users of orthodontic appliances; That participated in another clinical trial within 3 months prior to the selection or subjected to professional fluoride application in the last 6 months; treatment with antibiotics or some other type of medicine (with chronic diseases);with periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-5pkbmw7	Effect of a green tea and hyaluronic acid-based gel and an adhesive dressing on the repair of gingival graft donor beds	Recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8736	Effect of a green tea and hyaluronic acid-based gel and an adhesive dressing on the repair of gingival graft donor beds. Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Age between 18 and 60 years; Good oral hygiene (Plaque Index &lt; 20%); Systemic health; Probing depth less than 3 mm in the affected areas of the recipient site; Isolated or multiple gingival recession with interproximal tissue filling the entire interproximal space; Absence of keratinized mucosa associated with teeth or dental implants	Patients with periodontal disease; Patients with systemic diseases or conditions or who use medications that alter bone metabolism (except for compensated diabetics); Uncontrolled diabetics (glycated hemoglobin above 8%); Pregnant or breastfeeding women; Heavy smokers (more than 10 cigarettes per day); Patients who use illicit drugs; Presence of periapical lesions; Patients who have used corticosteroids, chemotherapeutic agents, and immunomodulators in the last 6 months; Patients who did not agree to return for follow-up	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-9svwrv	Effect of a Green Tea&apos;s Catechin on Appetite in healthy women	Recruitment completed	Intervention	2017-09-28	<NULL>	<NULL>	1405	Effects of Acute Supplementation with Epigalocatequine 3 Galate (EGCG) on Appetite&apos;s Modulation in healthy women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Universidade Federal de Goiás	Gustavo Duarte Pimentel	https://ensaiosclinicos.gov.br/rg/RBR-9svwrv	<NULL>	The study population will be composed of healthy; eutrophic women (BMI between 18.5 kg/m2 and 24.9 kg/m2; aged between 20 and 30 years.	Women with a BMI of less than 18.5 kg m2; BMI greater than 24.9 kg/m2; carriers of immune diseases; use of immunosuppressive drugs; clinical diagnosis of diabetes; thyroid dysfunction; chronic kidney disease or liver disease; to have  had  bariatric procedure prior to the study; Are chronic alcoholics; Use medications that modulate hormonal functions (eg, contraceptive); medicines that affect appetite; medicines that affect body weight (eg, inhibitors) in the last 12 months; Have participated in any food restriction program; have been using nutritional supplements in the last 12 months; Have a feverish state in the weeks of the research; Have not followed the stipulated protocol for data collection; have refused to carry out any of the proposed evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-2yjtsn	Effect of a Health Education Program on the knowledge and training of pelvis muscles in women in the treatment of urinary loss	Not yet recruiting	Intervention	2020-03-30	<NULL>	<NULL>	3684	Effect of a Health Education Program on the knowledge and training of pelvic floor muscle in women in the treatment of Urinary Incontinence of Effort: a randomized study	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2019-08-12	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2yjtsn	<NULL>	The study will include women with complaints of urinary loss; over 18 years; who have never received training for MAP; who can read and write and understand the Portuguese language	Those who report or present any psychiatric disorder; cognitive deficit; neurological or incapacitating disease; who are pregnant, last child less than a year and previous surgery to correct UI; will be excluded; regardless of the time that was performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-8y8b45	Effect of a health guidance program on decreasing muscle complaints in workers who use the computer for long periods	Recruitment completed	Intervention	2020-02-06	<NULL>	<NULL>	3454	Effect of a health education program on reducing musculoskeletal complaints in long-term computer workers: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-09	Centro Universitário Cesmac	Centro Universitário Cesmac	https://ensaiosclinicos.gov.br/rg/RBR-8y8b45	<NULL>	Active worker volunteers who use computers for at least four hours a day; both sexes; age between 18 and 59 years.	Pregnant volunteers; Volunteers reporting musculoskeletal pain or injury due to infectious, genetic or traumatic disease and / or disorder; Volunteers who have a physical or mental disability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8c52hn5	Effect of a herbal medicine on body weight and metabolism in postmenopausal women	Recruitment completed	Intervention	2022-07-15	<NULL>	<NULL>	5489	Effect of Dicrostachys glomerata extract on body weight and cardiometabolic markers in postmenopausal women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-13	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8c52hn5	<NULL>	Women; age between 45 and 65 years; in post-menopause; overweight; or obesity	Participants who do not sign the Free Informed Consent form; women who have received hormone therapy in the last 6 months; surgery-induced menopause; with untreated hypothyroidism; presence of kidney or liver diseases; any type of cancer; and with inflammatory or infectious disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-2tjqwwj	Effect of a high intensity training program with different protocols in the pool environment on physical capacities, body composition (lean weight and fat weight), heart rate and blood pressure.	Not yet recruiting	Intervention	2021-03-28	<NULL>	<NULL>	4587	"Effect of a high intensity interval training program with different
physical exercise protocols performed on the ground and within the aquatic environment
on variables, metabolic, hemodynamic, anthropometric and functional."	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-05	Escola Superior de Educação Física	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2tjqwwj	<NULL>	Physically active men; Be aged between 18-25 years; Not having a history of musculoskeletal injury; Not presenting diagnoses of cardiometabolic diseases; Answer NO to all questions in the Physical Activity Readiness Questionnaire (PAR-Q) and Sign the free and informed consent form (ICF).	Not attending the evaluation calendar; Present any major injury or discomfort that makes it impossible to continue the research and Start another physical exercise practice during the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-774xbd	Effect of a homemade salivary substitute prepared with Chamomile and Linseed in relieving the burning sensation in the mouth	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3459	"Effect of a homemade salivary substitute based on Chamomile (Matricaria chamomilla) and
Linseed (Linum usitatissimum) in relieving the symptoms of Burning Mouth Syndrome"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-20	Faculdade de Odontologia Universidade Federal de Pelotas	Faculdade de Odontologia Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-774xbd	<NULL>	Women over 40 diagnosed with BMS by an oral medicine specialist according to the international classification of headache disorders; complaining of an intraoral burning sensation for more than 2 hours for more than three months; clinically normal oral mucosa; without signs of neuropathies involving other pathologies; without articular function; normal blood samples (red blood cell and leukocyte count, C-reactive protein levels, normal levels; no anemia); in the case of previous treatment for BMS it must have been included ineffective and discontinued for a minimum period of 2 months before being included in the study	Women with oral lesions or systemic diseases associated with BMS; Women in current treatment for BMS; Women with a glycated hemoglobin level (hemoglobin A1C)&gt; 7%; pregnant women; women being treated with corticosteroids; women with lesions in the oral mucosa or patients with dental prosthesis; women with anemia, Sjoegren&apos;s Syndrome or another Autoimmune Diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-65kd9hb	Effect of a intensive training in improving the use of the legs of individuals with incomplete spinal cord injury	Not yet recruiting	Intervention	2026-03-24	<NULL>	<NULL>	9008	Effect of Rehabilitation based on Activity Constraint-Induced Therapy for people with Spinal Cord Injury (ReACIT-SCI) in improving the use of the lower extremities of individuals with incomplete Spinal Cord Injury	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade do Estado de Santa Catarina	<NULL>	<NULL>	<NULL>	To be eligible, participants must: have an incomplete motor spinal cord injury of any neurological level and any etiology; have a chronic spinal cord injury, i.e., more than six months since the injury, with no upper time limit; be between 18 and 50 years old; be able to walk at least ten meters, with or without a walking aid, but without assistance from others; have a walking speed between 0.20 m/s and 1.00 m/s; be available to perform at least 75% of the in-person protocol and homework assignments; and have the possibility and ability to cancel other interventions aimed at improving mobility during the study period.	Insufficient level of understanding and communication to complete the Lower Extremity Motor Activity Log without assistance in less than 30 minutes, as therapists will administer the instrument daily during the intervention and need to complete it within this pre-established time; and some musculoskeletal, cardiorespiratory, or neurological condition not associated with spinal cord injury that has a direct effect on independence for mobility activities.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-8bhgyg8	Effect of a Laser protocol on Postoperative Pain reduction in Root Canal treatment: A Pragmatic Clinical Trial	Recruiting	Intervention	2025-07-01	<NULL>	<NULL>	8091	Effect of a Photobiomodulation protocol on the reduction of Postoperative pain in Endodontic Treatment: a pragmatic clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Faculdade de Odontologia da Universidade Federal do Amazonas	Universidade Federal do Amazonas (UFAM)	https://ensaiosclinicos.gov.br/rg/RBR-8bhgyg8	<NULL>	Competent adult patients; both genders; aged between 18 to 65 years; with referral for endodontic treatment in permanent teeth from public healthcare services with referral documentation; patients with contact number	Patients at any gestational stage; immunocompromised or with special needs; teeth presenting endodontic complications; teeth with calcifications; teeth with external or internal resorptions; incomplete root formation; teeth with dental perforations; teeth with longitudinal or vertical fractures; severe periodontal disease; teeth not completed in a single session	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-10wpdd9c	Effect of a lifestyle change program for the treatment of Obesity with online and in person support	Recruitment completed	Intervention	2024-01-10	<NULL>	<NULL>	6718	Effect of a hybrid program of intensive lifestyle change in the treatment of Obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Hospital das Clínicas da Faculdade de Medicina de São Paulo	Hospital das Clínicas da Faculdade de Medicina de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10wpdd9c	<NULL>	Minimum age of 18 years; body mass index (BMI) equal to or greater than 30; have a smartphone with internet access	patients not adhering to the project proposal; undergoing bariatric surgeries; pregnant women; breastfeeding women; illiterate individuals; people with endocrine diseases; genetic syndromes that cause obesity; cognitive deficit; uncontrolled psychiatric illness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-1088cyz6	Effect of a Mindful Eating program in patients with Fatty Liver	Recruiting	Intervention	2026-03-05	<NULL>	<NULL>	8949	Effect of a Mindful Eating program in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-30	Faculdade de Medicina da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Patients diagnosed with Metabolic Dysfunction-Associated Steatotic Liver Disease - MASLD by imaging method or liver biopsy; age between 18 and 65 years; agreement to participate in the study and signing of the Informed Consent Form; both sexes	Age over 65 years of both sexes; illiterate individuals; diagnosis of decompensated liver cirrhosis or Child-Pugh B or C; patients with liver cancer; individuals who do not have digital skills; individuals who have practiced mindfulness, meditation or yoga in the last 6 months (with regular practice of at least 3 times a week); individuals who are in an acute phase of depression and/or have a high score on the Depression Anxiety Stress Scale - 21 items (DASS-21); individuals diagnosed with schizophrenia and at suicide risk; pregnant women; individuals with untreated hypothyroidism and/or hyperthyroidism, Cushing&apos;s syndrome and individuals who have undergone bariatric surgery (less than 5 years ago); patients who have not participated in the leveling session to start the groups; patients who have been using orlistat, bupropion hydrochloride and Glucagon-Like Peptide - 1 (GLP-1) analogues for less than 6 months or whose dose has been modified in the last 6 months; patients using tamoxifen, methotrexate, corticosteroids, amiodarone and sodium valproate; women with alcohol consumption greater than 20g/day (140g/week) and men with consumption greater than 30g/day (210g/week); patients who have obtained a score below stage 3 (preparation) in the readiness for change questionnaire; patients who have had weight loss greater than 5% in the last 6 months; individuals who have undergone cancer treatment less than 5 years ago, except for basal cell and squamous cell skin cancer	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-73x5yc	Effect of a Mother-oriented treatment and physiotherapy on the Mother&apos;s Anxiety, number of Gusts and Cry time in young and healthy babies	Recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1806	Effect of an intervention with Maternal Care guidelines and Manual Therapy on Maternal Anxiety, number of Regurgitations and time of Crying in young and healthy infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-73x5yc	<NULL>	Mothers over 18 years of age with full term newborns greater than or equal to 37 weeks of gestational age and less than 42 weeks of GI, healthy, with an Apgar score greater than 7 at the fifth minute, and with age-appropriate birth weight gestational	Mothers with impaired comprehension and verbal language will be excluded. It will be excluded newborns with Apgar less than seven in the fifth minute, malformation, neurological disease, congenital infection, and infants who throughout the study have a diagnosis of gastroesophageal reflux disease, with a history of aspiration, apnea, growth restriction , weight loss and difficulty in swallowing, allergy to cow&apos;s milk protein, in this study considered as presence of blood in the stool, inflammation of the anus, severe atopic dermatitis and use of formulas to treat food allergy; history of seizure and  or diagnosis of metabolic disease and use of medications such as domperidone, bromopride, metoclopramide, omeprazole and ranitidine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-33s6x5	Effect of a mouthwash containing Cinnamomum zeylanicum Blume (Cinnamon) for treatment of oral candidiasis	Data analysis completed	Intervention	2019-06-07	<NULL>	<NULL>	2731	"Clinical evaluation of a mouthwash based on Cinnamomum zeylanicum Blume (Cinnamon) on
Candida species in patients with denture stomatitis"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-33s6x5	<NULL>	Individuals aged 40 to 70 years with oral candidiasis and who wore removable dentures.	Individuals who had undergone topical and/or systemic antimicrobial treatment or were sensitive to C. zeylanicum EO or nystatin were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-4wdm8q9	Effect of a multimedia strategy for knowledge acquisition and reduction of caregivers of children and adolescents with cancer	Recruiting	Intervention	2022-03-22	<NULL>	<NULL>	5295	Multimedia Strategy for the acquisition of knowledge and reducing Anxiety of caregivers of children and adolescents in chemotherapy: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4wdm8q9	<NULL>	The inclusion criteria of the research are caregivers of both sexes, aged 18 years or over and who is the primary caregiver of the child or adolescent with cancer who will start chemotherapy	Exclusion criteria are caregivers of children and adolescents with cancer who have a disorder that makes them unable to understand and participate in the research; caregivers of children and adolescents who are starting chemotherapy treatment with disease recurrence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-463yhb3	Effect of a multimodal physiotherapy intervention to target balance capacity in Huntington s disease a double blind randomized clinical trial	Recruitment completed	Intervention	2022-08-01	<NULL>	<NULL>	5522	Effect of multimodal training with rhythmic cues in Huntington&apos;s Disease a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-463yhb3	<NULL>	Diagnosis of Huntington&apos;s Disease and confirmed by genetic test showing trinucleotide repeat number above 39; History of balance and gait impairments; and able to walk 10 minutes continuously and independently or with supervision indoors without walking aid	Mini-Mental Status Examination MMSE below 15 points; unstable medication over the past 3 months; and  hearing or visual problems interfering with the tests or training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-5r9pnrw	Effect of a muscle balance protocol on the knees of soccer players – a randomized controlled clinical trial	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8367	Evaluation of the effects of a muscular balance protocol on lower limbs of football athletes – a controlled clinical trial randomized	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-19	Universidade Federal de Alfenas	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5r9pnrw	<NULL>	Participants will be included, men between the ages of 13 and 20, football players from the city of Alfenas.	Participants under the age of 13 and over the age of 20 who are not soccer players will be excluded from these studies. Participants with a history of orthopedic injuries to the lower limbs in the last six months prior to screening will be excluded; presence of diseases and/or dysfunctions of any nature that interfere with the movements of the upper and/or lower limbs; dermatological lesions such as ulcers and blisters on the feet; individuals with infectious diseases, myopathies and recognized collagen disorders; those with neurological injuries and rheumatological diseases that affect the trunk; and those who do not wish to participate and do not agree to sign the ICF will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-8kgqk4	Effect of a muscle strengthening of the 1st dorsal interosseous in subjects with rhizarthrosis: a randomized controlled trial.	Not yet recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3605	Effect of a treatment protocol focusing on Muscle Strengthening of the 1st dorsal interosseous on aspects of activity and participation in subjects with Rhizarthrosis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8kgqk4	<NULL>	Volunteers with a medical diagnosis of rhizarthrosis; without cognitive impairment, taking into account a normal score on the Mini-Mental State Examination for the respective level of education.	Uncontrolled diabetes; neurological and/or musculoskeletal disorders that may affect upper limb function; fracture or previous surgical intervention on the wrist or fingers; the presence of any other rheumatologic disease; TMC joint infiltration within the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-10yqvvp6	Effect of a natural solution based on licuri oil on improving the cleaning and hygiene of complete dentures	Recruiting	Intervention	2025-08-20	<NULL>	<NULL>	8219	Efficacy of a licuri (Syagrus coronata) oil-based solution for biofilm control in complete dentures: a crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10yqvvp6	<NULL>	Adult patients; both genders; bimaxillary completely edentulous; users of complete dentures fabricated with heat-polymerized acrylic resin; in good general and oral health; intact and healthy mucosa without signs or symptoms of denture stomatitis; use of well-fitting dentures; availability to attend the clinic during intervention and data collection periods	Participants with hypersensitivity to sodium hypochlorite; smokers; history of untreated xerostomia or hyposalivation; participants with dentures installed less than 3 months ago; participants with broken, fractured, or relined dentures; participants lacking cognitive capacity to understand and follow the experimental protocol or respond to the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-7wvj2y	Effect of a new light and contrast mechanism on the detection of lesions in Endoscopic examination of the colon in Cancer screening procedures	Recruiting	Intervention	2020-09-10	<NULL>	<NULL>	4235	Effect of Linked Color Imaging on the detection of Adenomas in screening Colonoscopy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	carlos eduardo oliveira dos santos	Santa Casa de Caridade de Bagé	https://ensaiosclinicos.gov.br/rg/RBR-7wvj2y	<NULL>	both genders; age between 45 and 100 years; indication for colorectal cancer screening taking into account the guidelines of the American Cancer Society; adequate intestinal preparation; complete colonoscopy	symptomatic patients; age under 45 years; advanced colorectal cancer; use of antithrombotic medication; inflammatory bowel disease; previous colorectal surgery; presence of adenomas in previous colonoscopy that were not removed; acute lower gastrointestinal bleeding; inadequate bowel preparation; incomplete colonoscopy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-10zchcdk	Effect of a new peptide on weight control in obese people.	Recruitment completed	Intervention	2026-02-12	<NULL>	<NULL>	8865	Association between oral consumption of White Adipose Tissue Activator Cyclophilin A Peptide and body weight in obese individuals.	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Fundação do abc	<NULL>	<NULL>	<NULL>	Body mass index greater than or equal to 30.0 kilograms per square meter; age between 18 and 60 years; both sexes; glucose level at a maximum of 125 milligrams per deciliter	Patients with neoplasms; recent infections; chronic liver disease; diagnosed depression under treatment; chronic kidney disease; previous bariatric surgery; lung diseases including chronic obstructive pulmonary disease; recent cardiac event within the last six months; rheumatological diseases and other autoimmune diseases; excessive alcohol consumption; dementia; obesity associated with genetic syndromes; decompensated hypothyroidism; menopausal women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-5zgy25w	Effect of a non-drug intervention on pain and anxiety during influenza vaccination	Not yet recruiting	Intervention	2021-12-09	<NULL>	<NULL>	5094	Effect of a non-pharmacological intervention on pain and anxiety related to the administration of influenza vaccine in adults: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Departamento de Medicina e Enfermagem da Universidade Federal de Viçosa	Departamento de Medicina e Enfermagem da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5zgy25w	<NULL>	Age 18 years and over; both sexes; preserved cognition; be literate; receive only injection of the influenza vaccine via IM in the deltoid region	Participants reporting pain in the upper limbs; presence of injury or abrasions in the deltoid region; loss or alteration of sensation in the upper limbs, previous use of analgesics in the last six hours prior to immunization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-3ys6h4	"Effect of a nutritional education program on 
patients with  genetic high cholesterol  quality of life"	Recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2132	Effects of HIPERCOL program on patients with heterozygous Familial Hypercholesterolemia quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-19	Instituto Nacional de Cardiologia- INC	Instituto Nacional de Cardiologia- INC	https://ensaiosclinicos.gov.br/rg/RBR-3ys6h4	<NULL>	Patients with familial hypercholesterolemia genetic diagnosis performed by Brazilian`s Heart Institute (INCOR) e attending to cardiological treatment in National Institute of Cardiology-Brazil.	"Oral feeding difficulties;
clinical suspicion or diagnosis of hepatopathy and nephropathy in dialysis; oncological patients or patients undergoing gastroplasty; previous organ transplantation; wheelchair users; congestive heart failure; postoperative cardiac surgery (30 days); nutritional follow-up in the last 6 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-4bdbbbq	Effect of a Nutritional Intervention	Not yet recruiting	Intervention	2023-04-13	<NULL>	<NULL>	6004	Feeding Practices: the effect of a Nutritional Intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4bdbbbq	<NULL>	66 women; age between 20 to 59 years; BMI between 25 and 39.99Kg/m2; without prior nutritional monitoring; employees linked to the University of Passo Fundo; who accept and sign the Free and Informed Consent Form	women aged less than 20 years or over 60 years; BMI less than 24.99 kg/m2 or greater than 40 kg/m2; perform nutritional monitoring; participate in other intervention protocols; use weight loss medications; pregnant and lactating women; have a non-communicable chronic disease; use medication to any Chronic Noncommunicable Disease; having had previous bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-24m95ps	Effect of a Nutritional Program based on the degree of food processing on the metabolic control of individuals with Type 2 Diabetes Mellitus	Recruitment completed	Intervention	2023-11-24	<NULL>	<NULL>	6608	Evaluation of the Effectiveness of a Nutritional Intervention based on the degree of food processing for metabolic control of individuals with Type 2 Diabetes Mellitus assisted by primary health care in the state of Sergipe	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-15	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-24m95ps	<NULL>	Individuals with type 2 diabetes mellitus aged between 20 and 70 years, of both genders, assisted by Primary Health Care, from the Unified Health System (SUS) in the State of Sergipe, and who are users of the public health network residing in both urban and rural areas.	Individuals who are part of any group/study with an approach to food and nutritional education or other intervention, as well as pregnant women, patients using a feeding tube, patients who have undergone any surgical procedure in the last month, and patients with limiting factors for food intake due to their disease, such as head and neck cancer, HIV, and Chronic Obstructive Pulmonary Disease, will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-6xgzhpy	Effect of a period without and with smartphone use and continuous aerobic exercise on levels of anxiety and anger	Not yet recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6384	Comparison of the acute effect of a period without smartphone use with a period with smartphone use and continuous aerobic exercise on levels of state-anxiety and state-rage	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6xgzhpy	<NULL>	Age between 18 to 40 years; both genders; have your own cell phone with internet access	Contraindication for performing physical activity (PAR-Q); participants who are menstruating; pregnant participants; dysfunction (cardiac, endocrine, orthopedic and metabolic) that negatively influences the participants&apos; performance; anxiolytic treatment of any kind; and illiterate participants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-7dv562m	Effect of a Personalized Dietary Intervention on the Recovery of Children after Tonsillectomy and Adenoidectomy	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8960	Impact of a Personalized Dietary Intervention on the Recovery of Children After Adenotonsillectomy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-15	Centro Integrado de Saúde Amaury de Medeiros - CISAM/UPE	<NULL>	<NULL>	<NULL>	Children of both sexes; age between five and ten years; confirmed medical indication for adenotonsillectomy due to obstructive sleep apnea, recurrent upper airway infections or other conditions associated with hypertrophy of the tonsils and adenoids, including mouth breathing syndrome; nutritional status classified as eutrophic, mild undernutrition or overweight according to body mass index for age expressed as Z score; preserved functional capacity; respiratory function within normal parameters for age, except for alterations related to tonsil and adenoid hypertrophy; legal guardians committed to adherence to the intervention protocol and participation in follow-up assessments; written informed consent signed by legal guardians	Hemodynamic instability; presence of chronic respiratory diseases in exacerbation, including asthma, cystic fibrosis or chronic bronchitis; acute respiratory infection within thirty days prior to the intervention, including pneumonia or bronchiolitis; congenital or acquired heart diseases; metabolic disorders such as type one or type two diabetes mellitus and hypothyroidism; regular use of corticosteroids or continuous use of bronchodilator medication; severe undernutrition or morbid obesity; previous specific nutritional follow-up; occurrence of severe complications during or after adenotonsillectomy, including hemorrhage or severe infections; need for surgical reintervention or prolonged mechanical ventilation; absence of informed consent from legal guardians	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-26ydc3	Effect of a pharmacotherapeutic management protocol in patients hospitalized with cardiovascular diseases	recruiting	Intervention	2011-10-27	<NULL>	<NULL>	31	Improving Medication Adherence and Clinical Outcomes Following Hospitalization in Chronic Cardiovascular Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-07	Alfredo Dias de Oliveira Filho	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-26ydc3	<NULL>	"Aiming maximum inclusiveness we recruited all patients who had a discharge diagnosis
of CVD and who were on antihypertensive medication."	Patients were excluded if they reported already using any tool to improve their adherence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-969prp	Effect of a Pilates exercise program on flexibility, muscle performance and balance of elderly women.	recruiting	Intervention	2012-03-07	<NULL>	<NULL>	155	Effect of an exercise program based on the principles of the Pilates method in flexibility, muscle performance and balance of elderly women: a randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-31	Universidade Federal do Rio Grande do Norte (UFRN)	Universidade Federal do Rio Grande do Norte (UFRN)	https://ensaiosclinicos.gov.br/rg/RBR-969prp	<NULL>	Female; aged 65 to 80 years; absence of neurological and muscle - skeletal disease that preventing the holding of the exercises, as well as the use of a wheelchair for mobility; cognitive status compatible with schooling assessed by the Mini Mental State Examination (MMSE).	Refusal to participate in the survey; pain complaints during the course of training; unexcused absence and without replacement in 10% of training provided.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-4yht9x	Effect of a Planned Exercise Program on Physical Values and Quality of Life in Women with Breast Cancer Performing Neoadjuvant Chemotherapy	Not yet recruiting	Intervention	2019-05-23	<NULL>	<NULL>	2669	Effectiveness of a Structured Physical Exercise Oriented Program on Strength, Cardiorespiratory Fitness and Quality of Life in Women with Breast Cancer Submitted to Neoadjuvant Chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Departamento de Nutrição da Universidade Federal do Rio Grande do Norte - UFRN	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-4yht9x	<NULL>	Adult individuals; women; sedentary; age between 20 and 59 years; diagnosed with breast cancer; computed tomography scan of the abdominal region available on your chart; did not perform the first cycle of neoadjuvant chemotherapy.	Patients with metastatic disease; symptomatic cardiac or pulmonary disease; psychiatric; with intellectual physical incapacity to understand the stages of the research; in vulnerability to consent their participation or that do not obtain release of the oncologist to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-7w6pmpg	Effect of a plant-based diet on vascular health, cardiometabolic risk factors, body composition, and muscle function.	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9041	Effect of dietary monitoring based on a plant-based diet on vascular health, cardiometabolic risk factors, body composition, and muscle function.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal do Rio de Janeiro Campus Macaé	<NULL>	<NULL>	<NULL>	Adults: age between 18 and 59 years; both sexes; physically active (more than 150 minutes per week of physical activity). Older adults: age equal to or greater than 60 years; both sexes; eutrophic (body mass index between 22 and 27 kg/m²); physically active (more than 150 minutes per week of physical activity)	Adults: decompensated cardiovascular diseases; uncontrolled diabetes; pulmonary disease; smoking; urinary infection; pregnancy; lactation; use of medications that interfere with amino acid metabolism or nitric oxide production; use of antibiotics or anti-inflammatory drugs; use of nutritional supplements, multivitamins, or pharmacological agents. Older adults: diagnosis of severe decompensated cardiovascular disease; uncontrolled diabetes; pulmonary disease; smoking; urinary infection; use of medications that interfere with amino acid metabolism or nitric oxide production; use of antibiotics or anti-inflammatory drugs; use of nutritional supplements or pharmacological agents	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-6ynq8f	Effect of a potassium nitrate dentifrice on tooth sensitivity caused by in-office dental bleaching.	Not yet recruiting	Intervention	2020-05-14	<NULL>	<NULL>	3835	Comparative study on the use of toothpaste with 5% potasium nitrate before the whitening process	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	San Francisco of Quito University	San Francisco of Quito University	https://ensaiosclinicos.gov.br/rg/RBR-6ynq8f	<NULL>	This trial will include adults between 18 and 30 years old, regardless of gender, with good dental and periodontal health. Specifically attention will be given to six maxillary anterior teeth, which will be required to be caries-free and without buccal restorations. Shade of central incisors will be required to be A2 or darker in a value-oriented shade guide (VITA EasyShade Advance, Vita Zanhnfabrik).	This trial will exclude participants who have previously undergone tooth-bleaching procedures, dental sensitivity, pregnancy or lactation, and severe tooth pigmentation caused by drugs, fluorosis, or pulpal pathology. Participants will also be excluded if they are taking any form of medication (especially anti-inflammatory drugs), bruxism, enamel cracks, gingival recession, class V cavities, dentin exposure, or any other clinical condition that could cause dental sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-4bv89x8	Effect of a prenatal program on child development among babies exposed to Covid-19 in utero	Data analysis completed	Intervention	2024-09-21	<NULL>	<NULL>	7364	Exposure to SARS-Cov-2 and child development in the first year of life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-15	Instituto de Ensino e Pesquisa Alberto Santos Dumont	Universidade Estadual de Campinas -UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-4bv89x8	<NULL>	Inclusion criteria for both groups included singleton pregnancies followed at the Anita Garibaldi Health Center; minimum age 18 years; absence of confirmed or suspected fetal congenital infection or chromosomal anomalies; no serious illness or complications during pregnancy; and no substance use disorder	Failure to complete the follow-up during the first year after birth at the clinic; neonatal death; and extremely preterm (less than 28 weeks) or very preterm (less than 32 weeks) infants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-79dn4k	Effect of a program on drug use in patients with Ulcerative Colitis	Recruiting	Intervention	2020-01-02	<NULL>	<NULL>	3315	Impact of an intervention program on nonadherence to drugs in Ulcerative Colitis Patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade do Estado da Bahia	Programa de Pós-Graduação em Ciências Farmacêuticas - PPGFARMA	https://ensaiosclinicos.gov.br/rg/RBR-79dn4k	<NULL>	Patients diagnosed with ulcerative colitis (UC); at least 3 months of active registration in the Farmácia Integrada do Medicamento na Atenção Especializada(FIMAE); prescribed with at least 01 medicine to treat UC; of the same age or over 18 years; able to respond to the research tools; agrees to sign the Informed Consent Form (TCLE); assisted by outpatient clinics of Inflammatory Bowel Disease (IBD) at the Hospital Geral Roberto Santos(HGRS) or Hospital Universitário Professor Edgard Santos HUPES); owns a cell phone.	Patients classified as adherents.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8xm896	Effect of a propolis tablet on the saliva and the amount of adolescent dental plaque microbes comparing with the use of another tablet without propolis	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	4568	Effect of a propolis-containing tablet on the acidity of saliva and the amount of adolescent dental plaque microbes: a randomized clinical study comparing with the use of another tablet without propolis, and without knowing who will ingest and supply the tablet	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8xm896	<NULL>	Individuals aged 10-19 years; both genders; individuals without cavitary caries lesions; healthy individuals without any systemic diseases.	Individuals intolerant to some component of the propolis-containing tablet; subjects undergoing antimicrobial treatment during the course of the study or for a period of 30 days prior to the study; individuals who used products containing xylitol up to 30 days before the start of study or during the course of the study; individuals who used products containing propolis up to 30 days before the start of the study or during the course of the study; individuals with orthodontic appliances; individuals who are using oral mouthwashes during the period of study; individuals with a history of intraoral surgery within the last 6 months; individuals who are making use of products rich in polyphenols: coffee, mate, acai, in the previous period (30 days) and during the research; individuals who consume alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-82tzn4t	Effect of a respiratory physiotherapy technique in infants undergoing cardiac surgery	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9045	Effects of the Thoracoabdominal Rebalancing Method in infants undergoing cardiac surgery: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Ciências da Saúde do Trairí	<NULL>	<NULL>	<NULL>	Participants aged between 0 and 24 months; of both sexes; between 12 and 72 hours after cardiac surgical procedures performed via median sternotomy or percutaneous route (catheterization); Infants must present clinical stability that allows respiratory physiotherapy; whether in room air or using oxygen therapy (low or high flow)	Infants with chronic lung disease that compromises respiratory function such as bronchopulmonary dysplasia; those using positive pressure ventilation; those with congenital deformities of the rib cage or shoulder girdle; those who develop diaphragmatic paralysis postoperativel; present hemodynamic instability defined as persistent changes in heart rate or blood pressure outside the limits for age and arrhythmias of difficult control	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-7w6dh9q	Effect of a simulated environment on the knowledge and skills of health course students	Not yet recruiting	Intervention	2022-12-15	<NULL>	<NULL>	5765	Effectiveness of a simulated environment on the knowledge and skills of healthcare students	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Juiz de Fora	Faculdade de Enfermagem da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7w6dh9q	<NULL>	Students aged 18 or over. Students who have already taken the Fundamentals and Technologies of Nursing Care	Students who are not attending the course. Students who drop out. Students who do not fully participate in the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-2b8qtg	Effect of a single phototherapy session on lower limb muscle fatigue	Recruiting	Intervention	2019-10-03	<NULL>	<NULL>	3029	Single-session temporal effect of cluster phototherapy on lower limb muscle fatigue in sedentary young adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-2b8qtg	<NULL>	healthy; sedentary; volunteers	Neurological and cognitive impairment; cardiorespiratory diseases and history of joint and muscle injury in the last six months; muscle and joint injury; or absences during specific evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-5chrq5	Effect of a single session of physical exercise on blood markers in adult individuals with incomplete spinal cord injury	Data analysis completed	Intervention	2019-04-22	<NULL>	<NULL>	2625	Effect of a single session of gait training with body weight support on epigenetic parameters, brain derived neurotrophic factor levels and injury markers and peripheral blood muscle repair in adult individuals with incomplete spinal cord injury	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-16	Centro Universitário Metodista-IPA	Centro Universitário Metodista-IPA	https://ensaiosclinicos.gov.br/rg/RBR-5chrq5	<NULL>	For both groups, individuals with incomplete traumatic LM; aged between seventeen and fifty-five years old; of both genders and diagnosed for at least 6 months and at most 5 years of injury, will be included. For the trained groups, the subjects should be submitted to an intervention program (neurofunctional rehabilitation) for at least 6 months. For untrained groups, individuals should be performing only conventional physiotherapy.	As exclusion criteria, for both groups, all those with contraindications to weight support, such as individuals with hip fracture or lower limb or who present scabs, are included. Also, patients who present with unstable angina or other decompensated heart disease; chronic obstructive pulmonary disease; neurological diseases such as Parkinson&apos;s; stroke; who exhibit symptomatic drop in blood pressure when upright; who use medications with HDAC inhibitors valproic acid) and are undergoing active inflammation / infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-10j9738z	Effect of a sleep-facilitating dietary orientation in women undergoing breast cancer treatment	Recruiting	Intervention	2021-12-08	<NULL>	<NULL>	5089	Analysis of the effect of dietary guidance that facilitates sleep in women undergoing breast cancer treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10j9738z	<NULL>	Women undergoing chemotherapy; who do not have another type of cancer concomitantly	Women with intolerance to foods that facilitate sleep; who use a pacemaker; who present digital illiteracy; and those who do not accept or do not meet the inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-2sk64p	Effect of a small book on home care of preterm infants	Not yet recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1817	Effect of an educational technology on the home stimulation of preterm infants: clinical, non-randomized trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Escola de Enfermagem da Universidade de São Paulo	Hospital e Maternidade Rede D'OR São Luiz - Unidade Anália Franco	https://ensaiosclinicos.gov.br/rg/RBR-2sk64p	<NULL>	Family of children born with any level of prematurity who have been hospitalized in Neonatal Intensive Care Unit	Non-resident family members in the municipality of São Paulo	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-7jrxqm	Effect of a special nutritional oral supplement use on inflammation in patients with COVID-19	Recruiting	Intervention	2020-07-10	<NULL>	<NULL>	3997	Effect of oral supplement use with immunonutrients on inflammatory response in patients with COVID-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7jrxqm	<NULL>	Patients with the following criteria will be included: adults aged between 18 and 65 years, diagnosed with Covid-19 by molecular examination (RT-PCR), with pervious gastrointestinal tract, using oral diet and who are not on mechanical ventilation or requiring icu admission.	Pregnant patients; who have undergone the use of artificial nutrition in the 15 days prior to inclusion in this study; patients allergic to any components of the diets used; with severe hyperglycemia(greater than  180mg/dl) or hypertriglyceridemia (greater than  400mg/dl); with previous gastrointestinal diseases (surgical resections, malabsorption syndromes, inflammatory bowel diseases, persistent paralytic ileus, upper gastrointestinal bleeding or severe acute pancreatitis); with neutropenia-defined immunosuppression states, myelodysplastic syndromes, congenital immunodeficiency, or Acquired Immunodeficiency Syndrome (AIDS), immunosuppressive therapies in the last 03 months, systemic chemotherapy in the last 03 months, autologous bone marrow transplantation in the last year, halogenic bone marrow transplantation in the last 02 years, or existence of graft versus host disease (DEVH); with advanced chronic diseases (Child-Pugh stage C, grade IV heart failure (NYHA), chronic functional stage lung failure IV, terminal degenerative neurological processes, neoplasms in remission or progression over treatment); with processes with short life expectancy including end-stage chronic kidney disease; with acute processes that determine small survival as shock of any etiology with multiple organ dysfunction refractory to therapy in the first 48h or post-resuscitation severe neurological damage within 72 hours will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7cp49x	Effect of a Strength and Resistance Training protocol on Heart Variability in patients with kidney disease who are not on hemodialysis	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2046	Effectiveness of a Strengthening and Aerobic Training protocol on Heart Rate Variability in Predialytic patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7cp49x	<NULL>	Stages 4 and 5 non-dialysis chronic kidney disease patients; between 18 and 60 years old; from both sexes; using no medication that alters the autonomic nervous system	Patients in the following conditions will be excluded from this study those who participated in an intervention program less than three months ago; or presenting unstable arterial hypertension with diagnosed by a physician; amyloidosis; congestive heart failure; acute infarction; myocardial infarction (up to three months); unstable angina; osteoarticular abnormalities that make it impossible for them to execute the exercise protocols; peacemaker users and those who underwent heart transplantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5kcyrnq	Effect of a strength training program for abdominal muscles on performance in multidirectional jumps	Not yet recruiting	Intervention	2024-09-16	<NULL>	<NULL>	7345	Strength training for CORE muscles and performance in multidirectional jumps: implications for training and rehabilitation in sports	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Universidade Federal do Pampa - Campus Uruguaiana	Universidade Federal do Pampa - Campus Uruguaiana	https://ensaiosclinicos.gov.br/rg/RBR-5kcyrnq	<NULL>	Male and female; age between 18 and 35 years; recreational practice in sports involving jumping; who have not had delayed onset muscle pain and ligament or muscle injuries in the lower limb in the last 6 months	Body mass index greater than 30 kg/m²; musculoskeletal and/or vestibular problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-5ky68sc	Effect of a supplement combined with exercise on muscle loss and recovery in older adults	Recruiting	Intervention	2026-03-27	<NULL>	<NULL>	9026	Angiotensin-(1-7): its applications in the management of lean mass loss and muscle recovery	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Universidade Federal de Ouro Preto	<NULL>	<NULL>	<NULL>	older adults aged 65 years or older residing in the cities of ouro preto and mariana; presenting skeletal muscle loss; presenting any level of sarcopenia including severe sarcopenia; who agree to participate in the proposed intervention	participants who do not meet the inclusion criteria; who refuse to sign the informed consent form; who do not fully complete the research instruments; who do not demonstrate interest in participating in the intervention; individuals with severe liver disease; limiting cardiovascular disorders; severe renal impairment; dementia; parkinson disease; severe neuropsychological disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-10279hdr	"Effect of a technology on obstetric nurses&apos; knowledge about Stress prevention after trauma in pregnancy, labor and puerperium of women with physical disabilities: clinical trial
​"	Recruiting	Intervention	2024-03-14	<NULL>	<NULL>	6854	Effect of educational technology on obstetric nurses&apos; knowledge about post-traumatic Stress prevention in postpartum women with physical disabilities: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-26	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10279hdr	<NULL>	Specialist degree in Obstetrics, Women&apos;s Health or related; aged 18 or over; both genders; six months of experience in obstetrics; employed at the public maternity hospital selected for the study	In the process of retirement; on leave; termination of contract with the service; in administrative areas of the maternity; have more than one employment relationship between the public maternity hospitals participating in the study from the same government sphere	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-2cwy5d	Effect of a Therapy for discomfort in the musculature of the neck region in adults	Not yet recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1785	Effect of Radiofrequency in the contract of the  trapezius upper muscle in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-14	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2cwy5d	<NULL>	Adult patients between 18 and 40 years of age; pain and muscle contracture in the upper trapezius muscle	Subjects with altered sensitivity; intraorganic metal implants; osteosynthesis; electric implants; pregnant women; subjects on drug therapy for blood circulation (use of vasodilators or anticoagulants); hemophiliacs; subjects with outbreaks of infection and with fever; elitist neoplastic disease; in topical or non-muscle relaxation treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-36dr7t	Effect of a toothpaste containing fluorine, calcium and phosphate for the treatment of tooth sensitivity.	Not yet recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3069	Effect of a fluoride, calcium and phosphate dentifrice on the treatment of dentin hypersensitivity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Norte do Paraná - UNOPAR	Editora e Distribuidora Educacional S/A	https://ensaiosclinicos.gov.br/rg/RBR-36dr7t	<NULL>	Adult patients; age between 18 and 45 years; both genders; healthy; without systemic changes or continuous use of medications; having at least one tooth with an exposed root surface caused by abrasion, abrasion, erosion or gingival recession from which a painful response is elicited by a blast of air	PPatients with physiological changes; not classified as ASA I (pregnant women, patients with chronic diseases, patients with infectious foci in the oral cavity); teeth with evidence of pulpitis (tooth nerve pain), carious lesions, defective restorations, and active severe periodontal (gum) disease; use daily analgesic medication or any other medication that may mask painful symptoms; routinely use desensitizing toothpaste or any other desensitizing agent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-3j4d9ft	Effect of a toothpaste for sensitive teeth on the sensitivity and effectiveness of in-office dental bleaching	Recruitment completed	Intervention	2022-12-05	<NULL>	<NULL>	5755	Effect of a toothpaste for sensitive teeth and repair of enamel on the sensitivity and effectiveness of in-office dental bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-15	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-3j4d9ft	<NULL>	Patients over 18 years of age who sign an informed consent form.	Patients with caries, periodontal disease or changes in enamel; anterior maxillary teeth of color A1 or greater value; having restorations, endodontics, cracks or non-carious lesions in the anterior teeth; allergy to hydrogen peroxide.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-54px2gr	Effect of a Toothpaste with REFIX Technology on Tooth Sensitivity and Color Maintenance in the the treatment of darkned teeth	Recruiting	Intervention	2026-04-29	<NULL>	<NULL>	9151	Effect of a dentifrice with REFIX technology on tooth sensitivity and color maintenance after bleaching with 10% hydrogen peroxide: a triple-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-20	Universidade Federal da Paraíba	<NULL>	<NULL>	<NULL>	Volunteers aged 18 years or older. Good general and oral health condition, absence of carious lesions, gingivitis or periodontitis. Presence of six maxillary anterior teeth with shade A2 or darker according to the Vita Classical shade guide	Previous history of dental bleaching treatment. Pre-existing dentin hypersensitivity. Presence of dental prostheses or orthodontic appliances. Restorations in the maxillary anterior teeth. Presence of non-carious cervical lesions. Endodontic treatment in the maxillary anterior teeth. Teeth with tetracycline staining or dental fluorosis. Visible enamel cracks. Parafunctional habits such as bruxism or smoking. Pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-8q65vps	Effect of a treatment for upper limb and language in post-stroke patients	Recruiting	Intervention	2022-05-31	<NULL>	<NULL>	5412	Relationship between motor skill and language post-stroke and use of neuromodulation associated with peripheral therapies to improve movement, manual function and language	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-20	Universidade Federal de Sergipe	Programa de Pós-graduação em ciências aplicadas à Saúde (PPGCAS)	https://ensaiosclinicos.gov.br/rg/RBR-8q65vps	<NULL>	Patients aged between 30 and 80 years will be included; of both sexes, diagnosis of ischemic or hemorrhagic stroke confirmed by computed tomography or magnetic resonance imaging, absence of cognitive deficits (assessed by the MMSE - Mini Mental State Examination, score greater than 18 ; All degrees of motor impairment according to the classification Fugl-Meyer score (total score 0 to 66 points): severe (Fugl-Meyer score 0 to 15 points), severe or moderate (16 to 34 Fugl-Meyer points), moderate/mild (35-53 Fugl points -Meyer) and mild (54 to 66 Fugl Meyer points); Aphasic patients will be evaluated by the Boston Naming Test and Montreal-Toulouse Battery Test (MTL-Brazil), in all degrees of impairment: alert for neuropsychological deficit (- 1.0 and -1.5), moderate to severe deficit (-1.6 and -2.0), presence of very severe deficit (less than or equal to -2.0), does not suggest cognitive deficit (greater than - 1.0)	Patients who present the following conditions will be excluded: clinical evidence of multiple brain lesions or other associated neurological diseases; peripheral neuropathies, leprosy, fibromyalgia, rheumatoid arthritis; other upper and lower motor neuron pathologies; history of psychiatric illness including drug and alcohol abuse; orthopedic deformities installed in the upper limbs. Those who are undergoing rehabilitation treatment during the collection (Occupational Physiotherapy and/or Speech Therapy) will not participate in the research. Patients with receptive types of aphasia (assessed by the MTL-Brazil test) will also be excluded. In addition to these, due to contraindication for the application of tDCS, patients with intracranial metallic implants will be excluded; pregnancy; use of medication that interferes with cortical excitability; history of seizures and/or epilepsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-4kdqcbt	Effect of a two-task exercise in Virtual Reality on the physical and mental point of view in the elderly: a randomized clinical trial	Not yet recruiting	Intervention	2022-03-08	<NULL>	<NULL>	5263	Effect of a Dual Task training in Virtual Reality on physical-functional and cognitive aspects in the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Centro de Estudos Superiores de Maceió - CESMAC	Centro de Estudos Superiores de Maceió - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-4kdqcbt	<NULL>	Seniors; Age between 60 and 79 years; both sexes; with cognitive modifications on the Mini Mental State Examination (MMSE)	Inability to understand simple verbal commands; severe visual impairment or not compensated with the use of corrective lenses; serious auditory implications; who have completed any cognitive training program in the past six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-5cf7vzj	Effect of a vaginal gel on menopausal women with breast cancer	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7265	Evaluation of the effectiveness of a non-hormonal vaginal moisturizer gel on vaginal and sexual health in postmenopausal women with breast cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-05	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Hospital das Clínicas da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5cf7vzj	<NULL>	Women; date of last menstruation at least 12 months ago;  age between 45 and 65 years old; histological diagnosis of breast cancer; completed cancer treatment; except adjuvant endocrine therapy; stage I, II and III;  sexually active;  presence of vaginal symptoms of menopausal geniturinary sindrome; ability to understand and consent to your participation in the study	Stage IV and or metastatic disease will be excluded;  current radiotherapy or chemotherapy; alcoholic or drug addicts;  current use of vaginal moisturizers;  use of vaginal estrogen in the previous six months;  infection of the lower genital tract; cognitive deficit; illiteracy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-6jm5zht	Effect of a vein illuminator device on the success of peripheral venipuncture in adults with difficult access: randomized controlled trial	Recruitment completed	Intervention	2024-03-07	<NULL>	<NULL>	7210	Accuvein® effectiveness in successful peripheral intravenous catheterization in adults with Difficult Access: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-08	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6jm5zht	<NULL>	Patient aged 18 years or over. Both genders. Patient who has one of the following characteristics: having undergone two or more attempts at peripheral intravenous access using traditional techniques, having a physical examination suggestive of difficult intravenous access (for example, absence of visible or palpable veins) or having a declared condition or documented history difficult intravenous access.  Be subjected to Peripheral Intravenous Catheterization - PIC on an elective basis, during the day. Peripheral Intravenous Catheterization – CIP for the purpose of administering intravenous solutions or medications. Patients who do not show signs of clinical deterioration immediately before or during the procedure (NEWS-2 Score)	Patients who for some reason give up participating in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:07
RBR-5mnpmzc	Effect of a virtual exercise program on the health of women who have undergone breast Cancer	Recruiting	Intervention	2026-01-14	<NULL>	<NULL>	8754	Effect of a multicomponent physical conditioning telehealth program and an app providing guidance on a more active lifestyle on health outcomes in women who have survived breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Escola de Educação Física e Esporte da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Female sex; having completed oncological treatment within the interval of six months to five years; having received clearance from the oncology hospital healthcare team to engage in physical activity and/or exercise; being aged 40 to 69 years; not presenting metastatic disease, severe lymphedema, or other uncontrolled chronic diseases or conditions; having access to a mobile phone or computer with a camera; having access to the internet; agreeing to participate in the intervention involving a three-month virtual multicomponent physical teleconditioning program	To withdraw from continued participation in this study; to report cancer recurrence or any adverse event that poses a risk to health	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-26b5dtq	Effect of a2 milk, biofortified or not, on the diet of children with Autism Spectrum Disorder	Recruitment completed	Intervention	2023-08-31	<NULL>	<NULL>	6401	Effect of milk biofortified with selenium and vitamin e from cows with genotype a2a2 in the diet of children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-03	Faculdade de Zootecnia e Engenharia de Alimentos da Universidade de São Paulo	Fonterra Co-operative Group Ltd	https://ensaiosclinicos.gov.br/rg/RBR-26b5dtq	<NULL>	Child aged 3 to 10 years; male and female gender; diagnosis of Autism Spectrum Disorder (ASD) according to the evaluation criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); being classified into one of the three grades of autism	Positive diagnosis for cow’s milk protein allergy. Use of antibiotics or in the last 7 days prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-7rg7479	Effect of abdominal Elastic Tape after Cesarian Section	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7264	Effect of abdominal taping after cesarian section	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-12	Fundação Educacional Lucas Machado FELUMA	Hospital Mater Dei- Betim/Contagem (HMD-BC)	https://ensaiosclinicos.gov.br/rg/RBR-7rg7479	<NULL>	Postpartum women over 18 years of age with up to 48 hours post-cesarean section; no indwelling bladder catheter; adults hospitalized for obstetric care at the Maternity Hospital of the MaterDei-Betim Hospital/Contagem HMD-BC	Skin diseases or active wounds in the abdominal region; height of the fundus of the uterus above the umbilical line; hemorrhages; laparotomic or other open abdominal surgeries, excluding previous cesarean sections; not literate; not understanding the researchers’ instructions; refuse to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-3g7q8bx	Effect of Abdominal Exercises on scapular positioning and shoulder performance in people with Shoulder Pain and Altered Scapulae	Recruiting	Intervention	2021-12-02	<NULL>	<NULL>	5065	Effect of different strategies Periescapular Muscles Resistance Training  associated with Core Training on pain, function and performance of subjects with Shoulder Impact Syndrome and Scapular Dyskinesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de Pernambuco	UNIVERSIDADE DE PERNAMBUCO	https://ensaiosclinicos.gov.br/rg/RBR-3g7q8bx	<NULL>	Both sexes; have a medical or physiotherapeutic diagnosis of subacromial pain; positivity in specific orthopedic tests (Neer, Hawkins-Kennedy, Jobe and painful arch); be physically independent.	Present clinical conditions or unstable disease that contraindicates the practice of supervised physical exercise; present range of motion of arm flexion less than 120°; have a history of trauma or surgery on the shoulder; have severe deformities in the thoracic spine (scoliosis or hyperkyphosis); be positive for clinical tests of glenohumeral instability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-104qh4qd	Effect of Abdominal Massage in People with Anxiety and Stress	Data analysis completed	Intervention	2024-09-12	<NULL>	<NULL>	7338	Effect of Visceral Mobilization in patients with Anxiety and Stress Symptoms: a double-blind, randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-16	Colégio Brasileiro de Osteopatia	Universidade de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-104qh4qd	<NULL>	Self-reported symptoms of anxiety and/or stress; age between 18 and 60 years; regardless of sex	Presence of incision or tumor in the abdominal region; presence of fractures, rheumatic pathologies or infection in the acute phase; impossibility of understanding the proposed assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-9b78kj	Effect of Acai consumption on variables related to muscle damage induced by exercise in active individuals.	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3871	Effect of consumption of Acai (Euterpe oleracea Mart.) on late pain, recovery and exercise-induced muscle damage: clinical, randomized, crossover, double-masked, and controlled placebo study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9b78kj	<NULL>	Age between 18 and 50 years; practice physical exercise for at least six months; and be available to participate in the study.	present intolerance / aversion to açaí; use alternative treatments to reduce late pain (acupuncture, cryotherapy, anti-inflammatory drugs, analgesics, among others); you are a smoker; present a weight change greater than 10% in the last three months; have chronic (cardiovascular, renal, liver, intestinal), infectious, inflammatory or acute illnesses that have required treatment in the past two months; having had cancer in the past ten years; chronic use of medication, except contraceptives; make use of anabolic steroids; use nutritional supplements, except supplements based on carbohydrates and proteins; is in gestational or breastfeeding period; has undergone surgical intervention to treat obesity; and is not available to participate in the meetings regarding the intervention and data collection of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-86yjpg	Effect of açaí-juçara pulp consumption on inflammation of overweight adults	Recruitment completed	Intervention	2019-09-17	<NULL>	<NULL>	2960	Effect of juçara pulp (Euterpe edulis Martius) in epigenetic modifications and inflammatory status in monocytes of obese adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Federal de São Paulo - UNIFESP campus Baixada Santista	Universidade Federal de São Paulo - UNIFESP campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-86yjpg	<NULL>	The study included volunteers with obesity (BMI between 30.0 and 39.9 kg / m2) with insufficiently active lifestyle, male and female, aged 31 to 59 years, according to the classification of the adult phase of the Organization World Health Organization (WHO, 2005).	Body mass index (BMI) below 29.9 kg/m2 or above 40.00 kg/m2; Infectious diseases and/or severe chronic diseases; Using medications that interfere with the inflammatory cascade, lipid metabolism and food consumption, such as statins, aspirins, hormones and/or antidepressants; Abuse of alcohol and drugs; - Pregnancy; Menopause.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-10k58ztj	Effect of acid conditioning in the treatment of periodontal bone defects	Recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8195	Effect of superficial bone demineralization by citric acid and tetracycline on the repair of infra-bone defects. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade de São Paulo, Faculdade de Odontologia de Bauru	Universidade de São Paulo, Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-10k58ztj	<NULL>	Age 35 - 60 years; radiographic evidence of at least one infrabony 2 or 3-wall or combined interproximal periodontal defect; attachment loss ≥ 5 mm	Systemic disorders (uncontrolled diabetes and hypertension, hemophilia or other coagulation disordes); pregnants or lactants; systemic therapy with antimicrobials, antineoplastics, anticoagulants, immunostimulants or immunodepressors 4 weeks before study beggining; radiotherapy and/or immunosupression; endodontic lesions; grade 2 tooth mobility; severe parafunction; allergy to citric acid and/or tetracycline; illicit drugs or alcohol abusers; smokers or former smokers &lt; 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-4d93q84	Effect of active storytelling methodology on learning about the Unified Health System	Not yet recruiting	Intervention	2022-04-19	<NULL>	<NULL>	5351	Effect of storytelling on learning about the history and institutionalization of the Unified Health System: a randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4d93q84	<NULL>	students regularly enrolled in the 2nd period of the course; older than 18 years.	students expected to leave for the next 15 days; students who have already participated in the previous assessment of the instrument (in any of the previous stages of the study); not completing the data collection instrument completely; non-participation in the second application of the post-test that will occur on the 15th day after the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-5fm97x	Effect of active video games on students during physical education classes in school	Recruiting	Intervention	2019-10-25	<NULL>	<NULL>	3134	Effect of exergames practice on children and adolescents during physical education classes in school	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-5fm97x	<NULL>	Participation of students invited to compose the project sample will be voluntary; Inclusion criteria are no health limitations that prevent participation in exercise evaluations or protocols; Students included to participate in the study should be in the elementary or high school classes, and should be between the ages of 07 to 18 years; be able to participate regularly in the physical education classes proposed by the school.	Exclusion criteria for the research participant are: withdrawal request by the participant or guardian; presentation of some physical limitation that makes the practice of exergames impossible; attend less than 75% of classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-8w9dbt	Effect of Acupuncture before Wisdom tooth extraction that is not yet born	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1839	Effect of Energetic Regulation with Acupuncture in molar third-party exodontia surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-23	Faculdade de Odontologia da Universidade Estadual de Campinas	Faculdade de Odontologia da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8w9dbt	<NULL>	Volunteers both genres; age between 18 and 30 years; with good general health; with four third molar teeth being the two lower molars included or semi-included with the same anatomical position	Volunteers with lower molars in antagonistic anatomical positions; weakened general health; clinical history of previous infection; carriers of severe emotional disorders; The energy level balanced between the normal range of 40 to 60	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-77y2sp	Effect of acupuncture in the articulation of the jaw and in the energetic balance of the meridians	Recruitment completed	Intervention	2017-05-11	<NULL>	<NULL>	1229	Effect of acupuncture in temporomandibular disorders and energy balance of meridians	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-22	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-77y2sp	<NULL>	Adult volunteers; of both genders; age between 20 and 50 years; with pain due to temporomandibular dysfunction of muscular or mixed origin; with or without mouth opening limitation.	Volunteers with severe trauma or infections in the Temporomandibular Joint; under analgesic and/or anti-inflammatory drugs; pregnant women; fear of needle; under some other type of treatment for temporomandibular joint; edentulous; volunteers using dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-59f4yr	Effect of acupuncture on anxiety in infertility women	data analysis completed	Intervention	2012-01-04	<NULL>	<NULL>	52	Effect of acupuncture on anxiety in women undergoing to in vitro fertilization	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-04-01	Serviço de Reprodução Humana - Faculdade de Medicina do ABC	Serviço de Reprodução Humana - Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-59f4yr	<NULL>	Women newer than 45 years, without previous psychiatric disorders, without use of antidepressants and / or anxiolytics and without use of acupuncture before.	Women older than 45 years, previous psychiatric disorders, use of antidepressants and / or anxiolytics and use of acupuncture before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-9stskc6	Effect of Acupuncture on anxious symptoms of healthcare students with Generalized anxiety disorder: randomized controlled clinical trial	Not yet recruiting	Intervention	2024-12-04	<NULL>	<NULL>	7565	Effect of Acupuncture on anxious symptoms in healthcare students: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Instituto de Patologia Tropical e Saúde Pública da Universidade Federal de Goiás	Instituto de Patologia Tropical e Saúde Pública da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9stskc6	<NULL>	Students with symptoms of generalized anxiety even with conventional treatment (Generalized Anxiety Disorder Scale greater than 10); previous diagnosis by a psychiatrist according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders for generalized anxiety disorder; and students in the health area, regularly enrolled in the educational institution; over 18 years old; both sexes	Current psychosis and psychosis in the last 6 months; substance dependence in the last 6 months; severe depression that is significantly more relevant than generalized anxiety disorder; pregnancy or postpartum women; having undergone acupuncture treatment in the last 30 days; intolerance to acupuncture (needle phobia); students who are taking the subject of Acupuncture and Medical Homeopathy, and students who have completed less than 1 year of graduation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-833mm2	Effect of acupuncture on fibromyalgia	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3534	Effect of systemic acupuncture associated or not with ear acupuncture in subjects with fibromyalgia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Andreia Maria Silva Vilela Terra	Andreia Maria Silva Vilela Terra	https://ensaiosclinicos.gov.br/rg/RBR-833mm2	<NULL>	Women; age between 40 and 60 years; diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology (ACR 10)	Individuals with needle phobia; with hemorrhagic diatheses; pregnant or lactating women; individuals who are being treated with massage or acupuncture in the last two weeks before the intervention; or anesthetic drugs, analgesics, muscle relaxants or anti-inflammatory drugs in the last two days before the intervention; who have other associated pathologies and people with metallic implants; Tattoo; birthmarks; alteration of pigmentation at the site of the application of acupuncture points; I inserted olive oil with a lot of intensity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-7bwj6r	Effect of Acupuncture on Leukopenia and Language Appearance in Women with Breast Cancer during Chemotherapy: Randomized Clinical Trial	Recruiting	Intervention	2019-09-26	<NULL>	<NULL>	3124	Effect of Acupuncture on the Mononuclear Fraction of Peripheral Blood and Language Aspect in Women with Breast Cancer During Chemotherapy: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-28	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7bwj6r	<NULL>	Breast cancer diagnosis; adjuvant and neoadjuvant treatment with anthracyclics and minimum age of 18 years.	Previous history of leukopenia; metastatic disease; other cancers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-6hvjnq	Effect of acupuncture on pain and inflammatory mediators in patients with fibromyalgia	Recruiting	Intervention	2018-03-01	<NULL>	<NULL>	1669	Fibromyalgia: studies involving pathophysiological mechanisms associated with pain, inflammation and muscle damage and the potential effect of acupuncture on these processes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Santa Maria/Pro-Reitoria de Pós-Graduação	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6hvjnq	<NULL>	"Women;
Age between 20 and 60 years old;
Diagnosis of fibromyalgia according to the American College of Rheumatology criteria."	"Severe psychiatric illness;
With neurological or sensory deficit;
Patients who have contraindications to acupuncture;
Pregnant women;
Lactating;
Patients unable to attend the acupuncture sessions;
Patients who do not accept the conditions proposed in the term of free and informed consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-3m45y3	Effect of Acupuncture to control Diabetes.	Recruitment completed	Intervention	2018-06-04	<NULL>	<NULL>	1867	A randomized controlled trial evaluating the effect of acupuncture on type 2 diabetes using the FreeStyle libre® system.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Instituto de Ciências Farmacêuticas	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-3m45y3	<NULL>	Research participants should be able to clearly understand and cooperate with all the procedures described in the Study Consent Form, including completing the questionnaires. Men and women between the ages of 20 and 75; Patients with type 2 diabetes for at least 3 years with stable glycemic control; verified by the A1c dosage in the last 3 months without change of medication.	"Use of synthetic glucocorticoids * such as prednisone, prednisolone, methylprednisolone and hydrocortisone by oral or topical routes.
Pregnancy; Type 1 Diabetes; Antecedents or suspected nephrotic syndrome, hepatic insufficiency, hyperthyroidism, acromegaly, renal failure; Use of insulin to treat diabetes"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-2fkzb2s	Effect of acupuncture with electrical stimuli and therapy with games in elderly with knee arthrosis	Data analysis completed	Intervention	2022-07-12	<NULL>	<NULL>	5481	Effect of Electroacupuncture and Wii therapy on functional performance and inflammatory parameters in elderly with knee osteoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-08	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2fkzb2s	<NULL>	Be 60 years of age or older;Have a diagnosis of osteoarthritis in at least one knee, based on the American College of Rheumatology clinical and radiographic criteria (Hinton, et al. 2002); with classification II, III or IV in the classification grades of Kelgreen and Lawrence (Kelgreen &amp; Lawrence, 1657);Have symptoms for knee osteoarthritis with scores equal to or greater than two on the visual analogue pain scale (VAS);Not having undergone any surgical procedure on the lower limbs;Not having had recent trauma to the knees;Not having undergone physical therapy treatment or any other rehabilitation procedure in the last three months;Present minimal clinical and cognitive conditions to perform physical activities;Not using glucocorticoids for at least two months.	Elderly people with knee or hip arthroplasty; Acute orthopedic, neurological, respiratory or cardiac diseases that prevent them from performing the proposed exercise; Cognitive deficit suggested by a lower score than those compatible with their education when performing the Mini Mental State Examination (for illiterate people the score is 13; for schooling between one to three years, 18; for schooling between four to seven years, 23; for schooling over seven years, 26) (BERTOLUCCI et al., 1994); Vestibular disorders; Immunosuppressed or immunodeficient .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-69ynnw	Effect of acupuncture with needles on the physical and psychological and emotional aspects of patients with problems in the articulation of the jaw.	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1760	Effect of Auriculotherapy on the physical and psycho-emotional aspects of patients with myofascial temporomandibular disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-04	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-69ynnw	<NULL>	Adult volunteers aged 18 years or over; score equal to or greater than 3 in the Triage Questionnaire of the American Academy of Orofacial Pain; with the presence of myofascial pain according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC / TMD).	Volunteers with non-painful temporomandibular disorder according to RDC / TMD; patients with associated diseases: fibromyalgia, facial paralysis, rheumatoid arthritis, mental illness or cognitive deficits that would impede the understanding of some of the stages of the research; pregnant women; with external ear injuries or with immunodepression; carriers of clotting disorders, metabolic, vascular or neoplastic diseases; volunteers submitted to other types of associated therapies - interocclusal apparatus, psychotherapy, physiotherapy, orthodontics, alternative therapies; volunteers who use continuous medication (analgesics, anti-inflammatories, muscle relaxants, antidepressants / anxiolytics, anticonvulsants).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9n9yq4p	Effect of acute caffeine intake on rating of perceived exertion, muscle pain and fatigue during exercise in women with fibromyalgia	Not yet recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5175	Effect of acute caffeine intake on perceptive responses, muscle oxygenation and neuromuscular fatigue development during exercise in women with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9n9yq4p	<NULL>	Volunteers with an age between 30 and 60 years; be classified as sedentary or insufficiently active according to the  international physical activity questionnaire; clinical diagnosis of fibromyalgia according to the American College of Rheumatology criteria	tobacco usage; any kind of bone or muscle injury that prevent to perform the exercise tests; any restriction related to caffeine intake or physical exercise practice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-928hcw	Effect of acute consumption of green tea (Camellia sinensis) on energy metabolism, satiety sensation and food intake	Recruitment completed	Intervention	2020-04-29	<NULL>	<NULL>	3790	"Effect of allegedly thermogenic tea intake on metabolism energy, feeling full and food intake of individuals with excess of
Weight"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-29	Universidade Federal de Minas Gerais	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-928hcw	<NULL>	Will be included in this study individuals with stable weight; non smokers; who do not use dietary supplements or medications except oral contraceptive; that may interfere with the study results.	Diabetics; hypertensives; carriers of diseases that interfere with energy metabolism; allergic or sensitive to any of the standard breakfast ingredients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-7n496r	Effect of acute consumption of juçara juice in damage indicators caused by free radicals and inflammation before and after exercise and the relation with depressive symptoms and anxiety	Data analysis completed	Intervention	2019-03-15	<NULL>	<NULL>	2525	Effect of acute consumption of juçara juice (Euterpe edulis Martius) in oxidative stress biomarkers and inflammatory profile before and after a high-intensity interval exercise session and the relation with depressive symptoms and anxiety: a randomized single-blind cross-over trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-7n496r	<NULL>	Male; age between 19 and 30 years; and physically active	Sedentary individuals; smokers; carriers of any diseases, visible or known inflammatory or infectious processes; muscleskeletal injuries in the last 3 months; users of vitamin and mineral supplements, ergogenic resources (carnitine, arginine, creatine and caffeine), anabolic steroids or medications in the month prior to the interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5ftg3z	Effect of acute ingestion of cinnamon (Cinnamomum zeylanicum) tea on energy metabolism, satiety sensation and food intake	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3763	"Effect of allegedly thermogenic tea intake on metabolism
energy, feeling full and food intake of individuals with excess of
Weight"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-29	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5ftg3z	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 40 years; with stable weight; who do not use dietary supplements or medications that may interfere with the results of the study	Hypertensive; diabetic; carriers of diseases that affect energy metabolism; allergic or sensitive to standard breakfast ingredients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7f8rdnf	Effect of acute theacrine supplementation and exercise on mood, cognition, and health in young adults.	Recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8085	Evaluation of the effect of acute theacrine supplementation associated with a physical exercise program on mood, mental health, cognition, and health parameters of young individuals.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-09	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-7f8rdnf	<NULL>	Adults aged between 18 and 45 years; individuals engaged in resistance training for at least six months prior to the first study visit, to avoid delayed-onset muscle soreness typically observed in untrained individuals; with or without a diagnosis of common mental disorders (anxiety and/or depression); of both sexes	Osteoarthritis and rheumatoid arthritis; human immunodeficiency virus (HIV) infection; musculoskeletal disorders that prevent physical exercise; hypertension (systolic blood pressure above 120 mmHg and/or diastolic blood pressure above 80 mmHg); cardiovascular diseases; pregnancy and lactation; use of anticonvulsants; use of central nervous system stimulants, such as methylphenidate (Ritalin®, Concerta®), lisdexamfetamine (Vyvanse®, Juvene®), bupropion hydrochloride (Wellbutrin XL®, Zetron XL®, Bup), lithium carbonate (Carbolithium®); smokers, due to the stimulant effect of nicotine on the central nervous system. All information will be collected through anamnesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-5y5pbpr	Effect of acute use of Melatonin on Hemodynamic, Metabolic and Physical Variables during and after Running exercise in different conditions	Not yet recruiting	Intervention	2024-06-03	<NULL>	<NULL>	7044	Effect of acute Melatonin administration on Physiological and Physical Performance Parameters during and after Running in different conditions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de São Carlos - UFSCar	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-5y5pbpr	<NULL>	Men and women aged between 18 and 35; apparently healthy; physically independent; normotensive; non-obese (i.e., Body Mass Index greater than 30 kilograms per square meter and body fat percentage less than 20 percent; not tobacco or alcohol users; moderately active (i.e., greater than or equal to 150 minutes per week of physical activity ); engaged in regular physical training programs.	Subjects who self-report cardiovascular, metabolic diseases, sleep and neuromuscular disorders and/or musculoskeletal injuries; continuous use of dermatological medications and antipyretics and diuretics; have used ergogenic substances (e.g., anabolic androgenic steroids) in the last six months prior to the start of research; skin folds in the regions of interest (front of the thigh and arm) greater than 20 millimeters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-8k98md3	Effect of adding Self-Efficacy Strategies to Strengthening Exercises and Manual Therapy on functionality and self-efficacy of patients with shoulder pain: a randomized controlled trial with economic evaluation	Recruitment completed	Intervention	2023-01-18	<NULL>	<NULL>	8200	Efficacy of adding Self-Efficacy Strategies to Strengthening Exercises and Manual Therapy for disability and self-efficacy of individuals with chronic shoulder pain: a randomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8k98md3	<NULL>	Individuals who have one of the following diagnostic terms “Anterior shoulder pain”; “Subacromial Impingement Syndrome”; “Subacromial Impingement Syndrome”; “Painful shoulder”; “Shoulder Tendinitis” or specific rotator cuff tendonitis; “Subacromial bursitis” or “Subdeltoid bursitis” in the diagnostic field; Both sexes; Age from 18 years old; Shoulder pain for more than 12 weeks; 3 or more positive findings in the “Painful arch in flexion or abduction” tests; “Neer”; “Hawkins-Kennedy Test”; “pain on resisted external humeral rotation” or “Jobe&apos;s Test”	Previous history of shoulder surgery or injuries caused by external forces; full-thickness tear of the rotator cuff as evidenced by imaging (US or MRI); shoulder instability; adhesive capsulitis; or if they are involved in cognitive-behavioral and cognitive-functional therapy due to conflicting literature on possible changes in self-efficacy in this population; Cardiovascular and neurological disorders including cervical and arm nerve entrapment syndromes; pregnant women; those who are unable to perform the required clinical assessment tasks, answer the questionnaires, or attend the required assessment and intervention sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-9p5yqr9	Effect of additional consumption of juçara pulp on weight, body fat and quality of life in post-treatment Breast Cancer patients	Recruiting	Intervention	2023-04-25	<NULL>	<NULL>	6033	Impact of juçara (Euterpe edulis Mart.) supplementation on lipid profile, body composition and quality of life in post-treatment Breast Cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-27	Faculdade de Nutrição da Universidade Federal de Goiás	Hospital de Câncer Araújo Jorge	https://ensaiosclinicos.gov.br/rg/RBR-9p5yqr9	<NULL>	Patients undergoing oncological follow-up for up to 5 years after the last treatment performed, who were diagnosed with triple-negative breast cancer in Stages I to III; attended at the Mastology and Gynecology outpatient clinic of the hospital; age ≥ 18 years; women; is not receiving a nutritional supplement; be able to sign the TCLE; who is on an exclusive oral diet	Participants using anti-inflammatory drugs; patients diagnosed with Diabetes Melittus type I and II; post-treatment patients with other types of cancer; cognitive and/or walking disability; with a closed diagnosis of metastasis; feeding that is not exclusively oral; absorptive dysfunctions (Crohn&apos;s, ulcerative colitis, short bowel syndrome); autoimmune diseases; liver diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-3bf686	Effect of adhesive strategy and different photoactivation times of a universal adhesive system on the longevity of composite resin restorations in patients with dental lesions near the gingiva.	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2709	Effect of adhesive strategy and different photoactivation protocols of a universal adhesive system on the longevity of composite resin restorations in patients with non-carious cervical lesions [LCNC] . Double-blind randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-20	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3bf686	<NULL>	Patients older than 18 years will be included; Presence of at least two LCNC per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-9bwgr9	Effect of adhesive usage in complete denture wearers	recruitment completed	Intervention	2012-11-30	<NULL>	<NULL>	102	Effect of using an adhesive in conventional complete denture wearers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-10	Universidade Estadual Paulista Júlio de Mesquita Filho	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9bwgr9	<NULL>	Adults; mentally agile and responsive; with resilience and alveolar volume normal; absence of dysfunctions in the stomatognathic system and the absence of debilitating systemic changes	Debilitating neurological or systemic diseases and the need for pre-prosthetic surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-2hz3tg	Effect of administration  beneficial bacteria on the health in overweight women	Data analysis completed	Intervention	2015-06-10	<NULL>	<NULL>	2141	Effect of administration of probiotics on inflammatory markers in overweight women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2hz3tg	<NULL>	body mass index between 25 and 39.9 kg/m2; aged between 20 and 64 years; who receive outpatient care in general nutrition and nutrition in endocrinology hospital of the University Federal of Goiás	Do not perform all evaluations; Participate in a program of food restriction; Body mass index less than 25 kg/m2 or 40 kg/m2; Patients with immune diseases or immunosuppressive drugs; Patients with liver or kidney disease; chronic alcoholics; In using nutritional supplements;  Pregnant women; In insulin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-10vnmdb7	Effect of Aerobic and Isometric Physical Exercise with handgrip on blood pressure in people with Medication-Resistant Hypertension	Recruiting	Intervention	2025-09-30	<NULL>	<NULL>	8332	Effect of Aerobic and Isometric Physical Exercise with Handgrip on Blood Pressure in Resistant Hypertensive Individuals: Evaluation of Autonomic and Hemodynamic Mechanisms	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-08	Instituto de Educação Superior da Paraíba - IESP	Instituto de Educação Superior da Paraíba - IESP	https://ensaiosclinicos.gov.br/rg/RBR-10vnmdb7	<NULL>	Volunteers both genders, with medication-resistant hypertension; older than 18 years; non-smoking; no history of ischemic or hemorrhagic stroke, coronary heart disease, chronic obstructive or restrictive pulmonary disease, and chronic atrial fibrillation; be able to participate in the research protocol; do not practice regular physical exercise; be available to undergo the experimental protocol	Volunteers who modify the initial medication pattern; practice another type of physical exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-10zrb5sh	Effect of Aerobic Eexercise at different times of day on severity of obstructive sleep apnea, blood pressure and cardiac autonomic modulation in Obstructive Sleep Apnea patients	Recruiting	Intervention	2023-09-22	<NULL>	<NULL>	7172	Effect of Moderate Intensity Aerobic Exercise sessions prescribed at different times of day on severity of Obstructive Sleep Apnea, blood pressure and cardiac autonomic modulation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Complexo Hospitalar Hospital Universitário Oswaldo Cruz - HUOC/Pronto-Socorro Cardiológico de Pernambuco - PROCAPE	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10zrb5sh	<NULL>	Prior diagnosis of Obstructive Sleep Apnea - OSA (apnea hipopnea index above five events/hour); overweight; be aged above eighteen years; both genders	Having uncontrolled high blood pressure; cerebrovascular disease; kidney failure; arrhythmias; musculoskeletal limitations that compromise exercise performance; adhere to another treatment for Obstructive Sleep Apnea - OSA; did not complete the four experimental sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-95vw7sj	Effect of Aerobic Exercise on Anxiety level in healthy individuals	Not yet recruiting	Intervention	2023-11-08	<NULL>	<NULL>	6566	Comparison of the acute effect of Aerobic Exercise performed at different intensities on State Anxiety level in healthy individuals exposed to anxiogenic stimuli	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-06	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-95vw7sj	<NULL>	Both gender; aged between 18 and 40 years old; be literate	Be in the menstrual period (applicable for women); use psychotropic drugs;have restrictions to perform physical exercise (determined by the Physical Activity Readiness Questionnaire); have a diagnosis of anxiety disorder and/or depression; being in the gestational period (applicable to women)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-8fdwth	Effect of aerobic training combined with strength training with an elastic tube on the functional capacity of the elderly	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3586	Functional, hemodynamic and neuromuscular modifications in hypertensive subjects submitted to concurrent training and resistance training with elastic tube	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Santa Catarina	Programa de Pós-graduação em Educação Física	https://ensaiosclinicos.gov.br/rg/RBR-8fdwth	<NULL>	The inclusion criteria were: age equal to or greater than 50 years; not practicing systematic training in the last 6 months and; have medical clearance for physical exercise.	Individuals were excluded if any disease that could be aggravated by training; muscle or joint limitations; did not reach 85% of the total number of planned sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-5cgp6h	Effect of aerobic training combined with strength training with elastic tube on functional capacity, blood pressure and muscular strength in hypertensive patients	Recruitment completed	Intervention	2018-09-15	<NULL>	<NULL>	2201	Functional, hemodynamic and neuromuscular modifications in hypertensive subjects submitted to concurrent training and resistance training with elastic tube	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Santa Catarina	Programa de Pós-graduação em Educação Física	https://ensaiosclinicos.gov.br/rg/RBR-5cgp6h	<NULL>	Inclusion criteria were: aged 50 years or older; controlled hypertension (&lt;140/90 mmHg); and medical release for physical exercise.	Subjects were excluded if they had participated in an aerobic and/or resistance training program in the previous 6 months; presented congestive heart failure; recent myocardial infarction; or joint or muscular limitations that compromised the movements in any of the exercises; did not meet the minimum of 85% of the total number of sessions planned.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-5q24zh	Effect of Aerobic Training on Blood Pressure Levels of Hypertensive Subjects	Recruiting	Intervention	2015-08-28	<NULL>	<NULL>	600	Effects of Aerobic High Intensity Training on Blood Pressure Levels of Resistant Hypertensive	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Laboratório de Estudos do Treinamento Físico Aplicado à Saúde	Programa Associado de Pós-Graduação em Educação Física UPE/UFPB	https://ensaiosclinicos.gov.br/rg/RBR-5q24zh	<NULL>	Age between 40 and 60 years; men or women; body mass index under 30 kg / m²; able to participate in exercise; no regular physically active in the last 4 months	Smoking; with history of ischemic stroke or hemorrhagic; or CHD; or obstructive pulmonary disease or chronic restrictive; or diabetes mellitus; or chronic atrial fibrillation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-69c4qq	Effect of aged garlic extract on cardiovascular health: a randomized 12-week placebo-controlled study	Recruiting	Intervention	2019-06-03	<NULL>	<NULL>	3251	The effect of aged garlic extract on the blood pressure of hypertensive patients and their relationship to the nutritional status of vitamins b6, b9 and b12	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2019-04-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-69c4qq	<NULL>	Arterial hypertension	Psychiatric disorder; allergy to garlic and sulfur; terminal illness; anemia; infection; pregnancy; use of multivitamin or garlic supplement in the last 6 months; can not give informed consent; are participating in another clinical trialand and malnutrition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-9k773yq	Effect of alginate/biocellulose dressings containing graphene and silver (Grafderm) and biocellulose with papain (Tecderm) on healing of diabetic ulcers	Recruitment completed	Intervention	2024-10-09	<NULL>	<NULL>	7414	Evaluation of alginate/biocellulose dressings containing graphene and silver (Grafderm) and biocellulose with papain (Tecderm) in the healing of diabetic ulcers: randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-10-02	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9k773yq	<NULL>	Diabetic patients; of both genders; outpatient clinics with neuropathic diabetic ulcers; aged between 18 and 80 years; with a maximum of 4 weeks of lesion development	Those with a known allergy to any of the components of the dressings; to possess ulceration with exposed tendon, periosteum or bone, bone infection (osteomyelitis acute) and soft tissue infection requiring treatment with systemic antibiotics; ulcer on a limb being considered for revascularization or debridement surgical; patients receiving medications (such as corticosteroids, immunosuppressants or chemotherapy) in the last six months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-2wpryx	Effect of almond consumption baru on the levels of cholesterol, free radicals and inflammation in overweight women	Recruitment completed	Intervention	2015-02-25	<NULL>	<NULL>	404	Effect of almond consumption baru on the lipid profile, oxidative stress and inflammatory women overweight	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-10-31	Hospital das Clínicas - Universidade Federal de Goiás	Faculdade de Nutrição - Fanut/UFG	https://ensaiosclinicos.gov.br/rg/RBR-2wpryx	<NULL>	Female volunteers; diagnosis of overweight or obesity; aged between 20 and 60 years, who receive care in outpatient clinics of general nutrition and nutrition Endocrinology, Hospital das Clinicas, Federal University of Goiás	Volunteer smokers, pregnant or lactating; volunteers with prescription diets for weight reduction; with Body Mass Index below 25 kg/m2 or 40 kg/m2; diagnosis of autoimmune diseases, hepatic or renal diseases; history of drug abuse or alcohol; use of dietary supplements; volunteers who are receiving medications a week before the study or during the performance; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-95xwz8	Effect of alpha-lipoic in the control of acute pain and levels of biomarkers in surgery  of femur fracture	Data analysis completed	Intervention	2018-12-18	<NULL>	<NULL>	2394	Effect of alpha-lipoic acid as adjuvant in the control of acute pain and levels of biomarkers in surgery for correction of femur fracture	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Instituto Doutor José Frota	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-95xwz8	<NULL>	Patients older than 18 years and less than 65 years of age, of both sexes, with physical status ASA I and ASA II according to the American Society of Anesthesiologists (ASA) Anesthetic Care Guidelines, scheduled for elective surgery in femur fracture correction	Volunteers who were hypersensitive to any of the drugs used in the study, who were pregnant, had kidney disease, coagulation disorder, puncture site infection, clinical signs of hypovolemia, who could not collaborate with the evaluation of postoperative analgesia and users of illicit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-62q6tf	Effect of amber stone necklace / bracelet with improvement of tooth eruption symptoms, and its benefits against anxiety in dental treatment in children	Recruiting	Intervention	2020-08-18	<NULL>	<NULL>	4137	"Effect of the amber necklace / bracelet on the symptoms of tooth eruption and its
benefits against anxiety in dental treatment in infant patients"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-26	Faculdade de Odontologia da UFRJ	Faculdade de Odontologia da UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-62q6tf	<NULL>	"The inclusion criteria in the sample will be babies between 8 and 36 months of age who have at least one erupting primary dentition tooth (without natal or neonatal teeth) and that the parents are already familiar with the initial symptoms of the tooth eruption;
The inclusion criteria in the sample 2 will be children between 7 and 12 years old who already have a history of anxious profile in dental consultations; showing fear and apprehension during consultations, making dental care difficult and completing the questionnaire have moderate to high anxiety results."	"The exclusion criteria will be children with cognitive impairment (assessed by the pediatrician); history of medical treatment for any systemic disease that may influence the signs and symptoms of teething; current drug treatment, not using drugs for local use; use of teethers that relieve the symptoms of tooth eruption and pacifiers; oral or dental anomalies or deficiencies; and lack of parental consent to participate in the research.
Exclusion criteria in phase 2 will be children with cognitive impairment (assessed by the pediatrician), history of medical treatment for any systemic disease that may influence the signs and symptoms of anxiety, children with hormonal problems related to cortisol or who use corticosteroids for up to 30 days prior to the beginning of the research; current drug treatment, including tranquilizers and anxiolytics, both pharmaceutical and natural; which may interfere with the results of the use of the amber necklace; as well as the lack of consent from parents or children to participate in the research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-6dpzvty	Effect of Amitriptyline Cream on Muscle and Joint Pain	Not yet recruiting	Intervention	2023-06-19	<NULL>	<NULL>	6160	Effect of Base Cream with 5% Amitriptyline on Orofacial Pain: Muscle and Joint	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6dpzvty	<NULL>	Age equal to or greater than 18 years; Undergraduate and postgraduate students at the Piracicaba School of Dentistry; Complaint of persistent facial and/or joint pain (TMJ) present for at least 3 months that corresponds to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) (Pereira and Gonçalves, 2020; Schiffman, 2014). The diagnostic nomenclature of Axis I and Axis II of DC/TMD will be used; Having accepted and signed the Informed Consent Form	Under 18 years old; Present other pain syndromes; Refusal to adhere to treatment using topical drugs; Report an allergy to any component of the formula; Make use of antidepressant, anticonvulsant and anti-inflammatory; Be under the direct supervision of the researchers (developing some type of activity in undergraduate and postgraduate courses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-42t9xmy	Effect of an Abdominal Strengthening Exercise Protocol in university students with Chronic Non-Specific Low Back Pain: A randomized clinical trial	Not yet recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8585	Development and validation of a CORE Stabilization Exercise Protocol in university students with Chronic Non-Specific Low Back Pain: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de Alfenas- UNIFAL-MG	<NULL>	<NULL>	<NULL>	The criteria will be men and women aged between 18 and 60 years; who have low back pain with or without back stiffness for more than 3 months; self-reported pain at a score of 3 or more on the Visual Numerical Scale (VNS); willing to participate and be randomly allocated to the study groups; availability of time to carry out the intervention in the space provided by the Faculty of São Lourenço	Exclusion criteria include fractures or surgery of the spine or lumbar region; history of spinal cord trauma; tuberculosis; cancer; pregnancy, breastfeeding, or planning a pregnancy during the study period; rejection, fear, or unavailability of the proposed interventions; having undergone any therapy or other spinal treatment in the last three months prior to the study; receiving physical therapy concomitantly with the proposed intervention; patients with psychiatric conditions accompanied by difficulty understanding; severe systemic disease; inability to complete research questionnaires; and ongoing use of medications such as corticosteroids, muscle relaxants, or analgesics	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-5dvnbqx	Effect of an Adapted Ice Cream on Cancer patients during Chemotherapy	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5709	Effect of Adapted Ice Cream ingestion on nutritional, inflammatory and oxidative stress indicators, incidence of oral mucositis and quality of life of individuals with Cancer undergoing Chemotherapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-20	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani de São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-5dvnbqx	<NULL>	individuals aged 19 years or over; both sexes; with recent clinical diagnosis of hematologic cancer or head and neck cancer and with indication to start chemotherapy treatment; in conditions of oral ingestion.	in palliative care; using statins and/or other anti-inflammatory drugs; who have undergone anticancer treatment in the 5 years prior to the survey; diagnosed with infectious contagious diseases; with indication for the use of enteral or parenteral nutrition; who have taken dietary supplements in the 6 months prior to the study; and who have an intolerance or allergy to any component of the adapted ice cream. Pregnant and lactating women will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-6t6grh7	Effect of an ankle-focused Global Exercise program on static posture balance, task stability, and functionality in individuals with Ankle Instability	Not yet recruiting	Intervention	2023-09-05	<NULL>	<NULL>	6408	Effect of a Global Rehabilitation program with local emphasis on static postural control, stability, dynamics and functionality in individuals with lateral ankle Instability - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-30	Escola de educação física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de educação física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6t6grh7	<NULL>	The sample of this study will be for convenience and will consist of individuals of both sexes; aged between 18-45 years; body mass index less than 30 kg/m²; with no history of other injuries in the lower limbs; without acute ankle sprains ( minimum three months prior to the collection); who do not participate in other rehabilitation programs; and who report the presence of the following criteria: having a history of at least one ankle sprain associated with pain requiring a change in gait pattern; avoiding weight bearing on the foot affected for at least one day; present a feeling of weakness, pain or instability that appeared after the traumatic ankle event; present a score less than or equal to 24 on the Cumberland Ankle Instability Tool	Individuals who are unable to attend the reassessments (cannot be contacted or have an injury that prevents the proposed tests from being carried out) and who initiate some other type of treatment after the start of the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-3dw33z	Effect of an Aquatic Training (Egg Beater) on the Hip Rotator Muscles	Recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3580	Effect of Water Polo Training (Egg Beater) on Hip Rotator Muscles Performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-03	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-3dw33z	<NULL>	Healthy and sedentary volunteers; both genders; age between 18 and 60 years; not having undergone surgical procedures; not having undergone hip rehabilitation; not having undergone a musculoskeletal injury to the lower limbs / trunk in the last 6 months; perform less than 2 days a week of muscle strengthening or resistance activities; know how to swim; present minimum clinical and cognitive conditions for performing activities in the pool through the Physical Activity Readiness Questionnaire (PAR-Q); not presenting contagious dermatological changes; urinary and fecal incontinence.	Failure to perform the passive stiffness test of the hip lateral rotators; at the request of the volunteer himself; changes in the routines of the volunteers in the control group, lack of more than 15% in the interventions. Presence of muscle contraction during the passive RL stiffness test of the hip. Pain reported during the procedure that prevents its correct execution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-66fjrf2	Effect of an Educational Intervention for informal caregivers of elderly people with Dementia	Recruitment completed	Intervention	2024-08-08	<NULL>	<NULL>	7190	Effectiveness of an Educational Intervention for informal caregivers of elderly people with Dementia: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Fauldade de Enfermagem da Universidade Federal de Mato Grosso	Fauldade de Enfermagem da Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-66fjrf2	<NULL>	Being 18 years of age or older; being the main caregiver of an elderly person with dementia; having access to a smartphone with internet and knowing how to use a messaging application	Have difficulty communicating, hearing and understanding the questions asked by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8wyp8j	Effect of an educational intervention for the prevention of complications of Gestational Hypertension Syndrome	Recruitment completed	Intervention	2018-05-17	<NULL>	<NULL>	1809	Effect of an educational intervention for the prevention of complications of Gestational Hypertensive Syndrome: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Faculdade de Enfermagem da Universidade Estadual de Campinas	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-8wyp8j	<NULL>	Pregnant women; gestational age up to 33 weeks; literate	Pregnant women over 33 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-57nftj	Effect of an educational intervention on adherence to treatment for Syphilis in postpartum women and their partners	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1885	Impact of an educational intervention on the follow-up of postpartum women with Syphilis and their sexual partners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	UFG- Hospital das clínicas da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-57nftj	<NULL>	Minimum age of 18 years; 6 hours after delivery; Infection by Treponema pallidum in prenatal, childbirth, immediate pre-delivery and / or puerperium; Indication of treatment in the last 30 days before delivery or in the puerperium; Non-treponemal test (VDRL) reagent in any titration; Record of inadequate treatment for prenatal syphilis	Inability to answer questions on forms and questionnaire; To present a diagnosis of mental disorders recorded in medical records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-4g5fwbn	Effect of an educational intervention on patients with diabetes	Recruitment completed	Intervention	2021-08-20	<NULL>	<NULL>	4846	Evaluation of the impact of a Problematizing Pedagogical Intervention in the care of Diabetic Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-03	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4g5fwbn	<NULL>	This is a convenience sample made up of individuals with type 2 diabetes mellitus; age between 18 to 64 years; on insulin therapy; with serum glycated hemoglobin levels higher than 7.0 percent.	Patients with other types of diabetes; institutionalized; patients with other chronic complications in advanced stages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-4fvfn2p	Effect of an educational manual for preventing or reducing the workload of caregivers	Recruitment completed	Intervention	2021-09-28	<NULL>	<NULL>	4919	Educational innovations to prevent/reduce burden on caregivers	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-05	Escola de Enfermagem da Universidade Federal da Bahia	Centro de Referência Estadual de Atenção a Saúde do Idoso	https://ensaiosclinicos.gov.br/rg/RBR-4fvfn2p	<NULL>	Being a caregiver of elderly people linked to the institution, family or not, being 18 years old or over; exercising the role of caregiver for at least twelve months, having access to the internet, whether through a computer, notebook, tablet or smartphone.	Caregivers who, after five attempts to call, do not answer and do not return the call.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-79zrm8y	Effect of an educational program on antibiotic dispensing quality in community pharmacies: a multicenter study	Not yet recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9080	Impact of an Educational Program on the quality of antimicrobial dispensing in community pharmacies: a multicenter study	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Pharmacists working in private community pharmacy chains; who perform medication dispensing; aged over 21 years; male or female; holding a higher education degree in Pharmacy; and who agree to participate in the study voluntarily	Pharmacists who are unavailable to participate in the educational program; who may compromise the anonymity of the simulated patient; whose data cannot be collected after the intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-2jws7dv	Effect of an Educational Technology about sex transmitted Infections for women deprived of liberty	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5197	Educational Technology on Sexually Transmitted Infections for incarcerated women: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2jws7dv	<NULL>	Incarcerated women, regularly enrolled at the Olga Benário Prestes State School that operates within the chosen prison unit and with a minimum stay of 2 months.	Women who were not authorized by the prison unit or school administration for conduct that represents a risk for those involved; and pregnant women, for presenting information about STIs during prenatal consultations, which can be considered a bia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-8dmynv	Effect of an educational video on the promotion of self-care with arteriovenous fistula	Not yet recruiting	Intervention	2020-04-06	<NULL>	<NULL>	3706	Promotion of self-care with the arteriovenous fidtulaa through an educational video: randomized clinical test	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8dmynv	<NULL>	Patients with arteriovenous fistula for at least six months; both sexes; age over 18 years.	mental or cognitive disorder that makes it impossible to apply the data collection instrument.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-7m2756	Effect of an exercise program on cardiopulmonary function and quality of life in patients after gastric bypass surgery	Not yet recruiting	Intervention	2015-07-30	<NULL>	<NULL>	568	Impact of an exercise program on cardiopulmonary function, functional capacity and quality of life in patients undergoing Bariatric Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7m2756	<NULL>	Obese patients who are part of the Surgery of Obesity and Related Disorders (SCODE) of HUOL and UFRN; target sample of 24 subjects; having a BMI above 30 kg / m2; both genders; aged between 18 and 50 years; presented FVC and FEV1 values above 80% of the predicted age obtained in spirometry; signed an informed consent form.	Cognitive and / or neurological disorders; orthopedic impairments; diagnosis of chronic obstructive pulmonary disease (COPD) and / or severe cardiovascular disorders such as unstable angina, valvular heart disease, acute arrhythmias, acute myocardial infarction in the last month, high blood pressure and / or uncontrolled diabetes mellitus; presence of cardiac pacemakers; patients who present contraindications to perform the Cardiopulmonary Exercise Test III Guidelines established by the Brazilian Society of Cardiology About Exercise Stress Test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-3p3nz8	Effect of an interdisciplinary treatment on the consumption of industrialized foods in overweight women.	Recruiting	Intervention	2019-09-26	<NULL>	<NULL>	3002	Effect of an interdisciplinary intervention on the consumption of ultra-processed foods in overweight women.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Ana Paula Grotti Clemente	Ana Paula Grotti Clemente	https://ensaiosclinicos.gov.br/rg/RBR-3p3nz8	<NULL>	"Intervention Group: Women; aged 19 to 45 years; overweight; residents of Denisson Menezes or its surroundings; among the first 55 people to appear at the service with interest to participate in the protocol.
Control Group: Women aged 19 to 45 years old; overweight; residents of Denisson Menezes or its surroundings; between position 56 and 110 of the list of interested subscribers to participate in the study."	Women who have previously taken anabolic androgenic steroids or psychotropic drugs; pregnant women; lactating women; and individuals who have experienced morbid resulted in prolonged hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-8dmbzc	Effect of an Intervention in Coping with Occupational Stress in firefighters military	Recruitment completed	Intervention	2020-09-23	<NULL>	<NULL>	6037	Effectiveness of an Intervention on the Management of Occupational Stress in military firefighters: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-29	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8dmbzc	<NULL>	Firefighters of both sexes; without sick leave during the collection period; residents in the city of Uberaba.	Firefighters who were undergoing psychological therapeutic treatment, as this fact could interfere with the intervention that the participant would receive.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-9t2jr8	Effect of an intervention on behavior change in adolescents with Excess of Weight in the Centre for Nutritional Recovery and Education (CREN) - Project I learned, I taught	Recruiting	Intervention	2017-01-24	<NULL>	<NULL>	1166	"Effectiveness of multidisciplinary intervention based on the Transtheoretical Model
Of Behavior Change for the treatment of adolescents with Excess of
Weight in the Centre for Nutritional Recovery and Education (CREN) - Project I learned,
I taught"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-22	Universidade Federal de São Paulo	Centro de Recuperação e Educação Nutricional	https://ensaiosclinicos.gov.br/rg/RBR-9t2jr8	<NULL>	Schoolchildren; aged 8 to 12 years; enrolled in the two eligible schools; enrolled in the third, fourth and fifth years of elementary education.	Schoolchildren with cognitive delays selfreported by parents and  or teachers who could limit their involvement in activities such as responding to questionnaires; That have motor limitations to participate in physical activities; that are twins; Who are using known medications that influence body weight; Who have known family problems that could affect overall compliance and participation in the Program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-10y32ztc	Effect of an intervention performed by telephone on the self-efficacy of adolescents&apos; with type 1 diabetes	Recruitment completed	Intervention	2023-02-03	<NULL>	<NULL>	5862	Effect of an Educational Intervention on the type 1 Diabetes Mellitus adolescents&apos; self-efficiency	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-04	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10y32ztc	<NULL>	Adolescents aged between 14 and 19 years old diagnosed with Diabetes Mellitus type 1 for at least six months; accompanied regularly in the service; with phone access	Adolescents who had any cognitive or behavioral difficulties that prevented communication from effectively participating in the interview	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-2xx2z4	Effect of an intervention program for nutrition education and physical activity in the prevention of obesity in schoolchildren	Terminated	Intervention	2014-08-14	<NULL>	<NULL>	326	Effect of an intervention program with nutrition education and physical activity in the prevention of obesity in school children: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-10	Hospital de Clínicas de Porto Alegre (HCPA) da Universidade Federal do Rio Grande do Sul	Programa de pós-graduação em saúde da criança e do adolescente da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2xx2z4	<NULL>	Students of both sexes, who are regularly enrolled and regulars from first to fourth year of elementary school in the afternoon of the schools in the city of Porto Alegre-RS.	Students with disabilities to perform the anthropometric measures and special needs . In addition to the students who did not agree to undergo anthropometric measures and participation in the intervention program .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-9rrqhk	Effect of an intervention program in the implementation of healthy school canteens	Other	Intervention	2018-07-11	<NULL>	<NULL>	4067	Effect of an intervention program in the implementation of healthy school canteens: a randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Rio Grande do Sul	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-9rrqhk	<NULL>	Primary and Secondary Schools of the public and private network of the “Território da Cidadania do Noroeste Colonial”, in RS, that own sales structure in canteen format at the school	Schools with exclusive care for children with special needs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-6zvxsdb	Effect of an intervention with Electrical Stimulation of the brain through the skull bones associated with Motor Exercises on motor symptoms in people with Parkinson&apos;s disease	Not yet recruiting	Intervention	2024-10-21	<NULL>	<NULL>	7444	Effect of an intervention with Electrical Stimulation on the brain through the skull bones combined with exercises on locomotion and balance in individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Faculdade de Ciências e Tecnologia - Universidade Estadual Paulista	Faculdade de Ciências e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6zvxsdb	<NULL>	Individuals with Parkinson&apos;s Disease; of both sexes; they must have the disease diagnosed by doctors following the criteria determined by the London Brain Bank; age equal to or greater than 50 years; and present independent locomotion (without assistance from people or use of auxiliary devices)	Staging greater than 3 on the Hoehn &amp; Yahr scale; orthopedic and vision problems that make it impossible to comply with the experimental protocol; presence of another neurological disease, in addition to Parkinson&apos;s Disease (PD); indicative of cognitive decline (score less than 24 on the Mini Mental State Examination - MMSE); individuals at risk of receiving Transcranial Direct Current Stimulation - tDCS (e.g., neural implants, individuals with deep brain stimulation implants, pacemaker, history of seizures and epilepsy); have uncontrolled diseases (e.g. high blood pressure and diabetes); experience intense pain or discomfort that makes it impossible and difficult to perform motor exercises; and not understanding the motor exercises proposed in the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-8v2qmk	Effect of an Intervention with Food Counseling and Physical Exercise Practice on the reduction of cardiac risk and costs for the single health system in patients with high blood pressure	Recruitment completed	Intervention	2018-10-09	<NULL>	<NULL>	2268	Effect of a Nutritional Intervention Associated with Physical Exercise in reducing cardiovascular and custodial risk of the single health system in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Federal do Vale do São Francisco	Hospital Universitário da Universidade Federal do Vale do São Francisco (HU-Univasf)	https://ensaiosclinicos.gov.br/rg/RBR-8v2qmk	<NULL>	To have a diagnosis of hypertension; have an age group between 30 and 50 years; accept to participate in the research and sign the Free and Informed Consent; own mobile phone with Android system; has no medical contraindication for the practice of physical activity and must have a medical release certificate.	Patients who refuse to follow the recommendations and test protocols will be excluded; difficult contact and / or inability to return and follow up during the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-74jbmn	Effect of an oral health promotion intervention in primary health care	Recruiting	Intervention	2016-03-28	<NULL>	<NULL>	765	Implementation and evaluation of an oral health promotion intervention for children aged zero to five years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-74jbmn	<NULL>	It will be included Primary Health Care Centers belonging to the urban area, that have family oral health team working for at least one year, at least 200 children from zero to five years old enrolled, offering postpartum care and childcare. All children enrolled in Primary Health Care Centers aged between 0 and 3 years old will be eligible to participate.	Primary Health Care Centers that are holding other interventions in oral or nutritional health, which have different work process will be excluded. It will be excluded children whose families wish to move in within six months of the baseline study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-9yffqb7	Effect of analgesic and anti-inflammatory current on muscle strengthening in patients with knee arthrosis. Blind randomized clinical trial	Not yet recruiting	Intervention	2021-10-08	<NULL>	<NULL>	4951	Additional effect of diadynamic currents in a strengthening program muscle in patients with knee arthrosis. Blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	FMRP - USP (Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo)	UNISALESIANO LINS	https://ensaiosclinicos.gov.br/rg/RBR-9yffqb7	<NULL>	Patient with knee osteoarthritis (Kellgren and Lawrence classification grades II and III); Age between 50 and 70 years and; Pain equal to or greater than 3 at rest and / or equal to or greater than 5 after a 6-minute walk test; Whether a bilateral OA will be considered the side most affected.	Occurrence of great discomfort after performing the exercises and / or applying electrical stimulation; Failure to perform the exercises during two consecutive sessions; Also excluded are patients who for any reason no longer wish to participate in the research or have any of the criteria for non-inclusion in the period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-36srkn	Effect of anesthesia associated or not with adrenaline, related to pharmacodynamics, pharmacokinetics and pharmacogenetics.	Recruiting	Intervention	2019-11-12	<NULL>	<NULL>	3183	Pharmacogenetic study and PK / PD after infiltrative application of lidocaine with or without adrenaline in saliva samples by LC MS / MS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-36srkn	<NULL>	"The participant must be in treatment at LAFFIC and should be in good general health,
with no infection and no systemic disease. To be included in the research, the participant must not be taking any medication that could alter their perception of pain, or even antidepressant, diuretic or anticoagulant medications. These data will be verified in the anamnesis form contained in the FOB / USP medical record and / or updated before scraping and evaluation of each participant&apos;s general health history."	Patient with periodontal disease; patients with systemic diseases; patients with infection at the scraping site; patients with cardiovascular, renal or liver disease; patients taking antidepressant, diuretic or anticoagulant medications; patients with a history of allergy to any local anesthetic or vasoconstrictor; pregnant and lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-9j49xsg	Effect of anesthesia on abdominal wall during video surgery in patients undergoing intestinal resection: a double-blind, randomized clinical study	Data analysis completed	Intervention	2024-09-06	<NULL>	<NULL>	7321	Analgesic effect of laparoscopic-guided transversus abdominis plane block (TAP block) in laparoscopic colorectal surgery: a randomized, double-blinded trial	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2021-08-09	Hospital Governador Israel Pinheiro	Hospital Felício Rocho	https://ensaiosclinicos.gov.br/rg/RBR-9j49xsg	<NULL>	Volunteers with an indication for segmental colon resection; aged 18 years or older; elective surgical proposal; laparoscopic surgery proposal; both sexes	Volunteers with pre-anesthetic assessment ASA IV-V; a history of allergic reactions to local anesthetics; complaints of chronic pain, chronic opioid use, or opioid tolerance; the need for resection of organs other than the colon, rectum, and/or cecal appendix; preoperative signs of intestinal obstruction; surgical indication for laparotomy access; signs of inflammation or infection at the TAP block puncture sites; surgeries for the treatment of neoplastic recurrence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-6yv2xry	Effect of anesthetic ankle block, through local infiltration of medications Dexmedetomidine and Ropivacaine, for postoperative pain relief: a study with random selection of patients	Not yet recruiting	Intervention	2021-06-29	<NULL>	<NULL>	4767	Effect of Dexmedetomidine added to Ropivacine on ankle block for postoperative analgesia: randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-08-01	Instituto Prevent Senior	Instituto Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-6yv2xry	<NULL>	Inclusion criteria are: adults undergoing foot surgery (hallux valgus correction, claw toes and tailor&apos;s bunion), of both genders, older than 18 years; having signed and agreed to the voluntary consent form to participate in the study (TCLE); not having a previous allergy or contraindication for the selected anesthetic procedure.	Exclusion criteria are: patients who are allergic to selected and offered anesthetic medications; refusal of the type of anesthetic procedure drawn and offered; anesthetic risk that contraindication is the type of anesthesia drawn and offered; patients with malignant tumors and infections present; patients with mental confusion or disoriented; patients under 18 years of age.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-8w8599	Effect of Anti Microbial Photodynamic Therapy on the Treatment of Oral Candidosis	Recruiting	Intervention	2019-12-09	<NULL>	<NULL>	3260	Use of Anti-Microbial Photodynamic Therapy in the treatment of Oral Candidose: Clinical, controlled and randomized test	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-05-08	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8w8599	<NULL>	Cases of patients with erythematous candidiasis located in the oral mucosa; Patients older than 18 years and under 100 years old; Patients who do not receive treatment for other diseases with systemic antifungal	Patients with other types of oral candidiasis; Pregnant women; Patients who did not receive nystatin treatment at least six months prior to the start of the study; Patients who do not attend for follow-up;Patients older than 100 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-89495pk	Effect of anti-inflammatory injection on the success of anesthesia in lower molar teeth in cases of toothache	Not yet recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9125	Efficacy of submucosal Dexamethasone infiltration in anesthetic success in inferior alveolar nerve block, in cases of Symptomatic Irreversible Pulpitis in mandibular molars: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-10	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Individuals over 18 years of age of both sexes diagnosed with symptomatic irreversible pulpitis in the first or second mandibular molars; reporting moderate to intense pain at the time of initial assessment; with a score of 4 or higher on the Numerical Pain Scale (NPS); classified as healthy and immunocompetent according to the criteria of the American Society of Anesthesiologists (ASA); adapted for the dental clinic; who demonstrate full comprehension of the pain assessment scales and the informed consent form	Patients who after the start of the procedure decide or need to abandon treatment before the completion of the dental procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-4xbyr8g	Effect of Antioxidant gel on aesthetic Restorations performed after in-office Tooth Bleaching	Not yet recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8697	Effect of Caesalpinia pyramidalis gel on aesthetic Restorations performed after in-office Tooth Bleaching: Eandomized clinical trial	<NULL>	3, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Programa de Pós-Graduação em Odontologia	<NULL>	<NULL>	<NULL>	Participants must be over 18 years of age; have good oral hygiene; not have periodontal disease; have at least two Class III restorations with vestibular access in the upper anterior teeth; not have undergone whitening treatment in the last 3 years; and have a right upper canine with a color of A2 or darker	Pregnant and breastfeeding women; volunteers with a history of allergies to dental products and who use orthodontic appliances. The selected teeth must not present caries lesions, pulpitis, endodontic treatment, dentin hypersensitivity, or absence of adjacent and antagonist teeth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-8r23ds	Effect of applying therapy with light emitting diodes on healthy men	Recruitment completed	Intervention	2019-02-06	<NULL>	<NULL>	2470	Acute effect of phototherapy by means of light emitting diodes (LEDs) on cardiovascular coupling after constant loading exercise in patients with type 2 diabetes mellitus	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8r23ds	<NULL>	Healthy men; aged 20-35 years	Cardiovascular and respiratory disorders; occurrence of a cutaneous lesion or local infection in the forearm area; history of skeletal muscle injury in the previous six months; and chronic joint disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-8m7hy7	Effect of Aquatic and Conventional Physiotherapy in Lumbar Spinal Stenosis patients	Recruitment completed	Intervention	2016-08-15	<NULL>	<NULL>	960	Effect of Aquatic and Conventional Physiotherapy on gait, pain, clinical and functional aspects in Lumbar Spinal Stenosis patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-15	Federal University of Rio Grande do Sul	Escola de Educação Física, Fisioterapia e Dança  - UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-8m7hy7	<NULL>	Patients of both genders, aging between 30 and 80 years old; diagnosed with Lumbar Spinal Stenosis, confirmed by recent imaging exam;	Patients should not present hystory of spinal or hip cirgury,  tumors or spinal infections, uncontrolled hipertension, urinary incontinence, hidrofobia, oppen wounds or fungic infections; They have to have the ability to make and participated all test; Will be excluded participants that had more than two consecutive absences, three alternate absences, or more that a total of 40 minutos late during intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6gx9y3	Effect of aquatic exercises on the health of patients with rheumatoid arthritis	Data analysis completed	Intervention	2019-04-16	<NULL>	<NULL>	2600	Effect of hydrokinesitherapy on anxiety, depression and quality of life in patients with Rheumatoid Arthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade do Estado de Santa Catarina	Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPQ	https://ensaiosclinicos.gov.br/rg/RBR-6gx9y3	<NULL>	Female volunteers; Clinical diagnosis of rheumatoid arthritis; Present attestation that are suitable for the practice of aquatic activities; Age above 18 and with the disease in activity.	Lack of time to participate in the program, Physical incapacity to perform the physical exercise program, Heart disease or severe pulmonary disease; Resting systolic blood pressure above 180 mmHg, Dermatological problems, Urinary and / or fecal incontinence, Change medication or initiate another type of therapeutic intervention during the 12 weeks of the study and do not adapt to the aquatic environment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-3qpyh3y	Effect of aqueous propolis extract on gingival tissue healing	Recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5216	Evaluation of the effect of aqueous propolis extract on gingival tissue healing in smile correction surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Jéssica Gomes Alcoforado de Melo	Jéssica Gomes Alcoforado de Melo	https://ensaiosclinicos.gov.br/rg/RBR-3qpyh3y	<NULL>	"-Have another two millimeters of gingiva band visible to the smile.
-Show gum health.
-Have an indication to perform a smile correction in the upper arch of at least canine to canine (from teeth 13, 12, 11, 21, 22 and 23).
-Be healthy systemically.
-Agree to participate in the research by signing the Informed Consent Form and having received, verbally and in writing by the researchers, all information and clarifications."	Those who, even if they present indications for correction of the smile, need some postoperative rehabilitation procedure, due to the small size of the anatomical crown, and those who are allergic to any of the drugs used in the study (chlorhexidine, aqueous extract of propolis, will be excluded from the sample). , paracetamol, 2% mepivacaine with epinephrine 1:100,000).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-8dxp8m	Effect of Arginine-containing toothpaste on mineral gain and bioquimic and microbian composition of the dental plaque formed in situ	Data analysis completed	Intervention	2020-03-30	<NULL>	<NULL>	3685	Effect of Arginine-containing dentifrice on remineralization and bioquimic and microbian composition of the biofilm formed in situ	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-04-03	Faculdade de Odontologia da UFRGS	Faculdade de Odontologia da UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-8dxp8m	<NULL>	undergradueted and gratueted students in Dentistry at UFRGS;both genders; a favorable systemic health condition; not having used antibiotics in the 2 months preceding the study.	have an unfavorable systemic health condition; have used antibiotics during the 2 months preceding the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-27nnt5g	Effect of Aromatherapy on Nausea and Vomiting caused by Chemotherapy in patients with Breast cancer	Recruiting	Intervention	2024-10-22	<NULL>	<NULL>	7447	Effect of Aromatherapy on Nausea and Vomiting induced by Chemotherapy in patients with breast Cancer: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-04	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-27nnt5g	<NULL>	"Women. Be undergoing curative antineoplastic chemotherapy treatment, regardless of the histological type and staging of the tumor. Have undergone at least one cycle of chemotherapy. Have at least two cycles of chemotherapy to be performed. Be using a chemotherapy protocol that has emetic potential.
Be aged 18 or over. Be in a physical and cognitive condition to understand the Free and Informed Consent Form and to participate in the study by responding to the Morrow scale instrument and the sociodemographic and clinical questionnaire form"	Being delirious or mentally confused. Be on other types of cancer treatment, other than just antineoplastic chemotherapy. Have injuries or allergic processes on the face. Being pregnant. Have a history of chronic obstructive pulmonary disease, asthma or other respiratory disorder that may be exacerbated by strong odors, inability to smell fragrances, allergy or sensitivity to peppermint or any strong odor. Use another integrative therapy to treat chemotherapy-induced nausea and vomiting during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-35pt7vd	Effect of aromatherapy on sleep quality in elderly people	Recruiting	Intervention	2024-10-14	<NULL>	<NULL>	7431	Effect of aromatherapy on sleep quality in elderly people: double-blind, placebo-controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-35pt7vd	<NULL>	People of both sexes. Over 60 years of age who present changes in sleep according to the Pittsburgh Sleep Quality Index (PSQI) with a score ≥5. Be in a physical and cognitive condition to understand the Informed Consent Form and participate in the study by responding to the instrument: Pittsburgh sleep quality index (PSQI) and the sociodemographic and clinical questionnaire	Make use of other integrative practices to improve sleep quality. Have an allergy or intolerance to strong odors. Have irritation or lesions on the face. Have a history of known respiratory disorders, such as asthma, for example	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-6ynw9d6	Effect of Aromatherapy on tiredness, insomnia and quality of life of patients with Breast and Gastrointestinal Cancer undergoing chemotherapy	Recruiting	Intervention	2025-01-22	<NULL>	<NULL>	7673	Effect of Aromatherapy on fatigue, sleep quality and quality of life in patients with Breast and Gastrointestinal Cancer undergoing chemotherapy treatment: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-05	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6ynw9d6	<NULL>	Patients of both sexes; diagnosed with Breast or Gastrointestinal Cancer; over 18 years of age; who will begin the chemotherapy protocol	Patients who use sleep inducers; with cognitive deficit; who already use aromatherapy or who are allergic to Lavender or Bergamot essential oil	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-5hrnpd5	Effect of aromatherapy with Lavender on satisfaction with childbirth	Recruitment completed	Intervention	2022-05-30	<NULL>	<NULL>	5410	Evaluation of the possible benefit of the effect of Lavandula angustifolia on satisfaction with childbirth and postpartum in women treated at the maternity of regional hospital from São José - SC	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5hrnpd5	<NULL>	Pregnant women; primiparous; active labor	required cesarean section; glucocorticoids use in the last 30 days;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-79y4gg2	Effect of Articaine with Sodium Bicarbonate for Local Anesthesia in the Maxilla	Recruitment completed	Intervention	2024-09-17	<NULL>	<NULL>	7351	Comparison between 4% unbuffed Articaine and 1% buffered Articaine solutions in Infiltration in the Maxilla	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2022-10-13	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-79y4gg2	<NULL>	Only healthy participants; both genders; aged between 18 and 40 years will be included; provided they have prior experience with local anesthesia; no history of complications from local anesthesia; and have intact maxillary canines that are responsive to electrical stimulation using a &quot;Pulp Tester&quot;	Pregnant or lactating women; volunteers with systemic conditions that contraindicate anesthesia; those with a history of allergic reactions to any components of the anesthetic solutions used; and those with inflammatory conditions in the region will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-7rz7b2s	Effect of assisted standing on strength and muscle mass in patients with ICU-acquired weakness	Recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7328	Effect of passive orthotatism on muscle strength and mass of patients with weakness acquired in the ICU	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7rz7b2s	<NULL>	Patients of both sexes will be included; aged 18 years or over; clinical and surgical patients admitted to the HC/UNICAMP Adult ICU; without sedatives; patients with ICU-acquired muscle weakness with MRC less than or equal to 48; collaborative patients; with a Glasgow Coma Scale score greater than or equal to 8, with a motor response score equal to 6, for application of the MRC scale and surface electromyography; hemodynamic stability with mean arterial pressure greater than 65 mmHg with minimal or no use of vasoactive drugs; peripheral oxygen saturation greater than or equal to 90% with FiO2 less than or equal to 60% and PEEP less than or equal to 10cmH2O; patients and/or legal representatives who agree to participate in this study and sign the Informed Consent Form	Hemodynamic instability; recent acute myocardial infarction or cardiac arrhythmias proven by electrocardiogram; use of sedatives; use of high parameters in MV; fractures of lower limbs or upper limbs; use of external fixator; amputation of lower limbs or upper limbs; orthopedic alterations that limit orthostatism; significant calcaneal eschar; patients with deep vein thrombosis; patients with significant thrombocytopenia with values below 50. 000; hemiplegic patients; patients after spinal cord trauma; patients with neuromuscular diseases; patients with intracranial pressure monitoring and/or external ventricular shunt; patients with intra-aortic balloon; patients with fever greater than or equal to 37.8°C	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-2mdfgdm	Effect of associated therapies on gingival treatment in type 2 diabetic patients.	Not yet recruiting	Intervention	2021-08-11	<NULL>	<NULL>	4825	Effect of active oxygen and photodynamic therapy on the periodontal treatment of residual pockets in diabetes mellitus patient: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Faculdade de Odontologia de Araçatuba - FOA/UNESP	Faculdade de Odontologia de Araçatuba - FOA/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2mdfgdm	<NULL>	Clinical diagnosis of periodontitis; who have undergone periodontal treatment within a maximum of 3 months with at least 4 ps sites greater than or equal to 4mm with bleeding from probing; patients diagnosed with type 2 diabetes mellitus (HbA1c greater than or equal to 7.0%); have at least 15 teeth, excluding third molars.	Smokers or ex-smokers for more than 5 years; patients with anemia; cancer patient active and history of chemotherapy; history of antibiotic therapy in 6 months; history of anti-inflammatory therapy in the last 6 months; patients with blood disorders; pregnancy; patient in orthodontic treatment, patients who require prophylactic antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-5rp37x8	Effect of Auricular acupuncture for nausea and vomiting in adult Cancer patients	Terminated	Intervention	2024-07-25	<NULL>	<NULL>	7159	Effect of Auriculotherapy on the control of chemotherapy-induced nausea and vomiting in adult cancer patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-06	Universidade Federal de Alfenas (UNIFAL-MG)	Universidade Federal de Alfenas (UNIFAL-MG)	https://ensaiosclinicos.gov.br/rg/RBR-5rp37x8	<NULL>	Age 18 or over, regardless of gender; have a confirmed diagnosis of cancer, of any histological type and staging of the disease; during the data collection of the study be undergoing chemotherapy for adjuvant, neoadjuvant or palliative purposes; report the presence of nausea and/or vomiting; have time available to participate in the auricular acupuncture sessions; have a performance status equal to or less than three according to the Eastern Cooperative Oncology Group Performance Status	Inflammations, infections, ulcerations or deformities of the ear; use of hearing aids; confirmed or suspected pregnancy; allergy to microporous tape	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-563hhy	Effect of auricular acupuncture in breastfeeding	Recruiting	Intervention	2020-05-07	<NULL>	<NULL>	3819	Effectiveness of auricular acupuncture in breastfeeding: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-27	Escola de Enfermagem de Ribeirão Preto	Escola de Enfermagem de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-563hhy	<NULL>	Lactating mothers with low milk production will be enrolled in study, that is whose breastmilk volumes failed to meet their infants&apos; requirements; 18 and older; between 5 and 30 days of postpartum.	To make use of galactogogues drugs during the research period; Being a smoker; history of breast surgery (breast reduction surgery or breast implant); never had made the auricular acupuncture before; pregnancy and delivery with any complications; baby who have an weight smaller than 2.500g and larger than 4.000g; twin pregnancy; preterm birth; be allergic to any materials used in auricular acupuncture; make use of other energy therapies (herbal treatments, Reiki, Flower therapy, homeopathy, etc); the patient has no time available to do the treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-472dvp3	Effect of Auriculotherapy and Laser on pain treatment in patients treated at the family health unit	Recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6766	Effect of Auricular Acupuncture and Low Frequency Laser in the treatment of Pain in patients assisted in primary health care: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-472dvp3	<NULL>	Individuals aged 18 or over; that is accompanied by a Family Health Strategy (ESF); presents availability of place for treatment; who self-reports pain with greater intensity4 on the Visual Numerical Scale (VNS); in addition, agree to the Free and Informed Consent Form (TCLE)	Patients who; are continuously using pain relief medication; infection; inflammation or injury to the ear; anatomical changes in the hearing aid; allergy to crystals or microporous tape; undergoing treatment with energy therapies or that have been carried out in the last three months (such as, for example, aromatherapy; Bach flower remedies; systemic acupuncture; foot reflexology; homeopathy); pregnant women; and missing more than two consecutive sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-35n9nkj	Effect of Auriculotherapy on Anxiety in adults within the Basic Health Unit	Recruitment completed	Intervention	2022-09-22	<NULL>	<NULL>	5625	Effect of Auriculotherapy on Anxiety in adults in Primary Care: pilot clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-02	Universidade do Sul de Santa Catarina	Unidade Básica de Saúde Central do Município de Palhoça	https://ensaiosclinicos.gov.br/rg/RBR-35n9nkj	<NULL>	Over 18 years old; both sexes; medium and high anxiety level	Users who are being treated with the following drugs: psychotropic drugs, antibiotics, corticosteroids and anabolics; pregnant women in the first trimester of pregnancy; illiterate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-3dky3p	Effect of Bach flower remedies in stress relief  in nursing students	Recruiting	Intervention	2020-09-23	<NULL>	<NULL>	4283	Effect of flower remedies in reduction of stress in nursing students	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2019-08-13	Escola de Enfermagem da Universidade de São paulo	Escola de Enfermagem da Universidade de São paulo	https://ensaiosclinicos.gov.br/rg/RBR-3dky3p	<NULL>	Undergraduate nursing students; Baccaro Test score above 20 points.	Students using complementary practice (acupuncture, auriculotherapy, reiki, among others), herbal medicine, antidepressive or anxiolytic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-8q6z6kq	Effect of Bach Flower treatment on hope and quality of life in patients with Advanced Cancer	Not yet recruiting	Intervention	2022-05-19	<NULL>	<NULL>	5400	Effectiveness of Bach Flower therapy on hope and health-related quality of life of patients with Advanced Cancer: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Leonel dos Santos Silva	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8q6z6kq	<NULL>	Be over 18 years old; have a histologically proven diagnosis of any type of advanced (stage IV) cancer; Eastern Cooperative Oncology Group (ECOG): 0, 1, 2 or 3 characterized as: 0 (fully active); 1 (restricted from strenuous physical activity and able to perform work of a light or sedentary nature); 2 (self-care capacity without working conditions, remains out of bed 50% of the time) and 3 (limited self-care capacity, remains 50% of the time in bed or chair rest)	Continuous use of anxiolytic and antidepressant medications; use of some integrative or complementary health practice such as flower essences, chromotherapy, aromatherapy, acupuncture, reiki, therapeutic touch, among others; unable to maintain verbal and/or written communication by the assessment of the Eastern Cooperative Oncology Group (ECOG) 4 performance scale (completely limited and unable to perform self-care activities, totally confined to bed or chair)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-3dngn4	Effect of backward walking treadmill training on locomotor capacity after stroke	Recruiting	Intervention	2018-05-10	<NULL>	<NULL>	1776	Effect of backward training on locomotor capacity of individuals with hemiparesis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3dngn4	<NULL>	People with stroke living in the community will be eligible if they are: &gt; 6 &lt; 18 months after their first stroke;community-dwelling and have been discharged from formal rehabilitation ; capable of providing consent (Mini Mental State Exam score &gt; 23); older than 20 years of age; able to independently walk 10 m without walking aids &gt; 0.4 &lt; 1.2 m/s.	They will be excluded if they have: unstable cardiac status which would preclude participation in a moderate exercise program; severe cognitive deficits and/or language problems which might prevent them from following instructions during the data collection and/or interventions; adverse health conditions which might affect their walking capacity (eg, vestibular disturbances, severe arthritis, or other neurological disorders).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-10j4bw25	Effect of Balance Training and walking with a flat, flexible sole on elderly women with knee arthrosis	Recruiting	Intervention	2021-06-04	<NULL>	<NULL>	4724	Therapeutic effect of Balance and Gait Training with flexible minimalist shoes in elderly women with Knee Osteoarthritis: randomized clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-06-01	University Santo Amaro	University of São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10j4bw25	<NULL>	elderly women; 60 and 80 years old; knee arthrosis with grades 2 and 3; knee pain between 3 and 8; body mass index lower than 35 kg/m2; walk independently	Prostheses and / or orthoses in lower limbs; fractures in the last 6 months; hip and ankle arthrosis; dementia stage; physiotherapeutic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-6hp5h9	Effect of Balance Training in Older Adults	recruiting	Intervention	2013-01-15	<NULL>	<NULL>	169	Effect of a Perturbation-based Balance Training Program on the Reactive Neuromuscular Control in Older Adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-15	Universidade Estadual do Centro-Oeste	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6hp5h9	<NULL>	Healthy older, between 65 and 80 years, living in the community.	Presence of cardiovascular, neurological or vestibular diseases. Presence of musculoskeletal problems that interferes with static or dynamic balance. Peripheral neuropathies. Use of medication for central nervous system. Mini-mental State Examination (MMSE) score less than 19.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-8d67bt	Effect of Balance Training on Muscle Electrical Activity in Subjects with Functional Chronic Instability	Recruitment completed	Intervention	2013-09-26	<NULL>	<NULL>	295	Strategies postural reaction in healthy subjects and with a deficit in motor control underwent postural disturbances	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade do Estado de Santa Catarina	Josilene Souza Conceição (Laboratório de Controle Motor - Universidade do Estado de Santa Catarina)	https://ensaiosclinicos.gov.br/rg/RBR-8d67bt	<NULL>	aged 18 to 30 years of age; history of two or more ankle sprains, with at least a sprain in the last six months; sensation of ankle instability, ie, the feeling that the ankle &quot;out of place&quot; during functional activities (work, leisure and / or sport); and score below 28 on the validated Portuguese-Brazil version of Cumberland Ankle Instability Tool.	acute signs of inflammation (pain, heat, redness, swelling) at the ankle; and history of fractures, rheumatic problems, neurological, or any other disease in the lower limbs that could impair the performance of the tasks proposed by the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-4zdy9p	Effect of baru almond in coronary heart disease risk factors	Recruitment completed	Intervention	2014-03-19	<NULL>	<NULL>	279	Effec of baru almond in serum lipid and oxidative state in individuals with moderate hypercholesterolemia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-15	Faculdade de Nutrição - FANUT/UFG	Faculdade de Nutrição - FANUT/UFG	https://ensaiosclinicos.gov.br/rg/RBR-4zdy9p	<NULL>	Men and women alduts (19 - 60 years old); omnivores; BMI between 18.5 and 30 kilogram per meter squared; total cholesterol between 50-95 th percentile (NCEP - National Cholesterol Education Program): between 200 and 255 mg/dL for men and between 201 and 265 mg/dL for women,	Use of any nutritional intervention and/or drugs, such omega 3 or dietary fiber; vegetarians; presence of chronic diseases, such hypertension, diabetes, cardiovascular disease or cancer; chronic alcoholics (consumption more than 2 times a week); frequent consumption of nuts (more than 2 times a week); allergy of nuts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-8zmmgm	Effect of Baru Almond Intake by Adults with Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1924	Metabolic Syndrome: prevalence and effect of Physical Exercise and Nutritional Supplementation in adults and the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8zmmgm	<NULL>	Adult subjects; aged between 20 and 59 years; with self-reported diagnosis of type 2 diabetes mellitus	Individuals using insulin therapy; with a history of cardiovascular disease (infarct in the last six months, unstable angina, cardiac arrhythmia and stroke); cancer; diagnosed chronic lung disease; musculoskeletal problems ; neurological deficit; with frequent consumption of some type of nut (more than 2x / week); participants in a restriction and food education program; participants in a guided exercise program; individuals with nut  and / or seeds allergy, pregnant; nursing women; women in hormonal replacement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-24td8t	Effect of baru consumption on the blood fat profile of people with excess body fat and its relationship with genetics.	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4169	Effect of baru seed consumption on lipid profile of individuals with excess body fat: relation with apolipoprotein E genotype	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Faculdade de Medicina da Universidade Federal de Goiás	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-24td8t	<NULL>	The sample of this study included individuals between 20 and 59 years (age range adopted in the matrix study) who agreed to participate in the study, with BMI between 18.5 kg/m² and 24.99 kg/m² (WHO, 2005), percentage of body fat above the established parameters, according to sex and age range (POLLOCK; WILMORE, 1993), who did not habitually consume nuts (more than twice a week) and had increased cholesterol in low-density lipoproteins (LCL-C) serum concentrations, according to the Brazilian Society of Cardiology (SBC, 2013), confirmed by biochemical exams .	Individuals taking lipid-lowering drugs and/or vitamin and mineral supplements; who had allergies to nuts; under nutritional accompaniment; women who were pregnant, in menopause or hormone replacement therapy; patients presenting with acute clinical conditions such as infection, inflammation, fever or diarrhea, or chronic diseases such as diabetes mellitus, moderate/severe arterial hypertension, cancer, rheumatoid arthritis; subjects who were smokers or practiced moderate to intense physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-3b557kx	Effect of beetroot juice ingestion on strength	Recruiting	Intervention	2024-07-03	<NULL>	<NULL>	7116	Effects of nitrate supplementation on strength endurance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3b557kx	<NULL>	Males; adult; 6 months of uninterrupted experience in strength training	neuromuscular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-107frvnf	Effect of beetroot juice on the performance of cyclists	Recruiting	Intervention	2026-02-10	<NULL>	<NULL>	8852	The effect of beetroot juice on cardiorespiratory and neuromuscular responses in trained cyclists	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Male participants aged between 20 and 40 years. Volunteers must be active cyclists who perform training sessions at least three times per week, totaling a minimum of 8 hours of weekly cycling sessions. Additionally, they must have at least two years of practical experience in training and competitions within the modality. All participants must be free of pre-existing comorbidities and must sign the Informed Consent Form (ICF) prior to the performance of any study procedures.	Individuals who regularly use tobacco (smokers) or who have sustained any type of musculoskeletal injury within the 40 days prior to the start of testing. Additionally, participants presenting clinical contraindications for maximal physical exertion or those who fail to fully comply with the supplementation protocol and the established washout requirements will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-2n84wsc	Effect of beetroot juice on the performance of women who practice cycling	Not yet recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9103	Effects of beetroot juice concentrate supplementation on the performance of female cyclists in an endurance trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-27	Departamento de Ciências do Movimento Humano da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women aged between 18 and 60 years; cycling practitioners with a minimum of one year experience; training frequency of at least two to three times per week; signing of the Informed Consent Form	Presence of intellectual or physical disabilities; clinical, neuromotor, neurological, psychiatric or cognitive impairments; recent injury or in recovery period; musculoskeletal injuries; use of androgenic anabolic steroids; smoking; patients with known chronic degenerative pathologies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-7k79kd	Effect of betaine supplementation on the athlete&apos;s ability to perform multiple repetitions on the bench press	Data analysis completed	Intervention	2020-07-28	<NULL>	<NULL>	4062	Effect of betaine supplementation on athletes&apos; physical capacity	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-12-27	CAPES	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7k79kd	<NULL>	Men; Healthy; age between 18 and 30 years; strength training practitioners; no history of use of nutritional supplementation; no history of injury.	Perform training sessions 24 hours before the experimental protocol, present with late-onset muscle pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-6fsprpc	Effect of bicarbonate anesthesia on mandibular molars	Recruitment completed	Intervention	2022-06-28	<NULL>	<NULL>	5451	Anesthetic effect of 4% and 2% alkalized Articaine for infiltrative anesthesia in mandibular molars	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2021-08-01	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6fsprpc	<NULL>	Healthy individuals; Age 18 years or older; Previous experience of local anesthesia (have already taken it on another occasion); No history of complications resulting from local anesthesia; Lower molars on both sides healthy (absence of restorations); Responsible for the electrical stimulus “Pulp Tester”.	Pregnant women; lactating women; with systemic involvement that would contraindicate anesthesia; History of allergic reaction to any component of the anesthetic solutions used; Presence of an inflammatory condition in the region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-10556nyj	Effect of biking at different timings on physiological and blood variations	Recruitment completed	Intervention	2022-06-21	<NULL>	<NULL>	5436	Effect of Temporal Deception on the metabolism of semi-professional cyclists	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-05	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-10556nyj	<NULL>	Cyclists; minimum of 2 years of experience; training three times a week; 2 or more competitions in the last year.	Medications or nutritional supplements users; Injury in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-49w7xgy	Effect of Bixa orellana L. phytocomplex (Chronic®) supplementation in patients with fibromyalgia: a randomized, double-blind, placebo-controlled pilot study	Recruiting	Intervention	2024-09-02	<NULL>	<NULL>	7301	Efficacy and safety of Bixa orellana L. phytocomplex (Chronic®) supplementation in patients with fibromyalgia: a randomized, double-blind, placebo-controlled pilot study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-07-05	Hospital das Clinicas da Faculdade de Medicina da USP	Hospital das Clinicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-49w7xgy	<NULL>	Thirty women diagnosed with fibromyalgia, aged 18 to 60 years, who meet the American College of Rheumatology criteria for the diagnosis of fibromyalgia will be recruited. Participants will be selected from the fibromyalgia outpatient clinic at the Rheumatology Service of the Hospital das Clínicas, School of Medicine, University of Sao Paulo, a high-complexity, tertiary service of the Unified Health System.	Women with the following conditions will be excluded from the study: associated inflammatory rheumatic diseases; advanced chronic kidney disease (stages IV or V); diseases affecting locomotion and mobility, such as knee or hip osteoarthritis; severe psychiatric disorders that hinder proper understanding of the study and follow-up; pregnancy, use of oral anticoagulants (due to the risk of drug interactions); active neoplasia; and refusal to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-39jnyj	Effect of bleaching with activated carbon on enamel	Recruiting	Intervention	2020-09-21	<NULL>	<NULL>	4267	Effectiveness, sensitivity and action on the enamel surface of activated carbon as bleaching agent: clinical and in situ study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-39jnyj	<NULL>	Volunteers between 18 and 25 years old; both sexes; good oral and general health; vital teeth with color starting at A2; superior first molar with clinical crown greater than 5 mm, third molars extracted for orthodontic indication; vital	Have previous bleaching; smoker; tetracycline stains; fluorosis; hypoplasia; cracks; caries lesions; non carious lesions; periodontal disease; parafunctional habits; sensitivity; resin restorations in the anterior region; fixed or removable orthodontic appliance; third molars with morphological defects; cracks, fractures, caries lesions, non carious lesions and restorations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-6qhpvjz	Effect of Block age on Thoracic Transverse Plan in Cardiac Surgery	Recruitment completed	Intervention	2023-02-07	<NULL>	<NULL>	5883	Evaluation of the Blockage of the Transverse Muscle of the Chest Guided by Ultrasound in Cardiac Surgery: randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-12-01	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-6qhpvjz	<NULL>	Patients admitted to the universitario onofre lopes hospital to undergo non-coronary cardiac surgery with median sternotomy	Refusal of the patient;Patients under 18 years of age or older than 70 years;Ejection fraction &lt; 35%;Urgent cardiac surgery;Current or previous myocardial revascularization surgery;Patients with body weight &lt; 50 kg or BMI&gt;40kg/m2 ASA ≥ IV;Severe systemic disease (renal, hepatic, pulmonary or endocrine);Hematological disorders;Hemodynamic instability;Pregnancy;Patient with chronic pain, using analgesics;Psychiatric or cognitive disorders;Allergy to drugs used in research; Contraindication to regional blockades according to the American Society of Regional Anesthesia and Pain guideline	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-8bn3y2	Effect of Blocking a nerve in the neck and arm on inflammation in shoulder surgery. Comparative study	Data analysis completed	Intervention	2018-07-26	<NULL>	<NULL>	2060	Effect of Interscalene Block on the inflammatory response in Shoulder surgery. Comparative study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Instituto Nacional de Rehabilitación	Instituto Nacional de Rehabilitación	https://ensaiosclinicos.gov.br/rg/RBR-8bn3y2	<NULL>	"Patients scheduled for arthroscopic surgery of the shoulder; Patients of both genders; Patients from 35 to 70 years age
Patients with American Society Anesthesiologists (ASA) physical status classification I or II; Patients who agree to participate in the study; Patients with leukocyte count within normal (count among 4 x 103/mm3 and 11 x 103/mm3)"	Patients with obesity (body mass index higher 30 Kg/m2); Patients with malnutrition; diabetes mellitus; metabolic syndrome; pre-existing coagulopathy; acute or chronic focus of infection; congenital or acquired immunological disease; collagen disease; local or systemic inflammatory disease; endocrine disease; oncological disease; psychiatric illness; organ failure; chronic pain in another bodily region; use of steroids or immunomodulators; chronic use of non-steroidal anti-inflammatory drugs; chronic use of alpha2-adrenergic agonists; previous surgery of the same shoulder and airway difficulties.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-4w8v93	Effect of blood flow restriction exercise on osteopenic women	Recruitment completed	Intervention	2020-09-14	<NULL>	<NULL>	4246	Chronic effects of strength exercise with blood flow restriction on bone metabolism biomarkers, strength and quality of life in osteopenic women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Comunitária da Região de Chapecó	Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-4w8v93	<NULL>	Osteopenic Women	"Women under the age of 35 and over 99;
Men;
Recruits who have clinical restrictions for physical exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-3p4ddh5	Effect of blood orange juice intake on inflammatory response in overweight women.	Recruitment completed	Intervention	2021-03-04	<NULL>	<NULL>	4564	Chronic effect of blood orange juice intake on microRNA expression profile and inflammatory response in overweight women.	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2017-08-18	Food Research Center São Paulo State Research Foundation (FAPESP)	Faculdade de Saúde Pública (USP)	https://ensaiosclinicos.gov.br/rg/RBR-3p4ddh5	<NULL>	women between 18 and 40 years old; BMI between twenty-five and twenty-nine and nine kg/m² and be willing to adhere to the study protocol and to sign the informed consent form.	men; under 18 years old or over 40 years old; BMI less than twenty-five kg/m² or greater than twenty-nine and nine kg/m²; be an athlete; diagnosis of diabetes mellitus; use medication to control inflammation, plasma lipid profile (statins, fibrates (fenofibrate), Omacor, etc.) or systemic blood pressure (ACE inhibitors, angiotensin 2 receptor blockers, calcium channel blockers, ?-inhibitors and diuretics); make use of vitamin supplements, probiotics, prebiotics, symbiotics, antibiotics or any other medicine that may interfere with the intestinal microbiota; have a habit of frequently consuming grape juice; having had alcohol in the 7 days prior to the study; be a smoker; have any chronic gastrointestinal disease (eg inflammatory bowel disease, celiac disease, cancer); being pregnant and / or participating in another study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-7hrnhg	Effect of body weight-based Strength Training in hypertensive elderly	Recruitment completed	Intervention	2019-11-25	<NULL>	<NULL>	3228	Acute effect of a strength-based Alternative Training session on Blood Pressure in hypertensive elderly: a randomized crossover trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7hrnhg	<NULL>	Regularly participate in the PROCOR extension program for less than six months; have medical authorization for physical exercise; be 60 years old or older; have a diagnosis of hypertension or have controlled blood pressure with medication.	Osteomioarticular limitations for the execution of strength exercises; episode of acute myocardial infarction or have had cardiac surgery for less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-6zf66bj	Effect of bodyweight training on Frailty in seniors with High blood pressure	Recruitment completed	Intervention	2026-01-08	<NULL>	<NULL>	8717	Effect of Bodyweight Interval Training on Frailty Status in Hypertensive Elderly: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Age 60 years or older; Be of any gender; Be recruited from the cardiogeriatrics sector of the Dante Pazzanese Institute of Cardiology; Be classified as frail	Diagnosis of dementia; Presence of psychiatric disorders; Presence of mental disability; History of stroke with severe impairment; Presence of physical impairment that prevents mobility for performing the exercises	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-868rxjt	Effect of bonding on the performance of veneers	Not yet recruiting	Intervention	2024-09-17	<NULL>	<NULL>	7350	Effect of the kind of cement on the performance composite veneer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-868rxjt	<NULL>	An upper or lower anterior tooth (incisor or canine) requiring indirect veneer restoration; presence of antagonists and neighboring teeth making contact, good oral health; age between 18 and 70 years; both genders	Extensive coronary destruction that contraindicates a veneer restoration; teeth with spontaneous or constant pain indicative of irreversible pulpitis; presence of periapical lesions; severe systemic disease; allergy to restorative materials; periodontal disease; bruxism; harmful parafunctional habits; history of hypersensitivity in the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-6jhqzd	Effect of Botox Treatment on the quality of life of patients with teeth grinding and pain in the Temporomandibular Joint	Recruitment completed	Intervention	2018-08-10	<NULL>	<NULL>	2111	Effect of Botulinum Toxin Treatment on the quality of life of patients with bruxism and pain in temporomandibular joint	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de Uberlândia - UFU	Universidade Federal de Uberlândia - UFU	https://ensaiosclinicos.gov.br/rg/RBR-6jhqzd	<NULL>	Pacients with bruxism.Agree to participate and sign the informed consent form (TCLE)	"Existence of active psychosis, another active or cognitive impairment, existence of serious co-morbid conditions, individuals
who have had exposure to any botulinum toxin preparation in the last 6 months, participation in another experimental therapeutic protocol, any medical condition in which the administration of the toxin
botulinum toxin is contraindicated, including myasthenia gravis, amyotrophic lateral sclerosis and other
acute history of dysphagia, history of botulism, a condition or the situation in which the investigators
confusion in the subject&apos;s ability to participate in the study, inability to understand and sign informed consent, pregnancy, do not meet inclusion criteria and individuals who are hypersensitive to any component of the research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-7s8qnjj	Effect of Botulinum Toxin Type A on neuromuscular adaptations in individuals with muscle stiffness after Stroke	Not yet recruiting	Intervention	2022-04-27	<NULL>	<NULL>	5364	Effect of Botulinum Toxin Type A on neuromuscular plasticity in individuals with spasticity post-Stroke	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2022-05-09	Universidade Federal do Rio Grande do Sul -UFRGS	Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul- PUCRS	https://ensaiosclinicos.gov.br/rg/RBR-7s8qnjj	<NULL>	individuals over 18 years of age; of both sexes; who have suffered a stroke; incident time greater than 12 months; ability to walk with or without crutches/canes; presence of spasticity in the ankle plantarflexor muscles	Individuals in rehabilitation or any treatment of a kinetic-functional nature; individuals who have already applied botulinum toxin for less than six months; history of surgical procedure or use of orthopedic prosthesis; presence of neurological disease or dementia; cognitive alteration that prevents understanding of the research; presence of joint or musculoskeletal injury of an inflammatory nature	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-57gn649	Effect of Brain Light Therapy on Gait and Balance in People with Parkinson’s Disease	Recruiting	Intervention	2025-09-29	<NULL>	<NULL>	8322	Effect of transcranial photobiomodulation on gait and postural control in people with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Pedro Paulo Gutierrez	Universidade Estadual Paulista (UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-57gn649	<NULL>	Participants with Parkinson’s disease will be recruited from the Physical Activity Program for Patients with Parkinson’s Disease and the local community, based on the following inclusion criteria: (i) a diagnosis of idiopathic Parkinson’s disease made by a neurologist, according to the London Brain Bank criteria, and (ii) classification between stages 1 and 3 on the Hoehn and Yahr scale	Exclusion criteria include: (i) a history of orthopedic and/or visual impairments that prevent compliance with the experimental protocol; (ii) uncontrolled diseases that may affect peripheral sensory functions (e.g., diabetes); (iii) conditions that pose a risk for Transcranial Photobiomodulation, such as structural brain disease, epilepsy, or the use of potentially photosensitizing medications (e.g., imipramine, phenothiazines, lithium, chloroquine, hydrochlorothiazide, tetracycline); (iv) clinical signs of dementia, defined as a Mini-Mental State Examination score below 20; and (v) failure to complete the 18 required modulation/evaluation sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-8f5w2q	Effect of brain stimulation by electric current on eating behavior in overweight people	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1767	Effect of transcranial direct current stimulation (tDCS) on eating behavior in participants with excess of	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-06	Faculdade de Ciências da Saúde do Trairi - FACISA	Faculdade de Ciências da Saúde do Trairi - FACISA	https://ensaiosclinicos.gov.br/rg/RBR-8f5w2q	<NULL>	Age between 19 and 50 years; body mass index equal to or greater than 25; abdominal circumference greater than 94 centimeters for men and greater than 80 centimeters for women	Pregnant and breastfeeding women; women in menopause; user of illicit drug, use of psychotropic medication and for weight loss; previous or current history of eating disorder, psychiatric; suffered a stroke, head trauma, neurosurgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-76ccw9	Effect of brain stimulation on the regulation of emotions	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3537	Effects of neurostimulation on emotional regulation: understanding the role of the pre-frontal cortex	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-76ccw9	<NULL>	University students, 18 to 40 years old, without psychiatric disorder, no history of brain surgery or brain tumor, contraindications for tDCS, no such as intracranial metal implantation.	People with signs of psychiatric disorder; under 18 and over 40 years; history of brain tumor or implant or brain surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-289hz3v	Effect of Brazil nut consumption as a source of selenium on the production of free radicals, inflammation and its relationship with a genetic polymorphism of glutathione peroxidase 1 in women with rheumatoid arthritis.	Data analysis completed	Intervention	2022-06-28	<NULL>	<NULL>	5453	Effect of Brazil nut supplementation (Bertholletia excelsa H.B.K.) as a source of selenium on oxidative stress markers, inflammatory cytokines, and their relationship with Pro198Leu polymorphism in the glutathione peroxidase 1 gene in patients with rheumatoid arthritis.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-07	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-289hz3v	<NULL>	Patients diagnosed with rheumatoid arthritis (criteria established by the American College of Rheumatology); pharmacological stability of at least 3 months; Healthy individuals with no diagnosis of rheumatologic and autoimmune diseases.	Not pregnant; not be in lactating period; not participating in another clinical trial; not using vitamin-mineral supplements (except calcium and vitamin D); not smoking; not abusing alcohol; not have diagnostic of cancer, thyroid, kidney diseases; not consuming Brazil nuts regularly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-7rwgzt	Effect of Brazil Nut consumption on mineral Selenium compounds in the continuous use of cholesterol-lowering drugs	Data analysis completed	Intervention	2017-08-07	<NULL>	<NULL>	3262	Effect of Brazil Nut (Bertholletia excelsa H.B.K.) consumption on Selenocomposites in the chronic use of Statins	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-18	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7rwgzt	<NULL>	Adults subjects of both sexes; in chronic use of Statins; with muscle disorders in the case of individuals in the study group; no muscle disorders in the case of individuals in control group	Presence of serious cardiac complications or other diseases such as thyroid; hematological; congenital; autoimmune; liver disease; renal failure; cancer; associated infections; osteoporosis; postoperative; antibiotics and vitamin and mineral supplements; food allergy to oilseed; current alcoholism and smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-54qqz5	Effect of Brazil nut supplementation on the maternal diet under the nutritional profile of human milk	Recruitment completed	Intervention	2019-03-28	<NULL>	<NULL>	2554	Effect of Brazil nut (Bertholletia excelsa) supplementation on the maternal diet under the nutritional profile of human milk	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Departamento de Tecnologia de Alimentos - UFV	Departamento de Tecnologia de Alimentos - UFV	https://ensaiosclinicos.gov.br/rg/RBR-54qqz5	<NULL>	To be included in the research, breastfeeding women should: residing in the municipality of Viçosa, MG; have born newborn term, ie, gestational age between 37 and 42 weeks, healthy, and weight appropriate for gestational age; only breastfeeding; they are producing enough milk and willing to donate the samples for research; Being in the age group between 18 and 40 years; accept participation and sign the informed consent form	Breastfeeding women who interrupt exclusive breastfeeding during the period of study; lack the evaluation; stop collecting the milk sample or present at any time allergy or intolerance to Brazil nuts will be excluded from the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-6pvj72b	Effect of Brazilian foods on glycemia	Recruitment completed	Intervention	2023-12-07	<NULL>	<NULL>	6638	Glycemic response of Brazilian foods	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-07	Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pvj72b	<NULL>	Age between 18 and 45 years old; both genders; must be in good health; according to report on the absence of diabetes; kidney and gastrointestinal diseases; hyperthyroidism; underweight or overweight/obesity and report of family history of diabetes; volunteer women cannot be pregnant; breastfeeding or report hormone therapy; and all individuals must be exempt from the use of any type of medication that may affect the digestion and absorption of food (antibiotics; medication for diarrhea; and intestinal constipation) during the study period	Overweight/obese individuals (BMI≥25 kg/m2); and underweight (BMI≤18.6 kg/m2) according to criteria of the World Health Organization (WHO, 1997); previous diagnosis of diabetes mellitus or carrier family members; with possible eating disorders (anorexia; bulimia) or intestinal problems (chronic diarrhea; irritable bowel syndrome; Crohn&apos;s disease; ulcerative colitis); reports of illness; pregnancy; treatment of any kind	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-69zhsxr	"Effect of breathing exercises in patients with pulmonary diseases due to
non-tuberculous mycobacteria"	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4971	"Effect of respiratory physiotherapy in patients with pulmonary diseases due to
non-tuberculous mycobacteria"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	UFCSPA - Universidade de Ciências da Saúde de Porto Alegre	Hospital Sanatório Partenon - Secretaria Estadual da Saúde do RS	https://ensaiosclinicos.gov.br/rg/RBR-69zhsxr	<NULL>	Patients at the Tuberculosis / MNT Outpatient Clinic of the Hospital Sanatório Partenon of the State Health Department; older than 18 years; who are able to carry out the exercises alone; using smartphones with Internet access	Recent history of hemoptysis; undergoing regular physical therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-8d4vkr	Effect of brushing associated with oral irrigation on tissue around implants and mandibular prosthesis hygiene	Recruitment completed	Intervention	2017-08-18	<NULL>	<NULL>	1339	Effectiveness of brushing associated with oral irrigation in maintenance of peri-implant tissues and overdentures – randomized clinical trial.	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-12-09	Faculdade de Odontologia de Ribeirão Preto - USP	Faculdade de Odontologia de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-8d4vkr	<NULL>	Adult, healthy and complete edentulous subjects, both genders, use of maxillary conventional complete dentures and mandibular overdentures retained by 2 to 4 implants, and with an O-ring-retained system; clinically satisfactory prostheses; implants and overdentures in function for at least 6 months, and the retention rings, from 1-6 months.	Uncontrolled diabetic patients; immunossupressed patients; use of antibiotics, antifungals or corticosteroids in the last 3 months; current use of anticoagulants, anticonvulsants, and immunossupressants; relined, repaired or fractured prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-6vnrmfn	Effect of Buriti supplementation compared to whey protein in healthy young adults undergoing physical exercise	Not yet recruiting	Intervention	2024-12-08	<NULL>	<NULL>	7579	Effect of Hyperproteic Supplementation Based on Buriti (Mauritia Flexuosa) Versus Whey Protein in Healthy Young Adults Undergoing Physical Exercise: A Randomized, Blind, Controlled Pilot Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-6vnrmfn	<NULL>	The study will enroll men and women; aged between 18 and 35 years; who are apparently healthy according to the criteria of the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+); and classified as insufficiently active or sedentary based on the International Physical Activity Questionnaire (IPAQ)	Individuals with musculoskeletal injuries that limit the capacity for moderate and vigorous exercise during the study period; neoplastic, hepatic, renal, or cardiovascular disorders; malabsorption disorders; those consuming anti-inflammatory drugs, analgesics, antibiotics, or vitamin and mineral supplements during the study period; individuals on medications affecting metabolic profile; and vegetarians will be excluded. Additional exclusion criteria will include pregnancy and breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-3cf3zj3	Effect of Buzzy® cooling and vibration on pain perception and success of peripheral venipuncture in hospitalized children clinical trial	Recruiting	Intervention	2024-06-13	<NULL>	<NULL>	7066	Effect of vibration and cryotherapy with Buzzy® on pain perception and success of peripheral intravenous catheterization in hospitalized children parallel and open clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de São Paulo	Laboratório de Estudos e Pesquisas em Inovação e Segurança no Cuidado em Saúde - Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-3cf3zj3	<NULL>	Age between 4 to 12 years incomplete; elective indication for peripheral intravenous catheterization with catheter over needle; peripheral intravenous catheterization performed regardless of shift; stable clinical or surgical conditions; first peripheral intravenous catheterization performed at the hospital	Being hospitalized in wards that require the use of some specific contact or respiratory precautionary measure; be in the preoperative period that requires peripheral intravenous catheterization immediately before being transferred to the operating room; have a medical request to collect a blood sample for laboratory tests during the peripheral intravenous catheterization; having a skin lesion near the catheter insertion site, which will prevent Buzzy from positioning; Having previous nerve damage in areas close to the region to be catheterized or any report of limited sensitivity in the extremity listed for insertion of the intravenous catheter; Have peripheral neuropathy; being diagnosed with a disease associated with hypersensitivity to cold such as Raynaud&apos;s Syndrome or sickle cell disease; having used topical, enteral or parenteral analgesics between four to eight hours before catheterization; presence of cognitive impairment or inability to verbally report pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-9jk5xn	Effect of Caffeine Administration on Responses to Physical Exercise	Recruitment completed	Intervention	2018-01-15	<NULL>	<NULL>	1570	Effect of Mouthwash with Nutritional Products containing Caffeine on the Immunometabolic Profile and Physical Performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9jk5xn	<NULL>	"First stage: healthy adult men; healthy adult women; have been training triathlon for over a year; aerobic capacity greater than 60% of VO2max; have a fixed routine of intense and moderate exercise (ranging from 4-6 times per week with a duration of 60-240 min per training day).

Second stage: healthy adult males; CrossFit® practitioners for at least one year."	First and second steps: use of anabolic steroids; use of dietary supplements; use of immunosuppressive drugs; use of antibiotics; use of stereochemical and non-stereochemical anti-inflammatories; in a food restriction program; carriers of immune diseases; hepatic diseases; renal diseases; pneumopathy; cardiopathies; chronic alcoholics; smokers; injured individuals; individuals in the inflammatory process.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-4x9j9hq	Effect of Caffeine on respiratory muscle in premature newborns	Data analysis completed	Observational	2025-01-30	<NULL>	<NULL>	7699	Effect of Caffeine Citrate on diaphragmatic electrical activity in pre-term newborns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-07-19	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-4x9j9hq	<NULL>	Newborns; of both genders; preterm newborns with gestational age equal to or less than 28 weeks; newborns between 28 and 32 weeks of gestational age under  invasive or non-invasive ventilatory support; newborns with clinical diagnosis of apnea with gestacional age less than 37 weeks	Patients with major congenital malformations; anomalies of the upper digestive tract; primary neurological or drug-related abnormalities; newborns under high-frequency mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-97ndkq7	Effect of caffeine on weight and physical performance	Data analysis completed	Intervention	2022-07-25	<NULL>	<NULL>	5507	Effect of mouthwash with nutritional products containing caffeine on the immunometabolic profile and physical performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-97ndkq7	<NULL>	Man; physically active; experience with resistance training for at least 2 months; equal or greater than 18 years; availability of time and transportation	Smoker; Illnesses; Inflammatory process; Injury to lower or upper limbs; caffeine allergy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-2yyd8jb	Effect of Caffeine or Transcranial Direct Current Stimulation on attack decision-making in trained beach volleyball players after prolonged cognitive effort by use of social media: a study crossover randomized	Recruitment completed	Intervention	2024-01-22	<NULL>	<NULL>	6757	Caffeine and Transcranial Direct Current Stimulation: effect on the performance of mentally fatigued young athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Yago Pessoa da Costa	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2yyd8jb	<NULL>	Training beach volleyball for at least two years; compete on the regional circuit; have competed in the previous year on the national circuit; be at least 22 years old; male	Withdraw from the research for any reason; sustain an injury during the research; fail to comply with recommended procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-52twgg	Effect of caffeine supplementation on physical performance and oxidative stress during high-intensity exercises	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3767	Effect of caffeine supplementation at physical performance and balance redox during a high-intensity interval training (HIIT) protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-20	Universidade Federal do Paraná	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-52twgg	<NULL>	Recreationally active adults; practicing strength training at least 150 minutes a week; male	Habitual caffeine users; individuals not used to strength training; be participating in another study during the analyzes; present an injury or physical impairment that prevented the tests from being performed; cardiovascular diseases; smoker; use of other supplements during testing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-4t2hqqt	Effect of Calcium Hypochlorite in Endodontic Treatment	Data analysis completed	Intervention	2024-06-03	<NULL>	<NULL>	7040	Effect of Calcium Hypochlorite as an irrigating solution in Endodontic Treatment: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4t2hqqt	<NULL>	Healthy patients; both genders; age between 18 and 60 years;need for endodontic treatment; asymptomatic	Use of antibiotics, anti-inflammatories or analgesics for at least 7 days before the procedures; preoperative pain; teeth with incompletely formed apices; calcified root canals; periodontal probing greater than 3 mm; persistent exudate at the time of filling; immunosuppression or immunocompromised	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-7q2n33	Effect of calcium intake on body weight and body fat in overweight individuals	Data analysis completed	Intervention	2016-03-01	<NULL>	<NULL>	725	Effect of calcium on weight and body composition in overweight individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Federal de Viçosa - UFV	Fundação do Amparo à Pesquisa do Estado de Minas Gerais - FAPEMIG	https://ensaiosclinicos.gov.br/rg/RBR-7q2n33	<NULL>	Healthy overweight or obese women; calcium intake less than 800 mg/day; physical activity level of mild to moderate; aged between 19 and 40 years; non smokers; restriction and disinhibition level less than 14.	Use of calcium or vitamin D supplements or any medication that affects the metabolism of calcium; medications or herbs for weight reduction; adoption of diets for weight reduction; use of drugs for estrogen replacement; weight gain or loss more tran 3kg in the last three months; recent changes in physical activity level; aversion or intolerance to foods used in the study; consumption of alcohol higher than 2 servings a day; presence of eating disorders, endocrine pathology, renal disfunction, hepatic disease or malabsorption syndrome; caffeine intake more than 350mg/day; pregnance; lactance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-242vw9	Effect of calf muscle strenght control training on balance of elderly women	Recruitment completed	Intervention	2017-06-29	<NULL>	<NULL>	1273	Effect of stability strenght training of plantar flexor muscles in postural sway of elderly women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-242vw9	<NULL>	Feminine gender; Age greater than 60 years; With no history of lower limb injury in the last six months	Musculoskeletal lesion in the lower limbs in the last six months; Vestibulopathy, neuropathy, being in the acute phase of some treatment for lower limbs, neurological problems that interfere in the capacity to carry out the study training and assessment protocols	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-4stgs8	Effect of cannabidiol in the treatment of crack dependence	Recruitment completed	Intervention	2019-06-07	<NULL>	<NULL>	4745	Study of the feasibility, safety and short-term results of the therapeutic use of cannabidiol (CBD) in the treatment of cocaine dependence in the form of crack	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2019-08-05	Universidade de Brasília, Faculdade de Ceilândia (UNB/FCE)	Universidade de Brasília, Faculdade de Ceilândia (UNB/FCE)	https://ensaiosclinicos.gov.br/rg/RBR-4stgs8	<NULL>	Volunteers of both sexes; age between 18 and 65 years; on regular crack use in the last year on a daily basis or at least 20 times in the last 30 days; under treatment at the Center for Psychosocial Care alcohol and drugs (CAPS AD) of Ceilândia or indicated by persons under treatment in this service.	Presence of severe psychiatric comorbidities that impair the viability or safety of the study intervention; use of other medications directed to the treatment of severe or unstable chronic conditions (such as renal, cardiac, hepatic or neurological disease) and / or psychiatric comorbidities; hypersensitivity to cannabinoids or any of the excipients of the investigational medicinal products; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-8d9hxj	Effect of carbohydrate-rich solutions on gastric emptying in children	Data analysis completed	Intervention	2019-11-13	<NULL>	<NULL>	4828	"Mother project: &quot;Effect of administering different carbohydrate-rich solutions on gastric emptying in pediatric patients: Randomized controlled trial&quot;

Subproject I: &quot;Ultrasound evaluation of gastric volume in children undergoing upper digestive endoscopy after ingestion of different carbohydrate-enriched solutions compared with fasting pediatric patients: a randomized controlled trial&quot;

Subproject II: &quot;Effects of the administration of different carbohydrate-rich solutions on ga"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-29	Faculdade de Medicina de Botucatu da Universidade Estadual Júlio de Mesquita Filho	Faculdade de Medicina de Botucatu da Universidade Estadual Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-8d9hxj	<NULL>	Age between 3 and 15 years; elective upper digestive endoscopy; written authorization from parents or legal representatives through the Free and Informed Consent Form, in the case of children aged 3 to 12 years; over 12 years old, authorization by an Informed Consent Form.	Use of nasoenteric tube; Unstable clinical situation; Presence of encephalopathies; History of gastroparesis; History of recent upper gastrointestinal bleeding (more than 1 month); Previous surgery of distal stomach or esophagus; Vomiting after solution consumption; Children whose parents or legal guardians do not agree to participate; Non-aspirable intra-gastric content	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-4j2g5qj	Effect of cardiac physiotherapy on the quality of life and frailty profile of women with breast cancer undergoing chemotherapy	Terminated	Intervention	2024-08-16	<NULL>	<NULL>	7229	Effect of cardiac rehabilitation on the quality of life and frailty profile of breast cancer patients undergoing chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-31	Universidade do Planalto Catarinense	Instituto do Coração de Lages	https://ensaiosclinicos.gov.br/rg/RBR-4j2g5qj	<NULL>	Women over 18 years old diagnosed with breast cancer, ductal carcinoma in situ or stages I to III, undergoing chemotherapy treatment. Agree to participate in the study by signing the free and informed consent form	Patients with self-reported physical or mental inability (assessed by the Mini-mental State) to perform the proposed exercises. Unavailability to participate in all stages of the research. Do not attend 75% of the proposed exercise program. Have had unstable angina or acute myocardial infarction in the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-4vzrfyf	Effect of cardiopulmonary rehabilitation protocol on functionality, strength of breathing and body muscles and quality of life in COVID-19 patients	Recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5168	Effect of cardiopulmonary rehabilitation protocol on functionality, respiratory muscle e strength, perioheral and quality of life in patients recovered from COVID-19: a controlled and randomizes clinical study	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2021-10-01	Hospital Otávio de Freitas	Hospital Otávio de Freitas	https://ensaiosclinicos.gov.br/rg/RBR-4vzrfyf	<NULL>	Patients with at least six weeks after the clinical diagnosis of COVID-19, admitted and participating in the post COVID-19 cardiopulmonary rehabilitation protocol;  Over 18 years of age; Both sexes; Presence of symptoms such as dyspnea, fatigue and functional impairment after recovery from COVID-19	Active stage of the disease; Inability to understand and execute commands; Osteoarticular and/or muscle deficit that does not allow walking or with limits to the implementation of the established protocol; Patient diagnosed with lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Asthma, Cystic Fibrosis, Post Tuberculosis Pulmonary Disease, among others; Patients who have absolute contraindications to perform the six-minute walk test (6MWT) which include the presence of unstable angina, uncontrolled systemic arterial hypertension, recent pulmonary embolism and heart attack that occurred in the month prior to the exam; Patients who drop out of treatment or have no 03 missing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-95jnqp	Effect of carvedilol medication and vitamins E and C in patients with Chagas&apos; disease.	recruitment completed	Intervention	2012-01-04	<NULL>	<NULL>	53	Effect of carvedilol and antioxidant vitamins (E and C) in patients with chronic Chagas cardiopathy.	<NULL>	4, non-randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Federal do Rio de Janeiro	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-95jnqp	<NULL>	We included only patients who had previously studied the oxidative stress in the year 2003 onwards, aged between 21 and 70 years active and regularly monitored in ambulatory Chagas Service of Cardiology HUCFF diagnosed with Chagas disease, and that maintained the same eating habits. We only included patients with Chagas disease without other chronic diseases, apart from an endemic area for over 20 years.	"Patients were excluded from the study if they had any of the following characteristics:
Patients who have not completed the initial protocol of admission;
Patients previously treated with carvedilol;
Patients who were treated specifically for Chagas&apos; disease;
Patients with clinical or laboratory findings suggestive of severe liver or kidney disease or thyroid dysfunction;
Patients with a history of chronic obstructive pulmonary disease (all
forms), chronic alcoholism or smoking;
Patients with anemia, obesity, hypertensive heart disease, diabetes mellitus or other systemic disease;
Patients with signs, symptoms or a history of ischemic heart disease
confirmed after investigation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-3zb24z	Effect of cashew meal in the fight against child malnutrition	Recruitment completed	Intervention	2018-06-15	<NULL>	<NULL>	1901	Effect of cashew meal in the nutritional state of children with malnutrition	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal do Maranhão - UFMA	Universidade Federal do Maranhão - UFMA	https://ensaiosclinicos.gov.br/rg/RBR-3zb24z	<NULL>	Term birth. Age between 2 and 5 years. Both sexes. Malnutrition for at least 60 days. Preserved renal and hepatic function. Do not have allergy to products coming from cashew nuts. Mentally capable legal person	Severe malnutrition with z score less than -3. User of psychotropic, antimicrobial or antineoplastic. Carrier of syndromes. Chronic disease. Having started intervention for recovery of nutritional status.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-8xzkyp2	Effect of cashew nut and its oil on weight loss, blood pressure, sugar and fat in the blood, and bowel improvement in individuals at excess of weight	Recruitment completed	Intervention	2021-11-25	<NULL>	<NULL>	6492	Effect of the cashew nut and its oil on cardiometabolic, genetic and intestinal microbiota risk markers in  individuals at excess of weight	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-03	Universidade Federal de Viçosa	Embrapa Agroindústria Tropical	https://ensaiosclinicos.gov.br/rg/RBR-8xzkyp2	<NULL>	Men and women between 20 and 55 years old; Excess weight (≥ 27 kg/m²), high waist circumference (≥ 80 cm for women; ≥ 90 cm for men) and excess body fat (&gt; 30% for women and &gt; 20% for men) associated with another component of the Metabolic Syndrome: triglycerides ≥150 mg/dL; blood pressure ≥ 130/85 mmHg) or fasting glucose ≥100 mg/dL or; Obesity (BMI ≥ 30 kg/m²) regardless of the presence of other components of the Metabolic Syndrome.	Pregnant, lactating or menopausal women; Athletes; Smokers; Vegans; Shift workers; With a history of HIV, digestive, hepatic, renal, cardiovascular, thyroid, cancer, inflammatory diseases or eating disorders; Who have a history of drug and/or alcohol abuse; Aversion or allergy to nuts; Who has had an infection in the last month; Consume more than 30 g/day of nuts; Make use of certain medications such as anti-inflammatory drugs, corticoids and antibiotics; Have problems that can interfere with chewing; Weight instability (5% of usual weight) in the last 3 months; Alcohol consumption &gt; 21 units (≈168g) per week; Consumption of vitamin, mineral and omega 3 supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-92v86nn	Effect of CBD and THC substances present in the cannabis plant as maintenance therapy for parkinson&apos;s disease	Recruitment completed	Intervention	2025-02-17	<NULL>	<NULL>	7753	Effect of THC and CBD cannabinoids combined as maintenance therapy for parkinson&apos;s disease: an open-label exploratory clinical trial (cpf study)	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2024-01-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-92v86nn	<NULL>	Having completed the double-blind phase of the study without interruptions; having not presented serious adverse effects in the double-blind phase; signing the informed consent form; age 50 or older; male or female	Medical decision that participation in the study is not in the best interest of the patient; presence of any condition that does not allow the protocol to be followed safely, such as serious adverse effects	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-4fd8f8h	Effect of cerebral electrical stimulation combined with physical exercise on pain reduction and functional improvement in individuals with knee osteoarthritis	Recruitment completed	Intervention	2025-09-18	<NULL>	<NULL>	8289	Effect of Transcranial Direct Current Stimulation combined with Lower Limb Muscle Strengthening Exercises on pain and functionality in patients with knee Osteoarthritis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4fd8f8h	<NULL>	Male and female participants; age between 50 and 75 years; symptomatic knee osteoarthritis for at least 3 months; pain score greater than 3 on the 0–10 Numeric Rating Scale (NRS); Kellgren–Lawrence classification greater than grade 1	History of cancer; patients with type I diabetes; with uncontrolled arterial hypertension; with cardiac pacemaker; presenting neurological deficits; with orthopedic surgery in the lower limbs; with body mass index above 40 kg/m²; with symptomatic hip osteoarthritis; presenting cognitive impairment; with history of brain surgery; seizure; stroke or intracranial metal implantation; who underwent craniectomy at the site of transcranial direct current stimulation application; and decompensated ventricular shunt	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-88tgky	Effect of changing physical education lessons on  seating time and cognitive function	Recruitment completed	Intervention	2018-08-21	<NULL>	<NULL>	3478	Intervention in physical education classes to reduce sedentary behavior and improve cognitive function	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Fundação Universidade de Pernambuco	Escola Superior de Educação Física - Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-88tgky	<NULL>	"Adolescents enrolled in the first year in full-time public high schools;
Adolescents who are students at the Vale do Capibaribe Regional Educational Administration in the state of Pernambuco."	Physical or mental disabilities; Adolescents enrolled in schools that do not implement the intervention protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-4zvj6m3	Effect of chemical activation on pain after root canal treatment in young teeth	Recruiting	Intervention	2023-02-12	<NULL>	<NULL>	5900	Effect of irrigant attitude on postoperative pain in regenerative endodontics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Kely Firmino Bruno	União Sul-Americana de Educação	https://ensaiosclinicos.gov.br/rg/RBR-4zvj6m3	<NULL>	Female or male patients, aged 7-11 years, with necrotic anterior teeth with incomplete root formation and foraminal opening greater than 1.0 mm.	Patients with teeth with complete root formation, severe periodontal disease, calcified canals, with root resorption or even those with preoperative symptoms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-7scgp3h	Effect of chemical agents containing green tea and hyaluronic acid in controlling inflammation and bacterial plaque around teeth and implants.	Recruiting	Intervention	2021-10-11	<NULL>	<NULL>	4965	Effect of chemical agents containing green tea and hyaluronic acid, in dentifrice and mouthwash formulations, on periodontal and peri-implant clinical parameters. A Randomized Controlled clinical trials.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal de Uberlândia	New Detal Care LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7scgp3h	<NULL>	Patients with dental implant in partial or single rehabilitation with permanent dentures installed for at least 6 months; age group from 18 to 60 years old; systemically healthy	Smokers; uncontrolled diabetics; history of radiotherapy or chemotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-106z4g6c	Effect of chemicals containing Green Tea extract and Hyaluronic Acid on toothpastes and mouthwashes on the clinical and microbiological aspects of people using orthodontic appliances.	Recruitment completed	Intervention	2025-11-07	<NULL>	<NULL>	8489	Effect of chemical agents containing Green Tea extract and Hyaluronic Acid, in toothpaste and rinse formulations, on clinical and microbiological parameters of individuals with orthodontic appliances	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Individuals between twelve and thirty years of age; both genders; undergoing treatment with fixed orthodontic appliances in orthodontics specialization clinics at the Faculty of Dentistry of Ribeirão Preto; having a case of generalized gingivitis	Presenting systemic compromise; smoking; using drugs or controlled medication; having used mouthwashes with antimicrobial solutions for up to three months before the start of the research; using antibiotics for up to six months before the start of the research; not having used anti-inflammatory drugs in the seven days preceding the start of the research or using them during the research; patients who had undergone dental cleaning in the last six months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:05
RBR-2m6qx2r	Effect of chemotherapy on muscle tissue membrane integrity measured by phase angle in women with breast cancer	Recruitment completed	Observational	2023-01-02	<NULL>	<NULL>	5797	Effect of chemotherapy on anthropometric indicators, physical activity level, cardiovascular parameters in women with breast cancer	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-01-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2m6qx2r	<NULL>	Age over 18 years, diagnosis of breast cancer, neoadjuvant or adjuvant chemotherapy in their therapeutic protocol.	Participants with a previous diagnosis of chronic obstructive pulmonary disease, heart failure, or infectious diseases were excluded from the study. Additionally, volunteers who did not complete the assessment protocol, were unable to return for reassessment or did not carry out the therapeutic protocol prescribed during chemotherapy were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-9nt4gj	Effect of chest compression techniques on the diaphragm of healthy children from zero to two years	Data analysis completed	Intervention	2020-09-01	<NULL>	<NULL>	4198	Effect of different chest compression techniques on the diaphragm in healthy infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-18	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9nt4gj	<NULL>	The study included 22 healthy infants born at term (37 to 41 weeks) of both sexes, with at least 72 hours of life, this time was used respecting the safety criteria recommended by the I Brazilian Recommendation of Respiratory Therapy in Unit Pediatric and Neonatal Intensive Care	Infants born preterm, with congenital syndromes, upper or pulmonary airway malformations and central nervous system malformations, grade III or IV perintraventricular hemorrhage, peripheral nervous system injuries that interfere with the movement of the chest and the maintenance of the chest were excluded. airway opening, progressive neuromuscular disease, severe heart disease, congenital infectious disease, gastroesophageal reflux disease, chest or recent face trauma, respiratory disease with or without secretion up to two weeks prior to evaluation and incessant crying.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-8s9y2q	Effect of chest tube insertion site on pulmonary function in patients undergoing cardiac surgery	Data analysis completed	Intervention	2020-01-20	<NULL>	<NULL>	3380	Effect of chest tube insertion site on ventilatory function in patients undergoing elective myocardial revascularization surgery: a clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2014-07-31	sandra simon	Fundação Universitária de Cardiologia do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8s9y2q	<NULL>	Patients aged 40 to 80 years; indication for myocardial revascularization surgery with left internal thoracic artery graft and associated pleurotomy	Severe neuropsychiatric deficit; requiring other parallel surgical interventions; with no indication for pleurotomy; symptomatic abdominal hernias; previous diagnosis of stroke or any other conditions that prevented the performance of the manovacuometer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-26kgx5	Effect of chromium consumption in HIV patients with abnormal distribution of body fat	Recruitment completed	Intervention	2017-09-19	<NULL>	<NULL>	1384	Effect of chromium supplementation in HIV patients with lipodystrophy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-25	Faculdade de Medicina de Ribeirão Preto USP	Faculdade de Medicina de Ribeirão Preto USP	https://ensaiosclinicos.gov.br/rg/RBR-26kgx5	<NULL>	Men; adult; HIV-positive; ART for at least 6 months; with lipodystrophy.	Previous thyroidectomy or thyroid dysfunction; in use of glucocorticoids at the last year; with signs or symptoms of opportunistic infections; hepatic dysfunction; renal dysfunction; using insulin or hypoglycemic; taking vitamin and or mineral supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-3pdqt5	Effect of cinnamon intake on cardiovascular risk factors in elderly	Recruitment completed	Intervention	2016-08-08	<NULL>	<NULL>	3321	Effect of cinnamon (Cinnamomum sp) intake on metabolic syndrome and its components in elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Pontifícia Universidade Católica do Rio Grande do Sul - Pucrs	Universidade Regional Integrada do Alto Uruguai e das Missões - campus Erechim (Uri-Erechim)	https://ensaiosclinicos.gov.br/rg/RBR-3pdqt5	<NULL>	60 years or older; patients diagnosed with metabolic syndrome; participate of social groups in Erechim, Rio Grande do Sul, Brazil.	Be under nutritional treatment; use or change the dose of lipid-lowering drugs, antihypertensive and hypoglycemic less than three months; be patient with insulin dependent diabetes; alcoholic (alcohol abuse present above 30g ethanol/day); be patient with chronic renal failure, with serum creatinine levels above 1.4 mg/dL; be patient with swallowing disorders; be patient with esophagitis, gastritis and duodenitis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-2bsfm4	Effect of circuit exercises on muscular strength, balance and mood	Not yet recruiting	Intervention	2019-04-12	<NULL>	<NULL>	2596	Impact of a circuit exercise program on the physical-function capacity, on the risk of falls and depressive symptoms int he community-dwelling elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-2bsfm4	<NULL>	Minimum age of 60 years; reside in the community; inactive; with a history of falls and/or risk of falling; not be participating in other research.	Bedridden or wheelchair-bound situation; motion dependent aid device; cognitive deficit; severe visual impairment; amputations or use of lower limb prosthesis; history of recent fracture of the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-83px3n7	Effect of Clareon-toric intraocular lens position on vision after cataract surgery	Recruiting	Intervention	2021-10-14	<NULL>	<NULL>	4987	Effect of Clareon-toric intraocular lens position on post-operative refraction	<NULL>	3, single-arm-study, single-blind	3	<NULL>	<NULL>	<NULL>	2021-06-01	Hospital da clínicas da faculdade de medicina de Ribeirão Preto da universidade de São Paulo	Alcon Laboratórios do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-83px3n7	<NULL>	Volunteers over 18 years old; both genders; cataract presence with formal indication for cataract surgery and corneal astigmatism greater than or equal to 1.0 diopter;.	Any eye disease other than cataracts and astigmatism; surgery or previous inflammation; preoperative refraction with spherical equivalent (refractive error) greater than +5.0 diopters or less than -5.0 diopters; irregular astigmatism; optic nerve or macular abnormalities detected with optical coherence tomography.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-24t799	Effect of cleaning teeth in the levels of c-reactive protein in the blood of patients with severe disease in teeth and bone of the maxilla and mandible	data analysis completed	Intervention	2012-09-28	<NULL>	<NULL>	110	Effect of nonsurgical periodontal therapy on levels of c-reactive protein in serum of subjects with severe periodontitis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-12	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-24t799	<NULL>	Subjects with periodontitis; Periodontitis group: 19 women, nine men; with at least 18 teeth in upper or lower dental arch; be aged a minimum of 20 and maximum of 45 years; no radiographic evidence of bone loss.	History of smoking; pregnancy or lactation; periodontal therapy; antimicrobial therapy for systemic conditions or use of topical oral antibiotics in the last twelve months; diabetes; autoimmune disease; active acute infections; active severe allergies; active gastrointestinal diseases; active renal diseases; active cancer; morbid obesity (Body mass index -BMI-  &gt;40 kg/m2) or underweight (malnourished BMI &lt;18.5 kg/m2); use of medications in the last twelve months that alter the levels of inflammatory mediators.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-4bhr78	Effect of clinical reasoning prompts for nursing students	Not yet recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2017	Effect of clinical reasoning prompts on the diagnostic accuracy of baccalaureate nursing students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Escola Paulista de Enfermagem	Departamento de Enfermagem da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4bhr78	<NULL>	Be a student of the baccalaureate course in Nursing; Have completed and have been approved in the subjects of Fundamentals of Nursing Care, Clinical Nursing and Surgical Nursing of EPE / UNIFESP; or have completed the disciplines of Fundamentals of Nursing Care and Nursing in Adult Health and the Elderly of UFPR.	Medical diagnosis of dyslexia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-8ny87gr	Effect of Clinical Simulation on Teaching-Learning of Cardiac Arrest in Pregnant Women in Hospital Setting	Recruitment completed	Intervention	2026-04-09	<NULL>	<NULL>	9074	Effect of clinical simulation on teaching and learning of cardiorespiratory arrest in pregnant women in an in-hospital setting: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Nursing students; age 18 or older, enrolled in the Nursing Undergraduate Course and enrolled in the fifth to ninth period	Nursing students who do not complete one of the clinical simulation stages and those with special needs that prevent them from carrying out the proposed clinical simulation strategy will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-84b9cd	Effect of clonidine on the target dose of propofol: bispectral index evaluation	Data analysis completed	Intervention	2015-06-25	<NULL>	<NULL>	527	Effect of clonidine on the target dose of propofol: bispectral index evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-15	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-84b9cd	<NULL>	"Patients ASA I or II.
Scheduled for laparoscopic cholecystectomy or jaw fracture treatment in Cariri Regional Hospital. Signing the consent form.
Age between 15 and 65 years. Sample : 51 patients."	"Drug users who can interfere in the outcomes.
Drug Addicts.
Physical state above two.
Refusal to sign the Instrument of Consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-37xt8f6	Effect of co-contraction training on muscle mass, torque and functional capacities in older people	Not yet recruiting	Intervention	2022-07-13	<NULL>	<NULL>	5483	Effect of a coactivation training program, on functional capacity and gait biomechanical parameters, in older people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Marina Mello Villalba	Universidade de São Paulo - Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-37xt8f6	<NULL>	Healthy older; active or non active; aged between 60 to 80 years; available to participate in this research for eight weeks; non participant in any other physical exercise program during this period; all participants must sign an informed consent form.	Walking with an assistive device (cane, crutches, walker); presence of neurological disease; orthopedic impairment in the last 6 months in lower limbs (sprains, ligament ruptures, muscle injuries, fractures and surgeries); backache; vestibular impairment (presence of vertigo or labyrinthitis); non-corrective visual impairment by lenses; low score on the cognitive test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-8ngpq9	Effect of coconut and olive oil in energy expenditure in overweight women	Recruitment completed	Intervention	2016-03-04	<NULL>	<NULL>	738	Acute effect of coconut and olive oil on postmeal thermogenesis and oxidation rate of substrates in overweight women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-20	Universidade Federal de Viçosa - UFV	Universidade Federal de Viçosa - UFV	https://ensaiosclinicos.gov.br/rg/RBR-8ngpq9	<NULL>	Fifteen women will be select to participate in the study; 20 to 40 years old; overweight and with high body fat; basal energy requirements between 1200 to 1500kcal/day.	chronic diseases; weight and physical activity maintenance; use medication that affects some parameter assessed in the survey; smokers; pregnant or lactating; presence of eating disorders; presence of intestinal disorders; alcoholic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-8hcb95v	Effect of Coconut Oil on Vaginal Hydration after Exposure to Cancer Treatment	Data analysis completed	Intervention	2024-07-24	<NULL>	<NULL>	7150	Evaluation of the effect of coconut oil as a vaginal restructuring agent for patients undergoing chemotherapy and radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-26	Centro Universitário CESMAC	Centro Universitário CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-8hcb95v	<NULL>	Women with a confirmed diagnosis of cancer (all types) undergoing chemotherapy or radiotherapy; between 18-50 years old; with an active sexual life; who agree to the Informed Consent Form of this research	Women with secondary amenorrhea or menopause will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-7w8b4rd	Effect of Coenzyme Q10 (CoQ10) supplementation in rehabilitation and palliative care patients in the Home Care Service of a city in the interior of Minas Gerais	Recruitment completed	Intervention	2022-08-09	<NULL>	<NULL>	5537	Coenzyme Q10 (CoQ10) or Ubiquinone supplementation in rehabilitation and palliative care patients in the Home Care Service of a city in the interior of Minas Gerais	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-06	Priscila Evangelista de Melo	Universidade De Franca	https://ensaiosclinicos.gov.br/rg/RBR-7w8b4rd	<NULL>	Volunteers of both genders should be included in the present study; age over 18 with no maximum age limit; who are in the process of illness in rehabilitation; or in oncological palliative care; or in non-cancer palliative care; in any AD1 home care classification; AD2 or AD3; when they are in palliative care, they should be classified by the Palliative Performance Scale from 20% onwards; able to answer fatigue questionnaires; able to answer the quality of life questionnaire proposed in this study; with trunk control that allows sitting; ability to perform the physical strength test using a dynamometer	Volunteers under 18 years of age should be excluded from the present study; in terminal stage of life; insanity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-5ysgfv	Effect of coffee consumption on patients with liver fat	Recruiting	Intervention	2019-08-26	<NULL>	<NULL>	2894	Effect of coffee consumption on clinical variables, intestinal microbiota, oxidative stress and esteatose degree in patients with Non-Alcoholic Fatty Liver disease with or without polymorphism in gene PNPLA3	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-22	Instituto de Nutrição Josué de castro	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-5ysgfv	<NULL>	Patients diagnosed with non-alcoholic fatty liver disease through Fibroscam; both genders; aged between 18 and 65 years.	"Patients with: another cause of hepatic steatosis (alcohol, virus, genetics) or advanced liver disease; chronic kidney disease
thyroid diseases; cushing&apos;s syndrome; cancer; pregnant or lactating women; history of upper gastrointestinal surgery; use of medications for weight loss; report of sensitivity to coffee; consumption of more than 3 cups of coffee per day."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-65dynt	Effect of coffee mouth rinse on cycling performance	Recruiting	Intervention	2020-01-16	<NULL>	<NULL>	3378	Effect of Coffee Mouth Rinse on cycling performance: an randomized cross-over clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-24	Lara Lima Nabuco	Faculdade de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-65dynt	<NULL>	Healthy; normal-weight men; mountain-bike riders; stable body weight over the past three months; regular caffeine users;age between 20 and 40 years old; non-smokers; keep alcohol consumption below seven units / week; experienced cyclists or triathletes (at least 1 year of training) with regular training, maintaining a total of at least 150 km of cycling training per week, with at least 50 km on track.	Individuals who have consumed more than 500 mg of caffeine per day in the last month (~ 5 cups of coffee or tea, cola drinks or caffeine pills); medical condition; food intolerances or allergies;food supplement (except protein, carbohydrate and caffeine); drug treatment that interferes with the test results;those who do not agree with the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-65cxtr	Effect of Coffee on the vascular reactivity of Overweight and Obese individuals	Recruitment completed	Intervention	2019-04-08	<NULL>	<NULL>	3214	Acute effect of Coffee in the Endothelial Function of Overweight and Obesity individuals: A double-blind, randomized, cross-over clinical trial	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-28	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-65cxtr	<NULL>	Individuals older than or equal to 25 years and less than 60 years; both sexes; low risk or intermediate cardiovascular risk characterized by the overall risk score; with overweight and obesity grade I according to the classification of the World Health Organization.	Individuals with high and very high cardiovascular risk, according to the Update of the Brazilian Dyslipidemias Directive and Prevention of Atherosclerosis; not have performed a lipid profile test in the last year; inability to ingest caffeine; infectious diseases active or treated in the last 30 days; neurological disease; type diabetes mellitus; familial dyslipidemia; smokers; hospitalization in the last 2 months; Renal insufficiency; hepatical cirrhosis; chronic obstructive pulmonary disease; coronary artery disease; cardiac insufficiency; atrial fibrillation; severe peripheral arterial insufficiency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-9nrxdf	Effect of coffee with milk on cycling post training recovery	Recruitment completed	Intervention	2020-03-02	<NULL>	<NULL>	4276	Effect of coffee with milk on pathways of glycemic utilization and muscle glycogen recovery after cycling training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9nrxdf	<NULL>	Male adults; cyclists or triathletes. Stable body weight; healthy; regular coffee and milk drinkers. At least recreational trained according to the adapted classification of De Pauw et al. (2013).	Daily caffeine intake greater than 500 mg; athletes with any specific medical condition or recent injury; smokers; illicit drug users; drug treatment. Allergy; intolerance or discomfort with the consumption of milk and dairy products. Athletes who did not agree with the explicit informed consent form (ICF) during the interview could not be selected either.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-10935tq4	Effect of cognitive stimulation in patients with stroke	Recruiting	Intervention	2021-02-08	<NULL>	<NULL>	4521	Effect of cognitive stimulation on the attentional performance of patients diagnosed with stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-09	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10935tq4	<NULL>	The present study will be carried out with individuals of both sexes, aged over 40 years, who suffered a stroke for a maximum of one year.	Illiterate individuals and/or individuals who have significant impairment and who prevent them from carrying out cognitive and mood assessment activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-6fgg7b	Effect of Cognitive Stimulation on falls in the elderly	Not yet recruiting	Intervention	2019-02-26	<NULL>	<NULL>	2490	Effect of Cognitive Stimulation on the prediction of Falls in physically active elderly people	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6fgg7b	<NULL>	Do not have dementia; Do not present severe visual impairment or blindness;Do not present severe hearing loss or deafness; No hemiparesis or hemiplegia due to stroke; Do not present neurodegenerative disease; such as: Parkinson&apos;s disease, Alzheimer&apos;s; Multiple Sclerosis; Amyotrophic Lateral Sclerosis; among others; To be able to wander without using an auxiliary gear; Have the proper medical control of chronic diseases and risk factors; according to medical guidance. Example; Diabetes mellitus and Systolic Arterial Hypertension controlled by drug; ccording to the prescription of a doctor;	1. miss to 25% or more of the total number of meetings held; 2. Suffering hospitalization due to serious reason or hospitalization for more than 24 hours; 3. By choice, leave the research; 4. Suffering Stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-4fvh994	Effect of cold plasma use on pain and chewing during maxillary expansion	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8844	Role of inflammatory mediators, pain perception and masticatory quality in atmospheric cold plasma therapy associated with rapid maxillary expansion: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Volunteers with a clinical diagnosis of unilateral or bilateral posterior crossbite and/or maxillary atresia; Class I or Class II dental malocclusion; first or intertransitional period of mixed dentition; absence of extensive caries lesions and periodontal disease, good general and oral health; absence of previous orthodontic treatment	Volunteers with conditions that compromise oral health at the time of the initial evaluation; with systemic diseases or general health conditions that may interfere with treatment or clinical evaluations; with a history of previous orthodontic treatment; with craniofacial anomalies, genetic syndromes, or cleft lip and palate; continuous or recent use of medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-8zk47ww	Effect of collagen on muscle mass gain and strength in women with lipedema	Not yet recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9095	Effect of supplementation with bioactive collagen peptides on lean mass gain and muscle strength in women with lipedema	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Abralipedema Pro Organização de Ensino Ltda	<NULL>	<NULL>	<NULL>	Women aged greater than or equal to 25 years and less than or equal to 45 years; clinical diagnosis of lipedema stages II to III; regular menstrual cycles or medication-induced amenorrhea; regular physical activity practice greater than or equal to 150 minutes per week; body weight stability with variation less than or equal to 3 percent in the last 3 months; agreement to maintain dietary habits and physical activity level during the study; discontinuation of supplements that may interfere with muscle mass, such as protein supplements, creatine and branched-chain amino acids (BCAA); signing of the Informed Consent Form (ICF).	Pregnant women; breastfeeding women; women planning pregnancy; presence of symptoms or diagnosis of menopause; uncontrolled chronic diseases; relevant musculoskeletal or neuromuscular disorders; fractures within the last 12 months; performance of aesthetic surgeries or liposuction within the last 6 months; recent use of protein supplements or substances that affect body composition; use of medications that significantly interfere with body composition; allergy to supplement components; presence of eating disorders; severe psychiatric disorders; participation in another clinical study within the last 12 months; any condition that prevents adherence to the protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-2xjfkk8	Effect of combination diuretics in patients with acutely decompensated Heart Failure and Acute Kidney Injury: a randomized controlled clinical trial	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7080	Effect of combined diuretic therapy in patients with acutely decompensated Heart Failure and Acute Kidney Injury: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2xjfkk8	<NULL>	Patients of both sexes will be included in the study; older than 18 years; with a previous clinical diagnosis of heart failure; in daily home use of oral loop diuretic (furosemide ≥ 80 mg and ≤240 mg); with clinical signs of volume overload (edema, ascites, pleural effusion or pulmonary congestion); Acute Kidney Injury KDIGO 1 and 2 admitted to the Clinical Emergency Room at the Referred Emergency Room of Hospital das Clinicas de Botucatu	Exclusion criteria will be use of vasoactive drugs, systolic blood pressure less than 90 mmHg; stage 5 chronic kidney disease or KDIGO 3 Acute Kidney Injury on admission; presence of hemodynamically significant arrhythmias; hypokalemia and hyponatremia on admission; inability to comply with planned study procedures or refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-3rvfwt	Effect of combination therapy with Noninvasive Brain Stimulation and Gamotherapy in patients with Parkinson&apos;s Disease	Data analysis completed	Intervention	2019-12-26	<NULL>	<NULL>	3303	Effect analysis of combined therapy with repetitive Transcranial Magnetic Stimulation (rTMS) and gametherapy on motor and cognitive functional capacity of individuals with PD	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal da Paraíba-	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3rvfwt	<NULL>	The study included individuals with clinical diagnosis of PD, of both sexes, with clinical diagnosis of PD, with staging of PD between 1 and 3 on the Hoehn and Modified Yahr scale, who are assisted by SUS, and who agree to participate in the study.	Excluded from this study were: Individuals with PD associated with another chronic neurodegenerative disease; diagnosed with parkinsonian syndrome; individuals with a history of epilepsy; carriers of another disabling condition; and to participate in other physical therapy interventions; have previous experience with Kinect; individuals with functional deficit that makes it impossible to perform the practice proposed by Kinect.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-22ssh2j	Effect of combined Pelvic and Respiratory Muscle Training in women with Urinary Incontinence and COPD	Recruiting	Intervention	2023-11-22	<NULL>	<NULL>	6605	Effect of the association of Training on the Pelvic Floor Muscles and Inspiratory Muscles in women with Stress Urinary Incontinence due to COPD: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-07	Universidade Federal Delta do Parnaíba	Universidade Federal Delta do Parnaíba	https://ensaiosclinicos.gov.br/rg/RBR-22ssh2j	<NULL>	The research will include women from 50 to 70 years old in the city of Parnaíba;  proven clinical diagnosis of COPD (Chronic Obstructive Pulmonary Disease) and urinary incontinence by urodynamics; in addition to presenting good cognitive and verbal conditions; who agreed to participate in the research after reading understanding and signing the Informed Consent Term	Will be excluded from the research volunteers with unstable Chronic Obstructive Pulmonary Disease; with more than four hospital admissions for COPD (Chronic Obstructive Pulmonary Disease)  in the current year; some previous gynecological surgical process; those with low cognition or Mini Mental State Examination score below 19 points for illiterates and below 22 for literate women as recommended by the Ministry of Health	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-2jyc55x	Effect of combined Training with Noninvasive Brain Stimulation on physical and motor performance in Athletes, Adults, and Older People with and without Parkinson Disease	Data analysis completed	Intervention	2026-04-10	<NULL>	<NULL>	9083	Effects of Mixed-Mode Training associated with Transcranial Direct Current Stimulation on physical and motor performance in Athletes, Healthy Adults, and Older Adults with and without Parkinson’s Disease	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-11	Universidade Anhembi Morumbi	<NULL>	<NULL>	<NULL>	Healthy adults and Olympic weightlifting athletes; older adults aged 50 years or older; older adults diagnosed with Parkinson’s disease by a specialist physician in a non-advanced stage and in the ON phase of medication; participants of both sexes	Individuals with orthopedic deformities; other neurological diseases; presence of metal in the head, surgical clips or metallic plates; implanted devices such as pacemakers, deep brain stimulation or cochlear implants; need for assistive devices for locomotion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-7yt65zp	Effect of combining non-invasive brain stimulation of the cerebellum with balance training on improving stability in people with Parkinson&apos;s disease	Recruiting	Intervention	2024-08-12	<NULL>	<NULL>	7206	Effects of multiple sessions of transcranial direct current cerebellar stimulation during dynamic balance training on gains of balance stability in people with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Escola de Educação Física e Esportes da Universidade de São Paulo	Escola de Educação Física e Esportes da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7yt65zp	<NULL>	stages 2 and 3 on the Hoehn and Yahr scale; score ≥ 1 in the posture item of the Movement Disorders Society  Unified Parkinson’s Disease Rating Scale motor subscale; absence of neural implants, absence of neuro-osteomuscular and cognitive dysfunctions, consumption of medications that may affect motor performance; age between 50 to 80 years	Failure to participate in all assessment and training activities; failure to perform the training assignment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-76t2gs	Effect of comparison of stretching and muscle release technique on posterior stiffness of shoulder in professional handball athletes	Recruiting	Intervention	2016-12-06	<NULL>	<NULL>	1088	Effect of stretching the comparison and mobilize myofascial technique in posterior shoulder tightness in professionals handebol athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-22	Universidade Federal de São Paulo	Centro de Traumatologia do Esporte - CETE	https://ensaiosclinicos.gov.br/rg/RBR-76t2gs	<NULL>	Inclusion criteria were established most athletes aged; at least two years of practice; reporting pain or not the shoulder; with ADM limitation	Exclusion criteria were established athletes with anatomical abnormalities; recent history (in the past 6 months) of upper limb injuries; subscapular nerve damage and previous shoulder surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-64rhd5	Effect of complementary therapies on anxiety, facial pain and sleep disorders.	Recruitment completed	Intervention	2019-08-21	<NULL>	<NULL>	2888	Effect of artistic and complementary therapies on the reduction of anxiety, TMD and sleep disturbances.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-64rhd5	<NULL>	Volunteers with one or more symptoms of anxiety, sleep disorder and TMD; both genders; non smokers; age between 20 and 45 years.	Volunteers outside the age group; total edentulous; users of total prostheses; smoking; history of alcohol or drug abuse; users of controlled drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-4hn597	Effect of Concurrent Training on Risk Factors and Fatty Liver in Obese Adolescents	Data analysis completed	Intervention	2013-07-15	<NULL>	<NULL>	212	Study of the Effects of non Pharmacological Training on Components of the Metabolic Syndrome and Fatty Liver Disease in Children and Adolescents with Overweight and Obesityobese Adolescents	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4hn597	<NULL>	Classification of obesity according to the pediatric body mass index (BMI) for age and gender, waist circumference (WC) based on the criteria for age, age between 12 and 15 years on the day of assessment, absence of clinical conditions that made physical activities impossible, a free and informed consent for participation in the program signed by the parents or legal guardians.	Participants aged not compatible with the age proposed by the program, the participant has a disease of metabolic, physical or psychological origin that could prevent the emergence of physical exercise and not be classified as obese by BMI.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-23wvcfk	Effect of consuming foods with health-promoting properties on satiety, blood sugar and lipid levels	Data analysis completed	Intervention	2026-02-05	<NULL>	<NULL>	8833	Effect of functional foods and nutraceuticals on satiety, glycemic control, and lipid profile	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Individuals aged 20 to 50 years; both sexes; diagnosed with type 2 diabetes mellitus; under medical supervision and using a stable dose of oral hypoglycemic agents for at least six months	Pregnant women; individuals with dietary restrictions or participants in dietary restriction programs; individuals with autoimmune diseases, hepatic or renal diseases, or infectious diseases; individuals with food allergies; use of anti-inflammatory drugs, antibiotics, immunosuppressive agents, or nutritional supplements; chronic alcohol users; failure to complete all study assessments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-83jr3x	Effect of consumption of a mix of dried and oiled fruits and dark chocolate (70% cocoa) on the control of cigarette craving in abstinent smokers	Recruitment completed	Intervention	2019-11-01	<NULL>	<NULL>	3163	Effect of the consumption of a mix of dried fruit and oilseeds and bitter chocolate (70% cocoa) on the modulation of craving in smokers on abstinence treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-04	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-83jr3x	<NULL>	Users of more than 20 cigarettes / day, with Systemic Hypertension (SAH) and / or Diabetes Mellitus (DM)	Poly-users of psychoactive substances, people with psychiatric illnesses or cognitive deficits, cancer, Acquired Immunodeficiency Syndrome (AIDS), those who were in nutritional follow-up, and those who did not accept or did not fulfill the aforementioned inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8cy8xb	Effect of consumption of beneficial bacteria associated with diet on body fat, intestinal health and aspects related to the immune system of obese people	Not yet recruiting	Intervention	2020-03-02	<NULL>	<NULL>	3545	Effect of probiotic supplementation associated with dietary intervention on body composition, intestinal microbiota and inflammatory biomarkers in adult individuals obese young people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Camila Guazzelli Marques	Departamento de Psicobiologia da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8cy8xb	<NULL>	Male volunteers; sedentary; age between 20 to 40 years; body mass index (BMI) between 30.0 and 34.99kg / m2, which is obtained by dividing body weight, measured in kilograms, by the square height, measured in meters (kg / m2)	diabetics; vegetarians and vegans; accompanying with a nutritionist; performing any diet or food restriction; gastrointestinal surgery; using antibiotics in the last six months and anti-inflammatory drugs in the last fifteen days and the evaluation weeks; use of weight loss medications and/or antidepressants; use of drugs from the serotonin receptor family; regular consumption of probiotic/fermented products (kefir and kombucha); use of nutritional supplements (probiotics, prebiotics, symbiotics, multivitamins, omega-3, Whey Protein, and creatine); smokers; consumption of alcoholic beverages (&gt; 30.0 grams of alcohol per week); regular physical exercise at least twice a week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-9cb3n9	Effect of consumption of juçara and açaí fruits on free radicals,total cholesterol, LDL, HDL, and triglycerides	Data analysis completed	Intervention	2019-06-07	<NULL>	<NULL>	4618	Effect of acute and long term consumption of juçara fruit (euterpe edulis) and açaí (euterpe oleracea) in antioxidant capacity, oxidative stress and metabolic parameters in healthy subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-9cb3n9	<NULL>	Age between 19 e 59 anos years; Body Mass Index (BMI) between 18.5 e 24.9 kg/m².	Not smoke; not drink alcohol regularly (maximum allowed 1 drink/week, e.g. 1 beer can or 150 mL of wine or 45 mL of distilled beverage); not use medicines or dietary supplements; not pregnant; no clinical condition as cardiovascular, endocrine, gastrointestinal, renal or hepatic diseases; no infections or inflammatory processes visible or, known three months prior to the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-77bg2m	Effect of consumption of native fruits on diabetic individuals	Recruitment completed	Intervention	2020-09-09	<NULL>	<NULL>	4232	Effect of consumption of red araçá pulps (Psidium cattleyanum Sabine) and Butiá (Butia capitata) on glycemic and lipid profiles and on oxidative stress markers in diabetic individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-18	Universidade do Planalto Catarinense	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-77bg2m	<NULL>	This research will include patients over 18 years of age with DM2 who spontaneously want to participate in the study, signing the consent and clarification term (ICF). It is worth mentioning that at any time the selected individuals may abandon the research without prejudice to their treatments.	Patients using insulin; Patients unable to complete the questions as a result of linguistic difficulties, education or unable to attend the previously scheduled assessments; Patients who do not consume fruits of Araça or Butia Patients who have a BMI greater than 35 kg / m2 and have other concomitant health problems. Patients who do not feel comfortable with the research criteria and do not want to participate in the study or do not sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4vm3yy	Effect of convalescent plasma in patients with severe COVI-19	Recruiting	Intervention	2020-05-15	<NULL>	<NULL>	3838	Use of convalescent plasma submitted to pathogen inactivation for the treatment of patients with severe COVID-19	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-19	Instituto Estadual de Hematologia Arthur Siqueira Cavalcanti	Paulo Niemeyer State Brain Institute	https://ensaiosclinicos.gov.br/rg/RBR-4vm3yy	<NULL>	Age &gt; or equal to 18 years; Severe or critical-19 COVID-19; Length of stay &lt; 3 days; Laboratory confirmation of COVID-19 by detection of the viral genome in respiratory secretions, collected by swab; Signature, by the patient or a relative, of the informed consent form	Allergic reactions prior to plasma transfusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-84bk587	Effect of Cookies containing Cashew Nut and Babaçu Flours on the overweight of adolescents	Recruitment completed	Intervention	2026-01-06	<NULL>	<NULL>	8702	Evaluation of the effects of the consumption of Cookies containing Mesocarp Flour of Babaçu on the Glycemic Profile of overweight adolescents: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-08	Centro de Ciências de Imperatriz	<NULL>	<NULL>	<NULL>	Overweight adolescents, with a body mass index (BMI) equivalent to percentiles between 85 and 97 or between +1 and +2 z score (overweight); percentiles between 97 and 99.9 or +2 and +3 z score (obesity) and percentile above 99.9 or +3 z score (severe obesity); age between 17 and 19 years	Adolescents with a history of allergy to babassu or cashew nuts and/or any component that will be used in the formulation of the cookies; and those who have started some nutritional intervention to reduce excess weight	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-5j9k359	Effect of Cooking Oils on Overweight women’s health	Recruitment completed	Intervention	2023-11-10	<NULL>	<NULL>	6568	Effect of Vegetable Oils consumption on obesity-related metabolic markers in women with Excess Body Fat	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-03	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5j9k359	<NULL>	Women; aged between 20 and 41 years; linked at the Universidade Federal de Viçosa; body mass index between 26 and 34.9 kilograms per square meter; body fat percentage above 30; level of food inhibition/disinhibition less than or equal to 14	Smokers; pregnant women; lactating women; women with menstrual irregularities in the last three months; elite athletes; habitual consumption of olive oil or coconut oil; changes in physical activity level and body weight of more than 5 kilos in the last three months; vegetarians; alcoholics; use of supplements or medication; presence of food allergies or intolerances or aversion to the ingredients tested; gastrointestinal diseases; chronic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-7jqpnw	Effect of COVID-19 convalescent plasma produced by HEMOPE: A randomized study, with a comparative group in several centers	Not yet recruiting	Intervention	2020-06-29	<NULL>	<NULL>	3963	Therapeutic effectiveness of COVID-19 convalescent plasma produced by HEMOPE: a multicenter, randomized and controlled clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7jqpnw	<NULL>	adults&gt; 18 years with diagnosis of COVID – 19, who are hospitalized; and considered as having a condition that increases the risk of a worse prognosis: obesity; diabetes mellitus (DM); systemic arterial hypertension (SAH); chronic lung disease, obesity, diseases that alter immunity (AIDS, neoplasms or autoimmune diseases in immunosuppressive therapy, chronic liver disease.	History of anaphylactic reaction related to blood transfusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-4zdtk9n	Effect of cranial magnetic stimulation on pain and mobility of people infected with human T-cell limphotropic virus type 1: randomized clinical trial	Not yet recruiting	Intervention	2021-08-15	<NULL>	<NULL>	4835	Effect of neuromodulation on pain and functional mobility of people infected with HTLV-1 randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Escola Bahiana de Medicina e Saúde Pública	Faculdade de Medicina da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4zdtk9n	<NULL>	To be included in the protocol, the participant must have: age&gt; 20 years; be a carrier of HTLV-1; be a community walker with or without orthosis; with chronic pain (≥ 6 months) in the lower back and / or lower limbs and ability to sign the written consent form	Participants should be excluded if they have: history of epilepsy, cancer, are pregnant women; have a cardiac pacemaker and / or metallic implant in the brain or skull; if they have used illicit drugs and / or alcohol in the last six months; if they use controlled medications; and if they are being accompanied in an exercise program in the 30 days prior to the intervention by rTMS.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-399t4g5	Effect of cranial nerve stimulation on inflammation, normalization of the autonomic nervous system and clinical evolution of patients with Covid -19: a pilot study.	Not yet recruiting	Intervention	2021-06-07	<NULL>	<NULL>	4727	"Effect of Vague Nerve Stimulation on inflammation, modulation autonomic cardiac and clinical evolution of patients with Covid-
19: pilot study"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-07	Universidade Nove de Julho	Centro de Neuromulação Spaulding	https://ensaiosclinicos.gov.br/rg/RBR-399t4g5	<NULL>	Patients over 18 years of age; confirmed diagnosis of COVID-19 from moderate to severe; be able to understand the stimulation treatment that will be performed, receiving supplemental oxygen, non-invasive ventilation, but without being intubated	cochlear implant; have uncontrolled diabetes and hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-2shfhj	Effect of creatine associated with a resistance training on muscle mass, strength and physical fitness in elderly with loss of muscle mass	Recruitment completed	Intervention	2016-09-08	<NULL>	<NULL>	988	Effect of creatine supplementation associated with a resistance training program on muscle mass, strength and physical performance in sarcopenic elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-04	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2shfhj	<NULL>	Between 60 and 80 years of age.	Vegetarian; Have taken any ergogenic aid in the last six months prior to study initiation; ingest any medication that is able to affect muscle growth or the ability to train intensely during the study, such as statins, muscle relaxants, anti-inflammatory; be involved in restricting food programs; be involved in physical training programs; have received contrast or performed radioactive procedure during the last year; is diagnosed with any kidney, liver and heart diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-7r7t52	Effect of creatine supplementation associated with a program of weight training on muscle mass, strength and physical performance in elderly with reduced muscle mass	Data analysis completed	Intervention	2015-03-02	<NULL>	<NULL>	892	Effect of creatine supplementation associated with resistance training on muscle mass, strength and physical performance in Sarcopenic elderly	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-07-04	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7r7t52	<NULL>	Have between 60 and 80 years of age; Be diagnosed with sarcopenia.	Be vegetarian; Take any ergogenic aid in the last 6 months prior to study initiation; Ingest any medication that can affect muscle growth or the ability to train intensely during the study (statins, muscle relaxants, anti-inflammatory); Be involved in restricting food programs; Be involved in physical training programs; Received contrast or performed radioactive procedure last year; Have any kidney disease, liver disease and heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-10gbvjyb	Effect of creatine supplementation on physical performance in physically active women	Data analysis completed	Intervention	2024-08-28	<NULL>	<NULL>	7291	Effects of Creatine Supplementation on Muscle Strength during a Session of Concurrent Training on active women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-10gbvjyb	<NULL>	Being female. Have a normoprotein or hyperprotein diet; Be a practitioner of physical exercise (at least three times/week strength training and at least once/week aerobic exercise); recent strength and aerobic training experience of at least six months; age between 19 and 59 years old	Use of a creatine supplement in the last six months; being using anabolic steroids or steroids; being taking medications that can affect muscle biology (corticosteroids); have kidney disease; have liver disease; be allergic to milk; eggs and/or soy (according to the creatine marketer&apos;s instructions); perform some additional physical exercise that is not part of your daily routine before the protocol; take anti-inflammatories (medication) during the current study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-7m8593	Effect of crochet on pain and mobility in adults with neck pain	Terminated	Intervention	2020-07-27	<NULL>	<NULL>	4759	Immediate effect of crochet on cervical pain and mobility in adult individuals with nonspecific neck pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-10	Vanessa Maria da Silva Alves Gomes	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7m8593	<NULL>	Adult individuals (18 to 45 years old) of both sexes, with cervical pain without cause diagnosed (between the superior nuchal line and the first thoracic spinous process) with more than 3 months in duration. In addition, presenting pain according to the visual analog scale, VAS&gt; 2.	Individuals with symptoms or diagnosis of cervical radiculopathy, cervical myelopathy, cervical ligament instability or inflammatory diseases in the cervical; Herniated disc in the cervical; Temporomandibular disorders; History of spine surgery and / or fracture in the last 12 months; Neoplasms; Rheumatological, infectious, neurological, vascular or systemic diseases; Alteration of skin integrity; Dermatitis; Report of physiotherapy treatment in progress and up to one month before the beginning of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-3s7g4t	Effect of cupping therapy on pain and function in persistent inespecific low back pain: a randomized controlled trial	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	4210	Effect of cupping therapy on pain and function in persistent inespecific low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3s7g4t	<NULL>	Age between 18 and 59 years old, Present persistent nonspecific low back pain	Pregnant women; Women in the postpartum period; Patients who use anticoagulant; Patients who have donated blood in the last 3 months; Anemia; Red flag patients (vertebral fracture; vertebral tumor; vertebral infection; equine tail syndrome; progressive neurological impairment); Systemic diseases (autoimmune; infectious; vascular insufficiency; renal insufficiency; hepatic insufficiency; neoplasia); Fibromyalgia; Lumbar disc herniation; Symptomatic irradiated pain (positive Laségue test); Anterior spine surgery; People with open and poorly healed wounds; Inflamed skin; Alteration of skin integrity; Open fractures; Previous experience of physical therapy treatment in the last 3 months; People who have had previous wind therapy treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-4tq9yq	Effect of Curcumin associated with LED application in the treatment of residual pockets of patients with Chronic Periodontitis and type 2 Diabetes Mellitus	Recruitment completed	Intervention	2018-08-06	<NULL>	<NULL>	2100	Photodynamic effects of Curcumin in the treatment of residual pockets in patients with Chronic Periodontitis and type 2 Diabetes Mellitus: a randomized split-mouth trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-23	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-4tq9yq	<NULL>	Patients with age equal to or greater than 30 years and less or equal than 70 years (MATARAZZO et al., 2008); diagnosis of chronic periodontitis that have undergone periodontal treatment in a period of 3 to 6 months, with at least 4 sites with probing depth (PD) bigger or equal than 5 mm and loss of clinical attachment (CAL) bigger or equal than 3 mm with bleeding on probing (BOP) (APP, 2015); patients diagnosed with type 2 diabetes mellitus (HbA1c equal to or greater than 6.5%) (SACKS et al., 2011); present at least 15 teeth, excluding third molars (ASSEM, 2015); at least 1 site with PD equal to or greater than 5 mm (residual pocket with bleeding on probing) per quadrant.	Smokers or ex-smokers for more than 12 months; patients with anemia; patient with active cancer and history of chemotherapy; history of antibiotic therapy in the previous 6 months; history of anti-inflammatory therapy in the last 6 months; patient with blood disorders; pregnancy; patient in orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-75qb7pp	Effect of curcumin supplementation and physical activity on glycemia, cholesterol and weight loss control in elderly women.	Recruitment completed	Intervention	2021-05-27	<NULL>	<NULL>	4683	Biochemical, Anthropometric and Quality of Life Markers in Elderly Women Undergoing Curcumin Supplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-75qb7pp	<NULL>	The sample will include elderly people, female, aged 60 or over and who are participating in the extension program “Pro life: physical activity and quality of life&quot; and who reached above 17 points in the mini state exam mental.	"Elderly women who are unable to answer questions due to hearing problems or difficulty understanding the questions. Elderly women who are allergic to curcumin or other components of the formula will also be excluded. Patients using
of medications that alter its coagulation characteristics (antiplatelet agents, anticoagulants, low molecular weight heparin and thrombolytic agents), as it may increase the risk of bleeding. Patients at risk of bile duct obstruction or who have gallstones, also those with stomach ulcers and stomach hyperacidity. Medical certificate of release for physical activity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-5ynbgw	Effect of curcumin-loaded nanoparticles in the treatment of periodontitis.	Recruitment completed	Intervention	2020-01-13	<NULL>	<NULL>	3355	Therapeutic potencial of curcumin-loaded nanoparticles in the treatment of periodontitis: Double-blind split-mouth randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-15	Faculdade de Odontologia de Araraquara - Universidade Estadual Paulista	Conselho Nacional de Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-5ynbgw	<NULL>	Healthy; 30 years of age or more; presence of periodontitis, in stage II or III and Grade A, in at least 2 sites in 2 different quadrants, with Probing Pocket depth between 5 and 8 mm and active periodontal disease, verified by the presence of bleeding on probing; minimum 15 teeth present; availability for a period of 6 months	Presence of systemic diseases that contraindicate periodontal treatment, which require antibiotic prophylaxis or use of medications that could interfere with the evolution of periodontal disease and / or treatment outcome; history of gastroesophageal reflux, peptic ulcer, duodenal ulcer and gallstones; gestational or lactating women; smokers or ex-smokers who have stopped smoking for less than 5 years; have been using antimicrobials in the last six months; have been using steroid or non-steroidal anti-inflammatory drugs continuously for more than 7 days in the past 3 months; have received periodontal treatment in the last year; have less than 15 teeth present.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-84vqcn6	Effect of D-Ribose L-Cysteine (RiboCeine) on oxidative stress markers and glutathione levels in healthy individuals	Recruitment completed	Intervention	2024-04-25	<NULL>	<NULL>	6966	Effect of D-Ribose L-Cysteine (Cysteine Ribose) on oxidative stress markers and glutathione levels in healthy individuals aged 40 to 59 years	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-10	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-84vqcn6	<NULL>	Healthy individuals; of both sexes; between the ages of 40 and 59 years	Individuals who use supplements to increase mitochondrial activity; nitric oxide; antioxidants or to reduce inflammation; and who have injuries that may make participation in the study difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-3ntxrm	Effect of daily consumption of brazilian nuts on weight reduction and body composition, energy metabolism, appetite, food intake, metabolic regulators and genetic markers	Terminated	Intervention	2020-02-27	<NULL>	<NULL>	5124	Brazilian nuts study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-3ntxrm	<NULL>	Adult women aged 20 to 55 years; excess weight (equal or greater than 27 kg/m2), high waist circumference (equal or greater than 80 cm), and excess body fat (equal or greater than 32%) associated with at least one other cardiometabolic risk: triglycerides equal or greater than 150 mg/dL, prehypertension (equal or greater than 130 and/or 85 mmHg for systolic and diastolic arterial pressures, respectively) or fasting glycemia equal or greater than 100 mg/dL; or obesity (equal or greater than 30 kg/m2), high waist circumference (equal or greater than 80 cm), and excess body fat (equal or greater than 32%).	Pregnant women, nursing mothers, or women in menopause; athletes; vegans; smokers; with a history of HIV, illness or digestive, liver, kidney, cardiovascular, thyroid, cancer, inflammatory diseases and eating disorders; history of drug and / or alcohol abuse; aversion or allergy to nuts; infectious episode in the last month; use of anti-inflammatory drugs, corticosteroids, antibiotics and others that may affect energy appetite and metabolism; weight instability (5% of usual weight) in the last 3 months; usual consumption of nuts greater than 30 g/day; alcohol consumption greater than 21 units (168g) per week; dental problems that interfere with chewing; consumption of vitamin, mineral and omega 3 supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-8zfn5c	Effect of daily consumption of Castanha-do-Pará (BERTHOLETIA EXCELSA, HBK) on weight loss, metabolism, appetite, food intake, metabolism regulators and genetic markers	Not yet recruiting	Intervention	2020-07-10	<NULL>	<NULL>	4000	Effect of Brazil Nuts (BERTHOLETIA EXCELSA H.B.K) daily consumption on weight reduction and body composition, energy metabolism, appetite, food intake, metabolic regulators and genetic markers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-8zfn5c	<NULL>	Adult women aged 20 to 55 years; excess body fat (equal or greater than 32%) and high waist circumference (equal or greater than 80 cm); overweight (BMI equal or greater than 27 kg/m2) associated with at least one more component of the Metabolic Syndrome, which means triglycerides equal or greater than 150 mg/dL, blood pressure equal or greater than 130 and/or  85 mmHg for systolic and diastolic pressures, respectively, or fasting glucose equal or greater than 100 mg / dL) or; obesity (BMI equal or greater than 30 kg/m2) regardless of the presence of the other components of the Metabolic Syndrome	Women younger than 20 years or older than 55 years; body fat percentage less than 32%; waist circumference less than 80 cm; BMI below 27 kg/m²; BMI between 27 and 30 kg/m², without the presence of any other component of metabolic synddrome, pregnant women, nursing mothers, or menopausal women; athletes; smokers; with a history of HIV, digestive alterations, hepatic or renal diseases, cardiovascular diseases, hypo or hyerthyroidism, cancer, inflammatory diseases and eating disorders; history of drug and/or alcohol abuse; aversion or allergy to nuts; infectious episode in the last month; use of anti-inflammatory drugs, corticosteroids, antibiotics and others that can affect appetite and energy metabolism; weight instability (5% of usual weight) in the last 3 months; daily consumption of nuts (greater than 5g for Brazil nuts and greater than 30 g/day for other nuts); alcohol consumption higher than 21 units (168g) per week; dental problems that interfere with chewing; consumption of vitamin, mineral and omega 3 supplements in tha last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-4twbg5t	Effect of delayed insertion of bulk-fill resin on pain after restorations in posterior teeth	Recruiting	Intervention	2025-08-25	<NULL>	<NULL>	8230	Effect of Decoupling With Time on Postoperative Sensitivity of bulk-fill resin restorations in posterior teeth: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-12	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4twbg5t	<NULL>	Individuals of both sexes. Minimum age of 18 years. Individuals in good general health who have at least one vital posterior tooth, whose vitality can be confirmed by means of a cold stimulation test, in need of restoration due to carious lesions or replacement of an inadequate previous restoration due to aesthetic reasons, fracture or secondary caries. The tooth of interest must necessarily have an opposing tooth in occlusion. The cavities must present occlusal involvement (class I and II) and be at least 4 mm deep, measured at the time of screening using bitewing radiographs and a millimeter ruler and at the time of intervention by measuring the cavity after preparation	Pregnant women; lactating women; those with uncontrolled systemic diseases or who report hypersensitivity to the components of the materials used in the intervention; individuals who have severe periodontitis; non-carious cervical lesions; poor oral hygiene; conditions that may alter the perception of pain, such as neuropathies, chronic pain disorders, severe bruxism and continuous use of medications such as analgesics and anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-6fjfcfg	Effect of Denture use on the ability to swallow in individuals with a history of Head and Neck Cancer	Recruitment completed	Observational	2023-02-16	<NULL>	<NULL>	5908	Effect of bimaxillary complete dentures on swallowing in individuals with a history of head and neck cancer: cross-sectional study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-12	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-6fjfcfg	<NULL>	Edentulous individuals who wear bimaxillary dentures for at least 6 months, undergoing treatment for head and neck cancer in the mouth, oropharynx, hypopharynx or larynx will be included.	Individuals with neurological disorders or cognitive alterations will be excluded; with a history of lung diseases; with oral-sinusal or orofacial communication; patients with poorly fitted bimaxillary total dentures or those who do not use them and; individuals without oral use for food.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-7thqzxp	Effect of desensitizers on the control of dental sensitivity after periodontal treatment	Terminated	Intervention	2025-09-15	<NULL>	<NULL>	8279	Effect of two desensitizing agents in the control of Dentin Hypersensitivity during and after basic periodontal treatment - clinical, randomized and blind study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-11	Colegiado de Odontologia da Universidade Estadual do Oeste do Paraná (UNIOESTE)	Colegiado de Odontologia da Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7thqzxp	<NULL>	Patients of both sexes, between 18 and 70 years old; presence of at least two teeth with dentin hypersensitivity; presence of at least one tooth with an Analog Visual Scale score above 5 cm; presence of exposed dentin in the cervical dental region; with at least two hemiarches affected by hypersensitivity condition; probing depth up to 3 mm; Analog Visual Scale sensitivity value greater than or equal to 4 cm	Dental elements covered by prosthetic work or endodontically treated; patients in constant use or with medical history marked by chronic use of analgesics, anti-inflammatory drugs and psychotropic drugs; patients with orthodontic appliances; patients who have used desensitizers in the last three months; patient who underwent sensitive element restorative treatment for less than a month	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-7t7d4d	Effect of desensitizing gel on sensitivity caused by dental bleaching	Recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3662	Effect of desensitizing gel on sensitivity induced by dental bleaching in the office	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7t7d4d	<NULL>	Patients older than 18 years of age. Male and female. With good general and oral health. Teeth free of caries lesions. Have teeth in color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and that they agree with the informed consent term (TCLE).	Will be excluded volunteers who have already undergone dental bleaching. Who have dental prosthesis; previous dental sensitivity; severe dental dimming by pathologies or medications; fixed orthodontic appliance. Who are pregnant or breastfeeding and who are making continuous use of some medicine that reduces the sensitivity dental.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-3tqv8r3	Effect of devices (Low Power Laser and TENS) on Saliva Increase of Patients with Type II Diabetes Mellitus	Recruitment completed	Intervention	2023-04-13	<NULL>	<NULL>	6005	Effect of Low Power Laser associated or not with the use of TENS in the Salivary Stimulation of patients with Type 2 Diabetes Melittus: randomized controlled clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-15	Universidade de Brasília	Empresa Brasileira de serviços Hospitalares - EBSERH	https://ensaiosclinicos.gov.br/rg/RBR-3tqv8r3	<NULL>	Participate in the Extension UnB Project Periodontal Treatment in Diabetic Patients; having type 2 Diabetes Mellitus;present unstimulated salivary flow value less than or equal to 0.2 ml/min, and stimulated less than or equal to 0.7 ml/min; have controlled periodontal disease; Be between 30 and 65 years old	Presence of severe systemic complications and comorbidities;patients who do not have their glycated hemoglobin levels tested;smokers;transplanted;positive history for epilepsy;patients using electronic devices such as: pacemaker, insulin pump and brain drain;difficulty in motor coordination;presence of systemic conditions that may influence the physiology of the salivary gland, such as: Sjogren&apos;s syndrome, hypothyroidism, history of radiotherapy in the head and neck regions and chemotherapy treatment that preceded 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-29j956	Effect of diacerein in patients with diabetes treated with  antihyperglycemic drugs	Recruitment completed	Intervention	2016-10-24	<NULL>	<NULL>	1057	Effect of diacerein in metabolic control and acute inflammatory markers in patients with type 2 diabetes using andidiabetic agents.	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2014-03-10	Hospital de Clinicas de Porto Alegre	Hospital São VIcente de Paulo	https://ensaiosclinicos.gov.br/rg/RBR-29j956	<NULL>	35 years old and older; HbA1c &gt; 7.5%; type 2 Diabete mellitus withou microalbuminuria and/or nephropaty; Using oral antihiperglicemic drugs(sulfonilureias and or metformin)	Pregnant and lactating women; Chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis; Use of anti-inflammatory drugs for more than 5 days in the last 3 months; Previous diagnosis of pancreatitis; Hypersensitivity to Reina (active metabolite of diacerein) and other antraquinonic derivatives (laxative); Diabetic Nephropathy and \ or kidney failure; Liver disease (transaminases&gt; 2.5 times the upper limit of normality); Severe gastrointestinal disease; Persistent diarrhea (&gt; 3 stools in 24 hours); Signs of intercurrent infection; Participation in another clinical study in past 30 days; Failure to follow the research protocol; using pioglitazone;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-2tfwq3	Effect of diacerein on kidney function, glucose and blod fat metabolism alteration and acute inflamation indicators in type 2 diabetic patients with kidney disease	Recruitment completed	Intervention	2016-11-07	<NULL>	<NULL>	1064	Effect of diacerein on renal function, metabolic control and acute inflamatory parameters in type 2 diabetic patients with nephropaty  - randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2014-03-07	Universidade Federal do Rio Grande do Sul	Hospital São VIcente de Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2tfwq3	<NULL>	Patients from 30 to 80 years old, with type 2 diabetic with microalbuminuria. macroalbuniria and or diminished glomerular filtration rate (GFR - stages 1 and 2); HbA1c from 7.5 to 10%; in regular use of inhibitor Angiotensin Converting Enzyme or Angiotensin Receptor Blocker; Body mass index bellow 40kg / m²; do not make use of pioglitazone; Use of antihyperglycemic medications; Acceptance to participate and to sign informed consent;  Patients seen in the outpatient medical clinic of the Faculdade de Medicina of  Universidade de Passo Fundo	Pregnant and lactating women; presence of chronic inflammatory diseases such as arthritis, colitis; Infectious Disease like  tuberculosis; use of anti-inflammatory drugs for more than five days in the last three months; previous diagnosis of pancreatitis; hypersensitivity to reigns or its correlates (laxative); Smoking; severe liver disease (transaminases major than 2.5 times the upper limit of normal); severe gastrointestinal disease; participation in another trial in the past 30 days; failure to follow the research protocol requirements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-5668v4	Effect of Diet and Omega-3 Supplementation on Markers of Risk for Heart Disease in  Postmenopausal Women	Data analysis completed	Intervention	2013-10-04	<NULL>	<NULL>	255	Impact of Dietary Adequacy and Omega 3 Supplementation on the Metabolic and Inflammatory Markers of Cardiovascular Risk in Postmenopausal Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista  UNESP, Julio de Mesquita Filho	FAPESP - Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5668v4	<NULL>	Women with: (1) date of last menstrual period for at least 12 months, (2) age between 45 and 65 years, (3) at least three criteria for the diagnosis of metabolic syndrome (waist circumference &gt; 88 cm; triglycerides &gt; 150 mg/dL; HDL cholesterol &lt; 50 mg/dL; blood pressure &gt; 130/85 mmHg or under therapy; fasting glucose &gt; 100 mg/dL or under therapy).	The exclusion criteria were: (1) presence of cardiovascular disease manifests current or previous, (2) use drugs that affect lipoprotein metabolism (hormone therapy, statins), (3) alcoholic or drogaditas; (4) story autoimmune diseases, (5) history of malignancy; (6) intolerance or food allergy to fish; (7) insulin-dependent diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-10ftp9pm	Effect of dietary changes for weight loss and fertility parameters in overweight and obese women	Recruiting	Intervention	2024-08-15	<NULL>	<NULL>	7224	Effect of nutritional intervention for weight loss and fertility indicators in Overweight and Obesity women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-10ftp9pm	<NULL>	Women, aged between 20 and 40 years old; Body Mass Index (BMI) values between 25kg/m² and 34.9kg/m² who agree to participate in the work	Body Mass Index values &lt;25kg/m² and &gt;34.9kg/m²; diabetes mellitus (self-reported); elevated Follicle Stimulating Hormone levels (FSH &gt;9.9 nIU/mL), hypothyroidism and hyperthyroidism (TSH ≠ 0.4 to 5 mIU/L)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-4356pb8	Effect of different doses of Weight Training on the Muscle Strength Response and Functional Capacity of untrained elderly women	Recruitment completed	Intervention	2022-10-28	<NULL>	<NULL>	5689	Effect of different doses of Resistance Training on Muscle Strength Responsiveness and Functional Capacity of untrained elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-15	Programa de Pós-Graduação em Ciências do Movimento Humano	Programa de Pós-Graduação em Ciências do Movimento Humano	https://ensaiosclinicos.gov.br/rg/RBR-4356pb8	<NULL>	Be at least 60 years old; feminine gender; present negativity in the Physical Activity Readiness Questionnaire (PAR-Q)	Male gender; volunteers who have completed Resistance Training in the previous year; present an acute or chronic condition that may compromise the execution of tests and protocols; have not completed the assessments; have not completed 8 training sessions within 6 weeks; have suffered any adverse event (injury, illness, disability...) during the training period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-98tx28b	Effect of different foods on blood glucose in Type 2 Diabetes patients	Data analysis completed	Intervention	2021-11-12	<NULL>	<NULL>	5047	Acute glycemic response after adding different foods to breakfast of Type 2 Diabetics	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade de Brasília - Faculdade de Ceilândia	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-98tx28b	<NULL>	Eligibility criteria included the following: male, type 2 diabetic (American Diabetes Association, 2019), age 30–60 years, regular breakfast consumer (≥100 kcal ingested within 2 h of waking on ≥4 d/ week), willingness to eat all test foods, no self-reported allergy to the foods provided in the study, and no self-reported sleep disorders.	Were excluded the participants in use of exogenous insulin, with diabetes health complications, with reported gastrointestinal disorders or irregular intestinal rhythm, and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-4qxt3z	Effect of different forms of electrical stimulation for pain relief in patients with low back pain: a randomized clinical trial	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	880	Effect of different forms of electrical stimulation in patients with low back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-19	Hospital Universitário (HU) da Universidade Federal de Sergipe (UFS)	CNPq- Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-4qxt3z	<NULL>	Volunteers of both genders; aged between 20 and 55; to have nonspecific low back pain for at least 3 months ago; paid work for at least 8 hours per week	patients performing physical therapy or any other method of treatment, pregnant women or mothers who gave birth in the last 3 months; important deformities and / or amputations of lower limbs (LL); low back pain due to infections; tumors; osteoporosis; rheumatoid arthritis; vertebral fracture; radiculopathy or inflammatory processes; skin lesions in the affected region; and infections assets; other nervous or dermal tissue disease affecting the lower back; surgery or invasive examinations of the spine in the last 3 months; inability to understand the instructions or consent for the study; psychiatric diseases; neurological disorders (eg. stroke; Parkinson&apos;s; Alzheimer&apos;s; brain tumor; dementia; multiple sclerosis; substance abuse) or lung such as chronic obstruction oxygen dependent; which could seriously affect the test results; heart disease such as cardiac arrhythmia; angina pectoris; congestive aca card failure; decompensated hypertension; severe comorbidity; contraindication for the use of electroacupuncture, such wounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-9dbpb8n	Effect of different Insoles in patients with Plantar Fasciitis	Recruiting	Intervention	2023-02-13	<NULL>	<NULL>	5904	Effect of different Insoles hardness in patients with Plantar Fasciitis: Randomized control trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9dbpb8n	<NULL>	Participants must be between 30 and 65 years old, both sexes. Participants must present pain for at least twelve weeks and grading at least 3 on the numerical pain scale, in the following situations: in the first steps of the morning and on palpation at the insertion of the plantar fascia located in the medial tubercle of the calcaneus. In addition to at least one of the following criteria: pain after a period of inactivity; pain in the plantar fascia after a recent increase in activities beyond the usual; or Positive Windlass Test.	volunteers who have: Fibromyalgia; musculoskeletal and neuromuscular disorder of a systemic nature; have used custom insoles; have undergone physiotherapy sessions; and have presented musculoskeletal injuries in the lower limbs in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-8p68t8d	Effect of different intensities of aerobic training on sleep disorders and mental health	Recruiting	Intervention	2024-09-24	<NULL>	<NULL>	7370	Effect of different intensities of aerobic training on Obstructive Sleep Apnea and mental health variables	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-30	Escola Superior de Educação Física da Universidade de Pernambuco	Escola Superior de Educação Física da Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8p68t8d	<NULL>	"As inclusion criteria, participants must have a diagnosis of Obstructive Sleep Apnea (snoring, breathing stops and daytime sleepiness) proven by a polysomnography (PSG) test; participants will not be able to meet the minimum recommendations for physical activity in the last three months (at least 150 minutes of light to moderate activity or 75 minutes of vigorous activity) as assessed by a questionnaire; in addition, participants will be included in the study who do not have a medical history of resistant hypertension, cerebrovascular disease, arrhythmias, pacemakers, fibrillation, congestive heart failure, heart disease, emphysema, known ischemic cardiovascular disease, peripheral obstructive arterial disease, renal failure, serious medical problems such as neurological, psychological or cooperation problems that would prevent successful participation in the exercises;
male and female participants will be included; between the ages of 18 and 60"	Participants who do not complete the protocol of at least 80% of the scheduled training sessions in the experimental group and who use sleeping medication will be excluded; participants who have not been diagnosed by a doctor specializing in mental health, but who exhibit anxiety or depression that compromises their participation in the study, will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-9ygmdn	Effect of different kinds of physical training (aerobic, resistance and concurrent) on vascular function and blood pressure in hypertensive individuals	Recruiting	Intervention	2015-06-08	<NULL>	<NULL>	507	Physical Training Effect on Endothelial Function and Blood Pressure in Hypertensive Patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-04	Instituto de Cardiologia - Fundação Universitária de Cardiologia/ ICFUC	Coordenação de Aperfeiçoamento de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9ygmdn	<NULL>	Patients aged between 18 and 75 years; diagnosed with hypertension; not participate in any kind of systematic physical activity; be ranked among insufficiently active, as IPAQ; signing the consent form; not present hyperreactivity during the test the physical tests (SBP&gt; 220 mmHg and / or increase of more than 15 mmHg for DBP); not febrile and / or infectious disease state, as well as diabetes mellitus; not class II obesity or more 35 kg / m2; not present heart failure class III or IV; recent cardiovascular event in the last three months; chronic renal failure; history of malignant disease with a life expectancy &lt;2 years; not be active smoker and not present alcoholism; not have orthopedic impairments or any physical or mental limitation that prevents the performance of physical exercises.	Patients outside the age range of 18 to 75 years; without diagnosis of hypertension; be participating in some kind of systematic physical activity; not sign the Instrument of Consent; hyperreactivity present during the test the physical tests, presenting fever and / or infectious disease as well as diabetes mellitus; class II obesity or having more than 35 kg / m2; present heart failure class III or IV; cardiovascular event in the last 3 months; chronic renal failure; history of malignant disease with a life expectancy &lt;2 years; be active smoker and present alcoholism, have orthopedic impairments or any physical or mental limitation that prevents the performance of physical exercises; will still be excluded from the sample individuals who have not obtained attendance to 85% of the number of training or miss more than two consecutive workouts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-7yspdx	Effect of different low-level laser therapy wavelengths on peripheral blood flow, endothelial function and skeletal muscle fatigue	Data analysis completed	Intervention	2020-08-13	<NULL>	<NULL>	4201	Effect of different low-level laser therapy wavelengths on peripheral blood flow, endothelial function and skeletal muscle fatigue: A randomized crossover trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-08	Centro Universitário Euro-Americano	Centro Universitário Euro-Americano	https://ensaiosclinicos.gov.br/rg/RBR-7yspdx	<NULL>	Healthy young individuals aged 20 - 30 years selected from an existing database in our Extension Program.	History of recent infection (in the past 3 months), use of systemic cortiesteroids (in the last 3 months).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-54c7zt	Effect of different Periodontal Maintenance intervals on the perimplant biological complications.	Recruitment completed	Intervention	2019-09-26	<NULL>	<NULL>	3003	Effect of different Supportive Periodontal Therapy protocols on the incidence of perimplant biological complications.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-54c7zt	<NULL>	to be 40 to 60 years old; to smoke at least 20 cigarrets a day; to have at least 20 teeth; to present more than 20 % of sites with clinical attachment loss  greater than 6 mm and probing pocket depth greater than 5 mm, bleeding on probing. The affected teeth should present more than 30 % of alveolar bone loss; to have lost one or two teeth which need to be replaced by implant supported protheses; to read and sign an informed consent to this study protocol.	need of antibiotic prophylaxis for surgical procedures; history of antibiotics or periodontal therapy in the last six months; use of long term antiinflammatory drugs; history of cronic diseases which could interfere with the course of periodontal diseases, including diabetes, rheumatoid arthritis, immunodeficiencies; pregnancy or nursing; need of alveolar bone regeneration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-5nw4zp	Effect of different protocols in the treatment of tooth sensitivity	Recruiting	Intervention	2020-05-11	<NULL>	<NULL>	4654	Effect of different treatments on dentin hypersensitivity: evaluation of cytotoxicity and randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-05	Universidade Estadual Paulista - FOA	Universidade Estadual Paulista - FOA	https://ensaiosclinicos.gov.br/rg/RBR-5nw4zp	<NULL>	For the in vivo study, patients will be selected who:Age between 20 and 70 years old; regardless of sex; Good health; with no history of allergies to dental products; Presence of at least 1 non-cavitated root exposures or with the beginning of cavitation (without need for restoration), which is sensitive to the jet from a distance of 10 cm.	For in vivo study:Pregnant, lactating or smokers; Presence of active caries lesions; Use of desensitizing agents in the last 6 months; Active and untreated periodontal disease; Use of orthodontic appliance or removable partial denture with clamp on the tooth to be evaluated;Severe bruxism, with more than 50% wear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:31
RBR-7p87yr	Effect of different Toothpastes on tooth enamel	Recruitment completed	Intervention	2018-07-24	<NULL>	<NULL>	2050	Effect of different Toothpaste on dental enamel: a double blind in situ study	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-20	Faculdade de Odontologia de Ribeirão Preto	LaABio - Laboratório de Análise de Biomateriais	https://ensaiosclinicos.gov.br/rg/RBR-7p87yr	<NULL>	Individuals with good general health; aged between 20 and 35 years; without pathologies in the soft and hard oral tissues; not using any type of dental prosthesis or orthodontic appliance; not under medical or dental treatment; who are not participating in no other study	Individuals who use removable prostheses; individuals with altered salivary flow; individuals with decayed teeth or with periodontal disease;  individuals with digestive disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7ptrb5	Effect of different types of exercise on postural balance in elderly women	Recruitment completed	Intervention	2014-07-09	<NULL>	<NULL>	314	Effects of different exercise programs on physical activity variables and physical  functional and psychological fitness of elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7ptrb5	<NULL>	Physically independent; participate voluntarily in the study.	Diagnostics neurological pathologies, skeletal muscle or any mental disorder that interferes interventions and tests; surgery in the locomotor system;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-2nch7x	Effect of Different Types of Implants on the Total Mandible Rehabilitation	Recruiting	Intervention	2018-03-01	<NULL>	<NULL>	1667	Titamax® and Helix® Implants in Protocol Procedures. A Clinical, Controlled, Randomized, Double-Blind and Multicentric Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2nch7x	<NULL>	Age between 18 and 60 years; Necessity of Lower total rehabilitation with osseointegrated implants; To present bone availability associated to the region between the mentual foramen enough for installation of a conventional implant; Presence of good systemic health; All implants should have at least 45N of insertion torque, to allow immediate loading of the implants.	Smokers and former smokers; Diabetics; Patients who use drugs or had pathologies that alter bone metabolism; Patients who use chronically anti-inflammatory and antibiotics drugs; Bruxism; Etilistis; Chemical dependents; Pregnant or wishing to become pregnant next year; History of radiotherapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-9zgxzd	Effect of different types of physical exercise in SUS patients with depression	Recruiting	Intervention	2018-06-19	<NULL>	<NULL>	1915	Effect of different low-cost physical exercise programs on the mood indicator, cognitive function, physical activity level, cardiovascular risk and cost with treatment in patients with SUS depressive disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-20	Universidade de São Paulo - Escola de educação Física e esporte	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9zgxzd	<NULL>	Have a diagnosis of major depressive episode (single or recurrent episode by the Mini International Neuropsychiatric Interview (MINI), evaluated by a psychiatrist-trained evaluator; use of pharmacological treatment for mental health (use of anxiolytic drugs or antidepressants); did not participate in a systematic exercise program in the last 6 months and be able to perform systematic physical exercise (medical authorization); be over 40 years of age; do not have chronic degenerative diseases, dementias (score &lt;23 in the Mini Mental State Examination), joint or muscle injuries that prevent him from carrying out systematized physical exercises.	Not being willing to participate in evaluations; Not having availability of participation of interventions that will occur on weekdays; make use of walking sticks, crutches or other support that hinder the practice of physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-4v6h7b	Effect of different types of physical exercise on cardiometabolic factors in overweight adolescents	Data analysis completed	Intervention	2020-04-09	<NULL>	<NULL>	3732	Effect of aerobic training and high intensity interval training (HIIT) on cardiometabolic factors in overweight adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Prefeitura Municipal de Curitiba	Friends of the Clinical Hospital	https://ensaiosclinicos.gov.br/rg/RBR-4v6h7b	<NULL>	Overweight adolescents; of both sexes; aged between 10 and 17 years; stable weight over a period greater than or equal to 2 months; height greater than 1.45 m, depending on the height of the bicycle seat; not using anorectic drugs or others that could interfere with weight control and controlled hyperinsulinemia and hypothyroidism; be regularly enrolled in school; present the Free and Informed Consent Form signed by the parents or guardians	Present musculoskeletal problems or physical disability that would make it impossible to participate in physical activities; not participating in the second physical evaluation of the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-6343y7	Effect of different types of physical exercise on cardiovascular risk factors in obese adolescents	Data analysis completed	Intervention	2020-03-31	<NULL>	<NULL>	3691	Effect of high intensity interval training (HIIT) and aerobic training on cardiovascular and genetic risk in obese adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-16	Universidade Federal do Paraná	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-6343y7	<NULL>	Individuals of both sexes, aged between 10 and 17 years; Did not present any contraindication to the tests, including absence of cardiac, pulmonary and osteoarticular diseases that compromised muscular strength tests; Do not present contagious diseases of skin (chills, dermatitis, mycoses) that indicate the practice of activities in water; Not to perform other regular physical activity in the last six months, except school physical education (120 min / week); Not participating in any weight loss program; Do not use any medication that interferes with the results of the research.	Obese children and adolescents with infectious-contagious or dermatological diseases that impede participation in the group of aquatic physical exercises; Present musculoskeletal problems or physical disability that would make it impossible to participate in physical activities; Not participate in the second physical evaluation of the project; Participation in at least 75% of classes for exercise groups.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-25vq2fz	Effect of distortion bias in pediatric dentistry studies: a randomized controlled trial	Recruiting	Intervention	2024-07-03	<NULL>	<NULL>	7115	The effects of Spin in the abstracts of articles reporting results of randomized controlled trials in pediatric dentistry: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-06	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-25vq2fz	<NULL>	Any dentists who treat children in their clinical practice regardless of their specialty	Dentists who do not treat children in their clinical routine; dentists that do not want to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-523wzcb	Effect of Docosahexaenoic Acid (DHA) use on the incidence of eye disease of preterm babies	Recruitment completed	Intervention	2023-02-22	<NULL>	<NULL>	6220	Effect of Docosahexaenoic Acid (DHA) supplementation on the incidence of Retinopathy of Prematurity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Secretaria Estadual da Saúde de Santa Catarina	Maternidade Darcy Vargas	https://ensaiosclinicos.gov.br/rg/RBR-523wzcb	<NULL>	Premature babies with mothers older than 18 years of age; up to 33 gestational age;  who were born at Maternidade Darcy Vargas from March 1 2020 to August 31 2022 whose mothers have signed the Free and Informed Consent Form	Premature babies with congenital eye malformation; whose mothers have been supplemented with omega-3 and who have had infectious diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-479v8tv	Effect of dose fractionation of Testosterone on red blood cells in Transgender Men	Recruiting	Intervention	2022-10-27	<NULL>	<NULL>	5684	Effect of dose fractionation of Testosterone Cypionete on hematocrit in Transgender Men with Erythrocytosis secondary to testosterone use	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2022-09-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-479v8tv	<NULL>	Transgender men with and with a diagnosis of testosterone-induced erythrocytosis will be included.	Male transgender (MT) with polycythemia vera or secondary to other pathologies (chronic kidney disease, severe lung disease, chronic myeloid leukemia, lymphoma, liver diseases and Cushing&apos;s syndrome); MT using hormonal contraceptives or copper IUDs; MT with psychiatric conditions such as severe psychotic disorders, severe personality disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-6kvx74	Effect of drug therapy in the treatment of migraine	not yet recruiting	Observational	2012-04-26	<NULL>	<NULL>	138	Additional effect of physical therapy to drug treatment in reducing the intensity and frequency of migraine - a randomized controlled trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2011-11-01	Faculdade de Medicina de Ribeirão preto da Universidade de São Paulo	Departamento de Biomecânica Medicina e Reabilitação do Aparelho Locomotor.	https://ensaiosclinicos.gov.br/rg/RBR-6kvx74	<NULL>	Will be included 50 individuals with migraine, female, aged between 18 and 55. Will be considered only patients with at least two attacks and a maximum of 12 days of pain per month, with disease duration longer than one year, they are only in ambulatory treatment with amitriptyline up to 25 mg for at least 3 months.	Will be excluded women with diagnoses of other concurrent headache diagnosis of migraine, history of cervical trauma and face, with uncontrolled systemic diseases affecting the musculoskeletal system, peripheral nervous system diseases, which have physical therapy in the last one year specific to region or craniocervical posture and have some clinical contraindication to the use of amitriptyline as cardiac arrhythmias, glaucoma and epilepsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-10htn4xy	Effect of Dry Needling on the psychoacoustic characteristics of Somatosensory Tinnitus	Not yet recruiting	Intervention	2024-04-30	<NULL>	<NULL>	6979	Somatic Tinnitus and Trigger Points	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10htn4xy	<NULL>	Over 18 years old; both sexes; constant or intermittent tinnitus, uni or bilateral and chronic; tinnitus must be perceptible at the time of the evaluation, in the in case it&apos;s intermittent; modulation of tinnitus during muscle palpation, at least in one trigger point	Patients with alterations and/or systemic diseases not controlled; patients with diseases of the central nervous system; Patients undergoing treatment using ototoxic medications; Patients with a history of alcohol and/or drug abuse; Patients afraid of needles; patients receiving dry needling treatment previously; patients with impaired language or cognition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-5nryr5	Effect of Duloxetine on inflammation and motor symptoms in patients with Parkinson&apos;s disease	Recruitment completed	Intervention	2018-10-10	<NULL>	<NULL>	2271	Effect of administration of Duloxetine on inflammatory cytokines and motor symptoms in patients with Parkinson&apos;s disease - open-label study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de Santa Maria	Hospital Universitário de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5nryr5	<NULL>	Age older than 40 years, thus excluding early Parkinson&apos;s Disease; with diagnosis of Parkinson&apos;s Disease; using levodopa; for at least two weeks without antidepressants; with a Free and Informed Consent Term read and signed.	If they had dementia, glaucoma or major depression; if they suffered from heart, kidney or liver disease; if they had poorly controlled blood pressure; if they suffered from rheumatological diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-2jnx4s	Effect of ear acupuncture on nursing professionals with stress, anxiety and depression	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3869	Effectiveness of auriculoacupuncture on stress, anxiety and depression in nursing professionals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2jnx4s	<NULL>	Nursing professionals with moderate, severe and extremely severe levels of stress, anxiety and depression, assigned to each sector, with availability to answer questions and scale and participate in the intervention, if selected.	Individuals with infection, inflammation or injury in the ear, use of ear piercing (except for normal earring), allergy to metal or microporous tape; subjects who have some PIC for anxiety, stress and / or depression, being pregnant, being in the puerperium and / or breastfeeding; refuse to receive ear treatment using needles.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-3xbdyym	Effect of Ear Seeds associated with Exercise in people with Chronic Pain	Recruiting	Intervention	2025-06-12	<NULL>	<NULL>	8045	Additional effect of 8 weeks of Auriculotherapy associated with Exercise practice in people with Chronic Musculoskeletal Pain in primary health care: randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Prefeitura Municipal de Diamantina	https://ensaiosclinicos.gov.br/rg/RBR-3xbdyym	<NULL>	Primary Health Care users in the city of Diamantina-MG; both sexes; age between 18 and 65 years; nonspecific low back pain (pain between the lower margins of the ribs and the gluteal folds) (AIRAKSINEN et al., 2006); neck pain; osteoarthritis; pain lasting at least three months; pain intensity with a minimum score of 5 points on the numerical pain scale	Fibromyalgia; neoplasms; radiculopathies; active inflammatory diseases; previous fractures of the spine or lower limbs; previous surgery; other treatment for pain besides exercise in the last 3 months; presence of infection; inflammation or injury in the ear; allergy to microporous tape; use of opioid-type pain relief medications; contraindications for regular physical exercise; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-2snq3hw	Effect of early high-fat tube feeding on intestinal recovery in hospitalized patients	Not yet recruiting	Intervention	2026-02-18	<NULL>	<NULL>	8883	Impact of early lipid-rich postpyloric enteral nutrition on the intestinal microbiome and functional recovery in patients with intestinal failure	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Hospital Universitario de Caldas	<NULL>	<NULL>	<NULL>	Adult patients aged 18 years or older; patients undergoing major abdominal surgery; admission to the intensive care unit in the immediate postoperative period; diagnosis of acute intestinal failure type I; catabolic response to surgical trauma; medical indication for initiation of early enteral nutrition within the first 24 hours after surgery; hemodynamic stability without requirement for high-dose vasopressors; written informed consent signed by the patient or legal representative	Age under 18 years; chronic intestinal failure or short bowel syndrome; uncontrolled sepsis or septic shock at the time of inclusion; hemodynamic instability defined by norepinephrine requirement greater than 0.1 micrograms per kilogram per minute or vasopressin greater than 1 unit per hour; previously diagnosed inflammatory bowel disease; mechanical intestinal obstruction; intestinal ischemia; active gastrointestinal bleeding; prolonged use of systemic antibiotics for more than 14 days prior to inclusion; clinical or technical contraindication to postpyloric tube placement; pregnancy; concurrent participation in another interventional clinical trial	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-6n4q8v	Effect of early intervention program for premature babies who were hospitalized in the Neonatal Intensive Care Unit	Recruitment completed	Intervention	2019-09-27	<NULL>	<NULL>	3005	Effect of a family-centred intervention program on motor and cognitive development of preterm infant of Neonatal Intensive Care Unit: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-11	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-6n4q8v	<NULL>	Infants born preterm (IG below 37 weeks) who are admitted to the neonatal intensive care unit after birth, without congenital orthopedic or central nervous system malformations, and whose parents or guardians sign the Inform Consent forms. The babies should be evaluated after hospital discharge; not exceeding 3 weeks corrected age or 43 weeks postconceptional age	Infants who were born term or post-term (IG above 38 weeks) or preterm infants who were not hospitalized in the Neonatal Intensive Care Unit after birth with congenital orthopedic or central nervous system malformations will be considered as exclusion criteria for the study. whose parents or guardians do not sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-5kkpg6	Effect of eating habits and exposure to light on sleep, emotion, memory and headache in college students during the COVID-19 pandemic	Not yet recruiting	Intervention	2020-06-28	<NULL>	<NULL>	3961	Interaction of food and light synchronization on sleep aspects, cognition and headache in college students during the COVID-19 pandemic	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-29	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5kkpg6	<NULL>	College students regularly enrolled in higher education institutions; both sexes, between 18 and 30 years of age; in social isolation, leaving your home only for essential activities.	Students from colleges, originally with a distance learning method; students from international colleges.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-58n26h	Effect of Education on Learning and the Diabetes Control in Patients Alloy Hypertension UFG	Data analysis completed	Intervention	2011-06-27	<NULL>	<NULL>	190	Effect of Educational Intervention on the Knowledge and Control of Diabetes in Patients of the Hypertension League of UFG	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2010-04-01	Dalma Alves Pereira	Dalma Alves Pereira	https://ensaiosclinicos.gov.br/rg/RBR-58n26h	<NULL>	Being patient with non-insulin dependent diabetes. Not be participating in another research project. Having physical and economic conditions for the displacement. Agree to participate and signing the consent form.	Being insulin dependent. Having obesity grade III. Miss the scheduled service. Does not agree to participate in research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-993xf7	Effect of educational booklet on sleep quality of the elderly	Data analysis completed	Intervention	2020-09-25	<NULL>	<NULL>	4292	Effect of printed Educational Technology on the sleep quality of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-993xf7	<NULL>	Being 60 years old or older, living in the urban area, being assisted by the FHS, having good cognitive status, according to the Mini Mental State Examination, according to schooling criteria and sleep quality index greater than or equal to five points on the Pittsburgh Sleep Quality Index PSQI (which corresponds to poor sleep quality or presence of sleep disorder).	present auditory, visual or speech problems, which prevented the application of the instruments; plan to move to another city, have a surgical procedure scheduled, have a medical diagnosis regarding some type of mental illness and anxiety disorder (to obtain information about this criterion, there was questioning the CHWs and triangulation of data, by checking the medical records of the elderly, in the health unit); identification of risk for depression (obtained from the application of the geriatric depression scale); use antidepressant, sedative and psychotropic medications in general, in addition to chronic use of alcohol, cocaine, crack and amphetamines, for directly interfering in the outcome variable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-10sbrfds	Effect of educational intervention on elderly health beliefs on Sexually Transmitted Infections	Recruitment completed	Intervention	2021-02-09	<NULL>	<NULL>	4528	Effect of educational intervention on elderly health beliefs on Sexually Transmitted Infections: almost experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-03	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-10sbrfds	<NULL>	Age equal to or above sixty years; be registered in the activities of the Municipal Social Assistance Reference Centers; have a telephone contact; be able to communicate verbally; have preserved hearing acuity; have access to a smartphone and know how to use the messaging application.	Do not watch any videos. Those that the researcher can no longer contact.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-6bxq36	Effect of educational programs to promove adverse events reporting	Data analysis completed	Intervention	2018-09-21	<NULL>	<NULL>	2222	Impact of educational intervension for promotion adverse events culture	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-04	Faculdade de Ciências Farmacêuticas Campus Araraquara UNESP	Conselho Nacional Para desenvolvimento Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-6bxq36	<NULL>	Health professionals who worked in the care area of the hospital dependencies during the intervention period; in full; morning, afternoon and evening shifts; with no distinction of professional category	professionals of both genders, on health leave, maternity leave or other reasons for more than 3 months, residents and trainees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-8797spr	Effect of educational video on parents&apos; knowledge about caring for premature newborns at home	Recruiting	Intervention	2024-07-09	<NULL>	<NULL>	7573	Self-efficacy of audiovisual educational technology in parental knowledge about caring for premature newborns at home	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-05-25	Universidade Federal do Piauí	Nova Maternidade Dona Evangelina Rosa	https://ensaiosclinicos.gov.br/rg/RBR-8797spr	<NULL>	Mothers of premature and/or low birth weight newborns hospitalized for more than 24 hours in the neonatal unit. Members of the family and/or social support network will be included, who are primarily responsible for the newborn during hospitalization, whether literate or not	Mothers with hearing impairments and/or psychiatric illnesses (puerperal dysphoria, panic disorder and obsessive-compulsive disorder) that make it impossible to answer the questionnaires; withdrawal from the research after the start of data collection, or non-participation in all stages of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-65tj6zq	Effect of educational video to guide parents and caregivers of children in clean intermittent catheterization: a randomized clinical study	Recruiting	Intervention	2021-12-10	<NULL>	<NULL>	5098	Effectiveness of an educational video to guide parents and caregivers of children in clean intermittent catheterization: a randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-06-14	Departamento de Enfermagem - Universidade Federal do Ceará	Hospital Infantil Albert Sabin	https://ensaiosclinicos.gov.br/rg/RBR-65tj6zq	<NULL>	Volunteers of both genders; literate; being parents or caregivers of children diagnosed with diseases that lead to the use of Intermittent Urethral Catheterization.	Parents or caregivers who have some kind of apparent condition that compromises child care actions; non-attendance at the stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-55vqxv8	Effect of elastic bandage in the acute postoperative phase of the knee ligament	Recruiting	Intervention	2021-06-01	<NULL>	<NULL>	4713	Effect of the application of the kinesio- Taping method in the acute post-operative phase of reconstruction of the anterior cross connection	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	universidade federal de alfenas	universidade federal de alfenas	https://ensaiosclinicos.gov.br/rg/RBR-55vqxv8	<NULL>	Individuals of both sexes; aged between 18 and 40 years; who undergo ACL reconstruction surgery;  are admitted to the hospital where the study was applied	Individuals who are allergic to elastic bandages; who live outside the city of application of the study or who do not have a return visit every seven days with the surgeon; who have postoperative infection, deep vein thrombosis; who have undergone previous surgery of the LCA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-3fs2dm	Effect of Elastic Bandage on Hip Muscles, Trunk and Leg Movement, and Performance on Functional Testing in Healthy Women	Data analysis completed	Intervention	2018-12-12	<NULL>	<NULL>	2382	Effect of Dynamic Tape Functional Bandage on Gluteus Medius Muscle Function, and in Trunk and Lower Limb Kinematics and Functional Performance in Healthy Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3fs2dm	<NULL>	Female subjects; aged between 18 and 30 years old; belonging to the university community; who agreed to participate in the study; were previously enrolled in a Free and Informed Consent Term.	Presence of pain or signs characteristic of musculoskeletal dysfunction in the lower limbs and vertebral column; history of surgery and  or orthopedic dysfunction in the lower limbs in the last year; presence of cardiovascular or respiratory disease that impeded the performance of the study motions; presence of systemic or vestibular disease that affected the balance; presence of peripheral or central metabolic or neurological disease and; history of allergic reaction to the application of elastic bandages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-32sctf	Effect of elastic bandage on swelling after ankle sprain	not yet recruiting	Intervention	2012-01-26	<NULL>	<NULL>	63	Effect of Kinesio Taping on swelling after ankle sprain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-32sctf	<NULL>	People aged 15 to 45 years with acute ankle sprain.	People who have vestibular disorders or previous neurological or musculoskeletal any change that interferes with or contra-indicate the measurement procedures of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-4t949d	Effect of elastic bandage on the jump and balance of athletes	recruitment completed	Intervention	2011-07-17	<NULL>	<NULL>	48	Analysis of the effectiveness of Kinesio Tape on the performance of jumping and dynamic balance in athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4t949d	<NULL>	Men and women, aged between 18 and 45 years, athletes of jump modalities that do not have previous neurological or vestibular disorders, musculoskeletal or any change that interferes with or contra-indicate the measurement procedures of this study	Athletes who are minors, they do not use methods that have jumps and vestibular disorders, neurological or musculoskeletal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-36r3t5	Effect of elastic bandages on pain, swelling and strength in elderly subjects with knee osteoarthritis	Recruiting	Intervention	2014-04-29	<NULL>	<NULL>	287	Effect of kinesio taping on pain, swelling and strength in elderly subjects with knee osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-36r3t5	<NULL>	Volunteers of both gender, age over 60 years, presence of pain in knee (4/10 in visual analogue scale); joint stiffness of the knee at least six months for activities in the standing position; presence of joint pain during passive motion; intermittent swelling; radiographic joint degeneration.	Presence of systemic rheumatic disease; previous surgery of the lower limbs; some other condition that would limit or disable the implementation of proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-65qh7j	Effect of elastic tape on shoulder tendinitis	Recruiting	Intervention	2019-06-11	<NULL>	<NULL>	2752	Kinesio tape in the injuries of the rotating sleeve: clinical test randomizado double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-65qh7j	<NULL>	Rotator cuff lesion grades I and II in the Neer classification; both sexes; age from 18 to 70 years; have signed the informed consent form (TCLE); subacromial pain for at least three months; two of the three positive impact tests (Jobe, Hawkins and Neer).	History of shoulder dislocation and seizure test for positive displacement; intratendine calcifications of the rotator cuff; presence of a proximal humerus anterior fracture; previous surgery on the shoulder; clinical and imaging diagnosis of total rupture in the shoulder rotator cuff tendon; adhesive capsulitis of the shoulder; acronym type III classification of Bigliani on X-ray; use of corticosteroid infiltrations three months prior to the study; presence of rheumatic and neurological diseases; pregnancy; be performing some type of therapeutic intervention for the shoulder in some other service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-4jvybh	Effect of electric and magnetic brain stimulation on physical performance	Data analysis completed	Intervention	2020-09-01	<NULL>	<NULL>	4199	Effect of transcranial direct current stimulation and transcranial magnetic stimulation on physical performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-23	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4jvybh	<NULL>	Aged from 18 to 50 years; take part in physical training with competitive purposes during the last six months; participate in endurance competitions; free from any cardiovascular, musculoskeletal, neurological or psychiatric disease; not taking any medication that could affect the central nervous system (citalopram, amphetamines, L-dopa, sulpiride, pergolide, lorazepam, rivastigmine, flunarizine and carbamazepine); not having contraindications for tDCS (not having metal implanted in the head, pacemaker, medical bumps, seizures, lesions on the scalp or head)	Impossibility to analyze the data due to data loss; injury; voluntary abandonment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-8pjzmsp	Effect of Electrical Brain Stimulation on Pressure, Volume and Brain Activity in Stroke Patients	Data analysis completed	Intervention	2023-03-06	<NULL>	<NULL>	5936	Effect of Transcranial Direct Current Stimulation on Intracranial Pressure and Brain Electrical Activity in the Acute Phase of Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-18	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8pjzmsp	<NULL>	Individuals over 18 years of age; diagnosed with first stroke confirmed by computed tomography or magnetic resonance imaging; ischemic or hemorrhagic; with up to 72 hours of admission; individuals with severe impairment of motor skills, speech or affectivity, the family member/caregiver must express consent as the person legally responsible for the participant by signing the Free and Informed Consent Form.	Individuals with more than 72 hours of admission; clinically unstable; individuals with any metal in the cranial cavity; pacemakers or implanted defibrillators; individuals with lesions in the electrode placement area; without conditions or refusal by the participant or family member to provide informed consent by signing the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-3rx7sr	Effect of electrical stimulation applied on the scalp associated with hip musculature training in women without complaints of urinary incontinence	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1884	Effect of transcranial direct current stimulation (TDCS) combined with pelvic floor muscle training on the contraction force of the pelvic floor muscles in healthy women – Protocol for a randomized, controlled, double-blind, clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-23	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-3rx7sr	<NULL>	Women who had vaginal deliveries age between eighteen and fifty-nine years; No complaint and diagnosis of urinary incontinence; evaluated by Pelvic Floor Impact Questionnaire PFIQ-seven; Sexually active	Women who present with bladder prolapse greater than or equal to two; which prevent the introduction of the vaginal catheter; In treatment with radiotherapy in the pelvic region; In treatment of urinary infection or other conditions in the pelvic region; Pregnant women; Have a pacemaker; That they present contraindications to the use of CTEC history of recurrent seizure; tumors or skin infection at the site of stimulation and metallic materials implanted in the brain; Who presented anesthesia or hyperesthesia at the point of application of the ECTS; Positive cut-off point for the Mini Mental State Examination MMSE lower than eleven points already corrected for schooling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-6wds9b	Effect of electrical stimulation applied on the scalp associated with hip musculature training in women without complaints of urinary incontinence	Recruitment completed	Intervention	2019-01-24	<NULL>	<NULL>	6283	Effect of transcranial direct current stimulation (TDCS) combined with pelvic floor muscle training on the contraction force of the pelvic floor muscles in healthy women - Protocol for a randomized, controlled, double-blind, clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6wds9b	<NULL>	Nulliparous women; sexually active women; women aged between 18 and 45 years, women without complaints of incontinence or urinary tract infection, and women without cognitive impairment assessed by the Mini Mental State Examination	Women who have contraindications for tDCS such as frequent seizure episodes, tumors or skin infection at the site of stimulation and metallic materials implanted in the brain, presence of anesthesia or hyperesthesia at the site of tDCS application; women who have pelvic organ prolapse greater than Stage I of the Pelvic Organ Prolapse Qualification System; pregnant women; women diagnosed with cancer or undergoing palliative care therapy in the pelvic region; women who are being treated for a urinary tract infection or other condition in the pelvic area. Participants must sign the consent form and their data will be kept confidential.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-3s6fk6j	Effect of electrical stimulation applied to the left ear associated with physical training on a bicycle in people with high blood pressure	Not yet recruiting	Intervention	2024-11-12	<NULL>	<NULL>	7506	Effects of Noninvasive Vagus Nerve Stimulation and Aerobic Exercise on Blood Pressure, Cardiac Autonomic Modulation, Inflammation and Functional Capacity in Hypertensive Patients: a controlled, randomized, blinded clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Associação Educacional Nove de Julho	Associação Educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-3s6fk6j	<NULL>	Individuals of both genders diagnosed with mild to moderate hypertension (Stages I and II); over 18 years of age; who use a maximum of 3 classes of drugs; hypertensive individuals with systolic blood pressure (SBP) levels of 140 to 160 mmHg and diastolic blood pressure (DBP) of 90 to 100 mmHg; hypertensive individuals physically fit to perform exercises and with medical clearance for the activity	Individuals with contraindications for the use of vagus nerve stimulation (cochlear implant, metals or skin lesions at the application site); Individuals with a history of ischemic stroke, coronary disease, chronic obstructive or restrictive pulmonary disease, peripheral arterial disease, hyper or hypothyroidism, chronic atrial fibrillation, Diabetes Mellitus, immunodependent, chronic kidney disease on dialysis; Individuals using antihypertensives (beta blockers); pregnant women; Individuals with cardiac pacemakers; Individuals who do not complete all training and who do not perform post-intervention evaluations will be excluded from the final analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-9bjttc	Effect of electrical stimulation applied to the skull on response time and cognition of soccer players	Not yet recruiting	Intervention	2020-04-20	<NULL>	<NULL>	3754	Effect of Transcranial Direct Current Stimulation on Cognition and Reaction Time of soccer players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-05	Universidade Federal do Triangulo Mineiro	Universidade Federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-9bjttc	<NULL>	Individuals of 18-30 years of age; male; right-handed and left-handed; with no associated comorbidities such as orthopedic neurological and visual problems	metal-in-cranium; injuries near the electrode placement area; cardiac pacemaker in situ; intracerebral vascular clips; epilepsy; severe cognitive impairment; previous visual disturbances; depression with scores more than 8 in the Hospital Anxiety and Depression Scale (HAD).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-95x5kmk	Effect of Electrical Stimulation of the brain associated with Physical Exercise for hip Tendonitis and Bursitis	Recruitment completed	Intervention	2023-01-20	<NULL>	<NULL>	6719	Effect of Transcranial Direct Current Electric Stimulation associated with Physical Exercise in patients with Greater Trochanteric Pain Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-30	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-95x5kmk	<NULL>	Voluntaries with greater trochanteric pain syndrome; older than 18 years old; from both genders	Motor or cardiovascular impairment precluding physical exercise; uncontrolled epilepsy; extensive skin lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-5974nc	Effect of electrical stimulation on menstrual cramps	Data analysis completed	Intervention	2019-07-31	<NULL>	<NULL>	2856	Therapeutic effect of high and low frequency transcutaneous nervous electric stimulation in pelvic pain caused by primary dismenorrhea syndrome: a comparative study	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-06-01	SOBEU - Associação Barramansense de Ensino	SOBEU - Associação Barramansense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-5974nc	<NULL>	Age between 18 and 35 years; pelvic pain caused by dysmenorrhea; being between the first and third day of the menstrual cycle, degrees between 1 and 10 on the Visual Analogue Pain Scale (EVA)	Age inferior to 18 and superior to 35 years; use of analgesics and other therapies for pelvic pain; gynecological conditions; undiagnosed abdominal pain; heart pacemaker; cardiac complications; degree 0 on the Visual Analogue Pain Scale (VAS).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-7z5c63	Effect of electrical stimulation on muscle and its result on inflammation, muscle mass and function in cancer patients	Recruiting	Intervention	2020-09-23	<NULL>	<NULL>	4282	Effect of neuromuscular electric stimulation on inflammation, mass and muscular function in patients with cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Tatyanne Letícia	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7z5c63	<NULL>	Cancer patients; both sexes; age over 18 years; admitted to a hospital during the study period.	Serious heart disease; exclusive palliative care; the presence of metallic implants in the region where the electrical stimulus is applied; practice of physical activity in the last six months; amputees; presence of epidermal lesion in the lower limbs; cognitive impairment and expected discharge from hospital less than 14 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-4bk94x	Effect of electrical stimulation on pain and masticatory muscle activity in women with temporomandibular joint dysfunction.	recruitment completed	Intervention	2011-12-06	<NULL>	<NULL>	37	Effect of high voltage electrical stimulation - negative pole - on pain and electromyographic activity of masticatory muscles in women with temporomandibular disorders.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-01-01	Delaine Rodrigues Bigaton	Delaine Rodrigues Bigaton	https://ensaiosclinicos.gov.br/rg/RBR-4bk94x	<NULL>	The study included women with TMD, diagnosed according to RDC / TMD axis I, with pain and / or fatigue in the muscles of mastication during functional activities for a minimum period of six months. The volunteers had body mass index (BMI) of up to 25 kg/m2.	The study excluded women with missing teeth, with dental prosthesis, with systemic diseases such as osteoarthritis, osteoarthritis and diabetes, history of trauma to the face and the temporomandibular joint, joint dislocation, facial paralysis and orthodontic treatment and medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-106mnjhr	Effect of Electrical Stimulation on pain control after facial bone correction surgery in patients with Cleft Lip and Palate	Recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9018	Evaluation of the effect of Transcutaneous Electrical Nerve Stimulation (TENS) on postoperative pain control in Orthognathic Surgery patients with Cleft Lip and Palate	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients presenting with unilateral (left or right side) or bilateral cleft lip and palate. Who are candidates for and eligible for bimaxillary orthognathic surgery. Patients aged 18 years or older. Both sexes	Patients with syndromes. Individuals who have previously undergone orthognathic surgery. Patients with rare facial clefts. Patients with cardiac pacemakers or other implantable electronic devices. History of uncontrolled epilepsy. Pregnant women. Presence of neoplasms in the area of ​​application of Transcutaneous Electrical Nerve Stimulation - TENS. Presence of skin lesions, local infection, areas with altered sensitivity, or any condition that prevents proper electrode placement. Hypersensitivity or intolerance to electrical stimulation. Patients with previous chronic craniofacial pain (such as migraine, trigeminal neuralgia, chronic headaches, post-herpetic neuralgia, fibromyalgia, or other chronic pain syndromes). Patients who have contraindications to the standardized postoperative medication protocol (Sodium Dipyrone and Dexamethasone), such as hypersensitivity, decompensated diabetes mellitus, or other clinical conditions that prevent its administration	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-8xn3qq5	Effect of electrical stimulation on recovery of surgically repaired hand nerves: randomized clinical study	Recruiting	Intervention	2020-12-18	<NULL>	<NULL>	4434	Influence of transcutaneous electrical stimulation on peripheral nerve regeneration after digital nerve neurorraphy: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-10	Hospital Geral do Estado	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-8xn3qq5	<NULL>	Adult patients (over 18 years old), of both sexes, whose surgical procedure has been successful and has been performed within a maximum of two weeks after the injury will be included	Patients with metal implants at the surgery site, who have a history of seizures, who have a cardiac pacemaker, have a local infection or skin lesion that prevents the application of surface electrodes will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:12
RBR-2qpv74b	Effect of electrical stimulation on the head for patients with stress after a traumatic event: controlled phase II clinical trial	Recruitment completed	Intervention	2021-07-01	<NULL>	<NULL>	4771	Effect of Transcranial Stimulation by Continuous Current in patients with Post-Traumatic Stress Disorder	<NULL>	2, single-arm-study, n/a	2	<NULL>	<NULL>	<NULL>	2015-03-01	Federal University of Santa Maria (UFSM)	Federal University of Santa Maria (UFSM)	https://ensaiosclinicos.gov.br/rg/RBR-2qpv74b	<NULL>	Patients over 18 years of age diagnosed with PTSD (Post-traumatic stress disorder) without complete remission of symptoms; maintenance of the pharmacological schedule unchanged in the three weeks preceding the beginning of the proposed treatment and during the proposed treatment.	Patients with psychiatric indication for hospitalization; patients with severe personality disorder; presence of neurological diseases or neoplasms in activity; presence of neurodegenerative diseases; patients with metallic implants and pregnant women and nursing mothers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-2crd42	Effect of electrical stimulation on the scalp associated with exercise in the ability to perform day-to-day movements of elderly individuals	Recruiting	Intervention	2018-07-20	<NULL>	<NULL>	2401	Effect of transcranial direct current stimulation (tDCS) and multicomponent training on the functional capacity of elderly individuals - clinical, controlled, randomized, double blind trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-21	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2crd42	<NULL>	The elderly should be between 60 and 80 years old; accept the terms of the study; both genders; be independent for standing and walking with or without auxiliary devices; to be hemodynamically stable according to the Brazilian Society of Cardiology guidelines lower than the blood pressure of 140mmhg by 90mmhg	Amputation in lower limb or immobilized; musculoskeletal changes that may limit or restrict the performance of training; chronic or progressive neurological changes of central or peripheral origin with motor limitations; limiting or making it impossible to carry out the proposed activities; diagnosis of acute coronary syndrome or patients with severe cardiac events greater than 4 indicated by the functional classification of the new york heart association; pulmonary diseases as chronic obstructive disease; asthma; cystic fibrosis and interstitial lung disease; positive cut-off point for cognitive deficit screening by mini mental status examination with a score lower than 11; visual or auditory deficits or without use of corrective apparatus; heart pacemaker; contraindications to the use of transcranial direct current stimulation; history of seizure or recurrent epilepsy; brain tumors; metallic materials near the stimulus site; infection or skin lesion at the site of stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-9c73cm	Effect of electromyographic biofeedback associated with vocal therapy in dysphonic women	Recruiting	Intervention	2017-10-11	<NULL>	<NULL>	1417	Effect of electromyographic biofeedback associated with vocal therapy in the larynx, voice and muscular electrical activity of dysphonic women: controlled, randomized and blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Faculdade de Odontologia de Bauru/Universidade de São Paulo	Faculdade de Odontologia de Bauru/Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9c73cm	<NULL>	Aged between 18 and 45 years will be included; women; presence of behavioral dysphonia	Report a history of neurological or syndromic diseases will be excluded; Hearing dysfunction; Laryngeal and/or pulmonary surgery; Speech and/or otorhinolaryngological treatment prior to vocal problems; Evidence of behavioral dysphonia of psychogenic origin; Smoking; Participants who do not complete the face-to-face sessions of the proposed interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-9y9p68g	Effect of Electrostimulation on swallowing biomechanics after Radiotherapy	Recruiting	Intervention	2023-05-08	<NULL>	<NULL>	6061	Effect of Electrostimulation on swallowing biomechanics after Radiotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Irmandade Santa Casa de Misericórdia de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9y9p68g	<NULL>	Adult individuals over 18 years of age; diagnosed with head and neck cancer; submitted to radiotherapy in the head and neck region, with or without associated chemotherapy and/or surgery; having finished the radiotherapy and presenting skin integrity and medical clearance to use the technique	Patients with contraindications for electrical stimulation: skin alterations in the region where the electrotherapy will be applied, use of a pacemaker or any other devices or alterations that make electrical stimulation impossible; with an active tumor in the region that will receive electrical current	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-5yy4p9f	Effect of enamel-derived matrix proteins used at different concentrations on bone repair in sinus floor elevation with ceramic material	Not yet recruiting	Intervention	2026-02-16	<NULL>	<NULL>	8877	Effect of enamel-derived matrix proteins at different concentrations on bone repair in sinus floor elevation with biphasic ceramic material - A Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with age be between 18 and 60 years; Patients who require unilateral or bilateral maxillary sinus floor elevation for subsequent placement of osseointegrated implants; Patients must have bone availability associated with the alveolar ridge adjacent to the maxillary sinus less than or equal to 3mm; Patients with good systemic health; Patients that present at least 4 months of post-extraction alveolar healing	Smokers; Uncontrolled diabetics; Patients with chronic or aggressive periodontitis; Patients using medications that alter bone metabolism; Patients with chronic upper respiratory tract infections; Patients who chronically use anti-inflammatory drugs and antibiotics; Patients with bruxism; Alcoholics; Substance abusers; Pregnant women or those wishing to become pregnant in the next year; History of radiotherapy treatment in the head and neck region; Patients with pathologies affecting bone metabolism; Patients who have experienced a large rupture of the sinus membrane during surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-49myxws	Effect of endodontic treatment on serum levels of inflammatory markers of cardiovascular risk in individuals with chronic endodontic infection	Recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9180	Biological mechanisms involved in the association between Asymptomatic apical periodontitis and the risk of Cardiovascular Diseases	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-11	Fundação Universidade Federal do Maranhão	<NULL>	<NULL>	<NULL>	Individuals aged 22 to 25 years; male and female; with a diagnosis of one or more teeth with asymptomatic apical periodontitis; with daily intake of added sugars above the level recommended by the World Health Organization (WHO) (≥10%) in the first phase of the study	Individuals with difficulty changing dietary habits; inability to follow the recommended diet due to religious reasons or disorders of mastication or swallowing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-8z7295b	Effect of execution order of Weight Training and Walking on blood sugar levels in postmenopausal women with type 2 diabetes	Recruiting	Intervention	2023-01-09	<NULL>	<NULL>	5807	Effect of execution order Concurrent Physical Exercise on glycemic acute and subacute response in postmenopausal women with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-31	Programa de Pós-Graduação em Ciências da Saúde	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8z7295b	<NULL>	Postmenopausal women; aged between 45 and 60 years; with the diagnosis of Type 2 Diabetes Mellitus; who presents a medical certificate that allows the patient to practice physical exercise	Making use of hormone therapy; making use of exogenous insulin; being obese (≤30 kg/m2); having complications related to Diabetes; smokers; presenting physical limitations or any pathology that prevents and/or compromises the performance of the physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-4pp8j6	Effect of exercise and dietary control on muscle strength, cardiorespiratory fitness, blood variables and body composition in postmenopausal women	Data analysis completed	Intervention	2016-01-28	<NULL>	<NULL>	695	Effects of physical training and dietary control on muscle strength, cardiorespiratory fitness, blood biochemical variables and body composition in postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4pp8j6	<NULL>	Women; postmenopausal; age between 50 and 79 years at the date of valuation; no physical limitations or any health problems that prevent the implementation of evaluations; possess a medical certificate to perform the cardiorespiratory fitness test, participate in the concurrent training and eating 1.5 ounces per day of taurine;  perform all evaluations; sign the consent form and formal clarification for study participation.	"Hormone replacement therapy; hypertension;
hysterectomy; accumulate three consecutive absences or four non-consecutive absences during the month"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-6pxpx9	Effect of exercise and muscle electrical contraction on the critical patient defense system	Recruitment completed	Intervention	2018-09-21	<NULL>	<NULL>	2221	"Effect of physical exercise and functional electrical stimulation on the immune system of
critical patients"	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2013-11-05	Hospital Agamenon Magalhães	Hospital Agamenon Magalhães	https://ensaiosclinicos.gov.br/rg/RBR-6pxpx9	<NULL>	Critical patients; submitted to mechanical ventilation; no signs of hypertension or hypotension; normal electrocardiogram; show no signs of respiratory distress; clinical-laboratory tests within normal values.	Patient with signs of intracranial hypertension; inability to walk without assistance before acute illness in the ICU; pregnant women; obese; use of cardiac pacemaker; diagnoses of neurological, vascular, orthopedic and oncological pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-8fw6zx6	Effect of Exercise and Respiratory Muscle Training in patients with Heart Failure and Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6375	Effect of Physical Exercise and Inspiratory Muscle Training on Functional Capacity in patients with Heart Failure coexisting with Chronic Obstructive Pulmonary Disease: a controlled clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Instituto de Cardiologia do RS / Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-8fw6zx6	<NULL>	Patients between 50 and 85 years of age; of both sexes; who consent to participate by signing the Free and Informed Consent Form (TCLE); have a clinical diagnosis of heart failure (HF) (ventricular ejection fraction left lower than 50%, secondary to ischemic disease or cardiomyopathies), functional class II and III, according to the New York Heart Association Functional Classification for Heart Failure (NYHA), without associated pulmonary disease; having a clinical diagnosis of chronic obstrutive pulmonary disease (COPD), Global Initiative for Chronic Obstrutive Lung Disease (GOLD) II (50-79% predicted FEV1) and III (30-49% predicted FEV1), based on spirometric evaluation; be clinically stable, in the 30 days prior to inclusion in the study; not having participated or being participating in a rehabilitation program in the three months prior to recruitment	Patients who have an insufficient level of understanding to perform the tests; manifest limitations to perform physical exercise (exacerbation of fatigue, dyspnea on minimal exertion, claudication, unstable angina, uncontrolled arrhythmia); present limiting musculoskeletal diseases; disabling neuropsychiatric diseases; clinical decompensation or recent hospitalization for symptomatic control; coronary event in the last 12 months; aneurysm; patients with a history of spontaneous pneumothorax; history of collapsed lung due to a traumatic injury and that has not completely healed; history of ruptured eardrum that is not completely healed or any other disease in the eardrum; patients with asthma who have frequent attacks; patients who do not adhere to the schedule of activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-103n2zss	Effect of Exercise before and after Arteriovenous Fistula creation in patients with Doença Renal Crônica in the conservative stage: randomised clinical trial	Recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6962	Effect of an Exercise Programm before and after Arteriovenous Fistula (AVF) creation for patients with Chronic Kidney Disease (CKD) in the conservative stage: randomised clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Hospital das Clínicas de Pernambuco	Programa de Pós-Graduação em Fisioterapia da Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-103n2zss	<NULL>	Men and women; aged between 35 and 70 years old; diagnosed with Chronic Kidney Disease (CKD) stage 4 and 5 with a Glomerular Filtration Rate (GFR)  less than or equal to 20 ml/min/1.73 m2, followed up in an outpatient clinic by conservative treatment, who already have an indication to create a radiocephalic Arteriovenous Fistula (AVF) to perform haemodialysis, and patients who have had a distal Arteriovenous Fistula (AVF) fittel	Patients with a previous history of brachiocephalic Arteriovenous Fistula (AVF); those who exercise regularly; a history of vascular surgery in the upper limbs; the presence of vascular access in the upper limbs; occupational activities involving the handling of heavy loads; the presence of traumatic injuries, orthopaedic and rheumatological injuries in the cervical spine, shoulders, elbows, wrists and hands; signs of thrombophlebitis; hypoplasia or agenesis of the upper limbs; presence of cognitive impairment that makes it difficult to understand and finalize the assessment methodology and treatment protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-7js6r9	Effect of exercise on adolescent health risk factors	Not yet recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1608	Combined Physical Exercise and Cardiometabolic Risk Factors in Adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Estadual do Norte do Paraná	Universidade Estadual do Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7js6r9	<NULL>	Be between 15 and 19 years old; not have recognized cardiovascular disease; no diagnosis of diabetes and hypertension; not been participating in a physical activity / exercise program for at least three months; do not present limiting conditions for the practice of physical exercises	Report stage of sexual maturation below IV, present body mass index greater than 40; do not meet pre-participation recommendations on physical tests and weekly sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-8xcxdf	Effect of exercise on aldosterone, cardiovascular variables in patients with renal disease	Not yet recruiting	Intervention	2020-01-14	<NULL>	<NULL>	3359	Effect of home-based exercise on aldosterone, ventricular mass, arterial stiffness in hemodialysis.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8xcxdf	<NULL>	Age greater than or equal to 18 years; both sexes; with CKD in hemodialytic treatment for a period of more than or equal to 3 months; plasma Aldo above 15 ng / dL; do not present contraindications for performing physical activity.	Patients with cognitive deficits, diagnosis of psychiatric disorders; amputees; pregnant women and non-literates; with a previous diagnosis of coronary artery disease; patients considered to be active or very active according to the IPAQ questionnaire, chronic uncontrolled arterial hypertension with BP of 160/100 mm Hg, positive exercise test for cardiac ischemia; patients who suffered a stroke and / or acute myocardial infarction, neoplasia patients; hepatic insufficiency and patients receiving; spironolactone, occurrence of active infection; change in class and / or drug dose; use of antihypertensives; including use of spironolactone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-96j9xn	Effect of exercise on body fat, blood glucose, blood pressure and body damage in type 2 diabetic	Data analysis completed	Intervention	2019-09-11	<NULL>	<NULL>	2934	Effect of a training program on body composition, glycemic profile, blood pressure, inflammatory process and oxidative stress in type 2 diabetics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-30	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-96j9xn	<NULL>	Medical diagnosis of type 2 diabetes at least 12 mouths; 40 to 65 years; 25 to 35 kg/m² BMI; be sedentary or insufficiently active in IPAQ-vc (MATSUDO et al., 2001); regular drug hypoglycemic treatment; do not use insulin and anti-inflammatory drugs.	Changes in drug hypoglycemic treatment; begin chronic use of anti-inflammatory drugs; injuries in muscles; bones and/or tendon; significant changes in nutritional behavior or physical activity; as well as miss 25% of training sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-8pn8fw	Effect of Exercise on older adults that suffering falls in Mato Grosso	Not yet recruiting	Intervention	2019-09-01	<NULL>	<NULL>	6127	Functional Training for fallers older adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-07	Hospital Universitário Julio Muller	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-8pn8fw	<NULL>	Elderly fallers and non fallers; aged 65 years or older; with preservation of intellectual understanding	Cognitive alterations of clinical dementia; visual and auditory problems; labyrinthitis; chronic diseases; fatigue or signs of tiredness; heart diseases; Severe osteoporosis; severe cardiopulmonary disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-9j5pqs	Effect of Exercise on Pain and Disability Related to Spine Pain in the Elderly: A Randomized Clinical Trial	Not yet recruiting	Intervention	2020-11-18	<NULL>	<NULL>	4378	Efficacy of Exercise on pain and disability related to Chronic Low Back Pain in older people: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-9j5pqs	<NULL>	Older peoples men and women aged 60 or over; Complaining of nonspecific low back pain lasting at least 3 months; Disability rated 4/24 or more on the Roland and Morris Disability Questionnaire in the last six months and persistent back pain with 3/10 or more pain on the numerical pain scale in the last six months	Suspected or confirmed severe spinal pathology (fracture, metastatic, inflammatory or infectious diseases of the spine, cauda equina syndrome / generalized neurological disorder); Nerve root compromise; Spine surgery; Major surgeries scheduled during the treatment or follow-up period; Any of the contraindications for exercise listed on page 103 of the American College of Sports Medicine guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-8yzdphh	Effect of Exercise on sexual function in women with Endometriosis	Recruiting	Intervention	2024-04-29	<NULL>	<NULL>	7157	Effect of Pelvic Kinesiotherapy on sexual function in women with Endometriosis: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-02	Faculdade de Ciências da Saúde do Trairi	Faculdade de Ciências da Saúde do Trairi	https://ensaiosclinicos.gov.br/rg/RBR-8yzdphh	<NULL>	Women aged between 18 and 40 will be included in the study; with a clinical diagnosis of endometriosis in the report; and who are sexually active. In addition, participants who do not have an acute or terminal illness will be included; recent fracture in either upper or lower extremity; herniated disc; any chronic illness or orthopedic problems that interfere with your ability to participate in kinesiotherapy; epilepsy; cardiac arrhythmia; cancer; cognitive impairment; difficulty understanding instructions or using instruments; The volunteers included must not be undergoing any other type of treatment for sexual function related to endometriosis, with the exception of drug treatment	Participants who: voluntarily withdraw their consent will be excluded from the study; refuse to complete the assessment and reassessment protocols; do not participate in at least 75% of the scheduled meetings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-6thqfvd	Effect of exercise on signs and symptoms of patients with arm swelling after breast cancer	Recruiting	Intervention	2023-07-26	<NULL>	<NULL>	6278	Effects of resistance and active Kinesiotherapy on signs and symptoms of Lymphedema in patients with Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6thqfvd	<NULL>	Women over 18 years old; who were diagnosed with breast cancer; underwent surgery with axillary dissection; upper limb lymphedema	Mastectomy with bilateral dissection; metastases diagnosed and described in the medical record; angina, diagnosed heart or kidney pathology; previous dysfunction of circulatory or musculoskeletal upper limbs; patients without cognitive conditions to understand the proposed exercises; pregnant women; diagnosed with rheumatological, autoimmune pathologies; with skin lesions that make lymphatic drainage and functional compressive bandaging unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-3qqkss	Effect of exercise on strength and balance of diabetic patients	Recruiting	Intervention	2016-09-30	<NULL>	<NULL>	1024	Comparative evaluation of the effect of aerobic, resistance and combined training on muscle strength and balance in individuals with type 2 diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3qqkss	<NULL>	Individuals with type 2 diabetes mellitus; diagnosis of diabetes for at least 3 years; with diabetic neuropathy; both sexes; aged 50 years; sedentary; able to walk without assistance or supervision from others;	Presence macroangiopathy; history of neurological diseases, muscular rheumatism or outside the etiology of diabetes; presence of uncontrolled hypertension; lack the physical activity program; smokers; dependent on alcohol and illicit drugs; change in the use of corticosteroids, oral hypoglycemic agents or any hypoglycemic diet two months before the start of the exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3r4h5s	Effect of exercise orientations in the posture and plantar pressure distribution in children and adolescents with cystic fibrosis	Recruitment completed	Intervention	2014-07-09	<NULL>	<NULL>	311	Effect of exercise orientations in the posture and plantar pressure distribution in children and adolescents with cystic fibrosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3r4h5s	<NULL>	Individuals with a diagnosis of cystic fibrosis, aged six to twenty years, clinically stable disease and regular follow-up at the cystic fibrosis outpatient clinic.	Children and adolescents with comprehension deficits and/or who present arms/legs problems that would make it impossible to perform the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-825cgv	Effect of Exercise Program in Group and Home-Based Exercise on the Functionality of pre-frail Elderly	Recruitment completed	Intervention	2018-07-11	<NULL>	<NULL>	1996	Effects of the Group and Home Based Exercise Program on the Functionality of pre-frail Elderly	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-825cgv	<NULL>	Women; age from 60 years; frailty detected through validated phenotypic criteria proposed by Fried et al	Elderly women with 3 or more frailty criteria proposed by Fried et al;  with medical  restrictions to physical activity; participating on exercise program in last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-3vt4bs	Effect of exercise training in inflammatory process control in patients with chronic obstructive pulmonary disease	Recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3201	Effect of exercise training in inflammatory process control, mediated by Th17/Treg response in patients with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-19	Hospital das Clínicas da Faculdade de Medicina da USP	Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-3vt4bs	<NULL>	Patients with chronic obstructive pulmonary disease; aged over 50 years; non smokers, of both genders; clinically stable; who have not participated in regular physical training in the last 6 months	Patients with other chronic lung disease; or with rheumatoid arthritis; multiple sclerosis; decompensated diabetes; autoimmune hepatitis; chronic cardiovascular disease; malignant tumor; or with acquired immunodeficiency syndrome - AIDS; use of immunosuppressive drugs; presence of musculoskeletal disorders that make it impossible to perform physical exercise; continuous use of oxygen therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-9m387t	Effect of Exercises and Abdominal Massage compared to Standard Treatment in the Control of Bloating in Women with Irritable Bowel Syndrome	Not yet recruiting	Intervention	2018-04-18	<NULL>	<NULL>	1720	Effect of Kinesiotherapy and Visceral Manipulation compared to Standard Treatment in the Control of Abdominal Distension in Women with Irritable Bowel Syndrome: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9m387t	<NULL>	Women complaining of abdominal distension, aged 18 years or over, diagnosed with Irritable Bowel Syndrome	Acute organic or obstructive gastrointestinal disease, inability to assume the four support position, morbid obesity, psychiatric disorders, alcoholism, psychoactive drug use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-7v6r3t	Effect of exercises to mobility in the orofacial musculature in volunteers with temporomandibular dysfunction: brain function	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2486	Effect of isotonic exercises in the orofacial musculature in volunteers with temporomandibular dysfunction: neurophysiological	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-30	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7v6r3t	<NULL>	Age between 18 and 60 years old; temporomandibular disorder muscular diagnostic reach by research diagnostic criteria; pain between 4 and 10 in numeric scale.	Displacement of the temporomandibular joint; arthralgia; osteoarthrosis; osteoarthritis; advanced neurological and psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-97vs4tt	Effect of Exercises with Partial Blood Flow Restriction on muscular and functional aspects of individuals with difference in muscle strength between lower limbs	Not yet recruiting	Intervention	2023-01-09	<NULL>	<NULL>	5806	Effects of Partial Vascular Occlusion on muscular and functional aspects of individuals with Strength Asymmetry in Lower Limbs	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-97vs4tt	<NULL>	Participants must be between 18 and 59 years old; presence of muscle imbalance, identified by a difference greater than or equal to 10% in muscle strength between the lower limbs and/or presenting values within the upper quartile among all those evaluated, if difference greater than or equal to 5% and medical clearance to perform the test training, provided by the physician associated with the study (Dr. Francisco Wekerlin Morozowski)	Participants will be excluded from the research if they present alterations that make it impossible to complete the questionnaires or understand the guidelines and carry out the tests; systolic blood pressure greater than or equal to 140 mmHg or diastolic blood pressure greater than or equal to 90 mmHg; cannot have more than one risk factor for thromboembolism, which includes: (1) body mass index greater than or equal to 30 kg.m-2; (2) diagnosis of chronic inflammatory disease; (3) history of pelvic, hip, and femur fractures; (4) major surgeries in the last 6 months; (5) diagnosis of varicose veins in the last 6 months; (6) family history of deep vein thrombosis and pulmonary embolism; (7) use of oral contraceptive methods; or (8) tobacco use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-7yryyk7	Effect of exergaming on the quality of life and learning of autism spectrum disorder individuals	Recruiting	Intervention	2022-01-20	<NULL>	<NULL>	5155	Effect of exergaming on the quality of life and learning of autism spectrum disorder individuals	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade do Vale do Sapucaí	Universidade do Vale do Sapucaí	https://ensaiosclinicos.gov.br/rg/RBR-7yryyk7	<NULL>	"Experimental Group 1: volunteers of both genders; aged between 8 and 14 years; who have a diagnosis of autism spectrum disorder; with medical clearance for the practice of the intervention.
Experimental Group 2: volunteers of both genders; aged between 8 and 14 years; do not have a diagnosis of autism spectrum disorder and/or any disease; with medical clearance for the practice of the intervention."	Volunteers under the age of 8 and over 15 will be excluded; cognitive difficulty regarding the assessment and intervention instruments; infectious diseases; incapacitating diseases of the upper and lower limbs; patients with myopathies; diseases with recognized collagen alteration; people with neurological diseases; for personal reasons do not want to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-95crtd	Effect of expanding motor opportunities at the home environment in  infants with risk for developmental delay	Not yet recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1053	Effect of a goal-oriented training with activities and toys at the home environment of infants with environmental and biological risks to delay on neuromotor development	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-30	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-95crtd	<NULL>	Infants with social and environmental risks; infants with biological risk; low socioeconomic status; low parental education; both gender; age at 6 to 8 months old.	Infants with adequate motor development; infants who do not appear in the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-366mbj	Effect of extracted natural agent of grape seed on the longevity of adhesive restorations: clinical trial	Recruitment completed	Intervention	2016-01-04	<NULL>	<NULL>	667	Effect of the proanthocyanidin on the longevity of adhesive restoration: randomized and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-366mbj	<NULL>	"Patients older than 18 years, with good general health, acceptable oral hygiene,
with return periods of availability in the evaluation and who have at least 5 teeth with non carious cervical lesions - NCCLs; The teeth with lesions should have a normal occlusal relationship with the antagonist, not present prior restorative treatment; The wells should not be latched with minimum depth of 0.5 mm and mesiodistal width minimum of 1 mm."	Patients who have dental caries, periodontal problems, dry mouth, bruxism. Pregnant; breastfeeding; patients who are undergoing orthodontic treatment; teeth with sharp occlusal stress.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-10jvnfxg	Effect of familial auditory stimulation on the autonomic function of patients after traumatic brain injury	Recruiting	Intervention	2021-02-09	<NULL>	<NULL>	4529	Neurological and Respiratory Assessment in Individuals with Brain Injury	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Federal do Triângulo Mineiro - UFTM.	Universidade Federal do Triângulo Mineiro - UFTM.	https://ensaiosclinicos.gov.br/rg/RBR-10jvnfxg	<NULL>	The study will include individuals affected by TBI considered severe, scoring from 3 to 8 points on the ECG and RAAS from 0 to -5, whether acute or subacute, from 24 hours to 14 days of admission to the clinical hospital of the Universidade Federal do Triângulo Mineiro, aged over 18 years.	The non-inclusion criteria are hemodynamically unstable individuals, with an increase in MAP above 110 or below 70 mmHg, individuals undergoing brain death protocol, history of hearing impairment, those cases in which it was not possible to define music or musical style preferred by the family and / or whose guardians do not agree with the study and do not sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-3wrnrf	Effect of fibers on intestinal transit and inflammation of patients with Pre-Dialytic Chronic Renal Disease	Not yet recruiting	Intervention	2019-09-28	<NULL>	<NULL>	3010	Effect of prebiotics on intestinal transit and inflammation profile of patients with Pre-Dialytic Chronic Renal Disease.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-30	Faculdade de Medicina de Botucatu - Unesp	Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-3wrnrf	<NULL>	Patients with non-dialytic stage V chronic kidney disease; over 18 years of age; who do not have gastroenterological pathologies; do not have cancer; and do not use continuous laxatives	Patients younger than 18 years of age; with gastroenterological pathologies; pregnant women of any gestational age; cancer; patients on continuous use of laxatives; patients with CKD of any other stage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-4f3rmkt	Effect of filler plastic surgery with Hyaluronic Acid on facial beauty: future research	Recruitment completed	Intervention	2026-04-27	<NULL>	<NULL>	9147	Impact of Hyaluronic Acid Profileplasty on aesthetic perception: a prospective study	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Santo Amaro	<NULL>	<NULL>	<NULL>	Adults between 18 and 55 years old. Both sexes. Good general health. Class I or II (A/B) according to the Angle classification. Agree to and sign the terms of the Informed Consent Form (ICF). Absence of prior facial aesthetic interventions within the last 12 months	Allergy to hyaluronic acid. Allergy to anesthetics such as lidocaine. Marked facial asymmetries. Previous facial surgeries. Coagulation disorders. Autoimmune diseases. Metabolic diseases. Pregnant and lactating women. Active infections, skin lesions, or recent herpes in the treatment area. Presence of permanent materials (PMMA, silicone, and facial prostheses). Class III according to the Angle classification. Recent use of facial fillers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-8pgbfpv	Effect of flavanones of orange juice absorption on blood lipid profile	Recruitment completed	Intervention	2022-08-25	<NULL>	<NULL>	5580	Inter-individual variability in the bioavailability of citrus flavanones and on the lipid profile in humans	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8pgbfpv	<NULL>	Healthy individuals; aged 19 to 40 years; with nutritional diagnosis of eutrophy and / or overweight (BMI = 19.0-24.99 Kg / m2 and 25 to 29.9 Kg / m2). Do not have a history of cardiovascular, gastrointestinal, hepatic or renal dysfunction; not be an alcoholic (daily alcohol consumption); not be diabetic; not have any type of infection; not using vitamin and mineral supplements, in addition to antibiotics, antacids or medication for diarrhea or constipation; not be a smoker; not having an aversion to orange juice; women volunteer cannot be pregnant, breastfeeding or undergoing hormone replacement therapy for menopause.	Present a history of cardiovascular, gastrointestinal, hepatic or renal dysfunction; being an alcoholic (daily alcohol consumption); being diabetic; presenting any type of infection; be using vitamin and mineral supplements, in addition to antibiotics, antacids or medications for diarrhea or constipation; being a smoker; aversion to orange juice; pregnant women, lactating women or menopausal hormone replacement therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-8v96qwb	Effect of Floral Therapy on Anxiety in caregivers of elderly individuals at home	Recruiting	Intervention	2024-05-02	<NULL>	<NULL>	6985	Effectiveness of Floral Therapy in the Anxiety of informal caregivers of dependent elderly individuals at home: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Enfermagem da Universidade Estadual de Campinas - UNICAMP	Faculdade de Enfermagem da Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-8v96qwb	<NULL>	Informal caregivers (who do not receive remuneration for performing this role); of both sexes; aged 18 or older; responsible for the care of elderly individuals (aged 60 or older) participating in the &quot;Better at Home Program&quot; within the Home Care Service of Piracicaba/SP - Brazil; who exhibited moderate or high anxiety according to the State-Trait Anxiety Inventory criteria (score greater than 34)	Female volunteers with suspected pregnancy or already pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-47kfxh	Effect of Floral Therapy on Anxious Overweight Adults	Recruitment completed	Intervention	2018-01-16	<NULL>	<NULL>	3367	Efficacy of Floral Therapy in the Anxiety of Overweight or Obese adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Faculdade de Medicina de Botucatu - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-47kfxh	<NULL>	Healthy individuals; both sexes; literate; aged between 20 and 59 years; overweight or obese (Body mass index greater than 25 kg / m2); and with moderate or high anxiety according to the criteria of the State Anxiety Inventory (Score greater than 34).	Individuals who are taking medications to lose weight or control anxiety or depression; In psychological treatment and / or using other complementary therapies; in addition to women suspected of being pregnant or pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-4msk3yg	Effect of Fludroxycortide and Imiquimod creams in the treatment of lip lesions resulting from chronic sun exposure	Not yet recruiting	Intervention	2023-10-11	<NULL>	<NULL>	6499	Effect of Fludroxicortide and Imiquimod creams on the treatment of Actinic Cheilitis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-05	Fernanda Gonçalves Salum	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4msk3yg	<NULL>	Patients with actinic cheilosis classified as grades III or IV as previously described; Over the age of 30 years; White skinned	The presence of other lesions in lip vermilion in addition to solar cheilitis; Immunosuppression such as transplanted or infected with HIV patients; Any type of treatment for actinic cheilosis in the last six months (except with sunscreen and lip balms; Known allergy to imiquimod or fludroxycortide; Pregnancy or breastfeeding; Histopathological diagnosis of carcinoma in situ or invasive squamous cell carcinoma; History of radiotherapy in the head and neck region; Any condition that may compromise the collaboration in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-5x5k45	Effect of Fluoride Varnish with Phosphate on Dental Caries	Recruitment completed	Intervention	2017-10-30	<NULL>	<NULL>	1453	Effect of Fluoride Varnish containing Sodium Trimetaphosphate on the progression of Dental Caries in vivo: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-18	Faculdade de Odontologia de Araçatuba - UNESP	Faculdade de Odontologia de Araçatuba - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5x5k45	<NULL>	Volunteers must be aged between 3 to 5 years and 11 to 15 years; must agree to participate in the study through free and informed consent signed by parents or guardians; good general health status; did not participate in any other clinical study in the 3 months prior to selection; do not use any other vehicle with fluoride that is not provided by the study investigators.	Voluntary withdrawal; use of mouthwash or toothpaste not provided by the researchers; failure to comply with the clinical protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-6xmd7x	Effect of Fluoxetine on skin coloration in patients with vitiligo: a clinical study	Recruiting	Intervention	2018-07-27	<NULL>	<NULL>	2064	Effect of Fluoxetine in pigmentation of the skin in Vitiligo carriers: clinical study	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2018-07-30	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6xmd7x	<NULL>	Have a diagnosis of segmental or non-segmental vitiligo by dermatologist;be at least 18 years old;have 3 to 50% of the area of the affected body surface	Be carrying out any method of treatment for at least three months, those with any autoimmune disease, patients with more than 50% of the body surface affected, pregnant or lactating women, patients with skin cancer, patients with psychological disorders, patients with photosensitive conditions, vitiligo limited only to the genitals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-7bs22c	Effect of foot insoles in patients with rheumatic joint disease	Recruiting	Intervention	2017-10-31	<NULL>	<NULL>	1458	The effect of foot orthoses on balance in  rheumatoid arthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-31	Faculdade de Ciências MédicasUniversidade Estadual de Campinas	Faculdade de Ciências MédicasUniversidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7bs22c	<NULL>	Patients diagnosed with RA according to the criteria of the American College of Rheumatology of 1987; older than 18 years; stable treatment in the last 3 months; possibility of attending scheduled reassessments; to be literate and able to understand the applied questionnaires and the instructions of the tests of strength and balance; use of shoes that allow the use of insoles	Lower limb involvement due to conditions not associated with rheumatoid arthritis; surgical procedure scheduled for the follow-up period; impairment of cutaneous integrity in the lower limbs; amputation of lower limbs; unbalanced vestibular disease; unbalanced visual disturbance; use of insoles in the last 30 days; use of walking aid for short distances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4hm7mz	Effect of fortification with powder nutrients in prevention and treatment of nutrient deficiency	Recruiting	Intervention	2018-07-23	<NULL>	<NULL>	2039	Effectiveness of fortification with powder micronutrients in prevention and treatment of micronutrient deficiency: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-09	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4hm7mz	<NULL>	Children aged six to 48 months; anemic and non-anemic.	Children in treatment of anemia; malaria; HIV, hemoglobinopathies or hemochromatosis; low weight at birth; preterm birth (less than 37 weeks); twin; allergies reported to any components of the fortification sachet and/or to ferrous sulfate/folic acid.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-9jk2yh	"Effect of FortiFit PRO® supplement associated with resistance exercise and diet
in muscle function of independent elderly
with loss of muscle mass"	Recruiting	Intervention	2020-02-05	<NULL>	<NULL>	3450	"Effect of FortiFit PRO® supplement associated with resistance exercise and diet
in muscle function of independent elderly
with Sarcopenia"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Ibramep - Instituto Brasileiro de Medicina e PEsquisa	Ibramep - Instituto Brasileiro de Medicina e PEsquisa	https://ensaiosclinicos.gov.br/rg/RBR-9jk2yh	<NULL>	"Age over 65 years; Gender: female and male
3) Sarcopenia according to the diagnostic criteria of EWGSOP2: Sarc-F questionnaire: score greater than or equal to 6; Handgrip test (grip strength): men under 27kg, women under 16kg or Stand up / sit test: more than 15 seconds for 5 climbs; skeletal musAgecle mass: men less than 20kg, women less than 15kg or skeletal muscle mass / height2: men less than 7.0 kg / m2; women less than 5.5 kg / m2
- SPPB tests: score greater than 8; Sedentary lifestyle; Independent in relation to activities of daily living (score greater than or equal to 46 on the modified Barthel index)
Rely on support persons (family members or external staff) to assist in following the diet and study recommendations; Having provided written consent to participate in the study, confirmed by signing the Informed Consent Form."	Creatinine clearance less than 35 mL / min; Use of nasogastric tube or gastrostomy; Bedridden patients; Parkinson&apos;s disease; Type 1 diabetes, chronic kidney disease; Severe heart diseases; Other clinical conditions that may, according to medical criteria, make physical exercise and / or food supplementation unfeasible with FortiFit PRO®; Vitamin D level less than 20ng / ml at the end of the run-in period; BMI greater than or equal 30	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-7ny2jgh	Effect of fruit and vegetable based drink on recovery from muscle damage: a double-blind, randomized, placebo-controlled clinical trial	Terminated	Intervention	2021-06-10	<NULL>	<NULL>	4743	Development of fruit and vegetable based smoothies and evaluation of their effect on the recovery of muscle damage	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	João Batista Ferreira Júnior	Instituto Federal do Sudeste de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7ny2jgh	<NULL>	Being involved in moderate physical activities for an average of three days a week; not performing resistance exercise over the past 6 months; no history of musculoskeletal injuries that could impair lower limb muscle performance; not taking any medications or be enrolled in any food restriction program; fit for the study by answering no to all PAR-Q questions	Any history of musculoskeletal injuries that could impair lower limb muscle performance; taking any medications or be enrolled in any food restriction program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-6cwmqc	Effect of Functional Bandaging on Women&apos;s Flexibility	Data analysis completed	Intervention	2018-06-27	<NULL>	<NULL>	1937	Acute effect of the application of Functional Elastic Bandage on the flexibility of active young women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-30	Faculdade Estácio de Sergipe	Faculdade Estácio de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6cwmqc	<NULL>	Physiotherapy students of the Faculdade Estácio de Sergipe; Women; age from 18 to 30 years; they did not practice regular physical exercises; they did not report low back pain at the time of the evaluation	Women who were in the menstrual period, puerperal, presence of scar in the application area and those who presented an allergy to functional elastic bandage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8m9p6ht	Effect of Functional Fitness and Urban Dances on the physical and psychological health of Menopausal Women	Not yet recruiting	Intervention	2024-06-03	<NULL>	<NULL>	7041	Functional Fitness and Urban Dances in the physical and psychological aspects of Menopausal Women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-8m9p6ht	<NULL>	Only menopausal women between 40 and 59 years old who fall into the Menopause Rating Scale; who have serum follicle-stimulating hormone levels greater than or equal to 25 IU/ml; who have not practiced Functional Fitness and Urban Dances in the three months prior to data collection; who refrain from practicing these same types of physical exercise in an environment other than that of the research, during the 12 weeks, however, any other type of physical exercise or physical activity that the participant is already practicing or will carry out throughout the year may be carried out. of this period	Women who do not have menopausal symptoms according to the Menopause Rating Scale cutoff point 1 point; do not abstain from training during the intervention period (12 weeks); those with a history of neurological and musculoskeletal diseases; who have performed aerobic, resistance, or dance training in the three months prior to data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-8v7qhq	Effect of functional foods on Metabolic Syndrome	Data analysis completed	Intervention	2018-05-22	<NULL>	<NULL>	1834	Effect of nutraceuticals on Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Universidade Federal do Estado do Rio de Janeiro	Escola Nacional de Saúde Pública/FioCruz	https://ensaiosclinicos.gov.br/rg/RBR-8v7qhq	<NULL>	Subjects aged 18 or older; carrying Metabolic Syndrome criteria according to the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP ATPIII 2001); who consented formally to join the study	Those who had diagnostic for thyroid abnormalities; hepatic ou renal failure; under treatment for corticoids; hipolipemiant drugs or low calorie diet on the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-85xz9cq	Effect of functional training and resistance training in People with Fibromyalgia	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7949	Effect of functional training versus resistance training in individuals with Fibromyalgia: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal de Sergipe - UFS	Laboratório de Pesquisa em Neurociências	https://ensaiosclinicos.gov.br/rg/RBR-85xz9cq	<NULL>	People with fibromyalgia of both sexes; aged between 18 and 60 years; diagnosis of fibromyalgia based on the recommendations of the American College of Rheumatology of 2016; respond negatively to all questions on the Physical Activity Readiness Questionnaire; physically independent; do not have disorders that prevent them from exercising; have not been engaged in physical exercise for at least three months	Neurological conditions that interfere with evaluations, such as paralysis, significant sensory alterations, and levels of consciousness/comprehension; advanced joint diseases; suspected thrombosis, heart diseases, and immediate post-operative periods; pregnancy; alcohol abuse and illicit substance use; active cancer; initiating another type of physical exercise during the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-89svjw3	Effect of Functional Training on cognition and functionality of elderly women	Recruitment completed	Intervention	2025-04-23	<NULL>	<NULL>	7947	Effect of Functional Training on cognitive health and functional independence in postmenopausal women with Cognitive Impairment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-89svjw3	<NULL>	The sample consisted of elderly women; aged between 60 and 80 years; physically independent and literate; who were not undergoing hormone replacement therapy and had a history of one year since their last menstruation; presenting a Montreal Cognitive Assessment (MoCA) score &lt; 26; and who had subjective memory complaints (SMC); living near the institution and adjacent areas; free from neurological diseases (dementia; Parkinson&apos;s disease; Alzheimer&apos;s disease; multiple sclerosis; depression) or recent surgeries; vision problems (hyperopia; color blindness); hearing; musculoskeletal and cardiorespiratory problems that prevented the practice of high-intensity physical exercises	Attendance below 70%; absence from assessments; engaging in another type of physical activity practice at the same time as the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-6735k46	Effect of functional training on postural control and gait in older adults during associated tasks	Not yet recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8196	Effect of 12 weeks of functional training on postural control and locomotor pattern in dual task stair ascent and descent in older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6735k46	<NULL>	Healthy elderly; men and women; age between 60 and 80 years; preserved cognitive function; independent walking;	Neurological conditions that prevent the performance of experimental tasks; musculoskeletal conditions that prevent the performance of experimental tasks; vestibular conditions that prevent them from performing experimental tasks; health conditions that significantly compromise balance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-55kvhv	Effect of furniture adjustments on posture, pain and discomfort	Recruitment completed	Intervention	2020-08-12	<NULL>	<NULL>	4113	Effectiveness of an ergonomic office  intervention on posture, pain and discomfort - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-55kvhv	<NULL>	Inclusion criteria were that workers were between 18 and 60 years old, who had an office work routine (at least 4h / day on 5 days a week), who agreed to participate in the study by signing the consent form.	Exclusion criteria for the study were: BMI greater than 30 kg / m², not having a fixed job or sharing the job with another worker, using a laptop, using two monitors and having surgery in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6wssng7	Effect of Gentle Touch in children with Cerebral Palsy	Recruiting	Intervention	2024-06-27	<NULL>	<NULL>	7110	Effect of Gentle Touch on cardiac autonomic modulation in children and adolescents with Cerebral Palsy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-11	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-6wssng7	<NULL>	Individuals with cerebral palsy for the CP group and with typical development for the TD group; be between 5 and 18 years old; being able to remain at rest for the application of the assessment and intervention protocol	Have heart disease;  have respiratory diseases; have metabolic diseases; who use medications that alter the autonomic control of heart rate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-2rt2wy	Effect of Ginger on controlling blood sugar and fat levels in people with Type 2 Diabetes Mellitus	Not yet recruiting	Intervention	2017-10-11	<NULL>	<NULL>	1418	Effect of Ginger (Zingiber Officinale) on glycemic and lipemic control of people with Type 2 Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-23	Universidade Estadual do Piauí	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2rt2wy	<NULL>	Volunteers with type 2 diabetes for at least 2 years;both sexes;age between 20 and 80 years;be enrolled and monitored in the E-SUS AB system;treatment with oral antidiabetics;have glycated hemoglobin between 7 and 10%.	Smoking volunteers;history of alcohol abuse; gestation and lactation;consumption of ginger in the usual diet;cognitive alterations;diagnosis of diabetes pathologies or complications such as heart, renal, gastrointestinal and hepatic heart diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-33jpyy	Effect of Ginger on reducing nausea and vomiting and on quality of life in patients undergoing Chemotherapy	Recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1496	Effect of Ginger in the occurrence of nauses and vomiting and on the quality of life in patients submitted to Chemoteraphy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Hospital das Clínicas Universidade Federal de Goiás - GO	Hospital das Clínicas Universidade Federal de Goiás - GO	https://ensaiosclinicos.gov.br/rg/RBR-33jpyy	<NULL>	"Aged between 20 and 80 years;
Individuals apt of swallowing capsules; Individuals with a confirmed diagnosis of cancer, being treated with chemotherapy ; Individuals who have undergone at least one CT cycle with the same chemotherapeutic agent and who have experienced nausea or vomiting  as a result of such treatment; Individuals with platelet counts&gt; 100 000/microliters before the initialcycle."	Individuals with ginger allergy or who have made use of it in the last week; Patients on heparin or other anticoagulant medication or who have some bleeding disorder; Patients submitted to chemoterapy associated radiotherapy during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-6th946x	Effect of global postural reeducation - GPR on pain and muscle function in subjects with temporomandibular dysfunction	Recruitment completed	Intervention	2021-04-02	<NULL>	<NULL>	4598	Effect of Global Postural Reeducation - GPR on Pain and Muscle Function in Subjects with Temporomandibular Dysfunction: A Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6th946x	<NULL>	Patients of both sexes; aged between 18 and 45 years; presenting with myofascial TMD	Will be excluded from the study patients with comorbidities and those taking analgesic, anti-inflammatory, myorelaxative or antidepressant medications, as well as patients undergoing physiotherapeutic, orthodontic or phonoaudiological treatment. For females, patients taking oral contraceptives at the time of the study will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-4gzj9m	Effect of Gluten Consumption on pain sensitivity of women with Temporomandibular Dysfunction	Recruiting	Intervention	2018-06-02	<NULL>	<NULL>	1865	Influence of Gluten Intake on mechanical somatosensory mechanisms of women with Myofascial Pain of the Masticatory Musculature	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-23	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4gzj9m	<NULL>	Women. 20 to 45 years. Myofascial Pain in Masticatory Musculature for at least 3 months. Pain rating of at least 5.	Toothache. Fibromyalgia. Primary Headache. Diabetes uncontrolled. Uncontrolled hypertension. Lupus. Leprosy. Multiple sclerosis. Hypothyroidism. Carpal tunnel syndrome. Intracranial hypertension. Pregnancy. Previously diagnosed disabling psychological and neurological changes. Chikungunya fever. Dieting restrictive. Present signs and symptoms of intolerance, sensitivity or allergy to gluten. They should not have been treated for TMD in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-9tvfk2	"Effect of GPR 
on rehabilitation  and sleep after stroke"	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2688	"Effect of Global Posture Reeducation 
on rehabilitation  and sleep after stroke"	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-03-20	Fundação de Amparo à Pesquisa do estado de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9tvfk2	<NULL>	Patients of both sexes, with age greater than or equal to 18 years of age; Patients with Apnea and Hypopnea Index ? 15;  Patients with a history suggestive of a first acute stroke will be invited or may apply to participate in the study; Subacute stage of stroke (between 30 days and 3 months after disease onset); Magnetic Nuclear Resonance or Computed Tomography of the brain performed after hospital admission demonstrating ischemic or hemorrhagic stroke; Patients with NIHSS scores for stroke between 5 and 20 (moderate to moderate / severe stroke-motor impairment) at the time of entry study evaluation; Availability of attendance at physical therapy and assessment sessions; Accept in participating in the study and signing the Informed Consent Term (TCLE).	Patients with other associated neurological or sleep disorders that interfere with rehabilitation;Patients with renal insufficiency; Previous presence of stroke, subarachnoid hemorrhage or due to secondary cause, malformation, vasculitis, brain tumor or head trauma; Use of potent sedative drugs or continuous sedation; Patients with associated restrictive pulmonary or peripheral vascular diseases; Patients with congestive heart failure or class III or IV heart failure of the New York Heart Association Functional Classification; Non-cooperative patients due to lowering of level of consciousness, impairment of language, vision or important cognitive (verified by Montreal Cognitive Assessment (MoCA, Simões et al, 2008); Previous sleep breathing disorders under treatment; Patients who miss physical therapy sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-786v9gq	Effect of grape juice intake on inflammatory response in overweight women.	Recruitment completed	Intervention	2021-02-05	<NULL>	<NULL>	4509	Effect of grape juice ingestion on microRNA expression in plasma and mononuclear cells in overweight women.	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2017-08-18	Food Research Center São Paulo State Research Foundation (FAPESP)	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-786v9gq	<NULL>	"Women between eighteen and forty years old; BMI between twenty-five and 
twenty-nine and nine kg/m² and be willing to adhere to the study protocol and sign the informed consent form (ICF)."	Men; age under eighteen or over forty years old; BMI less than twenty-five kg/m² or greater than twenty-nine and nine kg/m²; be an athlete; diagnosis of diabetes mellitus; use medication to control inflammation, plasma lipid profile or systemic blood pressure; make use of vitamin supplements, probiotics, prebiotics, symbiotics, antibiotics or any other medication that may interfere with the intestinal microbiota; habit of frequently consuming grape juice; alcohol consumption in seven days prior to the study; smoker; presence of any chronic gastrointestinal disease (for example, inflammatory bowel disease, celiac disease, cancer); pregnant and or participating in another study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:19
RBR-9832wsx	Effect of green and black tea kombucha consumption on gut bacterias and changes in metabolic markers in individuals with normal and excess body weight	Recruiting	Intervention	2021-05-14	<NULL>	<NULL>	7296	Effect of consumption of kombuchas from green and black teas on gut microbiota and metabolic alterations of eutrophic and excess body weight individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-25	Departamento de Tecnologia de Alimentos da Universidade Federal de Viçosa	Departamento de Tecnologia de Alimentos da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-9832wsx	<NULL>	Individuals with an age between 18 and 45 years old; individuals in the eutrophic group must have a body mass index between 18.5 and 24.9 kg per m2; body fat percentage of up to 25 for men and up to 30 for women; waist circumference less than 88 cm for women and 102 cm for men; individuals in the excess weight group must have a body mass index of at least 27 kg per m2; body fat greater than 25 percent for men and 30 for women; waist circumference greater than 88 cm for women and 102 cm for men	Individuals with other chronic diseases such as diabetes, cancer, cardiovascular disease, renal or hepatic dysfunction, anemia and inflammatory diseases not related to obesity; individuals who have a habit of consuming kombucha; make regular use of antiinflammatory drugs, corticosteroids or other drugs that affect lipid or glucose metabolism; make use of antioxidant and vitamin supplements; used antibiotics less than 3 months before the beginning of the study; have had infectious or allergic episodes in the last month; individuals under weight-loss diets or that do not have a stable weight in the last 3 months; have aversion to kombucha; have alcohol intake greater than 105 g of ethanol per week for women and more than 210 g of ethanol per week for men; smokers; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-379g2cz	Effect of Green Banana Biomass on Overweight men and women’s health	Recruiting	Intervention	2024-03-30	<NULL>	<NULL>	6902	Effect of Green Banana Biomass consumption associated with Energy Restricted Diet on gut and related variables in individuals with Excess Weight and Body Fat	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-16	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-379g2cz	<NULL>	Men and women; between 20 and 40 years old; body mass index between 25 and 34.9 kilograms per meter squared; body fat percentage above 30; food inhibition/disinhibition level less than or equal to 14; weight loss of less than 3 kilograms in the last 12 weeks; level of physical activity stable between irregularly active and active; who consume breakfast regularly	Smokers; pregnant/breastfeeding women; women who have menstrual irregularities in the last three months; elite athletes; consumption of probiotics, prebiotics or synbiotics more than 2 times/week in the month before the start of the study; changes in the level of physical activity and body weight greater than 3 kilos in the last three months; vegetarians; regular consumption of alcohol; use of supplements or medications; presence of allergy or food intolerance or aversion to the tested ingredients; gastrointestinal diseases; chronic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-9fvwk4m	Effect of green propolis on periodontal treatment of type 2 diabetics	Recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6298	Effect of green propolis supplementation on non-surgical periodontal treatment of individuals with type 2 diabetes: randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-03-09	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9fvwk4m	<NULL>	Participants with type 2 diabetes mellitus and periodontitis stages II and III, with a minimum age of 30 years and at least fourteen teeth present in the oral cavity, and who agree to participate in the research through an informed consent form will be included.	The following individuals will be excluded from the study: with a history of allergy to pollen or any product of apiarian origin; carriers of diseases with changes in the immune system; smokers; pregnant and lactating women; who have undergone periodontal treatment in the last 6 months; who have undergone antimicrobial and anti-inflammatory therapy in the last 3 months; who use anticoagulant and platelet antiaggregant; with dental implants; with glycated hemoglobin greater than or equal to 9% and/or fasting glucose greater than or equal to 250mg/dl; who change their diabetes medication during the study period; under 30 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-4bdwxs	Effect of green tea and metformin on excess of sugar on the blood of obese individuals with pre-diabetes	Recruitment completed	Intervention	2015-07-25	<NULL>	<NULL>	556	Effect of green tea extract and metformin on insulin resistance in obese individuals with pre-diabetes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-15	CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Faculdade de Nutricao (FANUT/UFG)	https://ensaiosclinicos.gov.br/rg/RBR-4bdwxs	<NULL>	Obese individuals (fat&gt; 30%) with pre-diabetes, women, aged 20-60 years.	Volunteers with thyroid disorders; diabetes; renal and hepatic diseases; pregnant women; nursing; in hormone replacement; under treatment for weight control; those who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-8z4ctxq	Effect of green tea gel and hyaluronic acid on healing after wisdom teeth extraction	Not yet recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5079	Effect of green tea and hyaluronic acid gel on the healing of post-extraction sites of third molars a split-mouth randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8z4ctxq	<NULL>	Over 18 years of age; Have good oral hygiene (Plaque Index &lt; 20%); Presence the four third molars; Have indication for tooth extraction of all third molars	Patients with periodontal disease; Patients with systemic diseases or conditions or who use medications that alter bone metabolism (except diabetics); Decompensated diabetics (glycated hemoglobin above 8%); Pregnant or lactating women; Heavy smokers (above 10 cigarettes a day); Presence of periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-23nf3s	Effect of group vaginal muscle training in  post-menopausal women	Data analysis completed	Intervention	2014-05-07	<NULL>	<NULL>	291	Effect of a group pelvic floor muscle training in climateric and post-menopausal  women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-14	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-23nf3s	<NULL>	Post-menopausal women  for at least 5 years; with complaints from urogynecological symptoms; participants of Physical Activity in Congonhal&apos;s City.	women with vaginal or urinary infections; pelvic cancer; uncontrolled metabolic disorders (hypertension and diabetes); cognitive, psychiatric or neurological disorder; chronic vaginal pain; inability to contract the pelvic floor muscles (PFM); pelvic organ prolapse stage IV according to the Pelvic Organ Prolapse Quantification System (POP-Q) and severe heart disease , who added up to four volunteers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-3vzsyqq	Effect of Groups to the treatment of Obesity	Recruiting	Intervention	2021-05-29	<NULL>	<NULL>	6064	Effectiveness of a Collective Intervention to the management of Obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-3vzsyqq	<NULL>	Being 20 years or more; having obesity without indication for bariatric surgery; being frequent in Program&apos; activities (that is, participation in at least one exercise class in the month before the begging of data collection); having desire and willingness to participate in groups on six months or more; and being in the stages of change from &quot;preparation with high self-efficacy&quot; or &quot;action&quot; or &quot;maintenance&quot; to reduce body weight	Being pregnant and/or having cognitive difficulties that make impossible to answer the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-86wzhcr	Effect of guidelines on Eating Behavior and Sleeping Patterns of shift workers: a study with Military Police officers from the 18th BPM – Catalão/GO	Recruitment completed	Intervention	2023-10-19	<NULL>	<NULL>	6522	Effect of Nutritional Counseling and Sleep Hygiene on the Eating Behavior and Sleeping Pattern of shift workers: a clinical case study of Military Police officers assigned to the 18th BPM – Catalão/GO	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-08	Universidade Federal de Catalão	18º Batalhão de Polícia Militar do Estado de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-86wzhcr	<NULL>	Belonging to the 18th Battalion of the Military Police of the State of Goiás (18th BPM), carrying out its activities on a 24/72 hour duty schedule; Be a member of active military police; Age over 18 and under 60 years old; You have an active WhatsApp® application on your cell phone	During the research, you are removed from your duties for reasons not controlled by the research; Have a diagnosis of chronic complications such as kidney failure, blindness, limb amputation, among others	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-777nzpz	Effect of Gum Treatment in Diabetic Patients	Recruiting	Intervention	2024-07-24	<NULL>	<NULL>	7158	Impact of Periodontal Disease and the Expression of Cytokines Associated with T Helper 17 and Regulatory T Cells on the Metabolic Control of Patients with Type 2 Diabetes Mellitus	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-30	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-777nzpz	<NULL>	Patients aged ≥ 30 and ≤70 years; Diagnosis of periodontitis according to the classification of periodontal conditions and diseases with interproximal clinical attachment level (CAL) ≥ 2 or CAL≥ 3 mm in more than 2 non-adjacent teeth (excluding the CAL limits cited in cases related to periodontitis: gingival recession of origin traumatic; dental cavities extending into the cervical area of ​​the teeth; presence of CAL in the distal part of the second molar and associated with poor dental position or extraction of the third molar; endodontic lesion reaching the gingival margin and occurrence of vertical root fracture. Participants should also present at least 4 sites with probing depth (PD) ≥4mm with bleeding on probing (BP); present at least 15 teeth, excluding third molars and be diagnosed with type 2 diabetes mellitus (DM2) (HbA1c &gt; 6.5% ) in the DM2 group and absence of DM2 diagnosis (HbA1c ≤ 6.5%) in patients in group P	Received prior non-surgical periodontal treatment within 6 months of the study; Had used antibiotics and anti-inflammatories within three months before the start of the study; Women were pregnant or breastfeeding; Use of immunosuppressants and/or have blood disorders; Were undergoing orthodontic treatment; If they needed prophylactic antibiotic therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-9d78qy	Effect of gum treatment in hypertensive patients	Not yet recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3253	Effect of non-surgical periodontal Treatment in patients with periodontitis and Refractory Arterial Hypertension	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-20	Faculdade de Odontologia de Araçatuba FOA	Faculdade de Odontologia de Araçatuba FOA	https://ensaiosclinicos.gov.br/rg/RBR-9d78qy	<NULL>	Patients over 35 years old; Have at least 12 teeth present; Diagnosis of generalized periodontitis according to periodontal classification: insertion loss in 2 non-adjacent interproximal sites, clinical insertion loss (CIN) greater than or equal to 3mm in 2 teeth, except for: gingival recession, dental caries, endoperiodontal injury, occurrence root fracture, presence of loss of insertion in the distal face of a second molar and associated with poor positioning or extraction of the third molar; a gingival condition would be described as localized when less than 30% of the teeth are affected; greater than 30% of teeth are affected by periodontal disease; Patients diagnosed with major refractory arterial hypertension equal to 140 and / or 90mmHg.	Smokers or former smokers less than 12 months old; Patient with anemia; Active cancer patient; Patient with blood disorders; Pregnancy; Patient with chronic kidney disease; Patient with decompensated Type II Diabetes Mellitus; Bacterial endocarditis; Having received some kind of prior periodontal therapy; Patient using any medication such as antibiotic or anti-inflammatory and systemic conditions that affect the progression or periodontal treatment; Patient undergoing chemotherapy and / or head and neck radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-10vf2byw	Effect of Gum Treatment on saliva and gingival fluid proteins in people with type 2 Diabetes	Not yet recruiting	Intervention	2026-05-09	<NULL>	<NULL>	9186	Effect of Periodontal Treatment on the proteomic profile of saliva and gingival fluid in type 2 diabetic patients with Periodontitis	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-02	Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	individuals over 30 years of age; with stage III-IV periodontitis; who provide saliva samples of at least 1 ml; who provide complete information on health-related issues; who have at least 15 teeth in their mouth; a minimum of 4 functional teeth and at least 3 adjacent teeth with interproximal papilla in at least one posterior quadrant of the maxilla; and who are able to read, understand, and sign an informed consent form.  For participants with diabetes mellitus, the inclusion criterion will be a minimum of 1.5 years since diagnosis	Smokers and former smokers who quit smoking less than 5 years ago, pregnant women, individuals who have undergone periodontal treatment in the last year, undergone antibiotic or anti-inflammatory therapy 3 months prior to inclusion in the study, or who have any other systemic disease, other than type 2 diabetes mellitus, that may alter the course of periodontal disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-9kv6mqc	Effect of healthy habits on cardiovascular risk factors in patients with Ischemic Stroke or Transient Ischemic Attack	Recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8120	Effect of healthy habits on cardiovascular risk factors in patients with Ischemic Stroke or TIA: a randomized study according to AHA Life’s Essential 8 health indicators	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-19	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9kv6mqc	<NULL>	Patients diagnosed with Ischemic Stroke or Transient Ischemic Attack (TIA) within the past 48 hours, with a modified Rankin score less than 2; aged 18 years or older; of both sexes; and with a signed informed consent form	Patients with severe chronic diseases that may interfere with the study (e.g., active cancer, advanced renal failure); severe psychiatric disorders; and/or inability to participate in educational and follow-up sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-3ht499	Effect of heparin to prevent obstruction of the Hickman® catheter	Recruiting	Intervention	2017-07-03	<NULL>	<NULL>	1274	Effectiveness of heparin solution in preventing Hickman® catheter occlusion: clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-22	Hospital de Clínicas Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3ht499	<NULL>	Being hospitalized in the research unit; Have indication of implantation of Hickman® semi-implantable central venous catheter; Insertion of the Hickman® semi-implantable central venous catheter into the research unit or use of the first Hickman® semi-implantable central venous catheter in the research unit; First hospitalization for transplantation of stem cells in the bone marrow transplantation service in the complex of clinics of the Federal University of Paraná.	Being on anticoagulant by any route of administration; Being in fibrinolytic therapy; Present a history of allergy to heparin components; Bleeding during the period of data collection; Be refractory to platelet transfusion; Have had previous hospitalization in the research unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-5328h8g	Effect of high and low volume of specific training for the trunk in chronic low back pain	Not yet recruiting	Intervention	2022-05-13	<NULL>	<NULL>	5394	Neuroimmunoendocrine effects of core stabilization training in women with chronic non-specific lumbar pain: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5328h8g	<NULL>	Women with a clinical diagnosis of chronic nonspecific low back pain; age between 18 and 59 years; complaint of low back pain for more than 3 months; pain level greater than 3 on the 11-point numerical pain scale; body mass index (BMI) &lt;30 kg/m2; not having undergone spinal surgery; not practicing physical exercise regularly; not having physical therapy or other pain treatment; not taking analgesic, anti-inflammatory, opioid or immunosuppressive medication	Missing one of the assessments; missing more than 10% of the intervention; have any motor, psychiatric or cognitive impairment; have hearing, visual or communication disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-5mr2zq	"Effect of high folic acid levels on enzymes activity and its relation with
expression of genes related to folate metabolism"	Recruiting	Intervention	2017-03-27	<NULL>	<NULL>	1194	"Effect of high folic acid levels on DHFR activity and its relation with
mRNA expression of genes related to folate metabolism and inflammatory cytokines"	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-11-01	CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5mr2zq	<NULL>	For the group of non-pregnant women with a history of primary miscarriage: women aged 18-40 years; at least two histories of recurrent spontaneous miscarriage; no viable fetus; in use of 5 mg of folic acid daily. For the prospective study with intervention of 5 mg of folic acid per day: healthy volunteers; both sexes, from 18 to 45 years, non smokers.	Women with a history of abortion who are pregnant during study enrollment. For the study with intervention of 5 mg of folic acid per day will be excluded chronic alcoholics; patients with chronic diseases; pregnant women; smokers; individuals who underwent major surgery to less than 6 months or donated blood in the last 3 months; and Those who have used polivitamins in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-76yd7ph	Effect of high intensity interval training on 24-Hour Central Pressure	Not yet recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8596	Effects of different types of physical exercise on blood pressure, arterial pressure, and indicators of sarcopenia in hypertensive adults and elderly individuals	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-06	Centro de Ciências da Saúde da Universidade Estadual de Maringá	<NULL>	<NULL>	<NULL>	Age between 40 and 79 years; clinical diagnosis of stage I or stage II systemic arterial hypertension confirmed by ambulatory blood pressure monitoring performed within the last six months; regular use of antihypertensive medication; physical and cognitive ability to perform the exercise protocols; signed informed consent form	Inability or refusal to sign the informed consent form; myocardial infarction; revascularization procedures; deep vein thrombosis; stroke or pulmonary embolism in the last twelve months; chronic heart failure class III or class IV according to the new york heart association classification (nyha); unstable arrhythmia; chronic obstructive pulmonary disease requiring corticosteroid therapy or oxygen therapy; renal disease under dialysis treatment; progressive neurological disorders such as parkinson disease or multiple sclerosis; cancer under treatment in the last two years; participation lower than seventy five percent of exercise sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-2fdkw3	Effect of high intensity interval training on physical capacity, body composition, quality of life and autonomic cardiac control of hypertensions	Recruiting	Intervention	2018-12-20	<NULL>	<NULL>	4586	Effect of high intensity interval training on physical capacity, body composition, quality of life and autonomic cardiac control of hypertensions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade de Pernambuco (UPE)	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-2fdkw3	<NULL>	Volunteers with essential hypertension classified as borderline or stage I diagnosed for at least 12 months; both sexes; age between 18 and 60 years; in use of optimized drug therapy; without contraindications to physical exercise.	Ethnic volunteers; smoking; diagnoses of other cardiovascular diseases; diagnosis of COPD; diagnosis of occidentalomuscular diseases that prevent exercise; pregnant women; volunteers who practice physical activity regularly in the three months prior to the study; does not make use of optimized medicine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-4qcx7g3	Effect of High Intensity Training on immune and cardiovascular responses in people living with HIV	Recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6376	Acute effect of High Intensity Interval Training on immunological parameters, risk of infection and cardiac autonomic control of people living with HIV: A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4qcx7g3	<NULL>	Men with HIV who have started antiretroviral therapy for at least 6 months; medical certificate releasing the practice of physical exercise; age between 18 and 40 years; physically active; and cell count of T lymphocytes cluster of differentiation 4 (T CD4) above 350 cells/mm³. For subjects without HIV, all criteria for people living with HIV will be used, with the exception of antiretroviral therapy and presence of HIV	People with HIV who have some musculoskeletal limitation that prevents them from carrying out the exercise; cardiovascular diseases; illicit drug users and/or smokers; alcoholics; do not comply with recommendations for carrying out assessments; and who do not complete the experimental protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-5hkrss	Effect of high-voltage electrical stimulation after carpal tunnel syndrome surgery	recruitment completed	Intervention	2012-02-01	<NULL>	<NULL>	80	Effects of high voltage eletrical stimulation on pain and disfunction in workers with carpal tunnel syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-21	Faculdade de Ciências da Saúde - UNIMEP	Faculdade de Ciências da Saúde - UNIMEP	https://ensaiosclinicos.gov.br/rg/RBR-5hkrss	<NULL>	Female patients, aged between 20 and 60 years, after surgery for carpal tunnel decompression	"Be doing physical therapy at another location; 
miss two or more intervention sessions, without replacement of the lost session."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-5g9n5g	Effect of hip muscle strengthening in patients with Osteoarthritis of the knee.	Recruitment completed	Intervention	2018-02-02	<NULL>	<NULL>	1621	Efficacy of the strengthening of the postero lateral lateral musculature of the hip in individuals with osteoarthritis of knee.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade São Judas Tadeu	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5g9n5g	<NULL>	Healthy volunteers; both genders; age between 50 and 90 years; present a medical report or radiographic evidence of OA according to the Kellgren and Lawrence scale; knee pain over the last week, be physically independent.	To present pathologies in incapacitating levels; having a diagnosis of fibromyalgia or rheumatoid arthritis; use of corticosteroid or intra-articular hyaluronic acid in the last 12 months; oral use of anti-inflammatory drugs last 2 months; participation in a neuromuscular strengthening or exercise program or other (non-pharmacological) treatment for knee OA in the last six months; prosthesis or any other surgery on the hip and knee joints; decompensated heart diseases; hearing or visual impairment. Participants were asked to refrain from seeking other forms of treatment during the exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-3337xv9	Effect of Hippotherapy on biopsychomotor and functional skills in children and adolescents with Autism Spectrum Disorder: a cohort study	Data analysis completed	Observational	2025-12-04	<NULL>	<NULL>	8618	Equine therapy in Brazil: an epidemiological survey and its contributions to Autism Spectrum Disorder.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Campina Grande (UFCG), Centro de Tecnologia e Saúde Rural, Programa de Pós-Graduação em Ciência e Saúde Animal (PPGCSA).	<NULL>	<NULL>	<NULL>	Children and adolescents with a primary diagnosis or clinical history of ASD (Autism Spectrum Disorder); aged between 2 and 18 years; able to understand simple instructions; available to participate in the equine therapy program once a week.	Participation in other research related to horses; prior experience with equine therapy; presence of other neurological, psychiatric, or genetic diagnoses, such as comorbidities or disorders secondary to ASD (Down syndrome with ASD, bipolar disorder or schizophrenia associated with ASD and/or cerebral palsy with clinical signs of ASD); and lack of authorization from the medical or multidisciplinary team to perform equine therapy.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-9tnwp85	Effect of home Eletric Stimulation on pain in Rheumatoid Arthritis patients with low inflammation	Recruiting	Intervention	2023-06-20	<NULL>	<NULL>	6163	Effect of home Direct Current Transcranial Stimulation on pain in Rheumatoid Arthritis patients with low inflammatory activity: a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-24	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9tnwp85	<NULL>	Participants aged 18-70 years from the arthritis clinic will be included rheumatoid disease at the Hospital de Clínica de Porto Alegre (HCPA) who fulfill the following criteria:Participants diagnosed with RA according to the 2010 American criteria College of Rheumatology and the European League Against Rheumatism and determined by the clinical evaluation of a certified rheumatologist; Participants with RA and generalized pain for more than 3 months that is not of character mechanical or inflammatory, evaluated by a certified rheumatologist;Participants with pain assessed by the EVA-D visual analogue scale with a higher value than 40mm (moderate to severe pain) reported by the participant and/or recorded in the last consultations within the 3-month period prior to inclusion; Inflammatory Tests CRP less than 0.5 mg/dl and ESR less than 15 mm/h in the last exams performed in the 3-month period prior to inclusion; Treatment for stable RA, defined as unchanged doses of NSAIDs and/or opioids and/or DMARD in the 6 months prior to the start of the study protocol and doses of prednisone less than or equal to 5mg per day in the 6 months preceding the study; Stable treatment of antidepressants or anticonvulsants if using them for the treatment of pain, defined as no dose changes in the 6 months that precede the study; Possibility of maintaining doses of NSAIDs, DMARDs, corticosteroids, antidepressants and anticonvulsants without changes during the study; Being right-handed; Ability to give informed consent	Having contraindications for the use of Transcranial Direct Current Stimulation (tDCS): history of brain surgery, history of traumatic brain injury, history of stroke, previous implantation intracranial of any type of metal, pregnant or breastfeeding; Have a previous history of an autoimmune disease other than rheumatoid arthritis, fibromyalgia and osteoarthritis; Have a previous history of neurological disease; Have a previous history of neoplasia; Have a previous history of any other uncompensated medical illness (heart disease,kidney disease, liver disease, etc.); Use of illicit drugs in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-85tmk64	Effect of homeopathic medicines for the treatment of Smoking	Data analysis completed	Intervention	2025-12-01	<NULL>	<NULL>	8601	Effect of Hetero-isotherapics for the treatment of Smoking	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2017-07-26	Faculdade de Farmácia da Universidade Federal do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Smoking participants; at least 18 years old; both sexes; who wish to give up the habit of smoking; participant must be a current smoker, which is someone who smokes daily or occasionally	Not be a smoker. Just be a passive smoker. Be an ex-smoker. Be under 18 years old. Participants who are included in the research, but refuse to adequately respond to the Follow-up questionnaire or do not attend monthly evaluation meetings with the team. People who have not smoked for at least 1 month (ex-smokers) or who do not smoke or who are passive smokers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-5jnbyhk	Effect of hospitalization on nutritional status and risk of dysphagia in people older than 65 years of age	Not yet recruiting	Observational	2022-01-03	<NULL>	<NULL>	5133	Impact of hospitalization on nutritional status and the risk of dysphagia in people aged 65 years. Multicentre study &quot;NUTRIFAG&quot;	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Department of Nursing, University of Alicante, Alicante Institute for Health and Biomedical Research (ISABIAL),	Universidad de Alicante	https://ensaiosclinicos.gov.br/rg/RBR-5jnbyhk	<NULL>	patients 65 years of age or older; hospitalized in medical or surgical units; admitted for more than 48 hours; informed consent of the patient or legal guardian	patients with enteral or parenteral nutrition on admission; terminally ill patients or patients with a primary diagnosis of cancer; patients admitted to critical care units	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-4qpj2r	Effect of Human Ration on Weight Loss and Bone Health in Overweight Women	Data analysis completed	Intervention	2013-04-02	<NULL>	<NULL>	176	Effect of Human Ration in Weight Loss and in Bone Health in Overweight Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-4qpj2r	<NULL>	Female gender. IMC higher than 25 and less than 34.9 kg/m2 and age between 24 and 45 years.	Pregnant or breastfeeding women. Menopausal women or who underwent removal of the uterus. Which used anti-inflammatories. Who presented intolerance or allergy to any ingredient in the product. Which drink´s alcohol or smokes. Who were using the drug for inhibiting appetite. Antidepressants or whatever to interfere in bone mineral metabolism (bisphosphonates, anabolic steroids, calcitonin, fluoride, hormone replacement therapy, androgens, calcium, vitamin D, thiazide diuretics, and statins). Women with a history of conditions or diseases associated with changes in bone mass such as kidney disease (cholelithiasis, chronic renal failure), gastrointestinal disease (celiac disease, chronic liver disease, malabsorption syndrome, gastrectomy or colectomy). History of endocrine disease (hyperparathyroidism, hyperthyroidism or hypothyroidism). Fractures in the last six months. Which had shown restraint for more than two months and showed fluctuations in body weight greater than 5% in the two months before recruitment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-8t6qj75	Effect of Hyaluronic Acid Injection in the subtalar joint of patients with Osteoarthritis	Recruitment completed	Intervention	2023-09-09	<NULL>	<NULL>	6417	Functional evaluation of the results of the Hyaluronic Acid Injection in the subtalar joint in patients with post-traumatic Osteoarthritis who underwent Osteosynthesis of the calcaneus with a Kirschner wire	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-18	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	https://ensaiosclinicos.gov.br/rg/RBR-8t6qj75	<NULL>	Patients of both genders; who underwent intra-articular infiltration for the treatment of symptomatic subtalar osteoarthritis secondary to calcaneal fracture at the National Traumatology and Orthopedics Institute between 2017 and 2018 (at the time of the trauma, all patients were treated with osteosynthesis of the calcaneus with a Kirschner wire, a standard treatment at the foot service and ankle of the Institution); and who were selected to participate in a study to evaluate the outcomes of subtalar osteoarthritis after intra-articular injections	Patients with subtalar ankylosis; previous infection; radiographic parameters compatible with inadequate joint reduction; hypersensitivity to hyaluronic acid; pregnancy and breastfeeding; concomitant diseases affecting the joint; open wound or ulcer; use of anticoagulants or altered bleeding time; intra-articular injection or arthroscopy less than 6 months; and patients undergoing subtalar arthrodesis and, therefore, they did not participate in the initial study with a follow-up of 6 months after intra-articular injections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-78tbws	Effect of hydration on the mechanisms responsible for changes in blood pressure  after one session of aerobic exercise.	Recruiting	Intervention	2013-08-13	<NULL>	<NULL>	226	Effect of hydration on blood pressure response after exercise and its mechanisms.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78tbws	<NULL>	"Healthy men
Sedentary
Aged 18 to 35 years"	"Individuals trained
Hypertension (systolic and diastolic blood pressures greater than or iqual to 130/85 mmHg)
Obesity (body mass index greater than or equal to 30kg/m2)
Smokers
Diabetes (fasting glucose greater than or equal to 126 mg / dl)
Heart diseases (previous diagnosis or change in rest or exercise ECG)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-9zn52b	"Effect of hydrotherapy compared with decongestive complex therapy for reduction of
lymphedema in lower limb"	Recruiting	Intervention	2020-01-06	<NULL>	<NULL>	3332	"Effect of hydrotherapy compared with decongestive complex therapy for reduction of
lymphedema in lower limb"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-30	Faculdade de fisioterapia da Universidade Federal de Pernambuco	Faculdade de fisioterapia da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9zn52b	<NULL>	Lower limb lymphedema	Use of topical antifungal and prophylactic antibiotics for secondary infections; infectious processes active and not treated during the project; thrombophlebitis; active neoplasms at the site of drainage, cellulitis, deep venous thrombosis in the acute phase, cardiac, hepatic and renal decompensations, and uncontrolled hypertension; significant lower limb arteriopathies and neoplastic degeneration of lymphedema.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4ymcyc	Effect of hydroxyapatite paste on human enamel	Recruitment completed	Intervention	2015-09-16	<NULL>	<NULL>	615	In vitro and in situ effects of nano hydroxyapatite in bleached enamel with hydrogen peroxide	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-03	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-4ymcyc	<NULL>	3 persons aged between 20 and 22 years; Height of the clinical crown of the upper molars above 5 mm; absence of cavities; absence of periodontal disease; normal oral pH around 7.0; normal salivary flow.	Patients with dentin sensitivity; gastroesophageal disturbances; pregnant or nursing women; patients with fixed prostheses or removable orthodontic appliances; drug users or smokers; and practitioners of water sports.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-53643h8	Effect of Hygiene Devices on the healing of Inflammation around dental implants	Not yet recruiting	Intervention	2022-09-26	<NULL>	<NULL>	5639	Effect of Hygiene Devices on the healing of Peri-implant Mucositis lesions: a parallel randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-53643h8	<NULL>	Age greater than or equal to eighteen years; Implants in function for more than a year; Diagnosis of peri-implant mucositis, defined as: Presence of visual signs of peri-implant inflammation combined with profuse bleeding on probing (line or drop) and/or suppuration at two or more sites, probing depths of four to five mm and no detectable bone loss	Absence of adjacent teeth; No contact point with adjacent teeth; Implants diagnosed with peri-implantitis; Patients in which the Curaprox IAP Probe cannot be used due to lack of space; Full-arch or removable implant-supported rehabilitation; Fixed implant-supported rehabilitation (multiple prosthesis); Implants with inadequate hygiene access or marginal misfit; Individuals with limited manual dexterity, making self-administered implant hygiene impossible; Presence of active periodontal disease; Heavy smokers; Patients with transmissible diseases or critical medical conditions such as, but not limited to: uncontrolled diabetes, AIDS, bone disease and rheumatic fever; Conditions requiring prophylactic antibiotic coverage prior to dental treatment; Pregnancy or breastfeed; Any known allergies to the components of the supplied products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-92vxxk6	Effect of Hyperbaric Oxygen Therapy (OHB) in patients hospitalized by COVID-19	Recruiting	Intervention	2021-08-16	<NULL>	<NULL>	4837	Randomized controlled clinical trial on the effect of Hyperbaric Oxygen Therapy (HBO) in non intubated COVID-19 hospitalized patients	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-05-24	Hospital Risoleta Tolentino Neves	Ecotec Equipamentos e Sistemas Eirelli	https://ensaiosclinicos.gov.br/rg/RBR-92vxxk6	<NULL>	Patients over 18 years of age; diagnosis confirmed by laboratory tests or computed tomography (CT) of the chest compatible with COVID-19; oxygen saturation below 93% in ambient air; respiratory frequency greater than or equal to 24 resp / min; without a significant commitment from other bodies or systems.	Hemodynamic instability, defined by mean arterial pressure less than 60 mmHg; respiratory failure requiring intubation; blood levels of TGO/TGP greater than 5 times the upper limit of normal; several chronic kidney diseases in stage 4; kidney disease requiring dialysis, that is, with eGFR (Estimated Glomerular Filtration Rate) less than 30 mL/min; transition planned to another hospital, other than a place of study, within 72 hours; infection with the human immunodeficiency virus under highly active antiretroviral therapy (HAART); history of severe depression or attempted suicide or current suicidal ideation; contraindications related to the administration of hyperbaric oxygen: pregnancy; breast-feeding; untreated pneumothorax; use of adriblastine, cisplatin, doxorubicin and mafenide; topical use of iodine and / or petrolatum; advanced emphysema with CO2 retention; claustrophobia; other conditions identified by the hyperbarist team.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-48c9xt	Effect of ibuprofen + caffeine administration on the reduction of dental sensitivity from in-office bleaching	Data analysis completed	Intervention	2018-08-28	<NULL>	<NULL>	4344	Effect of anti-inflammatory administration on the reduction of dental sensitivity from in-office bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-48c9xt	<NULL>	Patients will be included who are older than 18 years of age with good oral and general health; have their maxillary anterior teeth free from restorations and carious lesions; with color A2 or darker according to the Classical Vita scale (Vita Zahnfabrik, BadSäckingen, Germany); and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening; pregnant patients or lactating; severe browning (staining by tetracycline; fluorosis or endodontics); people with dental prostheses and orthodontic appliances and any other oral pathology. Patients will be excluded that present changes stomach; heart; kidney and liver problems; diabetes; hypertension or are making continual use of drugs with analgesic and anti-inflammatory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-8skkj7q	Effect of Ibuprofen and Arginine gel on sensitivity after whitening: controlled clinical study	Recruitment completed	Intervention	2025-05-05	<NULL>	<NULL>	7983	Desensitizing action of topical application of Ibuprofen and Arginine gel on post-whitening sensitivity: a randomized, double-blind, split-mouth clinical study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-01-01	União Educacional de Cascavel	FGM Dental Group	https://ensaiosclinicos.gov.br/rg/RBR-8skkj7q	<NULL>	Patients of both sexes; aged between 18 and 30 years; presence of all vital anterior teeth; never having undergone dental whitening; not having restored anterior teeth; not having central incisor teeth with color A2 or darker	Patients with missing front teeth; with caries lesions; presence of gingival recession; with any restorative or prosthetic treatments; history of dental hypersensitivity; dental discoloration due to Tetracycline or Fluorosis; who use continuous medications such as anti-inflammatories and analgesics; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-2rgxbdv	Effect of Immunological Reactions of Dexmedetomidine when used in patients undergoing Video-Assisted Gallbladder Removal	Data analysis completed	Intervention	2022-03-28	<NULL>	<NULL>	5833	Immunomodulatory effect of Dexmedetomidine as an adjuvant drug in patients undergoing laparoscopic Cholecystectomy	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2022-04-01	Gustavo Nascimento Silva	Hospital Universitário Gaffree e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-2rgxbdv	<NULL>	Patients classified as physical health status 1 and 2; Laparoscopic Cholecystectomy Surgery; Patients who signed the Free and Informed Consent Form	Patients classified as physical health status more than 2 ;Conversion to open surgery;Emergency Surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-72kd57	Effect of impact home based exercises to people with Down syndrome	Data analysis completed	Intervention	2019-12-19	<NULL>	<NULL>	3300	Effect of home based exercises to people with Down syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72kd57	<NULL>	"Have clinical and laboratory diagnosis of DS;Be in follow up in the Rehabilitation Program for people with DS of IMREA HCFMUSP Lucy Montoro;
18 to 35 years old; Preserved mobility;Normal cardiorespiratory test"	"Current heart disease;Atlantoaxial subluxation;
Severe intellectual disability;Orthopedic problems;Neurodegenerative and musculoskeletal diseases"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8m47vs	Effect of in-office dental bleaching with  violet light	Recruitment completed	Intervention	2020-04-30	<NULL>	<NULL>	3792	Effectiveness, longevity and sensitivity of in-office dental bleaching with the use of violet light: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-05	Universidade de Pernambuco	Faculdade de Odontologia de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8m47vs	<NULL>	"Both gender;
Aged between 18 and 35 years old;
Who have good overall and oral health;
Caries-free upper anterior teeth;
Absence of cervical lesions;
Absence of restorations on the buccal surface;
Periodontal health must be preserved;
Center incisors should be C2 or darker according to a value oriented color scale (Vita Lumin, Vita Zahnfabrik, Bad Säckingen, Germany)"	"Aprenda a pronunciar
Participants with previous pre-existing restorations;
Pregnant / lactating women;
Teeth with severe discoloration
Those who have drugs with habits;
Use of anti-inflammatory drugs;
Bruxism or any other condition that may cause dentin sensitivity;
Smokers;
That have undergone some kind of whitening treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-3m7fdv	Effect of individual and group exercise on pain and fatigue caused by cancer	Recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2075	Effect of individual or collective kinesiotherapy on pain and oncological fatigue	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-20	Universidade Federal de Sergipe	Associação de Amigos da Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-3m7fdv	<NULL>	Anatomopathological diagnosis of breast cancer; radical or total mastectomy surgery; have or have not had adjuvant chemotherapy; removed from the drain; have up to four months of performing the surgical procedure; surgical incision healed.	Malnutrition; metastasis; lymphedema; bilateral breast cancer; immediate breast reconstruction; had adjuvant radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-2sn8xv	Effect of individual sound amplification apparatus and/or Ginkgo blloba in tinnitus.	Data analysis completed	Intervention	2018-11-07	<NULL>	<NULL>	2317	Efficacy of the individual hearing aid x drug interaction with Ginkgo biloba in patients with Hearing Loss and Tinnitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Anhanguera de São Paulo	Clínica da Audibel Aparelhos Auditivos	https://ensaiosclinicos.gov.br/rg/RBR-2sn8xv	<NULL>	The inclusion criteria of the patients were: individuals over 18 years of age; complaint of tinnitus (uni or bilateral) for at least three months; (single or bilateral) sensorineural or mixed hearing loss independent of degree and configuration; both male and female were recruited.	The exclusion criteria of the patients were: have used aspirin or acetylsalicylic acid (ASA) in the last month; have used of Ginkgo biloba in the last three months; on antidepressant use; with compromised middle ear (otitis or tubal dysfunction) at the time of evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-5jrdd7c	Effect of Infant Massage on premature babies admitted to the hospital	Recruiting	Intervention	2024-12-10	<NULL>	<NULL>	7584	Effect of Therapeutic Infant Massage on premature babies admitted to the care unit neonatal intermediates	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-04	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-5jrdd7c	<NULL>	Gestational age between 32 and 36 weeks; birth weight greater than or equal to 1500 grams;  hospitalization in the Neonatal Intensive Care Unit - NICU; clinical stability; chronological age between 3 and 28 days; both genders; and authorization from parents/guardians through the Informed Consent Form -  ICF	Newborns who, during the research, present hemodynamic instability, reaction allergic to vegetable oil, need for emergency surgery; if discharged before the end of the research; if transferred to another hospital; if the person responsible decides to discontinue participation in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-4hcvsg	Effect of infrared laser after office bleaching to reduce dental sensitivity	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2697	Effect of low power laser for reduction of bleaching-induced tooth sensitivity after in-office bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4hcvsg	<NULL>	Patients older than 18 years of age. Male and female. With good general and oral health. Teeth free of caries lesions. Have teeth in color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and that they agree with the informed consent term (TCLE).	Will be excluded volunteers who have already undergone dental bleaching. Who have dental prosthesis; previous dental sensitivity; severe dental dimming by pathologies or medications; fixed orthodontic appliance. Who are pregnant or breastfeeding and who are making continuous use of some medicine that reduces the sensitivity dental.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-6n573b	Effect of Infrared LEDs compared to Respiratory Therapy Maneuvers in the Treatment of Community Pneumonia	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2714	Comparison of Infrared LED with Respiratory Physiotherapy Maneuvers in the Treatment of Community-Acquired Pneumonia	<NULL>	2, non-randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-05-01	Centro Universitário de Itajubá	PÂMELA CAMILA PEREIRA	https://ensaiosclinicos.gov.br/rg/RBR-6n573b	<NULL>	Participants aged 55-85 years; with a clinical diagnosis of community-acquired pneumonia (Streptococcus pneumoniae); undergoing conventional respiratory physiotherapy treatment; on oxygen therapy up to 1 L/minO2 and on antibiotic therapy (azalides, cephalosporins, fluoroquinolones); both sexes	Patients diagnosed with fungal and viral pneumonia; with hospital-acquired pneumonia (those hospitalized for more than 2 days in the previous 90 days); institutionalized; overweight (Body Mass Index – BMI: above 29.9 kg/m2); who do not sign the Informed Consent Form; who do not belong to the stated age range; who have neoplasms and a history of photosensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:08
RBR-7gwwxzg	Effect of infrared light on chronic renal patients undergoing hemodialysis and conservative treatment	Recruitment completed	Intervention	2025-01-07	<NULL>	<NULL>	7642	Effect of photobiomodulation with infrared led in chronic renal dialysis and non-dialysis patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Anhembi Morumbi	Hospital Regional do Baixo Amazonas Dr. Waldemar Penna	https://ensaiosclinicos.gov.br/rg/RBR-7gwwxzg	<NULL>	chronic kidney disease, male and female, age between 25 and 75 years, total number of patients 24	under 18 and over 80 years of age, debilitated, who do not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-33wf46	Effect of ingestion of yacon syrup in human	Not yet recruiting	Intervention	2018-03-12	<NULL>	<NULL>	1684	Metabolic benefits of nutraceuticals in human health	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Fundação Universidade Estadual do Ceará FUNECE	Empresa Brasileira de Pesquisa Agropecuária	https://ensaiosclinicos.gov.br/rg/RBR-33wf46	<NULL>	Women; between 20 and 40 years old; do not present chronic self-reported diseases; have a body mass index of eutrophy or obesity grade I; regular menstrual cycle.	Pregnancy or lactation; hysterectomy performed; current smoker or in the last 30 days; users of illicit drugs; daily consumption of ethanol higher than 15g; current or last 30 days use of hypoglycemic, lipid-lowering, antibiotic and anti-inflammatory medications, laxatives or weight-loss medications; have inflammatory diseases such as inflammatory bowel disease (Crohn&apos;s disease, ulcerative colitis); endocrinopathy carrier’s (cushing&apos;s syndrome, hypothyroidism), cancer carrier’s, having celiac disease or lactose intolerance; have constipation history; present current consumption and in the last 30 days of fiber and fructooligosaccharides supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-8nfx26	Effect of Inhaled Nitric Oxide for the treatment of COVID-19	Not yet recruiting	Intervention	2020-09-22	<NULL>	<NULL>	4770	Inhaled Nitric Oxide for Treatment of SARS-CoV-2 Infection: An Open-Label, Multicenter, Parallel, Randomized Controlled Trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2021-07-10	Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-8nfx26	<NULL>	"Protocol A
Hospitalized patients with proven or high suspicion of coronavirus infection; signing a consent form and/or assent; older than 10 years. Score clinical 4 (receiving supplemental oxygen).

Protocol B
Non hospitalized patients with proven or high suspicion of coronavirus infection; signing a consent form and/or assent; older than 10 years. Score clinical 2 (at home with limitations)."	"Protocol A
Participant in any other clinical trial of an experimental treatment for COVID-19; pregnancy; clinical contraindication of the attending physician; use of a nitric oxide donor agent, such as nitroglycerin or drugs known to increase methaemoglobin, such as lidocaine, prilocaine, benzocaine or dapsone; heart failure, left ventricular dysfunction; history of hemoptysis. 

Protocol B
Participant in any other clinical trial of an experimental treatment for COVID-19; Pregnancy; clinical contraindication of the attending physician; indication for hospitalization at the time of evaluation; use of a nitric oxide donor agent, such as nitroglycerin or drugs prepared by increasing methemoglobin, such as lidocaine, prilocaine, benzocaine, or dapsone; heart failure, left ventricular dysfunction; hx of hemoptysis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-627wc4w	Effect of injections in the treatment of Tennis Elbow	Recruitment completed	Intervention	2026-01-05	<NULL>	<NULL>	8690	Relative efficacy of peritendinous injections for the treatment of lateral epicondylitis of the elbow - a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-10	Universidade de Taubate	<NULL>	<NULL>	<NULL>	Patients diagnosed with lateral epicondylitis of the elbow; painful clinical presentation on the lateral aspect of the elbow and magnetic resonance imaging showing partial insertion tear of the extensors less than 50%; age over 18 years; both genders.	Patients with complete or partial tears greater than 50% of the extensor muscles or partial tears secondary to previous trauma or fracture; patients who have undergone previous surgery on the affected elbow or who have undergone previous elbow infiltration in the last 6 months; patients with other associated causes of painful elbow pathology such as osteoarthritis, loose bodies in the joint, joint stiffness; concomitant neck pain or other arm pain, symptoms suggestive of radicular neurological conditions; patients with active infections; pregnant women; and patients using immunosuppressants or chronic corticosteroid therapy.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-4mz6w9	Effect of Inspiratory and Expiratory Training on autonomic modulation, exercise capacity and pulmonary capacity of Chronic Obstructive Pulmonary Disease patients	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2210	"Influence of Respiratory Muscle Training on hemodynamic changes,
pulmonary and autonomic diseases in patients with COPD"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-4mz6w9	<NULL>	Volunteers with the diagnosis of Chronic Obstructive Pulmonary Disease; who had inspiratory muscle weakness (70% of predicted maximal inspiratory pressure); with absence of heart failure; with stable pharmacological treatment; and with no comorbidity such as type 2 diabetes mellitus and hypertension.	Volunteers who had acute myocardial infarction three months before inclusion in the study; unstable ventricular arrhythmia or in the last three months before onset; acute respiratory disease; rheumatic diseases; degenerative diseases; neurological sequelae and cognitive deficit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-5h6rzs	Effect of inspiratory muscle training on respiratory muscle	Recruiting	Intervention	2015-05-11	<NULL>	<NULL>	467	Effect of inspiratory muscle training on adaptation structural and neural of respiratory muscle	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Universidade Federal do Rio Grande do Norte	Rafaela Pedrosa	https://ensaiosclinicos.gov.br/rg/RBR-5h6rzs	<NULL>	Male and female; aged between 18 and 29 years; absence of visible deformities in the spine; absence of respiratory or neurological disease; absence of other significant pathology that could interfere in the recording of the electrical signal; BMI between 19 and 25 kg/m2; not show lesions at sites of electrode placement; FEV1/FVC&gt; 80% and FEV1&gt; 80% predicted; not being a smoker; not practice regular physical activity.	Inability to perform the protocol established by the study; present any problems during data collection; be unable to understand and/or perform procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-8h32gy	Effect of intensity of electric current and evidence of blinding method	Data analysis completed	Intervention	2015-08-17	<NULL>	<NULL>	590	Effect of intensity of interferential current and validation of the placebo method	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-15	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8h32gy	<NULL>	Healthy subjects; 18 to 60 years of age.	Participants with peripheral nerve injury in the upper limbs; presence of pain in the upper limbs; pregnancy; chronic diseases; use of cardiac pacemaker; epilepsy; allergy to the material of the electrodes; current use of analgesic medication or in the last seven days; altered skin conditions or loss of sensation in the established areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-6dk3y3	Effect of interferential current combined with exercise in patients with fibromyalgia: randomized clinical trial	Recruiting	Intervention	2016-12-27	<NULL>	<NULL>	1115	Effect of interferential current combined with exercise on fibromyalgia: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6dk3y3	<NULL>	Patients with fibromyalgia, diagnosed according to the criteria of the American College of Rheumatology, female, aged 18 to 60 years, without physical therapy concomitant.	Subjects will be excluded if they have concomitant rheumatologic disease, severe psychiatric disorders or any contraindication to prevent the use of interferential current, such as allergies to the electrodes, cardiac pacemaker, pregnancy, epilepsy, skin conditions or deficient skin sensation in the areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-10qzbjms	Effect of intervention with exercise, nutritional guidance, and therapy in severe obesity	Recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7308	Effects of physical exercise associated with a nutritional and psychological intervention on malignant obesity: relationship between cardiovascular risk and oxidative stress	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Escola Superior de Educação Física da Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10qzbjms	<NULL>	Volunteers eligible for bariatric surgery; both sexes; non-smokers; between 18 and 59 years old; body mass index greater than or equal to 35 kg/m² in the population with comorbidities; and body mass index greater than or equal to 40 kg/m² in the population without comorbidities	Super obese volunteers (body mass index greater than 50kg/m²); diagnosed with cardiac pathologies; who cannot exercise due to musculoskeletal health conditions; does not have internet access to follow interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-10wjzrt7	Effect of intervention with exercises and pain neuroscience education on physical, cognitive, and emotional function and gait parameters of elderly people with and without knee osteoarthritis: a randomized clinical trial	Not yet recruiting	Intervention	2025-12-22	<NULL>	<NULL>	8676	Effect of intervention with multicomponent exercises and pain neuroscience education on physical, cognitive, psychoemotional function and gait parameters of elderly individuals with and without Knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-31	Obras Socias e Educacionais de Luz	<NULL>	<NULL>	<NULL>	Age between 60 and 80 years; female and masculine gender; diagnosis of Medial Femorotibial Osteoarthritis confirmed by X-ray examination; grade 2 or 3 Knee Osteoarthritis according to the Kellgren and Lawrence criteria	Diagnosis of Osteoarthritis in the Hip and/or Ankle; grade 4 Osteoarthritis in one or both knees; body mass index less than 35 kg/m²; presence of Vestibulocochlear Diseases; uncontrolled Cardiac or Respiratory Arrhythmias; Convulsive Syndrome; Musculoskeletal Disorders with functional limitation, such as Diabetic Neuropathies and Cutaneous Ulcers of any etiology; use of Prostheses or Orthoses in the lower limbs; Fractures in the last six months; presence of Dementia; inability to Walk independently; being under Physical Therapy treatment concurrently with the intervention period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-468wm2	Effect of interventions on the quality of sleep and stress in people with Diabetes	Not yet recruiting	Intervention	2015-12-09	<NULL>	<NULL>	848	"Effect of non-pharmacological interventions on the quality of sleep and stress
emotional in people with Type 2 Diabetes Mellitus"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-468wm2	<NULL>	People with Type 2 Diabetes Mellitus in clinical follow-up in that service; aged greater than 18 years; both sexes; who have active telephone contact; not forming any pharmacological / non-pharmacological treatment for improving sleep quality or that interferes it.	People that are experiencing cognitive impairment , according to an evaluation of the Mini -Mental State Examination ( MMSE), according to the educational tracks; People who submit total score on the Pittsburgh Sleep Quality Index (PSQI less than or equal to 5, defining them as &quot;good sleepers&quot;); Night Workers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-8c2qyhj	Effect of intestinal imbalance on the defense cells of the body	Recruiting	Intervention	2022-03-24	<NULL>	<NULL>	5299	Investigation of the effect of Gut Dysbiosis on histone post-translational modifications in neutrophils	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Instituto de Biologia - Universidade Estadual de Campinas	Instituto de Biologia - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8c2qyhj	<NULL>	Male, volunteer subjects; age between 20 and 29 years; eutrophic (Body Mass Index between 18.5 and 29.9); non smokers; in good general health.	Recent (up to 60 days before treatment) history of: antibiotic or corticosteroid therapy; vaccination; continuous drug therapy. Diagnosis or clinical signs of: metabolic diseases; acute or chronic inflammatory diseases ; autoimmune diseases; allergy or atopy; cancer; digestive system diseases; acute or chronic infectious disease known to impair general health or immune responses (for examples: HIV infection, hepatitis C, influenza, acute herpes simplex); depression, hypochondria, or other psychiatric illnesses that may lead to risky behaviors. Not mentioned conditions that may interfere with the study will follow medical advice regarding exclusion or permanency in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-10242sbz	Effect of intraoral and extraoral Photobiomodulation Therapy in the treatment of oral mucosal diseases	Not yet recruiting	Intervention	2023-01-18	<NULL>	<NULL>	6930	Intraoral and extraoral Photobiomodulation Therapy in the treatment of common oral mucosal diseases: basket trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2023-07-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10242sbz	<NULL>	volunteers; diagnosed with oral lichen planus or burning mouth syndrome; treatment-naive; both genders; minimum age of 18 years	patients with oral lichen planus diagnosed with gastrointestinal ulcer; decompensated systemic arterial hypertension and/or decompensated diabetes mellitus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-7mmkzt7	Effect of Intraoral Mandibular Advancement Intraoral Appliance (OAm) therapy on Obstructive Sleep Apnea, systemic status,   periodontium of pregnant women and its influence on the fetus and newborn: clinical-laboratory analysis of medical and dental images	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8847	Effect of the Intraoral Mandibular Advancement Device (AIOam) and the Silicone Occlusal Splint (POs) in pregnant women with Obstructive Sleep Apnea and on fetal growth: clinical-laboratory and medical-dental imaging analyses	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Instituto de Ciências e Tecnologia da Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Chronic hypertensive pregnant women with OSA (Apnea-Hypopnea Index AHI &gt; 5 and &lt; 30 events/hour); chronic hypertensive pregnant women with 20 to 22 weeks of gestation; oxyhemoglobin desaturation index (ODI) ≥ 5 events/hour; chronic hypertensive pregnant women aged 20 to 35 years; chronic hypertensive pregnant women with healthy periodontium and absence of caries; nulliparous and multiparous chronic hypertensive pregnant women; sign the Free and Informed Consent Form	Women with pregnancy period &lt; 20 weeks and &gt; 22 weeks with apnea hypopnea index &gt;30/h; with dessaturation index &gt;30/h or with more than 10% of desaturation time &lt;90%; active periodontal disease; severe temporomandibular disorder; drink alcohol; smoke and use drugs; use anti-inflammatory drugs; hormonal therapy; psychiatric disorders; infectious diseases; hematological diseases; clinical history of using orthodontic appliances less than 6 months before the proposed study;  twin pregnancies; using antidepressants; using in vitro fertilization	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-9zjghmk	Effect of Intravascular Laser Irradiation of Blood (ILIB) Laser on muscle damage, funcitional capacity and biomarkers in atheletes	Recruitment completed	Intervention	2024-08-28	<NULL>	<NULL>	7285	Effect of ILIB laser on muscle damage, functional capacity and biomarkers in athletes	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-16	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9zjghmk	<NULL>	Both sexes; age between 16 and 30; sign the Free and Informed Consent Form (FICF) for athletes over 18 years of age; sign and Informed Consent Form (ICF) for athletes under 18 years of age	Functional (musculoskeletal) incapacity; be undergoing of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-8pbydg	Effect of irradiation with violet light on the clinical performance of dental bleaching of low concentration bleaching agents.	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	4446	Effect of irradiation with violet light on the clinical performance of dental office whitening performed with 6% hydrogen peroxide containing TIO2_N nanoparticles and their impact on quality of life - Randomized Clinical Study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade de Odontologia de Araraquara	Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-8pbydg	<NULL>	"Young adult patients from Araraquara and surrounding regions; over 18 years of age; of both genders; with good general health condition; who
Have teeth from 14 to 24 and from 34 to 44 healthy and aligned; without lesions of caries; hypoplasia of the enamel; staining by tetracycline or fluorosis &gt; TF2."	"Infants; Pregnant women; Smokers; Patients with parafunctional habits (bruxism and / or tightening); Gingival recession; Incisal wear; injuries
Of erosion; Abrasion or abfraction; Chronic analgesic / anti-inflammatory users and desensitizing toothpaste."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-9fjqvng	Effect of jabuticaba on vascular health and muscle recovery	Recruiting	Intervention	2023-02-15	<NULL>	<NULL>	7252	Effect of Jabuticaba Consumption on vascular health and muscle recovery in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-15	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9fjqvng	<NULL>	Healthy individuals; of both sexes; aged between 18 and 45 years; with at least three months of prior experience in resistance training will be invited to participate in this study	Cardiovascular, pulmonary, or metabolic diseases (e.g., asthma, diabetes, hypertension, dyslipidemia); urinary tract infection; smoking; pregnancy or breastfeeding; limb injuries; use of supplements (creatine, caffeine, antioxidant vitamins, minerals); anabolic steroids or anti-inflammatory drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-8wwq9t	Effect Of Jabuticaba Peel On Metabolism	Recruiting	Intervention	2019-10-29	<NULL>	<NULL>	5837	Effect Of Jabuticaba (Plinia Jaboticaba) Peel Supplementation On Metabolism	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Faculdade de Engenharia de Alimentos	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8wwq9t	<NULL>	men and women; ity between 18 and 60 years; diagnosed with metabolic syndrome, with ≥3 components Metabolic syndrome, or seja, altered jejum glycemia (≥ 100 mg/dL), hypertension (systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 85 mm Hg), central adiposity (circumference abdominal ≥ 88 cm for women and ≥ 102 cm for men), hypertriglyceridemia (≥ 150 mg/dL) and low levels of HDL cholesterol (&lt;40 mg/dL in women and &lt;50 mg/dL in men).	Taking oral hypoglycemic agents; with food allergy, hypersensitivity or intolerance; smokers; vegetarians or vegans; diabetes, individuals who have been taking vitamins, probiotics and dietary supplements for the past 3 months; women in pregnancy or breastfeeding; clinical or laboratory evidence of renal, hepatic, intestinal, cardiac or other serious systemic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-5d7tcjs	Effect of juçara fruit (Euterpe edulis Martius) intake in damage indicators caused by free radicals, fatigue, and performance in trained cyclists	Terminated	Intervention	2023-05-24	<NULL>	<NULL>	6153	Effect of juçara fruit (Euterpe edulis Martius) intake on oxidative stress biomarkers, fatigue, and performance in trained cyclists: a randomized, placebo-contolled, cross-over, and triple-blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-5d7tcjs	<NULL>	Male; aged between 19 and 45 years; with a history of sports practice for more than 6 months with cycling exercises of at least 6 hours per week or 200 km per week	Smoking; chronic diseases; metabolic disorders; physical disabilities; musculoskeletal injuries; reporting consumption of vitamin and mineral supplements, ergogenic resources (carnitine, arginine, creatine, caffeine, nitrate, beta-alanine, and sodium bicarbonate), use of steroids in the last six months; and use of medications in the previous week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-99z7jnq	Effect of Ketamine combined with conventional treatment in Treatment-Resistant Depression and Suicide Risk	Not yet recruiting	Intervention	2025-02-10	<NULL>	<NULL>	7730	Effectiveness of Ketamine as an adjuvant to Lithium Carbonate and standard pharmacological treatment in adults with treatment-resistant unipolar and bipolar depression and the risk of suicide with intent: a double-blind study	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2025-02-15	Hospital Universitário Walter Cantídio Universidade Federal do Ceará	Hospital Universitário Walter Cantídio Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-99z7jnq	<NULL>	Participants of either sex; aged between eighteen and sixty-five years; body weight of fifty kilograms to one hundred twenty kilograms; informed consent obtained prior to participation; effective contraceptive methods for sexually active heterosexual women of childbearing potential (blood or urine test requested during screening, on medication administration days, and in case of clinical doubt about pregnancy status during the observation period); clinical stability demonstrated by physical examination, medical history, vital signs, and twelve-lead electrocardiogram during screening; abnormalities allowed if deemed clinically insignificant by the principal investigator and documented in source records; agreement to receive standard pharmacological treatment for treatment-resistant depression, treatment-resistant bipolar depression, and/or suicidal risk, as assessed by the responsible physicians; treatment-resistant depression: current major depressive episode without psychotic features, confirmed by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version, Montgomery-Åsberg Depression Rating Scale score of eighteen or higher, resistance to two or more antidepressants and/or adjunctive agents; treatment-resistant bipolar depression: current major depressive episode without psychotic features, confirmed by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version, diagnosis of bipolar disorder type I or II according to DSM-5 criteria, absence of sustained symptomatic remission for at least eight weeks or intolerance to two different treatments; suicidal risk with Montgomery-Åsberg Depression Rating Scale score of twenty-eight or higher, current suicidal ideation with intention confirmed by the Columbia-Suicide Severity Rating Scale and Montgomery-Åsberg Depression Rating Scale item 10 score ≥ 4	Manic episode limited to groups with treatment-resistant depression or suicidal intent; major depressive episode with psychotic features; schizophrenia or schizoaffective disorder as determined by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version; alcohol or substance use disorder, excluding tobacco, or withdrawal symptoms requiring detoxification; inpatient or outpatient detoxification treatment within six months prior to screening; suicidal ideation or behavior primarily due to a condition other than major depressive disorder; current clinical diagnosis of autism spectrum disorder, neurocognitive disorders, or intellectual disability; history of seizures, except for childhood febrile seizures; malnutrition; inability to provide informed consent or comply with study requirements; pregnancy, lactation, or intention to become pregnant within the next twelve weeks; active infection with hepatitis B virus, hepatitis C virus, human immunodeficiency virus, or COVID-19; history of traumatic brain injury within the last six months; history of hypersensitivity to the study medications or their excipients; use of monoamine oxidase inhibitors within fourteen days before screening; cardiac disease or abnormal cardiac repolarization, including a history of myocardial infarction, angina pectoris, or coronary artery revascularization within six months prior to the start of the study treatment; history of clinically significant cardiac arrhythmias, complete left bundle branch block, advanced atrioventricular block, including bifascicular block, Mobitz type two, or third-degree atrioventricular block within six months prior to the start of the study treatment; Fridericia-corrected QT interval (electrocardiographic trace measured from the beginning of the QRS complex to the end of the T wave) at rest of greater than or equal to four hundred fifty milliseconds for men or greater than or equal to four hundred sixty milliseconds for women at screening or prior to the first dose on day one; inability to determine the Fridericia-corrected QT interval (electrocardiographic trace measured from the beginning of the QRS complex to the end of the T wave); risk factors for Torsades de Pointes, including uncorrected hypokalemia or hypomagnesemia, history of heart failure, or history of clinically significant or symptomatic bradycardia, long QT syndrome, family history of sudden unexplained death or congenital long QT syndrome; concomitant medication with a known risk of Torsades de Pointes that cannot be discontinued or replaced with a safe alternative medication seven days before screening and throughout the double-blind phase; average systolic blood pressure greater than one hundred forty millimeters of mercury or diastolic blood pressure greater than ninety millimeters of mercury at screening and before the first dose of medication on day one; elevated blood pressure or intracranial pressure that poses a serious risk, including vascular disease such as aneurysm and a history of intracerebral hemorrhage; any other condition, including liver disease or malignancy, that, according to the principal investigator&apos;s assessment, compromises the participant&apos;s safety; evidence of significant renal impairment indicated by an estimated glomerular filtration rate of less than forty milliliters per minute per one point seventy-three square meters at screening; use of other investigational medications within thirty days before screening; women of childbearing potential unless using highly effective contraceptive methods during the study treatment and for one week after discontinuation of the medication; effective contraceptive methods include total abstinence when consistent with the participant&apos;s preferred and usual lifestyle; bilateral oophorectomy with or without hysterectomy, total hysterectomy, or tubal ligation at least six weeks before administration of the investigational medication; male sterilization at least six months before screening; use of intrauterine device or intrauterine system; oral contraceptive or systemic hormonal contraception, including transdermal or implanted hormonal methods; women considered postmenopausal and not fertile if they have experienced twelve months of natural amenorrhea with a clinically appropriate profile, history of age-appropriate vasomotor symptoms, bilateral oophorectomy with or without hysterectomy, total hysterectomy, or tubal ligation for at least six weeks; absence of previous clinical exams or assessments that may confirm the absence of the aforementioned conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3wg7d8x	Effect of Kinesio Taping on edema, pain, and trismus in the postoperative period of Orthognathic Surgery: a randomized controlled clinical trial	Recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8886	Effect of Kinesio Taping on clinical parameters in the postoperative period of Orthognathic Surgery: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-08	Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Participants aged 18 years or older; of both sexes; with Class III dentofacial deformity; undergoing orthognathic surgery.	Presence of comorbidities or chronic use of medications with potential influence on postoperative edema; hypersensitivity to elastic therapeutic taping; failure to attend postoperative follow-up visits or withdrawal from the study; occurrence of postoperative infection, surgical wound dehiscence, or undesirable fractures during the intraoperative period.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-2xkfs3	Effect of labyrinth stimulation exercises associated with the repositioning technique in patients with benign paroxysmal positional vertigo	Recruitment completed	Intervention	2018-05-17	<NULL>	<NULL>	1810	Efficacy of vestibular rehabilitation in the treatment and spacing of seizures in patients with Benign Paroxysmal Positional Vertigo	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-10	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-2xkfs3	<NULL>	Age above 18 years; with diagnosis of Benign Paroxysmal Positional Vertigo; test of Dix-Hallpike or Roll test positive	Central vestibular disorders; Dix-Hallpike and Roll test negative; use of vestibular suppressive drugs; motor restraint; visual restriction; cognitive restriction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-5643qq3	Effect of Laser Acupuncture in children with Autism	Recruitment completed	Intervention	2026-04-13	<NULL>	<NULL>	9090	Effectiveness of Laser Acupuncture in children diagnosed with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Programa de Pós-Graduação em Odontologia da Universidade Federal do Paraná	<NULL>	<NULL>	<NULL>	Male and female children; aged between five and twelve years; previously diagnosed with Autism Spectrum Disorder (ASD) and evaluated by a neurologist; who regularly attend the multidisciplinary institution in which they are officially enrolled	Children with syndromic conditions, those with contraindications to laser acupuncture (such as undergoing cancer treatment; uncontrolled epilepsy; active infections; fever; wounds; or the presence of dermatitis at the acupuncture points); or those who refuse to participate in the study will be excluded from the main trial	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-73j768n	Effect of Laser and Blood Concentrates on Bone Repair in Maxillary Sinuses Grafted with Deproteinized Bovine Bone	Recruiting	Intervention	2023-10-17	<NULL>	<NULL>	6683	Effect of Photobiomodulation and Platelet-Rich Fibrin on bone repair in maxillary sinuses grafted with Deproteinized Bovine Bone	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-73j768n	<NULL>	The patient required to present between 18 and 60 years old, need unilateral or bilateral elevation of the floor of the maxillary sinus for subsequent installation of osseointegrated implants. present bone availability associated with the alveolar ridge adjacent to the maxillary sinus less than or equal to 3mm. present good systemic health. present at least less than 4 months of healing of the socket after tooth extraction	Smokers. decompensated diabetics. patients with chronic or aggressive periodontitis. patients who use drugs that alter bone metabolism. patients who have chronic infections of the upper airways. patients who chronically use anti-inflammatory drugs and antibiotics, people with bruxism, alcoholics, drug addicts. pregnant women or those who wish to become pregnant in the next year. history of radiotherapy treatment in the head and neck region, patients with pathologies that affect bone metabolism. patients who have had a large rupture of the membrane during surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-2p25mw5	Effect of laser application on oral mucosa inflammation in patients undergoing Chemotherapy	Terminated	Intervention	2025-10-21	<NULL>	<NULL>	8435	The prognostic and therapeutic effect of low-level Lasertherapy on Oral Mucositis in patients undergoing Chemotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-05	Hospital Nossa Senhora da Conceição	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-2p25mw5	<NULL>	Diagnosed with head and neck cancer (oral cavity, oropharynx and nasopharynx); both genders; chemotherapy for treatment of cancer; no painful symptoms; no diagnosis of oral mucositis	Patients who had already undergone chemotherapy treatment; any grade higher tan 0 in the Visual Analogic Scale (VAS) of painful symptoms; grade I, II, III or IV oral mucositis; using medications to control oral mucositis; patients who did not agree to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-2d3sf9	Effect of laser auriculotherapy on signs and symptoms of patients with problems in the chin joint.	Not yet recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3940	Effect of low-power laser auriculotherapy on signs and symptoms of patients with muscular temporomandibular disorder. A comparative study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-30	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2d3sf9	<NULL>	"Adult volunteers aged 18 years or over;
score equal to or greater than 3 in the
Triage Questionnaire of the American
Academy of Orofacial Pain; with the
presence of myofascial pain according to
the Research Diagnostic Criteria for
Temporomandibular Disorders (RDC /
TMD)."	"Volunteers with non-painful
temporomandibular disorder according to
RDC / TMD; patients with associated
diseases: fibromyalgia, facial paralysis,
rheumatoid arthritis, mental illness or
cognitive deficits that would impede the
understanding of some of the stages of the
research; pregnant women; with external
ear injuries or with immunodepression;
carriers of clotting disorders, metabolic,
vascular or neoplastic diseases; volunteers
submitted to other types of associated
therapies - interocclusal apparatus,
psychotherapy, physiotherapy, orthodontics,
alternative therapies; volunteers who use
continuous medication (analgesics, antiinflammatories,
muscle relaxants,
antidepressants / anxiolytics,
anticonvulsants)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-34zqrc	Effect of laser in the functional of temporomandibular joint	Recruitment completed	Intervention	2020-05-25	<NULL>	<NULL>	3874	Effect of low-level laser therapy in the functional of temporomandibular joint	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal do Piauí	Grupo de Pesquisa em Fisioterapia Avaliativa e Terapêuticas - GPFAT	https://ensaiosclinicos.gov.br/rg/RBR-34zqrc	<NULL>	young adults enrolled in the clinical sector of the physiotherapy school; age between 18 and 25 years; regardless of gender; agreed to participate in the study by signing the informed consent form.	individuals wearing a fixed or mobile orthodontic appliance; use of correction board; use of anti-inflammatory or muscle relaxants; with another pathogen that altered TMJ functionality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-63nvsq6	Effect of Laser Light alone or in conjunction with Antimicrobial Therapy in the treatment of Mouth Sores in patients with Oral and Oropharyngeal cancer	Terminated	Intervention	2022-02-18	<NULL>	<NULL>	6781	Evaluation of Photobiomodulation associated or not with Photodynamic Therapy in the treatment of Oral Mucositis in patients with Cancer of Mouth and Oropharynx - Double-Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal de Minas Gerais	Hospital do Câncer de Muriaé	https://ensaiosclinicos.gov.br/rg/RBR-63nvsq6	<NULL>	Patient underwent radiotherapy and chemotherapy with concomitant cisplatin; Patients underwent external radiotherapy with conventional fractionation (1.8 Grays day);  and received total dose of 60 Grays or more; Over 18 years old.	Patients with systemic diseases that impair wound healing (diabetes); Patients who cannot understand the research and the Free and Informed Consent Form; Patients with mouth opening difficulties prior to starting the proposed treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-8rwbb77	Effect of Laser Light associated with Corticosteroid irrigation in controlling inflammatory manifestations in lower third molar extractions - a randomized clinical trial	Not yet recruiting	Intervention	2024-09-15	<NULL>	<NULL>	7343	Effect of Photobiomodulation associated with Hydrocortisone irrigation for the control of inflammatory manifestations in the extraction of impacted lower third molars – a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-26	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8rwbb77	<NULL>	Eligibility criteria will include participants who: are between 18 and 40 years old, are not pregnant, require bilateral extraction of lower third molars with a similar degree of bone impaction, have no systemic diseases or local conditions that could interfere with the tissue repair process, undergo a surgical procedure lasting up to 60 minutes, have no contraindications to the use of hydrocortisone, have no history of hypersensitivity to mepivacaine, dipyrone, and ibuprofen, have the presence of upper and lower central incisors, and have no light hypersensitivity	Exclusion criteria will include participants under 18 or over 40 years of age, participants who are pregnant, procedures that exceed 60 minutes in duration, trans-surgical complications (e.g., hemorrhage or fainting), participants who do not follow up within the proposed interval or do not return for the second extraction, participants who report using medications other than those provided by the research team, use of anesthetics exceeding the amount outlined in this study (2 cartridges), as well as the absence of upper and lower central incisors, a history of hypersensitivity to mepivacaine, dipyrone, and ibuprofen, and light hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-9vv5rsw	Effect of laser on Diabetic Foot: randomized clinical trial	Recruiting	Intervention	2022-10-04	<NULL>	<NULL>	5646	Effectiveness of Laser therapy in Diabetic Foot: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-06	Faculdade de Enfermagem - Universidade Estadual de Campinas	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-9vv5rsw	<NULL>	Participants with diabetes mellitus; both genders; aged 18 or over; foot wound	Lupus; pyoderma gangrenosum; Steve Johnson Syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-8q8c6n	Effect of laser on individuals with tinnitus.	Data analysis completed	Intervention	2020-06-15	<NULL>	<NULL>	3922	The use of low-level laser in patients with tinnitus and without hearing loss	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-18	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-8q8c6n	<NULL>	Consent to the Informed Consent Form. Normal bilateral audiometry with ISO mean up to 25dB. Complaint of continuous tinnitus for at least six months. Age 18 years or older.	Performing another treatment for tinnitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-3t8pw38	Effect of Laser on maternal complications during the Postpartum period	Not yet recruiting	Intervention	2024-08-10	<NULL>	<NULL>	7204	Effect of Photobiomodulation therapy on complications maternal during the Postpartum	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal de Alfenas- Campus Santa Clara	Universidade Federal de Alfenas- Campus Santa Clara	https://ensaiosclinicos.gov.br/rg/RBR-3t8pw38	<NULL>	Age over 18 years; primiparous or multiparous; women after vaginal delivery with grade two, three, or four perineal laceration; women after vaginal delivery with episiotomy; approximation of the edges of the lesion by means of suturing (healing by first intention); pain graded in at least two, by the numerical scale of pain; ability to understand	Refusal to receive the protocol; presence of systemic or lesion-site infectious process; Birth of twins; hemodynamic instability; postpartum complications (hemorrhages); Use of medicines for associated diseases; Smoker; Diabetes mellitus or diabetes Gestational; neurological diseases; cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-8bwn97b	Effect of Laser on Pain and Movement in People with Problems in the Jaw Region	Recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8669	Effect of Photobiomodulation on Pain Intensity and Mobility in Individuals with Temporomandibular Dysfunctions	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-04	Universidade São Francisco	<NULL>	<NULL>	<NULL>	Age between 18 and 50 years; both genders; report pain greater than or equal to 4 on the Numerical Pain Scale (NPS greater than or equal to 4) in the temporomandibular joint region, not requiring clinical diagnosis, for a period equal to or greater than 3 months intermittently, that is, with intervals in which the pain ceases; pain/discomfort in the masseteric region and head and neck, associated with pain in the temporomandibular joint region, for a period equal to or greater than 3 months intermittently, that is, with intervals in which the pain ceases	Use any type of anti-inflammatory medication; use any type of orthodontic retainer plates	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-85s3r8	Effect of Laser on Perineal Pain realief after Vaginal Birth	Recruiting	Intervention	2019-09-24	<NULL>	<NULL>	3659	Effect of Low Intensity Laser on Perineal Pain relief after Vaginal Birth: triple blind randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de São Carlos - UFSCar	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-85s3r8	<NULL>	Women with a history of usual risk pregnancy; older than 18 years; literate; oriented; at most 24 hours postpartum; complaining of perineal pain after vaginal birth; absence of genitourinary pathology	Puerperal infection, hemorrhoids or varicose veins in the vulvar region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-5hgcgy4	Effect of Laser on Postoperative Pain and Quality of Life after Root Canal Treatment in patients with Apical Periodontitis	Recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6296	Effect of Photobiomodulation on Postoperative Pain and Quality of Life after Endodontic Treatment in patients with Apical Periodontitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-06	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5hgcgy4	<NULL>	Be over 18 years of age; both genders; having at least one tooth diagnosed with pulp necrosis and apical periodontitis, with no indication for surgical endodontic treatment; agree to participate in the research by signing the Free and Informed Consent Form (Annex 1)	Pregnant women; have severe health impairments that possibly have a negative impact on quality of life (neoplasms malignancies, severe heart disease, immunosuppression); be making continuous use of analgesic and/or anti-inflammatory drugs at the time of treatment endodontic; having hypersensitivity to non-steroidal anti-inflammatory drugs; present endodontic complications such as calcifications, resorption internal/external, dental perforations, longitudinal/vertical fractures, disease advanced periodontal or severe occlusal problems; have teeth with apical periodontitis in an element already endodontically treated (retreatments)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-9yrydw	Effect of laser on shoulder tendinitis	Recruiting	Intervention	2019-03-26	<NULL>	<NULL>	2547	Effects of photobiomodulation therapy on repair of rotator cuff tendinopathy of the shoulder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-03	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9yrydw	<NULL>	Rotator cuff lesion grades I and II in the Neer classification; both sexes; age from 18 to 70 years; have signed the informed consent form (TCLE); subacromial pain for at least three months; two of the three positive impact tests (Jobe, Hawkins and Neer).	History of shoulder dislocation and seizure test for positive displacement; intratendine calcifications of the rotator cuff; presence of a proximal humerus anterior fracture; previous surgery on the shoulder; clinical and imaging diagnosis of total rupture in the shoulder rotator cuff tendon; adhesive capsulitis of the shoulder; acronym type III classification of Bigliani on X-ray; use of corticosteroid infiltrations three months prior to the study; presence of rheumatic and neurological diseases; pregnancy; be performing some type of therapeutic intervention for the shoulder in some other service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-9nh9m4	Effect of laser on the pain of women with nipple damage	Recruitment completed	Intervention	2018-05-04	<NULL>	<NULL>	1758	An Influence of 2 joules of the Red Laser in the control of the Pain of puerperas with nipple Damage in breastfeeding: a double blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade Federal de São Paulo	Escola Paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-9nh9m4	<NULL>	Women; postpartum period; in the maternity hospital; with nipple damage; exclusively breastfed; with a single child born at term and weighing two thousand and five hundred grams or more.	Malformed nipples; mastitis; malignant disease; use of any topical substance in the nipple; photosensitivity or any adverse reactions to exposure to sunlight.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-5kwwxv	Effect of Laser therapy in dental trauma	Recruiting	Intervention	2019-06-24	<NULL>	<NULL>	2784	Effect of Photobiomodulation therapy in dental trauma of permanent anterior teeth,randomized blind and controlled clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-10-24	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5kwwxv	<NULL>	Patients with a history of dental trauma; extrusive luxation; intrusive; lateral;avulsion; in anterior permanent teeth, with a maximum age of 35 years.	Deciduous teeth; permanent posterior teeth and canines; enamel fracture; enamel fracture with or without pulp exposure; coronary-root fracture root fracture;concussion/subluxation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-62wx9b	Effect of laser therapy in patients with gums problems	Recruitment completed	Intervention	2019-10-09	<NULL>	<NULL>	4874	Effect of photodynamic therapy on clinical parameters, subgingival microbiota composition and salivary levels of IL-6, TNF-alpha, RANKL and OPG of patients with chronic periodontitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-17	Departamento de Odontologia - Universidade Federal do Rio Grande do Norte (UFRN)	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-62wx9b	<NULL>	Individuals with severe chronic periodontitis (localized or generalized, older than 18 years, presence of two sites in distinct sextants with depth at 5 to 9 mm probing and bleeding at probing.	Pregnant or breastfeeding patients; smoking; diabetics; allergic to phthalocyanine and methylene blue; undergoing periodontal treatment and / or antibiotics in the last 3 months; with systemic conditions that alter the periodontal tissue; dental elements with acute periodontal conditions (periodontal abscesses and gingivitis and / or necrotizing ulcerative periodontitis); with degree III mobility; with indicated extraction; anterior teeth and premolars with presence of endodontic lesion; cavities; extensive restorations; prosthesis or any occlusal dysfunction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-6w9v53s	Effect of Laser therapy in the prevention of post-procedure pain in patients with toothache	Terminated	Intervention	2023-06-30	<NULL>	<NULL>	6190	Effect of laser therapy on the prevention of postoperative pain in cases of endodontic urgency: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-08	Centro Educacional Universitário do Maranhão - CEUMA	Centro Educacional Universitário do Maranhão - CEUMA	https://ensaiosclinicos.gov.br/rg/RBR-6w9v53s	<NULL>	Patients aged between 18 and 50 years; both genders; with posterior teeth diagnosed with symptomatic irreversible pulpitis and coronary structure capable of receiving absolute isolation	Pregnant patients, patient with systemic disease that contraindicates endodontic treatment, including recent myocardial infarction, uncontrolled hypertension and uncontrolled diabetes; patient with ingestion of any type of analgesic / anti-inflammatory medication before treatment, patients with allergy to articaine, tooth with internal and external resorption, tooth with periodontal disease, lack of patient cooperation, patient with intolerance to non-inflammatory drugs steroids, teeth in orthodontic movement and teeth with anatomical changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-7t7gy3x	Effect of laser therapy in the treatment of inflammation around implants with or without the use of soft tissue grafts	Not yet recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8737	The effect of photobiomodulation in the treatment of patients with peri-implantitis, with or without the use of soft tissue grafts	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with at least one implant diagnosed with peri-implantitis; The implant must present: radiographic bone loss &gt; 2mm; probing depth &gt; 5mm; bleeding and/or suppuration on probing; prosthesis with at least 6 months of function; absence of implant mobility; age ≥18 years	Patients with previous peri-implant treatment at the surgical site; ASA III patients (except diabetics); Heavy smokers (&gt;20 cigarettes/day); Uncontrolled diabetic patients (HbA1c &gt; 7% or fasting glucose &gt; 180 mg/dL); Use of antibiotics in the last 30 days; Use of medications that alter the inflammatory response or bone metabolism; Pregnant and breastfeeding women; Patients with hemoglobinopathies; Patients with other systemic alterations that may compromise healing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-4gkp27w	Effect of laser therapy in the treatment of paresthesia in patients undergoing orthognathic surgery and wisdom tooth extraction	Recruitment completed	Intervention	2025-01-28	<NULL>	<NULL>	7690	Effect of photobiomodulation in the treatment of paresthesia in patients undergoing orthognathic surgery and third molar extraction: randomized, triple-Blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-09	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4gkp27w	<NULL>	Will be included, adults aged between 18 and 60 years; of both sexes and regardless of color or social class; with a main complaint of inferior alveolar nerve paresthesia who underwent orthognathic surgery or third molar extraction; who seek or are referred to &quot;Laboratório Especial de Laser em Odontologia da Universidade de São Paulo&quot; for the treatment of paresthesia; to all participants will be asked to sign the free and informed consent form	Participants with paresthesia unrelated to orthognathic surgery or third molar extraction will be excluded; patients who also present lingual nerve paresthesia; patients with sensory changes reported before surgery or with a history of injury to trigeminal nervous tissue due to other interventions; patients who present paresthesia of the maxillary and/or mandibular branches of the trigeminal nerve and are undergoing some other type of treatment for paresthesia (Acupuncture; systemic medication; local physiotherapy; electrical stimulation); be using antidepressant or anxiolytic medications, and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-35tnj7	Effect of laser therapy on clinical and subjective aspects in implant placement: A randomized clinical trial	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1844	Influence of low level laser therapy on clinical and subjective aspects in dental implant placement: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-08	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-35tnj7	<NULL>	To be included in the sample the patients should need for extraction of any teeth due to root crack/fracture or perforation with indication of immediate implant installation; good general health, which allow the tooth extracion and implant installation procedures; time availability to attend the follow-up appointments.	Patients presenting poor general health that prevents the accomplishment of the surgery for installation of dental implant; and patients who do not have available hours to attend for dental treatment and follow-up appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-94bckz	Effect of laser therapy on clinical aspects and post-operative pain after third molar extraction	Recruiting	Intervention	2020-01-10	<NULL>	<NULL>	3350	Influence of low-level laser therapy on clinical and subjective aspects after third molar extraction: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-18	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-94bckz	<NULL>	"To be included in the sample, patients will need to have the following characteristics:
Display the indication for third molar extraction;
Have a good general state of health that allows dental implant surgery;
Have time and time available to attend dental appointments"	Patients with any of the following characteristics may not be part of the sample: Patient with any systemic disease that prevents oral surgery; Patients who do not have time available for care.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-9fbrcsy	Effect of laser therapy on healing and pain reduction after surgery for correction of gummy smile	Recruitment completed	Intervention	2024-07-29	<NULL>	<NULL>	7164	The efficacy of Low-level Laser Photobiomodulation in tissue healing and postoperative pain following Clinical Crown Lengthening surgery in esthetic areas: a split-mouth, triple-blind, randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-09	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	https://ensaiosclinicos.gov.br/rg/RBR-9fbrcsy	<NULL>	Individuals over 18 years old; gummy smile caused by altered passive eruption or by improper positioning of gingival zeniths in the anterior region of the maxilla or mandible; having at least six teeth affected by the gummy smile; probing bleeding index less than 10%	Individuals with indications for gingivectomy/plasty; etiologies of gingival alterations indicating this type of surgery; patients with drug-induced gingival enlargement; patients with aesthetic restorations; orthodontic appliance users; those presenting active periodontal disease; smokers; pregnant or lactating women; individuals allergic to the medications prescribed in the study; patients with systemic diseases that may interfere with healing or periodontal health (such as diabetes, blood dyscrasias, among others)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-9cqvm3t	Effect of Laser Therapy on lower limb pain in people with Diabetes: a randomized clinical trial.	Not yet recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8782	Effect of Photobiomodulation on neuropathic pain in people with Diabetes: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-06	Faculdade de Enfermagem - Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18-65 years; diagnosis of diabetic peripheral neuropathy; ability to walk independently without equipment or devices.	Amputation of any part of the foot; ankle-brachial index &lt; 0.9.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-10w4cvsv	Effect of Laser Therapy on pain and functionality of women after cesarean section	Recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8798	Effect of Photobiomodulation on pain and functionality of women after cesarean section a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-31	Faculdade de Ciências da Saúde do Trairi	<NULL>	<NULL>	<NULL>	Women who have undergone a cesarean section; aged between 18 and 40 years; in the first 12 hours after delivery of a single fetus; with or without a history of diabetes; and systemic arterial hypertension of previous origin or acquired during the gestational period; who agree to participate in the research, agreeing to sign the Free and Informed Consent Form (FICF)	Women who do not complete all assessments; those who present any complication such as hemorrhage; post-cesarean wound dehiscence; or sepsis; women with ineffective communication during the research period that compromises understanding and responses to assessments; presence of cancer or suspicion of cancer; skin hypersensitivity; use of photosensitizing medications, in case of epilepsy; and changes in sensitivity	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-4msv7mh	Effect of Laser therapy on pain in lactating postpartum women with nipple Fissures	Not yet recruiting	Intervention	2025-07-31	<NULL>	<NULL>	8173	Effectiveness of a protocol using Photobiomodulation therapy on pain in lactating postpartum women with nipple Fissures: a randomized, controlled, double-blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Alfenas UNIFAL-MG	Universidade Federal de Alfenas UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-4msv7mh	<NULL>	Postpartum women over 18 years of age; with nipple fissure secondary to breastfeeding; with pain graded at least two by the NDT; with the ability to understand and answer questions	Women who refused to undergo the intervention; those using other substances on the nipple, such as ointments; presence of a systemic or local infectious process; presence of underlying diseases that make therapy difficult or impossible, such as diabetes mellitus; cancer; neurological diseases; cognitive alterations; pregnancy and photosensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-4mhhqzk	Effect of laser therapy on the physical capacity of patients with type 2 diabetes	Suspended	Intervention	2022-09-12	<NULL>	<NULL>	5601	Acute effect of Low Power Laser (red and infrared) on the performance of patients with peripheral arterial disease in the walk test: a randomized, double-blind, placebo-controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-10	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4mhhqzk	<NULL>	Diagnosis of Type 2 Diabetes Mellitus under treatment (presentation of a medical prescription containing the prescription of oral hypoglycemic agent and/or insulin); Both sexes; Between 45 and 75 years of age; Residence in the same city of the research	"Physical limitation (orthopedic, neurological or ophthalmic) to perform the physical tests (pain above 5 on the visual scale, disability or noticeable change in gait, amaurosis); Peripheral neuropathy from another cause (Hansen&apos;s disease, alcoholism or other); Symptomatic peripheral arterial disease (ankle-brachial index &lt; 0.9 with interruption of any physical test due to claudicating pain); Painful ulcer anywhere on the lower limbs at the time of the first evaluation or during any stage of participation in the project; Amputation above the transmetatarsal; active plantar ulcer or use of implantable electrical device (contraindications for Bioimpedance); BMI ≥ 40 kg/m2;
Hospitalization in the 2 months prior to the start of the research, for any reason; COVID-19 diagnosed by examination: in the last 3 months (without hospitalization); within the last 6 months (with hospitalization without intubation) or any period prior to the survey (if intubated) or having post-COVID symptoms (regardless of the period of infection); Supervised physical exercise or treatment with electrical stimulation or phototherapy applied to the muscles of the lower limbs in the 6 months before the start of the research; Two absences from application sessions (consecutive or interspersed) while participating in the project."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-2bxfbk8	Effect of Laser Therapy to Reduce Pain and Scarring in Postpartum Women	Recruiting	Intervention	2023-09-05	<NULL>	<NULL>	6806	Acute Effect of Low-Intensity Laser Therapy for Pain Reduction and Healing of Fissured Nipples in Postpartum Women: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2bxfbk8	<NULL>	Women; age from 18 years until 41 years; primiparous or multiparous; postpartum women up to 15 days postpartum; with some degree of nipple injury resulting from breastfeeding; babies born weighing at least 2500g; single pregnancy; in exclusive breastfeeding; no history of interventions with laser therapy in the previous 15 days; able to speak and understand the Portuguese language; who show interest in the project; be able to attend the Women&apos;s Health Research Laboratory (LAPESM); who can receive calls and messages via Whatsapp within 48 hours of the intervention; who sign the Free and Informed Consent Form (TCLE);	Women with inverted or pseudo-inverted nipples; who have mastitis during the intervention period; to start using antibiotic anti-inflammatory analgesics or any topical substance on the nipple (except breast milk); with photosensitivity or any adverse reaction to exposure to sunlight;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-82fp2rx	Effect of laser treatment on the major salivary glands of patients with Hypertension and Diabetes who have dry mouth and low saliva production and its impact on quality of life	Not yet recruiting	Intervention	2025-09-02	<NULL>	<NULL>	8250	Effect of Photobiomodulation on major salivary glands of Hypertensive and Diabetic patients with Hyposalivation and Xerostomia and its impact on quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-10	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-82fp2rx	<NULL>	Patients over 18 years of age; hypertensive patients taking antihypertensive medications; type 2 diabetics will be included	Patients undergoing cancer treatment; patients with Sjögren&apos;s Syndrome; those with renal failure; type 1 diabetics;pregnant women; breastfeeding women; patients using anxiolytics which have xerostomia and hyposalivation as a side effect; those who present any type of photosensitivity will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-7n55nz	Effect of Lasertherapy in Patients with High Blood Pressure	Not yet recruiting	Intervention	2019-02-27	<NULL>	<NULL>	2493	Effect of Irradiation with Intravascular Laser on Hemodynamic Variables of Hypertensives Patients: Study Protocol for Blinded Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-30	Associação Educacional Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-7n55nz	<NULL>	Hypertensive individuals with ages between 30 and 80 years; with a diagnosis of systemic arterial hypertension declared by medical certificate stages I or II and evidenced in ambulatory blood pressure monitoring; with drug therapy of at least 4 weeks.	Patients with hypotension prior to the application of laser; pregnant women; with glaucoma diagnosis;  using electronic implants - such as a cardiac pacemaker; with epilepsy; seizures;  history of neoplasias; photosensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-102g28dh	Effect of Lavander essential oil on Pain control, Anxiety and Surgical Discomfort in pacients submitted to third molar extraction (wisdom teeth)	Recruiting	Intervention	2023-07-26	<NULL>	<NULL>	8212	Effect of Lavander essential oil on Pain control, Anxiety and Surgical Discomfort in pacients submitted to third molar extraction. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-30	Universidade Federal do Paraná - UFPR	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-102g28dh	<NULL>	This study may include adults over 18 years of age of both sexes who require third molar extraction	Patients under 18 years of age, with a history of using pain or anxiety medications in the 15 days prior to the study, with a history of hypersensitivity to medications, substances or materials used in this experiment, pregnant or lactating women. Patients with general health problems will not be eligible for participation in the study, as well as immunosuppressed patients, people who use anticoagulant or antiplatelet therapy, HIV patients, diabetes mellitus, and patients who are undergoing chemotherapy, as these conditions may interfere with the study results.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-1085kmg5	Effect of Lavander on preoperative Anxiety and postoperative Pain: randomized clinical trial	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7186	Effect of Lavandula Angustifolia on preoperative Anxiety and postoperative Pain: randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-05-06	Hospital Universitário Onofre Lopes da Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-1085kmg5	<NULL>	Individuals of both genders; aged 18 and over; who will undergo elective surgical procedures in the field of otolaryngology	Presence of reported or confirmed dementia; patients on mechanical ventilation; tracheostomized patients; and previous skull base surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-6rr5yq3	Effect of Lavandula angustifolia Essential Oil on the management of Facial Myalgia, Anxiety, and Bruxism	Not yet recruiting	Intervention	2025-07-02	<NULL>	<NULL>	8097	Efficacy of Lavandula angustifolia Essential Oil in reducing signs and symptoms of Myofascial Pain, Bruxism, and Anxiety in children and adolescents: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-20	Programa de Pós-Graduação em Odontologia da Universidade Federal do Paraná	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-6rr5yq3	<NULL>	Participants of both sexes, regardless of race or ethnicity, aged between 5 and 17 years; with a diagnosis of myalgia or myofascial pain according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); and who present with related bruxism and anxiety	Participants who present with any cognitive impairment that prevents them from completing the questionnaires; whose guardians violate the study protocol, who demonstrate poor adherence to the treatment; or who provide information considered questionable by the investigators; children and adolescents with autoimmune diseases or syndromic conditions; those undergoing orthodontic treatment or those experiencing odontogenic pain; individuals using analgesic and/or anti-inflammatory medications within 48 hours prior to the start of the clinical assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9pc7fb	Effect of lavender essential oil on smokers with cigarette craving	Recruitment completed	Intervention	2018-01-18	<NULL>	<NULL>	1582	Evaluation of craving reduction in smokers with withdrawal syndrome under the effect of lavender essential oil	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Centro de Saúde Dr. Francisco Pinto de Oliveira	Centro de Saúde Dr. Francisco Pinto de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-9pc7fb	<NULL>	Volunteers in the smoking treatment group of the Basic Units of Family Health of the city of Campina Grande; Male and female; Over 18 years old.	Volunteers who use drugs/substances depressants of the central nervous system; diagnosis of psychiatric conditions or hypotension; hemophiliacs or who use anticoagulant substances; Do not have problems in the upper airways; which are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-56f4w8	Effect of Led Therapy (630 ± 20nm) in Herpes Simplex Labial	Recruitment completed	Intervention	2020-02-20	<NULL>	<NULL>	3517	Effect of Led Therapy (630 ± 20nm) in Herpes Simplex Labial- Randomized Double-Blind Controlled Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-11	Universidade do Vale do Paraiba UNIVAP	Universidade do Vale do Paraiba UNIVAP	https://ensaiosclinicos.gov.br/rg/RBR-56f4w8	<NULL>	age between 18 and 59 years old, Caucasian, first manifestation of the disease, history of cold sores and / or presented the lesion, healthy individual without comorbidities, agree and sign the Informed Consent Form, after clarifying the research.	presence of neoplastic lesions in the oral environment; HSV-2 lesion in the genitalia; belonging to the Fitzpatrick V and VI classification scale; pregnant or lactating women; hypersensitivity to any component in the acyclovir formula; liver or kidney problems against acyclovir indication ; intraoral herpes; For ethical reasons excluded volunteers received conventional treatment guidance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-9wz5fc	Effect of Lifestyle Modification on the Risk Factors for Heart Disease	recruiting	Intervention	2013-01-04	<NULL>	<NULL>	165	Effect of Different Lifestyle Interventions on Metabolic Syndrome: Physical, Metabolic and Behavioral Aspects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-10	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9wz5fc	<NULL>	Men and women between 30 and 59 years of age with an abdominal circumference higher than 88 cm for women and higher than 102 cm for men and two (02) or more of the following findings:Blood pressure: systolic equal or higher than 130 mmHg and diastolic equal or higher than 85 mmHg; fasting glucose: equal or higher than  100 mg/dl; triglycerides:equal or higher than  150 mg/dl; HDL cholesterol less than 40 mg/dl for men and less than50 mg/dl for women.	Absolute contraindication to physical activity for musculoskeletal problems, neurological, vascular events (intermittent claudication), lung and heart; Presence of a diagnosis of severe psychiatric disorders and / or presence of significant cognitive impairment assessed by the team through the Mini-Mental State Examination; Difficult to contact and inability to return and follow-up, not available to participate in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-6yggjzm	Effect of light intensity on body responses during and after maximal progressive exercise.	Recruitment completed	Intervention	2026-05-06	<NULL>	<NULL>	9168	Effect of light intensity on cardiovascular and metabolic responses during and after maximal progressive exercise	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-02	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Men aged 20 to 40 years; normotensive; physically active; non-smokers; with a body mass index less than or equal to 30; without diseases; and not using medications; vitamins; or supplements on a regular basis.	Physically inactive or highly active individuals; hypertensive individuals; obese individuals; those with regular use of medications and those with any disease.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-3jjkk57	Effect of Light on Skin Inflammation: Follow-up Study	Recruitment completed	Observational	2026-03-30	<NULL>	<NULL>	9029	Evaluation of the Effect of Photobiomodulation in Hidradenitis Suppurativa: A Prospective Study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Hospital de Clínicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Participants diagnosed with hidradenitis suppurativa who present with active lesions; individuals over eighteen years of age; patients capable of participating in the study autonomously and without cognitive impairment.	Participants with skin lesions or inflammatory conditions that have not yet been formally diagnosed as hidradenitis suppurativa by a medical professional; individuals who missed more than two consecutive treatment sessions during the four-week intervention period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-6vf3mgg	Effect of light physical exercise with mild Restriction of blood flow on the muscle strength of the arms in the elderly	Not yet recruiting	Intervention	2021-10-04	<NULL>	<NULL>	4939	Effect of low intensity resistance training with partial blood flow Restriction on upper limb muscle strength in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Estadual de Ciências da Saúde de Alagoas	Universidade Estadual de Ciências da Saúde de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-6vf3mgg	<NULL>	Seniors; both sexes; Ages between 60 and 79 years	Functional disability; moderate to severe cognitive deficit; medical restriction to physical exercise; strength training for more than 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-5bv8rd	Effect of light therapy (laser) in patients with respiratory disease	Recruiting	Intervention	2017-05-22	<NULL>	<NULL>	1242	Acute effects of photobiomodulation on respiratory variables and functional capacity in individuals with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-30	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5bv8rd	<NULL>	Volunteers over 18 years of age; diagnosis of COPD with moderate to severe classification; clinically stable; who present symptoms of dyspnea due to small and medium effort.	Alcoholics; volunteers with cardiac pacemaker implantation; neurological disease; acute exacerbations of the disease requiring hospital admission or systemic corticosteroids in the 4 weeks prior to the study; regular exercise (more than 3 times a week) in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7rmtzg	Effect of lipids associated with toothbrushing regarding teeth color alteration, surface roughness and microhardness - an in vitro and in situ study.	Data analysis completed	Intervention	2019-01-16	<NULL>	<NULL>	3984	Effect of phytosphingosine associated with toothbrushing regarding color alteration, surface roughness and microhardness of dental enamel - an in vitro and in situ study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7rmtzg	<NULL>	Both genders; overall health status; with no oral pathologies; age between 20 and 35 years.	Use of removable prosthesis; use of orthodontic device;fluoride compounds use in the last two months; pregnant women; breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-93996y	Effect of liquid and bar soap in healthy term newborns	Recruitment completed	Intervention	2018-07-13	<NULL>	<NULL>	4014	Effect of liquid and bar soap on skin in healthy term newborn: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-15	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-93996y	<NULL>	Newborns with gestational age at birth between 37 to 42 weeks and six days; from the Obstetric Center; with spontaneous breathing; with absence of congenital anomalies such as anencephaly, myelomeningocele, gastrocystic, spina bifida and dermatological diseases such as epidermolysis Bullosa impetigo neonatal ichthyosis, neonatal omphalitis	Newborns with neuropathies or diagnosed heart diseases after inclusion; transferred from the joint room to neonatal unit or intensive care unit after inclusion, exhibiting hypothermia (less than 36.5°C) or hyperthermia (greater than 38°C); in treatment with phototherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-27sysfx	Effect of local application of Chalcone T4 associated with conventional treatment of Periodontitis: Randomized clinical study	Recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7758	Effect of local application of Chalcone T4 in the adjunctive treatment of Periodontitis: Randomized clinical study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-07-01	Faculdade de Odontologia da Universidade Estadual Paulista Julio de Mesquita Filho Campus Araraquara	Centro Universitário Central Paulista	https://ensaiosclinicos.gov.br/rg/RBR-27sysfx	<NULL>	Healthy volunteers; both genders; over 18 years old; non-smokers; with the presence of stage III grade A periodontitis, in at least two sites in two different quadrants; with a probing depth greater than or equal to five millimeters; active periodontal disease, verified by the presence of bleeding on probing; have at least fifteen remaining teeth	Volunteers with systemic diseases that contraindicate periodontal treatment, which require antibiotic prophylaxis or use of medications that interfere with the evolution of periodontal disease and/or the results of treatment; pregnant or lactating women; volunteers who smoke or who stopped the habit less than 5 years ago; having used antimicrobials in the last three months; having used steroid or non-steroidal anti-inflammatory medications continuously for more than 7 days in the last 3 months; having received periodontal treatment in the last year; have fewer than 15 teeth present	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-103bvzkh	Effect of local ice before anesthesia for vulva biopsies on the comfort of outpatients	Recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7563	Effect of local cooling prior to anesthesia for vulva biopsies on the comfort of outpatients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Hospital da Mulher Prof. Dr. J. A. Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-103bvzkh	<NULL>	Women over 18; women in the process of diagnosis and treatment of Lower Genital Tract Pathologies; women with preserved motor skills (nerve and muscular functions) of the lower limbs; women with preserved local sensitivity	Previous motor deficiency in lower limbs; non-communicating patient; patients with cold urticaria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-87qh649	Effect of Long-Term Dietary Nitrate Intake on health parameters in individuals undergoing Physical Activity	Recruiting	Intervention	2023-03-27	<NULL>	<NULL>	7200	Effect of Chronic Ingestion of a Nitrate-Rich Diet on muscle performance, vascular health and microbiota composition in different populations undergoing a Training Program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-87qh649	<NULL>	Adults aged between 18-45; both sexes; physically active. Apparently healthy elderly people (over 60 years old); both sexes; eutrophic; physically active. unhealthy elderly (over 60 years old); both sexes; overweight; physically active; with the presence of one or more of the following clinical conditions: high triglycerides; high-density lipoprotein reduced cholesterol; increased waist circumference; high fasting blood sugar	Adults with cardiovascular diseases; inflammatory bowel diseases; lung disease; diabetes mellitus; hypertension; dyslipidemia; smoking; urinary infection; pregnant women; lactating women; using drugs that interfere with amino acid metabolism or nitric oxide production; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; the presence of osteomioarticular lesions in 3 months; use of nutritional ergogenics; use of mouthwash. Apparently healthy elderly people without a diagnosis of cardiovascular disease, inflammatory bowel disease, lung disease, diabetes mellitus, hypertension, dyslipidemia and urinary tract infection; smoking; pregnant women, lactating women; using drugs that interfere with amino acid metabolism or NO production; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; use of nutritional ergogenics; use of mouthwash; the presence of osteomioarticular lesions in 3 months. Unhealthy elderly people with any other pathology not previously described; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; use of nutritional ergogenics; use of mouthwash; the presence of osteomioarticular lesions in 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-446wxd6	Effect of lotion with grape seed oil at 5% to reduce adverse reactions caused by radiotherapy: randomized clinical trial	Recruiting	Intervention	2022-10-20	<NULL>	<NULL>	5672	Effectiveness of 5% grape seed oil lotion for radiodermatitis reduction: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Cintia da Silva Marconato	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-446wxd6	<NULL>	Female; aged 18 or over; breast cancer; indication of adjuvant or exclusive radiotherapy; with intact skin in the treatment area.	Palliative radiotherapy; history of irradiation in the same treatment field; bolus use; bilateral irradiation; allergy to lotion with grape seed oil at 5% or the non-ionic base Crodabase CR2; Uncontrolled Diabetes Mellitus; connective tissue diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-7gvnk63	Effect of Low and Medium Frequency Currents on voice, pain and electrical activity of the cervical muscles	Recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5318	Effect of the Application of Low and Medium Frequency Currents on vocal quality, pain and electrical activity of the cervical muscles	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-28	Universidade Estadual Paulista - Faculdade de Filosofia e Ciências -  Campus de Marília	Universidade Estadual Paulista - Faculdade de Filosofia e Ciências -  Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-7gvnk63	<NULL>	women; between 18 and 31 years; with a history of frequent neck pain	smokers; daily alcohol users; history of cognitive or neurological problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-10y3cypd	Effect of low level intensity laser therapy with double wavelength and fibrin-rich plasma on the healing of third molar post-extraction sockets. A split-mouth randomized controlled clinical trial.	Recruitment completed	Intervention	2021-03-05	<NULL>	<NULL>	4816	Effect of low level intensity laser therapy with double wavelength and fibrin-rich plasma on the healing of third molar post-extraction sockets. A split-mouth randomized controlled clinical trial.	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2021-01-02	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10y3cypd	<NULL>	Patients older than 18 years of age; presence of good oral hygiene (plaque index &lt;20%); presence of the four third molars; and indication for dental extraction of all third molars	Patients with periodontal disease; patients with systemic diseases or conditions or who use drugs that alter bone metabolism; decompensated diabetics; pregnant or lactating women, heavy smokers; presence of metallic artifacts that hinder tomographic analysis; presence of periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-3xtxhtz	Effect of Low Pressure Fitness (LPF) on abdominal diastasis in postpartum women	Not yet recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6682	Effect of the Low Pressure Fitness (LPF) technique on rectus abdominis diastasis in postpartum women: blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Faculdade de Ciências da Saúde do Trairi	Faculdade de Ciências da Saúde do Trairi	https://ensaiosclinicos.gov.br/rg/RBR-3xtxhtz	<NULL>	Primiparous or multiparous women aged 18 or over; from 12 weeks after birth, BMI less than or equal to 29 kg/m27; who gave birth vaginally to a single fetus after a full-term pregnancy; parity &lt;4; with a separation of the rectus abdominis muscles &gt;2 cm and ≥2 fingers wide, above, below or at the level of the navel; with the ability to adequately contract the Pelvic Floor Muscles and perform the hypopressive maneuver of the LPF® Method adequately; who do not have: history of previous cesarean section; perineal laceration; medical restriction that prevents participation in the proposed assessments and interventions (cardiorespiratory, respiratory (including excessive coughing or sneezing), neurological and/or musculoskeletal changes); any form of vulvovaginal pain, low back pain, pelvic pain, prolapse or incontinence; a pathology of the lower limb (e.g. fracture, surgery, neoplasm); history of pelvic or abdominal surgery; or with a history of smoking; history of multiple pregnancies; complications related to the last pregnancy, such as Polyhydramnios, fetal macrosomia, diabetes or hypertension	Postpartum women who are unable to understand and/or complete the study questionnaires; who have decompensated reflux and those who miss 3 consecutive sessions of the intervention protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-5xpmkwf	Effect of Low-Intensity Laser with Red and Infrared lLight on healing of Gingival Recessions treated with different types of Soft Tissue Graft	Recruitment completed	Intervention	2022-11-14	<NULL>	<NULL>	6710	Effect of Dual-Wavelength Photobiomodulation on tissue healing after Root Coverage associated with different Soft Tissue Substitutes. A clinical, controlled randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5xpmkwf	<NULL>	Present bilateral single or multiple gingival recessions classified as RT1 (Miller class I and II) that require surgical treatment; lack of previous experience with surgical treatment for the treatment of gingival recessions; ability to maintain good oral hygiene, be systemically healthy or who have compensated systemic diseases; be legally responsible for their own acts, be between 18 and 60 years of age	History of untreated periodontal disease; smoking patients; furcation lesion in the tooth to be treated; presence of severe crowding, rotation or malposition of the tooth to be treated; hypersensitivity to any anesthetic; medication or antiseptic product used in surgery; medical limitation for elective surgical procedures; patients undergoing orthodontic treatment, and pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-9r2c367	Effect of Low-Intensity Strength Training with blood flow restriction on strength and muscle mass gains	Recruitment completed	Intervention	2025-12-26	<NULL>	<NULL>	8684	Effect of Low-Intensity Strength Training with blood flow restriction on the myofibrillar and extracellular areas of the muscle fiber	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-29	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	<NULL>	<NULL>	<NULL>	Not having performed strength training - ST in the six months prior to the start of the intervention; presenting adequate physical conditions for the practice of exercise; not having musculoskeletal injuries in the lower limbs or neuromuscular disorders that could compromise the execution of the proposed protocols; both sexes; ages between 18 and 35 years	Cardiac symptoms; diabetes; arrhythmias.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-7s6ymc	Effect of low-level laser and exercise improving balance and functionality in people with knee osteoarthritis	Not yet recruiting	Intervention	2015-07-28	<NULL>	<NULL>	563	Effect of Low-level Laser Therapy associated or not to exercise in subjects with knee osteoarthritis: randomized study on the impact of physical therapy clinical trial on postural control and functionality	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7s6ymc	<NULL>	Individuals of both genders, with ages between 40 and 70 years, with or without knee osteoarthritis.	Cardiovascular disease; neurological or musculoskeletal that disables the volunteer to perform exercises; evidence of secondary disease, inflammatory or metabolic; osteonecrosis and previous intra-articular injection; surgery in the previous three months to inclusion in the study or use of drug treatment that could potentially have an effect on the results of study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-9sgdsm2	Effect of low-power light on perineal injury after vaginal childbirth: a randomized, controlled, blinded clinical trial	Recruiting	Intervention	2026-02-25	<NULL>	<NULL>	8905	Efficacy of photobiomodulation in postpartum vaginal perineal trauma: a randomized, controlled, and blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Faculdade de Ciências da Saúde do Trairí	<NULL>	<NULL>	<NULL>	Age greater than 15 years; pain score greater than or equal to 3 on the Numerical Pain Rating Scale; presence of first degree and or second degree perineal trauma and or vulvar edema; immediate postpartum period up to 12 hours	Presence of vaginal wounds; Signs or examination that proves vaginal infection; Vulvar hematoma; Use of anti inflammatory drugs;Difficulty in understanding that makes it impossible to continue the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-7nz822g	Effect of macadamia nuts and peanuts on the metabolism of women with obesity	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8560	Consumption of macadamia nut (Macadamia integrifolia) and peanut (Arachis hypogaea L.) and their effects on the metabolism of women with Obesity: a crossover clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-12-12	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Women aged between 18 and 45 years; Women with a body mass index between 30.0 kg/m² (kilograms per square meter) and 39.9 kg/m² (kilograms per square meter), classified as having grade 1 and grade 2 obesity	Use of medications for the treatment of hyperlipidemia; with a diagnosis of hypertension, type 2 diabetes, dyslipidemia, and metabolic syndrome (self-reported); presence of diseases and/or history of surgeries that compromise nutrient absorption (self-reported); use of vitamin and/or mineral supplements; use of supplements containing fatty acids; use of supplements containing any amino acids; being pregnant and/or participating in another clinical study; undergoing diet therapy for weight loss; being a smoker and/or consuming alcohol; having a food allergy to nuts or peanuts; regular consumption of nuts or peanuts in the diet (in the last 3 months); intense physical activity	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:20
RBR-59j57vj	Effect of Magnesium Chloride supplementation on Depression	Data analysis completed	Intervention	2024-12-04	<NULL>	<NULL>	7567	Effect of magnesium chloride supplementation on brain electrical activity in individuals with depression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-59j57vj	<NULL>	Volunteers diagnosed with depression, both sexes, between 18 and 60 years old, both sexes, with stable use of antidepressants and no change in the treatment plan in the last 2 months, with weight within the limit of variation of 15% of the weight considered normal for men and women.	Individuals with associated psychiatric clinical conditions or other clinically unstable pathologies, alcohol and/or illicit substance abuse, gastrointestinal disease, pregnant or trying to get pregnant and individuals with surgery planned within the next 6 months were excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-5ch9crp	Effect of Magnesium Sulfate added to local anesthetic in the anesthesia for the arm	Data analysis completed	Intervention	2021-08-04	<NULL>	<NULL>	4813	Magnesium Sulfate as adjunvant to Bupivacaine in Supraclavicular Brachial Plexus Block: is it effective? - a randomized double-blind clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-12-21	Fundacao do ABC	Fundacao do ABC	https://ensaiosclinicos.gov.br/rg/RBR-5ch9crp	<NULL>	Patients with ASA classification PS1 and PS2; over 18 years of age; submitted to upper limb surgery with indication of supraclavicular brachial plexus block	presença de lesão de nervo periférico; doença cardíaca, hepática ou renal; vigência de tratamento com bloqueador de canal de cálcio; presença de distúrbios de coagulação ou uso de anticoagulantes; presença de infecção no local de punção; uso prévio de opioides; dificuldade para compreender a EVA (Escala Visual Analógica); alergia a anestésicos locais ou sulfato de magnésio; gestação;  peso corporal inferior a 40kg; falha total ou parcial do bloqueio sensitivo 35 minutos após a injeção; pósoperatório em unidade de terapia intensiva; necessidade intraoperatória de mudança da técnica anestésica devido a falha do plano anestésico	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-67m72sm	Effect of Magnetic Stimulation on Body Movement	Not yet recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9092	Influence of Transcranial Magnetic Stimulation on motor evoked potentials	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-05	Universidade Federal de Alfenas	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 30 and 75 years; diagnosis of left ischemic stroke confirmed by computed tomography or magnetic resonance imaging; between 3 weeks and 1 year post stroke; right upper limb motor preference assessed by the Edinburgh Handedness Inventory translated and validated into Portuguese with inclusion of only right handed participants with right hemiparesis and preserved right handgrip function; minimum score of 27 points in the upper limb domain of the Fugl Meyer scale	Left sided motor preference assessed by the Edinburgh Handedness Inventory; orthopedic disorders; contraindications to repetitive transcranial magnetic stimulation including personal or first degree family history of epilepsy or seizures presence of metallic implants or active electronic devices in the head or neck presence of cardiac pacemaker or implanted defibrillator; inability to understand written and spoken Portuguese; pain during task execution; difficulty performing handgrip or index finger flexion movements; failure to reach at least 70 percent of maximal voluntary isometric contraction	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-8g8ckzm	Effect of Magnetic Waves on postoperative pain control of foot and ankle surgery - clinical, controlled, randomized trial	Recruitment completed	Intervention	2024-04-03	<NULL>	<NULL>	8293	Effect of Peripheral Magnetic Stimulation on postoperative pain control of foot and ankle surgery - clinical, controlled, randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8g8ckzm	<NULL>	Individuals in the immediate postoperative period of foot and ankle surgeries; age greater than or equal to 18 years	Presence of other pain acute or chronic other than post-operative pain; malignant neoplasms; pregnancy; severe circulatory disease; severe neurological disease; severe cardiac disease; severe respiratory disease; severe orthopedic disease; infection; cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-6wbk5jg	Effect of Manual Myofascial Release thecnique on improving knee posture: a comparative study	Recruitment completed	Intervention	2021-06-08	<NULL>	<NULL>	4733	Effect of Manual Myofascial Release on reducing knee Hyperextension: a comparative study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6wbk5jg	<NULL>	To present knee hyperextension, initially assessed subjectively and later confirmed by photogrammetry as described below; and being 18 years of age or older.	Dermatological conditions that contraindicate the use of the myofascial release technique, such as dermatitis due to any cause; deep venous thrombosis and phlebitis; musculoskeletal disorders that generate changes in muscle tone; injury or previous surgery on the knee, ankle or hip.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-7t3j7x6	Effect of Manual Techniques on pain and movement in people with problems in the jaw region	Recruiting	Intervention	2025-09-01	<NULL>	<NULL>	8245	Effect of Manual Therapy on Pain Intensity and Mobility of Individuals with Temporomandibular Disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-04	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7t3j7x6	<NULL>	Age between 18 and 50 years; both genders; report pain greater than or equal to 4 on the Numerical Pain Scale (NPS greater than or equal to 4) in the temporomandibular joint region, not requiring clinical diagnosis, for a period equal to or greater than 3 months intermittently, that is, with intervals in which the pain ceases; pain/discomfort in the masseteric region and head and neck, associated with pain in the temporomandibular joint region, for a period equal to or greater than 3 months intermittently, that is, with intervals in which the pain ceases	Use any type of anti-inflammatory medication; use any type of orthodontic retainer plates	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-9zk7qx2	Effect of Manual Techniques on the cervical and lumbar spine on pain and joint range of motion in individuals with Neck Pain and Nonspecific Low Back Pain	Recruitment completed	Intervention	2023-08-23	<NULL>	<NULL>	6379	Effect of Myofascial Release, Manipulation and Joint Mobilization of the cervical and lumbar spine on pain and joint range of motion in individuals with Neck and Nonspecific Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Faculdade de Ceilândia da Universidade de Brasília	Faculdade de Ceilândia da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9zk7qx2	<NULL>	Age between 18 and 50 years old; gender masculine and feminine; medical and imaging diagnosis of non-specific low back pain; not using psychoactive or special control medication; not undergoing physiotherapeutic or similar treatment at the time of the research	Being pregnant; history of spine fracture and/or surgery; history of osteoporosis, disc disease with radiating pain, instabilities; presence of decompensated or untreated chronic diseases; history of tumor or cancer in the spine, pelvic organs and/or gastrointestinal tract; skin problems such as mycoses, recent injuries, psoriasis, cuts and dermatitis; other physical alterations that prevent carrying out the proposed treatments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-7s22c75	Effect of manual therapy associated with neck muscle exercise program and pain education in patients with migraine – a 3-Armed randomized clinical trial	Not yet recruiting	Intervention	2020-12-07	<NULL>	<NULL>	4872	Effect of manual therapy associated with neck muscle exercise program and pain education in patients with migraine – a 3-Armed randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7s22c75	<NULL>	Inclusion criteria: individuals of both sexes, aged between 18 and 55 years, diagnosed with migraine according to the 3rd edition of the International Classification of Headache Disorders, with at least 3 days of migraine per month, in the last month.	other concomitant primary / secondary headaches, including tension-type and cervicogenic headache; history of  facial or neck trauma; history of cervical disc herniation or cervical osteoarthritis; any systemic degenerative disease (for example: rheumatoid arthritis and lupus erythematosus); pregnancy; physiotherapy treatment for craniocervical dysfunction in the previous year; and / or who has started a new pharmacological treatment for the disease in the last three months prior to the screening of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-888vpty	Effect of Manual Therapy in singers with Reflux	Terminated	Intervention	2025-02-19	<NULL>	<NULL>	7768	Effect of Osteopathic Manual Treatment on Reflux symptoms in singers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Escuela de Osteopatia de Madrid Brasil	Escuela de Osteopatia de Madrid Brasil	https://ensaiosclinicos.gov.br/rg/RBR-888vpty	<NULL>	Singing individuals of both sexes will be admitted; with the diagnosis of reflux using the Reflux Symptom Index (RSI) questionnaire; be aged between 21 and 50 years; being an amateur singer complaining of reflux; being using or not taking medication for reflux; agree to the Free and Informed Consent Term (ICF)	The person who is an instrumentalist will be excluded; having trunk and/or head and/or neck surgery; having received osteopathic care in the last 3 months until the beginning of this research; being in speech therapy; use orthodontic appliance; have a diagnosis of hiatal hernia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-7yqk5p	Effect of manual therapy in subjects with cardiovascular disease	Not yet recruiting	Intervention	2019-08-09	<NULL>	<NULL>	2867	Autonomic responses of coronary patients submitted to a protocol of osteopathic techniques: a crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-15	Núcleo de Pesquisa do Instituto Docusse de Osteopatia e Terapia Manual	Núcleo de Pesquisa do Instituto Docusse de Osteopatia e Terapia Manual	https://ensaiosclinicos.gov.br/rg/RBR-7yqk5p	<NULL>	Men with a diagnosis of ischemic coronary disease; above 45 years of age; who do not present a history of smoking or alcoholism; cardiovascular rehabilitation program followers who do not present a historical recruitment period for infections; do not present with unstable angina; controlled hypertension; without significant valvular disease; without uncontrolled metabolic disease	Volunteers will be excluded from the study when time series records of RR intervals show less than 95% of sinus beats; absence of attendance in at least one of the stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-9d8ryw	Effect of manual therapy of the vagus nerve on pain and thoracic expansion in patients with neck pain	Not yet recruiting	Intervention	2019-04-22	<NULL>	<NULL>	2615	Effect of manual therapy of the vagus nerve on pain and thoracic expansion in patients with chronic non-specific neck pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Centro Universitário União das Américas - UNIAMÉRICA	Centro Universitário União das Américas - UNIAMÉRICA	https://ensaiosclinicos.gov.br/rg/RBR-9d8ryw	<NULL>	Aged between 18and 65 years; body mass index (BMI) &lt;30 kg / m², with neck pain for a period equal or greater than 3 months; a Portuguese-Brazilian version of the Neck Disability Index (NDI) score of 5 or higher and a Numeric Rating Scale (NRS) score of 3 or higher at rest or during active neck movement. The participant must be willing to participate in the study and sign the Informed Consent Term.	Participants are excluded if they had: bone diseases; bone fracture; history of tumor or cancer; cervical whiplash injury; history of neck trauma; previous spine surgery; have undergone physiotherapeutic or medical treatment for neck pain in the last 3 months prior to the study; using analgesic, anti-inflammatory and muscle relaxant medications during the week prior to the study; use of medications that could alter cardiac autonomic activity, such as (propranolol and atropine); systemic diseases; diagnosed fibromyalgia; diagnosed cardiovascular disease; orofacial pain; pregnancy; cervical radiculopathy; smoking; ethyl alcohol; diagnosed respiratory disease; diagnosed neuromuscular disease; and inability to perform the tests and answer the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-7q9hnmt	Effect of Manual therapy on Pain, Functionality and Health of the feet of recreational runners	Recruiting	Intervention	2024-03-20	<NULL>	<NULL>	6874	Effect of Myofascial Release on Pain, Functionality and Health of the feet of recreational runners	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7q9hnmt	<NULL>	Volunteers with pain in the forefoot, midfoot or rearfoot assessed by the visual analogue scale (VAS) greater than or equal to three; minimum running experience of at least six months; run at least 20 km per week	Volunteers who have contraindications to manual therapy such as tumors, fractures, rheumatoid arthritis, osteoporosis, severe vascular disease and local skin lesions; surgeries in the ankle and foot regions; diagnosis of fibromyalgia; diabetes; neuropathies; ankylosing spondylitis; difference of more than 1 cm in length between the lower limbs; pain assessed by the visual analogue scale (VAS) less than three; volunteers who are carrying out any types of specific treatments for the ankle and foot region, for example, manual therapy, shock waves, acupuncture and foot reflexology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-9g8585	Effect of manual therapy on the autonomic nervous system in chronic pain	Recruiting	Intervention	2020-05-22	<NULL>	<NULL>	3864	Effect of manual therapy on the vagus nerve pathway in the cardiac autonomic nervous system in individuals with chronic musculoskeletal pain: a controlled and randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Pedro Teixeira Vidinha Rodrigues	Pedro Teixeira Vidinha Rodrigues	https://ensaiosclinicos.gov.br/rg/RBR-9g8585	<NULL>	musculoskeletal pain for more than 3 months in any segment of the body and that fails the conditioned pain test by the cold pressor test.	individuals under 18 or over 60; who have a surgical procedure in the chest / spine region that prevents performing the proposed techniques; pregnant women; present rheumatological diagnosis in acute inflammatory phase; osteoporosis, primary bone tumors or not; presenting lymphedema in any member; having a pacemaker, having a cardiac arrhythmia or having a heart transplant; having eaten food and drinks containing caffeine on the day of the experiment; having drunk alcohol in the last 24 hours; use medications with a cardiac effect; unable to complete the self-administered questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-93xv9t	Effect of Manual Therapy Techniques on Limiting Ankle Dorsiflexion	Recruiting	Intervention	2020-09-04	<NULL>	<NULL>	4955	Immediate Effect of Two Manual Therapy Techniques on Limiting Ankle Dorsiflexion: A Randomized, Controlled and Blind Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-22	Faculdade de Educação Física e Fisioterapia - FAEFI/UFU	Faculdade de Educação Física e Fisioterapia - FAEFI/UFU	https://ensaiosclinicos.gov.br/rg/RBR-93xv9t	<NULL>	Individuals who have dorsiflexion values in a closed kinetic chain below 40 degress in the Lunge Test.	presenting musculoskeletal injury in the lower limb; rheumatic diseases; cardiovascular diseases; or any other alteration that may harm volunteers health or that compromises the performance of the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-6k7pkv	Effect of martial arts on cognition, physical abilities and school performance in students.	Recruitment completed	Intervention	2020-04-29	<NULL>	<NULL>	3788	Effect of a Martial Arts-Based Program on Cognitive Functions, Academic Performance, and Physical Ability in elementary school students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	GENSC - UFPE	Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-6k7pkv	<NULL>	Healthy volunteers; both genders; age between 8 and 12 years; enrolled in the educational institution of the study.	diagnosis of any physical limitation that prevents the intervention program and the physical test from being performed; have any psychological disorder or disorder that affects cognitive performance; diagnosis of eye diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-563h29	Effect of Massage Associated with Lavender Essential Oil on the Behavioral Context of Obese Women	Recruitment completed	Intervention	2020-09-23	<NULL>	<NULL>	4277	Effect of hot stone massage associated with lavender essential oil in the behavioral context of obese women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-06	Universidade Franciscana	Universidade Franciscana	https://ensaiosclinicos.gov.br/rg/RBR-563h29	<NULL>	Be woman; between 20 and 60 years of age; sedentary; presenting obesity with a BMI between 30 and 45 kg / m²; not using psychotropic drugs	Women who are using psychiatric drugs; psychological monitoring at the time of the evaluation; those who have an aversion to lavender essential oil	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-5h2yvf	Effect of maternal colostrum administration on oral mucosa of preterm infants on rates of late neonatal infection	Recruiting	Intervention	2018-09-27	<NULL>	<NULL>	3109	Impact of colostrum administration on the oral mucosa of preterm and very low weight on the sepsis rate: Randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-05	Universidade de Caxias do Sul	Hospital Geral de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5h2yvf	<NULL>	Newborns with gestational age equal to or less than 30 weeks and / or weighing 1,500 g or less; signing of the Informed Consent Form (TCLE) by the parents or guardians of the concept.	Newborns without child support during hospitalization; RN carriers of complex congenital malformations; neonatal problems that contraindicate colostrum; HIV positive mothers; mothers who use drugs and / or substance abuse that contraindicate the supply of breast milk; use of vasopressor drugs; RN from twin pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-5xgjwm	Effect of Maternal Supplementation with Vitamin A, offered at different intervals, on vitamin A concentrations in breast milk and on the nutritional status of the mother and baby	Data analysis completed	Intervention	2019-07-02	<NULL>	<NULL>	2794	Impact of Maternal Supplementation with Double Megadose of Vitamin A administered at different intervals on the composition of the mother&apos;s milk and nutritional status of the mother-child binomial	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2011-07-01	Universidade Federal de Pernambuco	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5xgjwm	<NULL>	Age between 18 and 40 years. Low obstetric risk	Diabetes. Hypertension. Neoplasms. Diseases of the gastrointestinal tract. Liver diseases. Cardiovascular diseases. Infectious diseases. Mental disorder. Preterm birth, Twin pregnancy. Congenital malformations. Cerebral palsy. Supplementation with vitamin A during gestation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-4v7j2d	Effect of maternal vitamin A supplementation on vitamins A and E in breast milk.	Recruiting	Intervention	2015-05-18	<NULL>	<NULL>	475	Assessment of maternal vitamin A supplementation on the retinol levels and alpha-tocopherol in human milk.	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	https://ensaiosclinicos.gov.br/rg/RBR-4v7j2d	<NULL>	Healthy volunteers; term delivery; conception without defect; aged 18-45 years; without a history of miscarriage; without the use of vitamin supplements during pregnancy containing vitamin A or E.	Premature birth; diagnosis of gastrointestinal, infectious, liver, heart, syphilis, HIV positive or neoplasms; conceptus multiple; with use of vitamin supplements during pregnancy containing vitamin A or E.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-5tbdpy5	Effect of Mechanical Ventilation Pressure Changes in Obese patients undergoing Laparoscopic Surgery	Not yet recruiting	Intervention	2024-01-29	<NULL>	<NULL>	6751	Effect of ventilatory strategy with Recruitment Maneuvers and PEEP Titration versus ventilatory strategy with Recruitment Maneuvers and 6 cmH2O PEEP versus ventilatory strategy without Recruitment Maneuvers and 6 cmH2O PEEP in Obese patients submitted to Videolaparoscopic Bariatric Surgery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Saullo Queiroz Silveira	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5tbdpy5	<NULL>	"Individuals aged 18 to 65 years old; American Society of Anesthesiologists Physical Status Classification System 2 or 3;
Body mass index ≥ 30 Kg/m2; Elective laparoscopic bariatric surgery; Elective robotic bariatric surgery"	American Society of Anesthesiologists Physical Status Classification System greater than or equal to 4; congestive heart failure; kidney failure; alcohol or drug abuse; allergy to study components; patients undergoing degastrectomy; patients undergoing combined surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-72mvv89	Effect of medication use after video-assisted nose surgery: experimental clinical study	Recruitment completed	Intervention	2025-01-16	<NULL>	<NULL>	7665	Effects of use of Intranasal Blue®M Solution in Post-Operative Endonasal Endoscopic Surgery: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Hospital Paranaense de Otorrinolaringologia	Hospital Paranaense de Otorrinolaringologia	https://ensaiosclinicos.gov.br/rg/RBR-72mvv89	<NULL>	Patients with chronic rhinosinusitis unresponsive to clinical drug treatment; patients with indication for endoscopic sinus surgery; older than 18 years	Patients who have a history of prior sinonasal surgery; patients with a history of smoking;  patients with a history of systemic diseases that compromise the airway or irregularities in mucociliary transport, such as asthma or cystic fibrosis; patients with upper airway infection during the three weeks prior to surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-42qj6vx	Effect of Meditation on women with Insomnia	Recruitment completed	Intervention	2024-09-04	<NULL>	<NULL>	7312	Effect of an Online Meditation Program on women with Insomnia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-28	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-42qj6vx	<NULL>	Women with insomnia; aged 18 to 47	Women who are already in the menopausal transition, that is, with an irregular menstrual cycle; women who declare that they have practiced some form of meditation and/or cognitive behavioral therapy for insomnia (CBT-I) in the last 2 months; women who have used medication for sleep and/or anxiety in the last month, such as: benzodiazepines, antihistamines, hypnotics, hypnotic herbal medicines, sedatives, antidepressants, antipsychotics, stimulants (amphetamine and modafinil) and corticosteroids; shift workers and illiterate participants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-4c37bch	Effect of Melatonin on anxiety before dentist appointment in children	Recruiting	Intervention	2024-11-04	<NULL>	<NULL>	7482	Effect of Melatonin on pre-consultation anxiety in pediatric dental care: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-29	Centro Universitário CESMAC	Centro Universitário CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-4c37bch	<NULL>	Children aged between 3 and 10 years; of both sexes; with physical status according to American Society of Anesthesiology (ASA) I and II; scheduled for dental care at Clinical School of Dentistry of the Centro Universitário Cesmac, PAM Salgadinho and Nutritional Recovery and Education Center	Children with mental disorders and disabilities that difficult them to understand commands; children have previously used anxiolytic and/or antipsychotic medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-8hqwmx	Effect of memory training allied to physical exercise in adult and elderly health parameters: association with genetic variables	Recruitment completed	Intervention	2018-11-08	<NULL>	<NULL>	2326	Effect of cognitive stimulation allied to physical training in adult and elderly health parameters: association with genetic polimorphisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-10	Escola de Enfermagem de Ribeirão Preto - Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8hqwmx	<NULL>	Healthy volunteers; both genders; 50 years or older and less than 80 years old.	Persons with a frequency of less than 75% in the activities proposed by the intervention; people with illness or mental disorder diagnosed; untreated systemic diseases that make participation impossible; uncorrected auditory and visual deficits that make cognitive tests impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-4rfcfgq	Effect of mental fatigue on visuomotor perfomance of martial arts athletes	Recruiting	Observational	2022-10-25	<NULL>	<NULL>	5682	Effect of prolongated cognitive effort and non-invasive brain stimulation on visuomotor perfomance of combat sports athletes	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4rfcfgq	<NULL>	Combat sport athletes; both sexes; age between 18 and 35 years; more than five years of experience in their modality; have competitive experience in their modality of origin in the last three years; be training the modality continuously in the last six months; have an active profile on Instagram	having suffered a knockout or concussion in the last month before the beginning of the collections; being on a low-calorie diet with restricted carbohydrate intake; impossibility of data analysis due to technical failures; self-reporting cognitive and brain impairment; present visual problems that compromise color discrimination; self-reporting sleep disturbances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-7dghjm	Effect of Mental Stress on vascular response in Resistant Hypertension	Recruiting	Intervention	2019-07-05	<NULL>	<NULL>	2802	The role of Nitric Oxide pathway on vascular response to Mental Stress in Treatment-resistant Hypertension	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-7dghjm	<NULL>	40 to 65 years; diagnosis of essential hypertension; adherence to the treatment confirmed; blood pressure of at least 140 to 85 mmHg despite treatment with three anti-hypertensive drugs; blood pressure less than 130 to 85 with the use of four or more antihypertensive drugs.	Secondary hypertension; diabetes mellitus; stage III, IV and V chronic kidney disease; coronary artery disease; cerebrovascular disease; hepatic insufficiency; ophthalmologic disorders; regular use of nitric oxide donor drugs; stimulators of guanylate cyclase; pregnancy or lactation; current abuse of alcohol or other drugs; severe past drug allergy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-8n8csf	Effect of Mesenchymal stem cells in patients with decompensated cirrhosis	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4177	Bone marrow mesenchymal stem cells in acute-on-chronic liver failure grades 2 and 3: a phase I-II randomized clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2018-09-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8n8csf	<NULL>	fulfilling ACLF diagnostic criteria and ACLF grade 2 or 3	patient’s or family member’s refusal; (b) hepatocellular carcinoma (HCC); (c) formal contraindicationfor liver transplantation (e.g. advanced heart or pulmonary disease); (d) pregnancy and lactation; (e) previous liver transplantation; (f) HIV co-infection; (g) ACLF grade 1; (h) patients admitted for elective procedures; (i) renal chronic disease requiring dialysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-7pjmj4	Effect of microcurrent on the tooth movement	Recruitment completed	Intervention	2020-01-06	<NULL>	<NULL>	3329	Effect of Low-Intensity Electrical Current on orthodontic movement acceleration and pain perception	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-14	Fundação Hermínio Ometto	Fundação Hermínio Ometto	https://ensaiosclinicos.gov.br/rg/RBR-7pjmj4	<NULL>	Adults with permanent dentition; caries free dentition and healthy periodontal structure; the presence of moderate to severe crowding in the anteroinferior region of the arches; non-concomitant use of analgesics and anti-inflammatories; voluntary participation in the study confirmed by the signature of the informed consent form.	Patients with missing teeth in the anterior-inferior region of the right premolar to the left premolar; individuals who present chronic or not chronic orofacial pain; patients whose informed consent was not obtained, patients in mixed dentition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-2tx7m8v	Effect of millet consumption on metabolic responses responses in adult subjects	Recruitment completed	Intervention	2023-06-26	<NULL>	<NULL>	6178	Effect of millet (Pennisetum glaucum (L.) R. Br.) consumption on metabolic responses responses in adult subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade Federal de Viçosa - Departamento de Nutrição e Saúde	Embrapa Agroindústria de Alimentos	https://ensaiosclinicos.gov.br/rg/RBR-2tx7m8v	<NULL>	Have normal blood glucose levels (fasting capillary glucose ranging from 70 to 99 mg/dL); regular breakfast intake; have a Body Mass Index (BMI) between 18.5 and 24.9 kg/m² and a body fat percentage between 20 and 30% for females and between 12 and 20% for males;  are between 18 and 60 years old; engage in light physical activity	Smokers; alcohol consumption exceeding 2 drinks per day (&gt; 50g of ethanol/day); presence of type 1 or type 2 diabetes or prediabetes (fasting blood glucose between 100 and 125 mg/dL); first-degree family history of diabetes mellitus; use of medications that affect blood glucose, energy metabolism, or appetite; use of medications, herbs, or diets for appetite and weight reduction; weight instability (gain or loss of approximately 3 kg in the 3 months prior to the start of the study); recent change in level of physical activity; aversion or intolerance to the foods provided in the study; presence or history of digestive, hepatic, renal, cardiovascular, thyroid, or recent inflammatory diseases; diagnosis of cancer in the previous year; history of eating disorders; and being pregnant or lactating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-83mmq5	Effect of mirror therapy associated with functional tasks in arm function after stroke	recruiting	Intervention	2011-07-07	<NULL>	<NULL>	157	Effect of mirror therapy associated with functional tasks in arm function after stroke: a randomised clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade do Estado de Santa Catarina	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-83mmq5	<NULL>	This will include individuals who suffered Stroke proven by CT scan or MRI for at least 6 months (chronic phase). Those with motor recovery level &gt; 30 (mild or moderate impairment) in the upper extremity section of the Fugl-Meyer motor assessment, scores on the modified Ashworth scale 2 or less for muscle groups evaluated (horizontal shoulder adductors, elbow flexors and wrist and finger flexors) and those able accomplish a task of handling rough (reach and grab a cylindrical object).	Will be excluded individuals with other neurological diseases, orthopedic problems in the upper limbs that interfere with the function of these, significant visual impairment not correctable, aphasia or difficulty to understanding simple tasks (eg reach and grasp a bottle); visual hemineglect verified through the Bells Test; members of other research or therapy involving the upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-27rmv3	Effect of mirror therapy in upper limb of young individuals with cerebral palsy and cerebral vascular accident	data analysis completed	Intervention	2012-05-08	<NULL>	<NULL>	131	Effects of mirror therapy in upper limbs of young individuals with hemiparesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-25	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-27rmv3	<NULL>	"Dysfunctional diagnosis of hemiparesis with brachial predominance; 
Medical diagnosis of Cerebral Palsy or Cerebral Vascular Accident, of prenatal or perinatal etiology; 
Age between 15 and 25 years;
Normal cognitive function."	"Visual and/or hearing impairment;
Mental deficiency; 
Muscular contractions that unable the execution of the tests;
Muscle tone of affected upper limb equal to or greater than 3 in the Ashworth Scale; 
Botulinum toxin  injections and/or surgery during the previous 6 months;
Subjects who do not accomplished 25% or more of the intervention sessions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-5hm95cw	Effect of mobile app on Self-efficacy and prevention of breastfeeding difficulties.	Not yet recruiting	Intervention	2021-09-17	<NULL>	<NULL>	4897	Effect of mobile app on breastfeeding self-efficacy and prevention of breastfeeding complications: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-16	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-5hm95cw	<NULL>	Postpartum women admitted to the maternity room together with their baby; over 18 years of age; literate; who have a smartphone; and who express an interest in breastfeeding.	Women unable to breastfeed for clinical reasons (cases of HIV, cytomegalovirus and/or HTLV), who gave birth to multiple babies, who had a premature birth (&lt;37 weeks) or with a history of hospitalization of the newborn in the ICU.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-5skmvw	Effect of mobilization of the temporomandibular joint and hyoid bone in the neck system: controlled randomized clinical trial	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	1001	Craniocervicomandibular system : evaluation methods and multimodal therapeutic intervention	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5skmvw	<NULL>	Women; have TMD diagnosis as the RDC / TMD instrument; Temporomandibular index greater than 0.5 ; belong to age group 18-40 years; patients able to understand commands ; are willing to participate in the study by signing the free and informed consent.	Fracture or previous surgery in orofacial or cervical region; a neurological disorder or neoplastic disease in the craniocervical region; irritable nerve compression evidence assessed by neural tests for the median, radial and ulnar ; They are making use of medications during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-5d7hkv	Effect of Moderate Physical Training on a bicycle associated with altitude simulation on the health status of people recovered from COVID-19 (AEROBI-COVID)	Recruiting	Intervention	2020-11-03	<NULL>	<NULL>	4362	Effect of Moderate-Intensity Training associated with normobaric hypoxia on lung function, hematological, immunological, autonomic parameters and related to physical fitness in convalescent people from COVID-19 (AEROBI - COVID)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-11	Escola de Educação Física e Esporte de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5d7hkv	<NULL>	Participants women and men aged between 30 and 69 years convalescent from COVID-19 (having the test with a positive diagnosis); having moderate to severe symptoms; approximately 30 days since recovery from clinical signs or medical discharge (if you have been hospitalized); have previous experience in aerobic physical activity.	Exposure to high places (altitude greater than 1500 m) in the last three months; significant physical limitations to carry out evaluations and intervention; acute or chronic clinical illnesses without medical supervision; anemia; use of immunosuppressive drugs; pregnant women; hormone replacement; smokers; excessive use of alcohol or drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-25rft3r	Effect of moderate-paced music on walking ability and muscle metabolism in people with Peripheral Arterial disease	Not yet recruiting	Intervention	2025-04-23	<NULL>	<NULL>	7946	Effect of medium-pace music on walking ability and muscle metabolism of claudicating individuals with Peripheral Arterial disease: a quasi-experimental study	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-25rft3r	<NULL>	Homens e mulheres; Age ≥ 18 years; Diagnosis of peripheral arterial disease with ankle-brachial index &lt; 0.90 at rest; Individuals without physical and cognitive limitations for performing and understanding the procedures; In case of hearing impairment, the participant may only participate if they have correction by a prosthesis that guarantees their exposure to sound stimuli	Participants with clinical conditions that contraindicate physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7cz4sf	Effect of motor and cognitive training of the elderly in relation to the ability to perform daily tasks	Data analysis completed	Intervention	2020-09-23	<NULL>	<NULL>	4278	Effect of Motor-cognitive training (dual task) on the functionality of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7cz4sf	<NULL>	Independent participants in the execution of the march; classified in stages 2 and 3 on the Hoehn and Yahr&apos;s Disability Scale; have preserved capacity for recognizing shapes and numbers; be able to sequence shapes and numbers proposed by the intervention	Participants who needed any kind of assistance to carry out the march; carriers of diseases that would prevent testing; those who were undergoing physiotherapeutic treatment or who were in a long-term institution	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-6r7ww5	Effect of muscle endurance training in elementary public school teachers	Data analysis completed	Intervention	2012-02-29	<NULL>	<NULL>	1749	The chronic effect of stretching taken before or after exercise for hamstrings on musculoskeletal symptoms in a group of public school teachers of Matinhos-PR	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-25	Universidade Federal do Paraná Setor Litoral	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6r7ww5	<NULL>	"Effective municipal elementary school teachers, working in classrooms, directly with the students;
General health condition;
Sedentarysm for at least eight weeks."	"Teachers retired; 
Current pathology or early that prevented evaluations and/or exercises; 
Participated in other programs that included physical exercises and evaluations that were incomplete data."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-5dxr6cq	Effect of Muscle Strengthening by Distance Care: Randomized controlled trial	Recruitment completed	Intervention	2025-02-26	<NULL>	<NULL>	7808	Effect of Teleservice Strength Training. Randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-14	Universidade Federal de Alfenas - UNIFAL-MG	Universidade Federal de Alfenas - UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-5dxr6cq	<NULL>	Participants with self-report of low back pain; of both sexes; aged between 18 and 30 years	Age less than 18 years and over 30 years and presenting a medical diagnosis of neurological; orthopedic; traumatological; rheumatological diseases that promote alterations in static balance or cause chronic pain; participants with uncontrolled arterial hypertension; skin lesions in the lumbar spine/lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-22y7p9	Effect Of Muscle Strengthening on The Upper Limb Motor Recovery After Stroke	Data analysis completed	Intervention	2013-03-07	<NULL>	<NULL>	318	Effects of Functional and Analytical Strength Training on Upper-Extremity Motor and Functional Recovery After Stroke: a Randomized, Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Hospital Mãe de Deus	https://ensaiosclinicos.gov.br/rg/RBR-22y7p9	<NULL>	six months to five years since the onset of a unilateral stroke; ability to comprehend simple instructions (Mini-Mental State Examination with a minimum score of 20); no pain, contractures, or severe weakness in shoulder flexion muscles (&lt; 3 in the Manual Muscular Testing); and no upper-limb rehabilitation during this research.	other neurological, neuromuscular, or orthopedic disease; severe comorbidity diseases; or severe increase of upper extremity muscular tone(&gt; 3 points according to the modified Ashworth scale).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-965656g	Effect of muscle training on pain and functionality in elderly people with knee wear	Recruitment completed	Intervention	2022-06-10	<NULL>	<NULL>	5426	Effect of Training Protocols on Chronic Pain and Physical Function in Older People witjh Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-27	Carla Mariza de Lima Krieger	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-965656g	<NULL>	Volunteers of both genders; be 60 years of age or older; be able to perform physical exercises, according to medical evaluation; having knee osteoarthritis in one or both knees (according to the American College of Rheumatology); present grade ≤ 3 according to the Kellgren-Laurence Grading Scale (Kellgren et al., 1957); refer chronic pain for more than 3 months (according to the IASP - International Association for the Study of Pain concept) in one or both knees, with referred pain ≥ 3, according to the Visual Analogue Scale (VAS).	Pacemaker wearers; having fibromyalgia; carrier of any oncological disease; having some systemic/general and/or cognitive impairment or neurological disorder; having undergone knee surgery and/or intra-articular corticosteroid injection within 6 months; any other muscular, joint or neurological condition that affects the function of the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-6wvd9t	Effect of Muscular Strengthening in different positions on hip muscle stiffness and hip and knee and foot movement in healthy and sedentary adults	Recruiting	Intervention	2019-07-17	<NULL>	<NULL>	2820	Effect of Muscular Strengthening on different ranges of motion on passive stiffness of lateral hip rotators and lower limb kinematics of healthy and sedentary adults a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-6wvd9t	<NULL>	Young. Sedentary. Healthy adults, eighteen years of age or older, who have a range of medial hip rotation of at least twenty-five degrees and lateral hip rotation of at least five degrees. Perform less than thirty minutes five days a week of moderate intensity aerobic activity, twenty minutes on three days per week of aerobic activity of vigorous intensity. Perform less than two days per week of muscle strengthening or endurance activities. Have not undergone surgical procedures or hip rehabilitation or suffered musculoskeletal injury to the lower limbs / trunk in the last six months.	Inability to perform the tests. Presence of muscle contraction during the passive stiffness test of RL of the hip. Pain reported during the procedure that prevents its correct execution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-10qchkrp	Effect of music as complementary therapy in bed bath in patients after orthopedic surgery: Randomized Clinical Trial	Recruiting	Intervention	2024-10-31	<NULL>	<NULL>	7474	Effect of music as Complementary Therapy in bed bath in patients in the Postoperative period of Orthopedic Surgeries: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Centro Universitário FMABC	Centro Universitário FMABC	https://ensaiosclinicos.gov.br/rg/RBR-10qchkrp	<NULL>	Patients on the first and second postoperative day who underwent orthopedic surgeries; Patients of both sexes over the age of 18 years in the postoperative period of orthopedic surgeries receiving analgesia; Patients who will undergo bed bath without scalp hygiene	Patients with hearing impairment; Patients who are capable of being sent to the spray bath or who will undergo the bed bath procedure with scalp hygiene; Patients with a Glasgow Coma Scale result greater than 14; Patients who do not like music or associate music with negative experiences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-3t3qwp7	Effect of Music in Pain Relief during the removal of the cannula inserted in the femoral artery after Cardiac Catheterization: a randomized clinical trial	Recruiting	Intervention	2022-05-04	<NULL>	<NULL>	5378	Efficacy of Music in Pain Relief during the femoral arterial introductor withdrawal after Cardiac Catheterism: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-25	Rodrigo Assis Neves Dantas	Rodrigo Assis Neves Dantas	https://ensaiosclinicos.gov.br/rg/RBR-3t3qwp7	<NULL>	Patients admitted to hemodynamics for cardiac catheterization with the need to remove the arterial introducer via the femoral route; elective procedures; age 18 years or older.	Not liking music; patients who have already undergone the aforementioned procedure; presence of chronic pain; previous analgesia; individuals with some neurological and/or cognitive problem that compromise the understanding and use of the scale at the appropriate time; hearing impaired individuals.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-3rckr6	Effect of music in reducing women&apos;s stress at the time of the uterine cancer screening	Recruitment completed	Intervention	2020-02-24	<NULL>	<NULL>	3525	Potential of musical auditory stimulus in stress reduction in women submitted to cervical cytopathological examination	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-12	Universidade Regional do Cariri-URCA	Universidade Regional do Cariri-URCA	https://ensaiosclinicos.gov.br/rg/RBR-3rckr6	<NULL>	"Volunteers aged 25 to 40 years; body mass index between 18.5 and 30 kg / m²; undergoing follow-up Pap smear, ie
be undergoing the second or third collection, discarding the first time"	volunteer smokers; who are diagnosed with cardiorespiratory, neurological or hormonal disorders due to climacteric; taking medications that influence cardiac autonomic regulation; pregnant women; with hearing disorders and women who consumed alcohol in the 12 hours prior to the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-8w2wr4y	Effect of Music on Pain Relief During Arterial Introducer Removal via Femoral Route	Not yet recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8734	Effect of music on pain relief during femoral arterial introducer withdrawal: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Departamento de Enfermagem da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Patients admitted to the hemodynamics unit of the Onofre Lopes University Hospital for cardiac catheterization or arteriography of the lower limbs; need for removal of an arterial introducer via the femoral approach; elective procedures; individuals aged 18 years or older	Dislike of music; patients who have undergone cardiac catheterization or arteriography of the lower limbs; presence of chronic pain; previous analgesia; individuals with any neurological and/or cognitive problem that compromises the understanding and use of the scale and data collection instruments; individuals with hearing impairment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-85gzsj	Effect of Music on Weight Gain of Premature Infants	Data analysis completed	Intervention	2015-05-26	<NULL>	<NULL>	488	The effect of Music on weight gain of Premature hospitalized infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-26	Universidade Federal de São Paulo	Maternidade Escola Santa Mônica	https://ensaiosclinicos.gov.br/rg/RBR-85gzsj	<NULL>	"Preterm infants with post-conceptional age greater than or equal to 32 weeks.
Normal hearing by evoked otoacoustic emissions bilaterally.
Normal vision by visual assessment and examination of the fundus bilaterally"	"Presence of severe hypoxia, intracranial hemorrhage, pulmonary,cardiac, and neurological problems, malformations and syndromes
Presence of clinical complications during the study period, as signs of respiratory distress, diarrhea or reflux"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-8s56by	Effect of musical stimulation associated with Physiotherapy on the movement of sedentary elderly	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4039	Effect of Rhythmic Auditory Stimulation associated with Physiotherapy on the functional mobility of sedentary elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-04	Camila Maria Mendes Nascimento	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8s56by	<NULL>	"Patients aged 60 years or older; sedentary;
with the ability to move independently; lack of medical contraindications for physical exercise; ability to understand instructions and active participation in tasks, considering the scores of the Mini Mental State Examination (MMSE) corresponding to their schooling; visual acuity confirming through the Snellen Signal Scale; hearing acuity verified through the whisper test"	Patients with neurological diseases; orthopedic, rheumatic and  or vascular pathology, with moderate or severe functional restriction in one or both lower limbs;history of fracture in the last year; hypertension and or uncontrolled heart disease; limiting visual and or auditory compromises for the execution of the protocol; amputee, prosthesis and lower limb orthosis users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-37428y	Effect of myofascial massage on voice, breathing and body posture of female teachers - randomized controlled clinical trial	Recruiting	Intervention	2018-09-19	<NULL>	<NULL>	2215	Effects of Myofascial Release Therapy on voice, breathing and body posture of teachers with Musculoskeletal and Vocal complaints: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Pós Graduação Distúrbios da Comunicação Humana da Universidade Federal de Santa Maria	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-37428y	<NULL>	active teachers at all levels of education; in the age group of 19 to 60 years; with normal larynx or the following laryngeal (LA) conditions: triangular crevice of degree I or degree II; presence of musculoskeletal and / or vocal complaints.	professor of Brazilian Language of Signs, support rooms, singing and or music; Physical Education or in administrative activities; history of neurological, gastric, psychiatric, endocrinological, rheumatic, musculoskeletal, degenerative or pulmonary diseases; Hearing Loss; orthopedic trauma or craniofacial malformations, whiplash injury, neck surgical scars, radiotherapy and laryngeal surgery; under phonoaudiological, physiotherapeutic and / or otorhinolaryngological treatment; amateur or professional singer; habits of alcoholism and / or smoking; diagnosis of dysphonia or other AL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-2b7kss	Effect of myofascial release in persons with Parkinson&apos;s Disease	Recruiting	Intervention	2017-05-19	<NULL>	<NULL>	1239	Acute effects of myofascial release on cardiorespiratory variables in persons with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-2b7kss	<NULL>	Volunteers with clinical diagnosis of Parkinson&apos;s disease; both genders;with scores between 1 and 3 on the Hoehn and Yhar scale.	Volunteers with signs of dementia; cardiorespiratory diseases; neuromuscular diseases; musculoskeletal diseases not related to Parkinson&apos;s disease; to have made changes in the class and/or drug dose between the evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7s58x6v	Effect of Myofascial Release on Post-Exercise Recovery in Water Polo Athletes	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7706	Effect of Release of Trigger Points on Functional Capacity, Biomechanical and Physiological Variables in Recovery After Game Simulation in Water Polo Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Centro Universitário do Sagrado Coração - UNISAGRADO	Centro Universitário do Sagrado Coração - UNISAGRADO	https://ensaiosclinicos.gov.br/rg/RBR-7s58x6v	<NULL>	(a) male athletes; (b) age 16 to 25 years old; (c) have at least one year of experience in the sport; (d) perform a training load of at least 10 hours per week in the sport; (e) participate in at least regional level competitions	(a) have no reports of muscle injury in the thigh in the three months prior to the study, (b) joint injuries in the hip, such as femoroacetabular impingement or tendinopathies of the tendons of the hip muscles or trochanteric, iliopectineal or ischial bursitis diagnosed by a clinician; (c) do not present a drop in performance for more than four weeks that could characterize the occurrence of non-functional overreaching or signs of overtraining syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-44h66b	Effect of nasal lavage with Budesonide diluted in large volume for the clinical treatment of patients with Chronic Rhinosinusitis with nasal polyps	Recruiting	Intervention	2020-07-22	<NULL>	<NULL>	4029	Efficacy of adding high volume diluted Budesonide nasal lavage for maximum clinical treatment in patients with Chronic Rhinosinusitis with polyposis: double-blind, randomized, controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-07	Clinica Olfact	Clinica Olfact	https://ensaiosclinicos.gov.br/rg/RBR-44h66b	<NULL>	Patients with a minimum nasal polyp score (SPL) of 5 out of a maximum of 8 for both nostrils (with at least a score of 2 for each nostril); Presence of at least two of the following symptoms before screening: nasal block, obstruction, congestion or rhinorrhea (anterior or posterior); facial pain / pressure; reduction or loss of smell	Patient under 18 years old, or over 55 years old; SNOT-22 with a sum of less than 7; Patients who used drugs or therapies that interfere with the results of this clinical trial, within 2 months before screening: treatment with immunosuppressants; anti-immunoglobulin medications and within two months before screening; Start of allergen immunotherapy in the 3 months prior to the first consultation or a plan to start therapy during the screening period or the randomized treatment period; Patients who have undergone any nasal surgery; Patients using anti-leukotrienes and antihistamines; Asthmatic patients will be excluded if: the forced expiratory volume (FEV1) is 60% of predicted or less; there has been an exacerbation requiring systemic steroidal treatment (oral and / or parenteral) or hospitalization for more than 24 hours for the treatment of asthma, in the 3 months prior to screening; use of a dose greater than 1000 mg of inhaled fluticasone or equivalent; Patients with short life expectancy (less than 6 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-2h3d6b	Effect of nebulized saline on mucociliary transport	data analysis completed	Intervention	2012-01-04	<NULL>	<NULL>	57	Effect of Nebulisation on the Mucociliary Nasal Transport	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Faculdade de Medicina de Ribeirão Preto	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2h3d6b	<NULL>	Volunteers aged between 18 and 30 years old were selected amongst the Ribeirão Preto School of Medicine undergraduate and post-graduate students for study	Those with smoking habits, cystic fibrosis, sinusitis, rhinitis, ciliary dyskinesia, hypertrophy of lower turbinates, major septal deviation, upper and lower airways infections in the last four weeks prior to study, bronchiectasis, and individuals who underwent surgery in the upper airways were excluded from study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-6rtcvb	Effect of neural mobilization and self-mobilization in the flexibility of the hamstrings in elderly women	Data analysis completed	Intervention	2015-02-20	<NULL>	<NULL>	397	Effect of neural mobilization and automobilization in hamstring flexibility in older	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Associação Teresinense de Ensino SC LTDA	Centro de Convivência da Terceira Idade	https://ensaiosclinicos.gov.br/rg/RBR-6rtcvb	<NULL>	The elderly From 60 years; attendance NAS activities developed in the Social Center of the Third Age ; Consent to Participate in Study.	Presence of severe joint deformities or traumatic orthopedic origin; acute inflammatory diseases ; Deep vein thrombosis ; neurological signs, lack of cooperation in the procedures that were performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-3wwt53	Effect of neural mobilization on the vertical jump and balance in healthy subjects	not yet recruiting	Intervention	2012-06-05	<NULL>	<NULL>	119	Effect of neural mobilization in the lower limbs on the vertical jump and balance in healthy subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-20	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3wwt53	<NULL>	Men and women, aged between 18 and 45 years, that do not have previous neurological or vestibular disorders, musculoskeletal or any change that interferes with or contra-indicate the measurement procedures of this study	Underage individuals and individuals with vestibular disorders, neurological or musculoskeletal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-2nt4byr	Effect of Neuromodulation and Virtual Game on Cardiac Variation in Women with Fibromyalgia – a clinical trial	Recruitment completed	Intervention	2024-05-23	<NULL>	<NULL>	7021	Effect of combined transcranial direct current stimulation therapy and virtual reality on cardiac autonomic modulation in women with fibromyalgia - a double blind randomized clinical trial with crossover	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-18	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-2nt4byr	<NULL>	As inclusion criteria, was considered: women diagnosed with FM, aged between 30 and 50 years, who did not use medications that could interfere with the variables studied, such as cardiac beta blockers, and who signed the free and informed consent form.	As exclusion criteria: non-understanding of the task, assessed through the participant&apos;s ability to perform the task correctly after performing three attempts with explanation and demonstration by the evaluator.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-7xhvw6n	Effect of Neuromodulation associated with Gametherapy on upper limb function and brain activity in children with Down Syndrome: double-blind, placebo-controlled, crossover clinical trial	Not yet recruiting	Intervention	2022-11-08	<NULL>	<NULL>	5710	Effect of Transcranial Direct Current Stimulation associated with Gametherapy on function, upper limbs reaching movement and brain activity in children with Down Syndrome: crossed, placebo-controlled and double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-10	Universidade Evangélica de Goiás	Universidade Evangélica de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7xhvw6n	<NULL>	Diagnosis of Down Syndrome; adequate understanding and cooperation during proceedings;age between six and twelve years; impairment of upper limb motor coordination and declaration of free and informed consent signed by a legal guardian; neurotypical; adequate understanding and cooperation during proceedings; age between six and twelve years; declaration of free and informed consent signed by a legal guardian, consent form signed by the child.	Children who have undergone surgical procedures in the twelve months prior to the beginning of the training sessions; orthopedic deformity of the lower limbs or spine with surgical indication; uncontrolled epilepsy; metallic implant in the skull or hearing aids; associated neurological disorder; and pacemaker use; associated neurological disorders, bone deformity in the lower and upper limbs, uncorrected visual deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-9y296bt	Effect of Neuromuscular Electrical Stimulation of the Quadriceps on Pain and Functional Physique of Elderly Women with Knee Osteoarthritis Feasibility Study	Recruitment completed	Intervention	2023-11-17	<NULL>	<NULL>	6584	Effect of Neuromuscular Electrical Stimulation of the Quadriceps on Pain and Functional Physique of Elderly Women with Knee Osteoarthritis Feasibility Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-20	Universidade Federal do Amazonas	Associação do Idosos do coroado (ASSIC)	https://ensaiosclinicos.gov.br/rg/RBR-9y296bt	<NULL>	age between 60 and 79 years old; diagnosis of knee osteoarthritis by a medical doctor; with history, physical examination and radiographic findings; Radiography in the last 12 months showing grade 2 or 3 osteoarthritis (OA) based on radiographic classification	use of a pacemaker and unstable heart conditions (coronary artery disease, valvular heart disease, cardiomyopathy, myocarditis); neurological or cognitive disorders; participation in another physical activity program in addition to the activities of the Associação de Idosos do Coroado (Assic) or physiotherapeutic treatment in the last 3 months; not being able to walk without assistance; skin lesion at the site of application of neuromuscular electrical stimulation; have contraindications clinically determined by a medical doctor to participate in the experiment; previous musculoskeletal surgery or joint injuries other than knee osteoarthritis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-38kgxy	Effect of Neuroscience Education in Pain combined to Pilates in Catastrophization for Elderly with non-specific Chronic Low Back Pain: A Randomized Controlled Trial	Data analysis completed	Intervention	2019-01-03	<NULL>	<NULL>	3071	Pain Neuroscience Eucation for the older people with chronic low back pain: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-11	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-38kgxy	<NULL>	"Participants will be recruited from the municipality of São Carlos through advertisements in the community and media.
Individuals aged 60 years or older with non- specific chronic low back pain who score the minimum score according to schooling in the Mini Mental State Examination MMSE and do not present depressive symptoms in the Geriatric Depression Scale GDS-15.For the classification of chronic pain was used the criteria of the International Association for the Study of Pain IASP, which recommends that, for research, the chronicity of pain is defined as lasting more than six months (IASP, 2015)."	All older people that have undergone physical therapy for pain management within 6 months prior to the intervention, or undergone surgical treatment for CLBP were excluded, involvement in regular sports activities that have the same physical benefits as Pilates, such as improved muscle strength and stretching. Those with diagnosis of central sensitization syndromes (such as fibromyalgia), cancer and active inflammatory diseases, or with pain associated to previous spine or lower limbs fracture, and those that already regularly performed physical activities with therapeutic aims of stretching and strengthening similar to Pilates will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-4qb9bqy	Effect of new dentures on the appearance of the face in people without teeth	Recruitment completed	Intervention	2026-02-09	<NULL>	<NULL>	8849	Effect of new complete dentures placement on facial parameters in complete denture wearers	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Completely edentulous patients; of both genders; over 18 years of age; requiring new complete dentures; in good general health; without intraoral lesions or pathologies; without alterations in the perioral musculature upon palpation	Patients with health problems that may hinder or prevent attendance at the dental school for prosthetic treatment, follow-up appointments, or study evaluations; with severely resorbed ridges; with palatal tori requiring surgical removal	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-10cwcpzj	Effect of nitrate on circulation and muscular endurance in humans	Recruiting	Intervention	2025-01-07	<NULL>	<NULL>	7645	Effect of inorganic nitrate on microvascular function, angiogenesis and muscle endurance in healthy humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-10cwcpzj	<NULL>	Healthy adults; of both sexes; with a minimum age of 18 years and a maximum age of 40 years; non pregnant; people who are available to participate in all visits to carry out the study; people from other cities who are available to be in the city where the experiments will be carried out	Individuals with cardiovascular diseases; pulmonary diseases; diabetes mellitus; hypertension; dyslipidemia; smoking; urinary tract infection; breastfeeding women; people who use drugs that interfere with amino acid metabolism and NO production; presence of osteomyoarticular injuries; use of nutritional and pharmacological ergogenic aids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-8g25rh4	Effect of non-invasive Brain Stimulation on functionality and concurrent tasks in people with Diabetes Mellitus: a randomized clinical trial	Not yet recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6329	Effect of Transcranial Direct Current Stimulation on functional performance and dual task of individuals with Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal do Amazonas	Faculdade de Educação Física e Fisioterapia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8g25rh4	<NULL>	adults; not elderly; diagnosed with Type 2 Diabetes Mellitus; able to walk independently without the use of a walking aid; no history of diabetic neuropathy; vestibulopathy; retinopathy; nephropathy; neurological or orthopedic disease that affects gait quality, such as poliomyelitis; Brain stroke; parkinson, cerebellar ataxia; lower limb fracture; knee or hip replacements; congenital clubfoot; Charcot arthropathy; lameness of any etiology	presence of plantar ulcers; diagnosis of epilepsy; materials surgically implanted in the head or neck; use of psychotropic medication; known allergies to tDCS preparation materials; history of psychiatric illness or previous neurosurgical procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-107sy4gq	Effect of Non-invasive Electrical Stimulation applied over the head on the resistance to fatigue of the Biceps brachii muscle in older people	Recruitment completed	Intervention	2021-09-09	<NULL>	<NULL>	6457	Effect of Transcranial Direct Current Stimulation (tDCS) on the resistance to fatigue of the Biceps brachii muscle of older adults: a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-107sy4gq	<NULL>	Elderly between 60 and 75 years of both sexes; hemodynamically stable according to the guidelines of the Brazilian Society of Cardiology (BP &lt; 140mmHg x 90mmHg) or (BP &gt; 90mmHg x 60mmHg) (Brazilian Society of Cardiology); active in relation to Resistance Training in the minimum six months; able to perform the exercise at 80% of 1RM (1 maximum repetition) in the Scott curl; performing at least ten repetitions of this exercise; having received the second dose of the COVID-19 vaccine.	Elderly people who have a cut-off score of less than 14 in the Mini-Mental State Examination (MMSE); having uncontrolled arterial hypertension; acute or chronic pain in the upper limbs; contraindication to the use of Transcranial Continuous Current Stimulation such as a history of recurrent seizures, tumors or skin infection at the stimulation site and any metallic material implanted in the brain, use of a pacemaker or metallic implant in the head; presenting sequelae of COVID-19 such as fatigue, cardiopulmonary or musculoskeletal disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-3mywq86	Effect of Non-Invasive Neuromodulation in improving balance and gait of individuals with Parkinson´s disease	Data analysis completed	Intervention	2022-08-26	<NULL>	<NULL>	7129	Effectiveness of Transcranial Direct Current Stimulation associated with Physiotherapy in improving balance and gait of individuals with Parkinson´s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-30	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-3mywq86	<NULL>	Medical diagnosis of Parkinson&apos;s disease according to the criteria of the London Brain Bank (Uk Parkinson&apos;s Disease Society Brain Bank Clinical Diagnostic Criteria); age range between 50 and 85 years; not institutionalized; mini-mental score that does not characterize cognitive impairment; Hoehn&amp;Yahr scale between 1.5 and 3.0; which accept to participate of the project and sign the consent term according to the criteria of the Ethics Committee of the Universidade Estadual de Londrina, according to the parecer 466/2912 (National Health Council)	Individuals who perform another therapeutic treatment beyond medication; that has change in medication during the study; or those with associated diseases, such as neurological disorders, severe heart disease, amputations, cognitive or understanding deficits. Change in the stabilization of the antiparkinsonian medication doses throughout the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-5r8syp	Effect of nursing care on prevention of dry eye in adult patients admitted to the Intensive Care Unit	Not yet recruiting	Intervention	2016-04-29	<NULL>	<NULL>	822	Randomized clinical trial: effect of nursing interventions on prevention of dry eye in critically ill patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Escola de Enfermagem da Universidade Federal de Minas Gerais	Santa Casa Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-5r8syp	<NULL>	"Be over 18 years;
did not present dry eye at the time of admission;
stay in the ICU for at least 24 hours;
be in mechanical ventilation therapy;
glance less than 5 per minute;
comatose, sedated or Glasgow less than or equal to 7; 
consent to participate in research or have."	"Have not the responsabille authorization;
Patients with severe eye disease or with history of adverse effects after use of any of the interventions proposed and not tolerate the treatment: artificial tear gel, artificial tear liquid and saline 0.9%."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-2g463ss	Effect of Nursing Consultation based on Orem&apos;s model in self-care agency and adherence to treatment of elderly people with HIV	Recruitment completed	Intervention	2023-11-17	<NULL>	<NULL>	6583	Effect of nursing consultation based on the Orem model on health parameters in people with neurocognitive changes associated with HIV/AIDS	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-05	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2g463ss	<NULL>	Patients aged 50 years or older treated at the infectology outpatient clinic for at least 6 months	Patients with some physical or mental disability and patients who do not attend the next stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-5m5qg83	Effect of nursing consultation based on the supported self-care technique on treatment adherence of patients with high blood pressure	Data analysis completed	Intervention	2021-08-20	<NULL>	<NULL>	4845	Effect of nursing consultation based on self-supported care on therapeutic adherence of hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Universidade de Pernambuco	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5m5qg83	<NULL>	Age 18 years or older; confirmed medical diagnosis of arterial hypertension; antihypertensive treatment for at least six months; monitoring with a professional nurse in the ESF, residing in the coverage area of ​​the selected health units.	People with cognitive impairment to answer questionnaires about aspects of memory, attention and communication skills; pregnant women with hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-8bvqz2	Effect of nursing interventions using the telephone	Recruiting	Intervention	2015-02-26	<NULL>	<NULL>	408	Effectiveness of nursing interventions using the telephone	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-24	Escola de Enfermagem da Universidade de São Paulo-EEUSP	Escola de Enfermagem da Universidade de São Paulo-EEUSP	https://ensaiosclinicos.gov.br/rg/RBR-8bvqz2	<NULL>	Being a family caregiver of a person with chronic illness; aged over 18 years; reading and writing,to have a longer than a month taking care of the family; to  have telephone service, to have a nursing diagnosis Caregiver Role Strain	Caregiver with cognitive impairment, assessed by the Mini Mental State Examination (MMSE) test;to have limitations for speech and hearing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-46n583h	Effect of Nutrisus in preventing anemia in children under six years old	Recruitment completed	Intervention	2022-09-21	<NULL>	<NULL>	5621	Acceptability and effectiveness of Nutrisus in the prevention of anemia and iron deficiency in children under six years old	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Ana Paula Grotti Clemente	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-46n583h	<NULL>	Children aged 1 to 6 years enrolled at Centro de Recuperação e Educação Nutricional who are not using iron supplementation at the time of recruitment	Children diagnosed with neurological or hematological diseases of genetic and autoimmune origin (sickle cell, hemolytic, sideroblastic and aplastic anemia, Fanconi anemia and thalassemia), who use iron supplementation at the time of recruitment, or with a diagnosis of anemia due to other nutritional causes: megaloblastic and pernicious anemias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-6bp3hk	Effect of Oat supplementation and Physical Activity on glucose and cholesterol control and weight loss in the elderly	Recruitment completed	Intervention	2020-08-27	<NULL>	<NULL>	4183	Effect of oat consumption and physical activity in the elderly in Mossoró / RN	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Paloma Katlheen Moura Melo	Paloma Katlheen Moura Melo	https://ensaiosclinicos.gov.br/rg/RBR-6bp3hk	<NULL>	The study included: 60 elderly people, aged 60 to 90 years, of both sexes; with a higher / equal score of 17 points in the Mini-Mental State Examination (MMSE); with a level of physical fitness classified as active; participants in a Pro-life program: physical activity and quality of life, attended at NAFEL / UERN	The elderly who had other physical and / or intellectual conditions were excluded from the research process; having celiac disease; elderly people who did not eat orally	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-7t5nqgm	"Effect of occlusal factors on clinical performance in the restorative treatment of cervical lesions
non-carious"	Recruiting	Intervention	2022-11-01	<NULL>	<NULL>	5695	Effects of occlusal factors on the clinical performance of restorations in non-carious cervical lesion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Pontíficia Universidade Católica do Paraná	Pontíficia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7t5nqgm	<NULL>	Good general health; good level of oral hygiene; of age (18 years); having at least two non-carious cervical lesions; presence of occlusal interference; depth of lesions of at least 1mm	Active or chronic periodontitis; bruxism and dental clenching; orthodontic treatment in progress; performance of tooth whitening during the last 6 months; pregnancy and/or lactation; endodontic treatment in the tooth with a non-carious cervical lesion; carious cervical lesion; absence of antagonist tooth in teeth with non-carious cervical lesion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-8nxwps	Effect of Omega-3 in Obese pregnant women on bad pregnancy outcomes	Recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3720	Effect of Omega-3 in Obese pregnant women on unfavorable pregnancy outcomes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade da Região de Joinville - UNIVILLE	Maternidade Darcy Vargas	https://ensaiosclinicos.gov.br/rg/RBR-8nxwps	<NULL>	Pregnant women diagnosed with obesity will be selected according to World Health Organization criteria with a BMI greater than or equal to 30 kg / m2, aged 18 years or over, single pregnancy, with negative screening for gestational diabetes mellitus (GDM) at the beginning of pregnancy, gestational age less than 20 weeks, without pathology that interferes with glucose metabolism, coagulation disorder, systemic arterial hypertension (SAH), history or presence of liver, kidney or gastrointestinal disease or other condition that interferes with absorption, distribution and excretion of omega-3.	Pregnant women who wish to do so and those who are at risk for the fetus will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-7x8tbx	Effect of Omega-3 on Blood Inflammation in Overweight and Liver Fat Patients	Recruitment completed	Intervention	2019-10-01	<NULL>	<NULL>	3017	Mechanism of ômega-3 fatty acids in the inflammatory process via GPR120 in blood cells of Overweight individuals with Non-Alcoholic Fatty Liver Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-05	FCA Unicamp	UNiversidade federal de sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7x8tbx	<NULL>	Patients with excess body weight (body mass index (BMI) greater than or equal to 25.0 kg / m2) between the ages of 19 and 75, of both sexes, diagnosed by the physician of the Hospital Universitário, Universidade Federal de Sergipe, Hepatology Outpatient Clinic with fNon-alcoholic fatty liver disease (NAFLD), as a result of the presence of fat in the liver by ultrasonography, negative serological results for hepatitis B and C, absence of autoimmune diseases, absence of current or previous clinical history of alcohol abuse, absence of other liver diseases caused toxins or metabolites (eg corticosteroids, high doses of estrogen, methotrexate, tetracycline, calcium channel blockers, amiodarone or tamoxifen). The patients should be residents of the Aracaju Metropolitan Region, which is composed by the cities of Aracaju, Nossa Senhora do Socorro, Barra dos Coqueiros and São Cristovão.	Patients pregnant, nursing, allergic to fish and crustaceans, smokers, carriers of diseases that can lead to change in body weight such as hypo or hyperthyroidism, hypogonadism, hyperandrongenism in women, Cushing&apos;s syndrome and other types of secondary obesity, as well chronic kidney disease, cancers and inflammatory bowel disease. Also excluded are individuals taking anti-inflammatory drugs and who in the last three months prior to the study made use of nutritional supplements such as vitamins, minerals, oils and fats or those who are doing some treatment for weight loss and those who have lost more than 10% body weight in the last month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-4xktdc	Effect of Ondansetron on thermal pain levels (heat and cold), mechanical and pain control mechanisms in humans	Data analysis completed	Intervention	2020-03-27	<NULL>	<NULL>	3893	Effect of Ondansetron on the threshold of thermal and mechanical pain and conditioned modulation of pain in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4xktdc	<NULL>	Healthy individuals of both sexes, aged between 18 and 60 years, with classification of physical status by the American Society of Anesthesiologists - ASA I, were invited to participate in the project.	Individuals with chronic pain, defined as pain lasting more than 3 months, of any origin were not included. as well as those who used analgesics, antidepressants, benzodiazepines or any drug with psychoactive action in the last 14 days prior to the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-5qkn8h	Effect of one or two diuretics in patients with decompensated heart failure - a clinical trial	Recruiting	Intervention	2019-07-23	<NULL>	<NULL>	2835	Effect of diuretic combination in patients with acutely decompensated heart failure - a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-09-03	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5qkn8h	<NULL>	Diagnosis of acutely decompensated heart failure; age greater than 18 years; male and female; emergency admission for less than 18 hours; signs of congestion (lower limb edema, pulmonary crackles, chest X-ray with signs of congestion, jugular swelling or hepatojugular reflux, weight gain greater than 4.5 kg); endogenous creatinine clearance greater than 30 ml / min; serum potassium between 3.5 and 5.1 mEq / L; ejection fraction equal to or less than 45% in the last 12 months; to sign a free and informed consent form.	Hypernatremia; Bartter or Gitelman syndrome; renal tubular acidosis type IV; allergy to sulfa; validity of acute coronary syndrome; history of gout; gestation or lactation; septic shock; hepatic dysfunction (elevation of transaminases three times the reference value); inability to enteral intake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-5398927	Effect of online brief intervention to reduce alcohol use during the COVID-19 pandemic: a non-randomized clinical trial	Data analysis completed	Intervention	2023-01-05	<NULL>	<NULL>	5802	Feasibility and effectiveness of brief online interventions to reduce alcohol use among youth and adults during the COVID-19 pandemic: a randomized clinical trial	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-08-05	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5398927	<NULL>	Be 18 years of age or older; both sexes; and agree to participate in all stages of the research	Pregnant women; people with difficulty accessing the internet or mobile phone; incomplete questionnaires; and participants in the pilot study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-10gjt53p	Effect of online Psychotherapy on the quality of life of old people	Not yet recruiting	Intervention	2024-04-26	<NULL>	<NULL>	6971	Effectiveness of online Systemic Relational Psychotherapy for the quality of life of old people: clinical trial randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-10gjt53p	<NULL>	Age between 60 and 80 years old; low quality of life in WHOQOL-bref; mild to moderate depressive symptoms on the GDS-15; access to the internet and digital technologies; live in the northern region of Rio Grande do Sul	Functional and/or cognitive impairment; hearing impairment; in psychotherapy; illiterate; failure to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-9qg9qhh	Effect of oral Probiotic supplementation in children with Obesity: evaluation of the impact on body weight and variables associated with Obesity	Not yet recruiting	Intervention	2023-03-01	<NULL>	<NULL>	5929	Effect of oral Probiotic supplementation in children with Obesity: avaluation of the impact on nutritional status and variables associated with Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-11	Fundação Universidade Federal de São João Del Rei	Secretaria municipal de saúde de Divinópolis	https://ensaiosclinicos.gov.br/rg/RBR-9qg9qhh	<NULL>	Kids; both genders; age between 7 and 10 years; with a nutritional diagnosis of obesity or severe obesity	Children with liver diseases; nephropathy; heart disease; cancer; inflammatory bowel disease using probiotic supplements; prebiotics; symbiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-978gy8	Effect of oral Whey protein and Vitamin C supplementation on markers of nutritional status, inflammation, oxidative stress and quality of life: randomized clinical trial in patients undergoing Hemodialysis	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3760	Effect of oral supplementation of Whey proteins and Ascorbic acid on markers of nutritional status, inflammatory methods, oxidative stress and quality of life: randomized clinical test in Hemodialysis patients	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-978gy8	<NULL>	Be 19 years of age or over; have a diagnosis of CKD; perform HD three times a week in a period of two months and sign the Informed Consent Form	Make use of antioxidants like Vitamin C or E; amino acids; protein or ketoacid supplements, or immunosuppressive drugs within 2 months prior to enrollment or who had an infection or hospitalization in the month prior to the start of the study. Being a carrier of the acquired immunodeficiency virus (HIV); to present a diagnosis of cancer; advanced heart failure, chronic lung disease; liver disease; metal parts in the body like cardiac stimulators, stents, metal dots; have atrophied or amputated limbs; to be hospitalized; being pregnant or breastfeeding; have sequelae that prevent the measurement of parameters and have no ability to understand or communicate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-5xrnrm	Effect of orientation on stress and quality of life of elderly relatives with behavioral changes	Not yet recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3067	Effect of an educational intervention on the emotional or psychological distress and quality of life of family caregivers of elderly with neuropsychiatric symptoms	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-18	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5xrnrm	<NULL>	Inclusion criteria for the elderly to be 60 years of age or older; male or female; with medical diagnosis of Alzheimer&apos;s disease or mixed dementia; classified as mild dementia or moderate dementia; in the outpatient clinic of geriatrics and dementias; presenting one or more neuropsychiatric symptoms and being cared for by a family member. inclusion criteria for the caregiver be the main family caregiver of the elderly selected for the research; reside with the elderly; male or female; aged 18 years or over; reside in the city of Ribeirão Preto; present emotional or psychological erosion and present a preserved cognitive state	Exclusion criteria for the elderly be institutionalized; classified as severe dementia.there is no exclusion criterion for the caregiver	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-10kb7t97	Effect of Osteopathic manipulative treatment on patients who have alterations in the Temporomandibular region and associated Gingivitis	Recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7288	Repercussions of Osteopathic manipulative treatment in patients with Temporomandibular Disorder and associated Gingivitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Escola de Osteopatia de Madrid-Brasil Ltda	Escola de Oteopatia Madrid- Brasil LTDA	https://ensaiosclinicos.gov.br/rg/RBR-10kb7t97	<NULL>	Population of men and women aged 20 to 50; Pain in the Temporomandibular Joint and/or in the masseter, temporal and cervical muscles, with or without biomechanical limitation of the range of motion of the Temporomandibular Joint; Presence of gingivitis, with the following clinical findings: localized (10-30%) or generalized (above 30%) gingival bleeding, depth of up to 3mm, without diagnosed bone loss, with or without edema (CHAPPLE et al., 2018) ; Agree and sign the Informed Consent Form	Have undergone treatment or are undergoing treatment for Temporomandibular Disorder in the last six months; Use of orthodontic appliance; Disclosed depression; Cognitive and neurological changes; Diagnosis of Immune Compromised; Pregnancy; History of surgeries apparently less than a year ago; Smokers; Periodontitis; Use of anxiolytics to treat anxiety; Use of antibiotics for three months; Diagnosis of hiatal hernia; Recent scar, mainly on the abdomen and chest	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-8wd82p8	Effect of Osteopathic treatment for patients with knee Arthrosis	Not yet recruiting	Intervention	2022-11-17	<NULL>	<NULL>	5731	Effects of Visceral Manipulation associated or not with Structural Techniques on pain, range of motion, activation and muscle strength of individuals with knee Osteoarthritis: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto Docusse de Osteopatia e Terapia Manual	Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-8wd82p8	<NULL>	To be included in this study, participants must be over 40 years-old; medical diagnosis of knee osteoarthritis; pain for more than three months; have at least one of the following symptoms: limited range of motion, crepitus, difficulty/pain when going up and down stairs, walking, standing up or sitting in a chair	Exclusion criteria for the present study are history of knee surgery; presence of rheumatoid arthritis; initiation of opioid analgesia or intervention with corticosteroid injection or analgesic for knee pain within the last 30 days; inability to understand and complete study assessments or comply with study instructions; neurological diseases that could influence the investigated outcomes (e.g., stroke)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-289xb7	Effect of Osteopathic Treatment on the Well-Being of Fibromyalgia Patients	Recruiting	Intervention	2020-10-27	<NULL>	<NULL>	4350	Acute effect of Osteopathic Treatment on the Autonomic Nervous System in Fibromyalgia patients	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2020-02-20	Escuela de Osteopatía de Madrid - Brasil	Escuela de Osteopatía de Madrid - Brasil	https://ensaiosclinicos.gov.br/rg/RBR-289xb7	<NULL>	patients must be between 18 and 65 years old regardless of sex; meet the criteria of the American College of Rheumatology with regard to the diagnosis of fibromyalgia;	users of  B-blocking drugs; diagnosed with neurological disease that affects upper motor neuron or progressive conditions; severe osteoporosis; present of fever; infection; malignancy;  inability to answer the questionnaires; physical therapy treatment on the same day of the study; does not reach a score that characterizes the diagnosis as fibromyalgia;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-7rg2tq3	Effect of Osteopathy in individuals with Reflux of stomach contents into the esophagus on quality of life and on the surface temperature of the thoracic region	Recruitment completed	Intervention	2024-07-04	<NULL>	<NULL>	7119	Effect of Osteopathic Treatment in individuals with Gastroesophageal Reflux Disease on quality of life and surface temperature of the thoracic region: preliminary randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7rg2tq3	<NULL>	Diagnosis of Gastroesophageal Reflux Disease (GERD) after medical diagnosis of acid reflux; with upper digestive endoscopy and/or Impedance-pHmetry confirming esophagitis and/or hiatal hernia; or score above 4 on the Health-Related Quality of Life Scale for Gastroesophageal Reflux Disease (GERD-QVRS); age between 18 and 60 years; residents of greater Florianópolis	Previous surgery of the lower esophageal sphincter; peptic ulcer; previous gastric cancer or present cancer; systemic diseases and/or inflammatory symptoms (rheumatoid arthritis; fever; hypertension; fibromyalgia; etc.); neurological or orthopedic diseases that may interfere with the proposed intervention; pregnancy; recent fracture or open wounds; constant use of vasoactive medications; patients who received any treatment using manual techniques	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-86pszd	Effect of Otosporin on the dental sensitivity of bleaching.	Recruitment completed	Intervention	2019-08-16	<NULL>	<NULL>	2879	Effect of Otosporin on dental sensitivity induced by bleaching.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-86pszd	<NULL>	Patients older than 18 years of age. Male and female. With good general and oral health. Teeth free of caries lesions. Have teeth in color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and that they agree with the informed consent term (TCLE).	Will be excluded volunteers who have already undergone dental bleaching. Who have dental prosthesis; previous dental sensitivity; severe dental dimming by pathologies or medications; fixed orthodontic appliance. Who are pregnant or breastfeeding and who are making continuous use of some medicine that reduces the sensitivity dental.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-47v3fh	Effect of overhead respiratory muscle on performance in the six-minute walk test in patients with systolic heart failure	Data analysis completed	Intervention	2016-04-29	<NULL>	<NULL>	824	Effect of respiratory muscle fatigue on performance in the six-minute walk test in outpatients with systolic heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-20	Universidade Federal Fluminense Faculdade de Medicina Hospital Universitário Antônio Pedro	Clínica de Insuficiência Cardíaca Coração Valente Hospital Universitário Antônio Pedro	https://ensaiosclinicos.gov.br/rg/RBR-47v3fh	<NULL>	Patients over 40 years, diagnosed with heart failure with reduced ejection fraction confirmed (Boston criteria), and that part of clinical treatment of heart failure program of the University Hospital Pedro Antonio	Patients with heart rate greater than 120 bpm rest, systolic blood pressure greater than 180 mmHg, diastolic blood pressure greater than 100 mmHg; Malnutrition, as evidenced by a body mass index less than 20 kg / m2; Cold and / or flu in the previous 4 weeks and use of psychotropic drugs, muscle relaxants and immunosuppressants; Inability to walk due to musculoskeletal problems; chest pain previous 4 weeks; cognitive changes that prevent the realization of the Protocol; chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-82qrd2	Effect of overload and relief of air excess in the lungs on exercise capacity in people with Pulmonary Chronic Obstructive Lung Disease	Recruiting	Intervention	2015-03-31	<NULL>	<NULL>	432	Effects of pulmonary hyperinflation on the kinetics of oxygen uptake  in patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-03	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-82qrd2	<NULL>	We will test 21 patients to reach a final eligible 7 patients with Chronic Obstructive Pulmonary Disease stage severe or very-severe and aged 40 to 75 years ; free of exacerbation for at least 2 months; on regular use of prescription drugs; should be able to perform spirometry and exercise testing; both gender; without important comorbidities like other chronic obstructive lung disease or cardiopathy; free of chronic domiciliar oxygen therapy	Patient with  ischemic heart disease ; recent myocardial infarction;  pulmonary arterial hypertension;  uncontrolled systemic hypertension;  diabetes mellitus or  anemia ; furthermore can not participate in the study patients with severe aortic stenosis or  musculoskeletal or rheumatic diseases and  inability to use cycle ergometer for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-2gvk3d	Effect of Oxytocin on Postmenopausal Genital and Urinary Symptoms: Randomized and Double-Blind Study	Recruitment completed	Intervention	2020-03-27	<NULL>	<NULL>	3677	Effect of Oxytocin in Genitourinary Syndrome: Randomized and Double-Blind Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gvk3d	<NULL>	Spontaneous menopause in the last 5 years; any age; denial of the use of hormone therapy in the last 12 months.	History of previous or present malignant disease; previous or present endometrial hyperplasia and an outdated gynecological routine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-76dknt8	Effect of Ozonated Oil as a Desensitizer Prior to In-Office Dental Bleaching – Clinical, Randomized, Blind Study	Recruitment completed	Intervention	2023-11-16	<NULL>	<NULL>	6578	Influence of different Desensitizing Protocols on Sensitivity control after Tooth Bleaching: clinical, blinded and randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-20	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-76dknt8	<NULL>	Patients of both sexes; age between 18 and 35 years; presence of all vital anterior teeth; never bleached or restored; have central incisors of A2 color or darker	Patients with missing anterior teeth; affected by caries lesions; presence of recession; some type of restorative or prosthetic treatment; had a history of dental hypersensitivity; had tooth discoloration by tetracycline or flourose; they used many medications; who fit the status of pregnant or lactating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-95qzc2s	Effect of Ozonated Water on Bad Breath and Clinical Parameters in Patients with Periodontitis	Recruiting	Intervention	2023-01-10	<NULL>	<NULL>	5808	Effect of Ozonized Water on Halitosis and clinical parameters of patients with Periodontal Disease: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Faculdade de Odontologia da Universidade de Passo Fundo	Faculdade de Odontologia da Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-95qzc2s	<NULL>	Complaint of halitosis in the presence of periodontal disease; over 18 years of age; moderate to severe generalized periodontitis	Illiteracy; halitosis only by tongue coating; non-oral halitosis; acute oral lesions or necrotizing ulcerative periodontitis; use of antibiotics in the last 90 days; pregnancy or breastfeeding; decompensated systemic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-8mwt64p	Effect of Ozone Gas on Abdomen Fat	Recruitment completed	Intervention	2025-03-11	<NULL>	<NULL>	7833	Evaluation of the effects of Ozone Therapy in the treatment of Fat Located in the region of abdomen	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-20	Centro Universitário das Faculdades Associadas de Ensino - FAE	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-8mwt64p	<NULL>	Female, aged 18 to 65 years old;  with a body mass index considered eutrophic and/or overweight;  carriers of superficial subcutaneous adipose tissue, such as: localized fat greater than 1.5 cm and cellulite of different degrees; non-smokers;  who agree to participate and sign the TCLE.	"Pregnant women; Patients who have G6PD deficiency;  Age under 18 or over 65; With facial and/or body plastic surgeries in the treatment area; Using home-care dermocosmetics, or other dermatological procedures;  Patients with hemophilia and bleeding disorders;  People with diabetes mellitus and decompensated metabolic disorders; Underwent aesthetic treatment in the treatment region in the last 3 months; Skin lesions, such as dermatitis and dermatoses; Dancerous lesions on or near the area; Participants with a cardiac pacemaker or other implanted electronic device;  Who refuse to sign the free and informed consent form. 
Who miss two consecutive treatments or who start some type of anti-inflammatory treatment or use of dermocosmetics during the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-2dqd733	Effect of ozone gel on pain, swelling and limitation of mouth opening after wisdom tooth extractions in the same patient, one side using the gel and the other not	Not yet recruiting	Intervention	2023-06-26	<NULL>	<NULL>	6176	Effect of ozonized gel on the control of pain, edema and trismus in patients undergoing mandibular third molar extractions: a randomized split-mouth clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-21	Faculdade de Ciências da Saúde da Universidade de Brasília - UnB	Faculdade de Ciências da Saúde da Universidade de Brasília - UnB	https://ensaiosclinicos.gov.br/rg/RBR-2dqd733	<NULL>	Volunteers of both sexes; age between 18 and 30 years; healthy; do not use any medication; having (radiographically evaluated) the two lower third molars in position B and class II of the Pell &amp; Gregory Classification	Volunteer with systemic disease; pregnant; lactating woman; smoker; patient with an infectious process or tumor; person who presents incompatibility with standardized medication; patient who has and wishes to extract upper third molars (provided they are indicated) in the same surgical intervention; patient who wants to extract both lower third molars in the same session	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-78n85q8	Effect of ozone therapy as a complementary treatment for inflamed gums in people with or without diabetes – clinical study	Recruiting	Intervention	2025-05-25	<NULL>	<NULL>	8015	Effect of adjunctive ozone therapy to non-surgical periodontal treatment on clinical, microbiological, and immunological parameters in individuals with periodontitis associated or not with diabetes mellitus type 2 – a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Departamento de Odontologia - Faculdade de Ciências da Saúde - UNB	Departamento de Odontologia - Faculdade de Ciências da Saúde - UNB	https://ensaiosclinicos.gov.br/rg/RBR-78n85q8	<NULL>	Women, men, and all gender identities and sexual orientations. Diagnosis of stage III or IV periodontitis, defined as a chronic multifactorial inflammatory disease associated with a dysbiotic biofilm and characterized by the progressive destruction of the dental attachment apparatus. The diagnostic criteria for stage III or IV include interproximal attachment loss of 5 mm or more at the worst site or radiographic bone loss extending to the middle or apical third of the root, according to the 2018 classification of periodontal and peri-implant diseases and conditions. Presence of at least 10% of sites with bleeding on periodontal probing. Presence of at least two sites with probing depth ≥ 5 mm and bleeding on probing. Diagnosis of type 2 diabetes mellitus, with HbA1c ≥ 6.5%. Treatment for diabetes mellitus with hypoglycemic medications and/or insulin	Periodontal treatment in the last 6 months. Use of antimicrobial and immunomodulatory medications in the last three months. Presence of systemic conditions (other than type 2 diabetes mellitus) that interfere with periodontal status, including HIV, immune disorders, morbid obesity (BMI ≥ 40), or underweight (BMI ≤ 18.5). Pregnant or lactating individuals. Tobacco use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-10mtfw53	Effect of Ozone Therapy in the adjunctive treatment of Periodontitis: randomized, double-blind, split-mouth clinical trial	Recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8602	Ozone Therapy as an adjunct treatment for Periodontitis	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-15	Centro de Ciências Biológicas e da Saúde - CCBS - Universidade Estadual do Oeste do Paraná - UNIOESTE	<NULL>	<NULL>	<NULL>	Age between 25 and 65 years. Both sexes. Presence of at least 12 teeth in the oral cavity, with at least 3 elements per hemiarch (excluding third molars). Diagnosis of Stage II or III Grade A periodontitis (bilateral periodontal pockets with Clinical Attachment Level (CAL) greater than or equal to 5mm)	Completely edentulous individuals. Pregnant and breastfeeding women. Regular use (for 14 days or more) of antibiotics, anti-inflammatories, and immunosuppressants. Wearing fixed orthodontic appliances. Smokers. Presence of systemic alterations. Undergoing treatment for neoplasms	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-10xbwbwg	Effect of Ozonized Water on Wound Healing in the Palate	Recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8393	Effect of Ozonated Water on the Healing of Surgical Palatal Wounds: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-22	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-10xbwbwg	<NULL>	Age between 18 and 60 years; in good general and oral health; present indication for free gingival graft; be undergoing treatment at the special periodontics clinic; have a surgical wound on the palate originating from the free gingival graft donor area; consent to participate in the research	Patients who smoke and/or drink alcohol; patients with systemic alterations that interfere with surgical wound healing (sickle cell anemia, diabetes mellitus); pregnant women; patients who present cognitive and/or neuromotor difficulties that compromise the stages of study development	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-9yy8w2k	Effect of Pain Education associated with Cyclobenzaprine in patients with Masticatory Muscular Pain: a clinical trial	Recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6335	Effect of Neuroscience-based Pain Education associated with Cyclobenzaprine administration in patients with Masticatory Myofascial Pain: a double blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-14	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9yy8w2k	<NULL>	Women; aged 18 to 60 years; diagnosed with muscular temporomandibular disorder or masticatory myofascial pain according to the Diagnostic Criteria for Temporomandibular Disorders; pain greater than or equal to 4 on the Visual Numerical Scale for at least 3 months	History of recent facial trauma within the past 2 years; gestation; continuous use of non-steroidal anti-inflammatory drugs, analgesics, antidepressants or muscle relaxants; intracranial, neurological disorders and other major causes of headache; odontogenic pain; persistent idiopathic dentoalveolar pain; orthodontics; other current treatment for temporomandibular disorders; diagnosis of fibromyalgia; hypersensitivity to cyclobenzaprine or any other component of the product&apos;s formula; any contraindication provided in the package insert for the use of cyclobenzaprine; non-acceptance to voluntarily participate in the research or refusal to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-8cn9qqg	Effect of passion fruit species on human health and the bioavailability of its bioactive compounds	Recruitment completed	Intervention	2023-09-08	<NULL>	<NULL>	6413	Passiflora: interindividual variation in the bioavailability of phenolic compounds and effect on metabolic response	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-29	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8cn9qqg	<NULL>	Nutritional diagnosis of overweight and obesity grade 1 (Body Mass Index - BMI= 25-31 Kg/m2 and 25 to 29.9 Kg/m2); with cholesterol levels above 190 mg/dl; aged between 30 and 55 years; both genders	Previous history of cancer or severe metabolic diseases; digestive system disorders; smoking; allergy to passion fruit and fruit-based products; use of supplementation in the two months prior to the experiment (vitamin C, multivitamin, antioxidant capsules , etc.) or drugs for chronic treatments (antihypertensives, antihyperglycemics, anticholesterol, antidepressants, sleep aids, tranquilizers, etc.); acute treatments in the 15 days prior to the experiment (anti-inflammatories, antibiotics, etc. ); acute treatments in the two days prior to the experiment (inflammatory analgesics such as aspirin, acetaminophen, etc.)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-9jth8n	Effect of passion fruit&apos;s peel flour in the diabetes control	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1075	The effect of passion fruit&apos;s peel flour in glycemic control of people with type diabetes	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-02-18	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Universidade da Integração Internacional da Lusofonia Afro Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-9jth8n	<NULL>	"Being person with type 2 diabetes; between 18 and 65 years old; both sex; no problems in liver or kidney; Not be allergic to passion
fruit."	Being patient with type 1 diabetes; smoker; alcohol drinker; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-5ncdxh	Effect of patient positioning on Nephrolithotripsy results in the treatment of Complex Renal Calculations	Not yet recruiting	Intervention	2018-07-19	<NULL>	<NULL>	2028	Impact of Patient Position on the outcomes of Percutaneous Nephrolithothomy for Complex Kdney Stones	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Hospital de Transplantes Euryclides de Jesus Zerbini	Hospital de Transplantes Euryclides de Jesus Zerbini	https://ensaiosclinicos.gov.br/rg/RBR-5ncdxh	<NULL>	Complex Kidney Stones; Classification Guys 3 or 4; Indication of percutaneous surgery	Contraindication for percutaneous nephrolithotripsy; Ipsilateral or contralateral ureteral calculus; Bladder calculus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-3d9kqb	Effect of peanut in appetite and diabetes risk	data analysis completed	Intervention	2011-06-29	<NULL>	<NULL>	8	Acute and second meal effects of peanuts on glycemic response and appetite in obese women a randomized crossover trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	<NULL>	Universidade Federal de Viçosa	Peanut Collaborative Research Support Program	https://ensaiosclinicos.gov.br/rg/RBR-3d9kqb	<NULL>	Age 18 - 60 years, body mass index  between 30 - 35 kg/m2, not taking medications known to affect glycemia, fat metabolism, or appetite; regular breakfast consumer (?100 kilocalories ingested within 2 hours of waking on ?4d/wk); no body weight fluctuation (&lt;5kg in the past 3 months); willingness to eat all test foods; no self-reported allergy to the foods provided in the study; no self-reported sleep disorders; at least one of the following conditions: waist circumference ? 88 cm; reported family history of type 2 diabetes in first degree relatives; capillary glycemia between 5.5 – 7.0 mmol/L; and/or a 2-hour blood glucose of 7.8 – 11.1 mmol/L (impaired glucose tolerance).	Type 2 diabetes, dyslipidemia or high blood pressure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-6hhmdz	Effect of Pear Orange and Blood Orange Juices on inflammation and antioxidant activity in individuals with pre-diabetes	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3739	Effect of Orange and Blood Orange Juices on the plasma biochemical parametes, functional capacity of monocytes, inflammatory and oxidative stress biomarkers, on individuals diagnosed with insuline resistance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Faculdade de Ciências Farmacêuticas	Fundo de Defesa da Citricultura	https://ensaiosclinicos.gov.br/rg/RBR-6hhmdz	<NULL>	Age between 40 and 60 years, both genders, with nutritional diagnosis of obesity according to the World Health Organization classification (2000) and with diagnosis of insulin resistance according to the HOMA-IR index.	Inflammatory diseases in the gastrointestinal tract, use of supplements or antibiotics and inability to respond to research questionnaires or to perform nutritional status assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-8rrwhfv	Effect of Pelvic Floor Muscle Training using Telephysiotherapy in obese women with reports of urinary loss	Recruiting	Intervention	2021-10-26	<NULL>	<NULL>	5623	Effect of Pelvic Floor Muscle Training using telephysiotherapy  in obese women’s urinary incontinence reports: an assessor blinded randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade de São Paulo	Coordenação de Aperfeiçoamento de pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8rrwhfv	<NULL>	Literate women; older than 18 years; with body mass index (BMI) &gt; 30 kg/m2; who agree on participating on the study through signing the TCLE; who are not in the gestation period and postpartum; self reporting  urinary incontinence in the last four weeks (measured by the score &gt; 0 in the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF); who are not engaged in a weight loss treatment It consists of a questionnaire that was translated and validated to Portuguese by Tamanini et al which evaluates the symptoms, UI severity and the impact that UI has in the woman life quality (QoL). It is a short questionnaire that aims to facilitate the data comparison of different studies and to enable a more consistent and unified evaluation of the UI symptoms and its impact on QoL.	Women who do not want to keep participating in the research; withdrawn their consent to participate  in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3s3ff7	Effect of pelvic floor muscles training on sexual function of postmenopausal women - Randomized controlled trial	Recruitment completed	Intervention	2016-05-30	<NULL>	<NULL>	872	Effect of pelvic floor muscles training on sexual function of postmenopausal women - Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-10-24	Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-3s3ff7	<NULL>	Women Postmenopausal with a maximum of five years of menopause; Women should have the ability to contract the MAP; having sex, which was defined when there is penetration of the penis into the vagina in the past four weeks; women may not submit diabetes; may not submit thyroid diseases; may not present hyperprolactinemia, may not present genital prolapse (above grade 1)	Women who are intolerant (pain, allergy gel or latex condom or other discomfort) the examination of the MAP function; that denying answer the questionnaires in phases that will be applied.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-5ckpd3	Effect of pelvic physiotherapy in women with pain during sexual intercourse	Data analysis completed	Intervention	2017-05-26	<NULL>	<NULL>	1248	Effect of pelvic floor muscle training on the sexual function of women with symptoms of dyspareunia: An experimental study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5ckpd3	<NULL>	Sexually active women who had clinical symptoms of dyspareunia	Those who underwent physiotherapeutic intervention for dyspareunia symptoms recently (less than 6 months); Current symptoms of urinary tract infection; And the presence of diseases that constitute contraindications for the accomplishment of the MAP training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-8k345j	Effect of pentoxifylline use on cardiac function in patients with chagasic cardiomyopathy	Recruitment completed	Intervention	2019-12-13	<NULL>	<NULL>	3287	Effect of prolonged use of Pentoxifylline on myocardial perfusion abnormalities, arrhythmic events and the evolution of left ventricular systolic dysfunction in chronic chagasic cardiomyopathy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-08	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8k345j	<NULL>	The patients will be recruited from the population already attended at the specialized outpatient clinics of the Cardiology Center of the University of Ribeirão Preto Medical School Hospital das Clínicas. The study will include patients with a diagnosis of chronic chagasic heart disease confirmed by two distinct serological tests indirect immunofluorescence and enzyme immunoabsorption assay showing typical left ventricular segmental parietal mobility changes evidenced by transthoracic echocardiography that characterize chronic myocardial involvement by the disease. Study participants should have preserved left ventricular ejection fraction or with a slight reduction greater than 35%, may exhibit mild symptoms of heart failure	Patients with another etiology for myocardial dysfunction such as alcoholism will be excluded, previous myocardial infarction, known coronary artery disease, use of cardiotoxic or illicit drugs and peripartum cardiomyopathy, primary valvular heart disease and pericardial disease. Patients with comorbidities that compromise functional capacity such as severe chronic obstructive pulmonary disease will also be excluded; severe liver disease; collagenosis, untreated thyroid dysfunction. Coronary artery disease should be excluded by cardiac catheterization in those patients with ischemic perfusion defects on myocardial perfusion scintigraphy who exhibit 2 or more risk factors for atherosclerotic coronary artery disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-93qpgnf	Effect of pequi oil supplementation combined with physical exercise on body composition and blood pressure	Recruiting	Intervention	2021-02-03	<NULL>	<NULL>	4501	Effect of pequi oil supplementation on body composition and hemodynamic variables after aerobic and anaerobic exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Centro Universitário de Brasília - UniCEUB	Instituto Federal de Educação, Ciência e Tecnologia de Brasília, IFB	https://ensaiosclinicos.gov.br/rg/RBR-93qpgnf	<NULL>	Be between 20 and 49 years old. Have experience in Strength Training or aerobic training in a period between 1 and 8 months. Do not have any type of joint or muscle injury that could compromise the performance of the exercises. Sign the TCLE and agree to be part of the intervention.	Have some physical and intellectual limitations that prevent testing. Presenting musculoskeletal diseases that contraindicate the practice of Strength/aerobic Training. Presenting uncontrolled cardiovascular, nutritional, metabolic or endocrine disorder that is known to affect the muscular system, such as hypo or hyperthyroidism and type 2 diabetes. To use antioxidant/ant-inflammatory supplements; Smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-892mp4	Effect of perineal exercises to prevent recurrence of vulvar discharge and improve female sexuality	Terminated	Intervention	2016-01-18	<NULL>	<NULL>	685	"Effectiveness of therapeutic exercise applied to the pelvic floor muscles to prevent recurrence of Vulvovaginitis and improve female sexuality:
randomizad clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Estadual de Campinas - Unicamp	Universidade Estadual de Campinas - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-892mp4	<NULL>	Women will be included among 18 and 45; sexually active; have recurrent candidiases (RVVC) or bacterial vaginoses (RBV); be willing to participate in therapy sessions urogynecological and accept; voluntarily sign the free and informed consent form (TCLE)	"Women will be excluded: menopausal; pregnant, in prophylactic treatment for RVVC or RVB; with
Symptoms of urinary and/or fecal incontinence; prolapse 2 and 3 have pelvic organ; vaginal stenosis and complaining of chronic pelvic pain have psychiatric disorders; restriction
musculoskeletal; neoplastic disease and/or chronic degenerative diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-103674zd	Effect of periodontal dressing on healing of gum removal procedure	Recruiting	Intervention	2023-05-07	<NULL>	<NULL>	6057	Effect of periodontal dressing on gingivectomy healing	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-103674zd	<NULL>	18 years or older; In good general and oral health; Present indication for gingivectomy/gingivoplasty in the anterior region; Consent to participate in the research	Patients who smoke; patients who consume drink alcohol; Use fixed orthodontic appliance; Frequent use of phenytoin, nifedipine or cyclosporine; Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-2vjvxv	Effect of Periodontal Therapy in association with Probiotic in the microbial communities of the mouth and intestine.	Recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2287	Impact of Nonsurgical Periodontal Therapy in association with Probiotic in the intestinal and oral microbiome: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-10-08	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	Instituto de Microbiologia Paulo Góes da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2vjvxv	<NULL>	Subjects with eighteen years or more; who have at least fourteen natural teeth, excluding third molars; and advanced chronic periodontitis which is determined as pocket probing depth equal or greater than six mm in three or more periodontal sites and bleeding on probing in twenty percent of the sites examined.	"Exclusion criteria are the need for antibiotic prophylaxis; having received antibiotics therapy in the three-month period prior to the study; having received periodontal therapy in the six-month period prior to the study; chronic gastrointestinal diseases or abnormalities of the gastrointestinal tract; metabolic disorders; cardiovascular diseases; immunological disorders; HIV infection; be a smoker or have stopped smoking in less than 
five years; ongoing orthodontic treatment; have Body Mass Index  equal or greater than twenty-five; be pregnant or breastfeeding, if woman."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-69yzkb	Effect of periodontal treatment on blood vessels and inflammation in type 2 diabetics with gum disease	Recruiting	Intervention	2015-02-19	<NULL>	<NULL>	396	Effect of periodontal treatment on endothelial and microvascular functions and gingival fluid and blood levels of immunoinflammatory biomarkers in type 2 diabetics with severe periodontitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-11	Hospital Universitário Pedro Ernesto	Faculdade de Odontologia da UERJ	https://ensaiosclinicos.gov.br/rg/RBR-69yzkb	<NULL>	Patients with severe periodontitis; both genders; more than 18 years old; at least 12 teeth; type 2 diabetes mellitus	HIV; immunological and chronic inflammatory diseases; prolonged usage of medications 6 months before the start of the study as antibiotics; cortisone; antihistamine; hormones; and others	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-2qz78q	Effect of periodontal treatment on pcr and psa in patients with prostate cancer and periodontitis	Recruiting	Intervention	2019-08-14	<NULL>	<NULL>	2871	Effect of basic periodontal therapy of cpr and psa circulating levels in patients with prostate Cancer and Periodontitis	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-08	Luiza Silveira Camilotto	Luiza Silveira Camilotto	https://ensaiosclinicos.gov.br/rg/RBR-2qz78q	<NULL>	Male; age minimun 21 years; definitive diagnosis of prostate cancer determined by prostatic biopsy, performed preferably guided by transrectal ultrasonography; no professional dental prophylaxis performed in the last 3 months; minimun 06 teeth present; able and willing to understand the protocol and sign a consent form.	Positive history of periodontal treatment in the last six months; diabetes; history of myocardial infarction, stroke, or organ transplantation during the last 6 months; the need for antibiotic prophylaxis to perform routine dental procedures; use of anti-inflammatories for a long period of time, or any medicine that may interfere with periodontal aspects; smoking; patients who were unable to attend the appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-565p4b	Effect of perioperative venous lidocaine on postoperative ileus time and hospital discharge after bariatric surgery by Laparoscopic	Recruitment completed	Intervention	2019-02-15	<NULL>	<NULL>	2482	Evaluation of the effect of perioperative venous Lidocaine on the return time of intestinal function and the length of hospital stay after Laparoscopic Gastroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal de São Paulo	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-565p4b	<NULL>	age above 18 years; obesity grade 2 or 3; under 65 years	BMI below 35; BMI above 50; children under 18; age over 65 years; allergic to lidocaine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-8494rf7	Effect of Pharmaceutical Care on patients with Chronic Pain	Recruiting	Intervention	2024-08-08	<NULL>	<NULL>	7192	Effect of Pharmaceutical Care on patients with Chronic Pain: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-25	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8494rf7	<NULL>	Patients previously diagnosed with rheumatoid arthritis and/or fibromyalgia, according to the diagnostic criteria of the American College of Rheumatology. Patients of both gender. Aged over 18 years. Who have been using pharmacotherapy prescribed for rheumatoid arthritis for at least 6 months, and/or pharmacotherapy prescribed for fibromyalgia for at least 1 month	Patients with severe psychiatric disorders; cancer; pregnant women; those participating in other clinical trials that have the same outcomes or interventions that may cause a risk of bias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3qc35b	Effect of phone call made by nurses on elderly people with demencia and their caregivers	Recruitment completed	Intervention	2020-06-23	<NULL>	<NULL>	3937	Effect of telecare on elderly people with dementia and their caregiver	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-11	Universidade Federal Fluminense	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-3qc35b	<NULL>	Elderly: having a dementia diagnosis; Have primary caregiver; Be accompanied by the dementia service in University Hospital in Brasilia;  Be aged 65 and over, Mini Mental State Examination - MMSE less than or equal to 26. Caregiver: caregiver is available for orientation; to have cognitive capacity of answer oriented in the time and space for this interface with the researcher and to accept to participate of the research.	Elderly: possess clinical instabilities such as oxygen balloon, decompensated Congestive Heart Failure, cancer, congestive obstructive pulmonary disease, cardiovascular diseases, cerebrovascular diseases, psychiatric diseases, and advanced palliative care. Caregivers: hearing impaired caregivers who limit communication by phone and video call; and caregiver with untreated psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-10nyxwkr	Effect of Photobiomodulation and Enamel-Derived Matrix Proteins on Bone Repair in Maxillary Sinuses grafted with Deproteinized Bovine Bone	Recruiting	Intervention	2023-10-19	<NULL>	<NULL>	6685	Effect of Photobiomodulation and Enamel-Derived Matrix Proteins on Bone Repair in Maxillary Sinuses grafted with Deproteinized Bovine Bone - A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10nyxwkr	<NULL>	The patient required to present between 18 and 60 years old. need unilateral or bilateral elevation of the floor of the maxillary sinus for subsequent installation of osseointegrated implants. present bone availability associated with the alveolar ridge adjacent to the maxillary sinus less than or equal to 3mm. present good systemic health. present at least less than 4 months of healing of the socket after tooth extraction	Smokers. decompensated diabetics. patients with chronic or aggressive periodontitis. patients who use drugs that alter bone metabolism. patients who have chronic infections of the upper airways. patients who chronically use anti-inflammatory drugs and antibiotics. people with bruxism. alcoholics. drug addicts. pregnant women or who wish to become pregnant in the next year. history of radiotherapy treatment in the head and neck region. patients with pathologies that affect bone metabolism. patients who have had a major disruption of the sinus membrane during surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-10m474jv	Effect of photobiomodulation application on neck muscle pain	Not yet recruiting	Intervention	2022-07-18	<NULL>	<NULL>	5492	Effect of photobiomodulation on trapezius myofascial pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-15	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-10m474jv	<NULL>	Men or women aged 18 or over; diagnosis of trigger point in the upper trapezius muscle by the diagnostic criteria according to the consensus described in the study by Fernandez-De-Las-Penas and Dommerholt (2018), in which three criteria are established: two manual findings (a tense band and a hypersensitive point) and a symptom (referred pain, with characteristic depth and irradiation), requiring the presence of one of the manual findings and referred pain for the diagnosis to be positive.	neck or shoulder trauma; diseases that contraindicate the use of laser; surgery history; refusal to perform the assessment and intervention after randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-9ztp7q7	Effect of Photobiomodulation on tissue healing in Palatal Graft Donor Areas	Recruitment completed	Intervention	2022-11-16	<NULL>	<NULL>	6743	Effect of Dual-Wavelength Photobiomodulation on tissue healing of Connective Tissue Graft Donor Areas	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9ztp7q7	<NULL>	Necessity for periodontal surgery for root coverage with the need for a connective tissue graft; lack of previous experience with wound treatment in soft tissue graft donor regions; ability to maintain good oral hygiene; being systemically healthy or have systemic diseases compensated; being between 18 and 60 years old; both genders	History of untreated periodontal disease; smoking patients, lack of availability of a subepithelial or free gingival connective tissue graft donor bed; hypersensitivity to any anesthetic; medication or antiseptic product used in surgery; medical limitation for elective surgical procedures; patients undergoing orthodontic treatment and pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-899fry6	Effect of photodynamic therapy on gum treatment in patients with Down Syndrome	Recruiting	Intervention	2023-12-08	<NULL>	<NULL>	6641	Evaluation of Antimicrobial Photodynamic Therapy as an adjunctive therapy to the treatment of Periodontitis in individuals with Down Syndrome: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Faculdade de Odontologia de Araçatuba FOA	Faculdade de Odontologia de Araçatuba FOA	https://ensaiosclinicos.gov.br/rg/RBR-899fry6	<NULL>	Patients with diagnosis of periodontitis stages III and IV grade C according to the new classification with interproximal clinical attachment level (CAL) ≥ 2 or ≥ 3 mm in more than 2 non-adjacent teeth; Patients of both sexes; Who had not received periodontal treatment within 3 months with at least 2 sites with probing depth (PD) ≥ 4mm and a minimum of 15 teeth present in the oral cavity, excluding third molars	Smokers or ex-smokers for more than 5 years; Patients with anemia; Patients with active cancer and history of chemotherapy; History of antibiotic therapy in the previous 3 months; History of anti-inflammatory therapy in the last 3 months; Patient with blood disorders; Patient undergoing orthodontic treatment; Patients who required prophylactic antibiotic therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-96bkkj7	Effect of photon electromagnetic device in patients with neck pain	Recruitment completed	Intervention	2023-08-29	<NULL>	<NULL>	6399	Effect of Bioelectromagnetism and Photontherapy in patients with cervico- brachial neuralgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-96bkkj7	<NULL>	Adult individuals; age between 18 and 65 years; both genders; report neck pain equal to 4 or more on the VAS scale.	"Individuals with pain less than 4 on the VAS; pregnant women; cardiac pacemakers and other electronic implants; post-traumatic neck pain; patients with visual and hearing disorders; sleep, cognition and emotion disorders and individuals who used analgesics, muscle relaxants and anti-inflammatory drugs in the last 12 hours.
painkillers, muscle relaxants and anti-inflammatory drugs in the last 12 hours."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-7sxygc	Effect of Physical Activity and blood glucose after meal in people with Diabetes	Recruitment completed	Intervention	2019-10-08	<NULL>	<NULL>	3048	Effect of Physical Activity on postprandial blood glucose in individuals with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal do Ceará	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7sxygc	<NULL>	Both sexes, age between 40 and 80 years, clinical diagnosis of diabetes mellitus type, pharmacological plan unchanged in the last eight weeks	Fasting glycemia greater than 250 mg / dl, insulin treatment, body mass index greater than 39.9 kg / m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-3wn6tf	Effect of physical and mental training, involving two tasks together, on the functionality of the elderly	Not yet recruiting	Intervention	2018-05-31	<NULL>	<NULL>	1862	Efect of motor-cognitive training (double task) in the functionality of elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal Do Triângulo Mineiro	Universidade Federal Do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-3wn6tf	<NULL>	Minimum score of 18 points in the Mini-Mental State Examination (MMSE); be literate; presenting visual acuity preserved or corrected	"Inability to maintain orthostatism and to wander without the use of any auxiliary gait device; those who are submitted to another type of physiotherapeutic intervention concomitantly; participants during the study period: changes such as significant or chronic orthopedic pain, joint deformities,
three consecutive service sessions, any of the non-inclusion characteristics already mentioned"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-7jq63n	Effect of physical conditioning in patients with spinal cord injury to improve physical endurance.	data analysis completed	Intervention	2012-01-26	<NULL>	<NULL>	64	Effectiveness of aerobic physical training for prevention and treatment of chronic asymptomatic bacteriuria in subjects with spinal cord injury: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7jq63n	<NULL>	Subjects with spinal cord injury between C5 and L2 segments according to the classification of American Spinal Injury Association (ASIA).	individual practitioner of regular physical activity, community ambulators, unable to ride the cycle ergometer with the arms and those who refuse signing the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-5tmjnd	Effect of physical conditioning in patients with spinal cord injury to increase physical resistance.	data analysis completed	Intervention	2012-01-31	<NULL>	<NULL>	71	Effectiveness of aerobic physical training applied to patients with spinal cord injury to increase oxygen consumption.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-5tmjnd	<NULL>	Individuals with SCI between segments C5 and L2 according to the classification of the American Spinal Injury Association	Individuals who do regular physical activity, community ambulators and individuals who were unable to pedal the cycle ergometer with their arms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-4r6p5v	Effect of physical exercise and nutritional programs on the health status of schoolchildren aged 4 to 11 years old from Santo Antônio de Goiás	Recruitment completed	Intervention	2018-07-06	<NULL>	<NULL>	1969	Metabolic syndrome: metabolic, oxidative and inflammatory responses of physical exercise and nutritional programs in schoolchildren aged 4 to 11 years old from Santo Antônio de Goiás	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-02	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4r6p5v	<NULL>	Be aged between 4 and 11 years old; both genders; to reside in Santo Antônio de Goiás; to be enrolled in the city elementary school.	Have cognitive or physical disabilities; have pathologies such as respiratory, cardiologic, renal or hepatic chronic diseases, which prevent data collection and vitamin D supplementation; being in use of any medication that influences the serum concentration of lipoproteins; have used cholecalciferol supplement in the last 10 weeks; serum 25-hydroxyvitamin D levels above 75 ng/dL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-34khhv	Effect of Physical Exercise and Respiratory Therapy After Cardiac Surgery	Recruiting	Intervention	2013-09-19	<NULL>	<NULL>	251	Impact of Physical Exercise Associated to CPAP Application on Coronary Artery Bypass Grafting Surgery Postoperative	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-09-12	Universidade Federal de São Carlos	Irmandade da Santa Casa de Misericórdia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-34khhv	<NULL>	Volunteers with clinical diagnosis of coronary artery disease by coronary angiography and absence of acute or chronic lung disease, undergoing elective coronary artery bypass grafting surgery with cardiopulmonary bypass, median sternotomy incision type and interposition of saphenous vein graft, or internal mammary artery or radial.	Not perform the surgical procedure according to the technique already specified, reoperations and / or associated procedures like approach valvular or carotid endarterectomy, present malignant ventricular arrhythmias, complexes ventricular premature beats, supraventricular tachycardia or sinus greater than 120 beats per minute, atrioventricular block of 2nd or 3rd degree, signs of low cardiac output or ventricular failure, hypotension, heart failure and recent myocardial infarction (less than 6 months), present chronic obstructive pulmonary disease, diabetes mellitus with documented diabetic neuropathy and/or presence of disease in the kidneys and liver, users of heart pacemaker, general impairment, weakness, fever, and associated neurological sequelae and difficulty understanding and/or adherence to study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-7g4dhr	Effect of physical exercise for the muscles of respiration in the body&apos;s defense system in the elderly	Data analysis completed	Intervention	2019-03-28	<NULL>	<NULL>	2558	Effect of Respiratory Muscle Training on the Immune Response in the elderly	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação de Amparo a Ciência e Tecnologia de Pernambuco	Fundação de Amparo a Ciência e Tecnologia de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7g4dhr	<NULL>	Adults older than 65 years of age; of both sexes; who lived in healthy nursing homes and who agreed to participate in the study by signing the ICF.	Elderly patients who did not understand some of the steps of the proposed protocols; with a body mass index above 35 mL / kg²; or with some degree of orthopedic or neurological limitation that made the tests impossible were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-9wwp8kp	Effect of Physical Exercise in older adults with Pulmonary Disease from Manizales	Data analysis completed	Intervention	2023-03-22	<NULL>	<NULL>	5955	Effect of Physical Training Intervention on the muscular function of elderly adults with Chronic Obstructive Pulmonary Disease from Manizales	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Universidad Autónoma de Manizales	Alcaldía de Manizales	https://ensaiosclinicos.gov.br/rg/RBR-9wwp8kp	<NULL>	Residents of Manizales, Colombia; aged over 50 years; diagnosis of Chronic obstructive pulmonary disease (COPD) (GOLD I-IV) confirmed by spirometry; evidence of a Forced Expiratory Volume in the first second (FEV1) / Forced Vital Capacity (FVC) ratio less than 70	Diagnosis of known respiratory disorders other than Chronic Obstructive Pulmonary Disease (COPD); history of significant inflammatory disease; malignancy; coronary disease; carrier of osteosynthetic material; partial or total limb amputation; neuromuscular, orthopedic and/or medical disease that impedes or physical exercise; CPOD exacerbation in the four weeks prior to inclusion; recent surgery and participation in pulmonary rehabilitation programs or physical exercises in the last year	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-3q52x4	Effect of physical exercise in the context of depression and its respective factors in obese individuals	Recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2505	Effect of physical exercise in the context of depression and its respective factors in obese individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Jeronimo Costa Branco	Universidade Franciscana - UFN	https://ensaiosclinicos.gov.br/rg/RBR-3q52x4	<NULL>	The individual must be linked to one of the 14 ESF of the municipality of Santa Maria-RS; To present the Body Mass Index that classifies it as obese (BMI = weight / height2) equal to or greater than 30 kg / m2; Present indicative of depression to make up the group of depressed obese; Be between 18 and 60 years of age; Not performing physical activity (self reported) in the last 3 months. Not being on antidepressant medication at the start of the study	Those individuals who present a medical contraindication for the performance of physical activity in the soil and / or water	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-4jm343	Effect of Physical Exercise on blood levels of fat and Inflammation of young women using Contraceptives	Data analysis completed	Intervention	2019-12-11	<NULL>	<NULL>	3831	Effect of Physical Exercise on the lipid and inflammatory profiles of young women in continuous Oral Contraceptive use	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-10	Grupo Nobre de Ensino Ltda.	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-4jm343	<NULL>	Sedentary women; nulliparous; continued use of combined oral contraceptives for 6 months or more, aged 20 to 30 years.	Hepatic Impairment; diabetes; thyroid dysfunctions; kidney diseases; use of anabolics; alcoholism; smoking; corticoids; use of lipid lowering agents; diuretics; beta-blockers; obesity; polycystic ovary syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-75yrff5	Effect of Physical Exercise on blood, functional and neurological variables of elderly people with Alzheimer&apos;s Disease	Recruiting	Intervention	2023-05-15	<NULL>	<NULL>	6076	Effect of Multicomponent Training on biochemical, neuropsychiatric, cognitive, functional, and physiological aspects in elderly with Alzheimer&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Programa de Pós-graduação em Ciências da Saúde	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-75yrff5	<NULL>	Elderly aged 65 years or older diagnosed with Alzheimer&apos;s	Participants who did not attend at least 70% of the training protocol classes; participants who, during the training, are not in the conditions provided for in the criteria; participants who drop out; present osteoarticular, musculoskeletal, cardiovascular, visual, auditory complications or impairment, vertigo syndrome or other limitations that hinder locomotion, performance of tests and intervention; having other neurodegenerative diseases concomitantly with Alzheimer&apos;s disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-9xhn6qn	Effect of physical exercise on functional capacity, muscle strength and quality of life in patients with liver cirrhosis	Not yet recruiting	Intervention	2024-05-10	<NULL>	<NULL>	6999	Effect of physical exercise program on functional capacity, peripheral muscle strength, respiratory muscle strength and quality of life in patients diagnosed with liver cirrhosis: randomized controlled experiment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-9xhn6qn	<NULL>	Patients diagnosed with liver cirrhosis with Child A classification; both sexes; minimum age of 18 years and undergoing clinical monitoring	volunteers with encephalopathy from grade 2 (through clinical diagnosis); who had esophageal varices in the last 6 months (through clinical diagnosis); volunteers who have respiratory pathologies and/or associated musculoskeletal pathologies (through medical diagnosis prior to the research); and exercisers for at least 3 months (self-report)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-2qkx69	Effect of physical exercise on functionality and molecular markers in institutionalized elderly	Recruitment completed	Intervention	2020-03-03	<NULL>	<NULL>	3551	"Effect of Physical Exercise on Clinical Functional outcomes
and modulation of Epigenetic Markers in institutionalized elderly"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-2qkx69	<NULL>	"age over 60 and have
ability to walk without bracing"	"Make use of medicines containing HDAC inhibitor such as Acid
Valproic, have other associated neurological diseases, problems
orthopedic and / or musculoskeletal disorders that affect gait, cognitive impairment
Mini Mental State Examination (MMSE), inability to
communicate with investigators or have no medical clearance to perform
physical activity"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-9phj2q	Effect of physical exercise on motor parameters and blood markers in post-stroke patients	Recruitment completed	Intervention	2019-02-11	<NULL>	<NULL>	2474	Effect of physical exercise on clinical-functional outcomes, modulation of epigenetic markers and levels of brain-derived neutrotrophic factor (BDNF) in peripheral blood in post-stroke patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Centro Universitário Metodista-IPA	Centro Universitário Metodista-IPA	https://ensaiosclinicos.gov.br/rg/RBR-9phj2q	<NULL>	Inclusion criteria adopted will be stroke for at least 6 months; be over 59 years old and have the ability to walk without using a bracing.	Individuals will be excluded if they use drugs containing HDAC inhibitors; such as Valproic Acid; other associated neurological diseases; orthopedic and / or musculoskeletal problems affecting gait; cognitive impairment identified by the Mini Mental State Examination (MMSE); disability the risk of deep venous thrombosis; have sensory deficits in the hemiparetic limb; cardiac pacemaker patients; pregnant women and individuals with metal plaques and cancer in the region of the fibula head (site that will be stimulated by FES).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-2stdy4v	Effect of physical exercise on postural control and locomotor performance in people with hemophilia	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7657	Effect of physical exercise, functional capacity, postural control and kinematic analysis of locomotor performance during obstacle overcoming associated with gripping movement in people with hemophilia	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo - Campus Goiabeira	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-2stdy4v	<NULL>	Volunteers with Hemophilia A or B; Mild to Moderate or Severe Projects; male; body mass index less than 30	History of hip; knee; and ankle surgery; inability to walk with or without a device such as a cane or walker; history of bleeding into muscles or joints in the past 2 months; respiratory or neurological disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-5cc79w	Effect of physical exercise on strength, muscle mass,  movement, functional capacity and inflammation in sarcopenic and non sarcopenic elderly	Recruiting	Intervention	2016-08-12	<NULL>	<NULL>	957	Effect of resistance training in muscle strength, muscle mass, mobility, functional capacity and biochemicals parameters in sarcopenic and non sarcopenic elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista	Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5cc79w	<NULL>	Individuals must be aged 60 or over; both genders; be clinically stable.	Inability to get around; being bedridden; musculoskeletal dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-887gqvs	Effect of physical exercise on the condition of how much the heart and lung function, about tiredness and quality of life in cancer patients who underwent bone marrow transplantation in up to 100 days	Recruiting	Intervention	2021-09-08	<NULL>	<NULL>	4865	Effect of physical exercise on cardiac, pulmonary, muscular capacity, fatigue, quality of life and exercise level in cancer patients who underwent bone marrow transplantation within 100 days	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-07	Universidade do Estado de Santa Catarina	Centro de Pesquisas Oncológicas - CEPON	https://ensaiosclinicos.gov.br/rg/RBR-887gqvs	<NULL>	Be under oncohematological treatment during the hospital stay; Have authorization from the doctor and the responsible team to participate in the study; Both sexes; Present a diagnosis of leukemia, myelodysplastic syndromes and lymphomas; Age from 18 years old.	Present any complications, such as bleeding, acute respiratory failure, congestive heart failure and, among others, patients that pose a risk in the development of the oncohematological treatment; Patient in isolation with infectious or contagious or hemodynamically unstable disease, such as the use of vasoactive drugs, blood pressure instability, high-response atrial fibrillation and others; Have orthopedic, degenerative and / or amputation limitations and anemia (Hb &lt;8); Thrombocytopenic patients with platelet values below 10,000 / m³.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-10yxgcr9	Effect of physical exercise performed at home on people with the indeterminate form of Chagas disease	Not yet recruiting	Intervention	2021-01-12	<NULL>	<NULL>	5873	Home-based physical exercise program in the indeterminate form of Chagas Disease (PEDI-CHAGAS STUDY): A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz	Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-10yxgcr9	<NULL>	Serological positivity for Chagas disease; both sexes; absence of symptoms and or clinical signs of cardiac and / or digestive disorders associated with Chagas disease.	Age below 18 years; cardiopathies of non-chagasic etiology; osteomioarticular changes that make it impossible to perform the physical exercise protocol; clinical contraindication for physical exercise; regular physical exercise in the last 2 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-7tmgb9b	Effect of Physical Exercise training on the level of body function, intensity of Back Pain, Depressive Symptoms and Ability to Breathe in Chronic Kidney Patients undergoing hemodialysis	Recruitment completed	Intervention	2025-06-03	<NULL>	<NULL>	8031	Effectiveness of Physical Exercise training on the level of functionality, intensity of Low Back Pain, Depressive Symptoms and Respiratory Capacity in Chronic Kidney Patients undergoing hemodialysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Faculdade Ciências Médicas de Minas Gerais	Faculdade Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7tmgb9b	<NULL>	Patients with Chronic Kidney Disease - CKD in stages 4 and 5 (Classification of the Brazilian Society of Nephrology), aged 18 years or older; both sexes;  who have been undergoing Hemodialysis - HD for more than three months and three times a week	Resistant and uncooperative patients, who do not have the cognitive conditions to respond to questionnaires and carry out assessments based on the criteria and cut-off points proposed by the Mini Mental State Examination (MMSE) and according to education; who present an unstable clinical condition; neurological diseases; and patients who complete 60% or less of the exercise protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-5dmpkr	Effect of physical therapy in the diaphragm of the elderly on the function of the lungs	recruitment completed	Intervention	2012-05-10	<NULL>	<NULL>	133	Study of the transcutaneous electrical diaphragmatic muscle stimulation.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5dmpkr	<NULL>	"Male volunteers;
Aged between 67 and 79 years;
Not practicing physical exercises regularly."	"Elderly Smokers;
History of pulmonary disease, neuromuscular disorders and postural muscles that affect the respiratory or cardiovascular diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-2hxj58	Effect of physical therapy in the treatment of knee osteoarthritis	Data analysis completed	Intervention	2015-08-18	<NULL>	<NULL>	594	Effects of different physical therapy protocols on knee osteoarthritis treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-12	UNESP - Faculdade de Medicina de Botucatu	FAI - Faculdades Adamantinenses Integradas	https://ensaiosclinicos.gov.br/rg/RBR-2hxj58	<NULL>	Aged 60 and over; both sexes; diagnosis of OA in one knee and the functional class I, II and III according to clinical and radiographic criteria of the American College of Rheumatology	Associated disease that primarily affects the lower limbs (ankylosing spondylitis; rheumatoid arthritis; neurological diseases); surgical history on his knees in the last year; physical therapy the past six weeks; contraindications to the aquatic and terrestrial service; osteoarthritis functional class IV according to clinical and radiographic criteria of the American College of Rheumatology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-34dc8f4	Effect of physical training associated or not with Whole-Body Electromyostimulation at elderly people survivors of COVID-19	Not yet recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6910	Effect of physical training associated or not with Whole-Body Electromyostimulation in Functional, Vascular and Autonomic variables of elderly people survivors of COVID-19: controlled clinical trial and randomized	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2024-06-17	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-34dc8f4	<NULL>	Elderly people of both sexes; aged over 60 years; positive diagnosis for COVID 19 according to the test at least 2 months before being included in the exercise protocol; classified with Post COVID 19 Functional Status Scale greater than 2; volunteers who tested positive for COVID 19 and were isolated at home; as per WHO guidance; elderly people who required hospitalization due to COVID 19 after 30 days of hospital discharge as previously recommended and who present post COVID 19 syndrome; patients with persistent symptoms of fatigue and dyspnea within 1 to 3 months after confirmed diagnosis of COVID 19	Volunteers with orthopedic or neurological impairments that prevent participation in a physical exercise program; myocardial infarction; within six months of the beginning of the study; implanted pacemaker or any metallic synthesis; history of heart disease; unstable angina; arterial hypertension controlled; uncontrolled or insulin dependent diabetes mellitus and participation in a regular physical exercise program at the beginning of the study; hospital admission less than 72 hours ago; volunteers will also be excluded if they present hypersensitivity to electrical stimulation; chronic obstructive pulmonary disease;heart failure; asthma; previous tuberculosis; bronchitis; lung cancer; a condition that may compromise the performance of functional tests, documented diabetic neuropathy; cognitive deficit; difficulty understanding or adherence to study procedures; declared users of illicit drugs; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-5xt9pw	Effect of physical training exercises performed at home with the help of videoaula in renal patients	Recruitment completed	Intervention	2013-12-09	<NULL>	<NULL>	268	Effect of physical training home associated with the use of technology in patients with end stage renal disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-01	Universidade de Passo Fundo	Paulo Ricardo Moreira (Coord. da pesquisa no Hospital São Vicente de Paulo)	https://ensaiosclinicos.gov.br/rg/RBR-5xt9pw	<NULL>	Individuals aged 18 years or more; of both sexes; diagnosed with CRF and on kidney dialysis, who are not performing exercises frequently, having dvd player at home.	Patients unable to take exercise, without cognitive capacity, which prevents the understanding and implementation of the proposed exercises, which are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-5t8dbp	Effect of Physical Training in Treadmills on stiffness of arteries of Diabetic patients	Not yet recruiting	Intervention	2018-08-27	<NULL>	<NULL>	2153	Effect of Aerobic Training based on maximal fat oxidation on arterial stiffness in subjects diagnosed with Diabetes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Programa de Pós-Graduação em Fisioterapia - PPGFt	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5t8dbp	<NULL>	Individuals diagnosed with type 2 diabetes of both sexes; from 40 to 60 years of age; who do not exercise vigorously at maximal and frequency greater than or equal to three times a week and who agree to participate in the study and sign the term of free and informed consent.	Individuals with a history of clinically proven cardiopathy or examination; uncontrolled arterial hypertension; musculoskeletal or respiratory disorders; cognitive disturbances that prevent the understanding of the experimental procedure; pregnant women; smokers; alcoholics or users of non-licit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-6zpc65f	Effect of Physical Training on cardiovascular parameters, quality of life and sleep in the elderly	Recruiting	Intervention	2023-02-14	<NULL>	<NULL>	5905	Effect of a Functional Training Program on echocardiographic, hemodynamic, functional parameters, quality of life and sleep in the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-20	Universidade Federal da Paraiba	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-6zpc65f	<NULL>	Volunteers of both genders; 60 years of age or older; arterial hypertension in stages I and II; body mass index less than 34.9 kg/m2	Smoking volunteers; morbid obesity; respiratory and heart disease; peripheral arterial disease; musculoskeletal diseases that make it impossible to practice physical exercise; participate in another physical training protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-84zdp6	Effect of physiotherapeutical treatment on hip pain in women	Not yet recruiting	Intervention	2018-05-15	<NULL>	<NULL>	1795	Randomized clinical trial: The effect of a physiotherapy protocol in Greater trochanteric pain syndrome in women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Estadual Paulista, Faculdade de Filosofia e Ciências	Universidade Estadual Paulista, Instituto de Biociências	https://ensaiosclinicos.gov.br/rg/RBR-84zdp6	<NULL>	Clinical diagnosis of major trochanter pain syndrome, chronic lateral pain in the hip greater than or equal to 3 months, presenting pain (4/10) in the visual analogue scale, tenderness in the trochanter region (4/10), pain during daily activities, pain in at least 1 of the 7 provocative clinical tests of pain, which is intended to transmit compressive or tension forces in the tendons of the abductor gluteal muscles. To present age and gender comparable to the intervention group	Presenting a body mass index more than 36 kg / m2, received some type of invasive intervention to reduce pain in the region evaluated in the last year, physiotherapeutic intervention in the last three months, present any limitation in the range of motion of the regions of the column, hip or MMII that disables gait or testing, any disease that affects the neuromuscular system or that may prevent collection, surgery on the spine or hip, any infectious condition, any neoplasia or can not commit to the weeks of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7vh96h	Effect of Physiotherapy on Muscular Force and Quality of life in patients who have Surgery of the Heart	Recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3440	Effect of Peripheral Muscular Training on Muscular Force, Functional Capacity and Quality of Life in individuals after Coronary Artery Bypass Graft	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-14	Universidade Federal de Alfenas	Hospital Santa Lúcia de Poços de Caldas	https://ensaiosclinicos.gov.br/rg/RBR-7vh96h	<NULL>	Volunteers with coronary artery disease; adults between 18 and 80 years; of both sexes.	Volunteers presenting with postoperative complications; with osteomuscular sequelae of stroke; osteomuscular sequelae that compromise the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-5w67pz4	Effect of physiotherapy with muscle strength, balance and walking training in elderly women with and without Knee arthrosis	Recruiting	Intervention	2021-08-04	<NULL>	<NULL>	4812	Effect of Therapeutic Intervention with muscle resistance training, balance and gait with visual feedback in elderly women with and without Knee Osteoarthritis: randomized clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-07-01	University Santo Amaro	University of São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5w67pz4	<NULL>	elderly women; ages between 60 and 80 years; grade 2 or 3 knee arthrosis; knee pain with intensity between 3 and 8; body weight index less than 35 kg/m2; walk independently	Lower limb prostheses and/or orthotics; fractures in the last six months; hip and ankle arthrosis; diabetic neuropathies; rheumatoid arthritis; tissue injuries; dementia pictures; physical therapy treatment with exercises during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-95xdzh	Effect of Pilates  exercises on glycemic indexes, urinary and sexual symptoms, mobility and quality of life of women with gestational diabetes mellitus	Recruiting	Intervention	2017-07-13	<NULL>	<NULL>	1490	Effect of Pilates  exercises on glycemic indexes, urinary and sexual symptoms, mobility and quality of life of women with gestational diabetes mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-02	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-95xdzh	<NULL>	Age above 18 years; literate; with clinical and laboratory diagnosis of gestational diabetes mellitus; with gestational age between 12 and 30 weeks; BMI &lt;/ = 45; sedentary; non-smokers; clinically stable;released by the physician to perform physical activities	"Pregnant women with neurological impairment; Endocrine and metabolic complications
Due to DMG; obstetric complications such as systemic arterial hypertension, placenta previa, among others; Presenting pre-existing diabetes (type 1 or 2); heart disease; non-attendance at evaluation; Have more than 25% of absences to the treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4j62sf	Effect of Pilates and Exercises for trunk muscles in elderly people with low back pain	Recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3783	Effect of the Pilates method and Segmental Stabilization in the elderly with non-specific chronic Low back pain: randomized clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-05-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4j62sf	<NULL>	Both genders; age over 60; nonspecific low back pain for at least 3 months; pain intensity equal to or greater than 3 cm	Specific low back pain; neurological involvement (radiculopathy or myelopathy); previous spine surgery; impediment to performing exercises; recent surgery; being under treatment for low back pain; body mass index (BMI) greater than or equal to 27; not being able cognitive to perform the exercises or be submitted to the proposed evaluations; missing the attendance three times in a row	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-5454tsk	Effect of Pilates and Walking on the pelvic muscles of postmenopausal women	Not yet recruiting	Intervention	2024-10-23	<NULL>	<NULL>	7453	Effects of Pilates and Aerobic Exercise on the pelvic floor musculature in postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5454tsk	<NULL>	Postmenopausal woman with 1 to 10 years of amenorrhea; having a cardiometabolic condition (hypertension, diabetes, high cholesterol, or being overweight); and having a medical clearance to engage in physical activities	Have physical problems or cardiovascular complications that prevent them from performing physical exercises; a history of stroke or acute myocardial infarction; renal pathologies; use medications that affect lipid metabolism; are smokers; have intolerance to vaginal palpation and/or the insertion of a pressure manometer; presence of neurological and/or cognitive impairments that hinder understanding of the proposed procedures; undergoing physical therapy for pelvic floor dysfunctions  before and during the participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-7bvrzp7	Effect of Pilates compared to Pelvic Floor Muscle Training on urinary incontinence, pelvic floor muscle strength and respiratory in elderly women: a randomized clinical trial	Recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5651	Assessment and intervention through Physical Activity and Physical Therapy in elderly women with and without pelvic floor dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7bvrzp7	<NULL>	Being female; being between 60 – 79 years of age; presence of voluntary contraction of the pelvic floor muscles at least grade 2 defined as weak perineal contraction weak contraction on palpation; preserved cognitive function verified by the Mini Mental State Examination (MMSE) scored according to education level	Are currently or recently (less than 6 months) undergoing physical therapy intervention for symptoms of urinary loss and/or are practicing another modality of physical activity with the exception of walking; presence of urge urinary incontinence due to neurological causes or self-reported urinary tract infection; smoking habits; chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD); asthma; bronchitis; occupational lung diseases and pulmonary hypertension; presence of diseases that constitute contraindications for the performance of Mat Pilates exercises; such as decompensated arterial hypertension; advanced arthrosis; fibromyalgia and surgeries; recent ligament fractures or rupture; advanced disc protrusion and advanced postural deviations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-7b3jdc	Effect of pilates exercises on patients with Plantar Fasciitis	Recruiting	Intervention	2020-08-25	<NULL>	<NULL>	8267	The effects of the Pilates method with  Plantar Fasciitis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7b3jdc	<NULL>	Women, between 40 and 65 years of age; diagnosis of chronic Plantar Fasciitis with a minimum duration of symptoms of four months; with unilateral or bilateral pain; who present pain of at least three on the numerical pain scale; pain at the insertion of the plantar fascia, especially with the first steps in the morning and after a period of rest without weight bearing; pain at the insertion of the plantar fascia, after more intense physical activity with weight bearing; pain on palpation at the insertion of the plantar fascia at the medial tubercle of the calcaneus; positive Windlass test; individuals who are able to be accompanied by a close relative or friend, of legal age, throughout the participant&apos;s remote intervention period	Differential diagnoses for Plantar Fasciitis, such as Atrophy of the heel fat pad and proximal plantar fibromatosis; injuries and/or trauma to the lower limbs that have occurred less than six months ago; previous surgery to the lower limbs; conditions that prevent the performance of physical exercise such as neurological, cardiovascular, orthopedic or rheumatological diseases; pregnancy; those who are undergoing any treatment for Plantar Fasciitis and/or regular activities that involve Pilates exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-3253dz	Effect of Pilates Method on muscle strength, activities of daily living, amount of fat, and quality of Life in women undergoing treatment for Breast Cancer	Recruiting	Intervention	2019-02-15	<NULL>	<NULL>	2483	Effect of Pilates Method on Biomechanical, Functional, Body Composition and Quality of Life in women undergoing treatment for Breast Cancer: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3253dz	<NULL>	To be part in this study participants have to be forty years or older, have breast cancer stage one to three certified by the physician and recorded in the medical promptuary; undergoing hormonetherapy, to have an authorization to practice Mat Pilates and the tests; live in the city of Presidente Prudente; not have practiced any type of systematic physical activity six month before the study, and sign the consent form	Participants will be excluded if they have three consecutive non attendance to the intervention; more than seventy five percent of absents within a month during the  intervention; physical impairments to perform the tests and the Mat Pilates intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-7h672c9	Effect of Pilates on strength and movement in Crossfit practitioners	Data analysis completed	Intervention	2024-07-29	<NULL>	<NULL>	7165	Effect of Pilates on strength and range of movement in extreme conditioning practitioners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal do Triangulo Mineiro	Universidade federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7h672c9	<NULL>	Individuals of both sexes; Age 18 or over years; Healthy; Practicing extreme conditioning program (ECP) for at least month; Who are enrolled and present at these academies on the day of the assessment; Agree to participate in the research and sign the Informed Consent Form	Beginners who do not attend the reevaluation; Beginners who stop practicing the activity during the study; Volunteers who experience discomfort or restrictions when performing any of the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-384qgtn	Effect of Pilates on the balance of elderly women	Recruitment completed	Intervention	2021-06-01	<NULL>	<NULL>	4711	Influence of the Pilates Method on balance parameters in elderly women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-384qgtn	<NULL>	To be, at the time of the assessment, 60 years old or more, residing in Marília, having autonomy and independence compatible for carrying out the tests without external aids, having no walking restriction or using auxiliary devices for the same; have the ability to stand for at least 90 seconds; have cognitive ability assessed by the Mini-Mental State Examination.	Elderly people with neurological pathologies who have a pathological gait, have an uncorrected neurological and / or orthopedic disorder; not signing the Informed Consent Form; not having cognitive ability assessed by the Mini-Mental State Examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-9j64v4y	Effect of Platelet-Rich Fibrin (PRF) on Post Tonsil Surgery Pain	Recruitment completed	Intervention	2025-03-17	<NULL>	<NULL>	7844	Effect of Platelet-Rich Fibrin (PRF) on Post-Tonsillectomy Pain	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-11-01	Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	https://ensaiosclinicos.gov.br/rg/RBR-9j64v4y	<NULL>	Age equal to or over 18 years old. Indication for tonsillectomy. Signing of the Free and Informed Consent Form (ICF). Both sexes	Refusal to sign the Informed Consent Form (ICF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-10m7c788	Effect of Platelet-Rich Fibrin on the stability of Bone Graft and soft tissues around dental implants: a randomized clinical trial	Not yet recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5631	Guided Bone Regeneration in the maxilla with the use of Xenogeneic Graft associated or not with Platelet-Rich Fibrin: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade Paulo Picanço	Faculdade Paulo Picanço	https://ensaiosclinicos.gov.br/rg/RBR-10m7c788	<NULL>	Volunteers aged between 20 and 80 years; both genders	Partially dentate volunteers; with jaws without adequate bone height; uncontrolled systemic disease; smokers; history of radiation in the treatment area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-10dnk8pg	Effect of Polydextrose consumption on the composition of intestinal bacteria and blood sugar control in patients with Gestational Diabetes Mellitus	Recruiting	Intervention	2025-04-29	<NULL>	<NULL>	7971	Effect of Polydextrose consumption of the intestinal microbiota,  inflammatory and oxidative stress markers, immune profile, and glycemic control of patients with Gestational Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-20	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani de São Thiago - HU/UFSC/EBSERH	https://ensaiosclinicos.gov.br/rg/RBR-10dnk8pg	<NULL>	Adult patients over 19 years of age, with GDM diagnosed between 24 and 28 weeks of gestation by OGTT, who have a eutopic pregnancy, with only one embryo and who accept and sign the Informed Consent Form (TCLE).	Exclusion Criteria: Alcoholism, alcoholism, drug use, presence of fetal malformations, psychiatric, neurological, autoimmune, renal, hepatic diseases, inflammatory bowel diseases, previous type 1 or 2 Diabetes Mellitus, immunodeficiencies, allergies or food intolerances, hyperemesis gravidarum, use of anti-inflammatory drugs in the last 30 days and use of antibiotics and supplements or complements containing pre, pro or synbiotics in the last 90 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-6nt4hkm	Effect of Postural Insoles on Women&apos;s Muscle Health	Recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8444	Effect of postural insoles on fibroedemagelloid, muscle strength and trophism in women: Double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-10	Universidade Federal de Alfenas - UNIFAL-MG	Universidade Federal de Alfenas - UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-6nt4hkm	<NULL>	Participants must be female; aged between 18 and 45 years at the date of assessment; have signed the informed consent form; report fibroedemageloid, confirmed using a validated scale; women who are menstruating on the day of assessment will not be included and will be rescheduled for a new date	Pregnant women; women in menopause; with history of orthopedic injury and/or surgery in the lower limbs within the last six months; dermatological lesions such as ulcers or surgical scars; undergoing aesthetic treatment in the evaluated region; history of neurological, rheumatological, or endocrine diseases diagnosed within the last year; volunteers who have not signed the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-3mcdzwg	Effect of practicing Auriculotherapy on tremors and motor symptoms in elderly people with Parkinson&apos;s disease: a case-control study	Not yet recruiting	Intervention	2023-10-04	<NULL>	<NULL>	6483	Effect of Auriculotherapy on the motor symptoms of elderly people with Parkinson&apos;s: Case-control study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade do Estado do Rio Grande do Norte	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3mcdzwg	<NULL>	Individuals over 60 years of age; of both sexes; with a diagnosis of Parkinson&apos;s disease with medical report by a neurologist, in regular outpatient follow-up; absence of other neurological disorders or comorbidities that could affect gait; absence of dementia; vision and hearing adequate or corrected to normality; be available to participate in activities and time availability for submission to intervention sessions	Individuals with uncompensated morbidities; having physical problems and/or impairments that could be aggravated during the intervention, such as a history of vestibular disease, psychiatric disorders, unilateral or bilateral hearing deficit; having a cognitive disorder; severe change in visual acuity and/or history of stroke; who have an infection, inflammation or injury to the ear; make use of piercing (except normal earring); refusal to receive auricular treatment using mustard seeds; not responding to three contact attempts made by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-4t4bcvy	Effect of Pre-treatment with Aluminum Oxide on dentin and adhesive strategies on the clinical performance of Restorations in Non-carious Cervical Lesions	Recruitment completed	Intervention	2024-07-30	<NULL>	<NULL>	7167	Effect of Air Abrasion Aluminum Oxide on dentin and Universal Adhesive System with different adhesive strategies on the clinical performance of Restorations in Ron-carious Cervical Lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-24	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4t4bcvy	<NULL>	Minimum age of 18 years;  both genders; good oral hygiene; at least 20 teeth in occlusion; at least four teeth with non-carious cervical lesionswith antagonists; non-carious cervical lesionswith antagonists with a depth of at least 1 mm (TWI index 3 and 4)	Severe periodontal disease; cavities; xerostomia; medical problems that prevent them from attending review appointments; active bruxism; endodontic treatment in the tooth with a non-carious cervical lesion; patients with orthodontic appliances; have had teeth whitening in the last 6 months; pregnancy and/or lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-466xzz	Effect of preemptive analgesia and desensitization to control painful sensitivity after tooth bleaching	Recruitment completed	Intervention	2020-03-25	<NULL>	<NULL>	3656	Effect of preemptive analgesia and Potassium Fluoride desensitization to control painful sensitivity after tooth bleaching: a controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-10	Universidade de Pernambuco - campus Arcoverde	Universidade de Pernambuco - campus Arcoverde	https://ensaiosclinicos.gov.br/rg/RBR-466xzz	<NULL>	Healthy anterior teeth and not restored; Tooth sensitivity up to Degree 2 in the Schiff index after an air jet; Absence of hypoplasia and teeth stained by fluorosis or tetracycline; having signed the Informed Consent Form	Pregnancy; Lactation; To have a fixed orthodontic appliance; Have previous experience with tooth whitening; Have used any antiinflammatory drug in the last 15 days; have periodontal disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-7zmz3y	Effect of pressure splint on spasticity in the stroke	Recruitment completed	Intervention	2018-09-25	<NULL>	<NULL>	2231	Immediate effect of Johnstone pressure splint and the inhibition techniques on spasticity of plantiflexores in the stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidad Industrial de Santander	Universidad Industrial de Santander	https://ensaiosclinicos.gov.br/rg/RBR-7zmz3y	<NULL>	Age 50 to 70 years, minimal time course of evolution 6 months to 4 years, plantar flexor muscles tone up to  3 according to the Modified Ashworth Scale (MAS), Barthel Index score greater than 60, independent gait pattern with or without ambulation aids, and the ability to perform the sit to stand movement independently	Altered cognitive ability according to the Short Portable Mental Status Questionnaire or inability to follow commands; Botulinum toxin injection 6 months before the study; diabetic polyneuropathy; lower limb pain and hyperalgesia; peripheral vascular disease, fractures or musculoskeletal lesions in the paretic lower limb; and consumption of muscle relaxant drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-52h647m	Effect of PRF as a complementary therapy in the treatment of periodontal disease	Not yet recruiting	Intervention	2022-03-02	<NULL>	<NULL>	5250	Effect of PRF as adjunctive therapy to scaling and root planing in the treatment of periodontitis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia - Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-52h647m	<NULL>	Patients with Stage III Periodontitis, with 5 mm or more of interproximal attachment loss or radiographic bone loss extending to the apical half or third of the root; may have vertical bone loss of up to 3 mm; grade II or III furcation lesions and moderate ridge defect; direct evidence of non-progression of attachment loss for 5 years or indirect evidence of bone loss/year up to 0.25 mm; patients with large accumulation of biofilm but little periodontal destruction; minimum of 20 teeth present and presence of two pairs of contralateral teeth with proximal periodontal sites presenting probing depth and clinical attachment level ≥ 5 mm	Underage patients; patients who do not agree with the informed consent and do not sign it; tooth loss of 5 or more teeth due to periodontitis; positive history of antibiotic therapy in the last six months; positive history of nonsurgical periodontal therapy in the last six months; systemic involvement that may interfere with disease progression or response to treatment; need for antibiotic prophylaxis for routine dental procedures; use of anti-inflammatory drugs for a long period of time; smoking; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-6z4jrs8	Effect of Prior Administration of the drug Ibuprofen-Arginine on the success of Anesthetic Block for Root Canal Treatment of posterior lower teeth with Symptomatic Pulpitis	Recruitment completed	Intervention	2023-07-07	<NULL>	<NULL>	6215	Effect of Preemptive Administration of Ibuprofene-Arginine on Anesthetic Block of the inferior alveolar nerve for Endodontic Treatment of teeth with Symptomatic Pulpitis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6z4jrs8	<NULL>	Be in good health; Be in the age group over 18 years; Present a clinical diagnosis of symptomatic pulpitis in posterior lower teeth; Ability to understand the pain assessment scale	Under 18 years old; pregnant women; Patients who have a previous sensitivity, allergy or who cannot take ibuprofen for any other reason; Patients allergic to local anesthetics or sulfites; Patients who have an important history of health problems; Patients unable to give informed consent; Patients who have ingested analgesics or anti-inflammatory drugs in the last 8 hours prior to treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-836wwd	Effect of prior application of 10% potassium nitrate in reducing tooth sensitivity resulting from in-office dental bleaching: a randomized clinical trial, triple blind, placebo-controlled, split-mouth	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	790	Preoperative application effect of 10% potassium nitrate reduction in tooth sensitivity resulting from in-office dental bleaching: a randomized clinical trial, triple blind, placebo-controlled, split-mouth	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-26	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-836wwd	<NULL>	Patients older than 18 years are included; with good oral and general health; with the maxillary anterior teeth free restorations and presenting no carious lesion; which possess the color of teeth A2 or darker depending on the color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening; pregnant patients or lactating; who report tooth sensitivity; severe browning (staining by tetracycline, fluorosis or endodontics); with deleterious habits; people with dental prostheses and orthodontic appliances and any other oral pathology . Although patients will be excluded that present systemic changes such as stomach, heart, kidney and liver problems, diabetes, hypertension or are making continual use of drugs with analgesic and anti-inflammatory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-98yskk7	Effect of prior knowledge about a Caries-arresting product on caregivers&apos; opinion and acceptance regarding the appearance of children&apos;s primary teeth after use	Data analysis completed	Intervention	2025-04-02	<NULL>	<NULL>	7877	Influence of prior knowledge about a substance that arrests Caries on caregivers&apos; acceptance and impression regarding the appearance of its use on children&apos;s primary teeth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-98yskk7	<NULL>	Guardians and caregivers of children aged between 1 and 5 years; who are treated at the Clinic for Babies and Children in Early Childhood of the School of Dentistry of the Federal University of Rio de Janeiro; both sexes; who agree to participate in the study	Guardians and caregivers of children involved in clinical studies in which silver diamine fluoride was one of the investigated interventions; who had already been treated with silver diamine fluoride; those with visual impairments; who do not own smartphones	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-32v2gm5	Effect of Probiotic and Sorghum Beverage on Metabolic Responses of Normal Weight and Overweight Individuals	Not yet recruiting	Intervention	2023-04-05	<NULL>	<NULL>	5985	Effect of Probiotic (Lactobacillus rhamnosus) and Symbiotic Beverage with Extruded and Germinated Sorghum ([Sorghum bicolor (L.) moench]) on Metabolic Responses of Adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-32v2gm5	<NULL>	fasting capillary blood glucose ranging from 70 to 99 mg/dL; regular breakfast intake; Body Mass Index (BMI) between 27 and 34.9 kg/m²; body fat percentage &gt; 30% for females and &gt; 20% for males; increased waist circumference; have a level of light physical activity; level of food restriction/disinhibition ≤ 14	smokers; alcohol consumption greater than 2 doses/day (&gt; 50g of ethanol/day); use of medications that affect blood glucose, energy metabolism or appetite; use of medications, herbs, or diets to reduce appetite and body weight; weight instability (gain or loss of more or less 3 kg in the 3 months prior to the beginning of the study); recent change in physical activity level; aversion, intolerance or allergy to food provided in the study; existence or history of recent digestive, liver, kidney, cardiovascular, thyroid or inflammatory diseases, diagnosis of cancer in the previous year; report of eating disorders; pregnant or lactating; use of laxatives or antibiotics in the three months prior to the beginning of the study; continuous use of anti-inflammatory drugs and/or corticosteroids; use of probiotics, prebiotics or synbiotics (&gt; 2 times a week) in the month prior to the beginning of the study; menstrual irregularity three months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-6ztyb7	Effect of Probiotic consumption in individuals with Heart Diseases	Recruitment completed	Intervention	2020-02-20	<NULL>	<NULL>	8147	Effect of Probiotic supplementation in individuals with Cardiovascular Diseases	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Faculdade de Ciências da Saúde da Universidade Federal da Grande Dourados	Universidade Federal da Grande Dourados - UFGD	https://ensaiosclinicos.gov.br/rg/RBR-6ztyb7	<NULL>	Volunteers aged 20 or over; both sexes; undergoing Myocardial Revascularization for Atherothrombotic Coronary Artery Disease	Previous gastrointestinal diseases; Chronic kidney disease on dialysis; food intolerances or food allergies; alcohol or illicit drug addiction; current or previous use (up to three months) of antibiotics, laxatives and appetite suppressants; regular use of antispasmodics or antacids; current or previous use (up to three months) of dietary fiber modules, prebiotics, probiotics, synbiotics or products enriched with these ingredients; present intolerance to prebiotics, probiotics, synbiotics; pregnant or lactating women; current follow up of unusual diets (vegetarian, paleolithic, gluten free, lactose free, macrobiotic); indigenous people	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-9gzqp3v	Effect of Probiotic Mixture Supplementation on Constipation	Data analysis completed	Intervention	2024-10-31	<NULL>	<NULL>	7470	Effect of Probiotic Mix Therapy on Intestinal Constipation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-19	Faculdade de Nutrição - Universidade Federal de Goiás	Faculdade de Nutrição - Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9gzqp3v	<NULL>	Women; age between 20 and 59; self-reported stool types two to four on the Bristol Stool Scale; who had at least two of the criteria on the Rome IV Index	Women undergoing bariatric surgery; history of persistent diarrhea or inflammatory bowel disease; irritable bowel syndrome; vegetarian or on a diet; regular alcohol consumption (&gt; 7 drinks/week); smokers; moderate or vigorous exercise &gt; 3 h/week; use of antibiotics, laxatives, immunosuppressants, diuretics and antacids within one month before the start of the intervention; use of probiotic, prebiotic or symbiotic supplements; use of fermented foods during this same period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-9qxx9j	Effect of probiotic use on obesity-associated diseases	Recruiting	Intervention	2020-02-17	<NULL>	<NULL>	3523	Effects of probiotic supplementation on obesity-associated metabolic and immunological changes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-19	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-9qxx9j	<NULL>	Both genders; aged 20 years and over; accept the terms of the informed consent form IC; Waist circumference&gt; 102 cm for men and&gt; 88 cm for women; Blood pressure&gt; 130 mmHg or&gt; 85 mmHg; history of hypertension; Triglycerides&gt; 150 mg / dL; patients on drug treatment for elevated triglycerides; HDL-cholesterol &lt;40mg / dL for men and &lt;50mg / dL for women or on drug treatment for low HDL levels; Blood glucose&gt; 100mgdL or in drug treatment for hyperglycemia. AST greater than 31 U / L (women) and 37 U / L (men) and / or ALT greater than 31 U / L (women) and 41 U / L (men).	Body Mass Index (BMI) greater than or equal to 40; Use of commercial probiotics consumed in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-4m9yf5k	Effect of probiotics and yoga practice on metabolic syndrome in menopausal women	Not yet recruiting	Intervention	2024-03-06	<NULL>	<NULL>	6837	Effect of Probiotics and Yoga Practice on Metabolic Syndrome in Climacteric Women and assessment of associated epigenetic mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-4m9yf5k	<NULL>	Climacteric women; age between 40 to 65; diagnosis of metabolic syndrome according to the Joint Interim Statement (JIS) criteria	Diagnosis of lactose intolerance or cancer; women who have engaged in yoga practice within the current or past 12 months; women who have used probiotics within the current or past 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-2qvnq9	Effect of Probiotics on intestinal health in adults and healthy adults	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2699	Effect of Probiotics on intestinal health in adults and healthy adults: Influence of the type of cepa, dose and method of administration	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-13	Patrícia Borges Botelho	Cifarma Científica Farmacêutica LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2qvnq9	<NULL>	Men and women aged 19-70 who have low evacuation frequency (2-4 days \ week) and general abdominal discomfort	Volunteers who have diagnosed diseases in the GIT or complications of surgeries resulting from these diseases; presence of hepatic or renal dysfunction; those who have used antibiotics in the last four weeks. Have used in the last four weeks drugs or vitamins or minerals or herbal foods or supplements to reduce digestive symptoms. Those who consumed food containing probiotics and prebiotics before and during the intervention. Volunteers consuming nutraceutical foods with anti-inflammatory activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-3hkxkc7	Effect of Probiotics on the Health Parameters of Cardiac Individuals	Not yet recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8784	Effect of Probiotic supplementation on inflammatory markers and cardiovascular risk, indicators of nutritional status, and clinical parameters in individuals undergoing Cardiac Surgery	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Faculdade de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Patients requiring revascularization; adults and elderly; of both sexes; undergoing surgical treatment for cardiovascular disease or following an acute coronary event. Eligibility will be confirmed through analysis of the participant&apos;s medical record and by questioning the participant	Individuals following unusual diets; those with food intolerances or allergies; and those using drugs or supplements that can directly alter the immune system, gut microbiota, and appetite, as these are confounding or effect-modifying factors in this type of intervention. Patients with morbid obesity; uncontrolled blood glucose or cholesterol levels. Probiotic intake for less than three months. Inability to comply with the study procedure. As a discontinuation criterion, participants who go for two consecutive days or more without consuming the supplement	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4zvg678	Effect of Propolis Extract Supplementation and Combined Training on Chronic Low-Grade Inflammation and Oxidative Stress in Postmenopausal Overweight and Obese Women	Not yet recruiting	Intervention	2024-08-23	<NULL>	<NULL>	7262	Propolis and Exercise Training combined on Chronic Low-grade Inflammation and Oxidative stress in Overweight and Obese Postmenopausal Eomen	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-20	Pró Reitoria de Pesquisa da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4zvg678	<NULL>	Women aged between 60-79 years;  BMI between 25 and 30 kg/m2; not practicing resistance training (&gt; 6 months without practice); without weight change in 6 months; non-smoker for more than 1 year; without history of cancer, cardiorespiratory disease, uncontrolled hypertension (SBP ≥160 mmHg and DBP ≥120 mmHg)	Have any gastrointestinal discomfort or hypersensitivity to the use of propolis supplementation; have any musculoskeletal discomfort with combined training;not perform the proposed tests before and after the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-876w38c	Effect of Propolis in patients with Angina	Recruiting	Intervention	2022-08-08	<NULL>	<NULL>	6054	Effect of Green Propolis Extract (EPP-AF) in patients with Chronic Stable Angina. A randomized, blinded pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Hospital Ana Nery	Hospital Ana Nery	https://ensaiosclinicos.gov.br/rg/RBR-876w38c	<NULL>	Patients older than 18 years; with stable coronary artery disease (CAD) symptomatic of angina despite optimized clinical treatment for at least four weeks with antianginal drugs (beta-blockers; calcium channel blockers; nitrates and/or trimetazidine)	Patients scheduled for surgical or percutaneous myocardial revascularization within the next 30 days; patients with obstruction of the left main coronary artery greater than 50%; patients who had acute coronary syndrome in the last two months; electrocardiogram at rest with left bundle branch block (LBBB), Wolff-Parkinson White (WPW), pacemaker rhythm, ST-segment depression more than 1mm, digitalis therapy; patients who have some physical limitation that make it impossible to perform the exercise test on a treadmill; heart failure with symptomatic reduced ejection fraction NYHA III-IV	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-6ts54x	Effect of propolis on joint pain	Recruiting	Intervention	2020-02-17	<NULL>	<NULL>	3492	Analysis of the therapeutic effect of propolis in patients with joint pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Pós Graduação em Ciências da Saúde	Pós Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-6ts54x	<NULL>	Patients with clinical diagnosis of joint pain due to inflammation in the intra and / or peri-articular structures by a doctor and presence of pain caused by the disease mentioned during the initial evaluation, of both sexes and any ethnic group will be included in the study.	Exclusion criteria are: pregnant patients with a history of bee sting allergy and other therapies; hx of gastrointestinal bleeding, gastric perforation; kidney disease, liver disease; current history of alcoholism; use of anticoagulants; prosthetic implants or pacemaker; serious uncontrolled chronic diseases (high blood pressure, diabetes mellitus, heart disease and other diseases that, by their nature or by the proposed treatment, may interfere with the proposed assessment). Individuals who make use of various pharmacological therapies will be evaluated professional pharmaceutical pain able to understand possible pharmacological interactions, deciding for the insertion or exclusion of this individual in the current research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-7dmytc7	Effect of Propolis on Vascular and Muscular Health	Recruiting	Intervention	2024-12-17	<NULL>	<NULL>	7599	Effect of Supplementation with Green Propolis Extract on Vascular Health and Muscular Recovery in Humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-7dmytc7	<NULL>	Healthy adults and older adults; both sexes; minimum of three months of prior resistance training experience	Cardiovascular diseases; pulmonary; diabetes mellitus; hypertension; dyslipidemia; smoking; pregnant women; lactating women; use of drugs that interfere with NO production (synthetic estrogen, angiotensin-converting enzyme inhibitors); presence of osteoarticular lesions and use of supplements (creatine, caffeine, antioxidant vitamins, minerals); anabolic steroids or anti-inflammatory drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-2m7w87r	Effect of Protein and Carbohydrate Supplementation Associated with Resistance Exercise as a Treatment for Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2025-06-30	<NULL>	<NULL>	8087	Effect of Protein and Carbohydrate Supplementation Associated with Resistance Exercise as an Adjunct in the Treatment of Type 2 Diabetes Mellitus: A Randomized, Triple-Blind Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-19	Universidade São Judas Tadeu	Faculdade de Medicina da  Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2m7w87r	<NULL>	Diabetes Mellitus type 2 (DMT2)  with a stable medication dose (oral antidiabetics, insulin, or a combination of both) for three or more months; glycated hemoglobin between 6% and 9.0%; renal function assessed by the Modification of Diet in Renal Disease (MDRD) above 60 ml/h; no untreated or decompensated chronic non-communicable disease; male sex; age between 65 and 79 years	Inability to undergo assessments and reassessments; having more than three absences during the training period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-4hrqjf	Effect of protein supplementation and physical exercises in the amount of muscle and in the physical function of elderly with low strength	Recruitment completed	Intervention	2016-11-30	<NULL>	<NULL>	1081	Effect of protein supplementation and resistance training on muscle mass and strength and physical function in sarcopenic elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4hrqjf	<NULL>	Older adults, age sixty years or older; sarcopenic, hand grip strength lower than 20 kg for women and lower than 30 kg for man and/or gait speed lower than 0.8 m/s.	Cognitive deficit; illiteracy; immobilism;diagnoses of congestive heart failure, chronic kidney failure, cancer or descompensated diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-5jh9sf	Effect of psychological preparation in the preoperative anxiety in children undergoing ambulatory surgery	Data analysis completed	Intervention	2016-05-23	<NULL>	<NULL>	862	Effect of psychological intervention in the preoperative anxiety of preschool children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-06	Faculdade de Medicina de Jundiaí	Faculdade de Medicina de Jundiaí	https://ensaiosclinicos.gov.br/rg/RBR-5jh9sf	<NULL>	Children of both gender, aged 2-8 years classified as ASA I according to the American Association of anesthesiology, which were attended in the pre-anesthetic assessment clinic of the University Hospital of Jundiaí Medical School and undergoing surgery outpatient at the same hospital.	children with previous surgeries, the ones with confirmed behavioral and cognitive changes, users of psychoactive drugs, patients with history of convulsion, mental illness and chronic pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-76xrqj	Effect of psychotherapy on Heart Failure	Data analysis completed	Intervention	2019-09-20	<NULL>	<NULL>	2975	Mental health in Heart Failure: prevalent diagnoses and psychological intervention from short-term psychoanalytic listening	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-11	Faculdade de Medicina da Universidade Federal Fluminense	Clínica de Insuficiência Cardíaca Coração Valente	https://ensaiosclinicos.gov.br/rg/RBR-76xrqj	<NULL>	Patients over 18 years of age and of any NYHA functional class	Psychotherapy patients; with psychotropic use during intervention; severe neurological sequel; severe psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-9jkkvbb	Effect of purple grape juice on performance and muscle recovery in male runners	Data analysis completed	Intervention	2023-07-26	<NULL>	<NULL>	7409	Effect of purple grape juice (Vitis labrusca) consumption on parameters related to sports performance and exercise-induced muscle damage in runners	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9jkkvbb	<NULL>	Male; age between 18 and 45 years; trained runners with a history of participating in competitions at least once a year; run at least 5 hours a week	Smokers; carriers of any diseases, infectious or inflammatory processes; history of recent musculoskeletal injuries; users (the last 30 days will be considered) of vitamin supplements, minerals, ergogenic aids (such as carnitine, arginine, citrulline, taurine, creatine and caffeine, nitrate, beta-alanine and sodium bicarbonate) or chronic use medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-8gb3sfj	Effect of Rapid and Repeated Practice compared to Traditional Simulation on learning Cardiopulmonary Resuscitation by nursing students	Data analysis completed	Intervention	2025-02-26	<NULL>	<NULL>	7803	Effectiveness of simulation strategies in theoretical-practical learning about Cardiopulmonary Resuscitation for nursing students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-14	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8gb3sfj	<NULL>	Being regularly enrolled in the first year of the Bachelor of Nursing course at the School of Nursing at the University of São Paulo (EEUSP); be available to participate in the three stages of the study, the first being distance learning and the others in person; be at least 18 years old; both sexes	Having physical limitations that would prevent participation in the simulated practical activity; having participated in a Basic Life Support (BLS) course within the past two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-463byn	Effect of rapid maxillary expansion on the quality of life of children with obstructive sleep apnea and residual snoring.	Recruitment completed	Intervention	2020-07-26	<NULL>	<NULL>	4036	Effect of rapid maxillary expansion on the quality of life of children with sleep apnea.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-463byn	<NULL>	Healthy volunteers; both genders; age from 5 to 12 years; they were submitted to adenotonsillectomy; snoring more than 5x a week and maxillary atresia.	Cardiac and neuromuscular diseases; craniofacial malformations or chromosomal syndromes; hypertrophy of adenoid and / or lingual tonsil tissue after the surgical procedure with rhinopharynx or oropharynx obstruction above 50%; loss of teeth, dental caries and periodontal disease; patients using neurological drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-2ch5z38	Effect of reading an e-book by dentistry students to gain knowledge about early loss of anterior deciduous teeth and creation of a support and guidance tool for parents about dental trauma to baby teeth	Data analysis completed	Intervention	2025-08-05	<NULL>	<NULL>	8183	The use of a book in digital format by undergraduate students to acquire knowledge about the early loss of deciduous anterior teeth	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-11	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro UFRJ	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-2ch5z38	<NULL>	Students over 18 years of age; regularly enrolled in any period of the Undergraduate Dentistry course at the Federal University of Rio de Janeiro (UFRJ) in the second semester of 2023; both genders	Students under 18 years of age; who are not enrolled in any period of the Undergraduate Dentistry course at the Federal University of Rio de Janeiro (UFRJ) in the second semester of 2023	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-2xzzsj	Effect of realistic simulation on knowledge, satisfaction and self-confidence of nursing technical students	Recruitment completed	Intervention	2020-04-08	<NULL>	<NULL>	3718	Knowledge, satisfaction and self-confidence of nursing technical students from the use of realistic simulation: quasi-experimental study	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-10	Departamento de Enfermagem da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-2xzzsj	<NULL>	Students of the technical nursing course of the institution selected for the research	Students with professional experience in healthcare	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-9bwxcx	Effect of red and infrared light for localized fat reduction in the abdomen	Not yet recruiting	Intervention	2019-04-15	<NULL>	<NULL>	4190	Effect of Photobiomodulation on reduction of abdominal measurements: Clinical, randomized, controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-10	Associação educacional Nove de Julho	Associação educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-9bwxcx	<NULL>	Men and women, 25-45 years old, with BMI between 18.5 kg / m2 to 29.9 kg / m2 will be included; with abdominal fat equal to or greater than 20mm and who agree with the participation in the research by signing the consent form.	The following people will be excluded from this survey: those participants who are undergoing aesthetic treatments to reduce waist circumference; those who have been previously submitted to abdominoplasty or liposuction surgeries; those who are on a diet, in order to reduce their measurements; those people who engage in a physical activity more than two times a week; those who are using or have taken drugs or food supplements in last 90 days, in order to reduce their measurements and their weight, which may affect their lipid metabolism, appetite or nutrients absorption; those who have been submitted previously to oophorectomy; those with signs and/or symptoms of climacteric at the menopause; pregnant or lactating women; those participants who are not regular in attending the sessions; those participants who present metabolic dysfunctions (diabetes and thyroid disorders), cardiovascular problems (hypertension, cardiac insufficiency, arrhythmia, thrombosis, pacemaker use), respiratory issues (asthma, chronic obstructive pulmonary disease), haematological disturbances (anaemia), renal, non-alcoholic fatty liver disease, dermatological or digestive disorders (gastritis, ulcers); those with a history of oncological pathology; those with cognitive deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-628bsrm	Effect of regional Anesthetic Technique compared to Nerve Block on Pain for Extraction of primary molars with 2% Lidocaine: A Randomized Clinical Trial	Recruiting	Intervention	2022-07-15	<NULL>	<NULL>	5488	Anesthetic Efficacy of the Vestibular Infiltrative Technique versus Inferior Alveolar Nerve Block on Pain for Extraction of primary mandibular molars with 2% Lidocaine: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-02	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-628bsrm	<NULL>	Children between 6 and 9 years of age, without systemic involvement, ASA I and II, of both sexes, who have a clinical and radiographic indication for extraction of an erupted primary molar and lower molar and who agree to participate in the research. Each child will participate only once in the survey. The following clinical and radiographic inclusion criteria will be analyzed. Clinically: the presence of coronary destruction that makes restoration impossible or the proper use of absolute isolation for endodontic and restorative procedures; the presence of perforation of the pulp chamber floor. Radiographically; deciduous molars with carious lesions or defective restorations associated with signs or symptoms indicative of pulp necrosis, periapical or inter radicular lesion extending over 1/3 of the roots or involving the crypt of the permanent successor tooth; the presence of pathological resorption of more than 1/3 of one or more roots that contraindicate endodontics; the presence of at least one non-resorbed half-length root, previous endodontic failure the persistence of periapical or inter radicular lesion associated or not with clinical signs and symptoms; internal resorption.	Patients with acute pain or presence of odontogenic infection associated with systemic signs and symptoms and cases of urgency; Patients with a history of bleeding or blood clotting problems or who have used medication that alters blood clotting prior to the procedure; Patients with hypersensitivity or a history of allergy to the drugs used in the research; Patients with a history of asthma; Patients with a history of liver disease;Patients with a history of bisulfite allergy; Patients who have reported post-traumatic stress disorder or recurrent hospitalizations, who have a personality or anxiety disorder or a diagnosis of phobia; Patient with neurological disorders or communication difficulties; Patient whose guardian cannot accompany the child and answer the necessary information for the survey within 24 hours following the procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-9mzjcb	Effect of Reiki  (integrative and complementary practice of laying hand) on anxiety  of nursing academics	Data analysis completed	Intervention	2019-08-13	<NULL>	<NULL>	2869	Effect of Reiki on anxiety level of nursing academics	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-19	Curso de Enfermagem do Instituto de Biotecnologia da Universidade Federal de Goiás - Regional Catalão	Universidade Federal de Goiás - Regional Catalão	https://ensaiosclinicos.gov.br/rg/RBR-9mzjcb	<NULL>	Academics over 18, of both sexes; not participating in other extension projects that involve integrative and complementary practices; which are compatible with the days of application of the reiki technique.	infectious and communicable diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-5wq4msw	Effect of Reiki and Sweet Orange smell on the mental health of women after menopause	Recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7031	Effect of Reiki Therapy and Inhalation of Citrus sinensis Essential Oil evaluation on Post Menopause women mental health	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-02	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-5wq4msw	<NULL>	Being post menopausal. Have a maximum post-menopause time of 10 years. Not taking hormonal treatment for menopause. Have a score greater than or equal to 10 points on the Beck Anxiety Inventory and or have a score greater than or equal to 11 points on the Beck Depression Inventory	Diagnosed with diabetes and or neoplasms for at least 5 years and severe cardiovascular diseases; those who are allergic to C. sinensis essential oil; take the following medications: metformin, enalapril, levothyroxine T4, puran T4, levothyroxine, insulin, inhaled fenoterol B2, amitriptyline, alprazolam (or frontal), losartan, hydrochlorothiazide (or chloran), relaxing herbal medicine, sertraline, captopril, vasopril, pondera, buspirone, amlodipine, fluoxetine, salbutamol, valsartan, domperidone, promethazine, citalopram, chlorthalidone, atenolol, ablok plus, aradois, rosuvastatin, zolpidem, copressotec, desvenlafaxine, clonazepam, diovan, minipres, euthyrox, venlafaxine, paroxetine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-89z57d	Effect of Reiki on people&apos;s well-being and feelings	Not yet recruiting	Intervention	2019-01-16	<NULL>	<NULL>	2446	Reiki&apos;s interference in subjective well-being and positive and negative feelings	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-09	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-89z57d	<NULL>	To be a server of the Federal University of Sergipe; to have never experienced therapy before; to be 18 years or older; to read and write; to commit voluntarily to four sessions of Reiki and; to respond to the instruments of collection of data	As exclusion criteria, physical and intellectual inability to respond to the questionnaires that were applied and to be on vacation or on leave in the institution was considered as exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-888hg2v	Effect of Reiki on the anxiety of Nurses working in Intensive Care Units	Recruitment completed	Intervention	2023-11-14	<NULL>	<NULL>	6572	Effects Reiki on Anxiety of Intensive Care Nurses	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-07	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-888hg2v	<NULL>	Nurses of both sexes who report or refer to feeling anxious during the interview will be included; those who have some degree of anxiety evidenced by IDATE and nurses with at least 1 year of experience in the ICU will also be included; the nurse will be included in the research regardless of the use of psychotropic medications and psychological support, so that our research does not interfere with their treatment	Professionals who have been away for more than six consecutive months in the last year; professionals who are on vacation or away during the execution of the research and participants who, through self-report, have a mental disorder, other than anxiety, will be excluded, according to sociodemographic instrument	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-458mtdb	Effect of reiki on the subjective well-being of nursing professionals in an emergency: randomized clinical trial	Data analysis completed	Intervention	2024-08-21	<NULL>	<NULL>	7244	Evaluation of the effect of reiki on the subjective well-being of nursing professionals in emergency services: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-458mtdb	<NULL>	Both genders; minimum age of 18; nursing professionals with at least three months work in the unit	Nursing professionals who are away for various reasons (vacation, leave, health, pregnancy); those who are merely replacing another professional in the unit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-3mnn2t4	Effect of reinforcement fiber on post-operative sensitivity of Bulk-Fill resin restorations in posterior teeth: a double-blind randomized clinical trial	Recruitment completed	Intervention	2025-10-20	<NULL>	<NULL>	8428	Effect of fiber reinforcement on postoperative sensitivity in Class I and II posterior teeth restorations using the Bulk-Fill technique: a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Odontologia da Universidade Federal do Amazonas.	Faculdade de Odontologia da Universidade Federal do Amazonas.	https://ensaiosclinicos.gov.br/rg/RBR-3mnn2t4	<NULL>	Volunteers over the age of 18, of both sexes, without systemic diseases, with good oral hygiene conditions, and without periodontal disease. Regarding dental aspects, volunteers must present at least one posterior vital tooth, with no history of previous dentin hypersensitivity, presenting either a carious lesion requiring restoration or a deficient posterior restoration that needs replacement (due to caries, fractures, or reasons reported by the patient). The lesions must be classified as Class I or II (involving the occlusal surface), with a minimum depth of 2 mm, which will be assessed through digital bitewing radiographs and a millimeter ruler. In addition, the teeth requiring restorative treatment must have an antagonist tooth in occlusion	Participants who require endodontic treatment (to be assessed by radiographic examination and cold pulp vitality test), as well as those who have already undergone endodontic therapy in the tooth in question, and those presenting with periodontal problems. Pregnant or breastfeeding participants, individuals with a history of allergy to any of the materials to be used in the research, participants with bruxism or significant oral pathologies, participants with non-carious cervical lesions, and those currently using or who have used anti-inflammatory drugs, analgesics, or psychotropic medications (as these may mask the results of postoperative sensitivity) within the 15 days prior to the restorative procedure will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4dfxtmt	Effect of residency training on health and functionality in the elderly	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4970	The effectiveness of home based physical training on variables related to health and functional capacity of the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-13	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4dfxtmt	<NULL>	seniors able to practice physical activity; over 60 years old; able to answer the study questionnaires and perform the proposed tests; have internet access	Elderly who have or acquire diseases and/or physical-motor and/or intellectual problems and symptoms that make it impossible to apply the questionnaires and/or perform evaluation tests and physical activities; seniors who do not attend at least 75% of classes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-66jx3m	Effect of resistance training on balance and muscular strength of the elderly	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1991	Assessment of the balance and muscular strength of the elderly before and after resistance training: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-09	Universidade Federal do Pampa	Universidade Federal do Pampa	https://ensaiosclinicos.gov.br/rg/RBR-66jx3m	<NULL>	"Volunteers of both genders, aged 60 or
over, ability to stand and walk
independently"	"Volunteers who have any type of
amputation, no independent gait, body mass index (BMI) below 18.5 kg / m2; have been engaging in physical activity in the past 6 months
uninterrupted; hypertensive or with blood pressure values greater than 180mmHg
systolic and diastolic blood pressure
90 mmHg"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-8zz8fw	Effect of Resistance Training on Blood Pressure in adolescents	Recruitment completed	Intervention	2019-12-02	<NULL>	<NULL>	3241	Responses and Adaptations of a Resistance Training Program in reducing Cardiovascular Risk Factors and their relationship with Post-exercise Hypotension in school adolescents in the city of Lagarto-SE	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8zz8fw	<NULL>	Healthy volunteers; Both genders; non smokers; age between 18 and 60 years	Sick volunteers; presence of secondary hypertension; pregnant teenagers; age over 18 years; resistance training practitioners; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-26cnqdt	Effect of resistance training with different exercises on muscle strength and selective hypertrophy of the quadriceps femoris	Not yet recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7377	Chronic effect of different exercises on strength and selective hypertrophy of the quadriceps femoris	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-26cnqdt	<NULL>	Men; university students; aged between 18 and 35 years; body mass index less than 30 kg/m2; physically active; no restrictions on the practice of physical exercise; with previous experience in resistance training but who have not been training in the last six months; no history of osteomyoarticular injury of the lower limbs in the last twelve months; who have not used any ergogenic resource in the last twelve months	Subjects who do not achieve 85% adherence to training sessions; use supplements; engage in other high-intensity counter-resistance activities during the experimental period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-9d5cr6	Effect of respiratory exercise in children with leukemia under treatment without heart control.	Recruitment completed	Intervention	2019-09-03	<NULL>	<NULL>	2925	Effects of Respiratory Kinesiotherapy in children with Leukemia undergoing treatment on Cardiac Autonomy.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-02-19	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9d5cr6	<NULL>	Children and adolescents on leukemia treatment; both genders; age range 4 - 15 years old.	Volunteers with lung, neurological, or drug-related illnesses in addition to those used to treat leukemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-1034kxcw	Effect of Respiratory Muscle Training on respiratory muscle strength and exercise resistance in patients with Acute Heart Failure in the hospital phase of cardiac rehabilitation	Not yet recruiting	Intervention	2024-04-18	<NULL>	<NULL>	6951	Effect of Inspiratory Muscle Training on Inspiratory Muscle Strength and Exercise Resistance in a Patient with Acute Heart Failure	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-24	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-1034kxcw	<NULL>	Patients diagnosed with heart failure; ventricular ejection fraction less than 40 percent; aged greater than or equal to 18 years; hospitalized for decompensated heart failure and clinically stable without the need for continuous ventilatory support	Decompensated lung diseases, pregnancy, head trauma, brain injury, cognitive impairment, neuromuscular disorders, hemodynamic instability with high dose of inotropes or acute coronary syndrome, presence of physical limitation that limits the performance of assessments and those who do not agree to sign the term of free and informed consent. Hemodynamic instability will be considered if systolic blood pressure is less than 90 mmHg or mean arterial pressure is less than 65 mmHg, peripheral hypoperfusion, heart rate is less than 40 or greater than 130 beats per minute, SpO2 is less than 88%, recent episodes of vomiting, complaints of dizziness or headache, high dose of dobutamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-9ttmzj	Effect of Respiratory Muscular Training of Mucopolysaccharidosis patients on movements and respiratory volumes, functionality and quality of life	Recruiting	Intervention	2019-08-28	<NULL>	<NULL>	2914	Effectiveness of Respiratory Muscle Training of patients with Mucopolissacaridose in toracoabdominal kinematics, respiratory function and mechanics, functionality and quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-25	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9ttmzj	<NULL>	Patients with a diagnosis of Mucopolysaccharidosis; confirmed by enzymatic dosing by blood test; from 6 to 60 years old; registered at the Breno Bloide Institute for rare diseases in the state of Pernambuco; Brazil; and who are over six years of age who agree to be part of the research and who sign the terms	Patients younger than six years of age and; over 60 years old; those who do not understand the controls for performing the evaluations will be excluded from the study; In relation to the specific evaluation tests; only those that are contraindicated for performing the specific test will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-2jkwm3x	Effect of respiratory physiotherapy maneuvers in preterm infants: Randomized Clinical Trial	Recruiting	Intervention	2021-12-30	<NULL>	<NULL>	5131	Effect of the application of the thoracoabdominal rebalancing method (RTA) in moderate premature infants: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Alfenas - UNIFAL	Hospital de Clínicas de Itajubá - HCI	https://ensaiosclinicos.gov.br/rg/RBR-2jkwm3x	<NULL>	Moderate premature newborn patients (32 to 36.6 gestational weeks; both sexes; weight up to 2.500g; admitted to the Neonatal Intensive Care Unit of the Hospital de Clínicas de Itajubá,  Minas Gerais); need for mechanical ventilation or not; with prescription respiratory physiotherapy physician, are not under analgesia and sedation.	Contraindication to respiratory physiotherapy, risk of intracranial hemorrhage; hemodynamic instability; blood dyscrasias; newborns with congenital malformations; genetic syndromes; those whose parents do not agree with the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-2nvbtvy	Effect of respiratory physiotherapy on the thoracoabdominal synchrony of premature newborn	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4976	Effect of respiratory physiotherapy on the thoracoabdominal synchrony of premature newborn - controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-20	Maternidade Instituto de Saúde Elpídio de Almeida- ISEA	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2nvbtvy	<NULL>	"RNPT; Who are in physiotherapeutic follow-up; indications for bronchial hygiene maneuvers in the presence of auscultation and/or mechanical ventilator charts showing changes suggestive of secretion; Only PTNB that are suitable for aspiration with a 6Fr gauge probe; Mothers aged 18 years and over; Only RNPT that are capable of aspiration with a 6Fr gauge probe.
·       Mothers aged 18 or over."	Present organic and structural changes, involving: chest deformities, necrotizing enterocolitis, skin lesion on the chest, hyperthermia, hypothermia, abdominal pathologies, congenital diaphragmatic hernia and the presence of a chest tube; PTNBs who do not complete any stage of the research procedure will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-9f6jkm	Effect of respiratory therapy in adults with bruxism and respiratory dificult during sleep	Recruitment completed	Intervention	2020-01-28	<NULL>	<NULL>	3696	Effect of respiratory therapy in adults with Bruxism patients and associeted respiratory events	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-02-15	Universidade Tuiuti do Paraná	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9f6jkm	<NULL>	"Patients aged 18 to 65 years;
Patients identified with sleep bruxism and associated respiratory events (apnea and mild to moderate hypopnea) by polysomnography."	Use of intraoral device; Associated severe apnea / hypopnea; Severe skeletal changes affecting upper airways; Chronic medical conditions that affect OSAHS such as stroke; Failure to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-54bvbb	Effect of respiratory training on quality of life of patients with traumatic spinal cord injury: a randomized controlled trial.	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2732	Effect of inspiratory muscular training on quality of life of patients with traumatic spinal cord injury: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-21	Universidade de Brasília-FCE	Universidade de Brasília-FCE	https://ensaiosclinicos.gov.br/rg/RBR-54bvbb	<NULL>	The male and female, with traumatic spinal cord injury, with complete injury  (ASIA A or B) between the C4 and T4 levels occurred for at least 6 months.	Patients in programming surgical, portators of cardiopatia or pneumoopatia, sleep with infecciosas agudas or com any descompensation clinical, sleep, patients have apresentable conditions of can impossibility the training muscular inspiratory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-27xb3b	Effect of restriction pressure on perceptual, metabolic and neuromuscular responses	Not yet recruiting	Intervention	2020-09-20	<NULL>	<NULL>	4266	Analysis of perceptual, metabolic and neuromuscular responses in resistance exercises with different levels of blood flow restriction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-27xb3b	<NULL>	Resistance training practitioners; healthy; male gender; age between 18 and 30 years; osteomioarticular lesions free in lower limbs.	Use of anabolic steroids; use of food supplements with ergogenic potential; inability to perform the knee extension and jump exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-5hjcyb	Effect of resveratrol associated with eriodontal treatment of patients with aggressive periodontitis.	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3587	"Influence of resveratrol associated with non-surgical periodontal treatment of
patients with aggressive periodontitis. Clinical, microbiological and
enzyme immunoassay."	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5hjcyb	<NULL>	"Diagnosis of generalized aggressive periodontitis verified by the presence
of true periodontal pockets and radiographic bone loss in patients up to 35 years of age, according to the criteria established by the Academy American Periodontics in 1999; Presence of at least eight teeth with probing depth equal to or above 5 mm (of which two teeth should have probing pocket depth iqual to or above 7 mm) and bleeding on probing;
Presence of at least 20 teeth in the oral cavity; Group approaches: Presence of at least two residual periodontal pockets, on posterior teeth without furcation involvement, with probing depth iqual to or above  5 mm and bleeding on probing, three months after non-surgical periodontal treatment."	"Periodontal treatment in the 6 months prior to the study; Use of medications, such as antibiotics, anti-inflammatory drugs
continuous use, phenytoin, cyclosporine, in the 6 months prior to the study; Presence of systemic changes or active infectious disease (diabetes, heart disease, hepatitis, etc.);
Presence of smoking habit; Pregnancy or breastfeeding; Group approaches: Presence of furcation injury; Presence of periapical or pulp changes; Presence of systemic changes or use of medications (6 months prior to the study) that may influence the response to periodontal treatment; Smoking patients; pregnant patients; Patients taking medications such as corticosteroids and antibiotics."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-87g6ny8	Effect of resveratrol combined on Exercise program on health-related outcomes of breast cancer survivors: randomized, double-blind clinical trial	Data analysis completed	Intervention	2021-12-08	<NULL>	<NULL>	5087	Effect of resveratrol combined on Exercise program on health-related outcomes of breast cancer survivors: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Pernambuco	Fundação de apoio à Ciência e Tecnologia de Pernambuco - FACEPE	https://ensaiosclinicos.gov.br/rg/RBR-87g6ny8	<NULL>	"Postmenopause; 
high BMI; 
sedentary lifestyle (mild physical activity, less than 150 minutes per week, American College of Sports Medicine 2014)"	"Recurrence of breast cancer;
 bone metastasis; 
bone fractures; 
severe anemia; 
platelet count less than 50x109ml; 
participation in other physical exercise programs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-3gt65c	Effect of resveratrol on periodontal disease treatment of smokers.	Recruitment completed	Intervention	2020-03-03	<NULL>	<NULL>	3553	Effect of resveratrol on non-surgical periodontal treatment of smokers diagnosed with Chronic Periodontitis. Prospective evaluation of clinical, microbiological, immunological results and quantification of neutrophils.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-11	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3gt65c	<NULL>	Diagnosis of generalized chronic periodontitis with at least 8 teeth with Probing Depth (PD) and Clinical Attachment Level (CAL) equal to or above 5 mm and Bleeding on Probing. Of these 8 teeth chosen, at least two teeth should present PD and CAL equal to or above 7 mm; Presence of at least 20 teeth in the oral cavity;Smoking cigarette for at least 5 years and at least 10 cigarettes per day.	Periodontal treatment in the 6 months prior to the study; Use of medications, such as antibiotics, continuous anti-inflammatories, phenytoin, cyclosporine, in the 6 months prior to the study; Presence of systemic changes or active infectious disease (diabetes, heart disease, hepatitis, etc.); Pregnancy or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-2pcvt4	Effect of Robotic Therapy and Exercise Therapy on the Rehabilitation of the Arm of Hemiparetic People After Stroke in the Chronic Phase	Recruiting	Intervention	2019-07-18	<NULL>	<NULL>	2825	Effect of Robotic Therapy and of Kinesiotherapy on the Rehabilitation of the Upper Limb of Hemiparetic Individuals After Stroke in the Chronic Phase	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-27	Universidade Metodista de Piracicaba - Programa de Pós Graduação em Ciências do Movimento Humano	Universidade Metodista de Piracicaba - Programa de Pós Graduação em Ciências do Movimento Humano	https://ensaiosclinicos.gov.br/rg/RBR-2pcvt4	<NULL>	Age between 18 and 80 years; single episode of ischemic vascular brain lesion for at least 6 months; upper limb motor impairment graded by the Fugl Meyer Scale, with a score of 7 for upper limb; degree of spasticity less or iqual  3 as measured by Modified Ashworth scale in the brachial biceps muscle; no range of motion limitation greater than 10 degrees of elbow extension and 10 degrees of extension of the wrist, assessed by goniometer; is not included or has participated in a robotic therapy program; have not received botulinum toxin or other types of anti-spastic drugs in the last three months.	Aphasias and agnosias that preclude the understanding of the virtual tasks proposed for the intervention; subluxation of the shoulder (anterior and / or inferior) evaluated clinically by palpation (bigger than 2 cm); presence of severe pain in the movement of the shoulder, elbow or wrist.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-6jzsxns	Effect of root canal enlargement on cleaning, postoperative pain, and outcome of root canal treatment	Recruiting	Intervention	2021-05-14	<NULL>	<NULL>	4652	Effect of final instrumentation diameter on root canal disinfection, postoperative pain and outcome of endodontic treatment: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-02	Universidade Federal de Pelotas - Faculdade de Odontologia	Universidade Federal de Pelotas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-6jzsxns	<NULL>	Health individuals; both genders; 18 years old and up; presenting lower molars referred to endodontic treatment; with apical periodontitis	Root fractures; endo-periodontal resorptions; envolving furcal area; systemic diseases which compromise bone metabolism; endodontic retreatment cases; mobility grade I or higher; periodontal disease; pregnant women; antibiotics within the last 30 days or anti-inflammatory drugs and analgesics within the last 72 hours; non-controled diabetic patients; immuno compromised patients; acute apical abscess; teeth presenting severe curvatures; or atypical anatomic charactheristics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:31
RBR-6268zz	Effect of root planning in microbiological, White blood cells, immunoglobulins and pro and anti inflamatory cytokines dosage in blood and saliva from periodontitis and type 2 diabet persons	Recruitment completed	Intervention	2016-03-05	<NULL>	<NULL>	3224	Effect of mechanical periodontal therapy in microbiological, imunocelular, immunoglobulins and pro and anti inflamatory cytokines dosage in periferal blood and saliva from type 2 diabet persons	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-20	Universidade de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6268zz	<NULL>	Minimum of 15 teeth; least 30 percent of the sites with periodontal probing depth greater than or equal to 4 mm; at least two teeth with greater insertion loss than 3 mm; Age greater than or equal to 30 years. The control group will consist of individuals aged greater than or equal to 30 years; systemically healthy; Clinical and radiographic periodontal health; Minimum 20 teeth with less clinical probing depth or equal to 3 mm; lower insertion level at 3 mm; less than 10% of sites with bleeding on probing	Periodontal treatment in the last six months; Continued use of medications such as antibiotics, immunomodulators or anti-inflammatory drugs in the last three months; Systemic diseases that interfere with periodontal condition, except for diabetes for the test group (HIV, immune disorders, morbid obesity (BMI 40 kg / m2) or underweight (BMI less malnourished 18.5 kg / m2), etc.) ; Pregnant or lactating; smoking; Under age 30; Indigenous groups	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-88hrnnw	Effect of Rosemary on sleep, mood status and cardiovascular risk in emergency nursing: intervention study	Not yet recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5635	Effectiveness of Rosemary on sleep, affectivity and cardiovascular risk in emergency nursing: a quasi-experimental study	<NULL>	2-3, n/a, open	2-3	<NULL>	<NULL>	<NULL>	2022-10-03	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-88hrnnw	<NULL>	Nursing assistants; nursing technicians; nurses; work in emergency services (emergency care unit and hospital emergency department) for at least one month; aged 30 years or older; under any form of contract	Hypersensitivity to Rosemary; pregnant women; lactating women; epileptics; dyslipidemia treatment; diabetes mellitus treatment; biliary or hepatic dysfunction; prostatic diseases; gastroenteritis; those with hair &lt; 2 cm in the region of the posterior vortex of the head; use of topical medication on the scalp; or away from work for any reason during the data collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-1022mp73	Effect of RTA on the Removal of Airway Sections of Premature Infants on Mechanical Ventilation	Recruitment completed	Intervention	2021-05-28	<NULL>	<NULL>	4688	Effectiveness of the Thoracoabdominal rebalancing method in the removal of airway sections and their repercussions in mechanically ventilated preterm infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-03	Universidade Federal do Rio grande do Norte/Maternidade Escola Januário Cicco	Universidade Federal do Rio grande do Norte/Maternidade Escola Januário Cicco	https://ensaiosclinicos.gov.br/rg/RBR-1022mp73	<NULL>	Preterm newborns of both sexes; corrected gestational age less than 37 weeks; age over 72 hours of life; no contraindications to respiratory physiotherapy; have the free and informed consent of the parent or legal guardian; use invasive ventilatory support for orotracheal cannula with ventilation period longer than 48 hours; present clinical or radiological evidence of pulmonary secretion.	Hemodynamic instability; carriers of congenital and cardiac malformations; complication or complications during collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-8hz5v5	Effect of scalp acupuncture in patients with chronic stoke - randomized clinical trial	Recruiting	Intervention	2019-06-17	<NULL>	<NULL>	2767	Effect of scalp acupuncture on cortical electrical activity in patients with stroke - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-25	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8hz5v5	<NULL>	Both genders; age above 30 years; sepsis of spastic hemiparesis; degree of moderate motor impairment as assessed by the Fulg Meyer scale; perform computed tomography to determine the area of the injury and clinical diagnosis; good cognitive ability; injury time over 3 months; sensory impairment assessed by the Fulg Meyer scale.	Hemiparesis due to another disease; cognitive impairment; neoplastic disease; bilateral motor and sensory sequel; hemorrhagic stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-7qnxty	Effect of Self Massage on muscle strength in female soccer athletes	Data analysis completed	Intervention	2020-03-12	<NULL>	<NULL>	3612	Effect of Self-Myofascial Release on muscle strength in female soccer athletes: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Samuel Miranda Souza	Universidade Católica do Salvador	https://ensaiosclinicos.gov.br/rg/RBR-7qnxty	<NULL>	Being a female soccer athlete at Esporte Clube Vitória	Athletes who were in the process of recovering from lower limb injuries; athletes who underwent surgery in the last eight months prior to the collection period; athletes who presented some condition that would make them unable to perform the practices.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-69hwsrt	Effect of Self the Care stimulation on family caregivers of patients in a home care program	Suspended	Intervention	2021-12-22	<NULL>	<NULL>	5125	Effect of the Inciting Self the Care intervention on family caregivers of patients linked to a home care program: a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-69hwsrt	<NULL>	Primary family caregiver of a patient with a chronic condition treated by the Home Care Program; resident in Pelotas in Rio Grande do Sul; age greater than or equal to 18 years; minimum dedication of 12 hours a day to care; literate; communication in Portuguese.	Not being available to receive the care interventions; death of the person with chronic disease in care; have someone resident of the domicile with a positive result for coronavirus during the data collection period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-2y8f8r	Effect of Self-chosen Intensity of Aerobic Exercise on continuity and pleasure in practice, and factors associated with the health of adolescents with Obesity	Recruitment completed	Intervention	2018-02-05	<NULL>	<NULL>	2815	Effect of Self-selected Intensity of Aerobic Exercise on adherence, affective responses and factors associated with physical and mental health of adolescents with Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Federal Institute of Sertão Pernambucano	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2y8f8r	<NULL>	Adolescents should be classified as obese according to criteria of the Centers for Disease Control and Prevention (CDC, 2000) (BMI&gt; P95th); with pubertal maturational stage (stages 3 and 4) according to criteria established by Tanner (1976); considered fit to participate in a program of 12 weeks of physical exercises after cardiological evaluation (resting electrocardiogram).	Individuals who present self-reported genetic; metabolic; endocrine diseases; report chronic alcohol consumption; prior drug use; pregnancy during the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-6pf78g	Effect of selfintention practice on eating behaviour, body measures and body image in overweight women	Data analysis completed	Intervention	2020-08-18	<NULL>	<NULL>	4136	The impact of self-intention on food intake, anthropometry and body image of overweight women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-10	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6pf78g	<NULL>	Women with BMI &gt; 25Kg/m²; have access on internet; have smartphone with WhatsApp	Be in treatment for weight loss in the last three months, whether by use of medications or diets; have a BMI of less than 25 kg/m²; being in use of hormone replacement therapy; presenting some physical deficiency that prevents the accomplishment of the anthropometric measures; presenting some level of cognitive deficit that prevents the eating record register	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-75rsy6w	Effect of Sensory Stimulation on the foot on the mobility, capacity and physical performance of people with Parkinson&apos;s disease	Recruiting	Intervention	2025-04-14	<NULL>	<NULL>	7913	Effect of Hallux Sensory Stimulation on Mobility, Capacity and Performance Functional Performance of people with Parkinson&apos;s Disease: a clinical trial, double blind, randomized and crossed	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Estadual Paulista	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-75rsy6w	<NULL>	Motor limitations caused by Parkinson&apos;s disease, classified as moderate to severe (score 2.5 to 4 on the Hoehn and Yahr scale) and gait impairment characterized by reduced walking speed (speed less than 1.0 m.s-1). Participants whose drug treatment for Parkinson&apos;s disease remains unchanged for at least 30 days before the start of and during the volunteer&apos;s participation in the study. Participants must also be on drug treatment for Parkinson&apos;s disease for at least six months. Minimum age of 60 years. Both sexes	Signs of severe cognitive decline, based on the results of the Mini-Mental State Examination, adjusted according to the educational level for the Brazilian population. Presenting cardiorespiratory, neuromuscular and musculoskeletal diseases, which are not related to Parkinson&apos;s disease, and which make it impossible to carry out tasks security testing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-39szpm6	Effect of several pre-exercise interventions on physical performance	Data analysis completed	Intervention	2024-05-27	<NULL>	<NULL>	7028	Different pre-exercise strategies on physical performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-03	Instituto de Ciências Biológicas da Universidade Federal de Juiz de Fora	Instituto de Ciências Biológicas da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-39szpm6	<NULL>	Healthy subjects; Age between 18 and 40 years old; male; experience with resistance exercise of at least one year	Smoking history; presence of any metabolic or cardiovascular disease; arterial hypertension (≥140/90 mmHg or use of antihypertensive medications); use of anabolic steroids, drugs or medications with potential impact on physical performance; recent musculoskeletal injury; previous experience with pneumatic occlusion intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-6hn5nnr	Effect of sexual counseling on sexual function and quality of life of pregnant women	Recruiting	Intervention	2023-10-23	<NULL>	<NULL>	6530	Effect of the Pilset model on the sexual function and sexual quality of life of pregnant women: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-03	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6hn5nnr	<NULL>	Pregnant women monitored by Family Health teams (eSF) during the data collection period; with a sexual partner; age between 20 and 35 years; who are at most 18 weeks gestational on the day of the first intervention	Women accompanied by high-risk prenatal care, whose pregnancy resulted from sexual violence or who experience violence by an intimate partner; who present psychic alteration in the use of medications (selective serotonin reuptake inhibitors, antipsychotics, antiepileptics, anxiolytics, antidepressants and hypotensives) because they affect the female sexual response (FEBRASGO, 2017); dropouts after starting data collection; reclassification as a high-risk pregnant woman (BRASIL, 2012); missing two or more sessions of the educational intervention; if during the intervention or data collection period the woman gives birth; come to death or miscarriage; or the pregnant woman changes her address in a way that changes the link to the Basic Health Unit (UBS)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-82tv5q	Effect of simulation in the nursing student&apos;s knowledge	Recruitment completed	Intervention	2016-05-28	<NULL>	<NULL>	2850	Effect of simulation in the nursing student&apos;s knowledge about cardiopulmonary resuscitation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Federal do Rio de Janeiro	Fundação Educacional de Macaé	https://ensaiosclinicos.gov.br/rg/RBR-82tv5q	<NULL>	Second or third year degree in Nursing; to have 18 years old or more, have not had prior contact with courses or first aid and emergency training.	Technical training in nursing; Professional role as technician or nursing assistant; having first aid training; participate in research projects or extension that deal with the subject.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-6r876vt	Effect of simulation versus lecture on surface cleaning and disinfection: a quasi-experimental study	Other	Intervention	2026-04-27	<NULL>	<NULL>	9143	Effect of simulation training and interactive lecture-based teaching on the surface cleaning and disinfection process	<NULL>	n/a, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Mato Grosso do Sul	<NULL>	<NULL>	<NULL>	Nursing and cleaning professionals actively and directly involved in the cleaning and disinfection process at the medical clinic unit during the study period; professionals of both genders; professionals aged 18 years or older; professionals working on a 12 by 36-hour shift schedule (twelve hours of work followed by thirty-six hours of rest), covering both even and odd shifts	Professionals who are not directly responsible for the cleaning and disinfection process due to being in managerial or administrative roles; interns and students from technical or undergraduate courses	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-523n7r	Effect of simvastatin 20mg in bone formation after Removal of lower third molar teeth	Data analysis completed	Intervention	2020-02-20	<NULL>	<NULL>	3519	Efficacy of simvastatin 20mg on bone regeneration after lower third molar extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-08	Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco - UPE	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-523n7r	<NULL>	The inclusion criteria were as follows: adult patients aged between 18-40 years old, of both genres, of any ethnicity, healthy, without allergy to the drugs used in the research or its components and who are not using any other medication. All patients must have both lower third molars, included, with the same inclusion pattern according to the Pell &amp; Gregory classification, healthy, with indication of extraction and without signs of pericoronitis or inflammation.	The exclusion criteria were: patients with an inability to open their mouth for surgery; exceed 40 minutes in any surgery; fracture or postoperative infection; recent history of chemotherapy and / or radiation to the head and neck; giving up participating in the research at some point; make use of medications that have a known interaction with any drugs used in the study; smokers, pregnant or lactating women; did not perform the tests requested in the postoperative period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-7nynr7	Effect of skin-to-skin compared to the sweet solution for pain relief in newborns who require repeated blood collection.	Recruiting	Intervention	2014-05-28	<NULL>	<NULL>	297	"Effect of skin-to-skin compared to sucrose for pain relief in infants undergoing repeated painful procedures:
randomized clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-06-06	Escola de Enfermagem de Ribeirão Preto-USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto-Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7nynr7	<NULL>	Inclusion criteria: infants with gestational age greater than or equal to 36 weeks, which present Apgar score&gt; 7 at 5 minutes and clinical stability with maintaining physiological parameters in the normal range, ie, heart rate between 120 to 160 beats per minute (bpm). Mothers whose children are randomly assigned as skin to skin contact should be in physical and emotional conditions to breastfeed.	Exclusion criteria: infants who had birth trauma (fractures, skin lesions, soft tissue injuries cortocontusos, adiponecrose, bleeding from the sternocleidomastoid, brachial palsy, facial paresis, trauma of the sternocleidomastoid, intracranial hemorrhage, visceral rupture, bilateral paralysis of vocal cords, brachial palsy, facial palsy, spinal trauma and spinal cord and diaphragm paralysis), congenital malformations, difficulty swallowing, use of opioids in preterm and/or the mother less than six hours, presence of severe intraventricular hemorrhage or subsequent periventricular and contraindications of breastfeeding .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-6rkz85	Effect of sleep duration on performance-deficient, visually impaired athletes, physical performance, and hormones related to sleep, melatonin, and cortisol	Recruiting	Intervention	2019-10-16	<NULL>	<NULL>	3093	Effect of sleep duration on high performance poor visually impaired athletes, on physical performance and hormonal responses	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Capes	Fundo de apoio ao ensino, à pesquisa e extensão - Faepex	https://ensaiosclinicos.gov.br/rg/RBR-6rkz85	<NULL>	"For the data collection will be selected 12 Brazilian high performance athletes,
(B1, B2, B3), who participate in national competitions
Box and Brazilian Championships) and international of the modality swimming.
Regardless of age and gender."	"Athletes who make continuous use of
control sleep and depression. Also excluded are those that are in the depression."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-3dznfh	Effect of social media on oral hygiene habits in children	Recruitment completed	Intervention	2018-07-11	<NULL>	<NULL>	1992	Impact of social media on oral hygiene habits in children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3dznfh	<NULL>	Guardians that authorized the participation of the scholar in the study through the signing of the Free and Informed Consent Form; scholars who signed the Consent Form and that were enrolled in the sixth to the ninth grade in the School of Application of UFSC; scholars who used fluoride toothpaste and had a Smartphone with the WhatsApp Application	Dental caries with repercussions in the pulp; scholars with orthodontic devices; with systemic diseases; and with learning disabilities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-4s8qjx	Effect of soft silicone foam dressing compared to film transparent dressing in Pressure Ulcer prevention	Recruitment completed	Intervention	2017-08-31	<NULL>	<NULL>	2668	Randomized clinical trial about multilayered soft silicone foam dressing to transparent polyurethane film Effectiveness in Pressure Ulcer prevention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-22	Universidade Federal de Santa Maria - UFSM	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-4s8qjx	<NULL>	over 18 years old; high risk and very high risk for developing pressure ulcer from the Braden scale; has been evaluated by the researcher within 24 hours of hospitalization; show the heels pair healthy	allergy to the research product; being pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-53tx8f	Effect of specialized attention directed to health education in the construction of knowledge about diabetes mellitus	Recruitment completed	Intervention	2020-04-07	<NULL>	<NULL>	3714	Effect of specialized attention directed to health education in the construction of knowledge about diabetes mellitus: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-53tx8f	<NULL>	Ages 18 years and over, of both sexes; Have a previous diagnosis of type 1 or 2 diabetes mellitus; Being out of balance with your staff in the last year; Be able to perform self-care; Accept to participate in the research by signing the consent form.	Loss of autonomy and independence to perform self-care during the research period; Unjustified absence of one of the intervention activities; Disconnection of CEAE; Individuals who do not agree to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-337hq7s	Effect of Specific and Non-Specific Exercises on pain in patients with Chronic Neck Pain	Not yet recruiting	Intervention	2023-05-31	<NULL>	<NULL>	6125	Effect of Specific and Non-Specific Exercises on pain processing in individuals with Chronic Neck Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-10	Universidade Federal de São Carlos - UFSCar	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-337hq7s	<NULL>	Age between eighteen and sixty-five years; both sexes; neck pain lasting three months or longer, non-specific (no known causes), with or without irradiation; presence of pain at rest and/or during active cervical movements with a score greater than or equal to three on the Numerical Pain Scale; and score greater than or equal to ten on the Neck Disability Index	Signs of radiculopathy in the upper limbs (loss of muscle strength in the myotome, sensory loss in the dermatomes and/or changes in reflexes); whiplash-associated disorder; cervicogenic headache; fibromyalgia; pregnancy; history of trauma; cervical fractures or surgeries; cervical-related rheumatic inflammatory diseases; neurological; tumors and/or medical contraindication to practice physical exercise; physiotherapy or cervical infiltration in the last three months; starting some physical activity in the last two weeks; use of analgesics, use of anti-inflammatories or muscle relaxants in the twenty-four hours prior to the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-62kz97v	Effect of specific Exercise with orthopedic Brace combined customized Insole in adolescents with Idiopathic Scoliosis	Not yet recruiting	Intervention	2025-10-21	<NULL>	<NULL>	8430	Therapeutic effect of specific Exercise and use of orthopedic Brace combined with 3D customized Insole in adolescents with Idiopathic Scoliosis: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-31	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	https://ensaiosclinicos.gov.br/rg/RBR-62kz97v	<NULL>	Adolescents aged 11 to 18 years; diagnosis of adolescent idiopathic scoliosis; both genders	Symptomatic musculoskeletal diseases in the lower limbs; symptomatic diseases of the central and peripheral nervous system; diabetes mellitus; corrective surgery for spinal curvature; rigid foot deformities; injections in the feet and ankles in the last three months; previous or planned spinal surgery in the next twelve months; and mental disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-3h6nkn	Effect of Speech Therapy on snoring in obese patients	Not yet recruiting	Intervention	2020-02-28	<NULL>	<NULL>	3539	Effect of Orofacial Myofunctional Therapy on the room of obese patients: ramdomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Estadual do Oeste do Paraná - Campus Cascavel	Universidade Estadual do Oeste do Paraná - Campus Cascavel	https://ensaiosclinicos.gov.br/rg/RBR-3h6nkn	<NULL>	Minimum age of 18 years; have a smartphone; accept sleeping in a room separate from the partner; agree to participate in the research by signing the Free and Informed Consent Form.	Non-availability to do the treatment for the established period; benzodiazepine medication users; continuous users of muscle relaxants; alcoholics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-6tkt5xm	Effect of speech therapy treatment before orthognathic surgery to improve the muscles of the lips, tongue and cheeks, breathing, chewing, swallowing and speech	Recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8913	Effectiveness of speech therapy in the preoperative phase of orthognathic surgery	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Centro de Ciencias da Saúde	<NULL>	<NULL>	<NULL>	"Men and women between the ages of 18 and 50 who will undergo maxillary and/or mandibular osteotomy for dentofacial correction; Individuals who do not have skin conditions and/or who can discontinue the use of facial acids and who have not used Roaccutane in the last 6 months;
Individuals who are not currently using facial acid treatments; Individuals without craniofacial anomalies; Without cognitive deficits; Who are not allergic to the elastic bandage material"	Patients undergoing physical therapy during the postoperative period; Patients who experienced surgical complications and required special care; Patients who were unable to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-42pbbqq	Effect of Spinning Babies® techniques on labor duration and cesarean section rates	Recruiting	Intervention	2025-08-28	<NULL>	<NULL>	8235	Effect of Spinning babies® on labor progression and cesarean delivery rates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-05	Universidade Federal de Santa Catarina	hospital de clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-42pbbqq	<NULL>	Pregnant women aged 18 years or older; Pregnancy with a gestational age of 37 weeks or more;Singleton pregnancy with the fetus in a cephalic presentation; Nulliparous pregnant women with intact or ruptured amniotic membranes in spontaneous labor; Pregnant women with the fetus in the mid-pelvic plane, i.e., at De Lee stations -1, 0, or +1.	Pregnant women with a history of practicing Spinning Babies® within the last 24 hours; pregnant women who have undergone any type of pharmacological induction; pregnant women with any communication or comprehension barriers regarding the Portuguese language; pregnant women with physical limitations or contraindications that prevent them from performing Spinning Babies® exercises; and pregnant women accompanied by doulas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-794zhy	Effect of squatting posture on low back pain in adolescents and young adults	Data analysis completed	Intervention	2018-11-09	<NULL>	<NULL>	2328	Effect of squatting posture on the improvement of myofascial low back pain and body alignment in adolescents and young adults	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-06	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-794zhy	<NULL>	volunteers with chronic myofascial low back pain; age between 15 e 25 years; male and female	obese; pregnant women; wheelchair users; musculoskeletal disorders in the lower limbs; pelvic girdle and spine, such as fractures; trauma; surgery; scoliosis and kyphoscoliosis; congenital deformities in the lower limbs and spine; neurological diseases; individuals with cognitive deficits and performing physiotherapy treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-10bk2qbb	Effect of stem cells in patients with flaccid bladder	Recruitment completed	Intervention	2021-05-27	<NULL>	<NULL>	4680	Effect of Autogenous Mesenquimal Stem Cells on Patients with muscular dysfunction: Hypocontractility	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-10bk2qbb	<NULL>	The inclusion criteria will be male and female patients with a urodynamic study showing only detrusor hypocontractility, without the presence of an obstructive factor to the urinary flow. They must be in clean intermittent catheterization, not undergoing any surgical procedure in the lower urinary tract in the last 12 months.	Exclusion criteria: end-stage renal failure (with oligo-anuria), recurrent urinary tract infection, non-adherence to clinical monitoring protocols and clean intermittent auto-catheterization. Presence of any malignant neoplasm confirmed in treatment or recently treated or even any suspicion of cancer will be an important exclusion criterion due to contraindication to the use of stem cells in these patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-8xttkv	Effect of stimulation of the senses in the head control in children with cerebral palsy	Recruiting	Intervention	2016-07-20	<NULL>	<NULL>	932	Influence of sensory stimulation in the head control in children with cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Educação Física/ Universidade de Brasília	Hospital da Criança de Brasília José Alencar	https://ensaiosclinicos.gov.br/rg/RBR-8xttkv	<NULL>	Children diagnosed with cerebral palsy classified V level Gross Motor Functional Classification System - GMFCS, aged 9 and 36 months.	1) Children who completed 36 months before the final evaluation; 2) associated syndromes; 3) seizures outside clinical control; 4) structural musculoskeletal deformities preventing the execution of motor intervention; 5) Total visual impairment; 6) hearing loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-22vxvq	Effect of stimulation with electrical current associated with exercise in stroke: randomized controlled clinical trial	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1034	Effect of interferential current associated with exercise in stroke: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-31	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-22vxvq	<NULL>	Patients with stroke in mild or moderate spastic phase, both genders, aged 30 to 70 years and without physical therapy concomitant during the training period.	Patients who present score less than 24 on the Mini-mental exam, psychiatric condition, cognitive decline or dementia influencing the communication process, musculoskeletal, neuromuscular, or recent cardiopulmonary disorder, patients who can not walk and sit independently, present anesthesia in the trunk region or refuse to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-3rqmgh	Effect of stimulation with electrical current in fibromyalgia:randomized clinical trial	Recruiting	Intervention	2015-03-17	<NULL>	<NULL>	421	Effect of TENS in fibromyalgia:randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-17	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3rqmgh	<NULL>	Will be included patients with fibromyalgia, diagnosed according to the criteria of the American College of Rheumatology, female, aged 18 to 60 years, without physical therapy concomitant.	Subjects will be excluded if they have concomitant rheumatologic disease, severe psychiatric disorders or any contraindication to prevent the use of the IC, such as allergies to the electrodes, cardiac pacemaker, pregnancy, epilepsy, skin conditions or deficient skin sensation in the areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-8yy2bg	Effect of street running on weight loss for people with Overweight and Obesity	Not yet recruiting	Intervention	2020-02-12	<NULL>	<NULL>	3480	Effect of a sports training level running program on the body composition of Overweight and Obesity adults	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8yy2bg	<NULL>	Men and women, aged between 20 and 45 years, with overweight / obese (BMI between 25kg / m² and 34.9kg / m2) (WHO, 2015), previously sedentary for at least three months prior to study enrollment (no physical exercise for at least 10 continuous minutes / week ), have not changed more than 3 kg of body mass in the last 3 months, non-smokers, non-users of supplements and medications that influence body mass, no history of cardiovascular, respiratory, metabolic or musculoskeletal disease affecting the ability to participate in training programs, women are not menopausal or are not in the period of climacteric, moreover, were considered fit in the physical evaluation done immediately before the study.	People who start drug treatment, supplementation or diet and / or start another physical exercise during the intervention period and if they have orthopedic conditions that affect their ability to continue participating in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-8gfv5j	Effect of strength exercises of muscles neck in peoples with migraine and without migraine	Recruitment completed	Intervention	2016-11-28	<NULL>	<NULL>	4800	Neck-specific strengthening exercise compared with placebo sham ultrasound in patients with migraine: two-armed, parallel-groups randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8gfv5j	<NULL>	Volunteers with migraine; both genders; aged between 18 and 55 years.	Diagnosis of other headache; analgesic abuse; history of trauma in the neck or face; pregnancy; hernia diagnosis or disc degeneration in the cervical; systemic diseases, anesthetic block in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-78bn3gf	Effect of Strength Training and Miconia Albicans on Pain, Inflammation and Functionality in women with knee Osteoarthritis	Not yet recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7772	Effect of Resistance Training and Miconia Albicans on Pain, Inflammation and Functionality in women with knee Osteoarthritis: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-78bn3gf	<NULL>	Female subjects with radiographs showing knee osteoarthritis grades II and III on the Kellgren and Lawrence osteoarthritis classification. Knee pain greater than 3 on the numerical pain rating scale. Age 50 to 70 years and functional impairment in the past 3 months that met at least one of the American College of Rheumatology classification criteria	Female individuals with neurological, cardiovascular and/or pulmonary diseases that may compromise the execution of the exercise protocol. Have used intra-articular injections of steroids or other substances in the last three months. Have systemic inflammatory disease. Have had orthopedic surgery on the lower limbs or are unable to perform the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-3fg9cd	Effect of Strength Training associated with muscular electric current on the structure and function of knee extensor muscles	Data analysis completed	Intervention	2017-11-23	<NULL>	<NULL>	1497	Effect of Strength Training associated with Neuromuscular Electrical Stimulation on a structure and function of knee extensor muscles	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-09	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3fg9cd	<NULL>	Undergraduate and graduate students; healthy; aged between 18 and 35 years.	Volunteers with the presence of any health condition that contraindicates or impairs the performance of high intensity exercises; history of knee surgery; a recent picture of musculoskeletal injuries in the lower limbs; subjects engaged in systematic training programs during the collection period; subjects engaged in lower limb strength training programs within 3 months prior to the study; users of ergogenic supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-47274gx	Effect of strength training combined with physiotherapeutic exercises on muscle recovery and rehabilitation in athletes and active adults: an evaluation of the heart, muscle, and blood: a randomized placebo-controlled trial	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7754	Effect of strength training combined with different therapeutic modalities on musculoskeletal mecovery and rehabilitation in athletes and recreationally active adults: an integrated approach to cardiovascular, autonomic, neuromuscular, and blood responses: a randomized placebo-controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-47274gx	<NULL>	Perform at least 300 minutes of physical activity per week. Be between 18 and 59 years old. Both sexes. Be free from functional limitations that prevent the tests and/or the proposed protocol from being performed.	Consuming caffeine-based ergogenic aids. Reporting any type of acute dizziness. Presenting abnormal fluid accumulation (edema), especially in the lower limbs. Presenting impairments in the basilar artery that make cervical manipulations impossible. Diagnoses that affect postural control, such as vestibular dysfunction, Alzheimer&apos;s disease, Parkinson&apos;s disease, or motor neuron disorders. History of lower limb trauma in the last year. Presence of severe cardiopulmonary disease. Participants currently involved in a structured exercise program focused on postural control.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-38nkj6	Effect of strength training in older depressed	Data analysis completed	Intervention	2014-06-10	<NULL>	<NULL>	302	Effect of strength training in older depressed	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Instituto de Neurologia Deolindo Couto	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-38nkj6	<NULL>	Right-handed; sedentary for more than three months; performing more than one month pharmacological treatment; clinical diagnosis using the criteria of the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).	Score over 18 points on the Hamilton Depression Scale; Score under 24 points in the Mini - Mental State Examination; Psychiatric comorbidities; neurodegenerative disease; severe cardiovascular disease; illiteracy; poor mobility; balance disorders; visual and / or auditory sharp.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-48c29w	Effect of strength training in the vascular function of hypertensive elderly	Data analysis completed	Intervention	2016-02-01	<NULL>	<NULL>	707	Effect of strength training in the vasodilatory response of hypertensive elderly: related mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-48c29w	<NULL>	Aged between 65 and 75 years; have not committed any type of regular exercise (more than 2 days per week) over a period of 6 months prior to study entry; have mild essential hypertension (stage I).	Have history or evidence of hematologic disease; peripheral vascular disease; stroke; obesity; diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-7xmh8d	Effect of strength training on body composition, biochemical markers and quality of life in patients with chronic kidney disease	Recruitment completed	Intervention	2020-03-26	<NULL>	<NULL>	3667	Effect of strength training in patients with chronic kidney disease	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-08	Universidade do estado do rio grande do norte	Universidade do estado do rio grande do norte	https://ensaiosclinicos.gov.br/rg/RBR-7xmh8d	<NULL>	Patients of both sexes aged 18 to 65 years, undergoing HD treatment with a minimum time of three months, with vascular access by arteriovenous fistula, with independent ambulation. All participants responded to an anamnesis prior to study initiation.	Patients who were engaged in an exercise program, with physical disability and musculoskeletal limitations that precluded assessments and exercise protocol, with a history of heart attack in the last six months, with recent hospitalization history (&lt;3 months), decompensated diabetes and blood pressure, pregnant , pacemaker users and with less than 70% attendance of training sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-8xjjqy	Effect of Strength Training on Neuromuscular Adaptations in Older Women and Youth	Recruitment completed	Intervention	2019-11-22	<NULL>	<NULL>	3213	The Trainability of Neuromuscular Adaptations of Older Women and Youth	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-08	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-8xjjqy	<NULL>	"Seniors aged 60 to 82 years;
Elderly women who were only practicing the Prev Quedas project gymnastics;
Elderly women who independently maintained their daily activities, verified through Baecke&apos;s Modified Questionnaire;
Only those who presented medical examination authorizing the practice of strength exercises participated;
Elderly women who obtained a completed application form in the Prev Quedas project."	"Elderly women with clinical conditions that represented an impediment to performing the proposed exercises, or associated with increased health risks (for example: blindness, limb amputations, diseases of the following types: degenerative, osteomioarticular, metabolic, renal, severe heart disease: angina, coronary heart disease, uncontrolled hypertension, arrhythmias, valvular disease, and heart failure; difficulty in maintaining the standing position or use of orthosis to aid gait; and cancer);
Elderly women with spinal problems with medical restriction;
Those who underwent surgery and / or hospitalization in the last 12 months;
Older women with low educational level;
Elderly women who used 5 (five) or more medications;
Those who participated in a bodybuilding program in the last 12 months;
Older women with a history of falling in the last 12 months;
Elderly women with low cognitive ability verified through the Mini Mental State Examination;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-3d7yy4	Effect of Strength Training on the activation Myoelectric Respiratory, Structure Diaphragmatic, Pulmonary Function and Quality of Life in individuals with Heart Failure	Recruiting	Intervention	2016-09-22	<NULL>	<NULL>	1015	Effect of Strength Training on the Activation Myoelectric Respiratory, Structure Diaphragmatic, Pulmonary Function and Quality of Life in individuals with Heart Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3d7yy4	<NULL>	Patients must have a diagnosis of heart failure for at least six months; not have been admitted in two months; diagnosed as functional classes I, II, III, Second NYHA; left ventricular ejection fraction at rest &lt;45% rated by the echocardiogram; hemodynamic stability for at least two months; medication with optimal doses for at least two months; Body mass index (18.5 to 29.9 kg / m²); not present clinical history indicative of respiratory disease	Patients with worsening exercise tolerance or HF symptoms during the last 3-5 days; incapacidade de compreender ou realizar os exercícios; increase in body weight within 24 hours more than one kilogram; significant exercise-induced ischemia; present atrial fibrillation; decreased blood pressure&gt; 20 mmHg during exercise; Systolic pressure at rest&gt; 160 mmHg and diastolic&gt; 90 mmHg; Complex arrhythmias at rest or arrhythmias that develops with exercise; third-degree atrioventricular block; Resting heart rate&gt; 100 bpm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-6kfptkj	Effect of Strength Training with Blood Flow Restriction on Arterial Occlusion Pressure, Body Composition, Muscle Strength and Localized Muscle Endurance	Not yet recruiting	Intervention	2021-08-09	<NULL>	<NULL>	4821	Effect of Strength Training with Blood Flow Restriction: Physiological, Morphological and Neuromuscular Adaptations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-06	Universidade Federal da Paraíba (UFPB)	Universidade Federal da Paraíba (UFPB)	https://ensaiosclinicos.gov.br/rg/RBR-6kfptkj	<NULL>	be between 18 and 30 years old; have no history of cardiovascular or pulmonary diseases; Ankle Brachial Index (ABI) between 0.91 and 1.30; Body Mass Index - normal BMI (≥18.5 and &lt;24.9 kg / m2); answer negatively to all items of the Physical Activity Readiness Questionnaire / PAR-Q	subjects who present any cardiovascular aggravation during the experiment; musculoskeletal or drop out of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-655vxdd	Effect of Strength, Aerobic and Concurrent Training on memory, musculature and intestinal health in the elderly	Not yet recruiting	Intervention	2023-10-11	<NULL>	<NULL>	6498	Effect of Strength, Aerobic and Concurrent Training on cognitive, neuromuscular parameters and the microbiota-intestine-brain axis in elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-655vxdd	<NULL>	Age over 60 years. Elderly men and women. Body mass index below 30. Present physical conditions to carry out the exercise protocol. Have not been performing any regular physical activity for at least three months. Without a history of practice competitive sports throughout life. Achieve a score equal to or greater than 24 on the Mini-Mental State Examination. Achieve a score of up to 9.11 on the Baecke Physical Activity Questionnaire, the cut-off point adopted for low intensity of daily physical activity	"Use of antidepressants, antiepileptics, anticonvulsants, psychoactive drugs or other medications that act on the Nervous System. In use of antimicrobials for 30 days. In use of chemotherapy/immunotherapeutics
In use of probiotics. In use of metformin and or proton pump inhibitor. On enteral diet. Recently hospitalized for 30 days. Acute or chronic bowel conditions (diarrhea, inflammatory bowel disease, Irritable Bowel Syndrome). Bariatric disease. Chronic diseases (diabetes). Cancer. Rheumatological diseases. Neurodegenerative diseases. Autoimmune diseases"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-9dsnjq8	Effect of Strengthening Exercises on the force transmission between the latissimus dorsi and the gluteus maximos	Not yet recruiting	Intervention	2022-12-07	<NULL>	<NULL>	5759	Evaluation of the effect of Resistance Training on myofascial force transmission between latissimus dorsi and gluteus maximus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9dsnjq8	<NULL>	Healthy volunteers; both genders; aged between 18 and 35 years; body mass index (BMI) less than or equal to 27 kg/m²; at least 25º of passive medial and lateral hip rotation without pain	Individuals who have practiced physical activity in the last three months; musculoskeletal injury or current or recent symptoms (6 months) in the assessed regions; inability to keep Latissimus Dorsi, paraspinal and hip muscles relaxed during the assessment; pain or discomfort during data collection or intervention and that makes it impossible for them to remain in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-942kk6s	Effect of strengthening the inspiratory muscles in patients after cardiac surgery	Data analysis completed	Intervention	2023-07-04	<NULL>	<NULL>	6200	Inspiratory muscle training in the postoperative period of cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Medicina do ABC	Hospital do Coração do Cariri - HCC	https://ensaiosclinicos.gov.br/rg/RBR-942kk6s	<NULL>	Patients in the postoperative period of elective cardiac surgery via sternotomy and using cardiopulmonary bypass; left ventricular ejection fraction above 40%; body mass index lower than 30 kg/m2.	Patients who required additional surgery during the postoperative period; as well as those who had complications such as cardiorespiratory arrest;  prolonged sedation; mechanical ventilation time greater than twenty-four hours;  neurological complications; patients who could not understand or collaborate with the procedures were also excluded since the conducts applied in the  inspiratory muscle training are volitional.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-46wwj7	Effect of Stretching at different intensities on Neuromuscular Responses in adults and the elderly.	Suspended	Intervention	2017-11-21	<NULL>	<NULL>	1489	Effect of Stretching intensity on acute and chronic Neuromuscular Responses in adults and the elderly: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade de Pernambuco	Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-46wwj7	<NULL>	Young adults between 18 and 30 years of age; aged between 60 and 70 years; male; being able to practice physical activity (identified through PAR-Q); have no history of surgery, fracture and arthritis in the lower limbs; have an active extension range of the right knee of less than 160 °	Use of sedative or tranquilizing medications during the collection period; use of alcoholic beverages 24 hours prior to training sessions or tests; low adherence to training (less than 75% of training sessions); involvement in some stretching exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-7bvg7p	Effect of stretching duration for lumbar muscles on electrical activity and stability of multifidus and lumbar iliocostal muscles	Data analysis completed	Intervention	2020-03-31	<NULL>	<NULL>	3692	Acute effect of stretching the paravertebral muscles, and their maintenance time, on a myoelectric activity of the multifunctional and iliocostal lumbar muscles, and on the static skills and statistics of the lumbopelvic region	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade Estadual do Oeste do Paraná - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-7bvg7p	<NULL>	Volunteers with no history of spinal or lower limb disorders, whether acute or chronic, in the last 12 months; and who did not practice physical activity regularly and systematically for at least twice a week	Volunteers with a history of abdominal, hip and spine surgery, regardless of the time taken; pregnant women; that made use of muscle relaxants; that did not meet the entire collection schedule; or EMG signals with poor record quality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-5wmn5k	Effect of stretching exercises on balance in older women	Data analysis completed	Intervention	2019-12-03	<NULL>	<NULL>	3245	Effect of flexibility training on postural control in older women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-12	Escola de Enfermagem Aurora de Afonso Costa- Universidade Federal Fluminense	Instituto de Educação Física -UFF	https://ensaiosclinicos.gov.br/rg/RBR-5wmn5k	<NULL>	Inclusion criteria were: elderly women aged 60 years or older, those who independently maintained their daily activities through the Baecke Modified Questionnaire, elderly women who practiced only the Prev Quedas water exercise, without participating in another exercise program. physical and those who presented medical examination authorizing the practice of physical exercises.	Exclusion criteria were: elderly women with diseases diagnosed by the doctor that compromised postural control, such as blindness or low vision, labyrinthitis, osteomioarticular diseases, Parkinson&apos;s disease and Alzheimer&apos;s disease, low cognitive ability, previous history of stroke and fall; elderly women who presented two consecutive or more absences in the proposed training, without replacement, in the same week of absence or in the following week; elderly women with a history of falling in the last 12 months; elderly women with low cognitive ability verified through the Mini Mental State Examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-38vv8zz	Effect of Stretching Exercises on occupational stress, manual strength and walking in seamstresses: a	Recruitment completed	Intervention	2023-10-09	<NULL>	<NULL>	6491	Impact of the practice of Stretching Exercises on occupational stress and physical capacity of workers:	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-31	Patrícia nascimento de almeida oliveira	Programa de pós-graduação em ciências do exercício e do esporte/ Universidade estadual do rio de janeiro	https://ensaiosclinicos.gov.br/rg/RBR-38vv8zz	<NULL>	Who act as table seamstresses; That they do not have intellectual and/or motor limitations that prevent them from carrying out the proposed exercises and tests; in addition to providing their consent to participate in the research	Pregnant participants who are not able to practice physical exercises; according to medical indications; Collaborators who are on vacation scheduled for the study period and; Those who are away from their work activities or who are complying with prior notice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-9zx9hy2	Effect of sublingual atropine use on saliva control during intraoral scanning in adults with all teeth	Recruitment completed	Intervention	2026-02-19	<NULL>	<NULL>	8891	Impact of 1% sublingual atropine on intraoral scanning accuracy in fully dentate patients: a triple-blind randomized placebo-controlled clinical trial	<NULL>	n/a, n/a, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Estadual de Ponta Grossa-UEPG	<NULL>	<NULL>	<NULL>	age 18–65 years; American Society of Anesthesiologists ASA physical status I; fully dentate ; 28 permanent teeth excluding third molars; with no untreated caries or extensive restorations; and good oral and periodontal health.	known allergy or hypersensitivity to atropine or placebo components; current use of medications affecting salivary flow;  cholinergic or anticholinergic agents); diagnosis of xerostomia or salivary gland dysfunction;  pregnancy or lactation; significant systemic or neurological conditions affecting saliva production;  orthodontic appliances or fixed prostheses; extensive or defective restorations impacting scanning; active oral lesions or infections; and  strong gag reflex or intolerance to intraoral procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-43mg87	Effect of Sublingual Supplementation with Resveratrol in patients with Renal Disease	Not yet recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1422	Effect of Supplementation of Resveratrol Sublingual on Oxidative And Inflammatory Stress Markers in Hemodialysis Patients with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-15	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-43mg87	<NULL>	Patients of both sexes; over the age of 19; diagnosis of chronic kidney disease and who have been on a regular hemodialysis program for at least 3 months, since this is the time used to confirm the chronicity of renal disease	Patients with a history of hypersensitivity to resveratrol will be excluded from the study; patients with food allergy containing resveratrol;cancer patients; with acute renal failure; in use of anti-inflammatory drugs; use of omega 3 supplementation; bedridden patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-7yk5zmx	Effect of Sucupira on pain intensity in people with knee osteoarthritis	Recruiting	Intervention	2023-05-24	<NULL>	<NULL>	6103	Effect of Pterodon Extract on Pain Intensity in People with Osteoarthritis of the Knee: A Randomized Clinical Trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2023-05-15	Universidade Federal do Tocantins	Universidade Federal do Tocantins	https://ensaiosclinicos.gov.br/rg/RBR-7yk5zmx	<NULL>	Patients between 40 and 80 years old will be included; of both sexes; who have a medical diagnosis of knee osteoarthritis, reports of chronic pain (pain for more than three months (TREEDE, 2015; JOHNSON, 2019) due to arthritis; who know how to read and write; and who can maintain telephone contact via mobile phone .	Having some cognitive impairment or psychiatric disorder that prevents the completion of the study questionnaires (self-report); be diagnosed withrheumatoid arthritis, fibromyalgia, kidney failure, liver disease and gout; have sustained a substantial knee injury within the past 6 months, have a history of arthroscopic or open surgery on the index knee within the past 12 months, or plan to undergo such a procedure within the next 3 months, have received corticosteroid injections within the past 3 months, or acid hyaluronic acid in the index knee in the last six months, who are pregnant or breastfeeding, using any medication or experimental device in the 30 days prior to randomization, or who have any disease or major medical condition that prevents the 2-month follow-up established for the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-4jx82p	Effect of Supplementation of a Protein specific to body composition in the vein and observation of blood values and mortality in ICU patients after abdominal surgery	Recruiting	Intervention	2020-01-15	<NULL>	<NULL>	4145	Effect of early parenteral alaninaglutamine dipeptide complementation on inflammatory markers and prognostic indexes in critically ill patients after major abdominal surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-09	Eliseuda Marinho da Silva	Hospital Universitário Lauro Wanderley	https://ensaiosclinicos.gov.br/rg/RBR-4jx82p	<NULL>	Ages 18-90 years; after major abdominal surgery in ICU; contraindication or failure of enteral nutrition within 48 hours; use of parenteral nutrition for at least 7 days; no history of kidney or liver disease	"Life expectancy greater than 7 days, ie palliative care; unstable hemodynamic state; chronic renal failure where dialysis is insufficient; previous history of severe 24-hour sepsis; liver failure with hepatic encephalopathy or portal hypertension; pre-existing endocrine disorders; continuous 24-hour propofol infusion;
chronic maintenance of systemic steroid therapy; immunocompromise; pregnancy or lactation; severe brain injury;
seizure disorder with anticonvulsant medication; metastatic cancer of lymphoma four; psychiatric history; family members unable to understand the nature and scope of the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-79nxr8	Effect of supplementation of chromium in glucose of diabetic patients	Recruitment completed	Intervention	2014-10-08	<NULL>	<NULL>	340	Effect of Supplementation of Chromium Picolinate on blood glucose with Type 2 Diabetes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-11	Universidade Feral do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-79nxr8	<NULL>	Volunteers diagnosed with type two diabetes mellitus according to the criteria of the American Diabetes Association two thousand and eleven; both genders; presenting glycated hemoglobin greater than or equal to seven percent; not in use of insulin; age between thirty and seventy years; not have taked mineral vitamin supplement in the last three months	Volunteers taking insulin and / or corticosteroids; showing endocrinopathy (cushin syndrome; acromegaly; hyper or uncontrolled hypothyroidism); kidney disease; cancer; infection and anemia; pregnant women; lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-63czrx	Effect of supplementation of nondigestible fibers and bacteria of beneficial effect to the body on blood tests, symptoms of depression and diabetes in patients with type 1 and 2 diabetes.	Not yet recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1585	Effect of prebiotic and simbiotic supplementation on lipidic and glycemic profile, inflammatory markers and symptoms of depression and anxiety in individuals with diabetes mellitus type 1 and 2: randomized clinical trial, placebo-controlled and triple blind	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-11-15	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-63czrx	<NULL>	Volunteers who are diagnosed with type 1 or type 2 diabetes mellitus; both genders; age above 19 years.	Individuals with previous gastrointestinal diseases; previous gastrointestinal surgeries; intolerances or food allergies; use of anti-inflammatory drugs or antibiotics up to three months prior to study or during study; regular use of laxatives; use of opioid narcotic analgesics; use of appetite suppressants; current or previous use up to one month of probiotic symbiotic prebiotics or products enriched with these ingredients; presenting intolerance to prebiotics or probiotics or symbiotics; pregnant or lactating women; following a diet for weight loss or gain in the last three months; current follow-up of unusual diets; alcohol dependence; illicit drugs and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-38nfg2	Effect of supplementation of vitamin and the serum and milk of breastfeeding women	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2047	Effect of supplementation with 800 IU of vitamin E on serum alpha-tocopherol and milk of lactating women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-18	Departamento de Bioquímica da Universidade Federal do Rio Grande do Norte	Departamento de Bioquímica da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-38nfg2	<NULL>	Women 30 to 60 days postpartum who are in the waiting room of the ambulatory care and breastfeeding their child; residents of Natal, state of Rio Grande do Norte; without diagnosis of diseases such as hypertension, diabetes, neoplasias, cardiopathies, diseases of the gastrointestinal and hepatic tract, syphilis, HIV positive; non-smokers and who had deliveries with a single concept and without malformation.	Women who do not have milk; illicit drug users who use vitamin E vitamin supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5byrsc	Effect of supplementation with a synbiotic on the inflammatory response in children and adolescents with cystic fibrosis	Data analysis completed	Intervention	2016-03-11	<NULL>	<NULL>	2227	Effect of supplementation with a synbiotic on markers of the inflammatory response in children and adolescents with cystic fibrosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-03	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5byrsc	<NULL>	Cystic fibrosis group: Children and adolescents up to and including age zero and less than or equal to 15 years; to present a diagnosis of HR based on the sweat test (sweat chloride 60 mmol / L); clinically at least 30 days prior to data collection. For controls without cystic fibrosis: children and adolescents aged 0 years and 15 years without cystic fibrosis; clinically stable at least 30 days prior to data collection	Subjects with fever, trauma, inflammatory diseases (asthma, inflammatory bowel disease, rheumatic disease), psychiatric, degenerative, cardiovascular, diabetes, glucose intolerance, renal failure, primary or secondary immunodeficiency Subjects undergoing antibiotic use at baseline, hormones, non-hormonal anti-inflammatory drugs, immunosuppressants and antihistamines, up to 30 days prior to data collection and subjects in pulmonary exacerbation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-85wj6tj	Effect of supplementation with fruit-based carbohydrate gel on physical performance and gastrointestinal discomfort in healthy high-performance athletes	Recruiting	Intervention	2026-02-27	<NULL>	<NULL>	8922	Effect of supplementation with fruit-based carbohydrate gel on physical performance and gastrointestinal discomfort in healthy high-performance athletes: a non-inferiority, crossover, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-17	Centro Universitário São Camilo	<NULL>	<NULL>	<NULL>	Adult men and women; aged between 18 and 59 years; with experience in long-duration exercises (running over 21 km) for at least 1 year	People with limitations in their respiratory or cardiovascular systems; who use ergogenic supplements chronically (e.g., beta-alanine and creatine); who use hormones or medications that modify physical performance; or who have any muscle injury that prevents them from performing the performance test; people with gastrointestinal diseases (e.g., irritable bowel syndrome or short bowel syndrome, Crohn&apos;s disease, among others); people who use prebiotic, probiotic, synbiotic supplements or use medications such as antibiotics, laxatives, antidiarrheals, antiemetics, antacids, or any substances that affect the gastrointestinal tract.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-9snttn	Effect of supplementation with the amino acid leucine and the compound Beta-hydroxy-beta-methyl-butyrate on the nutritional status, muscle mass, functionality and blood tests of patients on the waiting list for liver transplantation	Not yet recruiting	Intervention	2020-04-27	<NULL>	<NULL>	3775	Effect of Leucine and Beta-hydroxy-beta-methyl-butyrate supplementation on nutritional status, lean mass, functionality, biochemical and molecular markers of patients on the waiting list for liver transplantation	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de Minas Gerais	Santa Casa de Misericoridia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-9snttn	<NULL>	Patients on the waiting list for liver transplantation; both genders; age over 18 years	Pregnant and lactating women; vegetarians; allergic to milk and soy proteins; lactose intolerant; patients taking nutritional supplements of free amino acids; patients using progestational agents, steroids and growth hormone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-9w679s7	Effect of Surf Therapy on psysiology responses in individuals with symptoms of Depression and Anxiety	Recruitment completed	Intervention	2024-06-25	<NULL>	<NULL>	7094	Effect of Surf Therapy on psychophysiological responses in individuals with symptoms of Depression and Anxiety: A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-13	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9w679s7	<NULL>	Inclusion criteria are adults over 18 years old; with symptoms of depression and anxiety; possess sports equipment (sports clothes and sneakers)	Exclusion criteria are uncontrolled chronic diseases; use of controlled medications; disabling physical or clinical condition; previous contact with the modality; professional surfers and attendance rate of less than 70% of scheduled practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-45dh3r	Effect of Sweet Orange Aroma on Pregnant Women in Labor	Recruitment completed	Intervention	2019-07-29	<NULL>	<NULL>	2852	Evaluation of Effect of Aromatherapy with Essential Oil of Sweet Orange (Citrus sinensis L.) no Pain Relief in Pregnant Women in Labor	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-14	Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe	Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-45dh3r	<NULL>	"Term pregnant women (gestational age ? 37 weeks) attended at Maternity Zacarias Júnior in the municipality of Lagarto-SE with indication of normal delivery in the active process of labor;
Pregnant women with cervical dilatation from 4 cm;Greater than 18 years; Sign the Free and Informed Consent Form -"	"Pregnant women who report allergy or intolerance to Citrus sinensis L .;
Pregnant women who report problems with their sense of smell;Pregnant women who report depression, anxiety;Pregnant women presenting with pregnancy morbidities who do not complain of pain in the evolution of labor;  Under 18 years old;  Pregnant women who do not agree to sign the Free and Enlightened"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-9ghqkdx	Effect of systemic Corticosteroid use after Maxillary Sinus Lift Surgeries	Not yet recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6248	Postoperative Period inMaxillary Sinus Lift	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-31	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9ghqkdx	<NULL>	Volunteers patients (18 years of age or older); both sexes; patients in need of maxillary sinus lift surgery	Volunteers with previous chronic or acute pain; volunteers in chronic or acute systemic use (in the 48 hours prior to the procedure) of analgesic, anti-inflammatory and/or muscle relaxant; volunteers with difficulty in understanding instructions (cognitive changes), which impair the application of the scales proposed by the study; illiterate volunteers; volunteers with contraindications for the use of paracetamol associated with codeine; volunteers with contraindication for the use of dexamethasone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-36w6cbr	Effect of task training on prevention of arm contracture in subjects after Stroke – a feasibility study	Not yet recruiting	Intervention	2022-10-06	<NULL>	<NULL>	5652	Effect of task-specific training in the prevention of upper limb contracture in individuals after Stroke- a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-36w6cbr	<NULL>	Individuals aged 18 years or older; clinical diagnosis of stroke (first episode); presence of lacunar infarction; be within the period of up to 10 days after stroke; unilateral clinical signs (hemiparesis with muscle weakness of the upper limb greater than or equal to 10%, confirmed by the average of three measurements of handgrip strength performed with a dynamometer); ability to respond to simple commands, such as “put your hand on your head” and “raise your arm” performed with the non-paretic limb; and who reside in the metropolitan region of Belo Horizonte.	Presence of orthopedic conditions in the upper limbs or others that prevent measurement proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-2nktkhd	Effect of Task-Oriented Therapy, motor enrichment (Time-Baby) on motor development of infants at biological risk for neurodevelopmental delay: Randomized controlled clinical trial	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7275	Effect of Task-Oriented Therapy associated with environmental enrichment on the motor development of infants at biological risk for neurodevelopmental disorders: Randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Centro de Ciências Biológicas e da Saude - CCBS	Universidade Federal de São Carlos - UFSCAR	https://ensaiosclinicos.gov.br/rg/RBR-2nktkhd	<NULL>	Infants of both sexes, aged between 3 and 6 months corrected age, who are considered to be at biological risk by the Ministry of Health, i.e., who present one of the following criteria, will be included in the study: 1) prematurity (&lt;37 weeks of gestational age); 2) low birth weight (&lt;2500 g); 3) Asphyxia (Apgar &lt;7 at 5 min); and the acceptance of the parents and/or legal guardians will be required, by means of signing the Free and Informed Consent Form (TCLE)	Infants who do not present at least one of the criteria for biological risk factors; those who present decompensated respiratory and/or cardiac dysfunctions; parents who present any cognitive or motor impairment that prevents understanding and carrying out the intervention; and infants who do not attend the evaluations will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-1056fgjk	Effect of Telenursing on the Sexuality of women with Breast Cancer	Recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5608	Telenursing in the Sexual Function of women with Breast Cancer: clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-1056fgjk	<NULL>	Women with breast cancer in stages I-IV; Being on cancer treatment (chemotherapy, radiotherapy or hormone therapy) for at least six months, as a survey showed that the majority (66%) of patients develop sexual problems during the treatment of breast cancer and not after (22%) (HUMMEL et al, 2017); Have at least one telephone contact to receive the intervention; Having a partner.	Treatment of another type of cancer; Having hearing impairment, as it makes communication via telephone impossible, which will be assessed through the Whisper Test (LABANCA et al, 2017); Participate in any intervention for the treatment of sexual dysfunction or climacteric, since the comparison between the control group and the intervention group occurs in the best way when there are no co-interventions (drugs, therapies or behaviors) that alter the risk of developing / altering the outcome of interest (HULLEY et al, 2015); Women with mental restrictions, confirmed by medical diagnosis, which makes it impossible to understand the instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-9c3ssc	Effect of telephone consultation associated with short messaging service (SMS) in patients with heart failure	Not yet recruiting	Intervention	2018-03-09	<NULL>	<NULL>	1683	Effect of telephone consultation associated with short messaging service (SMS) on self-care, adherence and quality of life of patients with heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-9c3ssc	<NULL>	Patients older than 18 years; with medical diagnosis of HF, regardless of etiology; have face-to-face service with the multiprofessional team of the specialized IC clinic, since the telephone consultation and the SMS service work with the reinforcement of face-to-face orientations; preserved or diminished ejection fraction; functional class I-III (NYHA) and signing of the informed consent form.	patients with cognitive neurological sequelae who did not have direct telephone contact	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-2s7j59	Effect of telephone follow-up to improve self-efficacy, duration and exclusivity of breastfeeding	Data analysis completed	Intervention	2017-01-26	<NULL>	<NULL>	1171	Effects of a telephone educational intervention on the self-efficacy, duration and exclusivity of breastfeeding: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-05	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2s7j59	<NULL>	Women in the immediate puerperium; With at least six hours postpartum; With single, full-term gestation; With newborns hospitalized in the joint housing; Who are carrying out the practice of Breastfeeding; Have at least one telephone contact.	Puerperas that had been contraindicated to breastfeeding; With mental restrictions that made it impossible to understand the instrument; With children hospitalized in the intensive care unit; Whose children were born with disabilities that impede breastfeeding; Hearing impaired.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-798j8cr	Effect of telesimulation on teaching and learning of basic in-hospital life support in nursing	Not yet recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5877	Effect of telesimulation on teaching and learning of basic in-hospital life support in nursing: a quasi-experiment	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-798j8cr	<NULL>	Nursing students; age equal to or greater than 18 years; having completed the discipline of Technical Bases of Nursing Assistance of the Nursing Graduation Course	Having contact with in-hospital Basic Life Support for less than 12 months; not having equipment or technological conditions to follow the intervention remotely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-3vc4d3	Effect of temperature and storage time off  bleaching agents.	Recruitment completed	Intervention	2020-09-01	<NULL>	<NULL>	4202	Effect of temperature and storage time on dental bleaching effectiveness and sensitivity: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3vc4d3	<NULL>	To be included in this study, males and females participants must be age 18 years or older and be in good general and oral health, healthy maxillary and mandibular anterior teeth, no cervical lesions, no white spot lesions or caries, and no periodontal disease.  The maxillary central incisors of each patient will be evaluated, specifically the médium third of the facial surface. These teeth must present color A2 or higher, according to the Vita scale (VITA Classic, Vita Zahnfabrik, Bad Sackingen, Germany) and Vita Easyshade (Vident,Brea, CA, USA).	The exclusion criteria were participants needing endodontic treatment or those with nonvital teeth,pregnant or breast-feeding women, participants with known allergies to bleaching materials or any other material used in this study, those taking antiinflammatory, analgesic or psychotropic drugs, the presence of restorations in the anterior teeth, parafunctional habits, those with severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth), those who smoked, and those who had undergone tooth-whitening procedures. During the first appointment, tooth sensitivity was measured using an air stream in the cervical region of the anterior teeth and vertical/horizontal percussion. Patients who demonstrated pain (on a verbal scale from 0 to 4) were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-6cgx2k	Effect of TENS on pain relief after surgery	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1615	Effect of Transcutaneous Electrical Nerve Stimulation on postoperative pain relief	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-15	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-6cgx2k	<NULL>	Age greater than 18 years; submitted to abdominal surgery (elective or complicated cholelithiasis, choledocholithiasis, obstructive jaundice, acute pacritatitis, acute cholestasis) and cardiac surgery that are hospitalized at the Hospital de Clínicas of UFTM; With post operative pain complaint; Ability to respond to assessment; Absence of provisional or definitive pacemaker; Sign the TCLE.	• Dehiscence or infection in the surgical incision with exposure of the injured skin; Tumors; New surgery during the intervention or death period; Supra renal disease, use of corticosteroids or steroid anti-inflammatory drugs that alter or influence the dosage of cortisol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-9qks3pc	Effect of testosterone replacement associated with bariatric surgery in men with obesity	Recruiting	Intervention	2023-07-13	<NULL>	<NULL>	6239	Effect of testosterone replacement associated with bariatric surgery in men with obesity: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Hospital e Maternidade São Domingos	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-9qks3pc	<NULL>	Patients with Body Mass Index - BMI &gt; 35; weighing up to 180 kg; with low testosterone levels (&lt;350 ng/dl); classified as hypogonadal; who voluntarily agreed to participate in the research, in addition to understanding and consenting to participation through the TCLE (Free and Informed Consent Form)	Interest in fertility in the 6 months following therapy; diagnosis of active prostate or breast cancer; previous diagnosis of prostate cancer, with less than two years of curative treatment; previous diagnosis of breast cancer; severe voiding symptoms, translated through the IPSS score (International Prostatic Symptom Score) &gt; 19; severe cardiopulmonary disease (eg unstable angina, recent myocardial infarction); personal or family history of thromboembolism; hematocrit above 48%; patients with implanted medical devices such as pacemakers or essential support devices such as monitors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-67bq38w	Effect of testosterone replacement in hypogonadal men with overweight and obesity: a clinical trial	Not yet recruiting	Intervention	2025-10-15	<NULL>	<NULL>	8415	Effect of testosterone replacement associated with diet and physical activity in hypogonadal men with overweight and obesity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Hospital e Maternidade São Domingos	Hospital e Maternidade São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-67bq38w	<NULL>	Obese or overweight men (Body Mass Index above 25 and less than 35; between 30 and 60 years of age; with low testosterone levels (less than 350 nanograms per deciliter); with symptoms of hypogonadism	Individuals interested in fertility in the 6 months following therapy; presence of Diabetes Mellitus; presence of hypertension; presence of Nephropathy; presence of heart disease; presence of Hepatopathy; presence of Depression; presence of anxiety disorders; presence of other hormonal diseases; presence of Hypogonadism of primary cause (testicular failure); diagnosis of active prostate or breast cancer; previous diagnosis of breast cancer; severe urinary symptoms through the score; International Prostate Symptom Score greater than 19; severe cardiopulmonary disease such as unstable angina and recent myocardial infarction; personal or family history of Thromboembolism; hematocrit above 48 percent; patients with implanted medical devices (pacemakers) or essential support devices such as monitors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-88d9kg	"Effect of the application of Linfotaping ® in the immediate postoperative period of
knee on the formation of edema"	Recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2289	"Effect of the application of Linfotaping ® on intraoperative Arthroscopy of
knee joint on the formation of edema"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Estadual de Ponta Grossa	Hospital Universitário Regional dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-88d9kg	<NULL>	"Patients affected by traumatic meniscal injuries and anterior cruciate ligament injury, with indication of
arthroscopy;
Held at the HURCG orthopedics and traumatology outpatient clinic;
Both sexes;
Older than 18 years;
Less than 60 years."	"Peripheral venous insufficiency;
Deep vein thrombosis;
Remove the band before 72 hours of use;
Heart failure III-IV;
Renal insufficiency;
Infectious disease present, uncured;
Cutaneous lesions in the area where the tapes should be applied;
Perform physical therapy during the data collection;
Lymphedema before surgery."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-103c2tr6	Effect of the application of Osteopathic Techniques on pulmonary function and quality of life of individuals with Chronic Obstructive Respiratory Diseases	Not yet recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5568	Effect of Manual Osteopathic Techniques (BMT) on lung function and quality of life in patients with Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2022-09-01	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-103c2tr6	<NULL>	Adult men and women; age group between 35 and 70 years; patients with Chronic Obstructive Pulmonary Disease; stable clinical picture; no exacerbation of the condition in the last three months; agreement and signature of the Free and Informed Consent Form	Pregnant women; individuals with advanced osteoporosis; fractures in the consolidation phase; cancer; thoracic surgeries; decompensated heart disease; systemic arterial hypertension; physical or cognitive factor that limits or prevents the understanding and execution of the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-8grbsz	Effect of the application of previous ischemia on pain sensitivity and aerobic metabolism.	Recruitment completed	Intervention	2018-07-11	<NULL>	<NULL>	1994	Effect of ischemic preconditioning on aerobic metabolism and pain sensitivity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-16	Centro de Ciências da Saúde e do Esporte - UDESC	Centro de Ciências da Saúde e do Esporte - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-8grbsz	<NULL>	Healthy volunteers; both sexes; non smokers; age between 18 and 40 years;	Regular use of any type of medication; smokers; osteo-articular lesion in the last twelve months;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-9hftndz	Effect of the application of sodium perborate on wound healing in the roof of the mouth: a pilot randomized clinical trial	Recruitment completed	Intervention	2021-01-21	<NULL>	<NULL>	4477	Effect of topical application of sodium perborate on tissue repair of palatine wounds: a pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-14	São Leopoldo Mandic	Rehabilitare	https://ensaiosclinicos.gov.br/rg/RBR-9hftndz	<NULL>	Healthy subjects requiring bilateral gingival graft for corrections of mucogingival or peri-implant deformities; non smokers; both genders.	Systemic conditions that contraindicate the procedure; use of drugs that can alter the healing potential of the tissues; smokers; pregnant or lactating women; immunocompromised patients; conditions requiring prophylactic antibiotic therapy; previous palate surgery less than six months; any palate abnormality that makes surgery contraindicated.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-10kn9x8f	Effect of the association of Amitriptyline or Jambu with lidocaine and Prilocaine	Not yet recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7294	Evaluation of the association of Amitriptyline or Acmella Oleracea with Lidocaine and Prilocaine nanocapsules in topical anesthesia: randomized, crossover clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2024-10-05	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10kn9x8f	<NULL>	Age 18 or older and under 30 years old. Both genders. Undergraduate and graduate students of the Piracicaba School of Dentistry. Having accepted and signed the Free and Informed Consent Form - Healthy individuals; those who do not present any type of comorbidity that could generate any risk to the volunteer during the study and do not use continuous medications. Previous experience with local anesthesia, previously with an anesthetic agent of the same class (amide), thus, we can state that they have already had topical use of a similar drug without negative responses. Absence of history of allergy or complications resulting from local anesthetic. Who does not use medications that alter the perception of pain. Upper premolars (14 and 24) healthy on both sides (absence of restorations). Responsive to the Pulp Tester electrical stimulus, an electrical impulse emitting device, called Pulp Tester (PTE) will be used	Pregnant women. Breastfeeding women. Under 18 years of age and 30 years of age or older. Refusal to adhere to treatment using topical drugs. Reporting allergies to any component of the formula. Taking antidepressants, anticonvulsants and anti-inflammatories. Presence of inflammation in the region. Being under direct supervision of researchers (developing some type of activity in undergraduate or graduate studies)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-8wc3mj5	Effect of the association of Dexamethasone with Ibuprofen on Anesthetic Success, Postoperative Pain and Quality of Life after Root Canal Treatment in patients with Preoperative Pain	Recruiting	Intervention	2024-09-17	<NULL>	<NULL>	7348	Effect of Supraperiosteal Injection of Dexamethasone associated with Ibuprofen on Anesthetic Success, Postoperative Pain and Quality of Life after Endodontic Treatment in patients with Irreversible Pulpitis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-08-21	Fundação Francisco Mascarenhas/Faculdade Integradas de Patos-FIP	Universidade Federal de Campina Grande	https://ensaiosclinicos.gov.br/rg/RBR-8wc3mj5	<NULL>	Systemically healthy patients of any gender aged between 18 and 65 years; teeth diagnosed with symptomatic or asymptomatic irreversible pulpitis and symptomatic apical periodontitis (presence of preoperative pain); and preoperative pain ranging from mild to severe on the Heft Parker visual analogue scale	Pregnant or breastfeeding women; patients with allergies, sensitivity or adverse reactions to dexamethasone or ibuprofen; individuals who received any analgesic or anti-inflammatory in the last 12 hours before treatment; and non-restorable teeth, with periodontal disease, root resorption, open apex and calcified root canals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-10bhfy8q	Effect of the association of Dexamethasone with Prednisolone on anesthetic success, Postoperative Pain and Quality of Life after Root Canal Treatment in patients with Preoperative Pain	Recruiting	Intervention	2024-11-26	<NULL>	<NULL>	7539	Effectiveness of Oral and Supraperiosteal Premedication with Prednisolone and Dexamethasone on anesthetic success, Postoperative Pain reduction and Quality of Life After Endodontic Treatment in patients with Preoperative Pain	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal de Campina Grande	Universidade Federal de Campina Grande	https://ensaiosclinicos.gov.br/rg/RBR-10bhfy8q	<NULL>	Systemically healthy patients; of any gender aged; between 18 and 65 years; teeth diagnosed with symptomatic or asymptomatic irreversible pulpitis; symptomatic apical periodontitis (presence of preoperative pain); and preoperative pain ranging from level to severe on the Heft-Parker visual analogue scale	pregnant or breastfeeding women; patients with allergies, sensitivity or adverse reactions to Dexamethasone or Ibuprofen; individuals who received any analgesic or anti-inflammatory in the last 12 hours before treatment; and non-restorable teeth, with periodontal disease, root resorption, open apex and calcified root canals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-3yd3rg	Effect of the Betahistine as a treatment for Tinnitus	Recruiting	Intervention	2019-08-12	<NULL>	<NULL>	4902	Effect of the Betahistine Dihydrochloride as a treatment for Primary Tinnitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Hospital das Clínicas da Faculdade de Medicina de Botucatu/ UNESP	Hospital das Clínicas da Faculdade de Medicina de Botucatu/ UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3yd3rg	<NULL>	Adults from 18 to 70 years; both genders;tinnitus for six months or more;Tinnitus Handicap Inventory (THI) greater than or equal to eighteen (18).	Inability to answer questionnaires. Sensorineural hearing loss greater than 40 dBHL up to 3,000 Hz. Conductive or mistaken hearing loss. Type B or C tympanometric curve. Unilateral tinnitus and / or asymmetric pure tone audiometry, with a difference from the average in the high frequencies (1-4k HZ) to above 20dBHL and / or vestibular symptoms, with limited speech recognition and loss of reflex in the stapedial. Unilateral hearing loss without point-cerebellar angle nuclear magnetic resonance. Pulsatile tinnitus. Meniere&apos;s disease. Patients with gastric ulcers, asthma, pheochromocytoma and hypersensitivity to the use of Betahistine dihydrochloride. Use of medications to treat tinnitus in the last six months. Participants with limitations, feeling of crackling or sound when opening their mouth, facial, mandibular pain or external auditory conduct. Metabolic diseases and psychiatric disorders without clinical control. Diabetes Mellitus with glycated hemoglobin greater than 7%. Neurodegenerative diseases. Rheumatic and autoimmune diseases. Pregnancy and breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-6xsy5t	Effect of the chiropractic and multidisciplinary treatment in the quality of life, functionality and pain in patients with spinal cord injury	Recruitment completed	Intervention	2015-09-16	<NULL>	<NULL>	614	Effect of the chiropractic and multidisciplinary approach in the quality of life, functionality and pain in patients with spinal cord injury	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Eduardo Linden Junior	Universidade Feevale	https://ensaiosclinicos.gov.br/rg/RBR-6xsy5t	<NULL>	Subjects between 18 and 60 years, with vision and hearing preserved, diagnosed with spinal cord injury who accept participate in the study by completing the Statement of Consent.	Do not fulfill the indicated program and do not sign the Statement of Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-10qh48qj	Effect of the combination of platelet-rich fibrin with deproteinized bovine bone on bone formation after pre-radiotherapy tooth extraction in head and neck cancer patients	Not yet recruiting	Intervention	2023-06-26	<NULL>	<NULL>	6177	Effect of combined PRF with deproteinized bovine bone on bone formation after pre-radiotherapy tooth extraction in head and neck cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-10	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10qh48qj	<NULL>	Patients diagnosed with head and neck cancer; both genders; age above 18 years; with indication and need for pre-radiotherapy tooth extraction and who provide consent to participate in this research project by signing the free and informed consent form	Minor patients; patients who do not agree with the free and informed consent form; patients with advanced tumors who, due to the urgency of starting radiotherapy, do not have enough time to perform tooth extractions; patients with health alterations that contraindicate surgical procedures for tooth extraction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-8syq77	Effect of the combination of vaginal cones to the training of the muscles of the intimate region on urine loss in postmenopausal women who do or do not use hormones for menopause	Recruiting	Intervention	2020-04-09	<NULL>	<NULL>	3728	Effect of adding vaginal cones to pelvic floor muscle training on urinary incontinence in postmenopausal women who are on or off hormone replacement therapy - randomized controlled trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade do Estado de Santa Catarina	Thuane Huyer da Roza	https://ensaiosclinicos.gov.br/rg/RBR-8syq77	<NULL>	Have been in the postmenopausal period for at least 1 year; between 45 and 60 years of age; have symptoms of urinary incontinence; use hormone replacement therapy for at least 6 months or not use hormone replacement therapy for at least 3 months.	Have any associated urogynecological disease (gynecological cancer and lower urinary tract infection); undergo gynecological surgery; undergo or have undergone other physical therapy treatment for UI; musculoskeletal changes that may prevent the performance of the proposed activities; not being able to contract PFM; have genital prolapses greater than grade 2 and use of mirena / hormonal IUDs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4n3vwg	Effect of the electrical stimulation of the skin and heated thermal bag in normal labor	Data analysis completed	Intervention	2019-04-08	<NULL>	<NULL>	2586	Physiotherapy assistance in labor: the influence of transcutaneous electrical stimulation and the heated thermal bag during normal labor	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Centro Universitário de Barra Mansa	Hospital São João Batista	https://ensaiosclinicos.gov.br/rg/RBR-4n3vwg	<NULL>	Term, primiparous and multiparous women with ages ranging from 18 to 40 years, with 3 to 4 centimeters of uterine cervix dilatation, without analgesic and / or anesthetic drugs, with preservation of tactile sensitivity and cognition, were included in the study. medical authorization to perform the physiotherapy, without any complications, and who accepted to be part of the study after reading the ELCT	Pregnant women less than 18 years of age, with elective cesarean sections, with pacemakers, with some complications during labor, with morbidities such as diabetes, arterial hypertension or preeclampsia, with cognitive deficit, hypersensitivity to heat, reduced tactile sensitivity, without medical authorization to receive physical therapy and who did not agree to be part of the study after reading the ELCT	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-4y4k7w	Effect of the follow-up of brief interventions for the use of alcoholic beverages and cigarettes in pregnant women: a randomized clinical trial	Recruitment completed	Intervention	2018-07-13	<NULL>	<NULL>	2004	Effect of monitoring of Brief Interventions for Alcohol and Tobacco use in pregnant women: a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-06	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4y4k7w	<NULL>	pregnant women registered in said services; be 18 years old or over and sign the Free and Informed Consent Form.	Not receiving all the planned interventions for the study allocation group; refuse to participate in any stage of the research; being in the eighth or ninth month of gestation at the time of the recruitment of the participants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-10z85rcz	Effect of the heat transmitted by a waves device for the treatment of vulvar lichen sclerosus	Not yet recruiting	Intervention	2021-05-05	<NULL>	<NULL>	4620	Non-ablative radiofrequency as treatment of vulvar Lichen Sclerosus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-07	Faculdade de Medicina da Universidade Federal do Rio Grande do Sul	Fundo de Incentivo à Pesquisa do Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10z85rcz	<NULL>	women with clinical suspicion of vulvar lichen sclerosus, whose diagnosis is confirmed by biopsy, wich accept to participate in the study and sign the term of consent	vulva cancer at inicial biopsy, diagnosis other than lichen sclerosus in the inicial biopsy, current treatment with topical steroid in the vulva, transplanted, pregnant or lactating women and hiv carriers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-4gzbqn	Effect of the Hydrotherapy physical function and quality of life in older people with Chronic Diseases	Data analysis completed	Intervention	2017-10-17	<NULL>	<NULL>	1426	Effectiveness of the Aquatic Physiotherapy program in functional fitness and quality of life in older people with Non-Transmissible Chronic Diseases	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-4gzbqn	<NULL>	Elderly volunteers in the age group between 60 and 80 years old; with hypertension; diabetes; osteoarthritis; with good adaptation to the liquid environment.	Volunteers who present cardiorespiratory; musculoskeletal; neuromuscular dysfunctions that prevent the aquatic intervention program and contraindications of aquatic physiotherapy; such as otitis; hydrophobia; urinary infections and skin lesions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-4vynk5	Effect of the Increase of daily steps in Urinary symptoms and Cardiac function in men aged 50 to 59 years	Data analysis completed	Intervention	2020-08-07	<NULL>	<NULL>	4099	Effect of the Increase of daily steps in Lower urinary tract symptoms, Autonomic cardiac function and Maximum oxygen consupmtion in men aged 50 to 59 years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-27	Hospital Universitàrio da Faculdade de Medicina da Universidade Federal de Juiz de Fora	Hospital Universitàrio da Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4vynk5	<NULL>	men, aged 50 to 59 years, complain of lower urinary tract symptoms with a result greater than or equal to eight in the application of the International Prostate Symptom Score instrument	Tobacco use, conditions that make physical exercise unfeasible, chronic or prostatic diseases, previous history of bladder or prostatic surgery, neurological dysfunction of the bladder, bladder neck or urethral stenosis, as well as lithiasis, carcinoma or bladder polyposis, recurrent UTI, concomitant use or in the month prior to inclusion of any drug or condition affecting urinary function, cardiological and neurological diseases and use of any drug or substance that had action in the autonomic nervous system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-4y59tq	Effect of the Informative Paper on patients and families in a Oncogenetic Ambulatory :evaluation of information and perception of coercion.	not yet recruiting	Intervention	2011-06-30	<NULL>	<NULL>	9	Randomized, double-blind study on the effect of the Informative Paper on patients and families in the Oncogenetic Ambulatory of universitary hospital: evaluation of information and perception of coercion.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-09-01	Hospital de Clínicas de Porto Alegre	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4y59tq	<NULL>	Will be included all adult patients who receive a positive diagnosis at the Ambulatory of Oncogenetics/Medical Genetics Service of the hospital for six months and agree to participate in the research, documented by the Consent Term. Also included are all adult family members who seek care at the same ambulatory for a fixed period and accept to participate in the research, documenting the acceptance by Consent Term.	Will be excluded under 18 years old,those who do not accept and  those familiaries who attend the institution after the deadline.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-2h4mpn	Effect of the Intervention applied to the Exam of Cervical Cancer Prevention and the evaluation of the adequacy of the sampling of the cells collected	Recruiting	Intervention	2019-01-16	<NULL>	<NULL>	2444	Effect of the intervention applied to the Papanicolaou Test and the Adequability of the cytopathological sample	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-07	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2h4mpn	<NULL>	Women who have already started sex life; women to undergo cervical cancer screening at the time of data collection.	Patients younger than 18 years; pregnant women; women who are in the menstrual period or have undergone total hysterectomy; collection slides that have been exposed to conditions of poor storage, transportation and other logistic factors unrelated to the preparation with the uterine cervix material; unavailability of the cytopathological report at the research place.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-4prstkz	Effect of the intervention on diet and exercise in the treatment of gingival disease in adult patients who attend the USFQ dental clinic for treatment. Quito – Ecuador 2022 – 2024.	Recruiting	Intervention	2023-09-14	<NULL>	<NULL>	6433	Effect of the intervention on common risk factors in the treatment of Periodontitis in adult patients who attend the USFQ dental clinic for treatment. Quito – Ecuador 2022 – 2024.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidad San Francisco de Quito	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4prstkz	<NULL>	Age equal to or greater than 30 years; of both sexes; with more than 15 teeth, at least 30% of which have probing depth (PD) and attachment loss (AL) of at least 4mm and bleeding on probing (SS) or with 6 or more teeth with at least 1 site with PD and AL≥5mm; BMI less than 30.	Pregnant or breastfeeding women; Smokers; Patients with other systemic diseases; Scaling and Root Planing performed in the last 12 months; Patients on antibiotic therapy in the last 6 months; Patients on prolonged use of anti-inflammatory drugs; Patients who need antibiotic premedication for dental treatment; Patients who practice regular physical exercise or have been on a diet in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-9jf5bmj	Effect of the Low Level Light Therapy on measurable variables of the autonomic nervous system in people with Cerebral Palsy	Recruiting	Intervention	2024-05-16	<NULL>	<NULL>	7010	Effect of the Photobiomodulation on measurable autonomic nervous system variables in people with Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-20	Centro de Estudos da Educação e Saúde - CER II - Universidade Estadual Paulista	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-9jf5bmj	<NULL>	Age between 5 and 20 years; both genders; cerebral palsy diagnosys; at levels I to V of the Gross Motor Function Classification System (GMFCS)	Individuals with neoplastic areas; bleeding episode; thermal sensitivity disorders; use of photosensitive drugs; have more than two consecutive faults	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-3ngffwr	Effect of the Manual Diaphragm Release Technique on Neurological Patients on Artificial Respiration	Not yet recruiting	Intervention	2020-11-27	<NULL>	<NULL>	4390	Effect of Manual Diaphragm Release Technique on Respiratory Biomechanics in Neurocritical patients on Mechanical Ventilation: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-25	Universidade de Pernambuco	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3ngffwr	<NULL>	Neurocritical patients from the Intensive Care Unit, University Hospital (HU) breathing by artificial airway (endotracheal tube) in PMV.	"Patients with acute decline in neurological status; elevation of refractory intracranial pressure; hemodynamic instability; hypotension (mean arterial pressure less than 60mmHg); pharmacological paralysis; mechanical ventilation with positive end-expiratory pressure (PEEP) bigger then 8cmH2O,
Inspired oxygen fraction (FiO2) greater than 60%; tetany; continuous renal replacement therapy; discomfort status; body mass index bigger then 30 kg / m2; previous chest surgery; chest instability; presence of chest tube; and any clinical changes for handling to perform the technique."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-2pd4s4q	Effect of the maxillary expander device on the size of the nasal cavity	Recruiting	Intervention	2024-01-30	<NULL>	<NULL>	6760	Comparison between the differential opening maxillary expander and the Hyrax expander for pediatric Obstructive Sleep Apnea: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2pd4s4q	<NULL>	Children aged 6 to 12; both genders; presence of Class I or II malocclusion with unilateral or bilateral posterior crossbite; high-risk diagnosis for sleep-disordered breathing according to the Pediatric Sleep Questionnaire (PSQ)	Presence of Class III malocclusion; patients with craniofacial syndromes; history of previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-89z5hb7	Effect of the medication buspirone hydrochloride on teeth grinding as a side effect of anxiety: a previous study	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5648	Effect of buspirone hydrochloride on awake bruxism as a somatic manifestation of anxiety: a pilot study	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2022-11-30	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-89z5hb7	<NULL>	female volunteers, over 18 years old, diagnosed with definitive awake bruxism	participants who do not agree to participate in this study or who have some cognitive difficulty that prevents them from answering the questionnaires; under 18 years old; individuals with epilepsy; with acute intoxication and/or chronic use of alcohol, hypnotics, analgesics, or antipsychotic drugs; with severe kidney and liver failure; history of seizure; current illness or history of serious neurological or psychiatric disorders; history of chronic musculoskeletal pain; previous diagnosis or signs and symptoms of other chronic temporomandibular disorders; use of prescription drugs or drugs with possible effects on sleep or changes in motor behavior or drug interactions with buspirone hydrochloride; smoking; currently undergoing medical or dental treatment; with some dental characteristics, such as loss of more than two posterior teeth, except third molars and users of complete dentures, removable partial dentures and orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-37yq8r6	Effect of the medication Buspirone Hydrochloride on the frequency of teeth grinding secondary to Anxiety	Recruiting	Intervention	2022-05-24	<NULL>	<NULL>	5404	Effect of Buspirone Hydrochloride on the frequency of Bruxism as a somatic manifestation of Anxiety: randomized double-blind placebo-controlled clinical trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-37yq8r6	<NULL>	Both sexes; Older than 18 years; Diagnosis of probable sleep bruxism and definite awake bruxism	"Under 18 years old; Epilepsy and seizure; Acute intoxication and/or chronic use of alcohol, hypnotics, analgesics, or antipsychotic drugs; Smokers; Consumption of more than three cups of coffee per day; Severe kidney and liver failure;
• Severe neurological or psychiatric disorders; History of chronic musculoskeletal pain; Previous diagnosis or signs and symptoms of chronic TMD and sleep disorders (snoring, sleep apnea, and periodic limb movement); Use of prescription drugs or drugs with possible effects on sleep or changes in motor behavior or drug interactions with buspirone hydrochloride; Gastroesophageal reflux; Enlarged tonsils; BMI &gt; 30; Allergy to electrode gel; Currently undergoing medical or dental treatment; Pregnant women; Users of pacemaker or implanted defibrillator; Loss of more than two posterior teeth, except third molars; Users of complete dentures, removable partial dentures and orthodontic appliances; Skeletal Class II"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-7564fd	Effect of the meditation on weight loss, on psychological stress and eating behaviors modifications in women with excess weight	Recruitment completed	Intervention	2018-04-23	<NULL>	<NULL>	1729	Effect of the Healing meditation on weight loss, on stress and on the eating behavior in overweight and obese women.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Escola Bahiana de Medicina e Saúde Pública - EBMSP	Escola Bahiana de Medicina e Saúde Pública - EBMSP	https://ensaiosclinicos.gov.br/rg/RBR-7564fd	<NULL>	Be over 18 years old; to be in a weight loss program at the CCVP or at ADAB; to be overweight or obese; to be literate	Women with diagnosis of psychosis or borderline; using weight loss medications; to be pregnant or having had a delivery in less than 1 year; not to accept to take part in the study; not to sign the Term of Free and Informed Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-8d26mf	Effect of the Mediterranean diet on state inflammatory, lung function and quality of life of patients with cystic fibrosis: randomized controlled trial	Not yet recruiting	Intervention	2015-09-30	<NULL>	<NULL>	623	Effect of the Mediterranean diet on state inflammatory, lung function and quality of life of patients with cystic fibrosis: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal do Rio Grande do Sul	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8d26mf	<NULL>	Patients diagnosed with cystic fibrosis (n=40) confirmed by two tests dosage Na and Cl in the identification or sweat 2 mutations known to be related to illness and aged 6-18 years.	"Patients with advanced lung disease (FEV1 &lt; 40%); Patients using oral corticosteroids in the last two months and inability to
perform pulmonary function tests."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-96584w4	Effect of the Methylene Blue drug in patients with Severe Infection	Recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5081	Effect of Methylene Blue on hemodynamic and metabolic response in Septic Shock patients	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-04-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-96584w4	<NULL>	Aged between 18 and 85 years; of both sexes; who were victims of septic shock of any origin in the first 72 hours of evolution; in use of noradrenaline larger dose 0.3 mcg/kg/min; vasopressin dose 0,05 ui/min; and using mechanical ventilation	Pregnant patients (negative pregnancy test in female patients of childbearing age); in use of serotonergic agents; previous septic shock in the same hospital; use of immunosuppressive therapy; CD4 smaller 200 cells/mm3; neutrophils smaller 500 mm3; palliative care; imminent or inevitable death during hospitalization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-8s2nbf	Effect of the nintendo wii sport video game on rehabilitation of the arms of patients with post polio syndrome: Application research, security and acceptance of the game	Recruiting	Intervention	2018-09-15	<NULL>	<NULL>	2200	Effects of the nintendo wii Sports interactive video game on the motor function of upper limbs of individuals with post polio syndrome: randomized clinical trial of applicability, safety, acceptability	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-15	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8s2nbf	<NULL>	Patients diagnosed with SPP established by the consensus of Healsted &amp; Rossi (1985), patients who are not performing rehabilitation and or physical exercise during the application of the treatment protocol, patients with muscle strength greater than or equal 3 on shoulders and elbows	Patients unable to commit to the established protocol of 14 virtual reality therapy sessions, patients presenting shoulder anterior and or inferior subluxation clinically assessed by palpation greater than or equal to 2 fingers,patients with deformities in the upper limbs that make it impossible to train with the videogame	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-25b7xh	Effect of the pH, consistency and quantity of fluoride of the toothpaste in the fluoride retention on enamel surface	Data analysis completed	Intervention	2014-10-21	<NULL>	<NULL>	343	Effect of the pH, consistency and fluoride concentration of liquid dentifrices in caries control of fluoridated and not fluoridated áreas: randomized clinical trials	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-08-02	Faculdade de Odontologia de Bauru	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-25b7xh	<NULL>	Healthy volunteers, aged between 20 and 35 years old, not using orthodontic appliances and that have not been involved in other studies 3 months before the present research.	Volunteers using orthodontic appliances; volunteers using other fluoridated products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-2qyrrns	Effect of the photostimulation to improve muscle performance of lower limbs in functional test	Data analysis completed	Intervention	2021-01-14	<NULL>	<NULL>	4473	Temporal effect of a single session of cluster phototherapy on lower limb muscle fatigue in sedentary young adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2qyrrns	<NULL>	Volunteers sedentary; healthy; aged between 18 and 18 years; both sexes	Volunteers with neurological and cognitive impairments; cardiorespiratory diseases; the history of orthopedic and traumatological disorders in the lower limbs or trunk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-2g27zn	Effect of the physical training in community-dwelling older women: randomized clinical assay	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	51	Effectiveness of the training with isolated load, training with load associated with the aerobic and isolated aerobic training on the functional and muscular performance, on the plasmáticas concentrations of inflammatory mediators and on the satisfaction with the life in community-dwelling older women	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Centro Universitário de Belo Horizonte - Uni-BH	Centro Universitário de Belo Horizonte - Uni-BH	https://ensaiosclinicos.gov.br/rg/RBR-2g27zn	<NULL>	Aging, community-dwelderly women, without distinction of race and/or social class, with equal age or above of 65 years old.	Previously submitted the orthopeadic surgeries of the inferiors members and/or with history of fracture it less has of one year; those that will not be capable to walking without aid; carrying of neurological illnesses; that to present some type of inflammatory illness in the acute phase that they can intervene with the tests; neoplasia in the five previous years; that to use drugs with ample action on the immunological system; that to present detectable cognitivas alterations by means of Mini-Examination of the Mental State; that to carry through physical activity of regular form for more than two times in the week;  to make use of some type of canal choke of calciun (Ca++), inhibitors of the Converting Converting Enzyme of Angiotensina II (ECA) and use of estatinas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-9mndx8	Effect of the Pilates in elderly	Data analysis completed	Intervention	2014-02-03	<NULL>	<NULL>	273	Effect of the method pilates in flexibility, quality of life and level of pain in the elderly.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-08	Faculdade de Filosofia e Ciências- UNESP	Centro de Estudos da Educação e da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-9mndx8	<NULL>	Women over 60, who reported the presence of chronic musculoskeletal pain, continuous or essentially continuous with exacerbations for at least six months prior to the study.	Neurological symptoms, discrepancy between the lower limbs greater than two centimeters, ankylosing spondylitis, rheumatoid arthritis, herniated disk, tumor, infection, vertebral fracture, cauda equina syndrome, cognitive impairment and cardiovascular or dropouts during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-6jd8nq	Effect of the Pilates in elderly	Data analysis completed	Intervention	2015-02-03	<NULL>	<NULL>	380	Effect of the method Pilates in relation:  thoracic hyperkyphosis and balance postural in elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-08	Faculdade de Filosofia e Ciências (FFC)- Universidade Estadual Paulista &apos;Júlio de Mesquita Filho&apos; (UNESP)	Centro de Estudos da Educação e da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-6jd8nq	<NULL>	Volunteers of the feminine gender,  aged between 60 and 75 years, angle larger than 40º in the curvature of the thoracic spine in the sagittal plane.	They don&apos;t present neurological sequelae, motor and comprehension deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-84gc4bn	Effect of the Pilates Method on the recovery of obese people recovered from Covid-19	Recruiting	Intervention	2021-09-15	<NULL>	<NULL>	4887	Chronic effect of the Pilates Method on the morphological, neurological and metabolic dimensions of Covid-19 obese people recovered: double blind clinical trial	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-16	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-84gc4bn	<NULL>	Presented SARS-CoV-2 SARS confirmed by RT-PCR; Age between 18 and 60 years; Obese before and after hospitalization (BMI:&gt; 30); Low risk of ischemic cardiac event using the Framingham score; Without disturbance of locomotion; Pre-existing diseases such as diabetes and hypertension, which are metabolically healthy; Non-smoker, with no history of lung cancer, bronchial asthma, chronic obstructive pulmonary disease and heart failure; Not having used a corticoid and/or chloroquine and/or hydroxychloroquine protocol.	-Present, during the experiment, any cardiovascular or musculoskeletal aggravation; Do not comply with 80% of the training program; Do not attend 2 training sessions, in a row or; Drop out of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-2zdvfp	Effect of the Radiofrequency and Pelvic Muscle Training in the Treatment of Women with Vaginal Laxity.	Recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3507	Effect of Fractionated Microablative Radiofrequency and Pelvic Floor Muscle Training in the Treatment of Women with Vaginal Laxity: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Faculdade de Ciência Médicas da Universidade Estadual de Campinas	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-2zdvfp	<NULL>	Will be included women 18 years of age onwards and complaining of vaginal laxity assessed by the direct question and Vaginal Laxity Questionnaire, and willingness to participate in therapies at the dates and places scheduled for the proposed treatment.	Patients with decompensated cardiac and metabolic diseases, as well as pacemaker use; cognitive impairment; peripheral or central neurological disorders; presence of any cancer; presence of cervical dysplasia; history of active urinary or vaginal infection; presence of pelvic organ prolapse stage 2 onwards; patients undergoing physical therapy treatment with pelvic floor training; use of estrogen vaginally in the last 6 months; degree of force of contraction of the pelvic floor muscles equal to zero according to the Modified Oxford Scale and patients who have already undergone prolapse or sling correction surgery will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-3cqbw8	Effect of the shape of the posterior teeth on the satisfaction, quality of life and mastication of users of dentures	Recruiting	Intervention	2018-09-17	<NULL>	<NULL>	2204	Impact occlusal surfaces of posterior teeth in satisfaction, quality of life and masticatory efficiency of complete denture wearers bimaxillary	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-19	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3cqbw8	<NULL>	Volunteers should be in good general health; both genders; absence of intraoral lesions and alteration of the perioral musculature detected by palpation; as well as signing the Free and Informed Consent Form. Edentulous individuals less than 5 years old will not be included in the sample.	Those who have given up part of the survey; were in poor health; unable to attend to where the search is performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-52fq9q	Effect of the strategies of an orientation program of lifestyle and healing in patients with venous ulcers	Recruiting	Intervention	2016-08-31	<NULL>	<NULL>	976	Effect of the strategies of an orientation program of lifestyle and the process of healing in patients with venous ulcers: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-52fq9q	<NULL>	Characteristics of venous ulcer: clinical signs observed;Index ABI&gt; 0.8 and &lt;1.3; Over age 18; Venous Ulcer with a minimum of six weeks and &gt;0,2cm2 size; Treatment with inelastic compression therapy.	"Medical diagnosis of osteomyelitis;Patients with Diabetes Mellitus;
Patients with infected wounds;pregnant or breastfeeding; Patients with cognitive understanding of disability"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-3ms5dgd	Effect of the Supported Self-Care technique on adequate follow-up of Warfarin treatment	Data analysis completed	Intervention	2024-10-19	<NULL>	<NULL>	7442	Effect of Supported Self-Care on adherence to oral anticoagulants	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3ms5dgd	<NULL>	Age 18 or older; both genders; Being treated with warfarin; Being under outpatient follow-up for blood clotting control; Presenting an unsatisfactory adherence score (&lt;6) on the Morisky Medication Adherence (MMAS-8); Having a landline or cell phone for teleconsultation; Presenting a satisfactory cognitive evaluation according to the application of the Mini-Cog© test	Participating in another study simultaneously; Pregnant women; Having any communication barriers that limit the implementation of the intervention and/or interviews. More than ten successive and unsuccessful attempts at telephone contact; Failure to show up for blood sample collection for INR assessment purposes for more than 2 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-65k2n4q	Effect of the TCI Mobile app combined with lower extremity constraint-induced movement therapy on real-world lower-limb use after chronic stroke	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8564	Effect of the TCI Mobile app combined with lower extremity constraint-induced movement therapy on real-world lower-limb use after chronic stroke: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-05	Universidade Federal de São Carlos	<NULL>	<NULL>	<NULL>	Adults of both sexes aged 18 years or older with chronic stroke (≥6 months post-stroke); lower limb hemiparesis; ability to walk at least 8 meters independently with or without an assistive device; and adequate cognitive function according to the Mini-Mental State Examination using education-adjusted cutoff scores	Severe visual impairment; other neurological conditions unrelated to stroke; orthopedic conditions unrelated to stroke that could interfere with the intervention or assessments; respiratory disorders that could interfere with performance	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-96qpwn	Effect of the time use of a Bleaching Gel on the efficacy of and Dental Sensitivity to At-home Bleaching	Recruitment completed	Intervention	2018-12-01	<NULL>	<NULL>	3394	Effect of application time of 4% Hydrogen Peroxide on the efficacy of and dental sensitivity to At-home Bleaching: a blind parallel randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-22	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-96qpwn	<NULL>	Volunteers over 18 years old in good general and oral health; who have healthy vital teeth with color A2 or darker according to the Classical Vita scale; and to agree with the free and informed consent form.	Volunteers who have already undergone dental bleaching; who have dental prosthesis or visible enamel cracks; who are pregnant or breastfeeding; a history of previous dental sensitivity; severe dental discoloration from pathologies or use of medications; fixed orthodontic appliance; and that are making continuous use medication that may reduce the sensitivity of the teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-9v2xz6	Effect of the topical application of an anti-inflammatory in the reduction of dental sensitivity after office dental bleaching	Recruitment completed	Intervention	2019-01-23	<NULL>	<NULL>	4843	Effect of Topical Application of Arginine-Associated Ibuprofen on Reduction of Dental Sensitivity after Dental Bleaching in the Office	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-25	UEPG - Universidade Estadual de Ponta Grossa	UEPG - Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9v2xz6	<NULL>	Healthy volunteers; Both genders; Age between 18 and 40 years, with upper and lower anterior teeth with vitality; Adequate oral hygiene; With central incisors that should be A2 or darker in color according to the Vita scale (VITA classical, VITA Zahnfabrik, Bad Säckingen, Germany)	Voluntary smokers; Pregnant and lactating women; Patients with teeth showing staining caused by tetracycline; Fluorosis; Hyperplasia; endodontic treatment; Presence of restorations in the eight upper and lower anterior teeth; Previous dental sensitivity; Parafunctional habits; Cervical lesions (abrasion, erosion and abfraction), periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-3s7t6p	Effect of the training of the musculature of the breathing and of the movement in the capacity to carry out activities in people who undergo coronary artery bypass surgery	Data analysis completed	Intervention	2018-12-17	<NULL>	<NULL>	2388	Effect of respiratory muscle training on the early functional capacity of individuals after myocardial revascularization surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal de Alfenas	Hospital Santa Lúcia de Poços de Caldas	https://ensaiosclinicos.gov.br/rg/RBR-3s7t6p	<NULL>	Volunteers with coronary artery disease; adults between 18 and 80 years; of both sexes.	Volunteers presenting with postoperative complications; with osteomuscular sequelae of stroke; osteomuscular sequelae that compromise the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-93ggrm	Effect of the treatment of oral appliance for obstructive sleep apnea on heart rate variability and on structural and functional characteristics of carotid artery.	other	Intervention	2012-01-04	<NULL>	<NULL>	55	Randomized clinical trial, controled, duble blind, four arms, to evaluate the impact of the treatment of oral appliance for obstructive sleep apnea on heart rate variability and on structural and functional characteristics of carotid artery.	<NULL>	n/a, n/a, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-30	UNINOVE -Universidade Nove de Julho- São Paulo - SP	UNINOVE -Universidade Nove de Julho- São Paulo - SP	https://ensaiosclinicos.gov.br/rg/RBR-93ggrm	<NULL>	Man and woman, at list with 20 years old, ody mass index lower than 30, with no co-morbidities, apnea/hipopnea index moderate to severe, opening of 40mm, mandibular protriusion 7mm, periodontal health.	Psychiatric deseases, use fo any drugs that interfer in sleep, severe temporomandibular dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-9d94bxv	Effect of the type of loading of mandibular overdentures retained by narrow diameter implants produced by additive manufacturing: randomized clinical trial	Recruiting	Intervention	2024-06-21	<NULL>	<NULL>	7083	Effect of the type of loading of mandibular overdentures retained by narrow diameter implants produced by additive manufacturing: randomized clinical trial to analyze the clinical, immuno-inflammatory, functional impact and quality of life indicators	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-11	Faculdade de Odontologia da Universidade Federal de Pelotas/RS	M3 Health Industria e Comercio de Produtos Medicos, Odontologicos e Correlatos S.a.	https://ensaiosclinicos.gov.br/rg/RBR-9d94bxv	<NULL>	Patients of both sexes; in a balanced number without age criteria; no self reported systemic health problems; do not use any medication in the last 3 months that affects the immune response; bone quality without the need for local bone grafting; availability to attend Faculty of Dentistry at the Federal University of Pelotas	Patients who smoke; severe diabetes; blood disorders; hemorrhagic diastasis; drug-induced anticoagulation; rheumatoid arthritis; osteogenesis imperfecta; HIV; use of immunosuppressive medications; history of radiotherapy to the head or neck region, history of previous oral implant insertion; patients who have undergone treatment with bisphosphonates in the last 12 months; if female, not pregnant or lactating; with constant use or with a medical history marked by chronic use of analgesics; anti-inflammatories and psychotropic drugs; need for bone grafting at the implant site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-2hr94r	Effect of the use of a catechin from green tea on the clinical performance of adhesives for dental restorations	Recruitment completed	Intervention	2018-02-05	<NULL>	<NULL>	1627	Effect of epigallocatechin-3-gallate (EGCG) in the clinical performance of an universal adhesive system: a randomized clinical study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal do Ceara	Universidade Federal do Ceara	https://ensaiosclinicos.gov.br/rg/RBR-2hr94r	<NULL>	Be over 18 years old; Have adequate hygiene with absence of periodontal disease; Have at least 20 teeth in occlusion; To present at least four teeth with non-carious cervical lesions (erosion, abrasion and / or abfraction) under occlusion; The lesions should be expulsive, with no retentions, no more than 50% of the cavo-superficial margin in enamel and with cervical margin in dentin.	To Present bruxism;To present lesions previously restored; To present premature contacts; To present prostheses (fixed or removable) involving the teeth with LCNC.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-6nv3c5	Effect of the use of a cream with leucine and lactic acid associated with electrostimulation in contouring facial	Data analysis completed	Intervention	2019-12-11	<NULL>	<NULL>	3274	Development of a cream containing leucine and lactic acid to increase facial muscle tone in adult women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-26	Universidade Norte do Paraná	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6nv3c5	<NULL>	Female sex; be healthy; body mass within the range of 15% of the weight considered normal for men and women, taking into account height and physical structure; skin photo type 1 to 4 (color of skin)	Present any type of physical or mental diseases, which interfere with the use of cream in a continuous form and  in the evaluation measures, have carried out some sort of facial surgery, deficiency or absence of cutaneous sensibility, presence of scars, allergies, hematoma and/or abrasions on the face, perform any type of treatment in aesthetic centers during the study period. Women  were also excluded from the study  with occurrence of tooth pain, pregnant or lactating diseases with infectious process and/or inflammatory process in facial region, acne grade 3, use of pacemakers and metal plates.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-6tsjtz	Effect of the use of a Vibrating Instrument in the application of Dental Adhesive on the retention of restorations in Dental Lesions near the gingiva	Recruitment completed	Intervention	2019-08-26	<NULL>	<NULL>	2895	Effect of using a Vibrating Application Device compared to the Conventional Application of a Self-Etch Adhesive System in the retention of Composite Resin Restorations in patients with Non-Carious Cervical Lesions: double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6tsjtz	<NULL>	Patients older than 18 years will be included; Presence of at least two non carious cervical lesion (NCCL) per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; NCCL with a maximum of 50% of enamel margin.	Pregnant women; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-4sqhppp	Effect of the use of beneficial bacteria on the intestinal microbiota and on nutritional, biochemical and clinical indicators of patients who underwent stomach reduction surgery	Recruiting	Intervention	2021-04-05	<NULL>	<NULL>	4605	Effect of probiotics on intestinal microbiota and on nutritional, biochemical and clinical indicators after gastric bypass in Roux-en-Y	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4sqhppp	<NULL>	Adult patients (18-60 years old); both sexes; who underwent Roux-en-Y Gastric Bypass 1 year ago and signed the IC; Of these, for the intervention with probiotics, only patients who report at least 1 gastrointestinal symptom of moderate to severe intensity in the GSRS questionnaire will be included.	Patients undergoing other surgical techniques will be excluded; those who underwent reoperation or surgical correction; who used antibiotics during the study period or who did not use the placebo / probiotic for 12 days or more (20%) during each phase of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:27
RBR-2tthrr	Effect of the use of body image stimulation in the treatment of ankle sprains in athletes	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	47	Effectiveness of motor imagery in the treatment of ankle sprains in athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2tthrr	<NULL>	Athlete&apos;s soccer with acute ankle sprains, male and female, aged between 16 and 45 years and underwent a medical evaluation prior.	Sprains associated with lower limb bone fracture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-5bch9m	Effect of the use of cellular application for adhesion to treatment of adolescents with Diabetes Mellitus 1	Not yet recruiting	Intervention	2019-06-03	<NULL>	<NULL>	2674	Effectiveness of a mobile application for the clinical and educationalcare for adhesion to treatment of adolescents with Diabetes Mellitus 1: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-05	Eline Saraiva Silveira Araújo	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5bch9m	<NULL>	The population will be comprised of adolescents between 12 and 17 years old; with DM1 in follow-up at the Integrated Center for Diabetes and Hypertension (ICDH).	Those who do not appear during the data collection period or who do not have a smartphone and / or mobile internet will be excluded. There may be losses due to death or a change in the service location.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-9ktwx6	Effect of the use of Chloroquine and Hydroxychloroquine as a possible protector for Infection with the New Corona Virus 2019 in patients with Rheumatic Diseases	Recruiting	Observational	2020-04-09	<NULL>	<NULL>	3727	Evaluation of the effect of chronic use of Antimalarials on the frequency of infection with the New Corona Virus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 - SARS-CoV-2) in patients with Immunomedical Rheumatic Diseases	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-30	Socidade Brasileira de Reumatologia	Departamento de Ciência e Tecnologia - Decit	https://ensaiosclinicos.gov.br/rg/RBR-9ktwx6	<NULL>	Age greater than or equal to 18 years; use of antimalarial drugs for at least 30 days before inclusion; diagnosis of immune mediated rheumatic disease defined according to American College of Rheumatology (ACR) or European League against Rheumatism (EULAR) criteria: rheumatoid arthritis (RA), systemic lupus erythematosus (SLE, Sjogren&apos;s syndrome (SS), systemic sclerosis, myopathies inflammatory diseases, mixed connective tissue disease (DMTC), systemic sclerosis (ES); diagnosis of osteoarthritis (OA) of hands (subgroup).	Previous use of antimalarial, but not current in the last 6 months; history of solid organ or bone marrow transplantation; neoplasm of solid organs or lymphatic or myeloproliferative lineage in the last 12 months with or without adjuvant chemotherapy; use of intravenous human immunoglobulin in the last 30 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-3m4gbs	Effect of the use of desensitizing gel on the final bleaching and tooth sensitivity results - Controlled, randomized, double-blinded clinical trial	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4054	Effect of the use of Desensitizing Agents on the effectiveness of Bleaching and Dental sensitivity - Controlled, randomized, double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-04	Universidade Estadual do Oeste do Paraná	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-3m4gbs	<NULL>	Age between 18 and 25 years; good oral and general health; absence of gingivitis, periodontitis, dental mobility and diabetes; all teeth between the first right upper premolar and the left first maxillary premolar should be present and free of caries and restorations; the maxillary central incisors should be A3 or more saturated.	"Patients who have had a previous dental bleaching procedure; Pregnant and lactating women; Patients who have teeth with severe internal discoloration (resulting from
stained with tetracycline, fluorosis or endodontic treatment) Patients with potentially sensitive teeth such as gingival recession, dentin exposure and poor enamel formation Patients who report sensitivity existing at the time of anamnesis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-44rc4n	Effect of the use of Dexamethasone 4mg in the control of pain after the end of the treatment of the canal	Not yet recruiting	Intervention	2019-08-20	<NULL>	<NULL>	2885	Post-operative pain control with the use of Dexamethasone4mg in patients submitted to endodontic treatment with foraminal enlargement	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-10	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-44rc4n	<NULL>	Patients in need of endodontic treatment. Both genders. ASA I and ASA II patients. Patients over 18 years of age.	Patients with a history of allergy to local anesthetics, corticosteroids and starch. Patients who used analgesics or anti-inflammatories 12 hours before the procedure. Patients were given antibiotics 48 hours before the procedure. Pregnant or lactating patients. Uncontrolled diabetic patients. Patients with open apex. Patients who needed antibiotic prophylaxis prior to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-47jxgzv	Effect of the use of guarana powder (Paullinia cupana) on the modulation of blood markers and mood in young adults	Terminated	Intervention	2022-04-27	<NULL>	<NULL>	6323	Effect of the use of guarana powder (Paullinia cupana) on the modulation of brain-derived neurotrophic factor and depressive symptoms in young adults	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-16	Faculdade de Saúde Pública da Universidade de São Paulo - FSP/USP	Faculdade de Saúde Pública da Universidade de São Paulo - FSP/USP	https://ensaiosclinicos.gov.br/rg/RBR-47jxgzv	<NULL>	Young adult individuals (18 to 40 years old); Body mass index (between 18.5 and 29.99 kg/m2); Be willing to adhere to the study protocol; Be willing to sign the informed consent form (ICF)	Age under 18 and over 40; BMI greater than 29.99 Kg / m²;Having depression, hypertension and / or insomnia; Make use of medication prescribed to control anxiety, depression or other psychiatric disorder; Be a regular consumer of guarana, consumption of coffee, teas or energy drinks more tha 3 doses/day, as adopted in the study by Dood et al. (2015); Being pregnant or nursing; Be participating in another study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-9832jt	Effect of the use of L-Arginine, Caffeine or Creatine supplements associated with physical activity in women with Polycystic Ovary Syndrome with Metabolic Syndrome	Not yet recruiting	Intervention	2018-12-12	<NULL>	<NULL>	2381	Thermogenic Adaptation in Patients with Polycystic Ovarian Syndrome with Metabolic Syndrome Supplemented by Chronology with L-Arginine, Caffeine or Creatine and Training Resisted Exercise - Randomized Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Mato Grosso	Instituto Tropical de Medicina Reprodutiva e Menopausa	https://ensaiosclinicos.gov.br/rg/RBR-9832jt	<NULL>	Women with PCOS who present a metabolic syndrome, with a total age of 20-35 years in the period of the research, who are sedentary or do not practice more than two days of physical exercise, will be selected in the INTRO database , and to sign the Free and Informed Consent Form (TCLE).	Women who are not within the age range standardized by this research, ie obese women with SOP or SM, women who use steroids or other drugs that may interfere with metabolism, hyperprolactinemia, hypo / hyperthyroidism, congenital adrenal hyperplasia classical and non-classical Cushing&apos;s disease and tumors of ovary or adrenal secreting androgen women who are pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-6gmrmbm	Effect of the use of Orthoses on walking of children and adolescents with Charcot-Marie-Tooth	Recruiting	Intervention	2023-05-01	<NULL>	<NULL>	6043	Effect of the use of Assistive Technology Devices on the gait of children and adolescents with Charcot-Marie-Tooth: clinical trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-27	Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6gmrmbm	<NULL>	Participants aged 3 to 18 years, with a medical diagnosis of CMT any subtype; presenting independent deambulation ability; clinical impairment of the distal lower limbs with postural alterations in the feet, identified by the Foot Postural Index or plantar pressure analysis, muscular strength of the dorsiflexors and/or plantar flexors less than 3 in the manual test; and who accept and sign, together with their legal guardians, the Terms of Consent and Informed Consent.	Participants diagnosed with diabetic polyneuropathy; those with a history of surgery or trauma to the lower limbs in the six months prior to the evaluation; and those who do not understand the commands offered by the evaluator.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-2rzt5c	Effect of the use of the anchoring system for patients with chronic peripheral vestibular	Recruiting	Intervention	2014-10-08	<NULL>	<NULL>	668	Effects of the use of the anchor system in the rehabilitation of balance in individuals with chronic peripheral vestibular disorder: randomized blind controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo - USP	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo - USP	https://ensaiosclinicos.gov.br/rg/RBR-2rzt5c	<NULL>	"Eligibility criteria fall within individuals of both sexes , aged 50 years, suffering from chronic peripheral vestibular disease with presence of dizziness and decreased body balance, and nonspecific lightheadedness or feeling dizzy, and peripheral etiology and daily occurrence , weekly, monthly for at least three months , in which the symptoms of vertigo , dizziness , postural instability of vestibular origin , are not responding positively to conventional RV , which includes the reorganization of the VOR .
Will be classified as patients who do not respond positively to RV , those who remain with otoneurology symptoms for more than six months after the start of the intervention , no clinical improvement observed .
The diagnosis of chronic peripheral vestibular disease will be confirmed at the Otolaryngology Department of Ophthalmology , Otorhinolaryngology and Head and Neck Surgery , Hospital das Clinicas, Faculty of Medicine of Ribeirão Preto, University of São Paulo - FMRP - USP."	Exclusion criteria from the survey include: patients who are using drugs (benzodiazepines and anticonvulsants) acting on the balance, calcium channel blockers (cinnarizine and flunarizine), plus motor, visual or cognitive restrictions that prevent the realization of and reviews proposed intervention, as well as with systemic diseases without drug therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-9mys6q	Effect of the use of Toothpaste with Desensitizers in reducing Dental Sensitivity and Quality of Life after in-office Dental Bleaching	Data analysis completed	Intervention	2018-06-29	<NULL>	<NULL>	1945	Effect of the use of Dentifrices with Desensitizers in the ental Sensitivity reduction and Quality of Life after in-office Dental Bleaching: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9mys6q	<NULL>	with good oral health;  anterosuperior teeth with vitality, free of cavities and restorations on the vestibular surface; they should  be dissatisfied with the color of their teeth; they should have upper central incisors with coloration equal to or darker than A2, according to the Vita Classical color scale in order of luminosity.	stimulated or provoked dentin sensitivity; enamel cracks; dentinal exposures; severe intrinsic stains on the teeth (such as tetracycline or fluorosis); periodontal disease without treatment;  using any anti-inflammatory, analgesic and antioxidant action drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-2gdd984	Effect of the use of two different types of dental motors on the perception of pain, swelling and difficulty opening the mouth postoperatively in Dental Extractions of lower wisdom teeth: a double-blind randomized clinical trial in a split-mouth	Not yet recruiting	Intervention	2023-07-24	<NULL>	<NULL>	6263	Effect of using a 1:3 multiplier surgical contra-angle versus high-speed pen on the perception of postoperative pain, edema and trismus in mandibular third molar Extraction: a double-blind randomized clinical trial in a split mouth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-25	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-2gdd984	<NULL>	Will be included in the study, 24 patients aged between 18 and 30 years and without impairment of general health according to medical history (healthy) and physical examination, who agree to participate in the study. Through clinical and radiographic examination, patients with indication for bilateral extraction of mandibular third molars, asymptomatic and in class IIB position, according to the Pell &amp; Gregory classification, will be selected.	Exclusion criteria will be considered: (I) history of use of any type of analgesic, anti-inflammatory and antibiotic medication in the 15 days prior to the beginning of the surgical procedure; (II) history of hypersensitivity to drugs, substances or materials used in this experiment; (III) pregnancy or lactation; (IV) pericoronitis or other local infection within 15 days prior to the surgical procedure; (V) and people with a history of acute or chronic systemic disease, such as hypertension or diabetes, for example.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-3rj7tt	Effect of the weekly frequency, with equalized volume, of the Strength Training with instability on the functional capacity of elderly people	Recruiting	Intervention	2020-03-03	<NULL>	<NULL>	3550	Effect of weekly frequency with equalized volume of Strength Training on unstable surface on neuromuscular capacity, quality of life and fear of falling in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Pernambuco	Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3rj7tt	<NULL>	Participants must be 60 years of age or older, have not practiced strength exercises for at least 6 months, have no disabling diseases and be able to understand and make study commitments	Individuals who do not have the time to participate in the experimental and elderly groups that are currently participating in another exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4njb3p	Effect of therapeutic bath in pain, in sleep and vital sign in babies influenza in a semi-intensive therapy unit of university hospital in the south of Brazil	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2171	Effect of therapeutic bath in pain and physiological variables of infant influenza in a semi-intensive therapy unit of university hospital in the south of Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-18	UCPEL - Universidade Católica de Pelotas	UCPEL - Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-4njb3p	<NULL>	Neonates and infants hospitalized at the Neonatal Semi-Intensive Therapy Unit; with a life time of at least 72 hours, 1,250 grams; up to 6 months of age; which are parents or guardians agree to participate in the study.	clinically unstable preterm infants; contraindications to the immersion bath; new borns weighing less than 1,250 kg; infants who present temperature changes; need for ventilatory support; infectious process; neurological problems; facial congenital malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-4pkhf4b	Effect of Therapeutic Laser Compared to Standard Care on Pain and Inflammation in Postoperative Cesarean Section: Comparative Study	Not yet recruiting	Intervention	2024-06-13	<NULL>	<NULL>	7067	Efficacy of Low-Level Laser compared to usual care on pain Intensity and inflammatory modulation of immediate postoperative cesarean section wound: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-24	Departamento de Fisioterapia da Universidade Federal de Pernambuco - Campus Recife	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4pkhf4b	<NULL>	Participants who are over eighteen years old; participants without any clinical or obstetric complications and who have a score higher than three on the Visual Analog Scale VAS	Participants lacking capacity to consent; postpartum participants who have experienced complications such as hemorrhage; cesarean wound dehiscence; or sepsis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-563rmd	Effect of therapeutic laser on lip performance	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3881	Effect of low-level laser therapy on the performance of the orbicularis oris muscle	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-563rmd	<NULL>	Age between 18 and 35 years; sign the Informed Consent Form	use of myorelaxing and/or anti-inflammatory drugs; photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the application site; history of cancer; use of a pacemaker or other electronic implant; having undergone previous orofacial myology therapy; presence of a beard or mustache at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-32rp22	Effect of therapeutic laser on the lips fatigue	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4045	"Effect of low-level laser on the 
electromyographic fatigue of the orbicularis oris muscle"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Centro Universitário Metodista Izabela Hendrix	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-32rp22	<NULL>	"Age between 18 and 60 years; sign the
Informed Consent Form"	"Craniofacial anomaly or disease with neuromuscular involvement; use of myorelaxing and/or anti-inflammatory drugs; 
photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the
application site; history of cancer; use of a pacemaker or other electronic implant; having undergone previous orofacial myology therapy; presence of a beard or mustache at the time of data collection."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-45rdh2	Effect of Therapeutic Touch for preventing injuries in the feet of people with diabetes	Recruitment completed	Intervention	2015-02-24	<NULL>	<NULL>	401	Effect of Therapeutic Touch for prevention of Diabetic Foot	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Universidade Federal de Alfenas	Conselho Nacional de Desenvolvimento Cientítfico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-45rdh2	<NULL>	Volunteer with Diabetes Mellitus Type 2 diagnosed for at least five years; of both sexes; registered in HIPERDIA; medical care in the unit; over the age of 18 years; have at least one risk factor for impaired skin integrity, according to established nursing diagnosis &quot;risk of impaired skin integrity&quot; (NANDA,2013).	Volunteers with cognitive disabilities; presence of foot ulcers; presence of amputations of the lower limbs; presence of thrombosis; uncontrolled hypertension; in other unconventional treatment modality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-4shpqhj	Effect of Therapeutic Ultrasound on recovery after Elbow Fracture surgery	Not yet recruiting	Intervention	2025-04-24	<NULL>	<NULL>	8050	Additional effect of Therapeutic Ultrasound in postoperative rehabilitation of Elbow Fractures: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-16	Universidade Federal de Juiz de Fora	Programa de Pós Graduação em Saúde Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4shpqhj	<NULL>	Individuals aged 18 to 70 years; of both sexes; referred for physiotherapy treatment from the sixth week of surgical intervention after elbow fractures; with limited range of motion greater than or equal to twenty degrees of extension deficit; or less than or equal to one hundred and twenty degrees of elbow flexion; elbow fractures involving the distal segment of the humerus; proximal segment of the ulna; fracture of the neck and head of the radius according to Mason&apos;s Classification; elbow fractures and dislocations such as Hotchkiss&apos;s terrible triad; Monteggia lesion; transolecranon fracture and dislocation	Patients with bilateral elbow fractures or whose indicated treatment is total elbow arthroplasty; pregnant women; neurological, rheumatic or psychiatric diseases that compromise rehabilitation; previous history of elbow stiffness; previous surgical procedure on the elbow; existence of Kirschner wires or cerclage wires in the proximal ulna and distal humerus; Mini-Mental State Examination score of less than 24 points for those with higher education and 18 points with low to moderate level of education	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-5d4s4f	Effect of therapies combination to healing of venous ulcers, leg pain and self rated health and quality of life of patients in a six month follow-up	Recruitment completed	Intervention	2018-07-12	<NULL>	<NULL>	2000	Effectiveness of interdisciplinary and multidimensional technologies in the healing of venous ulcers, leg pain and self rated health and quality of life of patients in a six month follow-up in primary care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal de Goiás	Fundação de Amparo à Pesquisa do Estado de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5d4s4f	<NULL>	Being 18 years of age or older; scoring normal on Mini Mental State Exam, considering education level; presenting a leg ulcer with clinical signs of impaired venous circulation with ou without the low impairment of arterial circulation	People with liver disease, people with kidney disease, people who present no palpable peripheral arterial pulses, preventing the verification of ankle arm index (AAI); people who had an AAI less than 0.8 or greater than 1.3, or intermittent claudication when walking 250 meters or less which fades at rest, or paleness on elevation of the affected limb, even with AAI within the inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-9mvgrq	Effect of three bandages on the flat foot of healthy young adults	Recruiting	Intervention	2017-08-29	<NULL>	<NULL>	1361	Effect of rigid, elastic and hyperelastic banding on excessive pronation of healthy young adults: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade de Brasília	Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9mvgrq	<NULL>	"Authorize the evaluation and the procedure by means of the Free and Clarified Consent in accordance with the resolution CONEP / CNS Nº. 466/2012;
Being male;
Age range between 18 and 30 years;
To present a body mass index between 18.6 and 24.9 kg / m²;
Have no history of injury in the last 6 months in the lower limbs;
Present at least one pronated foot"	"History of musculoskeletal and / or neurological lesions that may affect gait;
History of surgeries and / or traumas of any nature in lower limbs, pelvis or spine in the last six months that may affect gait;
Present allergy to some type of bandage or tissue, evaluated through allergy test;
Have recently done or still do treatment for PE;
Having cutaneous or malignant diseases and bacterial infections in the place to be applied the bandages;
Report any pain or any sign of injury during the evaluations;
Make use of medicine that impairs balance, such as sedative or hypnotic;
Intake of alcoholic beverages within 48 hours prior to evaluation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-6qjtb4	Effect of Tibial Nerve Stimulation in patients with Urinary Incontinence after surgery to Remove the Prostate	Not yet recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3402	Percutaneous Tibial Nerve Stimulation in patients with Urinary Incontinence after Prostatectomy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-17	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6qjtb4	<NULL>	Men who underwent radical prostatectomy with urinary incontinence after the cateter removal, defined by a volume greater than 1.0 gram on the pad test and who agreed to participate in the research	Men who are using anticholinergics, tricyclic antidepressants, who have neurological disorders or urethral stricture. Men with complications such as radiotherapy will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-10gky7y9	Effect of Time Under Tension in Recreational Runners	Recruiting	Intervention	2024-07-08	<NULL>	<NULL>	7124	Acute Effect of Isometric Strength Training and Time Under Tension on the Performance of Recreational Runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-18	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-10gky7y9	<NULL>	Volunteer for research; be 18 years of age or older; run at least three times a week with an average weekly mileage of 16 kilometers; have an average running pace of between 5 and 5:30 minutes per kilometer over a long distance; participate in a strength training program at least once a week with at least three months of practice, report no osteoarticular injuries during the last three months that compromised strength exercises and running; and have at least one year&apos;s experience in long-distance running	Individuals who do not perform all steps as instructed; present depravity in the upper respiratory tract; injuries that make it impossible to perform maximum effort during the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-5vsm8t7	Effect of timing of beetroot juice ingestion on magnitude and duration of post-exercise hypotension in hypertensive patients	Recruiting	Intervention	2021-10-10	<NULL>	<NULL>	4958	Effect of timing of beetroot juice ingestion on magnitude and duration of post-exercise hypotension in hypertensive patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-03	Ufpb - Universidade Federal da Paraiba	Ufpb - Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-5vsm8t7	<NULL>	"Volunteers diagnosed with hypertension according to the seventh Brazilian Guidelines on Hypertension; with SBP between 130 and 160 mmHg and DBP between 85 and 90 mmHg; using antihypertensive drugs; except for the beta-blocker class; are not assiduous consumers of
beetroot; have a recent history in the last month of performing aerobic exercises with
sessions of at least 60 minutes; not being a smoker and being able to carry out the protocol of
physical exercise"	Volunteers who do not participate in all experimental procedures; present gastrointestinal discomfort to beetroot juice or control drink; change the medication, diet or physical training pattern during the experimental procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-9x5whvf	Effect of tomato supplementation on oxidative stress and cardiac function in hemodialysis patients	Data analysis completed	Intervention	2021-12-08	<NULL>	<NULL>	5085	Effect of tomato (Lycopersicon esculentum) supplementation on oxidative stress markers and cardiovascular function in patients with chronic kidney disease treated by hemodialysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Faculdade de Medicina de Botucatu UNESP	Faculdade de Medicina de Botucatu UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9x5whvf	<NULL>	Patients older than 18 years old and prevalent in chronic HD for at least three months were included;	Patients with cancer, HIV-positive undergoing antiretroviral therapy, end-stage liver disease, heart failure disease with ejection fraction less than 30%, clinical diagnosis of acute infection, (or using antibiotics), chronic inflammatory diseases, such as systemic lupus erythematosus and chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-9gtr9sc	Effect of Tooth Enamel humidity on Tooth Whitening using High-concentration Carbide Peroxide: A Randomized Clinical Trial	Not yet recruiting	Intervention	2023-07-14	<NULL>	<NULL>	6240	Effect of Enamel humidity on the action of High-concentration Carbide Peroxide: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-24	Universida Federal de Sergipe	Universida Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9gtr9sc	<NULL>	Any individual who is interested in teeth whitening at least 18 years of age, patients who have a color equal to or darker than 2.5 M2 on the maxillary anterior canines (on the Vita Bleach Guide scale) and agree to participate and sign the informed consent form	Presence of restorations in the upper anterior teeth, presenting any pre-existing general medical and/or oral condition that put the individual at risk during the study, such as systemic fungal infections, being pregnant or breastfeeding, dental treatment planned to be performed during the course of the study , generalized periodontal disease, complex intrinsic staining due to tetracycline, fluorosis or hypocalcification, and previous tooth sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-6cyvhxx	Effect of toothbrush head size on teeth cleaning	Recruiting	Intervention	2022-07-20	<NULL>	<NULL>	5497	Efficacy of toothbrushes with different head sizes in removing biofilm and evaluating supragingival inflammatory parameters: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-6cyvhxx	<NULL>	Individuals of both sexes; Age between 24 and 65 years; With availability to participate in all experimental periods of the study; With at least 20 natural teeth present; They must not be participating in any other study or research; Patients diagnosed with gingivitis.	Dentistry students; smokers; Individuals with hyperglycemia; Pregnant and lactating women; Individuals with carious lesions and/or root remains in the mouth; Individuals diagnosed with periodontitis. Individuals who use metallic or acrylic removable partial dentures; Individuals who use fixed orthodontic appliances; Individuals who have consumed anti-inflammatory drugs and/or corticosteroids within 3 days of the experimental stage; Subjects who had consumed antibiotics three months before the present study; Individuals who have received dental prophylaxis or periodontal treatment within the last three months. Individuals who need antibiotic prophylaxis prior to dental procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-88k7mvw	Effect of topical application of 10% Silver Nitrate solucion versus 10% Potassium Hydroxide in the treatment of Molluscum Contagium	Not yet recruiting	Intervention	2025-11-01	<NULL>	<NULL>	8474	Efficacy and safety of topical application of 10% Silver Nitrate solucion versus 10% Potassium Hydroxide in the treatment of Molluscum Contagium	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Patients with a clinical diagnosis of molluscum contagiosum, without perimolluscal eczema; aged between one and twelve years; of both sexes; whose parents or legal guardians have signed an informed consent form	Individuals with congenital or acquired immunosuppression; children who have used another treatment in the last month; patients with lesions on the face or genital region; children with allergies to the components of the medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:25
RBR-23ch2p	Effect of topical application of eugenol on dental sensitivity caused by in-office dental bleaching	Recruiting	Intervention	2020-01-14	<NULL>	<NULL>	3357	Effect of topical eugenol application on dental sensitivity caused by in-office bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-23ch2p	<NULL>	Patients older than 18 years are included; with good oral and general health; with the maxillary anterior teeth free restorations and presenting no carious lesion; which possess the color of teeth A2 or darker depending on the color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening; pregnant patients or lactating; who report tooth sensitivity; severe browning (staining by tetracycline, fluorosis or endodontics); with deleterious habits; people with dental prostheses and orthodontic appliances and any other oral pathology . Although patients will be excluded that present systemic changes such as stomach, heart, kidney and liver problems, diabetes, hypertension or are making continual use of drugs with analgesic and anti-inflammatory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-8qdf7t	Effect of topical Dipyrone application in tooth sensitivity caused from In Office Dental Bleaching	Data analysis completed	Intervention	2016-01-29	<NULL>	<NULL>	1464	Effect of the use of topical Dipyrone in tooth sensitivity resulting from In Office Dental Bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-27	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-8qdf7t	<NULL>	Patients older than 18 years are included; with good oral and general health; with the maxillary anterior teeth free restorations and presenting no carious lesion; which possess the color of teeth A2 or darker depending on the color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening, pregnant patients or lactating; who report tooth sensitivity; severe browning (staining by tetracycline, fluorosis or endodontics); with deleterious habits; people with dental prostheses and orthodontic appliances and any other oral pathology. Although patients will be excluded that present systemic changes such as stomach, heart, kidney and liver problems; diabetes; hypertension or are making continual use of drugs with analgesic and anti-inflammatory or who have allergies to Dipyrone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-67jkxsj	Effect of Topical Melatonin Gel on the healing of post-extraction sites	Data analysis completed	Intervention	2025-08-12	<NULL>	<NULL>	8202	Evaluation of the effect of Melatonin Gel on post-extraction Dental Socket preservation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Comando da Aeronáutica	Programa de Pós Graducação em Odontologia da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-67jkxsj	<NULL>	Healthy volunteers over 18 years of age; of either gender; with an indication for the extraction of premolar or molar teeth from any dental arch who have adjacent teeth present; and are willing to cooperate with the study	Volunteers presenting with teeth affected by acute periapical or periodontal infections (abscesses); those with severe systemic diseases or under medications such as chemotherapy, anticoagulants, corticosteroids, antiresorptive drugs, or immunosuppressive agents; patients using systemic melatonin; individuals with decompensated chronic diseases; metabolic bone disorders; any motor dysfunction that impairs or prevents proper oral hygiene; smokers (former smokers must have ceased smoking for at least 6 months); pregnant women; and patients who have undergone radiotherapy within the past 5 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-6w7vwb3	Effect of traditional 5-Fluorouracil emulsion versus smaller particles of 5-Fluorouracil emulsion in the treatment of skin aged by sun exposure and prone to developing Skin Cancer	Recruitment completed	Intervention	2024-06-06	<NULL>	<NULL>	7054	Effect of classical 5-Fluorouracyl emulsion versus compounded 5-Fluorouracyl emulsion with hydrophilic polymer and high-pressure homogeneization on Field Cancerization and Advanced Photoaging	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2022-01-01	Escola Paulista de Medicina/Universidade Federal de São Paulo - UNIFESP	Escola Paulista de Medicina/Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-6w7vwb3	<NULL>	Male or female; over 50 years; phototypes I to III, according to Fitzpatrick Scale; forearms with clinical diagnosis of severe or advanced photoaging, associated with actinic keratosis; agreement to avoid photoexposure during the period of therapy; ability to understand and strictly respect the guidelines provided; availability for periodic visits	Smokers; including indirect smokers; or former smokers, who stopped smoking for at least two years; topical treatments with tretinoin less than six months and other retinoids, alphahydroxy acids, polyhydroxy acids, betahydroxy acids and ascorbic acid less than three months; treatment with superficial chemical peels; microdermabrasion and fractional lasers less than three months; oral retinoid less than six months; history of hypersensitivity to parabens; infectious or inflammatory dermatoses diagnosed on the arms; previous chemotherapy or radiotherapy treatment; clinical evidence of immunosuppression; presence or history of photodermatosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-9qg25v9	Effect of traditional Chinese medicine in postoperative pain control after wisdom extraction.	Recruitment completed	Intervention	2021-07-07	<NULL>	<NULL>	4781	Effects of auriculotherapy in the control of postoperative pain in patients submitted to erupted third molar exodontia	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2017-12-21	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9qg25v9	<NULL>	Patients who after diagnosis are indicated for bilateral extraction of asymptomatic third molars and in similar surgical positions and difficulties, analyzed through panoramic radiographs.	Patients under 18 years of age; patients classified as ASA III or IV; history of use of pain or anxiety medication in the 15 days prior to the start of the research; history of hypersensitivity to drugs, substances, or materials used in this experiment; pregnancy or lactation; previous history of pericoronitis, as it changes the pain sensitivity of the patient; systemic diseases using control medication; odontophobia; very anxious patients, using as a parameter for classification the Corah scale; mental disability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-6y85xgt	Effect of training associated with simulated altitude on blood, autonomic, aerobic and anaerobic parameters of amateur runners	Recruitment completed	Intervention	2023-08-18	<NULL>	<NULL>	6360	Effects of training associated with recovery hypoxia and tapering on hematological, autonomic, aerobic and anaerobic parameters on amateur runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6y85xgt	<NULL>	Physically active men; age between 18 and 35 years	Limitations to high-intensity physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-7hqk8t	Effect of Training Functional Activities on biological factors after Stroke	Recruitment completed	Intervention	2018-01-26	<NULL>	<NULL>	2678	Efficacy of Task-Specific Training in changing neurotrophic factors and impact on clinical outcomes in individuals with Stroke: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7hqk8t	<NULL>	Volunteer with clinical diagnosis of primary or recurrent cerebrovascular accident for more than six months; aged 18 years or over; with the capacity to independently roam more than 10 meters with or without gait; sedentary lifestyle or who are insufficiently active; with medical release for the practice of physical activity.	Patients with cognitive impairment (Mental State Examination) will be excluded; with a history of severe heart disease and uncontrolled blood pressure; with presence of pain or pathology that interferes with the intervention, such as vestibular disorders, severe arthritis or any disease of the nervous system; that do not allow or fear the collection of blood; who have made use of anti-inflammatory drugs in the last month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-3kxkzn	Effect of training in vibrating plataform in subjects with Chronic Obstructive Pulmonary Disease	Data analysis completed	Intervention	2015-08-28	<NULL>	<NULL>	1553	Effect of whole-body vibration training in subjects with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-3kxkzn	<NULL>	75 subjects of both genders; with stable COPD; age between 45 and 80 years; women after menopause.	Acute or chronic associated disease not stable; included in  some form of physical training; use of antiinflammatory and immunosuppressive medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-4f253v	Effect of training with exercises using movements from day to day on anthropometry, functional capacity and blood glucose elderly with diabetes	Recruitment completed	Intervention	2016-07-27	<NULL>	<NULL>	938	Effect of functional training on anthropometric parameters, functional and glycemic elderly with diabetes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-09	Universidade do Sagrado Coração	Conselho Nacional de Pesquisa (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-4f253v	<NULL>	Elderly, above 60 years, with type 2 diabetes; both sexes; with prior medical evaluation; whithout physical exercises for at least three months.	Health problems and / or orthopedic limitations that contraindication to practice the exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-7xfkpx	Effect of training with instability on a platform in patients with Parkinson&apos;s disease	Recruiting	Intervention	2018-11-22	<NULL>	<NULL>	2342	Effect of postural perturbation training on the ability to recover body balance in individuals with Parkinson&apos;s disease with freezing of gait	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-19	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xfkpx	<NULL>	Participants should present a clinical diagnosis of Parkinson&apos;s disease obtained by a neurologist; to present the gait blocking symptom, with scores greater than or equal to 4 by the New Freezing of Gait Questionnaire scale; stages 3 or 4 of the disease by the HoehnYahr modified scale, score equal to or greater than 23 in the Mental State Mini Examination, not presenting neurological or physical dysfunctions, other than those associated with the disease, that may affect balance control.	Inability to remain balanced after postural disorders due to displacement of the body support base, lack of attention to procedures or ability to understand instructions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-10nbjgb9	Effect of Transcranial Direct Current Stimulation (tDCS) in Attention Deficit Hyperactivity Disorder (ADHD)	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	8187	Therapeutic response of Transcranial Direct Current Stimulation (tDCS) in Attention Deficit Hyperactivity Disorder (ADHD): a double-blind pilot clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-10	Universidade Estadual do Sudoeste da Bahia	Clínica Quality	https://ensaiosclinicos.gov.br/rg/RBR-10nbjgb9	<NULL>	Volunteers aged between 18 and 50 years; both sexes; diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) confirmed by a specialist through clinical evaluation; if previously diagnosed with Attention Deficit Hyperactivity Disorder (ADHD), not using psychostimulant medication in the last 30 days; participants must be available for daily sessions of Direct Current Electrical Stimulation	Severe depression; Moderate to severe anxiety; Bipolar disorder with an episode of mania or depression in the last year; Schizophrenia or other psychotic disorder; Autism Spectrum Disorder; positive screening for substance use (alcohol, tobacco and other psychoactive substances); severe neurological and organic comorbidities (seizures, neoplasms, previous neurosurgery); carriers of cochlear implants or other metal implants; pregnant women or recent intention to become pregnant; family history of sudden death before age 50	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-4mw25f	Effect of Transcranial Direct Current Stimulation on the physical conditioning of children and adolescents with Cerebral Palsy.	Not yet recruiting	Intervention	2020-06-10	<NULL>	<NULL>	3918	Effect of Transcranial Direct Current Stimulation on the physical fitness of children and adolescents with Cerebral Palsy: a crossover, placebo-controlled, double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-4mw25f	<NULL>	The participants included in the study will be children and adolescents with a diagnosis of CP of the spastic diparesis type confirmed through clinical examination; having magnetic resonance imaging showing damage to the pyramidal system, without compromising the extrapyramidal system and cerebellum; age between seven and twelve years; GMFCS level one, two and three children; children who have sufficient strength to overcome gravity and complete the range of motion of the joint regarding the flexor and extensor muscles of the trunk, hips and knees; degree of spasticity less than three on the Modified Ashworth Scale; present degree of joint mobility of the ankle compatible with positioning in a neutral position, popliteal angle below thirty degrees and Thomas test with hip flexion below twenty degrees; consent of those responsible by signing the Informed Consent Form.	Children who are diagnosed with epilepsy or who have had seizures at least twelve months before the start of the study will be excluded; who have neurological, neuromuscular diseases or syndromes associated with brain injury; who have undergone orthopedic or neurological surgery in the twelve months prior to the intervention; who have undergone neurolytic blocks in the six months prior to the intervention; who have orthopedic deformities with surgical indication; who have brain implants or who have undergone a neurosurgical procedure; who have metallic implants in the head, neck, chest and / or upper limbs regions; who have hearing aids; children with a degree of collaboration incompatible with adequate performance in the activities proposed in this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-9syxzh3	Effect of Transcranial Electrical Stimulation and Intensive Physical Therapy in Cerebral Palsy	Data analysis completed	Intervention	2026-03-27	<NULL>	<NULL>	9024	Effect of Transcranial Direct Current Stimulation and Intensive Physical Therapy in Spastic Diparetic Cerebral Palsy	<NULL>	n/a, n/a, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-10	Departamento de Ciências do Movimento Humano da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Adolescent diagnosed with spastic diparetic cerebral palsy; ability to understand and follow simple instructions; availability to participate in all intervention and assessment sessions; absence of medical contraindications for undergoing transcranial direct current stimulation.	Presence of other neurological conditions that may affect the evaluation of results; presence of metallic implants or electrical devices in the skull that may interfere with the use of tDCS; history of uncontrolled seizures.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-2pd933q	Effect of Transcranial Magnetic Stimulation (TMS) associated with speech-language pathology treatment in patients with difficulty swallowing after a stroke	Not yet recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8620	Non-invasive brain stimulation in neurological conditions	<NULL>	n/a, n/a, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Stroke less than 3 months ago; both genders; Rankin scale less than 04; presence of oral communication and/or swallowing disorders; diagnosis of some neurological condition; age over 18 years	Require respiratory support; having magnetic material in the skull or a cardiac pacemaker; epilepsy or a history of seizures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-2md8855	Effect of Transcranial Neuromodulation (TN) associated with a program based on meditation on the pain of women with Migraine	Not yet recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7055	Effect of Transcranial Magnetic Stimulation (TMS) associated with a program based on Mindfulness meditation on the pain of women with Migraine: a feasibility study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-20	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-2md8855	<NULL>	Women (cis or trans). Aged between 18 and 65 years old. Present a diagnosis of Migraine according to the criteria of The International Classification of Headache Disorders (ICHD-3) 2018, for more than 3 months: at least five attacks meeting criteria from B to D; headache attacks lasting 4-72 hours (without treatment or with ineffective treatment); the headache has at least two of the following characteristics: unilateral location, pulsatile character, moderate or severe pain intensity, exacerbated by or causing the individual to avoid routine physical activities (for example: walking or climbing stairs); during headache, at least one of the following: nausea and/or vomiting, and photophobia and phonophobia, not better explained by another ICHD-3 diagnosis	Participants who are at a peak of cardiovascular disease or have severe cardiopulmonary disease. With sequelae of neurological diseases. Use walking aids. With visual and hearing impairments. With amputations of lower and upper limbs. With rheumatic diseases in the acute phase. Cancer. Epilepsy. Fractures of the skull, neck or rib cage. Severe osteoporosis. People with a pacemaker or implantable cardioverter defibrillator, epilepsy or who underwent surgery less than 1 year ago. Pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-24shfp	Effect of transcranial stimulation after stroke	Recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3942	Effect of transcranial electrical stimulation on locomotion and balance after stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-20	Universidade Federal do Triangulo Mineiro	Universidade Federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-24shfp	<NULL>	Patients with a diagnosis of stroke for at least 3 weeks and at most 1 year will be included; both genders; over 18 years; able to walk without assistance for 10 minutes without interruption.	Presence of metal in the cranial cavity; scalp lesions; use of a pacemaker; joint deformity in lower limbs or upper limbs; previous skull surgery; use of medications that interfere with cortical excitability; uncontrolled epilepsy; severe cognitive impairment; global aphasia; visual disturbances; other neurological diseases and pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-10w787j6	Effect of Transcranial Stimulation and Aerobic Training in patients with Heart Failure on physical capacity and inflammatory profile	Not yet recruiting	Intervention	2023-04-04	<NULL>	<NULL>	6274	Effect of Transcranial Direct Current Stimulation associated with Aerobic Training in patients with Heart Failure on physical capacity and inflammatory profile: controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-08	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-10w787j6	<NULL>	Patients aged over 18 years; Both sexes; Ejection fraction (EF) below 40%; Functional class II or III according to NYHA (New York Heart Association); Who are on optimized clinical treatment	Orthopedic dysfunctions that prevent physical exercise (such as, for example, osteoarthritis in the lower limb and/or spine); Neurological and/or cranial alterations that prevent the application of tDCS (Transcranial Direct Current Stimulation); Diagnosed seizures; Unstable angina symptoms; Patients using a pacemaker or implantable ventricular defibrillators; Metabolic syndromes linked to thyroid or liver; Body mass index (BMI) less than 18.5 and greater than 34,9; Patients with less than 3 months of cardiac decompensation; Patients undergoing cardiovascular rehabilitation in the last 12 months; Patients with cognitive disorders, assessed by the Mini Mental State Examination (MMSE) with a lower score in their education category; Uncontrolled diabetes, systemic arterial hypertension and dyslipidemia; Diagnosed lung disease, such as exercise-induced asthma and pulmonary fibrosis; Pregnant women; Smokers; Alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-72n9y83	Effect of Transcranial Stimulation associated with Speech Therapy on swallowing in the acute phase of Stroke	Recruitment completed	Intervention	2023-04-13	<NULL>	<NULL>	6002	Effect of Transcranial Direct Current Stimulation associated with Speech Therapy on Swallowing in the acute phase of Stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-20	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-72n9y83	<NULL>	Patients diagnosed with ischemic stroke for a maximum of 72 hours (acute phase) will be included; confirmed by computed tomography or magnetic resonance imaging; after neurological evaluation; of both sexes; over the age of 18 years; with dysphagia	Individuals with great swallowing impairment before stroke were excluded; previous episodes of stroke; previous dysphagia; associated neurological pathologies; any metal in the cranial cavity; lesions in the area of electrode placement (some skin change in the scalp in the area to be stimulated); metal in use of pacemaker; previous skull surgery; eyes or decompression surgery; use of medications that interfere with cortical excitability (opiates; benzodiazepines); score above 8 on the hospital scale of anxiety and depression (HAD); uncontrolled epileptic seizure; in addition to clinical instability (systolic blood pressure; drop in systolic blood pressure; heart rate; altered consciousness; cold and sticky skin);  severe cognitive impairment; global aphasia; previous visual disturbances; ; other associated neurological diseases or possibility of pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-397qws	Effect of Transcutaneous Electric Nerve Stimulation (TENS) in delayed onset muscle soreness (DOMS): prevention and treatment	Data analysis completed	Intervention	2018-01-08	<NULL>	<NULL>	1558	Effect of TENS in Delayed Onset Muscle Soreness (DOMS): prevention and treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-05	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-397qws	<NULL>	Healthy; physically inactive volunteers; both sexes; aged 18 to 40 years.	Previous experience with the use of TENS; muscoloskeletal disorders; heart diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-6hmh7w	Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Migraine	Recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3411	Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Migraine: Randomized Clinical Trial Placebo-Controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-15	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6hmh7w	<NULL>	Patients diagnosed with chronic aura and non-aura migraine headache, with pain intensity equal to or greater than 4 on the numerical pain scale, both sexes and aged 18 to 59 years.	Other dysfunctions with headache symptoms, history of head and neck trauma, cardiac pacemaker use, and have already used TENS. Also, if they are undergoing another type of physical therapy treatment or are starting a new medicine treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-2gfygv	Effect of transcutaneous electrical nerve stimulation on postoperative pain in patients after surgical treatment of distal radius fracture.	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2349	Physiotherapeutic treatment of patients after radio-distal fracture during the hospital and outpatient phases.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal do Triângulo Mineiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2gfygv	<NULL>	"Age greater than 18 years;
Both sexes, female or male;
Subjected to distal radio-fracture surgery with internal fixation that are hospitalized at the UFTM Clinical Hospital;
With postoperative pain complaint;
Ability to respond to assessment;
Ability to sign the TCLE;
Absence of: neurovascular lesions; pregnancy or lactation; severe arrhythmia and use of cardiac equipment; history of epilepsy; severe medical illness, such as uremia, decompensated liver cirrhosis and cancer; psychosis unable to cooperate; and experience with TENS."	"To present dehiscence or infection in the surgical incision with exposure of the injured skin;
New surgery during the period of intervention or death;
Neurovascular lesions diagnosed after hospital intervention;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-4qjdxq	Effect of transcutaneous electrical nerve stimulation on the neurogenic bladder and bowel in children with neurological dysfunctions	Recruiting	Intervention	2018-10-22	<NULL>	<NULL>	2292	Effect of Parasacral Neuromodulation on the neurogenic bladder and bowel in children with neurological dysfunctions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Instituto Santos Dumont	Instituto Santos Dumont	https://ensaiosclinicos.gov.br/rg/RBR-4qjdxq	<NULL>	"Children between 2 and 18 years of age.
Children diagnosed with neurogenic bladder and bowel due to myelomeningocele."	"Lack of fundamental information in the medical records (complementary image and developmental data).
Children with non-drained / controlled hydrocephalus.
Children who have uncorrected spinal cord.
Miss 2 times to the meeting with the physiotherapy.
Do not complete 12 weeks of home treatment.
Do not adhere to treatment.
Have undergone sacral neuromodulation treatment in the last year or initiate other concurrent therapeutic modalities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-2tycqw	Effect of Transcutaneous Electrical Stimulation on the cardiovascular behavior of Healthy Individuals when standing	Recruiting	Intervention	2020-10-29	<NULL>	<NULL>	4352	Effect of Ganglionic Transcutaneous Electrical Stimulation on the Autonomic Modulation of Healthy Individuals during Orthostatism	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-25	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-2tycqw	<NULL>	Healthy individuals of both sexes; between 18 and 40 years old and sedentary; matched for age and body mass index; will be invited to participate in the study.	Exclusion criteria will be: use of regular medication (except contraceptives); cardiometabolic diseases, pregnancy; patients with pacemakers or implantable cardioverter defibrillators	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-34fjqk	"Effect of Transcutaneous Nerve Electrical Stimulation in the System
Autonomic cardiovascular autonomic of patients with fibromyalgia: a study
randomized"	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4179	"Analysis of the Effect of Transcutaneous Nerve Electrical Stimulation in the System
Autonomic cardiovascular autonomic of patients with fibromyalgia: a study
randomized"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-11	Universidade Federal de Sergipe	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-34fjqk	<NULL>	Patients with fibromyalgia evaluated according to the classification criteria of the American College of Rheumatology; female; aged between 18 and 60 years; sedentary;  no cardiovascular diseases.	"Neurological and rheumatic diseases associated with FM; any other characteristic that
maintenance of electro-stimulation; current intolerance; electrode allergy; any skin contact material; presence of
pacemaker; pregnancy; other absolute indication."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-5twbsm	Effect of transcutaneous nerve electrostimulation (TENS) during bodybuilding exercise in the control of pain and physical performance of healthy adults	Recruitment completed	Intervention	2017-07-12	<NULL>	<NULL>	1291	"Effect of transcutaneous nerve electrostimulation (TENS) during exercise
In the control of pain and in the physical performance of healthy individuals"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-05	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5twbsm	<NULL>	The sample will consist of healthy; university students; of both sexes; aged 18 and 40; who will be recruited on São Cristóvão campus of Federal University of Sergipe; through personal contacts with them on campus facilities and dissemination by email; irregularly active; and have not performed resistance training of the muscles of the upper limbs for two months prior to the survey. The short version of the international physical activity questionnaire (IPAQ), validated in portuguese, will be used to ensure the eligibility of the sample.	They have any musculoskeletal, cardiovascular, neurological or systemic disorder that can be exacerbated by strenuous exercise (eg, recent injury; chronic pain; heart disease). Potential medical contraindications for the study of exercise protocol will be further evaluated using a questionnaire prepared by the author, based on the physical activity readiness questionnaire (PAR-Q, 2011). The subjects who have had some experience with TENS or any contraindication to prevent the use of electrical stimulation, such as allergy to the material of the electrodes; cardiac pacemaker use; pregnancy; epilepsy; altered skin conditions or loss of feeling in areas established for electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-7rc2t5j	Effect of Transcutaneous Radiation in Hypertensive Patients: Application to the Radial Artery	Recruitment completed	Intervention	2024-12-16	<NULL>	<NULL>	7595	Effectiveness of Photobiomodulation in Hypertensive patients: transdermal application in radial artery	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Instituto de Ciência e Educação de São Paulo	Instituto de Ciências e Tecnologia da Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7rc2t5j	<NULL>	Patients diagnosed with grade I and II hypertension according to the VII Brazilian Guideline for Arterial Hypertension; both sexes; age between 50 and 70 years; Body Mass Index (BMI) between 18 and 30 kg/m²; classified as slightly active and irregularly active according to criteria established by the International Physical Activity Questionnaire, short version (IPAQ); registered and monitored by the Family Health Strategy team, in the Hiperdia Program; residing in the city of Bocaina- PI; who are available to participate in the treatment plan and have preserved cognitive capacity	Patients with comorbidities or associated complications such as uncontrolled diabetes and dialysis patients; history of neoplasms; pregnant women; breastfeeding women; alcoholics; smokers;  electronic implants; patients temporarily away from home	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-38mzzg	Effect of treadmill training associated with auditory stimulation on gait and the ability to move of individuals with Parkinson&apos;s disease	Recruitment completed	Intervention	2016-07-01	<NULL>	<NULL>	904	Acute effect of treadmill training associated with auditory stimulation on gait kinematic parameters and functional mobility of individuals with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-38mzzg	<NULL>	Volunteers with Parkinson&apos;s disease; both genders; aged 60 to 85 years; independent walking.	Present other neurological diseases than Parkinson&apos;s disease; be in pharmacological adaptation phase; present pain; present fracture; present serious injury to soft tissues in the six months previous to the study; present history of cognitive, cardiovascular or respiratory changes untreated; not be able to understand verbal instructions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-8tbhyr	Effect of Treadmill Training on Treadmill and Video Game on the Balance and Walking of People with Parkinson&apos;s Disease	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1277	Effect of gait training and virtual reality on balance and gait in individuals with Parkinson’s disease: Protocol for a randomized, controlled, blind, clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Nove de Julho	Associação Brasil Parkinson	https://ensaiosclinicos.gov.br/rg/RBR-8tbhyr	<NULL>	Diagnosis of idiopathic PD in phase 1, 2 or 3 on the Hoehn and Yahr scale; Score ? 46 on Berg Balance Scale – BBS; Adequate vision (with or without glasses);  Adequate hearing (with or without a hearing aid).	Physical disability; Severe heart disease; History of seizure; Uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-4bcp54k	Effect of treatment with whole Grape Juice along with traditional treatment in patients hospitalized with covid19	Data analysis completed	Intervention	2021-09-06	<NULL>	<NULL>	4863	Evaluation of Grape Juice treatment on Systemic Inflammation, Oxidative Stress, Autonomic Neuromodulation and the impacts of these variables on the severity of progression of Covid19 (2019 coronavirus disease) in hospitalized patients	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-10-20	Empresa Brasileira de Serviços Hospitalares	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4bcp54k	<NULL>	Volunteers of both sexes over 18 years of age who had confirmed COVID-19 disease between October 20, 2020 and February 28, 2021, and who were functionally able to ingest food, in addition to agreeing to participate in the study by signing the Informed Consent Form	Patients who had difficulties in ingesting food during the study, died and/or did not undergo the final tests at hospital discharge, in addition to medical recommendations not to ingest the drink, were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-5kw3bz	Effect of tumeric extract supplementation on oxidative stress and inflammation after running	Data analysis completed	Intervention	2018-07-16	<NULL>	<NULL>	2014	Effect of Curcula longa L. supplementation on oxidative and inflammation markers after endurance exercise	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-08	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5kw3bz	<NULL>	Men, eutrophic, aged between 25 and 50 years, amateur runners	Participants on weight loss diet/medication, diagnose with any acute or chronic diseases, taking medication that could affect the immune system, injured, smokers, and with a history of chronic alcoholism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7tj48w	Effect of turmeric supplementation on oxidative stress and inflammatory markers after endurance exercise	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4165	Effect of Curcuma longa L. supplementation on oxidative stress and inflammatory markers after endurance exercise	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-02	Tatyanne Letícia	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7tj48w	<NULL>	Healthy men aged between 20 to 40 years; able to complete all study assessments	In the use of medications or nutritional supplements; alcoholic beverages; on a diet or dietary restriction; using turmeric as a condiment at meals in the last seven days before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-7drpyr	Effect of two covers to prevent injuries caused to professionals working in the health area due to the use of personal protective equipment	Recruitment completed	Intervention	2020-07-13	<NULL>	<NULL>	4007	Effect of two technologies in the prevention of pressure injuries associated with the use of personal protective equipment in health professionals in the face of the Covid-19 pandemic: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-20	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7drpyr	<NULL>	Professionals who provided direct assistance (doctors, nurses and physiotherapists) or indirect assistance (hygiene collaborators) to patients with suspected or diagnosed coronavirus; Professionals who needed to make continuous use (cap and particulate respirator) or intermittent use (face mask, gloves and apron) of PPE for six or 12 consecutive hours; Professionals who had no skin lesions on the face	Professionals who had some problem in sealing the N95 mask with the use of technology; Professionals who do not finish the shift; Professionals who needed to remove the cover due to discomfort or signs of allergy; Professionals who do not completely fill out the evaluation form received together with the LP prevention technology resulting from the use of PPE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-2cxrpp	Effect of Two Kinds of Therapy on Women with Patellofemoral Pain Syndrome	Recruiting	Intervention	2013-07-30	<NULL>	<NULL>	217	Effects of Lumbo-pelvic Stabilization Training on Women with Patellofemoral Pain Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-04	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-2cxrpp	<NULL>	Women agend between 18 and 30 years old, anterior or retropatellar knee pain during at least two of the folling activities: ascending/descending stairs, squating, running, jumping and prolonged sitting, insidious onset of the symptoms being unrelated to a traumatic incident and persistent for at least 8 weeks, presence of pain on palpation of the patellar facets, usual pain in the last week of at least 3cm in the Visual Analogue Scale (VAS) of 10cm.	Signs or symptoms of meniscal disorders, cruciate or collateral ligament involvement, tenderness over the patellar tendon, iliotibial band, or pes anserinus tendons, sign of patellar apprehension, Osgood-Schlatter or Sinding-Larsen-Johansson syndromes, hip or lumbar referred pain, history of patellar dislocation, evidence of knee joint effusion, previous surgery on the knee joint.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-10qgbdg3	Effect of Two Procedures for Dressing the Roof of the Mouth Evaluating Pain, Quality of Life and Healing in People Who Underwent Gum Grafting	Not yet recruiting	Intervention	2024-04-28	<NULL>	<NULL>	6974	Effect of different protective interventions of the palatal donor area on Healing, Pain and Quality of Life of individuals undergoing Epithelized Free Gingival Grafts: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal de Minas Gerais (UFMG)	Universidade Federal de Minas Gerais (UFMG)	https://ensaiosclinicos.gov.br/rg/RBR-10qgbdg3	<NULL>	Individuals aged 18 or over; systemically healthy or controlled American Society of Anesthesiologists (ASA) (ASA I / ASA II); with minimum palatal tissue thickness 2mm assessed with a University of North Carolina (UNC) periodontal probe; both genders	Smokers and alcoholics; individuals with altered coagulation, i.e., history of hemophilia, von Willebrand disease, or currently undergoing anticoagulant therapy; individuals with altered healing patterns, that is, decompensated type 2 Diabetes Mellitus; pregnant and breastfeeding women; individuals with a history of bacterial endocarditis; with continuous use of anti-inflammatories and corticosteroids; individuals who underwent gum grafting in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-37gw2x	Effect of two therapeutic modalities on chronic hip pain	Recruiting	Intervention	2019-09-30	<NULL>	<NULL>	3913	Randomized clinical trial: Effect of a physiotherapeutic protocol in greater trochanteric pain syndrome in women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Estadual Paulista, Faculdade de Filosofia e Ciências	Universidade Estadual Paulista, Instituto de Biociências	https://ensaiosclinicos.gov.br/rg/RBR-37gw2x	<NULL>	Being female. Volunteers must be between 25 and 70 years old. Present pain and chronic lateral tenderness in the hip greater than or equal to 3 months. Pain in at least 1 of the 7 provocative pain tests which is intended to transmit compressive or tension forces in the hip abductor muscles tendons. Do not engage in regular physical activity and present comparable demographic data between groups.	Present body mass index greater than 36kg / m2. Have received some type of invasive intervention to reduce pain in the evaluated region in the last year. Physical therapy intervention in the last 3 months. Present limitation in the range of motion of the spine and hip or lower limbs that disables gait. Present limitation in the range of motion that disables tests or training. Any disease that affects the neuromuscular system or that may prevent data collection. Spinal or hip surgery. Any infectious or neoplasic condition. Can not compromise with the weeks of training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-2br4cwp	Effect of two types of Shoulder Stretching on pain and mobility in Symptomatic Athletes	Not yet recruiting	Intervention	2022-09-08	<NULL>	<NULL>	5597	Effect of Posterior Shoulder Capsule Stretches in symptomatic overhead athletes with Internal Rotation Deficit: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-26	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2br4cwp	<NULL>	Overhead athletes aged between 18 and 40 years; competitive level; difference of at least 20 degrees of limitation in internal rotation compared to the non-dominant limb; pain in activities of daily living or sports at least 2 on the Visual Numerical Scale. Athletes with a previous history of glenohumeral instability; shoulder surgery; current symptoms related to the cervical spine; or structural injuries to the shoulder complex such as a fracture; labrum or tendon injuries will not be included	Athletes who injure their shoulder and/or elbow during the study; refusal to participate in study interventions and evaluations after randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-4xxwwj	Effect of Unripe Banana Flour on gut and uremic compounds in patients on Peritoneal Dialysis	Recruitment completed	Intervention	2018-12-20	<NULL>	<NULL>	2824	Effect of Unripe Banana Flour on gut microbiota and uremic toxins in patients on Peritoneal Dialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-10	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-4xxwwj	<NULL>	3 months or more in peritoneal dialysis; adherence to dialysis treatment.	Use of prebiotics, probiotics, synbiotics and antibiotics within the previous 30-day period at the beginning of the study; Crohn&apos;s disease or ulcerative colitis; severe hepatic disease; cancer; serum positive for the Human Immunodeficiency Virus (HIV); peritonitis or infection at the exit site; stomach or bowel resection; pregnancy or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-3n2f38	Effect of using a Mobile Application for foot Care of people with Diabetes	Not yet recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1442	Multimedia Application on Mobile Platform to Promote foot Care for people with Diabetes: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Estadual do Ceará - UECE	Universidade Estadual do Ceará - UECE	https://ensaiosclinicos.gov.br/rg/RBR-3n2f38	<NULL>	Be 18 years of age or over; having a medical diagnosis of type 2 diabetes mellitus; be accompanied by the Integrated Diabetes and Hypertension Center; possession of a mobile device for personal use android smartphone; ability and familiarity with application usage.	Persons with apparent diseases and conditions with marked functional dependence; cognitive deficit or any difficulty that impedes the handling of the device and responses to the instrument; and present pre-existing diabetic ulcer. Discontinuity criteria: non-attendance at the study stages; illness or death during the course of the study; giving up and not answering calls. Three attempts of interleaved contacts will be made.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-5zx8rvc	Effect of using a mobile application on the knowledge and self-care of people with heart failure	Recruitment completed	Intervention	2024-03-19	<NULL>	<NULL>	6868	Effect of a mobile application on the knowledge and self-care of people with heart failure: a quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5zx8rvc	<NULL>	Eligible individuals were those who met the following criteria: patients diagnosed with Heart Failure, aged 18 years or older; in follow-up, with a smartphone with Android operating system; taking medication; who had adequate health literacy, according to the Eighth-item Health Literacy Scale (19 points); and oriented in time and space. In order to evaluate the orientation of individuals, the following questions were asked: What is your name? How old are you? What day, month, year and location are we in? What city do you live in?	individuals who, due to clinical decompensation, resulted in previous hospitalization in the last 30 days; who were listed on the heart transplant queue and individuals planning myocardial revascularization or interventional procedure such as Transcatheter aortic valve implantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-76w7cj	Effect of using a new Instrument XP-Endo Finisher in Root Canal Treatment	Recruiting	Intervention	2018-07-09	<NULL>	<NULL>	2910	Effect of the XP-endo Finisher Instrument on the reduction of Periapical Lesions in posterior teeth: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-76w7cj	<NULL>	Any individual presenting with posterior teeth with a clinical picture of pulp necrosis and radiographic evidence of apical periodontitis, presenting lesions greater than 2 mm in diameter;Agree to participate and sign the informed consent form	"Teeth with great coronary destruction, requiring prosthetic rehabilitation; Present any pre-existing general and / or oral clinical condition that puts the individual at risk during the study;
Being pregnant or breastfeeding; Patient with generalized periodontal disease or affecting the tooth that needs endodontic treatment; Allergic reaction to chemicals used in endodontic treatment;Teeth that do not present complete root formation - incomplete rhizogenesis; Teeth that present radiographic evidence of internal or external root resorption; Teeth whose root canal is calcified; Teeth submitted to previous endodontic treatment; History of antibiotic use prior to treatment; or need for antibiotic prophylaxis (eg bacterial endocarditis); Teeth that present vital pulp tissue, even if radiographically there is presence of radiolucent image associated with the periápice; Teeth that, during the endodontic treatment, show signs of root fracture; When, during the endodontic procedure, accidents and complications occur, specifically root perforations and instrument separation within the SCR; Patients who do not return to reassessment appointments"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-33m2tb8	Effect of using a Nursing Care Protocol on a person with an amputation due to Diabetes Mellitus	Not yet recruiting	Intervention	2023-04-20	<NULL>	<NULL>	6029	Effect of using a Nursing Care Protocol on people with Amputations due to Diabetic Complications: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Estadual da Paraíba - UEPB	Universidade de Pernambuco - UPE	https://ensaiosclinicos.gov.br/rg/RBR-33m2tb8	<NULL>	Be 18 years of age or older; present amputation due to diabetic complications; being treated in the inpatient units of the hospitals participating in the study	Patients admitted to the Intensive Care Unit; presenting a medical diagnosis of neurological deficit that hinders the learning process; have hearing and/or visual impairment; Health professionals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-10b2vr39	Effect of using Supplements with Immunomodulatory Nutrients in the preoperative period of Major Surgeries	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7719	Effectiveness of using an Immunomodulatory Formula in the preoperative period of Major Surgeries	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-01-05	Faculdade de Nutrição Emília de Jesus Ferreiro	Faculdade de Nutrição Emília de Jesus Ferreiro	https://ensaiosclinicos.gov.br/rg/RBR-10b2vr39	<NULL>	Individuals aged between 20 and 80 years; of both sexes; candidates for major elective surgeries followed on an outpatient basis at the Antônio Pedro University Hospital of the Fluminense Federal University (HUAP/UFF)	Participants will be excluded if they: cannot use the gastrointestinal tract as a feeding route during the study period; have amputated limbs; have previously consumed source foods or dietary supplements containing arginine, omega 3 and/or nucleotides on a regular basis, and/or in a dose and time different from that estimated by this study; have a history of allergy to cow&apos;s milk protein, fish and soy or lactose intolerance; have previously used probiotics, symbiotics or antibiotics during the last 2 months prior to the perioperative period; are in a condition of pregnancy or lactation; have severe organic dysfunctions (carriers of cardiovascular diseases, chronic kidney disease and neurodegenerative diseases); have received postoperative immunomodulatory enteral supplementation in a dose and time different from that stipulated in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-74wcnjc	Effect of using the Peanut Ball on labor: a randomized clinical trial	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5024	Effects of an exercise protocol with the aid of a peanut ball during labor without analgesia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-74wcnjc	<NULL>	Pregnant with single gestation; above 37 weeks; fetal cephalic presentation; usual gestational risk; over 18 years of age	Volunteers who present some complication during labor; admitted for labor induction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-9v9gx9s	Effect of using Toothpastes with Desensitizers on reducing Tooth Sensitivity and Quality of Life in adults with previous sensitivity after dental bleaching	Data analysis completed	Intervention	2024-03-12	<NULL>	<NULL>	6851	Effect of using Toothpastes with Desensitizers on reducing Tooth Sensitivity and Quality of Life in adults with previous sensitivity after in-office dental bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9v9gx9s	<NULL>	Individuals dissatisfied with the color of their teeth and with good oral health;  anterosuperior teeth with vitality, free of cavities and restorations on the vestibular surface; upper central incisors with coloration equal to or darker than A2, according to the Vita Classical color scale; stimulated or provoked dentin sensitivity in any superior superior premolar, canine and incisive	Severe intrinsic stains on the teeth (such as tetracycline or fluorosis); active periodontal disease;  use of any anti-inflammatory, analgesic and antioxidant action drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-2hpkp3	Effect of vaginal contraction exercise in bladder control in women with multiple sclerosis and neurological disease caused by the virus HTLV1	Recruiting	Intervention	2017-07-19	<NULL>	<NULL>	1298	Pelvic floor training in the treatment of lower urinary tract symptoms in women with Multiple Sclerosis (MS) and HLTV-I associated Myelopathy (HAM / TSP): A randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-10	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2hpkp3	<NULL>	"Women with diagnosis defined in Multiple Sclerosis, in the relapsing remitting form
And with the disease stabilized for at least four months, EDSS score less than or equal to 6.5. Or women with a diagnosis defined in HAM / TSP, with more than 18 years of age with HTLV - 1 positive ELISA and confirmed by Western blot (HTLV Blot 2.4), with urological and neurological evaluation, Osame Motor Scale dysfunction OMSS) and score in the lower EDSS equal to 6.5.
Aged over 18years, cognitive ability to respond to evaluation questionnaires and treatment protocol, presenting symptoms of urinary dysfunction for at least six months (at least three of the following: urgency,
Urge incontinence, high voiding frequency, nocturia and nocturnal enuresis), with no history of previous treatment with pelvic floor exercises, those that will not present genital prolapses
Or history of previous gynecological surgeries that are not pregnant, with no history of vaginal delivery or cesarean section within a period of less than six months prior to the start of the study, as well as those who will be out of menopause and without urinary infection excluded by laboratory examination."	Pregnant women with Diabetes mellitus, indigenous ethnicity and or quilombola, under the age of 18. Women who present exacerbation of symptoms or outbreak during the course of treatment, those who can not attend the treatment and refuse to perform the proposed treatment or voluntarily give up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-3j3mkjt	Effect of Vaginal Estrogen cream in patients with Cervical Cancer treated with Radiotherapy	Recruitment completed	Intervention	2025-08-21	<NULL>	<NULL>	8223	Effect of Topical Estrogen on the vaginal epithelium of patients with Cervical Cancer treated with Radiotherapy: a randomized pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-21	Instituto de Medicina Integral Professor Fernando Figueira	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-3j3mkjt	<NULL>	"Women aged between 18 and 55 years; Histological diagnosis of cervical carcinoma stages I to IIIc2;
Radiotherapy treatment including external beam radiotherapy with a total dose used between 45 and 50.4Gy and brachytherapy with a total dose used between 24 and 28Gy; No personal history of neoplasia, except non-melanoma skin"	Women with comorbidities that contraindicate the use of vaginal estrogen; Patients undergoing surgical treatment for cervical cancer; Persistent disease on gynecological examination after the thirtieth day after the end of radiotherapy treatment; Histological diagnosis of small cell cervical cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-7bb6mhc	Effect of Vaginal Laser in menopause: a comparative study on Genitourinary Symptoms	Data analysis completed	Intervention	2025-02-14	<NULL>	<NULL>	7750	Genitourinary Syndrome of menopause in patients treated with Vaginal CO2 Laser: a randomized clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7bb6mhc	<NULL>	Healthy postmenopausal women (at least 12 months since their last menstrual period, or with bilateral oophorectomy, or hysterectomized with follicle-stimulating hormone higher than 40 U/L; estradiol lower than 25 pg/mL); negative oncotic colpocytology within the last year; who agree to participate in the study and sign the informed consent form (ICF)	Active or recent (&lt;15 days) vaginal lesions; use of hormone replacement therapy in the last 6 months; untreated genitourinary tract infections; abnormal uterine bleeding; history of photosensitivity disorder or use of photosensitizing drugs; grade II-III genital prolapse (according to the Pelvic Organ Prolapse Quantification system, POP-Q); bacterial or viral vaginal infection (HPV, Herpes); immunosuppression; chronic corticosteroid use; scleroderma; extensive prior radiotherapy; burns in the area; collagen disorders; pregnancy and breastfeeding; genital neoplasia; anticoagulant therapy; patients with sling/mesh; uncontrolled diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-95p3jgp	Effect of Vagus Nerve Electrostimulation on Heart Rate Variability	Recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7741	Effect of different frequencies and laterality of Transcutaneous Vagus Nerve Stimulation on Heart Rate Variability: a randomized crossover study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-08	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-95p3jgp	<NULL>	Healthy volunteers; both genders; non-smokers; aged between 18 and 40 years; able to read and write Brazilian Portuguese sufficiently to complete the data collection instruments	Volunteers who smoke; history of alcohol or drug abuse; diagnoses of heart disease, hypertension, suspected or confirmed pregnancy, cognitive changes that make it impossible to collaborate in the intervention and data collection, injuries to the auricle or absence of the auricle	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-8k54cz	Effect of vagus nerve stimulation and physical exercise on cardiovascular, metabolic and cognitive responses in people with HIV	Recruitment completed	Intervention	2020-07-09	<NULL>	<NULL>	3994	Effect of Auricular Transcutaneous Electrostimulation of the Vague Nerve and Physical Exercise on the cardiovascular, metabolic and cognitive parameters of people living with HIV / AIDS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8k54cz	<NULL>	Individuals will need to present a medical certificate clearing the practice of physical exercise, be aged between 18-60 years, present a number of TCD4 lymphocyte cells equal to or above 350 cells / mm³ of blood and enroll as participants in the “VIVER +” project.	Individuals who do not have conditions to carry out the protocol and the evaluations during the research, have opportunistic injuries or infections, have undergone cardiac surgery or have heart disease, are currently dependent on illicit drugs, have serious medical disorders and / or have less than 75% will be excluded. attendance at physical exercise sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-3xqd5yz	Effect of Vagus Nerve Stimulation in women with Fibromyalgia	Recruiting	Intervention	2024-11-08	<NULL>	<NULL>	7495	Effect of Transcutaneous Auricular Vagus Nerve Stimulation in women with Fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-3xqd5yz	<NULL>	Female individuals; age between 18 and 65 years old; patients with fibromyalgia; walk independently; understand brazilian portuguese	IIndividuals with red flags like fracture or cancer; suspected or confirmed pregnancy; unstable heart conditions; absence of ear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-10d3crcf	Effect of Vagus Nerve Stimulation on Fibromyalgia	Recruiting	Intervention	2021-03-05	<NULL>	<NULL>	6072	Effect of Stimulation of the Auricular Branch of the Vagus Nerve on Fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10d3crcf	<NULL>	"Female individuals who meet the following criteria will be included in the sample: age between 18 and 65 years; diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology (ACR); pain equal to or greater than 3 points (END);
being able to walk independently, with or without assistance; understand the Brazilian Portuguese language well enough to complete the questionnaires.

10 healthy female subjects, aged between 18 and 65 years, will also be included, who can understand the Brazilian Portuguese language well enough to complete the questionnaires."	Individuals who meet the following criteria will be excluded from the study: presence of red flags such as fracture, malignancy / cancer, or pathologies that justify the presence of pain and inflammation; suspected or confirmed pregnancy; cognitive changes; unstable heart conditions; auricular lesions or absence of it.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-5zy6vw	Effect of varicocele correction surgery on the quality of sperm	Recruiting	Intervention	2015-06-24	<NULL>	<NULL>	526	"Varicocelectomy effect on the spermatic DNA fragmentation: clinical trial
with random assignment of participants"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-10	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5zy6vw	<NULL>	Men with varicocele in grades II and III; aged between 18 and 45; not having undergone previous varicocelectomy.	Smoking; excessive use of alcohol; drug abuse; genetic damage; prior varicocele correction surgery; testicular trauma; urogenital infections suspicion; cancer; endocrinopathies; treatments that may influence the testicular functions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-4488twr	Effect of Vascular Occlusion on Muscle Damage caused by Physical Exercise	Not yet recruiting	Intervention	2021-06-02	<NULL>	<NULL>	4718	Effect of Ischemic Preconditioning on Muscle Damage Induced by Resistance Training	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-20	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4488twr	<NULL>	"Male gender;
Age range between 18-34 years;
Do not practice systematic physical exercise in the previous six months;
Absence of diseases / injuries that make physical exercise impossible;
Normal blood pressure values at rest and ankle-arm index (ABI).
Absence of risk factors for thromboembolism;
Do not make chronic use of medication / dietary supplement with anti-inflammatory / antioxidant action"	"Failing to complete the planned interventions;
Use some type of medication with anti-inflammatory properties during the 72 hours after interventions;
Come to exercise during the 72 hours after interventions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-2qpyxf	Effect of vascular occlusion training on muscle and clinical outcome of patients admitted to the intensive care unit	Recruiting	Intervention	2020-01-21	<NULL>	<NULL>	4375	Effect of blood flow restriction training on muscle changes and prognosis in intensive care unit patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Programa de Pós-graduação em Fisioterapia da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-2qpyxf	<NULL>	Forty comatose patients admitted to the Adult Intensive Care Unit (ICU) of Santa Casa de Misericórdia de São Carlos will be included in the study. Inclusion criteria will be individuals aged 18 to 60 years (BARBALHO et al., 2018; DIRKS et al., 2015); Ramsay sedation scale with a score of 6 to 4 (DE JONGHE et al., 2000) or a score of 3 to 6 on the Glasgow coma scale (REITH et al., 2016) and with daily protein intake standardized by ICU medical and nutrition team (BARBALHO et al., 2018).	Obese patients (body mass index greater than 30 kg / m²); with more than one risk factor for venous thromboembolism (ANDERSON; SPENCER, 2003); using vasoactive drugs; fever; anemia; thrombocytopenia and neurodegenerative and musculoskeletal diseases will not be included in the research. Persistent arrhythmias such as atrial fibrillation; pre-existing atrioventricular block or ventricular tachycardia; recent acute myocardial infarction; provisional or definitive pacemaker; signs of intracranial hypertension; neoplasia under chemotherapy treatment and unconsolidated fracture will be considered criteria for non-inclusion in the study (GEROVASILI et al., 2009).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-36d8nf	Effect of vibration stimulus in fibromyalgia women	Recruitment completed	Intervention	2016-09-09	<NULL>	<NULL>	991	Acute effect of whole body vibration in neuro endocrine inflammatory parameters in fibromyalgia women	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-30	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Fundação de Amparo à Pesquisa de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-36d8nf	<NULL>	"Fibromyalgia: present confirmed diagnosis of fibromyalgia by rheumatologist. According to the American College of Rheumatology for the characterization of the disease, the symptoms must persist for at least 3 months.
Control: not present rheumatic disease or serious general health changes and not be inserted in any physical activity program. These women were selected paired form (1:1) according to age and anthropometric variables with fibromyalgia group."	being a smoker; drinking alcohol; make use of immunosuppressive medication; present any concomitant disease that can be exacerbated by physical activity; pregnancy; orthopedic impairments; respiratory and inflammatory diseases or cardiovascular diseases; be followed up with a psychiatrist, or perform physical activity for the same 2 times a week; Acute hernia; thrombosis; epilepsy; orthopedic injuries; prostheses. The above criteria were used for both groups.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-65pmwy	Effect of Vibration treatment in women with Urine Loss on exertion	Recruiting	Intervention	2020-03-10	<NULL>	<NULL>	4178	Effect of whole body Vibration on pelvic floor muscles in women with Stress Urinary Incontinence: a randomized double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-65pmwy	<NULL>	women with stress urinary incontinence and who are not undergoing any other physiotherapeutic treatment for urinary loss at the time of the research.	Patients with pacemakers or cardiac implants; metallic grafts; acute urinary tract infection; epilepsy, decompensated hypertension, BMI above 40 kg / m2; with a physical disability that unable to receive the intervention or the assessment tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-3g22mg	Effect of video for grandparents in the promotion of breastfeeding	Not yet recruiting	Intervention	2018-06-14	<NULL>	<NULL>	1898	Effect of the use of educational technology for grandparents in the promotion of breastfeeding	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3g22mg	<NULL>	Grandparents whose firstborn daughters or daughters-in-law are in the third trimester of pregnancy will be included and regularly perform prenatal consultations by registered nurses, who are literate and plan to breastfeed their babies.	Grandparents whose daughters, daughters-in-law or grandchildren present some condition known to contraindicate breastfeeding and those with risk pregnancies will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-7y6f3j	Effect of video game training and conventional physiotherapy on improving the balance of the elderly	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1791	Effects of Cognitive Motor Training in real and virtual environments on postural control of the elderly: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7y6f3j	<NULL>	Community dwelling elderly individuals, aged 65 years or over; of both sexes; with a functional state capable of remaining standing, and walking without assistance; without cognitive impairment in the Mini-Mental State Examination89 (&lt;18 for illiterate individuals and &lt;26 for those with an educational level greater than 8 years); normal or corrected hearing acuity (Whisper Test)90; normal or corrected visual acuity (Snellen)91; with no prior experience with the games of the system; and who sign the Free and Clear Informed Consent.	Neurological and orthopedic diseases; the inability to remain in a standing position or walk without assistance; cardiorespiratory diseases that result in clinical alterations; angina; cardiac insufficiency; decompensated blood pressure; behavioral alterations that interfere with the development of the study; incapacitating pain; a history of seizures; and missing more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-77h2pr	Effect of video games on rehabilitation in patients in the burn therapy unit in sergipe	Data analysis completed	Intervention	2018-08-23	<NULL>	<NULL>	2143	Effects of virtual reality in patients of the therapy of the therapy unit of Sergipe burns.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-77h2pr	<NULL>	Patients with burns 2nd and 3rd grades in the thorax and upper limbs, which are hemodynamically stable, suitable for rehabilitation in terms of cognitive ability to follow simple commands, have normal or corrected vision and hearing with the use of orthoses.	Patients with sequelae of central and peripheral burns, encephalopathies, fractures, muscular distension, psychiatric disorder, use of artificial airway and mechanical ventilatory support.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-6rc23h	Effect of violet light on in-office dental bleachings: 12 months follow-up	Data analysis completed	Intervention	2020-08-25	<NULL>	<NULL>	4164	Dental bleaching using violet LED associated or not with 37% carbamide peroxide: a randomized double-blinded clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-21	Faculdade de Odontologia de Bauru - USP	Faculdade de Odontologia de Bauru - USP	https://ensaiosclinicos.gov.br/rg/RBR-6rc23h	<NULL>	Sign the consent form; availability to attend all sessions; age between 18 and 35 years; good health, controlled blood pressure, and adequate oral hygiene; pulp vitality in the teeth to be bleached (1st PM on one side to 1st PM on the opposite side in the upper and lower arches); color of teeth above A2 on the VITA scale, visually identified.	Smoker; pregnant or lactating; heart problems; history of known reaction to peroxides; individual or family history of neoplasia in the oropharynx region and surroundings; history of diabetes or other systemic diseases, which can interfere with the access of tissues from the oral cavity; need antibiotic therapy before dental prophylaxis; presence of oral pathologies, xerostomia, caries lesions, extensive restorations of composite resin, fractures or splinters in the teeth, gingivitis/periodontitis, bruxism, which in the professional&apos;s opinion may compromise the participant&apos;s health or the results of the study; presence of surface irregularities, tetracycline stain, discoloration due to trauma, fluorosis, hypoplasia, dental implant, prosthesis and/or endodontic treatment in upper or lower anterior teeth, or other parameters that may make it difficult to measure tooth color; have made use of bleaching agents in the office or at home in the last year (does not include toothpaste or bleaching mouthwash); spontaneous tooth sensitivity; intention to put a fixed orthodontic appliance during the bleaching assessment period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-9py9sc7	Effect of virtual reality and walking assistance in gait rehabilitation in Parkinson&apos;s patients	Not yet recruiting	Intervention	2026-04-20	<NULL>	<NULL>	9121	Impact of virtual reality and and partial body weight support  on gait rehabilitation in patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	The inclusion criteria will include participants of both sexes, with functional walking deficits; but who are able to walk without an assistive device for at least 10 meters;  weigh more than 30 kg; are able to respond to and understand commands; are in stages 1–3 of the Hoehn &amp; Yahr scale; have medical supervision; and are available for the duration required by the study	Exclusion criteria will include patients with significant cognitive impairment; severe motor impairments such as disabling dyskinesias; extreme rigidity; or severe postural instability; as well as those who require the continuous use of walking aids. In addition, individuals with acute systemic or neurological comorbidities; severe joint deformities; uncontrolled epilepsy; sensitivity to visual stimulation, or uncorrected visual and vestibular impairments that hinder the safe execution of the protocol will not be included	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-3zkf2yc	Effect of virtual reality associated with transcranial direct current stimulation to treat trunk control and improve autonomic response in people with spinal cord injury	Recruiting	Intervention	2021-05-14	<NULL>	<NULL>	4655	Effect of combined therapy of virtual reality and stimulation transcranial direct current stimulation (tDCS) in the balance of trunk and autonomic modulation in people with spinal cord injury	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2021-01-11	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3zkf2yc	<NULL>	All participants who agree to participate after reading and signing the Free and Informed Consent Term (FICT) will be included; with diagnosis of spinal cord injury - quadriplegic or paraplegic with neurological level equal to or greater than T6; age equal to or greater than 18 years and less than or equal to 60 years and with incomplete injuries.	Individuals who are not able to perform virtual reality tasks will be excluded; patients with severe heart disease; with metallic implants in the skull; deformities and / or absence of the skullcap; congenital anomalies; patients using drugs that interfere with the ANS (such as antiarrhythmics, insulin, beta-blockers); patients with associated brain injuries that have resulted in significant motor and cognitive deficits and individuals with a convulsive history.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:31
RBR-7hmq4rp	Effect of Virtual Reality in the context of medical teaching in cardiology	Recruitment completed	Intervention	2024-01-18	<NULL>	<NULL>	6738	Effect of Virtual Reality on self-confidence, motivation and acquisition of clinical skills in medical students in the context of teaching topics in cardiology	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-26	Escola Multicampi de Ciências Médicas da Universidade Federal do Rio Grande do Norte	Escola Multicampi de Ciências Médicas da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7hmq4rp	<NULL>	Undergraduate medical students at the Escola Multicampi de Ciências Médicas (EMCM) regularly enrolled in the ‘Dyspnea, Chest Pain and Edema’ module; have at least 75% attendance during the training offered; students who complete all research instruments; of both genders	Students whose data collection instruments contain partial or illegible informatio; scientific initiation scholarship holders linked to the researcher; and collaborators who contributed to the execution of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-6rrbtsd	Effect of Virtual Reality in the treatment of Chronic Neck Pain	Recruiting	Intervention	2022-11-10	<NULL>	<NULL>	5717	Virtual Reality in the management of Chronic Neck Pain: a pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade Regional de Blumenau	Universidade Regional de Blumenau	https://ensaiosclinicos.gov.br/rg/RBR-6rrbtsd	<NULL>	History of persistent pain in the cervical region, delimited posteriorly by the superior nuchal line to the spine of the scapula and laterally to the superior border of the clavicle and the sternal notch, presenting or non-irradiation to the head, trunk and upper limbs, for at least three months; score of 3 or more points on the Numerical Pain Scale (END) during movement; Cervical Disability Index (NDI) equal to or greater than 20%, that is, 10 points.	History of previous rheumatic diseases, infectious or inflammatory diseases, tumors, cervical myelopathy, vertebrobasilar insufficiency and central or peripheral neurological disorders; history of trauma, fracture, or major surgery in the cervical, thoracic, or upper limbs; signs of nerve root compression such as decreased sensitivity of upper limb dermatomes, significant muscle weakness in upper limbs, decrease, abolition or increase in biceps and triceps reflexes; pregnancy; visual deficit without adequate correction; history of motion sickness, nausea, dizziness, vertigo and/or syncope without and with the use of the virtual reality device.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-6bygmz9	Effect of Virtual Reality on Abdominal Contraction of sedentary young adults: randomized clinical trial	Not yet recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5259	Effect of Virtual Reality on Central Stabilization of sedentary young adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-18	Centro de Estudos Superiores de Maceió - CESMAC	Centro de Estudos Superiores de Maceió - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-6bygmz9	<NULL>	Age between 18 and 29 years old; male and female individuals; sedentary academics; academics with preserved mental faculties.	Non-prosthetic amputees; academics with vestibular diseases in acute crises; academics with diseases with neuromotor impairment; academics with uncontrolled cardiovascular diseases; academics who practiced physical activities for at least four months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-10v7xxmp	Effect of Visceral Osteopathy on heart rate and pain in patients with Fibromyalgia	Not yet recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5868	Effect of Visceral Osteopathic Manipulative Therapy on heart rate variability and conditional pain modulation in patients with Fibromyalgia - controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Escola de Osteopatia de Madrid	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-10v7xxmp	<NULL>	Female participants;aged between 18 and 65 years; clinical diagnosis of fibromyalgia; persistent or recurrent musculoskeletal pain greater than 12 weeks; symptomatic at the time; motor independence; good understanding of the Portuguese language to answer the questionnaires	Hstory of recent trauma or fractures; tumors or a history of cancer; rheumatologic disease in an acute inflammatory phase; heart disease; use of a pacemaker; pregnant or postpartum women who are breastfeeding during the evaluation or treatment period; cognitive limitations to complete the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-44rxxt	Effect of visceral physiotherapy in patients with low back pain	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4176	Effect of visceral physiotherapy in patients with low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Grupo de Pesquisa em Fisioterapia Avaliativa e Terapêuticas - GPFAT	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-44rxxt	<NULL>	30 individuals with chronic low back pain; regardless of gender; aged between 18 and 50 years; participating in the Clinic	volunteers with depression; anxiety; Brain stroke; Parkinson&apos;s; Alzheimer&apos;s; in addition to menstrual changes such as metrorrhagia; they must not have a history of digestive cancer; appendicitis; peritonitis; polyps; diverticulum; intestinal occlusion and malabsorption syndrome; use of analgesic and contraceptive medication for more than six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-5t2kjj4	Effect of vitamin C on periodontal treatment of diabetes	Recruitment completed	Intervention	2026-03-16	<NULL>	<NULL>	8988	Effect of ascorbic acid supplementation on periodontal treatment of individuals with type II diabetes: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-05	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Patients with type II diabetes mellitus; patients with periodontitis stage II or III; minimum age of 30 years; at least fourteen teeth in the mouth	Individuals with diseases with alteration in the immune system; smokers; individuals who make use of dietary supplementation; individuals who need a diet with low sodium concentrations; pregnant and lactating women; individuals who have undergone periodontal treatment in the last 6 months; individuals with implants and peri-implant diseases; individuals who have undergone antimicrobial and anti-inflammatory therapy in the last 3 months; Individuals who have renal dysfunction; individuals who use anticoagulants and antiplatelet agents; individuals who changed their diabetes medication during the study period; individuals using insulin; Individuals with glycated hemoglobin above 9%; individuals with fasting blood glucose above 250mg/dl	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-65q4hg	Effect of vitamin C supplementation on children with Osteogenesis Imperfecta	Data analysis completed	Intervention	2019-09-27	<NULL>	<NULL>	3006	Evaluation of musculoskeletal pain and collagen production in patients with vitamin C supplemented osteogenesis imperfecta: pilot study of a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-14	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-65q4hg	<NULL>	Patients with OI (types I, III and IV) and without other associated diseases. Age range from zero to 18 years. Patients who underwent intravenous disodium pamidronate treatment cycles at the HIJG every 2, 3, 4, or 6 months between January and December 2018. Patients who had conditions for oral medication administration. Patients who do not use continuous analgesics, continuous anti-inflammatory drugs or antidepressants for pain control or other medical indication.	PParticipants who did not attend the hospital for disodium pamidronate administration. Participants who presented temporary or permanent suspension of disodium pamidronate administration during the data collection period. Participants who did not have blood samples collected during the first or second data collection. Participants who did not return for the second data collection. Participants who used continuous analgesics, continuous anti-inflammatory drugs and antidepressants for pain control or other medical indication after the first data collection. Participants reporting inadequate vitamin C supplementation between data collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-4cj8njk	Effect of vitamin C use in third molar surgery	Recruitment completed	Intervention	2025-02-26	<NULL>	<NULL>	7797	Effect of vitamin C use on healing and postoperative symptomatology in mandibular third molar surgery	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2022-04-02	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4cj8njk	<NULL>	Healthy volunteers who do not continually use medications; both sexes; who are between 18 and 30 years old; that have teeth 38 and 48 in the same position; with indication for removal in an outpatient procedure under local anesthesia	Volunteers who do not agree to participate in the research after reading the Free and Informed Consent Form;  presence of pathological lesions such as cysts and/or tumors in the region surrounding or associated with the lower third molars; have any suspected or diagnosed allergy to any of the drugs used in the research; volunteers who did not return for the second surgical procedure, to be performed on the opposite side of the initial surgery; pregnant patients; volunteerswho have vitamin C deficiency and require regular vitamin supplementation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-3j787t	Effect of vitamin D supplementation and resistance training on muscle, bone, and inflammatory parameters in maintenance hemodialysis patients	Recruitment completed	Intervention	2018-08-07	<NULL>	<NULL>	2753	Effect of vitamin D supplementation and resistance training on body composition, physical capacity, inflammatory parameters and bone mineral metabolism in maintenance hemodialysis patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Associação Prudentina de Educação e Cultura APEC	Faculdade de Ciências e Tecnologia UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3j787t	<NULL>	Individuals older than 18 years; with chronic kidney disease on hemodialysis for a period greater than or equal to three months in the Hospital of Presidente Prudente “Doutor Domingos Leonardo Cerávolo”, Presidente Prudente, São Paulo, Brazil; do not have contraindications to physical activity; and accept and sign the Informed Consent.	Individuals unable to understand the procedures performed; prior diagnosis of coronary artery disease; positive exercise test for cardiac ischemia; Patients who have suffered stroke; patients with cancer, liver failure, chronic infection or acute in activity;  uncontrolled hypertension (&gt; 160 mmHg systolic or &gt; 100 mmHg diastolic); with amputated limbs; those that received cholecalciferol supplementation in the last 6 months; use of medications that affect body composition, such as corticosteroids and antiretroviral therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-5h432f	Effect of vitamin D3 supplementation on viral load and recovery of TCD4 + cells in HIV patients on antiretroviral therapy assisted by SUS	Recruitment completed	Intervention	2020-09-17	<NULL>	<NULL>	4251	Effect of vitamin D3 supplementation on viral load and recovery of TCD4 + cells in HIV patients on antiretroviral therapy assisted by SUS	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal do Piaui	FUNDAÇÃO DE AMPARO A PESQUISA DO PIAUÍ- FAPEPI	https://ensaiosclinicos.gov.br/rg/RBR-5h432f	<NULL>	being under treatment in Teresina; being aged 20 years; never having used ART; who are not using vitamin or mineral supplementation; who do not have a diagnosis of metabolic diseases,  diabetes, metabolic syndrome, thyroid disorders, bone diseases being treated, chronic renal failure, liver disease, gastric diseases or disabsorptive syndromes, neoplasms; pregnant and lactating women.	not complying with the proposed antiretroviral regimen or the placebo, supplement intake regimen during the six-month follow-up; pregnancy during follow-up; diagnosis of metabolic diseases, bone diseases being treated, chronic renal failure, liver disease, gastric diseases or disabsorptive syndromes, neoplasms during follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-99h2qmf	Effect of Vitamin E in pregnant women with Severe Preeclampsia	Not yet recruiting	Intervention	2024-09-23	<NULL>	<NULL>	7369	Vitamin E Supplementation in pregnant women with Severe Preeclampsia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Departamento de Análises Clínicas e Toxicológicas	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-99h2qmf	<NULL>	Pregnant women aged ≥ 18 years, diagnosed with severe preeclampsia, defined as systolic blood pressure ≥160 mmHg and/or diastolic blood pressure ≥110 mmHg or the presence of other clinical and laboratory alterations, such as: severe headache, chest pain, dyspnea, O2 saturation &lt;97%, leukocytosis, thrombocytopenia, elevated creatinine and uric acid, nausea, vomiting, epigastric pain, elevated bilirubin, plasma albumin, low non-reactive cardiotocography, oligohydramnios, umbilical artery Doppler with absent or reversed dialysis flow, will be included. The inclusion criteria also include pregnant women with inadequate levels of serum alpha tocopherol (≤ 30 mmol), from the 20th gestational week, with a single fetus and followed up at the high-risk multidisciplinary prenatal outpatient clinic at the Januário Cicco Maternity Hospital	Women with a previous or current diagnosis of Diabetes Mellitus or Gestational Diabetes Mellitus, cases of multiple pregnancies, pregnant women who smoke, have allergies or are taking supplements containing vitamin E above 50 IU, who are using illicit drugs or alcohol during the current pregnancy, have fetal abnormalities, have documented uterine bleeding within one week of screening, have pregnancies resulting from in vitro fertilization, have thrombophilia, are carriers of Human Immunodeficiency Virus, syphilis and systemic lupus erythematosus will be excluded from this study. Women with serum tocopherol levels &gt; 30 mmol/L and whose delivery does not take place at the Januário Cicco Maternity Hospital will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-76r3t7	Effect of Vocal Therapy associated with Electrical Stimulation in women with Voice Changes	Data analysis completed	Intervention	2020-08-03	<NULL>	<NULL>	4078	Effect of Electrostimulation associated with Semi-occluded Vocal Tract Exercises in patients with Behavioral Dysphonia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-76r3t7	<NULL>	Women; aged 18 to 60; behavioral dysphonia	Patients with organic changes of congenital origin; diagnosis of head and neck cancer; history of previous surgery in the head and neck region with impact on the voice; patients with neurological diseases; history of speech therapy in the last six months; history of electrical stimulation in the last six months; thyroid changes; severe heart disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-97kdbr	Effect of walk back training on the treadmill in locomotion of elderly with osteoarthritis of knee	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	46	Effect of gait training back on the treadmill in locomotor function of older adults with osteoarthritis of knee	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-30	Universidade do Estado de Santa Catarina	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-97kdbr	<NULL>	Older adults diagnosed with osteoarthritis, male and female, older than 60 years, presence of pain and stiffness of the knee to at least six months for activities in the standing position, joint pain during passive motion, intermittent swelling, radiographic joint degeneration, and who possess a medical certificate allowing physical activity.	Will be excluded individuals who present systemic rheumatic disease, previous surgery of the lower limbs, making use of orthoses for walking, any other condition that would limit or disable the implementation of proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-5p28n4	Effect of Walking and Intensive Exercise on the Health of healthy individuals	Not yet recruiting	Intervention	2017-06-19	<NULL>	<NULL>	1259	Isolated and combined effects of a Physical Exercise Session and Active Behavior on Cardiometabolic Aspects in healthy individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5p28n4	<NULL>	Volunteers with body fat percentage above 25% and 35%, for men and women, respectively; Age between 18 and 35 years; Insufficiently physically active; non smokers.	Voluntary with arterial hypertension; diabetes; In use of medication that influences the cardiovascular system; With bone or muscle limitation for walking or running.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-7qts75k	Effect of Water Exercise on blood pressure in postmenopausal women with High Blood Pressure	Recruiting	Intervention	2023-04-12	<NULL>	<NULL>	5995	Effect of Aquatic Exercise on acute blood pressure response in Hypertensive postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-21	Faculdade de Educação Física e Fisiotrapia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7qts75k	<NULL>	Women aged between 45 and 65 years; postmenopausal women (1 year of permanent amenorrhea); hypertensive patients properly medicated, not practicing physical exercises regularly and systematically for at least three months; not having musculoskeletal problems or cardiovascular complications that prevent physical exercise; present a medical certificate proving that you are fit for physical exercise; no history of stroke or acute myocardial infarction; not to smoke; not having a diagnosis of Diabetes Mellitus; not practice physical exercises during the evaluation period; not have a pacemaker.	Having any cardiovascular complications during collections; not attending all tests and sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-5x3tfq3	Effect of Water Exercise on the heart of postmenopausal women with high blood pressure	Not yet recruiting	Intervention	2025-06-19	<NULL>	<NULL>	8062	Cardiovascular effects of Aquatic Training in hypertensive postmenopausal women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-09	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Programa de Pós-Graduação em Ciências da Saúde da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5x3tfq3	<NULL>	Women; aged between 45 and 65 years; post-menopausal (1 year of permanent amenorrhea); who do not undergo hormone therapy; at most 6 years after menopause; hypertensive patients on medication; who have not practiced physical exercise regularly for at least three months, according to the response to physical activity practice obtained in the anamnesis; without musculoskeletal problems or cardiovascular complications that prevent the performance of physical exercise; must present a medical certificate proving that they are fit to practice physical exercise; have no history of stroke or acute myocardial infarction; are non-smokers and do not have a diagnosis of Diabetes Mellitus	Present any cardiovascular complications during collections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-79pss6w	Effect of Water with Ozone in the treatment of Pericoronitis	Not yet recruiting	Intervention	2024-11-22	<NULL>	<NULL>	7532	Effect of Ozonated Water as an adjunct in the treatment of Pericoronitis: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal dos Vales do Jequitinhonha e MucurI	Universidade Federal dos Vales do Jequitinhonha e MucurI	https://ensaiosclinicos.gov.br/rg/RBR-79pss6w	<NULL>	Participants with signs/symptoms of pericoronaritis, such as the occurrence of spontaneous pain, erythema, purulent or draining edema, affecting the gingiva of the oral cavity, located over the lower third molar; age 18 to 35 years; both sexes; surgical risk level I and level II, according to the American Society of Anesthesiologists (ASA I and ASA II); periodontal status level I and II, according to the American Academy of Periodontology; consent to participate in this clinical trial by signing the Informed Consent Form (ICF)	Participants with surgical risk level III and level IV, according to the American Society of Anesthesiologists (ASA III and ASA IV); with periodontal status level IV, according to the American Academy of Periodontology; undergoing antibiotic therapy in the last two months; with any medical contraindication for periodontal probing; currently using tobacco and aged less than 18 years and more than 35 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-6czzb2f	Effect of Weight training combined with Laser blanket therapy on Physical Performance and overall Well-being in elderly women	Recruiting	Intervention	2026-03-05	<NULL>	<NULL>	8944	Effect of Strength training combined with Low-intensity Laser therapy on Functional Capacity, Quality of Life, and Physical Fitness in elderly women	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-02	Universidade Católica De Brasília	<NULL>	<NULL>	<NULL>	Thirty women aged 60 or older who have been sedentary for at least three months will be selected	Women who participate in less than 80 percent of the training sessions will be excluded, resulting in the loss of the sample; Participation in another strength training program; Use of hormone replacement therapy; Inability to understand instructions due to uncontrolled hypertension, including non-adherence to treatment, undertreatment, inadequate medication, unavailability of medication in the primary health care network, quantity and number of daily doses inconsistent with prescribed medication, resistance to treatment, and presence of comorbidities; Reports of chest pain, dizziness, or malaise; Osteomyoarticular problems or any other pre-existing condition that prevents participation in the physical exercise program; Inability to understand instructions due to cognitive problems	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-5dn5zd	Effect of weight training, walking and combination of weight training with walking on blood pressure, heart rate and arterial function in patients with stroke sequelae.	Recruiting	Intervention	2020-07-28	<NULL>	<NULL>	4061	Acute effects of resistance, aerobic and concurrent exercises on blood pressure, cardiac autonomic control and arterial function in stroke survivors patients.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO	UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO	https://ensaiosclinicos.gov.br/rg/RBR-5dn5zd	<NULL>	Right or left hemiparesis, with at least six months of the occurrence of stroke; be able to walk without supervision for home walking; enrolled in a neuro-motor rehabilitation program; score above 36 on the Berg balance scale; minimum score of 50 on the Fulg-Meyer scales; signature of the written informed consent form.	"Smoking; history of drug or alcohol abuse; using beta-blockers, neuroleptics or medications that alter the threshold excitement of the neuronal membrane; hormone replacement therapy; head trauma; metallic prosthetic device in the skull; evidence of secondary hypertension; diagnosed with metabolic, liver, cardiac, oncological, psychiatric, neurological pathologies; body mass index &lt;25 or&gt; 35 kg / m2.
g) Estimated glomerular filtration rate &lt;60 mL/min;
h) Acute or chronic hepatic disease with transaminases &gt;3x upper reference value;
i) Patients with clinical evidence of coronary disease with a history of angina or tests
compatible with myocardial ischemia;
j) Previous history of acute myocardial infarction and/or myocardial
revascularization;
k) Clinical signs of heart failure, symptomatic cardiac arrhythmia or clinically
significant valve disease;
l) Patients with a history of drug or alcohol abuse in the last 10 years;
m) Patients with a history of cancer in the last five years;
n) History of neurological or psychiatric disease (e.g. epilepsy);
o) History of cranial trauma at any age or existence of a metal prosthetic device or
other metal particle in the skull."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-9w7vxd	Effect of wheelchair basketball for people with disabilities on thermogenesis	Recruiting	Intervention	2018-03-02	<NULL>	<NULL>	1671	Wheelchair basketball for people with disabilities in Mato Grosso: thermogenesis, health, sports, accessibility and quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-09	Hospital Universitário Júlio Müller da Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso-UFMT	https://ensaiosclinicos.gov.br/rg/RBR-9w7vxd	<NULL>	"voluntary gender male of the 18-60 years old, non smokers, with good capacity of upper limbs is preserved. Good intellectual understanding
Sign the informed consent form (SICF).
With medical certificate for sports practice assessing their clinical state of health for the sport of the research."	People with disabilities without sporting ability or affinities with sport. Time less than 18 months of injury. With lesions above C7, severe one cruve or two curve scolios with greater Cobbi angles 35 graus. with unstable osteometallic fixation. Weight within the variation limit of 15% of the weight considered normal for men and women, taking into account height and physical structure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-8yvd85y	Effect of Whey Protein Supplementation for Mucositis in BMT Patients	Recruitment completed	Intervention	2025-04-07	<NULL>	<NULL>	7897	Effect of Food Supplementation with Enriched Milk Protein Concentrate with TGF-ß in reducing oral Mucositis in patients undergoing BMT	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8yvd85y	<NULL>	Age over 12 years old; both genders; patients who have not started the conditioning phase	Patients who are allergic to milk proteins; lactose intolerants; suspension of oral nutrition during treatment; death occurring during the data collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-67gq57	Effect of Xbox Games on the Health of children and adolescents with Down&apos;s Syndrome	Not yet recruiting	Intervention	2019-01-24	<NULL>	<NULL>	4482	Influence of Exergames in the Anthropometric, Biochemical, Metabolic and Psychomotor Profile of individuals with Down Syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-67gq57	<NULL>	Individuals with a Down Syndrome diagnosis; studing in health and education institutions in the region of Oeste Paulista; aged between 8 and 18 years; both sexes.	Children under 8 years; adolescents over 18 years of age; use of drugs that influence cardiac autonomic activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-5r2msv	Effect of Xbox Games on the Health of Children and Adolescents with Myelomeningocele	Recruiting	Intervention	2019-12-26	<NULL>	<NULL>	4483	Influence of Exergames on the Anthropometric, Biochemical, Metabolic, Psychomotor and Quality of Life Profile in Individuals with Myelomeningocele	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5r2msv	<NULL>	Individuals with a Myelomeningocele diagnosis; studing in health and education institutions in the region of Oeste Paulista; aged between 4 and 18 years.	Individuals with previously diagnosed metabolic, biochemical, cardiovascular changes; do not understand the proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-9d29wpj	Effect of yerba mate extract consumption on anthropometric parameters, body composition, and blood markers of inflammation, glycemic profile, and lipid profile in overweight individuals	Not yet recruiting	Intervention	2025-02-14	<NULL>	<NULL>	7748	Yerba mate extract (Ilex paraguarensis): effect of ingestion on anthropometric parameters, body composition, inflammatory markers, glycemic profile, and lipid profile in overweight individuals: a randomized, placebo-controlled, crossover, and triple-blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-9d29wpj	<NULL>	Individuals over the age of 18; Body Mass Index (BMI) greater than or equal to 24.99 kg/m²; both sexes	Individuals with a Body Mass Index (BMI) greater than or equal to 24.99 kg/m²; significant weight variation (more than 10%) in the last 3 months; use of anti-inflammatory medications; pregnancy or breastfeeding; allergies or hypersensitivity to any of the ingredients of the interventions; smoking; alcoholism; intense physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-5yrjrr4	Effect of zinc supplementation in patients with ulcerative colitis	Data analysis completed	Intervention	2021-09-17	<NULL>	<NULL>	4898	Effect of zinc supplementation on inflammatory markers in ulcerative colitis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	REGINA MÁRCIA SOARES CAVALCANTE	UNIVERSIDADE FEDERAL DO PIAUÍ	https://ensaiosclinicos.gov.br/rg/RBR-5yrjrr4	<NULL>	Patients diagnosed with ulcerative colitis (with at least 6 months of diagnosis time);non-smokers; without coexisting pathologies such as diabetes; hypertension and kidney disease;cardiovascular diseases; rheumatic diseases and any other diseases involving an inflammatory process; without the use of a vitamin-mineral supplement;  who voluntarily agreed to participate in the research, with the consent materialized by signing the Informed Consent Term.	Patients who changed city and/or state; who did not have telephone contact;who discontinued use of the supplement; who did not attend the collection of biological material	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-4q8rgp	Effect to use occlusal bite on the progression of dental abrasion	Data analysis completed	Intervention	2019-11-18	<NULL>	<NULL>	3197	Effect of occlusal plaque on the progression of abfration lesions	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4q8rgp	<NULL>	Two visually perceptible lesions on the buccal surface of the teeth; visually perceptible and without indication of restoration; with or without TMD and / or the presence of excessive occlusal wear due to teeth clenching and / or grinding.	Non-carious cervical lesions in patients with GERD; using continuous medication that could interfere with salivary flow and promote dental erosion; those diagnosed with less than 2 abfraction lesions; very extensive lesions and teeth with gyroversion; or without antagonist and adjacent teeth and with idiopathic erosion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-7g4gp4	Effect, safety and action of Ketotifen associated with Famotidine  in the treatment of facial stains.	Not yet recruiting	Intervention	2020-03-20	<NULL>	<NULL>	3637	Evaluation of the efficacy of using Ketotifen associated with Famotidine in the oral treatment of facial melasma in women: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-20	Faculdade de Medicina de Botucatu (FMB - Unesp)	Faculdade de Medicina de Botucatu (FMB Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-7g4gp4	<NULL>	women; aged 18 to 60 years; moderate to severe facial melasma; no treatment for at least 30 days.	dermatoses with photosensitivity; history of hypersensitivity to ketotifen or famotidine; personal history of liver disease; pregnant women; lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-56p5mj	Effectiveness analysis of very small-bore catheters for drainage of malignant pleural effusions	Recruiting	Intervention	2016-01-28	<NULL>	<NULL>	698	Effectiveness analysis of very small-bore catheters for drainage of malignant pleural effusions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-16	Centro Universitário da Faculdade de Saúde, Ciências Humanas e Tecnológicas do Piauí	Nabor Bezerra de Moura Júnior	https://ensaiosclinicos.gov.br/rg/RBR-56p5mj	<NULL>	"Patients with malignant pleural effusion requiring chest drainage
Agreement  with the research and signing of the Informed Consent Form."	"Patients less than 18 years-old
Empyema
Post-operative period of thoracic surgery
Patients using sedatives and / or mechanical ventilation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-10tkjh3t	Effectiveness and durability of ready-to-use botulinum toxin A formulations (Relfydess and Alluzience) for treating moderate to severe frown lines: a randomized controlled clinical trial	Recruitment completed	Intervention	2026-04-26	<NULL>	<NULL>	9139	Efficacy and durability of liquid formulations of botulinum toxin type A, Relabotulinumtoxin-A (Relfydess) and RTU Abobotulinumtoxin-A (Alluzience), in the treatment of moderate-to-severe dynamic glabellar lines: a randomized, controlled, triple-blind clinical study	<NULL>	3, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Centro Universitário Uningá	<NULL>	<NULL>	<NULL>	"female patients aged between 25 and 50 years; presence of dynamic glabellar lines involving the procerus and corrugator muscles; no botulinum toxin injections within the last year for aesthetic or therapeutic purposes in any body region; moderate to severe glabellar lines according to the 5-point Merz scale; and no aesthetic procedures performed in the upper third of the face within the last year.
3. Moderate to severe glabellar lines according to the 5-point Merz scale;
4. No other aesthetic procedures performed in the upper third of the face within the last year."	receipt of tetanus or COVID-19 vaccination within the last three months prior to study initiation; presence of autoimmune diseases; pregnancy or breastfeeding; presence of neuromuscular disorders, such as myasthenia gravis or Lambert–Eaton syndrome; current use of medications affecting neuromuscular junctions; engagement in high-intensity physical exercise; and refusal or inability to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-2qybt6	Effectiveness and Genetic Damage associated with Tooth Whitening	Recruitment completed	Intervention	2018-07-27	<NULL>	<NULL>	2065	Effectiveness of Bleaching with 37%  Carbamide Peroxide With and Without Sonic Activation and Genotoxic Effect: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Universidade Federal do Amazonas - UFAM	Universidade Federal do Amazonas - UFAM	https://ensaiosclinicos.gov.br/rg/RBR-2qybt6	<NULL>	Patient from 18 years of age; upper teeth free of caries; anterior superior teeth free of restorations on the vestibular face; central or canine incisors showing coloration C2 or darker	Pregnant or lactating; Smokers; Users of fixed orthodontic appliance; Individuals with severe intrinsic stains on the teeth; Users of drugs with anti-inflammatory and antioxidant action; Participants with a previous history of dental sensitivity or any associated pathology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-1034tqgd	Effectiveness and safety evaluate of Covid-19 vaccines by the National Immunization Program: a multicenter cohort study in brazilian healthcare workers	Recruitment completed	Observational	2025-06-24	<NULL>	<NULL>	8064	Effectiveness and safety of Covid-19 vaccines by the National Immunization Program: a multicenter cohort study in healthcare workers	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-27	Empresa Brasileira de Serviços Hospitalares	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-1034tqgd	<NULL>	Healthcare workers; over the age of 18; both sexes; working in the public and/or private healthcare system in of Brazil	Individuals who had been vaccinated for COVID-19 in a clinical trial taking place in parallel at the research sites	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-2q5yjx	Effectiveness and safety evaluation of biomembrane hemicellulose versus curative collagenase in the treatment of chronic venous ulcers	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1007	Biomembranse of hemicellulose dressing versus collagenase in the treatment of chronic venous ulcers: randomized clinical trial, open and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-08	Faculdade de Medicina de Botucatu - Unesp	Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-2q5yjx	<NULL>	"Sign the consent form; ge above 18 years; of both sexes; Venous chronic disease with venous chronic ulcer evidenced by one or more of the following signs: Hyperpigmentation of the distal third of the lower limb; stasis eczema; lipodermatosclerosis; varicose veins; One or more ulcers whose minimum evolution time is 6 weeks; present ulcer whose largest size is linear up to 20cm; Ulcers do not occur throughout the circumference of the member
Do not use venotonics drugs; pentoxifylline and fibrinolytic drugs in the last two weeks before the study"	"Having other etiologies ulcers (peripheral arterial disease, causes hematologic, neoplastic, infectious, etc.); Ulcer whose largest linear size is more than 20cm; Ulcers occurring throughout the limb circumference;
Infected ulcer, or when combined with erysipelas, cellulitis or lymphangitis;
Ulcers with critical colonization, or large amounts of exudate and/or foul odor and/or color of the green bed; Necrosis presence in ulcer bed; Venous ulcers associated with peripheral arterial disease that is characterized when the ankle-brachial systolic index (ABI) is less than 0.9 and / or absence of distal pulses, mainly tibioso; History of hypersensitivity to the proposed treatments"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-3dbmqs	Effectiveness and safety of a new cryotherapy vest to reduce core temperature in athletes (healthy volunteers) after aerobic activity	Not yet recruiting	Intervention	2020-02-03	<NULL>	<NULL>	3446	Effectiveness and safety of a new cryotherapy vest to reduce core temperature in athletes (healthy volunteers) after aerobic activity: Crossover Randomized Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Centro Universitário São Camilo	Centro Universitário São Camilo	https://ensaiosclinicos.gov.br/rg/RBR-3dbmqs	<NULL>	Participants of either sex aged greater than 18 years but less than 60 years; Professional or semi-professional athletes practicing physical activity at least 2x / week for more than 6 months; Signed informed consent; Completion of modified physical activity readiness (Par-Q) and global physical activity fitness (GPAQ) questionnaires; Able to use a treadmill.	Present with signs or symptoms of acute or chronic illness; Athletes with an initial core temperature less than 35.5 or greater than 37.5 °C; BMI greater than 30 kg/m2; Skin lesions evident or reported by athletes or medical staff that contraindicate participation in the study, such as purulent skin gangrene; Known joint and/or muscle injuries that contraindicate the use of a treadmill; Have contraindications to cryotherapy such as cryoglobulinemia, cold intolerance, Raynaud&apos;s disease, hypothyroidism, acute respiratory system disorder, cardiovascular disease (unstable angina or CHF class III and IV), sympathetic nervous system neuropathy, local blood flow disorders, and cachexia; Current participation in another ongoing clinical trial.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8cq89mp	Effectiveness and safety of at-home tooth Whitening: a clinical study	Not yet recruiting	Intervention	2025-09-29	<NULL>	<NULL>	8323	Efficacy and safety of DSP Home Tooth Whitening: A prospective, single-Blind, randomized study	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-09-30	Universidade Estadual de Ponta Grossa	Programa de Pós Graduação em Odontologia da Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8cq89mp	<NULL>	Patients of both sexes; aged 18 years or older; in good general and oral health; absence of carious lesions, restorations, and endodontic treatment in at least the six maxillary anterior teeth; right and left maxillary canines with shade A2 or darker, assessed by comparison with a value-oriented shade guide	Patients with dental prostheses; orthodontic appliances; pregnant or breastfeeding women; smokers; participants with a history of tooth whitening procedures; individuals with bruxism; gingival recession; dentin exposure; visible cracks in the teeth; history of dentin hypersensitivity; users of anti-inflammatory medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-8y3sj9	Effectiveness and safety of colchicin crema 0,5% versus photodynamic therapy  in treating areas with precancerous lesions	Recruiting	Intervention	2016-06-16	<NULL>	<NULL>	893	Effectiveness and safety colchicine cream 0,5% versus photodynamic therapy wuith mehtyl aminolevulinate in treatment of skin field cancerization: a randomized clinical trialE	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Faculdade de Medicina - Unesp Botucatu	Faculdade de Medicina - Unesp Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8y3sj9	<NULL>	Sign the Statement of Consent. Age above 18 years of both sexes. Provide at least three and no more than ten clinically compatible with actinic keratosis lesions on each forearm.	"Lesions in fewer than three or greater than ten in each forearm.
Selected treatment area that has atypical clinical appearance or other extensive dermatoses forearms . 
Current and previous clinical diagnosis or evidence of other diseases .
Display hypersensitivity or allergy to any of subustâncias study . 
Patients using any topical or systemic immunosuppressive substance .
Use of other skin treatment.
Immunocompromised individuals .
Coagulation disorders .
Pregnancy suspected or confirmed.
Women of childbearing potential not using contraception.
Women breast-feeding ."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-6tmdrtg	Effectiveness and safety of the Butantan-DV single-dose tetravalent vaccine against Dengue: real-world data after mass vaccination in the municipality of Botucatu	Recruiting	Observational	2026-02-23	<NULL>	<NULL>	8917	Mass vaccination for Dengue control in Botucatu: effectiveness and safety profile evaluation of the single-dose tetravalent vaccine Butantan-DV	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-19	Ministério da Saúde	<NULL>	<NULL>	<NULL>	Botucatu residents (case-control and cohort) or Polo Cuesta residents (cohort study only) aged between 15 and 59 years; Individuals with suspected dengue infection to be investigated at Emergency Rooms or Primary Health Care Units; Performance of RT-PCR for dengue for residents of Botucatu and São Manuel (for cases from other Polo Cuesta municipalities, rapid NS1 antigen testing may also be considered).	Not applicable	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-3875dd	Effectiveness and safety of yellow fever vaccination in patients with rheumatic diseases	Recruiting	Observational	2020-03-05	<NULL>	<NULL>	3565	Immunogenicity and safety of primary yellow fever vaccination in patients with rheumatic diseases	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Hospital Universitário Cassiano Antônio de Moraes	Hospital Universitário Cassiano Antônio de Moraes	https://ensaiosclinicos.gov.br/rg/RBR-3875dd	<NULL>	The present study included patients with rheumatic diseases including Rheumatoid Arthritis, Systemic Erythematosus Lupus, Sjögren Syndrome, Systemic Sclerosis and Spondylarthritis over 18 years of age  who received yellow fever 17DD anti-mammalian first vaccination in the 2017 Brazilian Campaign from January until December 2017. The control group consisted of individuals who spontaneously searched the Rheumatology Service of HUCAM to receive yellow fever first vacination YF 17DD antimammalian Biomanguinhos-FIOCRUZ in the 2017 Brazilian Campaign and who did not have immune mediated rheumatic disease and no history of previous yellow fever vaccination.	Exclusion criteria included patients under 18 years of age, patients with history of previous yellow fever vaccination, patients external to HUCAM who have not been referred by a rheumatologist by letter or direct contact of the attending physician indicating the diagnosis and medications in use, those who do not agree to participate; patients immunosuppressed by other causes such as HIV infected, CD4 count less than 200 cells per mm3, organ transplantation history, primary immunodeficiency, neoplasia, previous history of timus disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-8rtrkh	Effectiveness and sensitivity of home bleaching with hydrogen peroxide with different times of use.	Recruitment completed	Intervention	2017-06-12	<NULL>	<NULL>	1254	Effectiveness and dental sensitivity resulting from the use of 10% hydrogen peroxide in different use protocols - clinical study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-17	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8rtrkh	<NULL>	Patients will be included: 18 years of age or older, with good oral and general health, teeth free of caries lesions, teeth with color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and who agree With the informed consent form (TCLE).	Patients who have undergone dental bleaching, who have dental prostheses or restorations in the upper anterior teeth, who are pregnant or breastfeeding, have gingival retractions, dental sensitivity, endodontic treatment in the upper anterior teeth, severe dental dimming By tetracycline, fluorosis or endodontia), non-carious cervical lesions, fixed orthodontic appliance, habits of bruxism, smoking and visible cracks in the teeth and that are making continuous use of some medication, such as analgesics and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-1044sz68	Effectiveness and tolerance of Deep Peeling compared to Imiquimod cream in the treatment of Actinic Cheilitis	Not yet recruiting	Intervention	2021-04-19	<NULL>	<NULL>	4615	Effectiveness and tolerance of Phenol-Croton Peel 1,6% versus Imiquimode in the treatment of Actinic Queilites: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	UNESP - Universidade Estadual Paulista	UNESP - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-1044sz68	<NULL>	Sign the Informed Consent Form; age over 18 years of both sexes; present histological diagnosis of QA in the lower lip.	Phototypes V and VI; selected treatment area that has atypical clinical appearance or other dermatoses; current and previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; present current or previous diagnosis of CPB on the lower lip; present hypersensitivity or allergy to any of the substances under study; any treatment for QA in the last 8 weeks except photoprotection; suspected or confirmed pregnancy; women of childbearing potential who do not use contraception; women who are breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-3p7zcf	Effectiveness comparison of physiotherapy with balance and gait exercises and physical therapy with strengthening exercises in patients with Parkinson&apos;s disease	Recruitment completed	Intervention	2014-12-17	<NULL>	<NULL>	365	Effectiveness comparison of the Bobath concept versus muscle strength training to improve motor and non-motor symptoms in patients with Parkinson&apos;s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-3p7zcf	<NULL>	"Medical diagnosis of Parkinson&apos;s disease, according to the criteria of the London Brain Bank (Uk Parkinson&apos;s Disease Society Brain Bank Clinical Diagnostic Criteria): First step: Bradykinesia associated with at least one of the following symptoms: resting tremor, muscle stiffness or alteration of postular reflexes; Second stage: diagnostic exclusion criteria; Lack of clinical signs of secondary forms of parkinsonism or parkinsonism; No change in eye movements, dementia in the first year of symptoms,  cerebellar ataxia, severe dysautonomia, falls and serious imbalance in the first year of symptoms, etc. Third stage: Criteria for diagnoses support; Home unilateral and asymmetrical course;
The first side is affected the most committed throughout evolution; Presence of resting tremor; Progression of symptoms;
Excellent response to levodopa; Response to levodopa lasting five or more years; Levodopa-induced dyskinesia; Clinical course of ten years or more. Individuals over 50 years. Do not  institutionalized. Mini Mental score at least that does not characterize cognitive impairment. Hohen Yahr 1.5 to 3.0. What part of the project accept and sign the consent according term to the criteria of the Ethics Committee of the Universidade Estadual de Londrina, according to the parecer 466/2912 (CNS)."	Individuals who perform other therapeutic treatment beyond drug that has change in medication during the study or those with associated diseases, such as neurological disorders, severe heart disease, amputations, cognitive deficits or understanding. Change in the stabilization of the antiparkinsonian doses throughout the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-649bhb	Effectiveness Evaluation of a Comprehensive Care Model in Oral Health for Pregnant Women in Gestational Outcomes: Randomized Clinical Trial	Data analysis completed	Intervention	2019-03-14	<NULL>	<NULL>	2523	Validation of a Comprehensive Care Model in Oral Health for Pregnant Women and Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-19	Instituto de Medicina Integral Professor Fernando Figueira	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-649bhb	<NULL>	"Pregnant women registered in e-sus of the municipality&apos;s Basic Health Units in the study;
Have time to participate in the meetings determined during the research;Be in the first trimester of pregnancy (0 to 13 weeks) or in the first prenatal visit of the second trimester (14 to 26 weeks) during the recruitment period;Be accompanied by the Family Health team (eSF) during prenatal care at UBS."	Pregnant women with psychiatric problems;Pregnant women with HIV and / or autoimmune diseases;Pregnant women who use illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-2vxzvkz	Effectiveness in the reduction of Dentin Hypersensitivity and assessment of quality of life in patients using 8% Arginine-based toothpaste and low-intensity laser: interventional study	Recruiting	Intervention	2023-10-13	<NULL>	<NULL>	6505	Efficacy in reducing dentin hypersensitivity and assessing quality of life in patients using 8% arginine-based dentifrices and laser photobiomodulation of low intensity. Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-04	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-2vxzvkz	<NULL>	Individuals must be at least 18 years old; clear clinical presence of alterations such as abrasion, attrition and erosion in anterior and/or posterior teeth; present hypersensitivity in two non-adjacent teeth; response to air jet stimulus for one second in the cervical region, as defined by score 2 or 3 on the Schiff scale, for sensitivity to air stimulus; visible plaque index and gingival bleeding index less than 20%.	Individuals with allergies to any product to be tested; individuals with clinical presence of serious pathologies in the soft tissues; individuals undergoing chemotherapy and radiotherapy; individuals with gingivitis and/or periodontitis; subjects who started taking anticonvulsants, antihistamines, sedatives, tranquilizers, anti-depressive, anti-inflammatory or analgesic drugs within one month before the start of the study or who would start taking them during the study; subjects who took antibiotics up to three months before the study; individuals who are participating in another study; pregnant or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-9qpn2b	Effectiveness Mobilization with movement and Tape of Mulligan in ankle Functional Unstable: a randomized study	Data analysis completed	Intervention	2017-10-17	<NULL>	<NULL>	1425	Effectiveness MWM e Tape of  Mulligan in ankles Functional Unstable: a randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Salgado de Oliveira	Universidade Nacional de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-9qpn2b	<NULL>	"Informed Consent Term.
Both sexes.
Age between 18-50 years.
History of ankle sprain injury.
Score below 17 on the CAIT questionnaire.
Body mass less than 25%."	"Disabling pain in any joint of the lower limb including the ankle.
They had already undergone surgery on the lower limb.
History of lower limb fracture.
That they were allergic to the components of the different types of bandage.
Any other contraindication to physical exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-65ynybq	Effectiveness of a Behavioral Approach to Physical Activity in Adults	Not yet recruiting	Intervention	2026-03-02	<NULL>	<NULL>	8925	Effectiveness of a Behavioral Intervention in Physical Activity Practice Among Adults	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Escola de Educação Física e Esporte da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Aged between 40 and 70 years. Active staff member of the University of São Paulo with a weekly workload greater than 30 hours. Reporting less than 150 minutes per week of moderate intensity physical activity. Availability to participate in all stages of the 16 week protocol	Medical contraindications to moderate intensity physical activity identified during initial screening using the Physical Activity Readiness Questionnaire and health history assessment. Pregnancy or planned extended leave from work during the study period. Participation in another formal physical activity program involving more than 150 minutes per week of moderate intensity physical activity. Refusal to use monitoring devices including triaxial accelerometer and smartband	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-2m7qkjy	Effectiveness of a care plan for cancer survivors	Recruiting	Intervention	2022-04-19	<NULL>	<NULL>	5350	Efficacy of the Treatment Summary and Survivorship Care Plan (TSSCP-S): experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de São Paulo	Fundação Antônio Prudente	https://ensaiosclinicos.gov.br/rg/RBR-2m7qkjy	<NULL>	Age over 18; breast cancer patients; women; tumor at all stages; submitted to clinical therapies with chemotherapy, surgical and radiotherapy; who have completed the treatment (except endocrine therapy)	Patients who have not undergone surgical procedures for the treatment of breast cancer; patients with psychiatric disorders attested to in medical records, which makes educational practice unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-3tzxg2	Effectiveness of a Flowchart as an Educator for Breastfeeding Assistance in Premature Newborns	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	4661	Effectiveness of a Flowchart as a Guide for the Clinical Management of Breastfeeding in Premature Newborns	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-3tzxg2	<NULL>	Performance in the management of breastfeeding with the premature newborn; for at least six months.	Not have taken part in the first phase of the research; to be on vacation; to be on certified or absent from the service; impossibility for any reason to complete all the steps provided for in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:31
RBR-85kywk3	Effectiveness of a long-acting medicament for the treatment of gingival inflammation	Recruitment completed	Intervention	2021-10-08	<NULL>	<NULL>	4950	Effect of a chlorhexidine controlled release system for plaque control and gingivitis - randomized clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2017-01-15	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-85kywk3	<NULL>	"Patients under orthodontic treatment with clinical diagnosis of gingivitis;
Treatment with fixed appliances without dental extraction for a minimum period of six months;
Presence of allergic series on the components of the gels;
antibiotic therapy within six months."	"Preoperative periodontal treatment;
Presence of acute periodontal
smokers;
pregnant women;
Treatment with chlorhexidine 0.12% or other chemical agent;
Presence of Candidiasis;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-23h6k87	Effectiveness of a Mindful Eating for Health Program among Hospital Staff	Recruiting	Intervention	2024-03-18	<NULL>	<NULL>	6866	Effectiveness of a Mindful Eating for Health Program among Hospital Staff: a pragmatic mixed-methods randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23h6k87	<NULL>	Adults; aged 20 to 59; both genders; body mass index equal to or greater than 18.5 kg/m² and less than 40 kg/m²	Individuals undergoing pharmacological treatment for obesity; pregnancy; individuals with untreated hypothyroidism or hyperthyroidism (TSH &lt;0.2 or &gt; 5.5 mlU/mL) or treated less than 6 months ago; individuals in an acute phase of depression (less than 6 months in depression), those with schizophrenia or psychotic disorders, or those using medication that causes cognitive, attention, and concentration impairments (such as potent anxiolytics); practitioners of mindfulness, meditation, yoga, or similar practices within the last 6 months (with formal practice at least once a week); individuals who have undergone any type of bariatric surgery; extreme obesity (BMI equal to or greater than 40 kg/m²); participation in other clinical intervention studies; chronic kidney disease, heart failure, and other clinical conditions that may interfere with fluid balance; individuals who received nutritional guidance in the last 6 months; individuals being diagnosed with anorexia nervosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-8x8g36	Effectiveness of a mouthwash and toothpaste containing PHTALOX in controlling symptoms of COVID-19 and flu	Not yet recruiting	Intervention	2020-10-29	<NULL>	<NULL>	4357	Efficacy of mouthwash and toothpaste containing PHTALOX in the clinical control of COVID-19 and Flu Syndrome: a randomized triple-blind clinical tria	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2020-11-01	Instituto Federal do Paraná	Instituto Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8x8g36	<NULL>	Adult individuals (&gt; 18 years old), of both sexes, from the city of Londrina with clinical suspicion of COVID-19, submitted to testing through RT-PCR at the Sabará-Londrina Emergency Care Unit (UPA), who have no contraindications to perform mouthwash / gargle and have access to the cell phone with communication application (WhatsApp).	Patients who do not present clinical conditions, during the research, to perform mouthwashes / gargles daily, who did not tolerate the use of the products, who are hospitalized for treatment of the disease or give up participating in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-3fc62c	Effectiveness of a Neck Exercises Program  in Pain and Function of patients with mouth Articulation Dysfunction.	Recruiting	Intervention	2018-02-05	<NULL>	<NULL>	4342	Effectiveness of a cervical exercises program  in pain and functionality of patients with temporomandibular dysfunction: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3fc62c	<NULL>	Age between 18 and 45 years; Complaint of pain in the orofacial region in the last 6 months; Diagnosis of masticatory myofascial pain determined according to the criteria established by the Research Diagnostic Criteria (DC / DTM); Classification of moderate to severe orofacial dysfunction according to the Mandibular Functional Limitation Questionnaire; Complete dentition with the exception of third molars.	Patients who have a history of facial or cervical trauma, have undergone a surgical procedure in the cervical spine and / or the craniofacial segment; Neurological disorders; Fibromyalgia; Chronic systemic diseases previous treatments performed in the last six months for TMD; Use of dental prostheses and orthodontic treatment in progress.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-108f6gyv	Effectiveness of a New Placebo Acupuncture Device in Healthy Individuals: A random study	Recruitment completed	Intervention	2021-09-30	<NULL>	<NULL>	4924	Analysis Of The Effectiveness Of a New Placebo Acupuncture Device In Healthy Individuals: A random study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-108f6gyv	<NULL>	Healthy volunteers; over 18 years of age; who have never received acupuncture treatment; and who sign the free and informed consent form	Pregnant women; puerperal women; subjects with infectious processes; skin lesions in the puncture region; nervous tissue disease; inability to understand the instructions for the study; psychiatric diseases; presence of auditory; visual; communicative or cognitive disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-7vyw8p	Effectiveness of a Novel Multicomponent Treatment in patients with Fibromyalgia: Clinical study	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	5799	Effectiveness of a Novel Multicomponent Treatment versus Conventional Treatment in patients with Fibromyalgia: Randomized clinical trial, single blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	Universidad Gabriela Mistral	Universidad de las Americas	https://ensaiosclinicos.gov.br/rg/RBR-7vyw8p	<NULL>	Women subjects whose age range from 18 to 60 years derived to the rehabilitate foundation with medical diagnosis of fibromyalgia based on the criteria of the American College of Rheumatology; subjects reporting moderate pain of at least 4/10 EVA; subjects who can read, write and follow basic instructions in Spanish; subjects that accept and sign the informed consent.	Women in stages of pregnancy and / or lactation; women with chronic oncological pain; women with metabolic disorder and / or uncontrolled comorbidities and who present some psychiatric or cognitive alteration that prevents them from participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-2q2f7h	Effectiveness of a nursing intervention for the reduction of preoperative anxiety in patients scheduled for knee surgery: Randomized, preventive controlled clinical trial	Data analysis completed	Intervention	2019-06-13	<NULL>	<NULL>	2758	Effectiveness of a nursing intervention for the reduction of preoperative anxiety in patients scheduled for knee surgery: Randomized, preventive controlled clinical tria	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-10	Universidad Nacional de Colombia	Clinica de Especialistas	https://ensaiosclinicos.gov.br/rg/RBR-2q2f7h	<NULL>	"Comprised patients admitted to the 
preoperative evaluation, during the period from January to April 30 2018. Inclusion 
criteria were: persons between 50 to 75 years, patients scheduled for replacement less than 2 
months after the procedure knee"	"Exclusion criteria were: people with intellectual cognitive 
impairment, programmed to a different arthroplasty or knee replacement and denial of the 
patient to participate in research surgical procedure people."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-9rnxgfk	Effectiveness of a Physiotherapeutic Protocol of Lung and Muscle Exercises in elderly individuals who stay at home and have difficulty walking	Recruitment completed	Intervention	2023-07-05	<NULL>	<NULL>	6207	Effectiveness of a Physiotherapeutic Protocol of Cardiorespiratory and Motor Exercises in elderly individuals living with reduced mobility	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-12	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-9rnxgfk	<NULL>	Individuals aged 65 or over; of both sexes; restricted to their home; have low mobility	Individuals with a surgical procedure less than 60 days; Short Physical Performance Battery level A; not accepting to participate in the study; present cognitive alteration; perform private or public physiotherapy within the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-5m42mh	Effectiveness of a protected activation exercise program in patients with arthroscopic rotator cuff surgery	Recruiting	Intervention	2018-12-18	<NULL>	<NULL>	3258	Effectiveness of a supervised early exercise program in patients with arthroscopic rotator cuff repair: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	CDT Hospital San Borja de Arriaran	Universidad de las Americas	https://ensaiosclinicos.gov.br/rg/RBR-5m42mh	<NULL>	Subjects of both genders; whose age range is between 18 and 55 years with medical diagnosis of total rupture of the supraspinatus muscle, based on clinical and imaging criteria (ECOTOMOGRAPHY and MRI); submitted to arthroscopic repair with simple suture by the team of Traumatologists of the HCSB Arriarán; accept and sign the informed consent.	subjects with massive rotator cuff tear (2 or more tendons and / or injury greater than 5 cm) and with presence of associated lesions Example; Glenohumeral Instability; Adhesive Capsulitis; Cervical Hernia etc.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-87bg28	Effectiveness of a psychoeducation program to reduce barriers and stigmas of patients with breast cancer in relation to palliative care	Not yet recruiting	Intervention	2020-08-18	<NULL>	<NULL>	4635	Effectiveness of a psychoeducation program to reduce barriers and stigmas of patients with breast cancer in relation to palliative care	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-10	Fundação Pio XII	Barretos Cancer Hospital	https://ensaiosclinicos.gov.br/rg/RBR-87bg28	<NULL>	Women; aged between 18 and 75 years; Present a diagnosis of advanced breast cancer and have knowledge of the disease; being under palliative chemotherapy with Paclitaxel and who do not meet the criteria for immediate palliative care, in accordance with the Palliative Care Referral Protocol in force at the institution; With life expectancy greater than 6 months, at the discretion of the clinical oncologist; Be classified according to the functionality scale of the Estern Cooperative Oncology Group, with an index greater than 2 on the scale.	Being under drug treatment for mental disorders; Manifest cognitive, attention, language and orientation deficits, preventing questionnaires and instruments, according to screening criteria of the Mini Mental State Examination, considering cut-off points of 17 points for illiterates, 22 points for 1 to 4 years of age. schooling, 24 points from 5 to 8 years of schooling and 26 points for 9 or more years of schooling; Need assistance or have an appointment at the palliative care unit due to advanced cancer, in accordance with the Palliative Care Referral Protocol; Have a diagnosis of advanced cancer, with no possibility of cure and associated with any of the criteria for referral for palliative care according to PECP; Present any comorbidity that, in the opinion of the researchers, prohibits the patient from participating in the study; Weekly visits to the hospital are not available.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-2nhqjnn	Effectiveness of a Quality of Life Program in reducing stress in parents of Autistic Children	Data analysis completed	Intervention	2020-11-30	<NULL>	<NULL>	4391	Effectiveness of a Quality of Life Program in reducing stress in parents of Autistic Children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-31	Daniele Leite de Barros Carvalho	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2nhqjnn	<NULL>	Caregiver of a person diagnosed with Autism Spectrum Disorder; Aged 18 or over; no acute mental disorder.	"Not being able to attend the 8 weekly meetings;
Cognitive impairment; having participated in a Mindfulness-based program before."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-35hyxxv	Effectiveness of a remote-guided physical activity program	Data analysis completed	Intervention	2025-09-30	<NULL>	<NULL>	8331	Effectiveness of a remote-guided Physical Activity Program on the health of adolescents with Severe Obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-08	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-35hyxxv	<NULL>	Adolescents aged 12 to 17 years with obesity (BMI z-score ≥ 2 for sex and age, according to WHO standards)	Disabling orthopedic or neurological conditions; inability to engage in regular physical activity; diagnosed mental disorders limiting adherence; participation in other structured weight loss or exercise programs (except school Physical Education); or lack of access to an internet-connected device with a camera.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-6q5299j	Effectiveness of a Sensorimotor Exercise Program in the sensation of joint position, balance, muscle strength, independence to move and risk of falls in the elderly	Recruitment completed	Intervention	2023-11-18	<NULL>	<NULL>	6587	Effectiveness of a Sensorimotor Exercise Program on proprioception, balance, muscle strength, functional mobility and risk of falls in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Fernando Pessoa	Universidade Fernando Pessoa	https://ensaiosclinicos.gov.br/rg/RBR-6q5299j	<NULL>	institutionalized elderly people over 70 years of age who were undergoing regular medical monitoring; medical indication for motor physiotherapy; physical autonomy when leaving bed and who were not performing physical activity regularly; ability to make decisions	elderly people with physical independence restricted to bed; wheelchair users or those who were not physically capable of walking and hemodynamic instability; severe heart disease or uncontrolled systemic arterial hypertension verified by the doctor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-2fzkjtx	Effectiveness of a training program aimed at medical residents in oncology to help manage cancer pain in a referral hospital	Not yet recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5202	Implementation of a training program directed to oncology resident physicians to support cancer pain management in a reference hospital	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Hospital de Câncer de Barretos	Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-2fzkjtx	<NULL>	First-year residents in clinical, surgical, radiotherapy and hematology oncology	First-year residents who do not wish to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-23y7xm3	Effectiveness of a Treatment Protocol Non-invasive Brain Stimulation and Oculomotor Physiotherapy in the Eye Movement of Adults with Parkinson	Not yet recruiting	Intervention	2021-05-05	<NULL>	<NULL>	4621	Effectiveness of a Treatment Protocol with Transcranial Direct Current Stimulation and Oculomotor Physiotherapy in the Saccadic Movement of Adults with Parkinson	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-23y7xm3	<NULL>	Volunteers with Parkinson&apos;s disease. Able to walk. Normal or corrected visual acuity. Preserved cognitive ability.	Persons with Aphasia of understanding. Individuals with cataracts. Retinal detachment. Macular degeneration. Low vision. Those who do not obtain 75% attendance during the intervention. Cognitive decline.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-3mr2vm	Effectiveness of abdominal compression maneuver on neck vein distention and its influence on intra-abdominal pressure and on cardiac functioning of mechanically ventilated children	Data analysis completed	Observational	2019-10-10	<NULL>	<NULL>	3451	Effectiveness of hepatic compression maneuver on internal jugular vein distention and its influence on intra-abdominal pressure and cardiac index of mechanically ventilated children	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital das Clínicas da Universidade Estadual de Campinas	Hospital das Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3mr2vm	<NULL>	Age between 28 days and 14 years old; need for central venous catheterization due to the clinical condition that justified the hospitalization; presence of bladder catheter that allows IAP measurement; patients with clinical criteria for IAP monitoring due to the risk of abdominal hypertension caused by the disease that justified their hospitalization; patients under invasive mechanical ventilation with tidal volume between 8 and 10 ml / kg of ideal weight and mean airway pressure between 8 and 12 cmH20; hemodinamically stable patients defined as age-appropriate heart rate and blood pressure (between the 10th and 90th percentiles); patients with respiratory stability defined as age-appropriate respiratory rate and arterial O2 saturation greater than 94% as measured by pulse oximetry; availability of the researcher responsible for performing the ultrasound exam.	Previous venous thrombosis in internal jugular veins; presence of collateral venous circulation in the cervical region in patients with a history of previous internal jugular vein catheterizations; Initial intra-abdominal pressure greater than 12 mmHg; peritoneal dialysis; skin lesions in the right upper quadrant of the abdomen; skin lesions in the cervical region; continuous dobutamine infusion at doses greater than 5 mcg / kg / min, adrenaline at doses greater than 0.1 mcg / kg / min, noradrenaline at doses greater than 0.1 mcg / kg / min, or milrinone at doses greater than 0.25 mcg / kg / min; intense psychomotor agitation impairing ultrasound examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-22k94c	Effectiveness of Active Video Games in adherence to ambulatory Cardiac Rehabilitation: randomized clinical trial	Not yet recruiting	Intervention	2020-07-16	<NULL>	<NULL>	4012	Effectiveness of Exergaming in adherence to Cardiac Rehabilitation Phase II: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-11	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-22k94c	<NULL>	Heart disease patients, of both sexes, over 18 years old, with medical clearance to perform CR.	Patients who had very recent acute myocardial infarction (less than 72 h); unstable angina (less than 72 h from stabilization); severe symptomatic valvular heart disease, with surgical indication; uncontrolled arterial hypertension: SBP greater than 190 mmHg and / or DBP greater than 120 mmHg; decompensated heart failure; complex ventricular arrhythmias; suspected left or unstable or severe coronary artery injury; infective endocarditis, myocarditis, pericarditis; severe, uncorrected, symptomatic congenital heart diseases; pulmonary thromboembolism and acute thrombophlebitis; aortic dissection - type A or acute phase type B; severe symptomatic obstruction of the left ventricular outflow tract with low effort-induced output; uncontrolled diabetes mellitus; acute systemic infectious condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-53bmfx	Effectiveness of Acupuncture as treatment on Headache	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1389	Effectiveness of Acupuncture as auxiliary treatment on Chronic Headache	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-53bmfx	<NULL>	Patients between 18 and 60 years old were included in the study; female; with chronic headache using medication prescribed by the Pain Specialist; who had never undergone acupuncture treatment.	Patients with decompensated and/or severe arterial hypertension; those who were diagnosed with secondary headache and were under treatment with physical therapy or other non-drug auxiliary treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-8dmfjf	Effectiveness of Acupuncture on Pain in the emergency room	Data analysis completed	Intervention	2018-06-18	<NULL>	<NULL>	1910	Evaluation of effects of Acupuncture in Pain in the emergency room	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-02	Instituto de Assistencia Medica do Servidor Publico Estadual	Instituto de Assistencia Medica do Servidor Publico Estadual	https://ensaiosclinicos.gov.br/rg/RBR-8dmfjf	<NULL>	older than 18 year-old; neck pain; back pain; low back pain; hip pain; shoulder pain; elbow pain; wrist pain; knee pain; ankle pain; pain in the hands or feet; carpal tunnel syndrome or fibromyalgia	severe psychiatric disorders; chest pain; suspected fractures; requiring emergency care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-2h7y7q	Effectiveness of adding scapular mobilization in patients with subacromial impingement syndrome: clinical study	Recruitment completed	Intervention	2019-02-25	<NULL>	<NULL>	4645	Effectiveness of adding scapular mobilization to a specific exercise program in patients with subacromial impingement syndrome: a simple blind randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	CDT Hospital San Borja de Arriaran	Universidad de las Americas	https://ensaiosclinicos.gov.br/rg/RBR-2h7y7q	<NULL>	Inclusion: Users with a medical diagnosis of subacromial impingement syndrome, based on clinical and imaging criteria (Rx, ECHO and NRM) and with decreased scapular movement evaluated with a scapulometer  ; Users of both genders, whose age range is between 18 and 55 years; Users who accept and sign the informed consent.	Exclusion: presenting pathologies of cervical origin (radiculopathies), other pathologies of the shoulder joint complex (fracture of the proximal humerus, calcific tendonitis, adhesive capsulitis, glenohumeral instability, partial or total rupture of the rotator cuff); Patients with a history of previous surgery of the affected shoulder and infiltrated with corticosteroids in the affected shoulder in the last 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-2rfyjxx	Effectiveness of Additional Treatments for Periodontitis: Clinical Study	Recruiting	Intervention	2026-01-19	<NULL>	<NULL>	8772	Efficacy of Adjuvant Therapies in non-surgical and surgical Periodontal Treatment: a randomized, controlled, clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-05	Hospital Odontológico da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	For proposals 1 and 2, participants in the first group must be between 18 and 70 years of age; be diagnosed with periodontitis stages II to IV (moderate to severe), grade A to C; with at least two non-adjacent interproximal sites presenting a probing depth greater than or equal to five millimeters; a clinical attachment level greater than or equal to three millimeters and bleeding on probing in all four quadrants; as well as a minimum of fifteen natural teeth. Participants in the second group must present a diagnosis of uncontrolled type 2 diabetes mellitus, with glycated hemoglobin levels greater than or equal to 7%. Participants in the third group must smoke ten or more cigarettes per day for at least three years. For proposal 3, participants must present maxillary and/or mandibular molars with bilateral grade II furcation involvement, located on the buccal, mesial, or distal surfaces of the maxilla or mandible; or the presence of an intrabony defect; a probing depth greater than or equal to five millimeters and a horizontal probing depth greater than or equal to three millimeters (for furcation lesions) after non-surgical periodontal therapy; intraoral periapical radiographs showing radiolucency between the roots for grade II furcation defects and at least three millimeters of evident bone loss on periapical radiographs for intrabony defects; with no endodontic involvement or with satisfactory endodontic treatment	Medical disorders that required antibiotic prophylaxis or that could influence the response to treatment; having received periodontal treatment in the last 6 months; having used medications that affect periodontal tissues in the last 6 months; smokers or ex-smokers for less than 12 months; pregnancy; extensive prosthetic rehabilitation; undergoing orthodontic treatment; carriers of blood diseases; alcoholism and use of illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-5mwfczh	Effectiveness of an active teaching method for learning to write a nursing prescription in the primary health care context	Recruitment completed	Intervention	2024-11-29	<NULL>	<NULL>	7548	Effectiveness of an active teaching method for learning to write a nursing prescription in the primary health care context: a pilot study	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-5mwfczh	<NULL>	Included were nursing students regularly enrolled in the aforementioned curricular component; men and women aged 18 and over; who were present at the application of both the instruments and the intervention; agreeing to the research objectives by signing the Informed Consent Form (ICF)	Students under the age of 18; participants in other projects, whether extension, research, monitoring or associated actions related to the theme concurrently with this research; scholarship holders or collaborators who contributed to the development of this study were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-7wwjrq3	Effectiveness of an early intervention program by telehealth for infants at high risk of Cerebral Palsy	Not yet recruiting	Intervention	2023-05-10	<NULL>	<NULL>	6065	Effectiveness of a goal-oriented collaborative early intervention program (early together) by telehealth for infants at high risk of Cerebral Palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7wwjrq3	<NULL>	Infants born at term or preterm aged three to five months corrected age for preterm infants and three to five months of chronological age for term infants at high risk of cerebral palsy	Children with clinical instability, tracheostomy or oxygen dependents	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-3bvjjm	Effectiveness of an educational booklet for the prevention of mother-to-child transmission of the Human Immunodeficiency Virus	Data analysis completed	Intervention	2018-07-20	<NULL>	<NULL>	2036	Educational booklet for prevention of vertical Human HIV: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-16	Universidade Federal do Ceará	Departamento de Enfermagem - UFC	https://ensaiosclinicos.gov.br/rg/RBR-3bvjjm	<NULL>	Have proven HIV status, to be performing prenatal care in the chosen institutions during the study data collection period	Present a state of physical or mental health compromised in order to make data collection unfeasible, pregnant women living in the streets and incarcerated, so that the mother&apos;s accompaniment is unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7p6vsr	Effectiveness of an Educative Booklet in promoting healthy lifestyle for people with HIV/Aids	Not yet recruiting	Intervention	2019-11-11	<NULL>	<NULL>	3178	Development, validation and effectiveness of an Educative Booklet in promoting healthy lifestyle in the context of Arterial Hypertension for people with HIV/Aids	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal do Ceará	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-7p6vsr	<NULL>	People with HIV/Aids; of both genders; with age above 18 years; accompanied in the outpatient clinic of infectology of Walter Cantídio University Hospital; in use of antiretroviral drugs for at least 6 months; who are able to read and understand the booklet according to the Health Literacy Scale.	Pregnancy; mental illness and medical diagnosis in medical records; be homeless, collective shelters or deprived of their liberty in penitentiaries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-9rnkbs	Effectiveness of an equipment to reduce the dispersion of particles in emergency dental care during the Covid-19 pandemic	Recruiting	Intervention	2020-09-22	<NULL>	<NULL>	4271	Effectiveness of three prototypes of a device to reduce aerolization dispersion in emergency dental care in times of SARS-CoV-2 pandemic: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Pontifícia Universidade Católica do Rio Grande do Sul	Brigada Militar do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9rnkbs	<NULL>	Age over 18, of any sex; Need for emergency dental consultation with indication of procedures that require the use of high-speed turbines and / or ultrasound tips; Written consent to participate voluntarily in the study, upon signing the Informed Consent Form (ICF).	Age below 18 years; Need for emergency dental consultation without indicating procedures that require the use of high-speed turbines and / or ultrasound tips; Use of antibiotic medication in the last six months; Any systemic condition that requires the use of prophylactic antibiotic medication prior to dental consultation (eg, mitral valve prolapse with regurgitation); Presence of signs and symptoms compatible with acute respiratory syndrome, such as difficulty in breathing and fever (temperature&gt; 38oC).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-75v8pxk	Effectiveness of an Eye Patch for preventing Corneal Injury in intensive care unit patients: an interventional study	Not yet recruiting	Intervention	2023-09-29	<NULL>	<NULL>	6469	Effectiveness of a Polyethylene Chamber for the prevention of Corneal Injury in sedated and mechanically ventilated patients: a randomized clinical trial	<NULL>	array, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-06	Universidade Federal do Acre- UFAC	Universidade Federal do Acre- UFAC	https://ensaiosclinicos.gov.br/rg/RBR-75v8pxk	<NULL>	Adult and elderly patientssedated and on mechanical ventilation from the Intensive Care Unit	Patients hospitalized for less than 48 hours or with corneal injury on admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-6kk3bx	Effectiveness of an Internet-Based Self-Guided Program to treat Depression	Recruitment completed	Intervention	2018-09-12	<NULL>	<NULL>	6026	Effectiveness of an Internet-based Self-Guided Program to treat Depression in a sample of Brazilian users: a study protocol	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Católica de Petrópolis	University of Bern	https://ensaiosclinicos.gov.br/rg/RBR-6kk3bx	<NULL>	at least 18 years of age; who have regular access to the Internet; at the moment of the intake are diagnosed with depressive disorders following the definitions of Diagnostic and Statistical Manual 5 (DSM-5) or who at least present clinically relevant depressive symptoms and who, at the same time, score higher than the cutoff point of the clinical population in the Patient Health Questionnaire-9	other severe psychiatric symptoms that are the focus of specific clinical attention (e.g., panic disorder, severe psychotic symptoms, eating disorders, manic episodes); potential to injure themselves and/or others; individuals with severe suicidal ideation; people who do not have regular access to the Internet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-4kryg4s	Effectiveness of an Internet-Delivered Physical Exercise Program in pain and physical function of women with knee Osteoarthritis	Recruitment completed	Intervention	2023-01-12	<NULL>	<NULL>	5814	Effectiveness of an Internet-delivered Physical Exercise Program in pain and physical function of women with clinical diagnosis of knee Osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4kryg4s	<NULL>	Women aged 50 years or older; Dwelling in Diamantina; Clinical diagnosis of knee osteoarthritis (uni or bilateral); Stable clinical condition in the last three months; Mild to moderate pain in the knee(s) (score &gt; 1 and ≤ 7 on the numerical pain scale	Other health conditions that prevent the evaluation or the performance of the physical exercise program (internet-delivered), such as visual and/or hearing deficit, neurological or psychiatric diseases, pulmonary or cardiac diseases, musculoskeletal limitations; Cognitive deficit assessed through the Mini-Mental State Examination; Being in physiotherapeutic treatment for knee OA; Be performing some physical exercise program; History of recent hospitalization due to cardiovascular or cerebrovascular events; Presence of knee prosthesis; Not having access to the WhatsApp Web application	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-5yr2xjb	Effectiveness of an intervention based on Mindfulness on Stress, Burnout and quality of life of nurses: a randomized clinical trial	Not yet recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6114	Mindfulness, quality of life, perception of Stress and Burnout in nursing professionals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Escola Paulista de Enfermagem	Escola Paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-5yr2xjb	<NULL>	Workers of both genders; of any age; working in a health institution for at least 1 year; exercise the role of nurse; be available to participate in all stages of the randomized clinical trial	Being unemployed, on vacation or on sick leave during the survey period; have a medical diagnosis of psychiatric or neurological disease; use some psychotropic medication and perform some meditative practice regularly in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-9j9myd	Effectiveness of an intervention designed to provide greater well-being	Recruitment completed	Intervention	2018-05-14	<NULL>	<NULL>	1789	Positive psychology and gratitude interventions: An randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9j9myd	<NULL>	Adult volunteers; minimum age of 18; both genders; active email account	Age less than 18 years; inactive email account; failure to complete the initial scales of the study and the sociodemographic questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-5qq46rb	Effectiveness of an intervention on physical activity and eating behavior in adolescents	Not yet recruiting	Intervention	2023-07-12	<NULL>	<NULL>	6232	Effectiveness of a school-based intervention on stages of behavior change related to physical activity and diet in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-5qq46rb	<NULL>	First year high school students; regularly enrolled in the selected schools; of both genders; between 13 and 18 years of age; not having physical and/or mental limitations that would prevent their participation in the stages of the study; having parental consent through the signing of the TCLE (Free and Informed Consent Form); having agreed to and signed the TALE (Free and Informed Consent Form)	Students not enrolled in the first year of high school in the selected schools; not meeting the minimum and maximum ages established; having physical and/or mental limitations that prevent their participation in the stages of the study; not having parental consent through the signing of the TCLE (Free and Informed Consent Form); not having agreed to and signed the TALE (Free and Informed Consent Form)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-7y8rwy4	Effectiveness of an intervention on risk factors for chronic non-communicable diseases in schoolchildren: PRATIQUE Health Project	Recruitment completed	Intervention	2024-10-15	<NULL>	<NULL>	7433	PRATIQUE Health Project	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7y8rwy4	<NULL>	Adolescents of both sexes enrolled in elementary school II at public schools in the city of João Pessoa; age 10 to 15 years	Adolescents who do not answer the questionnaire correctly will be excluded; those who have any cognitive or motor or visual impairment that makes it impossible for them to answer the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-237v4b	Effectiveness of an phythetapic in prevention and treatment of skin lesions caused by radiotherapy in patients with Head and Neck Cancer	Recruiting	Intervention	2013-09-16	<NULL>	<NULL>	247	Evaluating the efectiveness of calendula in the prevention and treatment of Head and Neck Radiodermatitis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-10-03	Hospital Erasto Gaertner - HEG	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-237v4b	<NULL>	"Age above 18 years,diagnosis of cancer and head and neck radiotherapy, intact skin and continuous in the head and neck, first day of radiotherapy (if new), patients with no previous history of radiotherapy in the same field / local radiation,
Consent to participate in by signing the consent form (ICF)."	Previous reports of allergic reaction in the use of one of the research products (essential fatty acids or marigold).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-2j24fkk	Effectiveness of Arginine supplementation in aiding the treatment of Sickle Cell Anemia	Not yet recruiting	Intervention	2025-08-12	<NULL>	<NULL>	8204	Randomized double-blind placebo controlled clinical trial to study the efficacy of L-arginine: adjuvant therapeutic protocol in the treatment of Sickle Cell Anemia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2026-06-01	Secretaria da Saude do Estado do Ceara	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2j24fkk	<NULL>	Adult patients with Sickle Cell Anemia; age 18 or over; of both sexes; taking hydroxyurea (dose equal to or greater than 500mg/day)	Patients who have undergone transfusion therapy in the last three months; patients using iron chelators or antioxidant vitamins; smokers; alcoholics; pregnant women; with Diabetes mellitus; renal and/or hepatic insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-97qwcyb	Effectiveness of artificial materials in preserving bone and improving tooth retention - A comparative clinical study	Recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9077	Efficacy of biphasic synthetic calcium phosphate bone substitutes with different particle sizes in alveolar preservation for implant-supported dental restoration – A randomized, parallel-group clinical trial with a negative control	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-13	Atitus Educação	<NULL>	<NULL>	<NULL>	Individuals aged 17 or older; both gender; capable of giving informed consent by signing an Informed Consent Form; in good general health; with clinical and radiographic indications for tooth extraction and the potential for subsequent implant-supported prosthetic rehabilitation; and using an appropriate method of contraception, when applicable	Individuals with local conditions that compromise surgery or healing; coagulation disorders; advanced periodontal disease; active infection at the surgical site; hypersensitivity to the study materials; systemic diseases that affect healing; use of illicit drugs; recent participation in other clinical trials; or pregnancy or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-6wtz3c	Effectiveness of At-Home Dental Whitening with Nanovetorized Carbamide Peroxide	Recruitment completed	Intervention	2018-01-23	<NULL>	<NULL>	4565	Effectiveness of At-Home Dental Whitening with Nanovetorized Carbamide Peroxide: A Randomized Multicenter Controlled Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Estadual do Oeste do Paraná	Centro Universitário do Maranhão - UniCEUMA	https://ensaiosclinicos.gov.br/rg/RBR-6wtz3c	<NULL>	Patients with good general health will be included in this study; Age between 18-50 years of age; Good oral hygiene; Absence of caries in the anterior and inferior teeth; Absence of palatal and vestibular restorations; Upper canine with A2 or darker shading, which will be evaluated with Vita Classical scale (VITA Classical Shade, Vita Zahnfabrik, Bad Säckingen, Germany).	Patients who have undergone previous bleaching procedures will be excluded; That have restorations on the anterior superior teeth; Who have canal treatment in the anterior teeth; Pregnant and / or breastfeeding; With severe internal discoloration (tetracycline, spots, fluorosis, non-vital teeth); Parafunctional habits such as bruxism; Or any other pathology that may cause sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-3vzvbx	Effectiveness of Atraumatic Restorative Treatment (fillings) and Ultra Conservative Treatment (brushing) for Dental caries in children	Data analysis completed	Intervention	2019-03-13	<NULL>	<NULL>	2518	Effectiveness and acceptance of Atraumatic Restorative Treatment (ART) and Ultra Conservative Treatment (UCT) for Dental caries in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-11-08	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3vzvbx	<NULL>	Children from first to fourth year at elementary school; 4 to 9 years-old; presenting at least one primary molar with cavitated dentin caries.	Non cooperative children; children using fixed orthodontic appliance; teeth with any sign of pulp involvement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-6k3rqh	Effectiveness of auriculotherapy in pain of persons with cancer in chemotherapy	Recruitment completed	Intervention	2016-05-05	<NULL>	<NULL>	1120	Effectiveness of auriculotherapy in pain of persons with cancer in chemotherapy: a clinical tria.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-23	Universidade Federal de Alfenas	Clicia Valim Cortes Gradim	https://ensaiosclinicos.gov.br/rg/RBR-6k3rqh	<NULL>	Inclusion criteria will be considered: being in chemotherapy treatment and mentally oriented; Presenting pain greater than or equal to four in the Numerical Pain Scale; Be accompanied by the oncology sector (UNACON) and / or the Dor Hospital Clinic; Accept needle treatment and present age equal to or greater than 18 years.	As exclusion criteria, the presence of conditions that would contraindicate the insertion of needles at auriculotherapy sites (lesions, edema, absence of the auricular pavilion, among others) will be considered; Allergy to micropore; Terminal patient and / or with cancer of the head and neck and people who use anticoagulants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-4hzzc5w	Effectiveness of Auriculotherapy on fatigue, sleep and quality of life in nursing students: study with data collection before and after the intervention	Recruiting	Intervention	2025-09-12	<NULL>	<NULL>	8276	Effectiveness of Auriculotherapy on fatigue, quality of life, and sleep of nursing university students: quasi-experimental study	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Federal de Santa Maria	Programa de Pós-Graduação em Enfermagem da Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-4hzzc5w	<NULL>	Students from the 4th semester to the 8th semester regularly in the nursing course and who have not had total or partial suspension of the course; students who obtain scores of poor sleep quality and high fatigue; all genders and over 18 years old	Students who are partially or completely suspended from the course will be excluded from the intervention if they are undertaking other energetic therapies (Reiki, therapeutic touch, yoga, Ayurveda, among others); use of anxiolytics; antidepressants and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-2vrqrn	Effectiveness of Automatic Brushes in Down Syndrome Patients	Data analysis completed	Intervention	2017-10-04	<NULL>	<NULL>	1413	Brush effectiveness compared to manual brush without dental biofilm control with down syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-03	Universidade Federal do Piauí	Secretaria de Educação do Estado do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2vrqrn	<NULL>	Individuals with medical diagnosis of Down Syndrome; In the age group from 4 to 14 years of age; Linked to the local study center; Have in the dental arch 1 tooth or more in each sextant.	Individuals with systemic alterations or psychological condition that make participation in the study impracticable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-4wzz4xy	Effectiveness of Bach Flower Therapy in reducing stress of nursing workers	Recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4974	Effectiveness of Bach Flower Therapy in reducing Stress of nursing workers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-15	Escola de Enfermagem da Universidade de São Paulo	Secretaria Municipal de Saúde de Osasco	https://ensaiosclinicos.gov.br/rg/RBR-4wzz4xy	<NULL>	Volunteers who work in primary care nursing; have worked at the institution for at least six months; agree to use the floral formula as indicated	Volunteers diagnosed with or undergoing drug treatment for psychiatric illnesses; alcoholism self-report; being on vacation during the data collection period; use other integrative and complementary therapies during the research; have used Floral Therapy for less than six months ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-5d26k2	Effectiveness of Behavioral Interventions aimed at Self-Care in Diabetes Mellitus	Recruitment completed	Intervention	2019-10-15	<NULL>	<NULL>	3090	Evaluation of the Effectiveness of Behavioral Interventions aimed at Self-Care in Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-05	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5d26k2	<NULL>	Degree of education above the fourth grade of elementary school and the possibility of attending bimonthly three times the educational practices.	patients with diabetes with reading disability; chronic complications (defined as renal failure; blindness; limb amputation; among others).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-5kyg2r	Effectiveness of Betamethasone versus Triamcinolone injection in the treatment of Alopecia	Data analysis completed	Intervention	2020-05-25	<NULL>	<NULL>	3868	Effectiveness of intralesional Betametasone versus Triancinolone Acetonide in the treatment of Alopecia Areata	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-24	Universidade Federal do Ceará, Campus Sobral	Universidade Federal do Ceará, Campus Sobral	https://ensaiosclinicos.gov.br/rg/RBR-5kyg2r	<NULL>	both genders; age between 18 and 60 years; clinical diagnosis of localized alopecia areata, with less than 25% area of hair loss; presence of an alopecia patch with a larger diameter between 2 and 5 cm	any form of therapy for alopecia areata in the past 3 months; use of systemic corticosteroids or immunosuppressive drugs; illness or condition that causes immunosuppression; rapidly progressive disease; presence of another cause of alopecia; presence of an inflammatory process in the alopecia patch; history of allergy to corticosteroids; pregnancy or lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-4dbvt7	Effectiveness of bleaching using violet led light	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3544	Effectiveness of bleaching with led photobleaching: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal do Amazonas - Faculdade de Odontologia	Universidade Federal do Amazonas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-4dbvt7	<NULL>	Patients will be included in this clinical trial were men and women over 18 years; who were in good general and oral health; were required to have six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade C2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Patients will be excluded pregnant or lactating women; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); orthodontic appliance users; gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4kzgt4	Effectiveness of bleaching with carbamide peroxide using sonic ativation and genetic toxicity	Data analysis completed	Intervention	2019-10-22	<NULL>	<NULL>	3120	Effectiveness of bleaching with 37% carbamide peroxide with and without sonic activation and genotoxic effect: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal do Amazonas - Faculdade de Odontologia	Universidade Federal do Amazonas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-4kzgt4	<NULL>	Patients included in this clinical trial were men and women over 18 years; who were in good general and oral health; with six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade C2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Pregnant or lactating patients were excluded; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); orthodontic appliance users; gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-3zzqsfh	Effectiveness of Blue Led to treat Vaginal Candidiasis: randomized controlled trial	Recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7090	Effect of blue led in the treatment of Recurring Vaginal Candidíasis: randomized controlled trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade Federal do Delta do Parnaíba UFDPAR	Universidade Federal do Delta do Parnaíba UFDPAR	https://ensaiosclinicos.gov.br/rg/RBR-3zzqsfh	<NULL>	The research will include women; aged between 18 e 40 years; residing in the Coastal Plain; with a proven medical diagnosis of recurrent vaginal candidiasis;  who have steady partners; are not pregnant or in menopause;  are not immunocompromised patients or undergoing oncological treatment; are not undergoing use of metronidazole or other medication that may interfere with the vaginal microflora; do not present lesions in the Pap smear; and have good cognitive and verbal conditions, and who agree to participate in the research, after reading, understanding and signing the Free and Consent Form Clarified - TCLE	Volunteers will be excluded from the research if they have infections of other types; are treated for candidiasis with other modalities at the time of the research; if their partners do not undergo the associated treatment;  if they request to withdraw from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-10h66vr4	Effectiveness of Bodybuilding combined with Vitamin D supplements on Cognition, Autonomy and Quality of Life in the elderly	Recruitment completed	Intervention	2025-10-07	<NULL>	<NULL>	8378	Effects of Muscle Strength Training combined with Vitamin D Supplementation on Executive Functions, Functional Autonomy and Quality of Life in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade do Estado do Rio de Janeiro	Laboratório de Atividade Física e Promoção da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-10h66vr4	<NULL>	minimum age 60 years; healthy; sedentary; without the use of vitamin D supplementation	have some physiological impairment that inhibits or reduces the absorption of vitamin D; have any medical restrictions on taking Vitamin D supplementation; score lower than 26 on the Mini Mental State Examination; Do not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-57m3wnw	Effectiveness of Buzzy® and Pikluc® in relieving pain associated with intramuscular injection in children	Recruiting	Intervention	2024-05-22	<NULL>	<NULL>	7019	Effectiveness of Buzzy® and Pikluc® in relieving pain associated with intramuscular injection in children: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Programa de Pós-Graduação em Enfermagem da Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão da Secretaria de Estado da Saúde de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-57m3wnw	<NULL>	To be in the age range of 1 to 11 years, 11 months, and 29 days old. Have a medical prescription for intramuscular injection	Child with Raynaud&apos;s disease or other vasospastic disorders. Hypersensitivity to cold. Cardiac disorders with impairment of local circulation. Rheumatoid disease. Hypertensive disease. Anesthetized skin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-10w3kwxt	Effectiveness of Cognitive-Behavioral Therapy for adults with anxiety symptoms	Recruitment completed	Intervention	2024-05-28	<NULL>	<NULL>	7034	Online intervention in cognitive-behavioral therapy in adults with anxiety symptoms: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-10w3kwxt	<NULL>	Participants aged between 18 and 60 years old; who present symptoms of anxiety; have internet access; and agree to participate in the research by signing the Informed Consent Form; without restrictions regarding race, gender and sexual orientation	Participants not meeting the inclusion criteria; with a history of severe mental disorders (schizophrenia, bipolar disorder); currently undergoing psychotherapeutic treatment at the time of study inclusion; illiterate individuals; experiencing communication difficulties that compromise the understanding of the proposed interventions; engaging in abusive use of psychoactive substances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-2ny7pqt	Effectiveness of comparing virtual reality and therapeutic exercises via videoconference on active behavior, emotional perception and sensation of effort in older persons during the new Coronavirus period	Recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8554	Effect of comparing game to virtual environment and physiotherapy conventional teleservice on physical activity, mood state and perception of exertion in elderly people during Covid-19 pandemic	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-03	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Both sexes; age between 60 and 80 years; in home isolation; internet access with notebook and cell phone; presence of family member or caregiver nearby; no restrictions on movement in the upper limbs	Those who give up participating during the protocol; do not understand the commands necessary to perform the tests in the familiarization phase; are unable to perform the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:14
RBR-94pj2d	Effectiveness of computed tomography in face fracture diagnosis	Data analysis completed	Intervention	2020-05-25	<NULL>	<NULL>	3870	Effectiveness of computed tomography with three-dimensional reconstruction in the diagnosis of panfacial fractures	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-94pj2d	<NULL>	Suspected fractures of the middle third of the face requiring computed tomography for diagnostic purposes.	Patients referred with CT already performed in another hospital and patients with a past history of facial fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-2rm2w3k	Effectiveness of Continuous Lateralization Therapy for reducing pulmonary complications and pressure injuries in critically ill patients.	Recruiting	Intervention	2023-12-15	<NULL>	<NULL>	6660	Effectiveness of Platform-Based Lateralization Therapy in reducing interface pressure between the patient and the support surface	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-2rm2w3k	<NULL>	Adult and elderly patients, aged 18. Both genders. Patients at risk of developing Pressure Injury-  PI (Braden Scale score less than or equal to 18). Patient under controlled/assisted mechanical ventilation not yet eligible for weaning	Need for norepinephrine &gt; 1mcg/kg/min or mean arterial pressure &lt; 60 mmHg. Cardiac arrhythmias. Neurological diseases or symptoms, such as a history of seizures. Dependence on cardiac pacemaker. Air escape through chest drains, pneumothorax or undrained subcutaneous emphysema. Presence of previous Pressure Injury - PI during admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5nqk4k	Effectiveness of Corrective Insoles in the treatment of Diabetic Foot	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2564	Efficacy of Customized Insoles in the treatment of Diabetic Foot: Randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-05	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5nqk4k	<NULL>	Volunteers over 18 years of age; of both sexes; patients with type 2 diabetes mellitus; carriers of typical diabetic neuropathy; with increased plantar pressure in the forefoot region.	Patients with fasting glycemia below 100 mg / dl and HbA1c below 5.7% in the absence of treatment; patients with movement disorders; previous history of stroke; orthopedic surgeries or ulceration and amputation of lower limbs; pregnant women; patients in whom complete and adequate physical examination was not possible; patients with balance difficulties; patients who can not move alone; patients who have another cause of neuropathy; patients who do not attend for laboratory or non-laboratory tests and who choose to give up the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-5n8sn7b	Effectiveness of Cupping use on Muscle Pain in recreational amateur Runners: randomized clinical trial	Recruitment completed	Intervention	2023-08-07	<NULL>	<NULL>	6315	Effectiveness of Cupping Therapy on Muscle Pain in recreational Runners: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5n8sn7b	<NULL>	Ages of 18 and 59; without gender restrictions; who have been running for at least two months and can cover a distance of ten kilometers without interruption.	Self-report musculoskeletal pain at the time of the evaluation; have a difference greater than 1.5 cm in lower limb size will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-89cp93	Effectiveness of dental care for prevention of nosocomial respiratory tract infections among intensive care patients.	Data analysis completed	Intervention	2016-12-22	<NULL>	<NULL>	1110	Effectiveness of dental care for prevention of nosocomial respiratory tract infections among intensive care patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89cp93	<NULL>	Patients of both sexes, aged between 18 and 100 years old, admitted to the ICU of the study, if they had a expected time of hospitalization exceeding 48 hours.	Pregnancy, blood dyscrasia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-4w8tdb	Effectiveness of Dentifrice with Fluoride Controlled-release System for Remineralization of White spot: Randomized clinical study	Data analysis completed	Intervention	2019-06-17	<NULL>	<NULL>	2765	Effectiveness of Dentifrice with Fluoride Controlled-release System for Remineralization of White spot: Randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Federal da Paraíba	Savoy	https://ensaiosclinicos.gov.br/rg/RBR-4w8tdb	<NULL>	Age of 10 to 16 years that accept to participate of the research (agreement of agreement) and with consent of the parents or responsible ones (TCLE); has at least one lesion of active white spot on the vestibular face.	orthodontic appliance users; have extensive caries lesions or tooth sensitivity; children who do not allow the clinical examination. Also excluded are children and adolescents who are not residents of the metropolitan area of João Pessoa or exposed to drinking water from wells or sources other than the city&apos;s supply network	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-5qrt8h	Effectiveness of denture adhesives in chewing of complete denture wearers	Data analysis completed	Intervention	2012-05-08	<NULL>	<NULL>	243	Effectiveness of denture adhesives on the kinesiographic records and satisfaction of complete denture wearers	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-10	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5qrt8h	<NULL>	"Adults;
Mentally agile and responsive;
Resilience and alveolar volume normal; Absence of dysfunctions in the stomatognathic system;
Absence of debilitating systemic changes."	"Debilitating neurological or systemic diseases;
Cardiac pacemaker;
Need for pre-prosthetic surgery."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-7yrr3s	Effectiveness of desensitizing in reducing tooth sensitivity	Recruitment completed	Intervention	2016-08-16	<NULL>	<NULL>	964	"Clinical evaluation of exposure to derivatives glue and sensitivity after whitening
Dental vital teeth"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-14	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-7yrr3s	<NULL>	healthy volunteers; aged 18-40 years anterior teeth with upper and lower vitality; free of decay and restorations on the labial face without cervical lesions; absence of periodontal disease; non-smoking. initial color of at least one tooth is A2 or darker.	Volunteers who have made tooth whitening; using desensitizing folders or product that prevents sensitivity; pregnant women; nursing mothers; presenting teeth staining; endodontic treatment; dental sensitivity; Bruxist; use of medications such as analgesics and anti-inflammatories; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-3p54y6r	Effectiveness of different concentrations of potassium nitrate on dental sensitivity at whitening	Recruitment completed	Intervention	2021-10-09	<NULL>	<NULL>	4953	Effectiveness of different concentrations of potassium nitrate on dental sensitivity at whitening: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Faculdade de Odontologia da Pontifícia Universidade Católica do Rio Grande Do Sul	Faculdade de Odontologia da Pontifícia Universidade Católica do Rio Grande Do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3p54y6r	<NULL>	Patients included in this clinical trial were at least 18 years old and had good general and oral health. Participants held the minimum of 24 teeth and no restorations in incisors, canines and premolars. In addition, they had to have shade greater than A2, B2, C2 and D2 dental pigmentation.	Excluded patients were those who out of the potential participants underwent tooth-whitening procedures; were pregnant or lactating; had cracks, cervical lesions, exposed dentin or a history of dentin hypersensitivity; previous (last 3 months) use of desensitizing agent or anti-inflammatory drugs; and any mouth gross pathology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-87wb8x5	Effectiveness of different nutritional treatments for the health care of women with Obesity in Viçosa-MG	Recruitment completed	Intervention	2024-06-05	<NULL>	<NULL>	7047	Evaluation of the effectiveness of nutritional interventions for the health care of women with Obesity in Viçosa-MG	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal de Viçosa	Prefeitura Municipal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-87wb8x5	<NULL>	Women between the ages of 18 and 60; with a BMI greater than or equal to 25 kg/m2; who are not currently engaged in any other method of weight control	The exclusion criteria were: current pharmacological treatment for obesity; have serious medical or psychiatric conditions; insulin-dependent diabetes; be pregnant, breastfeeding or intending to become pregnant during the study period; have untreated hypothyroidism or hyperthyroidism; practicing mindfulness, meditation, yoga or similar practices in the previous 6 months (with formal practice at least once a week); having had any type of bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-9bjhhyt	Effectiveness of different techniques for bonding parts of orthodontic appliances	Recruitment completed	Intervention	2024-03-18	<NULL>	<NULL>	6858	Comparison of the effectiveness between Direct and Virtual Indirect Bonding of brackets in orthodontic alignment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Anhanguera educacional participaçoes S/A	UNIC - Universidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-9bjhhyt	<NULL>	Ages between 12 and 35 years old; of both sexes; complete permanent dentures; need of orthodontic treatment; mild to moderate crowding; Class I or Class II Angle malocclusions; good oral hygiene; good periodontal condition.	Patients who require surgical treatment to correct a skeletal discrepancy; have already undergone prior orthodontic treatment; agenesis; hypodontia; hyperdontia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-10h7khvk	Effectiveness of distance exercises associated with self management booklet in patients with neck pain	Recruiting	Intervention	2022-09-16	<NULL>	<NULL>	5614	Effectiveness of telerehabilitation exercise program versus online self management booklet on pain and disability in patients with non-specific chronic neck pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-10h7khvk	<NULL>	Age between 18 and 60 years; of both genders; presence of cervical spine pain of at least 3 points on the numerical pain scale from 0 to 10; have access to the internet and ability to read and understand the portuguese language	Presence of severe musculoskeletal, cardiovascular and metabolic disorders; history of neurological injuries; use of muscle relaxants; obesity; presence of red flag with weight loss without apparent cause, fever and moderate to severe trauma; any health condition that makes it impossible to exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-6rzh4h2	Effectiveness of Dry needling as a treatment for long lasting Tinnitus	Data analysis completed	Intervention	2024-05-22	<NULL>	<NULL>	7018	Effectiveness of Dry needling as a treatment for Chronic tinnitus	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Hospital Edmundo Vasconcelos / Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	Hospital Edmundo Vasconcelos / Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	https://ensaiosclinicos.gov.br/rg/RBR-6rzh4h2	<NULL>	Patients over 18 years old; tinnitus for at least 3 months; trigger points on physical examination	Pulsatile tinnitus; coagulopathy or anticoagulant use; dermatological lesion at the needling site; pregnancy; needle phobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-297fzx	Effectiveness of educational intervention in adherence to postoperative care of stomach reduction surgery	Recruitment completed	Intervention	2018-06-06	<NULL>	<NULL>	1875	Effectiveness of educational intervention in adherence to postoperative care in bariatric surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-297fzx	<NULL>	Patients enrolled in the obesity program of the study institution; experiencing immediate preoperative; literate.	Patients using the intragastric balloon; without time availability; without a landline or mobile phone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-3n4tzc	Effectiveness of educational primer for caregivers of stroke patients.	Recruiting	Intervention	2018-12-10	<NULL>	<NULL>	2372	Effect of educational primer for caregivers of stroke victims: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-31	Universidade Estadual do Ceará -  UECE	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-3n4tzc	<NULL>	Age greater than or equal to 18 years; be a ccompanying the patient during the period of hospitalization; be one of the main caregivers of the patient after discharge; and have at least one telephone contact for the researcher to contact to carry out the other phases of the research.	Caregivers who present some mental impossibility to understand interventions and those who cannot read and write. Cases of discontinuity will be considered: telephone change after follow-up, failure to answer telephone call safter three attempt sat different day sand times, caregiver whose cell phoneis out of area or disconnected for more than 10 attempts to connect in days and schedules and no longer be the caregiver of the patient suffering from stroke. The patient or caregiver who died in the course of the research will be considered a loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-2sgn9cy	Effectiveness of educational software in the teaching-learning of nursing students on infant development	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7379	Effectiveness of Wise Infant Development® software in the acquisition of knowledge about infant development among nursing students: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal do Ceará	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-2sgn9cy	<NULL>	Both sexes; be at least 18 years old; be regularly enrolled in the educational institution; be a nursing student; not currently taking or having taken the child health course; have basic computer skills	Students absent due to medical leave or maternity leave; students who are already nursing technicians; obtain a score equal to or greater than 70% in the pre-test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-95f8kf8	Effectiveness of educational technology on father participation in labor, delivery, and birth	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8636	Effectiveness of educational technology on paternal participation in labor, delivery, and birth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Maternidade Escola Assis Chateaubriand da Universidade Federal do Ceará	<NULL>	<NULL>	<NULL>	Minimum age of 18 years; be a partner and the companion of the parturient&apos;s choice; first experience in accompanying labor; have completed at least the fourth year of elementary school; and be accompanying nulliparous pregnant women, with a live fetus, at term, with a medical diagnosis of labor or antepartum rupture of the ovular membranes or hypertensive or postpartum syndromes, for induction of labor and who have an indication for vaginal delivery regardless of the obstetric outcome, which may be vaginal or cesarean section	Parturients in the expulsive stage; presenting a compromised physical or mental health condition that makes the research unfeasible; having participated in parenting and/or pregnancy courses; being a health professional; having the presence of doulas; parents with communication difficulties and stillbirth; giving up on continuing to participate in the study after the start of data collection; progressing to labor at the time of the approach; giving up or being unable to answer the proposed questions and stillbirth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-5qywrf	Effectiveness of effect of relaxation therapy with guided imagery on anxiety and pain in patients undergoing stomach reduction surgery	Recruitment completed	Intervention	2017-06-12	<NULL>	<NULL>	1970	Relaxation therapy with guided imagery on anxiety and pain in patients undergoing bariatric surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-18	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5qywrf	<NULL>	Patient submitted to bariatric surgery by videolaparoscopy.	Patient who presented hearing deficit or alterations; patient who was not in a position to maintain dialogue with the researcher after the end of the effects of anesthetic drugs and patient who received preanesthetic and / or anxiolytic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-4zdbbq	Effectiveness of elastic bandage in sedentary women with knee pain.	Data analysis completed	Intervention	2016-09-20	<NULL>	<NULL>	1011	The clinical efficacy of Kinesio Tape for Patellofemoral Pain Syndrome in sedentary women.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-4zdbbq	<NULL>	"Female patients , aged between 18 and 43 years;
Clinical diagnosis of PFPS , unilateral or bilateral;
Inactive or irregularly active , according to the criteria of the International Physical Activity Questionnaire ( IPAQ );
History of anterior knee pain for at least 3 months;
Report increased pain in at least two activities related to PFPS , such as up and down stairs , jump , kneel , stand with the knee flexed for long periods or pain palpation of the medial or lateral facet of the patella;
BMI &lt; 29.9 ."	"Osteoarthritis in any degree;
Previous surgery in the lumbar spine , hip, knee , ankle or foot;
BMI&gt; 29.9;
Active or very active, according to the IPAQ criteria;
Patellar or quadriceps tendinopathy;
Patellofemoral instability ( PFI );
Traumatic or atraumatic patellar dislocation;
Ligamentar or meniscal lesion diagnosed clinically or by complementary exams;
Sensitivity to the material used ."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-559x2b3	Effectiveness of electroacupuncture and laseracupuncture in the health of post-covid-19 patients: randomized clinical trial	Not yet recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5319	Effectiveness of electroacupuncture and laseracupuncture in the health of post-covid-19 patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-559x2b3	<NULL>	Age between 18 and 59 years; history of positive testing for SARS-Cov-2; with new or persistent symptoms since the acute phase of the disease lasting at least two months, unexplained by an alternative diagnosis; that has one or more of the following characteristics: altered spirometry parameters; fatigue score greater than 4; anxiety score equal to or greater than 11; score on the depression scale equal to or greater than 8; not having a contraindication factor for performing electroacupuncture and laseracupuncture; not being on specific clinical treatment for the post-COVID-19 syndrome; present agreement with the Free and Informed Consent Form signed in two copies; agree to participate in the proposed tests.	Institutionalized people; who do not present the signature of the Free and Informed Consent Form; who do not fit into the aforementioned age group; history of carcinoma; neoplasms; physical disability; motor and/or cognitive; use of metallic prostheses; pacemaker; photosensitivity history; contraindication for the use of photobiomodulation (melanin changes; history of burns); current treatment/follow-up other than usual care. Pregnant women, people with severe mental disorders, risk of suicide attempt, people with hormonal disorders, people who are under any therapeutic intervention of traditional Chinese medicine will also not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-10xsbmmb	Effectiveness of Exercise and Education via Telehealth in Patients with Back Pain	Not yet recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7103	Efficacy and equity of exercise combined with education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-21	Universidade Federal dos Vales de Jequitinhonha e Mucuri	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10xsbmmb	<NULL>	Patients of both genres; over the age of 18; who have had non-specific low back pain for at least 3 months; disability scores of 4 out of 24 points or more on the Roland Morris Disability Questionnaire; and pain intensity scores of 3 out of 10 points or more on an 11 point Numerical Pain Scale; able to read and understand Portuguese; and with internet access	Suspected or confirmed severe spinal pathology (fracture, metastatic, inflammatory or infectious diseases of the spine, cauda equina syndrome/generalized neurological disorder); radiculopathy, grade 2 affected strength, reflex, or sensation to the same nerve root; previous history of spine surgery in the last 12 months; scheduled for major surgery during the study or follow up period; pregnancy; and contraindications to exercise listed in the American College of Sports Medicine guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-9tqr2jt	Effectiveness of Exercise In Neck Pain due to Whiplash Associated Disorders	Not yet recruiting	Intervention	2021-12-15	<NULL>	<NULL>	5112	Exercise-Induced Hypoalgesia in Acute/Subacute Whiplash Associated Disorders: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	University of Seville	University of Seville	https://ensaiosclinicos.gov.br/rg/RBR-9tqr2jt	<NULL>	Inclusion criteria are aged between 18-65 years, have sustained a whiplash injury within the last 7 and 30 days, diagnosis of WAD grade IIaccording to Quebec Task Force	Exclusion criteria are WAD grade I, III or IV injury (neurological deficit, fracture or dislocation), presence of previous generalized pain or neuropathic pain condition, nerve root compromise (at least 2 of the following signs: weakness/reflex changes/sensory loss associated with the same spinal nerve), loss of consciousness after the accident, instability signs, psychiatric disorders, inflammatory or rheumatic disease, or tumours, previous surgery in the cervical or upper limbs region, previous whiplash injury, unwilling to perform a prescribed exercise intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-9dvpr4	Effectiveness of Exercise in Water on physical and functional performance in people with Chronic Back Pain	Data analysis completed	Intervention	2017-12-01	<NULL>	<NULL>	1509	Effectiveness of Aquapilates on physical and functional performance in patients with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9dvpr4	<NULL>	"Age of 50 to 70 years;
Present non-specific low back pain for more than 3 months;
Have not undergone any surgery in the spine or other surgeries that make the exercises impossible;
Do not present any infection or neoplasms;"	"Individuals who had surgery on the spine;
Have heart failure or any other heart disease;
Chlorine allergy;
Hydrophobia;
Absence of sphincter control;
Neurological disorders;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-6b4zwx3	Effectiveness of Exercise on side effects related to Cancer treatment with Chemotherapy: clinical study with economic evaluation	Recruiting	Intervention	2023-06-20	<NULL>	<NULL>	6875	Effectiveness of Aerobic Training in Chemotherapy-related adverse symptoms during treatment: controlled and randomized trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Cidade de Sao Paulo	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-6b4zwx3	<NULL>	Patients over 18 years of age; both genders; diagnosed with cancer and hospitalized in the Clinical Oncology ward of the Institute for Medical Assistance to State Public Servants, São Paulo-SP, to undergo at least one cycle of chemotherapy. Patients without musculoskeletal; cognitive or clinical limitations that interfere with the proposed evaluations and interventions, such as: heart diseases (moderate to severe aortic or pulmonary stenosis; decompensated heart failure; advanced cardiac arrhythmias; myocarditis; unstable coronary insufficiency, for example) will be included in the study; pneumopathies (chronic obstructive pulmonary disease and/or decompensated asthma, for example); diabetes mellitus; decompensated systemic arterial hypertension; serum hemoglobin (Hb) &lt; 8g/dL or hematocrit (Ht) &lt; 25% or platelets &lt; 30,000 mm	Patients expected to be hospitalized for less than three days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-6sx3sz	Effectiveness of gargle and nasal spray with Hydrogen Peroxide as an auxiliary treatment for corona virus	Terminated	Intervention	2020-07-29	<NULL>	<NULL>	4799	Effectiveness of Hydrogen Peroxide administration in the form of gargle and nasal spray as an auxiliary treatment for suspected and infected patients with SARS-VOC-2	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2020-06-26	Programa de Pós-Graduação em Odontologia da Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-6sx3sz	<NULL>	For the index case: test positive for SARS-CoV-2; having received a positive diagnosis less than three days ago; being hospitalized or undergoing home treatment; have the physical capacity to gargle and apply the nasal spray on their own; have moderate or mild symptoms of breathing problems, or have no respiratory symptoms; accept to participate in the study; sign the consent form. For family members of the index case: live in the same household as the individual who tested positive for SARS-CoV-2; have the physical capacity to gargle and apply the nasal spray on their own; have moderate or mild symptoms of breathing problems, or have no respiratory symptoms; accept to participate in the study; sign the consent form.	For index cases: being a smoker; be hospitalized in ICU. For family members in the index case: being hospitalized or having sought hospital care with symptoms suggestive of Covid-19 prior to the index case; have tested positive for Covid-19 before the index case.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-4d3kvz5	Effectiveness of Genicular Block image guided with Phenol for the treatment of Chronic Pain due to Knee Ostheoarthritis	Recruiting	Intervention	2022-12-06	<NULL>	<NULL>	5757	Randomized-controlled trial of the effectiveness of Genicular nerve block image guided with Phenol for the treatment of Chronic Knee Pain due to Knee Ostheoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4d3kvz5	<NULL>	"Severe knee pain with pain greater than 6 on the numerical rating scale ;
Knee osteoarthritis  Kellgren-Lawrence classification  2 to 4, uni or bilateral;
More than six months without improvement with conservative treatment"	Patients with cognitive impairment ; Psychiatric illnesses; Other causes of knee pain (trauma, complex regional pain syndrome, rheumatoid arthritis or lumbosciatalgia or sciatica); Puncture site infection; Coagulopathy; Anticoagulant use; Body Mass Index &gt;40kg/m2; Previous Total Knee Arthroplasty	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-2v7d2v4	Effectiveness of green tea and hyaluronic acid in post-tooth extraction repair in patients undergoing radiotherapy	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8629	Effectiveness of green tea and hyaluronic acid in post-extraction repair in patients undergoing radiotherapy	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-17	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with head and neck cancer, of both sexes, over 18 years of age, who require tooth extractions in the context of radiotherapy treatment, either prior to its initiation or afterwards, due to oral cavity preparation or dental emergencies. All participants must agree to take part in the study and provide their signature on the Informed Consent Form	Severely debilitated patients, those who do not accept or do not sign the Informed Consent Form, pregnant or breastfeeding women, individuals with metallic artifacts that impair tomographic analysis, and those who present periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-4qmypqq	Effectiveness of HCV treatment by non-specialists (general practicioners or family-doctors) compared to specialists (hepatologists, gastroenterologists or infectious disease doctors) in the brazilian public health system	Not yet recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4929	Randomized open-label and non-inferiority clinical trial to evaluate treatment retention, safety and cost-effectiveness of simplified and decentralized HCV treament compared to standard-of-care in the brazilian public health system	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2021-12-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4qmypqq	<NULL>	Age between18 and 79 years-old; presence of chronic hepatitis C	Pregnancy; HBV co-infection; HIV co-infection; use of medications with potential interaction with SOF/VEL; presence of acute disease, neoplasm, solid organ transplant or use of immunossupressor; presence of clinical signs of decompensated cirrhosis; refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-5cjpz86	Effectiveness of hot tub bath in pain of hospitalized children	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5649	Effectiveness of hot immersion bath in pain management of hospitalized children: Randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5cjpz86	<NULL>	Children who meet the following criteria will be included in the study: Children between 28 days and 2 years old, hospitalized in the Pediatric Inpatient Unit/Ward for respiratory problems; Children with pain, evaluated by validated scales: Neonatal Infant Pain Scale (NIPS), whether it is: severe, moderate or mild pain; or Face, Legs, Activity, Cry, Consolability (FLACC), be it: severe, moderate or mild pain; Have the permission of their parents or guardians to participate in this study. In addition to these criteria, the inclusion of the same child within 12 hours of the last inclusion in the study will also be allowed if the child is not under the influence of pain management medications and the last medication for this purpose was taken within 6 hours, considering the time of action of the most used drugs.	Exclusion criteria will be: Children over 2 years of age; Children using positive pressure ventilation (CPAP); Children awaiting transfer to the Intensive Care Unit (ICU) due to worsening respiratory distress, since the immersion bath can cause crying and irritability and the condition worsens; Children who have taken any medication for pain management within 6 hours of pain detection using the validated scales; Children with a previous diagnosis of chronic pain. It is worth mentioning that there are medications that are used both for pain management and for other conditions, for example dipyrone, which in addition to being an analgesic also has antipyretic properties, and can be used in the management of fever. Thus, the researcher at the time of collection will pay attention to the medications that were previously administered to the child and whether they have analgesic properties, in order to avoid inclusion bias. If they also act in pain management, the medication must have been administered within a 6-hour interval prior to the moment of pain detection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-8v9gr9c	Effectiveness of Ice application in acute ankle sprain treatment	Recruiting	Intervention	2023-02-03	<NULL>	<NULL>	7725	Effectiveness of Cryotherapy on function, pain intensity, swelling, dorsiflexion range of motion in Acute Ankle Sprain: a randomized controlled trial - the frost study	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-03-03	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Hospital Nossa Senhora da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8v9gr9c	<NULL>	People of both sexes aged between 18-60 years old; clinical diagnosis of grade I or II ankle sprains, indicating an incomplete ligament rupture; time of up to 72 hours from the episode of the injury to the day of the medical appointment; bone fractures excluded by radiography or by the Ottawa ankle rules	Grade III (severe) ankle sprain, indicating complete ligament injury, determined by a clear positive test of the anterior drawer and / or inversion stress test, accompanied by severe swelling, hemorrhage, high level of pain on palpation, in addition to total loss of the ability to support weight on the foot and of the dorsiflexion range of motion; open injuries that contraindicate the application of ice; having applied some form of cryotherapy more than once since the moment of the injury until the allocation process; apply some form of cryotherapy after being assigned to the control group; have any conditions that contraindicate the application of ice (e.g. Raynaud&apos;s syndrome), or any other intervention prescribed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-9zn76ph	Effectiveness of ice pack and hot pack on the snakebite site	Recruiting	Intervention	2023-01-10	<NULL>	<NULL>	5811	Effectiveness of intervention at the site of botropic poisoning by means of ice and hot compresses: open randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-07	Universidade do Estado do Amazonas	Fundação de Medicina Tropical Dr. Heitor Vieira Dourado	https://ensaiosclinicos.gov.br/rg/RBR-9zn76ph	<NULL>	Patients of both sexes with Bothropic snake envenomation within a maximum of 24 hours of evolution; age greater than 18 years	Patient with bleeding with systemic and local repercussions at the time of recruitment; patients who used ice or hot packs before arriving at the hospital	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-483ndsd	Effectiveness of immersive Virtual Reality on pain perception in children associated with vaccination: randomized pilot study	Data analysis completed	Intervention	2024-03-05	<NULL>	<NULL>	6829	Effect of Virtual Reality on children&apos;s pain perception during vaccination: pilot study of a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-483ndsd	<NULL>	Children between four and six years, 11 months and 29 days; any ethnicity; both sexes; accompanied by parents or legal guardian; received at least one of the five vaccines recommended for the age group; presented cognitive and emotional conditions that enabled the application of the data collection instrument	Child with visual impairment or significant reduction in visual acuity; epilepsy/seizure; pre-existing migraines; changes in sensitivity (decrease or increase) that generated discomfort during the use of virtual reality glasses (labyrinthitis); children with psychiatric illnesses; mood changes diagnosed in an acute state (anxiety and phobias); children with infections; burns or injuries to the face or head that interfered with putting on the immersive virtual reality glasses; strabismus; change in bone shape that made it difficult to adapt virtual reality glasses; having undergone an invasive procedure on the same day as vaccination, withdrawal of participation by the child or parents/legal guardian; presence of nausea; vomiting or other discomfort during the intervention with the immersive virtual reality glasses that did not allow the continued use of the virtual reality glasses; children who used oral, intramuscular or topical (at the site of the intramuscular procedure) analgesics (in less than 12 hours); wished not to use the immersive virtual reality glasses during the intramuscular vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-274vf96	Effectiveness of in-office dental bleaching in adolescents using 6% hydrogen peroxide with different application tips	Recruitment completed	Intervention	2021-12-14	<NULL>	<NULL>	5110	Effectiveness of in-office dental bleaching in adolescents using 6% hydrogen peroxide with different application tips: randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-12	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-274vf96	<NULL>	Age between 12 and 16 years old; good general and oral health; healthy vital teeth; minimum color A2; their guardians agree and sign the informed consent form (TCLE).	Previously bleaching procedure; prior dental sensitivity; dental prosthesis; fixed orthodontic appliance; restorations in the upper anterior teeth; presence of deciduous teeth; endodontic treatment of maxillary anterior teeth; gingival recessions; teeth stained by tetracycline or fluorosis; visible cracks in teeth; continuous use of medications; pregnant or lactating women; bruxism; smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-9k8ymkm	Effectiveness of in-office dental bleaching using 35% hydrogen peroxide with different application tips	Recruiting	Intervention	2022-07-13	<NULL>	<NULL>	5482	Effectiveness of in-office dental bleaching using 35% hydrogen peroxide with different application tips: randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-04	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9k8ymkm	<NULL>	Minimum 18 years of age; in good general and oral health; teeth free of carious lesions; without gingival recession and periodontal disease in the anterior region; who agree with the Free and Informed Consent Form (TCLE) and one of their canines should be A2 or darker in color according to the Vita Classical scale	Whitening procedure previously; previous dental sensitivity; dental prosthesis; fixed orthodontic appliance; restorations in the anterior superior teeth; endodontic treatment on anterosuperior teeth; gingival recessions; teeth stained by tetracycline or fluorosis; visible cracks in the teeth; continuous use of medications; pregnant or lactating women; bruxism; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-9ngd4mm	Effectiveness of Interpersonal Relationships in Anxiety Situations (RIA) in Primary Health Care: A Randomized Clinical Trial	Recruitment completed	Intervention	2025-12-11	<NULL>	<NULL>	8642	Mental health and psychosocial care during the Covid 19 outbreak: proposal for a telephone based intervention program for controlling anxiety and reducing alcohol consumption	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-01	Secretaria Municipal da Saúde de São Paulo	<NULL>	<NULL>	<NULL>	to be male or female; to be over 18 years old; to have attended a consultation at the Basic Health Unit (BHU); to have sufficient proficiency in the Portuguese language to understand the interviewer’s questions; to have a score equal to or greater than 11 on the simplified 6-item State-Trait Anxiety Inventory (STAI-S6); to be available for follow-up	undergoing treatment for problems related to alcohol use and/or other mental disorders; patients who show noticeable signs of mental confusion or intoxication by psychoactive substances during the phone call; the hearing impaired; patients who refuse to receive the intervention and/or follow-up	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-5p7kbh2	Effectiveness of intervention to Improve Adherence to Home Care of suspected or confirmed mild cases of Covid-19	Recruiting	Intervention	2021-06-28	<NULL>	<NULL>	4765	Evaluation of the effectiveness of intervention with text messages to support home isolation of suspected cases of Covid-19 identified in primary care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-5p7kbh2	<NULL>	Volunteers diagnosed with flu syndrome; suspected or confirmed of Covid-19, considered a mild case; have indication of home isolation; age 18 years or older; be literate; have a mobile device for personal use; be able to read text message; answer the call from the cell phone itself	Volunteers who do not answer the research team&apos;s phone call after three attempts to contact; answer the phone and do not wish to continue participating in the survey; someone else answers the phone and the participant is not found	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-3ypfxv	Effectiveness of Intragastric balloon associated with diet on treatment of patients with type 2 diabetes	Recruitment completed	Intervention	2017-05-04	<NULL>	<NULL>	1223	Evaluation of Intragastric Balloon effectiveness associated to diet on treatment of diabetic patients with BMI&lt;35	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-01	Faculdade de Medicina da Univesidade de São Paulo	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3ypfxv	<NULL>	Volunteers males or females, age between 21 and 59 years; Overweight or obesity grade I (BMI between 27 and 34.9); Non-insulin dependent Diabetes Mellitus, glycated hemoglobin &lt;10%, anti-GAD 65 &lt;10 and peptide C&gt; 1; Previous esophagogastroduodenoscopy with negative Helicobacter pylori research; Approval of psychological and nutritional profile; Clinical / drug and behavioral treatment directed to overweight patients, with no success; Signed informed consent form.	Contraindications to treatment with intragastric, clinical or endoscopic balloon; Impossibility of strict follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-8ykm72j	Effectiveness of L carnitine suplementation in COVID-19	Recruiting	Intervention	2021-04-08	<NULL>	<NULL>	4609	Pilot phase II randomized, placebo-controlled clinical trial for the prevention and progression of SARS-CoV-2 infection of subjects and patients using a supplement treatment with LCT	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2021-03-15	Lonza Consumer Health Inc.	SENAI CIMATEC	https://ensaiosclinicos.gov.br/rg/RBR-8ykm72j	<NULL>	"Cohort 1, males and females between 55 years and 85 years of age; history of close contact (cohabit) with a family member or a person newly diagnosed with SARS-CoV-2 infection; negative RT-PCR COVID-19 test on the screening and prior to start treatment .
Cohort 2, males and females between 18 years and  85 years of age;confirmed virology diagnostic of COVID-19; asymptomatic ou mild COVID 19 pneumonia."	"Females of childbearing potential who are pregnant, lactating, or who have not adhered to an adequate contraception method from at least 30 days prior to study entry and who do not plan to do so for at least 1 month post last supplementation;Patients that are doing hormonal replacement therapy;  severe COVID-19 pneumonia according to CDC criteria associated with CT Severe Illness Critical Illness: Individuals who have respiratory failure, septic shock, and/or multiple organ; positive test result  for hepatitis B surface antigen, hepatitis C virus antibody, or human immunodeficiency virus types 1 or 2 antibodies; known or suspected alcohol or drug abuse within the past 6 months prior to screening,participation in another experimental protocol and/or receipt of any investigational products within the past 3 months prior to screening;treatment with immunosuppressive cytotoxic therapies (e.g., chemotherapy drugs or radiation) in the past 6 months prior to screening;patients unable to sign the inform consent to participate into the study;
History of any other acute or uncontrolled chronic illness (including, hypertension, cardiovascular, pulmonary, neurological, hepatic, rheumatic, hematological, metabolic or renal disorders) that is not on medication regimen for at least the past 6 months, or use of medication or supplements that, in the opinion of the Principal Investigator, may interfere with the evaluation of the safety and tolerability of the study drug such as ACE Inhibitors, Angiotensin II Receptor Blockers (ARBs)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:27
RBR-6cf6rp	Effectiveness of lithium microdose in the treatment of Alzheimer&apos;s disease.	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	521	Prospective, double-blind, randomized, placebo-controlled, longitudinal study to evaluate the effectiveness of lithium microdose in the treatment of Alzheimer&apos;s disease.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6cf6rp	<NULL>	Will be included in the study: patients clinical diagnosed with Alzheimer&apos;s disease by the Neurology Department of Medical School of Santa Casa Sao Paulo Hospital, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM, fourth edition), National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and Alzheimer&apos;s Disease and Related Disorders Association; Patients who have a score 1 or 2 in the Clinical Dementia Rating (CDR), characterizing mild and moderate stages of AD, respectively; Patients who are using Alzheimer’s disease FDA-approved drug for at least six months, prescribed by the Neurology Department of Medical School of Santa Casa Sao Paulo Hospital; Patients who have 60 years old or older; Education: everybody could be included in this study, but the years of education must be considered to memory score tests; adjustments should be made in accordance with the scholarity;  Do not include prescription of drugs with central nervous system action in the first six months of treatment, unless strictly necessary conditions and it must be highlighted in the patient evolution; Agreement with and signing of the informed consent form; Having a caregiver (familiar member or formal caregiver) who is responsible for the patient&apos;s participation in the study.	Will be excluded in the study patients who don’t have a clinical diagnosis of Alzheimer&apos;s disease; patients who have a score 3 in clinical dementia rating, i.e. late stage dementia; patients who suffer from diseases that may have contraindications for the use of lithium carbonate, as: kidney failure; patients who have a lithium intolerance; patients who have used lithium for other conditions;  patients with lithium serum levels above the acceptable range, i.e. 1.2 mEq/ L in plasma; patients with renal failure; patients with hypothyroidism or goiter, if not controlled; violation of the protocol; loss of follow-up; discontinuing treatment; by request of patient or caregiver; death; patients who don’t agree to participate in the study. Notes: Frequent and prevalent comorbidities in the elderly are not considered exclusion criteria, such as hypertension, diabetes, vitamin B12 deficiency, among others. These patients will be enrolled in the study with appropriate notes and the possible differences observed in these patients will be compared with normal elderly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-56twgz	Effectiveness of low fat diet for cholesterol control in patients with antiphospholipid syndrome - APS	Recruitment completed	Intervention	2020-02-13	<NULL>	<NULL>	3486	Efficacy of the Hypolipid Diet to control Dyslipidemia in patients with Antiphospholipid Syndrome - APS	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Centro de Hematologia e Hemoterapia de Campinas - Hemocentro	Centro de Hematologia e Hemoterapia de Campinas - Hemocentro	https://ensaiosclinicos.gov.br/rg/RBR-56twgz	<NULL>	"Subjects were selected from patients diagnosed with thrombosis associated with primary APS, followed at the Hemostasis outpatient clinic of the State University of Campinas (UNICAMP). All patients with primary APS and dyslipidemia who had a history of arterial or venous thrombosis of both sexes, aged over 18 years and diagnosed with dyslipidemia were included.
The criteria for the diagnosis of dyslipidemia were: LDL-c above 100mg / dL, HDL-c below 40mg / dL (men) and 50mg / dL (women), TG above 200mg / dL, TC above 190mg / dL , non-HDL cholesterol above 130mg / dL or still on low-fat medications. LDL-c values above 100mg / dL were considered because they were patients with a history of thrombotic disease."	Patients diagnosed with systemic autoimmune disease or neoplasia were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-4xr92k	Effectiveness of Magnesium Sulphate for General Anesthesia in Adults	Recruiting	Intervention	2017-08-02	<NULL>	<NULL>	1314	Effectiveness of magnesium sulphate compared to rocuronium for rapid sequence orotracheal intubation in adult patients	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-07-01	Centro Universitário Tiradentes	Centro Universitário Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-4xr92k	<NULL>	Patient diagnosed with acute appendicitis; Physical status ASA I and II; Age between 18 and 70 years.	Pregnancy; Neuromuscular disease; renal insufficiency; Body mass index greater than 30 km.m-2; Anticipation of difficulty in handling the airway; Chronic use of calcium channel blockers; Chronic use of medicines containing magnesium; Past allergy to magnesium sulfate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-596tn3	Effectiveness of manual lymphatic drainage on lymphedema of the lower limbs compared with the massage technique with smooth movements in reducing lymphedema lower limb.	Recruiting	Intervention	2013-08-31	<NULL>	<NULL>	237	Evaluation of lymphatic drainage and massage  to reduce lymphedema.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-05-01	Vascular Laser Center Ltda-Clinica Godoy	Vascular Laser Center Ltda-Clinica Godoy	https://ensaiosclinicos.gov.br/rg/RBR-596tn3	<NULL>	Patients with lymphedema of lower limbs, clinical diagnostic or lymphoscintigraphy,  without active infection or skin lesion. Both sexs ranging in age from 21 years and maximum 75 years.	Absence of lymphedema, presence of active infection or clinical contraindication for lymphatic drainage such as renal or cardiac decompensation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-7gm9zh	Effectiveness of Mindfulness as an adjunct to treatment in Therapeutic Communities.	Not yet recruiting	Intervention	2019-05-01	<NULL>	<NULL>	2646	Effectiveness of Mindfulness Based Relapse Prevention  as an adjunct to the treatment of substance use disorder: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-17	Universidade Federal de São Paulo UNIFESP	Fundação de Amparo a Pesquisa de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-7gm9zh	<NULL>	Men and women over 18 years of age who are literate (with ability to write and read in Portuguese); who have been on treatment for UUS in one of the services for at least fifteen days; who have consented to be randomized to one of the two groups (control or experimental) .	Patients with psychotic disorders diagnosed by the physician responsible for the services participating in the research or informed by the team for clinical knowledge prior to the patient&apos;s hospitalization; who present severe cognitive impairment that prevents the completion of the scales; patients with suicidal ideation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-3w2scz	Effectiveness of minfulness in comparison to    non-drug standart therapy in smoking cessation	Recruiting	Intervention	2019-10-16	<NULL>	<NULL>	3098	Effectiveness of minfulness in comparison to   cognitive behavioral therapy in smoking cessation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3w2scz	<NULL>	"Active smokers; over 17 years old; living in Curitiba, Brazil; with a current consumption equal or superior to 10 cigarettes a day; that haven´t achieved smoking abstinence for more than three months in the last year; who express a desire to quit smoking and consent to participate in the
study by signing the informed consent form (ICF)."	"The following will be excluded from the study: Alcoholics; drug addicts; patients taking medications for smoking cessation including
buproprion, nicotine in any form of administration and vanericline. Illiterate will also be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-8tsjf97	Effectiveness of Muscle Training and Respiratory Incentives in People Who Have Undergone Cardiac Surgery	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7714	Effectiveness Of incentive Spirometry in a Hospital-based Cardiac Rehabilitation program for patients undergoing Cardiac Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal de Santa Maria	Instituto de Cardiologia do Rio Grande do Sul - Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-8tsjf97	<NULL>	Age over 40 years; preoperative valve replacement; preoperative myocardial revascularization; both sexes	Previous diagnosis of infectious disease; severe uncorrected valvulopathy; severe lesion of the left main coronary artery; congestive heart failure; unstable angina; peripheral neuropathy; nephropathy; severe musculoskeletal disease; morbid obesity; cancer patients undergoing chemotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-6nwvfzd	Effectiveness of Needle and Self-adhesive electro-stimulation in men with Overactive Bladder Syndrome	Recruiting	Intervention	2024-10-07	<NULL>	<NULL>	7406	Eficacy of Percutaneous and Transcutaneous Eletroestimulation in men with Overactive Bladder Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6nwvfzd	<NULL>	Male volunteers; over eighteen years of age; diagnosed with overactive bladder syndrome; complaining of urinary urgency	Volunteers with neurological disease; with severe cognitive impairment; with a psychiatric diagnosis; with a cardiac pacemaker; with calculi; with urethral cysts; with an active lower urinary tract infection; diabetic volunteers with signs of peripheral neuropathy; volunteers taking anticholinergics; volunteers with infra bladder obstruction; with bladder cancer or with a metal plate in the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-55wvt6s	Effectiveness of Non-invasive Neuromodulation associated with virtual gaming in women with Fibromyalgia	Recruitment completed	Intervention	2024-09-19	<NULL>	<NULL>	7356	Effectiveness of Transcranial Direct Current Stimulation (tDCS) associated with Virtual Reality in women with Fibromyalgia: a clinical study randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-18	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-55wvt6s	<NULL>	Female individuals who agreed to participate in the study by agreeing to a Free and Informed Consent Form (TCLE); aged between 30 and 50 years old; and had a clinical diagnosis of Fibromyalgia	Exclusion criteria considered were to female individuals who did not understood or were unable to carry out the proposed activities; patients with cardiac arrhythmias and atrioventricular block; congenital anomalies; lung malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-24vtrb	Effectiveness of nursing intervention to prevent falls in the elderly	Not yet recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3254	Effectiveness of a nursing intervention instrument for fall prevention in hypertensive elderly	<NULL>	n/a, single-arm-study, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-02	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-24vtrb	<NULL>	Elderly with systemic arterial hypertension; have Nursing Diagnosis Risk of falls; being accompanied and registered at the Basic Health Unit I, headquarters II or Boa Fé; have an age greater than or equal to 65 years or greater than or equal to 75 years; live with a partner or family members.	Elderly with diabetes mellitus; have some mental disorder; elderly traveling on the day of recruitment of the survey participants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-5hvgtky	Effectiveness of nutritional intervention to management Systemic Arterial Hypertension in Primary Health Care	Not yet recruiting	Intervention	2021-12-15	<NULL>	<NULL>	5115	Nutritional intervention to control Systemic Arterial Hypertension in Primary Health Care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-03	Universidade Federal de Ouro Preto	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5hvgtky	<NULL>	Both sexes; over 20 years old	Volunteers with cardiovascular disease, angina, heart attack, heart failure, atherosclerosis, peripheral vascular disease, ischemic cerebrovascular disease, chronic liver, kidney or infectious diseases evaluated by medical history; 10% change in body weight two months prior to the study; use of anti-inflammatory drugs; women on exogenous ovarian hormone replacement, pregnancy or breastfeeding; people with special needs; Alzheimer&apos;s disease, dementia or life expectancy shorter than study duration; cognitive difficulties.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-8t7ssv	Effectiveness of nutritional intervention, based on the Trasnteorical Model for weight control, in Primary Health Care services.	Data analysis completed	Intervention	2018-01-31	<NULL>	<NULL>	1611	Effectiveness of nutritional intervention in Primary Health Care belonging to Health Promotion Project - BH + Healthy: Belo Horizonte, Minas Gerais.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-27	Universidade Federal de Minas Gerais - UFMG	Secretaria Municipal de Saúde de Belo Horizonte -SMSBH	https://ensaiosclinicos.gov.br/rg/RBR-8t7ssv	<NULL>	For a definition of eligible criteria, are women; using frequent to service activities (frequent in the last month in physical exercises); to be 20 years old or older; to have obesity for adults - Body Mass Index (BMI) &gt;= 30 kg / m2 (WHO, 1995) and overweight for the elderly - BMI&gt; 27 kg / m2 (NSI, 1992).	Individuals with compromised mental health that prevented responding to the questionnaire and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-8kzvsk	Effectiveness of Ocular Physiotherapy versus Home Exercises in the Convergence Insufficiency	Not yet recruiting	Intervention	2017-07-05	<NULL>	<NULL>	1279	Effectiveness of Ophthalmic Physiotherapy versus Home Exercises in the Convergence Insufficiency	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-03	Faculdade Assis Gurgacz - FAG	Faculdade Assis Gurgacz - FAG	https://ensaiosclinicos.gov.br/rg/RBR-8kzvsk	<NULL>	"Age above 18 years old;
Convergence insuffiency symptons superior 11 from CISS (Convergence Insufficiency Symptom Survey)."	"Neurological diseases;
Ocular diseases under treatment;
Cognitive and behavioral changes."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-7w4cp9	Effectiveness of Osteopathy in Patients with Knee Pain	Data analysis completed	Intervention	2018-09-17	<NULL>	<NULL>	3733	Effects of Osteopathic Manipulative Treatment on Patellofemoral Pain Syndrome of Runners Athletes: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Ceilândia	Faculdade de Ceilândia	https://ensaiosclinicos.gov.br/rg/RBR-7w4cp9	<NULL>	Athlete practicing running; between 18 and 35 years.	Cognitive, musculoskeletal or psychiatric disorders; uncontrolled diabetes mellitus; history of recent infection (last 03 months); use of corticosteroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-10fhfdt4	Effectiveness of Ozone Therapy Treatment of Endometriosis	Recruiting	Intervention	2023-07-06	<NULL>	<NULL>	6211	Effectiveness of Ozone therapy in the signs and symptoms of Endometriosis: controlled and randomizes study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-18	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-10fhfdt4	<NULL>	Women with Endometriosis with laboratory diagnosis; age group between 20 and 50 years; ability to respond to questionnaires; ability to consent to participation in the study and sign informed consent	Volunteers with a history of hysterectomy or oophorectomy; pregnant or breastfeeding women; BMI greater than 30kg/m2 have a history of previous physical abdominal trauma in the last 3 months; use of psychotropic medications; infectious diseases (tuberculosis, leprosy, HIV, systemic fungal diseases) or any other similar condition; severe underlying disease (heart, kidney, liver, lung) or malignancy; diabetes mellitus and decompensated hyperthyroidism; history of topical and aesthetic treatments in the last 3 months; glucose 6-phosphate deficiency; lack of ability or willingness to provide informed consent; lack of availability for visits or to comply with study procedures; hypersensitivity to ozone therapy treatment, climacteric or premature ovarian failure; pelvic pain complaints; use of oral or injectable hormonal contraceptives; progestogens	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-10b93fbz	Effectiveness of Percussive Massage using a portable device on muscle pain in amateur runners	Recruiting	Intervention	2023-06-28	<NULL>	<NULL>	6181	Effectiveness of Percussive Massage using a portable device on muscle pain in recreational runners: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10b93fbz	<NULL>	Age from 18 to 59 years; both sexes; running for at least two months; able to cover a distance of ten kilometers without interruption	Self-report of musculoskeletal pain at the time of data collection; difference greater than 1.5 cm in the size of lower limbs; not complete the established distance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-7xnnb4z	Effectiveness of periodontal treatments in obese and diabetic individuals	Not yet recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5201	Evaluation of different treatments for periodontal diseease in obese and diabetic individuals - Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Thayná Nathally Petry de Paula	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7xnnb4z	<NULL>	As inclusion criteria, patients will be of both sexes, with diabetes mellitus II (Glycated hemoglobin greather or equal to 7% at the last medical check-up) and stage II or III Grade C periodontitis; with at least 4 sites with probing depth above 5mm and level of clinical attachment greater than or equal to 4mm, not on the same tooth, with bleeding on probing and gingival inflammation, free of caries and/or prostheses on clinical examination; All patients must have at least 12 teeth present, excluding third molars and teeth suitable for extraction	As exclusion criteria, patients must present a positive history in the last six months of antibiotic therapy, steroid or non-steroidal anti-inflammatory drugs, anticoagulants and immunosuppressants in the three months preceding the study; positive history of pregnancy or breastfeeding; positive history of use of contraceptives or any other form of hormone; positive history of smoking or permanent cessation of the habit for at least 5 years; positive history of periodontal treatment in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-88shyrm	Effectiveness of phonation in tubes submerged in water performed via Telehealth and face-to-face: randomized blinded clinical trial	Recruitment completed	Intervention	2024-02-01	<NULL>	<NULL>	6767	Effectiveness of the Water Resistance Therapy Protocol performed via Telehealth and face-to-face: randomized blinded clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-14	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-88shyrm	<NULL>	Participants of both genders; aged between 18-50 years old; with moderate vocal deviation; with otorhinolaryngological diagnoses of behavioral dysphonia; and who have never go through vocal therapy or the period without vocal therapy is equal or superior to six months.	Participants who are smokers; pregnant; in menopause; had undergone surgery in the neck and larynx; presented signs of psychogenic dysphonia; and have any auditory impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-3cbjq9	Effectiveness of Photobiomodulation in Sensitivity to tooth Whitening in adults: randomized clinical trial.	Data analysis completed	Intervention	2020-09-10	<NULL>	<NULL>	4237	Laser therapy applied for Sensitivity after tooth Whitening	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-07	Universidade Federal do Amazonas - UFAM	Universidade Federal do Amazonas - UFAM	https://ensaiosclinicos.gov.br/rg/RBR-3cbjq9	<NULL>	At least canines with A2 or darker color and six superior anterior teeth free of restorations on the palatine and vestibular faces, healthy enamel and without pathological, physiological and drug alterations.	Volunteers with systemic diseases (metabolic, heart disease and immunological), oral condition with periodontal diseases. with orthodontic appliance, severe crowding, presence of intrinsic stains, using anti-inflammatory drugs, smokers, alcoholics, pregnant women or lactating women. Patients who reported strong or very strong sensitivity (scores from 3 to 4) of the 5-point Numerical Scale (NRS: 0 - no sensitivity, 1 - mild, 2 - moderate, 3 - strong and 4 - very strong) were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-964dgy	Effectiveness of physical activity counseling and referral schemes in the leisure time physical activity of an elderly cohort: a randomized controlled trial	Data analysis completed	Intervention	2015-09-30	<NULL>	<NULL>	624	Physical activity promotion programs for the elderly: from diagnosis to action - a proposal for the Primary Health Care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-09-20	Universidade Federal de São Paulo/Setor de Estudos do Envelhecimento	Universidade Federal de São Paulo/Setor de Estudos do Envelhecimento	https://ensaiosclinicos.gov.br/rg/RBR-964dgy	<NULL>	142 people aged over 60 who were part of EPIDOSO / UNIFESP Project were included; who answered the International Physical Activity Questionnaire - IPAQ at baseline (2008 and 2009) and had no impediments to regular physical activity.	Have not performed the evaluation with the International Physical Activity Questionnaire - IPAQ at baseline (2008 and 2009); have impediments to regular physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-9p3kmn8	Effectiveness of physical exercise in chronic respiratory disease	Not yet recruiting	Intervention	2021-01-22	<NULL>	<NULL>	4478	Effects of training in functional circuit on physical and functional aspects in elderly people with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-02	Universidade Federal do Parana	Universidade Federal do Parana	https://ensaiosclinicos.gov.br/rg/RBR-9p3kmn8	<NULL>	clinical diagnosis of COPD; clinically stable; without cognitive impairment; independent to perform instrumental activities of daily living; don&apos;t  use assistive devices for walking; with a medical indication for physical exercise	lung diseases such as asthma pulmonary fibrosis pneumonia and other non-pulmonary diseases such as heart disease or with sequelae of acute or chronic orthopedic and or neurological diseases that could influence the application of tests; patients who were inserted in a physical training program in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-3cbzwy	Effectiveness of Physical Measures versus Cabergoline for Lactation Inhibition	Not yet recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1768	The effect of Breast Binding with Bandages and Application of Ice Pack versus Cabergoline for lactation inhibition	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-15	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-3cbzwy	<NULL>	Women with up to 24 hours postpartum; gestational age at delivery of 20 weeks or more; indication for inhibition of lactation: late fetal loss, neomorto up to 24 hours, breast cancer or leukemia in pregnancy or in case of severe maternal morbidity	"Hypertensive syndromes in current gestation; known hypersensitivity to cabergoline; history of cardiac valve disease;
history of retroperitoneal or pulmonary fibrotic disease"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-8r5c2qv	Effectiveness of physiotherapist performance on the functionality of workers using computer terminals: randomized clinical trial	Recruitment completed	Intervention	2024-11-13	<NULL>	<NULL>	7512	Effectiveness of physiotherapeutic intervention on the functionality of workers using computer terminals: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-07	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8r5c2qv	<NULL>	Individuals aged 18 or over; who work at the State Secretariat for Administration using the computer; with a workload of more than 4 hours per day; who agree to participate in the research by signing the Informed Consent Form; and also participate in the physiotherapeutic intervention for three months, ensuring adherence to treatment	Participants who do not adhere to the proposed interventions, considering the maximum percentage of absences of 30% of the proposed physiotherapeutic intervention; those who are terminated, removed, go on vacation or leave, during the carrying out of this study and the worker who does not present medical certificate; workers who have a diagnosed serious illness;  who use medication regularly; are practicing other physical activity (gym, sports, dancing, running, walking, gymnastics) and/or carrying out physiotherapeutic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-2sgtn2	Effectiveness of Pilates and ingestion of Green Tea in elderly patients who have Metabolic Syndrome	Not yet recruiting	Intervention	2015-01-12	<NULL>	<NULL>	368	Effectiveness of the Pilates method and the supplementation with Green Tea (Camelia Sinensis) in the biochemical, oxidative markers, antioxidant status levels and in gene expression in elderly patients with Metabolic Syndrome - clinical trial randomized double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-07	Pontifícia Universidade Católica do Rio Grande do Sul	Programa de Pós-Graduação em Gerontologia Biomédica do Instituto de Geriatria e Gerontologia da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	https://ensaiosclinicos.gov.br/rg/RBR-2sgtn2	<NULL>	Aged over 60 years; female; have metabolic syndrome.	Have cardiovascular disease; have liver disease; gastric disease; thyroid problems; memory problems; anxiety and sleep disorders;have physical problems that preclude training with pilates;have done in the past or is doing pilates or other form of physical exercise on a regular way; intake green tea by regular or habitual way.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5w39snn	Effectiveness of Pilates exercises in the treatment of chronic low back pain	Data analysis completed	Intervention	2021-06-08	<NULL>	<NULL>	4734	Effectiveness of Pilates method in the treatment of nonspecific chronic low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Pontifícia Universidade Católica de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5w39snn	<NULL>	Individuals aged between 18 and 60 years who had NSCLBP lasting for more than 3 months.	Autoimmune rheumatic and inflammatory diseases, lower extremity radiating pain, fibromyalgia, thyroid disease, pregnancy, neurological or cognitive diseases, morbid obesity, lower limb amputees, patients with uncontrolled disease (e.g. hypertension or heart disease)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-4pphkf	Effectiveness of prayer in chronic kidney patients	Data analysis completed	Intervention	2020-06-30	<NULL>	<NULL>	3964	Effectiveness of prayer on chronic kidney disease patients on hemodialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4pphkf	<NULL>	Age over 18 years, literate, clinically stable and oriented about time and space when reaching 24 or more points in the Mini Mental State Exam.	Presence of deafness, as it was decided to apply the prayer with the aid of headphones; present limitations that compromised speech; and who have used anxiolytics within 24 hours prior to the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-6q23nk	Effectiveness of Proerd (Education Program on Drug and Violence Resistance)	Recruitment completed	Intervention	2019-05-06	<NULL>	<NULL>	2661	Effectiveness evaluation of the Education Program on Drug and Violence Resistance (PROERD) from de Militar Police of São Paulo State	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-25	Universidade Federal de São Paulo - UNIFESP	Polícia Militar de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6q23nk	<NULL>	No application of PROERD in the schools of São Paulo in the last 3 years	Non-student consent in completing the research instrument; application of the PROERD program in schools in the last 3 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-7g8p6s	Effectiveness of propolis in reducing the symptoms of rheumatic diseases in humans	Data analysis completed	Intervention	2016-10-19	<NULL>	<NULL>	1049	Propolis effectiveness of therapy in the treatment of signs and symptoms of rheumatism: Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-20	Pós Graduação em Ciências da Saúde	Pós Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7g8p6s	<NULL>	Inclusion criteria were the clinical diagnosis of tendinitis; bursitis or osteoarthritis and presence of pain resulting from rheumatic disease at the time of initial evaluation. Participants did not do any treatment for rheumatism two weeks before the start or during the clinical trial; or intra-articular corticosteroid injections in the previous three months.	We excluded patients with hypersensitivity to bee toxins, obesity, pregnancy and lactation, gastrointestinal bleeding history, gastric perforation; kidney disease, liver disease; current history of alcoholism, use of anticoagulants; implant prosthesis or pacemaker; severe chronic uncontrolled (hypertension, diabetes mellitus, heart disease and other diseases that by its nature or the proposed treatment could interfere with the assessment).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-3vmy6sq	Effectiveness of Routine Outcome Monitoring in Psychotherapy in the period of the COVID-19 pandemic	Data analysis completed	Intervention	2023-10-06	<NULL>	<NULL>	6487	Evaluation of the effectiveness of Psychotherapy in the period of the COVID-19 pandemic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	APHETO - Laboratório de Psicopatologia e Clínica Humanista Fenomenológica	Serviço de Psicologia Aplicada (SPA)	https://ensaiosclinicos.gov.br/rg/RBR-3vmy6sq	<NULL>	Persons over 18 years of age; Be registered with the Unified Health System (SUS); Be regulated in the SPA-NAMI system (study site); Present emotional distress in the COVID-19 pandemic period, through self-report in screening; Have availability for weekly psychotherapeutic care, with an average duration of 50 minutes, for six months remote or in person; Possess cognitive ability that allows the understanding and completion of the OQ®-45.2 and OQ®-ASC research instruments	Participants who were experiencing a severe emotional crisis related to a moderate or severe psychiatric disorder, which made systematic psychotherapeutic follow-up impossible; Patients who were already undergoing psychotherapeutic follow-up with another professional	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-39vm2nd	Effectiveness of screening actions based on Clinical Breast Examination in Breast Cancer stage and mortality: randomized study	Not yet recruiting	Intervention	2023-03-12	<NULL>	<NULL>	5944	Effectiveness of screening actions based on systematic Clinical Breast Examination in Breast Cancer stage and mortality: randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal de Goiás	Rede Brasileira de Pesquisa em Câncer de Mama	https://ensaiosclinicos.gov.br/rg/RBR-39vm2nd	<NULL>	Participating in the study will be women aged 40 years or older; living in the city of Itaberaí (urban and rural areas); users of the Unified Health System and registered by the Family Health Strategy; who accept to participate in the project and sign the Term of Free and Informed Consent	Women under 40 years of age; with a current or suspected diagnosis of breast cancer or who refuse to collect data or sign an informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-2ffwzb	Effectiveness of smoking cessation treatment	Recruiting	Intervention	2019-05-06	<NULL>	<NULL>	2657	Effectiveness of the Continued Approach to Cognitive Behavioral Therapy for Smoking Cessation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Escola Nacional de Saúde Pública Sérgio Arouca/Fundação Oswaldo Cruz	Escola Nacional de Saúde Pública Sérgio Arouca/Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-2ffwzb	<NULL>	The general selection criteria for inclusion of all the research participants will be: age greater than or equal to 18 years old; be a smoker; be a volunteer candidate to join the Smoking Control Program of the Centro de Saúde Escola Germano Sinval Faria.	Those younger than 18 years old; those who are not smokers; those who are not volunteer candidates to join the Smoking Control Program of the Centro de Saúde Escola Germano Sinval Faria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-5pn79s	Effectiveness of speech therapy for the elderly with vocal alterations	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2172	Effectiveness of a Speech-Language Therapy Program for Presbyphonia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-26	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5pn79s	<NULL>	Individuals of both sexes, with 60 years of age or older, diagnosed with presbylarynx, with no previous history of vocal fold lesions or who have undergone laryngeal fioricrosurgery and / or who have a previous diagnosis of pneumopathy, heart disease or neurological disease, or other laryngeal changes associated with presbylarynx.	Individuals who have undergone previous speech therapy, do not have adherence to the proposed speech-language therapy; smokers, singers, who have cognitive and neurological alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-2qv38rt	Effectiveness of Speech Therapy in the self-assessment of patients with Refractory Chronic Cough	Recruitment completed	Intervention	2025-07-30	<NULL>	<NULL>	8167	Effectiveness of Speech-language Pathology Rehabilitation in the self-assessment of patients with Refractory Chronic Cough	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2qv38rt	<NULL>	Individuals of both sexes; over 18 years of age; with a complaint of Refractory Chronic Cough for more than six months associated with underlying comorbidities who were in treatment for at least two months; using medications such as antibiotics, inhaled bronchodilators, inhaled steroids, oral corticosteroids, proton pump inhibitors, antihistamines; neuromodulators such as Morphine, Gabapentin and Pregabalin	Individuals with untreated comorbidities associated with Chronic Cough; those taking angiotensin-converting enzyme inhibitor medications; untreated infections in the last two months; individuals with lung conditions, such as lung cancer, lung metastases, previously diagnosed endobronchial lesions, and lesions resulting from thoracic radiotherapy; limiting neurological diseases; and smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-98xmss	Effectiveness of strategies in adherence to diagnostic method guidelines in cancer patients.	Not yet recruiting	Intervention	2018-11-19	<NULL>	<NULL>	2340	Effectiveness of implementation strategies in adherence to PET / CT guidelines in cancer patients.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-98xmss	<NULL>	Physicians specializing in oncology, hematology, proctology, thoracic surgery, pneumology, radiotherapy, pediatric oncology; To present care of SUS patients with a diagnosis of cancer with indication to PET/CT.	Not applicable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-59nbtf	Effectiveness of Supervised Physiotherapy in patients with Radius Fracture: Clinical study	Recruitment completed	Intervention	2020-03-17	<NULL>	<NULL>	6156	Effectiveness of Supervised Physiotherapy versus Home Exercise Program in patients with Distal Radius Fracture: A randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidad de las Americas	CDT Hospital San Borja de Arriaran	https://ensaiosclinicos.gov.br/rg/RBR-59nbtf	<NULL>	subjets aged 60 years or older; with medical diagnosis of extra-articular multifragmentary type FRD A3 after AO classification; with a conservative shape with a more simulated closed reducer; who accept and sign informed consent.	Subjects that present some immediate complication after the removal of immobilization as a painful regional type I complex;carpal tunnel syndrome etc; treated with some surgical intervention for the reduction and  or external fixation of radius fracture (flying plate, Kirschner needles); with some degree of cognitive impairment with a mini mental less than 26 points.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-4fcb4z4	Effectiveness of Tai Chi on patients with Chronic Neck Pain	Not yet recruiting	Intervention	2025-03-17	<NULL>	<NULL>	7842	Effectiveness of Tai Chi in patients with Nonspecific Chronic Neck Pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fcb4z4	<NULL>	Chronic nonspecific neck pain (defined as pain and discomfort) located in the neck region between the upper nuchal line and the scapular level for at least three months; age between 18 and 80 years; men and women may be included in the study; present pain intensity of at least three points on the numerical pain scale; reside in the region where the study will be conducted; the selected subjects will have to present sufficient knowledge of the Portuguese language to be able to answer the questionnaires	suspected or confirmed spinal diseases (e.g. tumor, infection, and fractures); history of spinal surgery; cardiovascular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-6xkzrfy	Effectiveness of tea made from Cissampelos sympodialis leaves in the treatment of anxiety and depression: a controlled clinical trial	Data analysis completed	Intervention	2023-08-22	<NULL>	<NULL>	6368	Infusion of the leaves of Cissampelos sympodialis Eichl. and auriculotherapy: modulation of anxiety and depressed mood	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-25	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-6xkzrfy	<NULL>	Adults aged at least 18 years old; physically and psychologically able to talk to the interviewers; intellectual and cognitive capacity to complete the questionnaires. They must attend the CRAS.	Pregnant women; nursing mothers; kidney disease patients; liver disease patients; use of psychotropic drugs; do not have the ability to understand and answer the questionnaires; sleeping during the intervention; refuse to receive the interventions; refuse to answer questions; refuse to sign the Term of Free and Clarified Consent (TCLE); Individuals whose external ear presents anatomical variations that make it difficult to locate the auricular points.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-9mtwh2j	Effectiveness of technologies in maintaining venous access in hospitalized children and adolescents	Not yet recruiting	Intervention	2024-07-19	<NULL>	<NULL>	7143	Effectiveness of technologies in the Maintenance of short Peripheral Intravenous Catheters in hospitalized children and adolescents (ManCIP)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-22	Universidade Estadual de Feira de Santana	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-9mtwh2j	<NULL>	Age between 1 and 14 years old. Intravenous therapy peripherally for 48 hours or more. Use of a Short Peripheral Intravenous Catheter for intermittent or continuous medication administration	Children who request to withdraw their consent or whose parents no longer consent to their participation during follow-up and children who remove the Short Peripheral Intravenous Catheter accidentally or on their own will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-78tr7x	Effectiveness of technology for nursing care	Not yet recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2093	Multimedia application to support the systematization of nursing care to the clinical patient	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade de Fortaleza	Laboratório de Tecnologia em Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-78tr7x	<NULL>	Students regularly enrolled in the year 2018; being in the discipline of caring 3 (Semiology)	Students who have previous experiences with anamnesis and physical examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-98v2y84	Effectiveness of technology&apos;s use for the management and control of type 2 Diabetes Mellitus. Study in a population residing in Complexo do Alemão, Rio de Janeiro	Data analysis completed	Intervention	2023-01-10	<NULL>	<NULL>	5810	Effectiveness of an Educational System and Remote Data Collection of patient information by Mobile Devices and the Internet in the metabolic control of type 2 Diabetes Mellitus A controlled study in a population residing in Complexo do Alemão, Rio de Janeiro	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-05	Hospital Universitário Pedro Ernesto	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-98v2y84	<NULL>	The study selected participants with a previous diagnosis of type 2 diabetes according to the American Diabetes Association criteria. Adults aged between 18 and 75 years; with a previous diagnosis of type 2 diabetes or fasting blood glucose &gt;126 mg/dL and/or random blood glucose &gt;200 mg/dL; under non-pharmacological treatment; oral antihyperglycemic agents or insulin use were included. All the participants received free internet access during the study. Thus, it was considered inclusion criteria to live in areas with available cabling for the establishment of an internet connection, which was provided by the study group	Patients with type 1 diabetes; other types of diabetes; and pregnant women were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-2yprts	Effectiveness of tele-rehabilitation compared to traditional physiotherapy in the treatment of stroke	Not yet recruiting	Intervention	2018-01-23	<NULL>	<NULL>	1589	Effectiveness of telereabilitation in the functional improvement, adherence and oxidative profile of people who had Stroke compared to usual care physical therapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal do Ceara	Universidade Federal de Goias	https://ensaiosclinicos.gov.br/rg/RBR-2yprts	<NULL>	volunteer with age of 18 years or more; presence of caregiver; and recent stroke defined as a diagnosis of stroke within four weeks.	Cognitive deficits established by the minimum score of 20, through the Montreal Cognitive Assessment (MoCA); cognitive assessment tool;  users who did not sign the Informed Consent Form (TCLE); excessive spasticity in the affected upper extremity defined by the score&gt; 3 by the Modified Ashworth Spasticity Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-5k95vs	Effectiveness of TENS associated with vocal therapy in women with vocal disorders	Not yet recruiting	Intervention	2020-05-20	<NULL>	<NULL>	3854	Effectiveness of the application of low-frequency transcutaneous electrical nerve stimulation associated with vocal therapy in dysphonic women: clinical trial, controlled, randomized and blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5k95vs	<NULL>	women aged between 18 and 50 years old; complaint of vocal alteration; altered voice evidenced by a speech-language auditory perceptual pre-assessment; bilateral vocal nodules or mucosal thickening or edema and glottic cleft on phonation; not having used TENS for any type of treatment	women who had received speech therapy before;  over 50 years of age; who reported being or had completed menstrual flow; who reported any general neurological alterations; thyroid gland changes, who had undergone clinical treatment for hormonal control (except contraceptive pill); vocal or surgical laryngeal treatment; heart problems, high blood pressure, hyper or hypothyroidism; smokers; alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-3z3qd6	Effectiveness of TENS in vocal therapy of women with vocal disorders	Data analysis completed	Intervention	2020-01-03	<NULL>	<NULL>	3326	The effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) in vocal therapy of dysphonic women: a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z3qd6	<NULL>	complaint of vocal alteration; altered voice evidenced by a speech-language auditory perceptual pre-assessment; bilateral vocal nodules or mucosal thickening or edema and glottic cleft on phonation; not having used TENS for any type of treatment	volunteers who had received speech therapy before;  over 45 years of age; who reported being or had completed menstrual flow; who reported any general neurological alterations; thyroid gland changes, who had undergone clinical treatment for hormonal control (except contraceptive pill); vocal or surgical laryngeal treatment; heart problems, high blood pressure, hyper or hypothyroidism; smokers; alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-6wrv5y	Effectiveness of the addition of pectoral stretching in patients with subacromial impingement syndrome: a clinical trial.	Data analysis completed	Intervention	2018-04-10	<NULL>	<NULL>	2461	Effectiveness of adding pectoralis minor stretches to an exercise program in patients with subacromial impingement syndrome: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	CDT Hospital San Borja de Arriaran	Universidad de las Americas	https://ensaiosclinicos.gov.br/rg/RBR-6wrv5y	<NULL>	Included:Patients over 18 years of age referred from the Adult Orthopedist Department with a clinical and imaging diagnosis of SIS type II; Who accepted and signed the informed consent.	Excluded;Patients who presented pathologies of cervical origin cervical such as radiculopathy; or other pathologies of the shoulder joint complex such as osteoarthritis in the acromioclavicular or glenohumeral joints, calcific tendinitis, adhesive capsulitis, glenohumeral instability; partial or full-thickness tear rotator cuff; etc;patients who have had history of acute trauma;previous surgery or previous fracture in the affected shoulder, patients who have had corticoid infiltration in the affected shoulder in the last 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-6gtj9k	Effectiveness of the bleaching technique delivered in custom-made or prefilled disposable trays	Recruitment completed	Intervention	2016-01-18	<NULL>	<NULL>	686	Effectiveness and clinical parameters evaluation of bleaching technique with 10% hydrogen peroxide dispensed in individual or pre-loaded trays	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	Centro de Pesquisas Odontológicas São Leopodo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6gtj9k	<NULL>	being aged between 18 and 30 years; presence of at least 20 sound teeth; presence of central and lateral incisors or upper and lower canines with at most 1/6 of the buccal surface restored.	teeth with an initial color of B1 assessed using a shade scale (Vitapan Classical, Vita, Germany) or spectrophotometer (VITA Easyshade® Advance, Vita, Germany); people wearing dentures or fixed/removable orthodontic appliances; pregnant or breastfeeding women; smokers; history of dentin sensitivity; presence of active caries in enamel or dentin; periodontal disease or other oral diseases; tetracycline-pigmented teeth; patients who had their teeth bleached before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-8yrrf9s	Effectiveness of the Fiocruz Vaccine ® against different variants of SARS-COV-2 in Botucatu-SP	Terminated	Observational	2021-06-30	<NULL>	<NULL>	5531	Study of the Effectiveness of the COVID-19 Recombinante/Fiocruz Vaccine ® against different variants of SARS-COV-2 in the municipality of Botucatu-SP	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-05-17	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; (UNESP) - Faculdade de Medicina de Botucatu (FMB)	Bill And Melinda Gates Foundation	https://ensaiosclinicos.gov.br/rg/RBR-8yrrf9s	<NULL>	"Residents of Botucatu aged between 18 and 65 years. This population is estimated to be 81.472 individuals.
Residents of Polo Cuesta aged between 18-65 years. 
Suspected to have SARS-CoV2 symptomatic infection and eligible as per case ascertainment guideline of the municipality for RT-PCR swab.
Informed consent prior to swabbing.
Children and adolescents (all non-vaccinated) from both communities will be included for the assessment of herd immunity. Informed consent of parents or guardians will be required."	Non-residents of Botucatu and healthy individuals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-3vzdfyz	Effectiveness of the mbrp ser online protocol in synchronous and asynchronous versions among university students	Not yet recruiting	Intervention	2026-01-23	<NULL>	<NULL>	8792	Effectiveness of the online synchronous and asynchronous versions of the MBRP Ser protocol among university students: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Be enrolled in an undergraduate or graduate program or be employed at one of the partner universities;  have agreed to participate in the study	Have a diagnosis of bipolar disorder; schizophrenia; another severe mental disorder; or a moderate to high risk of suicide; present acute symptoms of depression or anxiety without professional follow-up; have cognitive or sensory or motor impairments that may interfere with participation in the study; have previously engaged in mindfulness meditation within an 8-week structured protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-9ws5yfx	Effectiveness of the Mindfulness-based Health Promotion Program (MBHP) to improve the psychological well-being of university students: a study controlled and randomized	Recruitment completed	Intervention	2023-01-12	<NULL>	<NULL>	5817	Effectiveness of the Mindfulness-based Health Promotion Program (MBHP) to improve the psychological well-being of university students: a study controlled and randomized	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9ws5yfx	<NULL>	Healthy volunteers; undergraduate students at the Federal University of São Paulo (UNIFESP); campus São Paulo age greater than or equal to 16 years	Volunteers with acute mental disorders; age less than 16 years on the date of signature of the TCLE; previous pregnancy within six months or current; and regular practitioners of mindfulness, meditation, yoga	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-10kxn5rs	Effectiveness of the Pikluc® to relieve pain of intramuscular injection in children and adolescents	Not yet recruiting	Intervention	2023-07-03	<NULL>	<NULL>	6194	Effectiveness of the Pikluc® Device for pain relief associated with intramuscular injections in children and adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-10kxn5rs	<NULL>	Medical indication for intramuscular injection, in the right or left ventro-gluteal region or right or left deltoid region; to have the possibility of body weighing and height measurement; to be aged between 4 and 15 years; both genders	Cognitive deficit; psychiatric disorders; diseases that felt sensitivity to pain; having ingested substances that affect sensitivity to pain; people who underwent invasive procedures on the same day as the intramuscular injection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-7tyg5j	Effectiveness of the Pilates method performed in the equipament or in the mat	recruitment completed	Intervention	2012-02-13	<NULL>	<NULL>	106	Effectiveness of the Pilates method performed in the equipament or mat Pilates in the treatment of chronic non-specific low back pain.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-10	Universidade Cidade de São Paulo	CRISTINA MARIA NUNES CABRAL	https://ensaiosclinicos.gov.br/rg/RBR-7tyg5j	<NULL>	Patients with low back pain longer than three months, of both gender and aged between 18 and 60 years.	The following criteria will be considered as exclusion: participants involved with the Pilates method regularly, pregnancy, previous surgery of the spine and lower limbs, history of spinal fracture, inflammatory disorders, rheumatic and neurological disorders, systemic metabolic disease, herniated disk, tumor, infection, osteoporosis, structural deformity , serious nervous commitment, do not understand the writing and speaking of the Portuguese language and participants who underwent physical therapy for chronic low back pain in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-9j53g4r	Effectiveness of the vaccine that protects against four different types of the dengue virus (QdengA) in the Municipality of Rio de Janeiro	Recruiting	Observational	2024-08-26	<NULL>	<NULL>	7272	Effectiveness of the Attenuated Chimeric Tetravalent Dengue Vaccine (QDenga) in the Municipality of Rio de Janeiro	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-16	Secretaria Municipal de Saúde do Rio de Janeiro	Secretaria Municipal de Saúde do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9j53g4r	<NULL>	Individuals of both genders; aged 18 to 59 years; residing in the Administrative Region (RA) of Guaratiba in the Programatic area (AP) 5.2 of the city during the inclusion period; Who agree to participate in the research	Individuals with immunosuppression; pregnant or lactating individuals; participants who have received any blood product in the last 3 months or have had a hypersensitivity reaction to any component of the vaccine; participants who have previously received any dengue vaccine; individuals with an acute febrile illness, or those who have received another live virus vaccine in the last four weeks will have their inclusion postponed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-4752n8	Effectiveness of topical use of flouride and toothbrushing in the control of white spot carious lesions.	Data analysis completed	Intervention	2016-09-26	<NULL>	<NULL>	1021	Effect evaluation &quot;in vivo&quot; of the fluoride ion and toothbrushing on White spot enamel lesions.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-04-12	UFRN - Universidade Federal Do Rio Grande do Norte	UFRN - Universidade Federal Do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4752n8	<NULL>	Healthy volunteers; between 12 and 18 years old; who needed as part of the orthodontic treatment of extraction of the first two upper premolars and first two lower premolars; they were healthy and without damage to the labial surface; who were not participating in a preventive program involving the use of fluoride.	Volunteers who were not wearing orthodontic braces; Volunteers using fluoridated products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-38c5f2h	Effectiveness of using a Customizable Healing Device for dental Implants: a Clinical Trial	Data analysis completed	Intervention	2024-04-17	<NULL>	<NULL>	6947	Effectiveness of using a Customizable Healing Device for Immediate Implants in the posterior region: a Randomized Clinical Trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-05-14	Fundação Universidade de Passo Fundo	Fundação Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-38c5f2h	<NULL>	Being indicated and extraction of posterior teeth and installation of dental implants; participants agree and sign the consent form; being in satisfactory health conditions to undergo treatment	Participants do not agree or do not sign the consent form; not being in systemic health conditions to carry out the treatment; failure to meet technical conditions for immediate dental implant installation after extraction. Teeth with furcation lesion or loss of gingival papillae will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-8s8c8c	Effectiveness of using networks on reducing pain and improving sleep in premature	Recruitment completed	Intervention	2017-11-27	<NULL>	<NULL>	2188	Effectiveness Positioning Hammock on reducing pain and improving the state of sleep and wakefulness in newborn preterm infants: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8s8c8c	<NULL>	Newborns with a gestational age between twelve thirty-seven p.m. weeks; use of non- invasive mechanical ventilation; nasal oxygen catheter; without supplemental oxygen; clinically stable; be admitted to neonatal intensive care unit	Newborns with a gestational age of 37 weeks; clinically unstable; need for invasive mechanical ventilation; neurological or cardiac involvement; bad facial birth defects.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-6hjt5q	Effectiveness of using teleconsultation in discharge in referral hospital for patients with stable coronary disease	Recruiting	Intervention	2015-06-08	<NULL>	<NULL>	506	Evaluation of the effectiveness of the use of teleconsultation in qualifying the counter-referral between primary and tertiary care to patients with stable coronary artery disease: a randomized non-inferiority trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-08	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6hjt5q	<NULL>	Chronic stable coronary artery disease over a year; functional class I or II at the time of consultation; do not have hospitalization in the last year from cardiovascular disease	Unstable patients who require medication adjustments; Patients who are performing some diagnostic evaluation at query time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-5r5dhf	Effectiveness of virtual reality, augmented reality and neurofunctional physiotherapy in postural control and cognition of individuals with Parkinson disease	Recruiting	Intervention	2018-11-30	<NULL>	<NULL>	2353	Effectiveness of virtual and augmented reality versus neurofunctional physiotherapy in the treatment of motors and non motors symptoms in patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-5r5dhf	<NULL>	"Medical diagnosis of Parkinson&apos;s disease according to the criteria of the London Brain Bank (Hughes et al., 1992);
Individuals over 50 years of age;
Non-institutionalized;
Mini Mental Score that does not characterize cognitive deficit;
Hohen &amp; Yahr between 1.5 to 3.0;
Patients who accept to participate in the project and sign the informed consent form according to the criteria of the Research Ethics Committee of the State University of Londrina"	"Individuals who realize other therapeutic treatment other than medication, who has a change in medication during the course of the study or who have associated diseases, such as: other neurological diseases, severe heart diseases, amputations, cognitive or comprehension deficits;
Alteration in the stabilization of doses of antiparkinsonian during the course of the study or more than three faults in the therapies will be considered as loss. There will be replacement of the losses to avoid influencing the statistical power of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-57pgws	Effectiveness of water with ozone mouthrinse in plaque formation and gingival inflammation: a crossover randomized clinical trial	Recruitment completed	Intervention	2020-01-30	<NULL>	<NULL>	3430	Effectiveness of ozonated water mouthrinse in early plaque formation and gingival inflammation: a crossover randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-20	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-57pgws	<NULL>	Informed consent signed; age between 18 and 40 years old; do not smoke; good systemic health; availability of 21 days to participate in the two experimental periods and the washout between them; 20 natural teeth, including the anterior teeth (excluding third molars); do not have restorations on the incisors, canines and premolars; do not use fixed or mobile orthodontic appliances; do not present anatomical irregularities such as enamel cracks; do not present gingival recession; do not present gingivitis and/or periodontitis; not having used antibiotics or anti-inflammatories within 30 days prior to the beginning of the trial period; do not present allergy to the product used; not being pregnant or breastfeeding; do not present tumors in the oral cavity.	Serious adverse events related to intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-3qfbw73	Effectiveness, safety and tolerability of Passion Fruit Peel in the control of type 1 Diabetes Mellitus	Recruiting	Intervention	2023-02-02	<NULL>	<NULL>	6676	A phase II,randomized, double-blind, placebo-controlled clinical study to evaluate the effectiveness, safety and tolerability of the Extract of the Pericarp of Passiflora edulis in the glycemic control of type 1 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3qfbw73	<NULL>	Both sexes aged between 18 and 60 years; type 1 diabetes mellitus diagnosis at least two years ago; absence of C-peptide; glycated hemoglobin between 7% and 10%; patients without significant changes in insulin dose (&lt;10% of the number of daily units) in the last eight weeks; agreeing to participate in the trial by signing the informed consent form	Illiterate; pregnant or breastfeeding; inability to follow research protocol; hypothyroidism; hyperthyroidism; Alzheimer&apos;s; Parkinson&apos;s; Schizophrenia; renal insufficiency; anemia; obesity (BMI&gt; 30 kg /m2); hemoglobinopathy; acute liver disease; chronic liver disease; unit of alcohol per week: &gt; 21 men and &gt; 10 women; consumption of 1 or more cigarettes per day; phytotherapy; non-steroidal anti-inflammatory drugs, opiates and corticosteroids; juices or other foods based on passion fruit (P. edulis); food supplements containing passion fruit (P. edulis) in the composition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5gbhw5w	Effects and Implementation of the ACT Program in Ceará	Recruitment completed	Intervention	2023-07-26	<NULL>	<NULL>	6277	Intervention program based on scientific evidence with a focus on positive parenting and prevention of violence against children: implementation, development, and research	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-26	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Instituto para a Valorização da Educação e da Pesquisa no Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5gbhw5w	<NULL>	Parents or main caregivers with parental role of 0-to-6-years old children	Participants with impaired understanding of the assessment instructions, which makes data collection unfeasible; parents or main caregivers with children upper than 6 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-3dncdr5	Effects and safety of a Lung Expansion Therapy protocol in patients with artificial airway admitted to intensive care units: randomized clinical trial	Recruiting	Intervention	2024-04-22	<NULL>	<NULL>	6953	Efficacy and safety of a Lung Expansion Therapy protocol in tracheostomized patients undergoing spontaneous ventilation in the intensive care unit: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-10	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-3dncdr5	<NULL>	Tracheostomized patients undergoing spontaneous ventilation; age greater than or equal to 18 years; of both sexes; with Maximum inspiratory pressure (PImax) less than minus 30; with pathologies of different etiologies; with prolonged bed rest (more than 14 days); admitted to an intensive care unit	Patients who present progressive worsening of the clinical condition; shock; fracture in the chest region; pneumothorax; Immediate postoperative period of abdominal surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-2gh23p	Effects CrossFit training and cranberry supplementation on the immune system	Recruitment completed	Intervention	2019-04-18	<NULL>	<NULL>	2614	Effects of extreme conditioning program and supplementation of cranberry on immunomodulation: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2gh23p	<NULL>	Do not have any musculoskeletal, autoimmune, cardiac, pulmonary or hypersensitivity disorders; do not use medications or food supplements including substances with antioxidant function for at least 30 days and antibiotic at least six months prior to the study period; be enrolled in CrossFit Quest and regularly practice for at least three months.	Do not perform any of the blood collections; do not perform any of the physical performance assessments; present any injury or motor impairment to perform the training; any upper respiratory tract infection during the experiment; regularly consume any food supplement composed of vitamins, minerals or bioactive compounds; do not consume any of the cranberry or placebo doses; have known allergy or intolerance to cranberry products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-9frj8q	Effects evaluation of web-based tailored tool to prevent mistreatment among intimate partners	Not yet recruiting	Intervention	2019-09-20	<NULL>	<NULL>	2980	Usability and efficacy evaluation of a web-based tailored intervention to prevent dating violence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Departamento de Psicologia Clínica da Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9frj8q	<NULL>	It will be included youth aged 15 - 29 years old involved in a current affective-sexual relationship	"To have less than 15 years old and more than 29 years old;
Do not be involved in a current affective-sexual relationship during recruitment phase"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-28mjwb	Effects lasertherapy on physical exercise in elderly women.	Recruitment completed	Intervention	2015-03-11	<NULL>	<NULL>	418	Effects of low-level laser therapy on isokinetic muscle performance in elderly women.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-28mjwb	<NULL>	Females; age between 60 to 70 years old; full active range of motion and no pain in the hip, knee and ankle; body mass index between 18 to 27kg/cm ²,  taking into account height and weight; active or irregularly active, second International Physical Activity Questionnaire short version.	Pain in the spine or lower limbs;  history of trauma or previous surgery in the lower limbs or spine; history of muscle injury the femoral quadriceps, coxofemoral subluxation of the joint; osteoarthritis of the hip and or knee; rheumatic, degenerative or neurological diseases;  fibromyalgia; hypertension and uncontrolled diabetes mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-6f32c6x	Effects of  a Mindfulness-Based Cognitive Therapy and mood induction procedure on autobiographical memory of non clinical participants	Recruitment completed	Intervention	2023-05-18	<NULL>	<NULL>	6090	Mindfulness, mood and overgeneralization of autobiographic memories	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Instituto de Psicologia da Universidade de Brasília - UnB	Universidade de Brasília - UnB	https://ensaiosclinicos.gov.br/rg/RBR-6f32c6x	<NULL>	Adults without depression diagnose or neurological disorders; age between 18 and 50 years	Beck Depression Inventory (BDI-II) baseline score of 12 or higher; use of drugs that interfere with cognition; mental health diagnose	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-43byv6	Effects of  Electrostimulation at Skin Regions that Correspond to Acupunture Points on the Heart Rate Control of Healthy Subjects	Recruiting	Intervention	2017-09-15	<NULL>	<NULL>	1376	Effects of Transcutaneous Electrostimulation at Acupuncture Points on the Autonomic Balance of Healthy Subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal do Estado do Rio de Janeiro	Universidade Federal do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-43byv6	<NULL>	Individuals of both sexes, between the ages of 18 and 30, who declare themselves to be healthy (absence of known chronic or acute pathologies) will be considered for the study.	Age greater than 30 and younger than 18 years, pregnancy, presence of cardiac pacemaker or intermittent cardiodesfibrillator, auditory devices, skull trauma, brain injury, status epilepticus, tetanus, chronic liver disease, chronic kidney disease, patients in use Of Sulfonylurea or Glibenclamide, or who have already undergone previous cardiac surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-9nckrq	Effects of  physiotherapy assisted by virtual games in the recovery of daily activities and well-being of patients with kidney disease on hemodialysis	Recruitment completed	Intervention	2016-11-01	<NULL>	<NULL>	1063	Effects of  physiotherapy assisted by virtual reality in functionality and quality of life of patients with chronic renal failure in dialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-02	Universidade Federal de Sergipe	Clinica de Nefrologia de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9nckrq	<NULL>	Volunteer both genders; older than 18 years; sedentary; performing hemodialysis three times per week for at least three months; stable clinical condition in terms of no hospitalizations or cardiovascular events within the 3 months prior to screening; Systolic blood pressure (SBP) &lt;200 mmHg and diastolic blood pressure (DBP) &lt;110 mmHg at baseline.	Volunteers with diagnoses of pulmonary, neurological or psychiatric disorders; presence of unstable angina; recent myocardial infarction less than 6 months; symptomatic left ventricular fibrillation; decompensated heart failure; visual and / or hearing disorders; musculoskeletal limitations; hemiplegia or hemiparesis that compromise the ability to perform the exercises; hospitalization during the study period; neoplasms in current chemotherapy and / or radiotherapy; diagnosis of infection by the human immunodeficiency virus; scheduled kidney transplant or already carried out; volunteers who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-268hqh	Effects of  pulmonary re-expansion maneuver on patients receiving mechanical ventilation	data analysis completed	Intervention	2012-05-01	<NULL>	<NULL>	135	Effects of Manual Chest Compression and Descompression Maneuver on Lung Volumes, Capnography and Pulse Oximetry in Patients Receiving Mechanical Ventilation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-21	Hospital e Maternidade Celso Pierro	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-268hqh	<NULL>	"Age greater than 18 years
Patients on mechanical ventilation
Ramsay sedation scale between 4 and 6 levels
Hemodynamic stability 
No osteoarticular lesions (rib fractures or unstable thorax)."	"Intracranial hypertension &gt; 30 mmHg
Pneumothorax 
Hemodynamic instability with use of high doses of vasoactive drugs, dopamine and dobutamine &gt; 5 µg/kg/min and noradrenalin &gt; 0.5 µg /kg/min"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7p23c3	Effects of  Strength Training on women with Polycystic Ovary Syndrome	Recruitment completed	Intervention	2014-11-10	<NULL>	<NULL>	449	Effect of resistance physical training periodization  on women with Hyperandrogenic Anovulation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7p23c3	<NULL>	"Age between 18 to 37 years; 
Body Mass Index between 18 and 39.9 kg/m2 (normal overweight and obesity grades I and II);do not practice regular physical activity."	Presence of systemic disease that indicate against the practice of physical activity; presence of disabling musculoskeletal disorders; use of drugs that interfere with the hypothalamic-pituitary ovarian axis and hormonal contraceptives; smoking; pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5ftj2fy	Effects of  Supplementation with Acid Gamma-aminobutyric associated with physical exercises at home for elderly	Recruitment completed	Intervention	2023-08-25	<NULL>	<NULL>	6388	Effects of Gamma-aminobutyric acid Supplementation combined with Physical exercises at Home on skeletal muscle mass in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-11	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-5ftj2fy	<NULL>	60 years or older; residents in the cities of Mariana and/or Ouro Preto; present at least pre-sarcopenia level; are vaccinated against Covid-19; commit to receiving the physical education professional assigned to do the training in their homes; maintain a regular frequency of at least 80% of training sessions	Not being in the situation described in the inclusion criteria; refuse to sign the TCLE; not completely responding to the research instrument; not showing interest in participating in the intervention; have any food allergies to GABA supplementation; food allergy to rice germ and gelatin; present severe cardiovascular alterations; present severe renal alterations; have dementia; present Parkinson&apos;s disease; present severe neuropsychological alterations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-7by76r	Effects of &quot; Anti-stress Therapy&quot; on behavior and stress hormones in infertile women and also on weight loss after diet and exercise guidance in those overweight	Data analysis completed	Intervention	2016-04-25	<NULL>	<NULL>	3472	Effects of &quot; Mind Body Therapy&quot; on behavioral and neuroendocrine markers of stress in infertile women and also on reducing the body mass index after diet and exercise guidance in those with overweight and obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-02	Hospital das Clínicas da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7by76r	<NULL>	Infertility; policystic ovarian syndrome; uterus, tube and/or ovarian disfuctions; overweight; obesity.	Refuse to sign the Informed Consent; give up the project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-9n4sn5m	Effects of 12-hour overnight fasting on metabolism and quality of life in overweight middle-aged women	Data analysis completed	Intervention	2023-01-05	<NULL>	<NULL>	5801	Metabolic responses of overweight/obesity climacteric women according to feeding times	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE	Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-9n4sn5m	<NULL>	Female individuals; aged between 40 and 59 years; body mass index (BMI) between 25 kg/m2 and 39.9 kg/m2; waist circumference above 88 centimeters	Women with previous diagnosis of changes in the thyroid gland; impaired liver function; impaired kidney function; cardiovascular diseases; cancer; serious illness; using medication that alters weight; diagnosed with psychiatric illnesses. In addition, they will also be deleted; gastrointestinal problems; using drugs that may interfere with body composition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-4m3mx7	Effects of 940 nm laser application on the control of mouth opening difficulty, swelling, pain and sensitivity after jaw surgery.	Recruiting	Intervention	2020-01-10	<NULL>	<NULL>	3351	Effects of 940 nm laser photobiomodulation therapy on the control of trismus, edema, pain and paraesthesia after orthognathic surgery. Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Odontologia da Universidade de São Paulo	Hospital Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4m3mx7	<NULL>	Individuals indicated to undergo bimaxillary orthognathic surgery with genioplasty; removal of third molars at least 6 months before surgery; regardless of gender and race; age group above 18 years; Signature of the Informed Consent Form (ICF).	Individuals submitted to monomaxillary surgery will be excluded; patients under 18 years of age; individuals with temporomandibular joint dysfunction; rupture of the inferior alveolar nerve during the surgical procedure; undesirable fractures; mandibular surgery with execution time above 2:30 h; deficient mandibular fixation; allergy to standardized anti-inflammatory drugs; postoperative infection; individuals who did not cooperate with PBMT therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-4pp65c6	Effects of a bodybuilding protocol with a minimum training dose in 8 weeks on the symptoms of Premenstrual Syndrome and the coping strategies of university students	Recruitment completed	Intervention	2025-02-12	<NULL>	<NULL>	7740	Effects of an 8-week minimal dose protocol on psychocogical symptoms of Premenstrual Syndrome (PMS) and the coping strategies of college students	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-21	Universidade Federal do Pará	Programa de Pós Graduação em Ciências do Movimento Humano	https://ensaiosclinicos.gov.br/rg/RBR-4pp65c6	<NULL>	Be woman; university student enrolled in a higher education institution; be between 18 and 50 years of age; have regular menstrual cycles; not be pregnant; not making use of medication for psychological control; does not have pathologies in the reproductive system; does not have musculoskeletal diseases; being sedentary; Premenstrual Syndrome carrier	Do not completely fill out any of the questionnaires given before and during the protocol; absence from training sessions; present pregnancy during the protocol; stop answering the questionnaire, practice other exercises during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-6rxswyt	Effects of a booklet on the knowledge, attitude and practice of caregivers of bedridden children and adolescents at home	Recruiting	Intervention	2024-03-05	<NULL>	<NULL>	6831	Effects of educational technology on the knowledge, attitude and practice of caregivers of beed-bed children and adolescents at home: an almost experimental study	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Universidade Estadual do Ceará	Hospital Infantil Albert Sabin	https://ensaiosclinicos.gov.br/rg/RBR-6rxswyt	<NULL>	Main caregiver of the child/adolescent aged 18 or over; know how to read and write	Caregivers who stopped caring for the child/adolescent during the data collection phase; caregivers of children/adolescents who die during the data collection phase; caregivers of children/adolescents who required hospitalization at some stage of the research and caregivers who withdrew from participating in the study at some stage of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-8c5cjmg	Effects of a Brain Reprocessing Psychotherapy in treating Obesity in adolescents: a quali-quantitative approach	Data analysis completed	Intervention	2022-08-03	<NULL>	<NULL>	7174	Effects of Brainspotting in treating Obesity in adolescents: a quali-quantitative approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8c5cjmg	<NULL>	Adolescents with exogenous obesity; Body Mass Index (BMI) z score &gt;2; both genders; aged between 10 and 19 years old; followed up by obesity ambulatory at Nutrology Discipline of São Paulo Federal University’s pediatrich department	Adolescents with pathology that causes difficulties of comprehension, difficulties of reasoning and cognitive deficit; cardiac, neurologichal and psychiatric patologies diagnosis in wich is not recommended the intervation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-3t85fd	Effects of a care program for risk factors for falls in a prevention program for elderly people who fall: a randomized clinical trial	Recruiting	Intervention	2020-09-25	<NULL>	<NULL>	5846	Effects of a Case Management Program based on fall Prevention in elderly people who fall: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-20	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3t85fd	<NULL>	Age 60 or older up to 95; living in Brazil; not institutionalized; history of at least two falls in the last 12 months; ability to walk alone with or without gait assistance; availability to participate in the evaluations and interventions; with access and familiarity with virtual communication with audio and camera; or that has a relative or caregiver with access and familiarity with virtual communication with audio and camera; familiarity with virtual communication with audio and camera	Involvement in regular and systematized physical activity with a total duration of 150 minutes per week; severe and uncorrected hearing or visual disorder that makes communication difficult during the assessment and intervention; motor sequelae of stroke; active inflammatory diseases and neurological diseases that interfere with the risk of falls; such as advanced Parkinson&apos;s disease (stage 5 of the modified Hoehn and Yahr Scale and not being in regular use of antiparkinsonian medications); Multiple Sclerosis; Huntington&apos;s disease; dementia; uncontrolled vestibulopathy; epilepsy; and traumatic brain injury; taking associated medications that indicate the presence of these diseases; absence or instability of internet for the proper conduct of the evaluations and follow-up of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-6z8qqy	Effects of a Cereal Bar source of vegetable Estrogen on the symptoms of Menopausal women	Recruitment completed	Intervention	2020-04-17	<NULL>	<NULL>	3751	Development of a Cereal Bar source of Phytoestrogen and effects on the syntomatology of Climate women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-25	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-6z8qqy	<NULL>	Climacteric women with symptoms assessed using the Kupperman Index.	Use of hormone replacement therapy; consumption of supplements with some type of phytoestrogen; consumption of hypolipidemic or hypoglycemic agents; frequent consumption of alcoholic beverages; smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-4xhrsy	Effects of a combined exercise program during hemodialysis treatment in patients with Chronic Kidney Disease	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	2747	Effects of an aerobic exercise program during intradialytic treatment in patients with chronic kidney disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-05	Universidade Federal do Rio Grande do Sul - UFRGS	Hospital de Clínicas de Porto Alegre - HCPA / UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-4xhrsy	<NULL>	"Diagnosis of Chronic Kidney Disease more than six months.
Patients in hemodialysis for at least 3 months.
Patients in hemodialysis at the Nephrology Department of the Hospital de Clinicas de Porto Alegre or in the Instituto de Doenças Renais
Older than 18 years.
Sedentary.
Physical condition to perform exercises and tests proposed in this study.
Stability of the chronic kidney disease more than 30 days."	"Patients who do not perform all stages of the study.
Presence of acute myocardial infarction in the last 3 months.
An active inflammatory or infectious process.
Decompensated coronary artery disease.
Implantable kidney transplant candidate with live donor expected to undergo transplantation in the next 4 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-3r3mqw	Effects of a containing ora-pro-nobis product on the gut and anthropometric data in adults	Data analysis completed	Intervention	2019-10-03	<NULL>	<NULL>	3028	Development of containing Ora-Pro-Nobis (Pereskia aculeata Mill.) Product and its influence on intestinal microbiota, antioxidant capacity, anti-inflammatory, biochemical and anthropometric parameters in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3r3mqw	<NULL>	Women, aged between 20 and 60 years. Fat percentage above 25%. Not having participated in weight loss program in the last six months; Be healthy.	"Have a diagnosis of autoimmune, endocrine, cardiac, cerebrovascular, renal, hepatic, gout, gastrointestinal, inflammatory and / or infectious diseases;
have made use of dietary supplements, laxatives and antibiotics in the last six months;
have undergone surgery in the last six months;
have made regular use of alcohol, cigarettes and other drugs in the last year;
be vegetarian;
being on herbal remedies or preparations;
exhibit allergic reactions to product components;
be pregnant or nursing;
have ingested probiotic in the last year."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-9kfnshy	Effects of a Conventional Cardiovascular Rehabilitation protocol compared to the use of Game therapy in participants with type 2 Diabetes	Not yet recruiting	Intervention	2025-08-28	<NULL>	<NULL>	8238	Effects of a Conventional Cardiovascular Rehabilitation protocol versus adapted to Virtual Reality in participants with type 2 Diabetes: Controlled and randomized study protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9kfnshy	<NULL>	Individuals age eighteen and over; both genders; without Pulmonary diseases and Peripheral arterial obstructive disease; those who undergo regular monitoring by an angiologist and endocrinologist; residents in the city of Natal / RN; who are not enrolled or have participated in the last six months prior to the study in any Cardiovascular rehabilitation program	Individuals with acute or uncontrolled Congestive heart failure; individuals with unstable or uncontrolled Angina; individuals with uncontrolled Cardiac arrhythmia causing hemodynamic symptoms; subjects with severe symptomatic Aortic stenosis; individuals with Deep venous thrombosis; individuals with recent Pulmonary embolism; individuals with Pericarditis or Acute myocarditis; individuals with Dissected aneurysms (known or suspected); individuals with unstable or uncontrolled Blood pressure (systolic pressure greater than one hundred sixty millimeters of mercury and diastolic pressure greater than one hundred millimeters of mercury); individuals with Acute systemic infection or uncontrolled Diabetes; individuals with limitations due to Musculoskeletal diseases or Cognitive difficulty in understanding activities; individuals who present Sweating and/or Dizziness during the evaluation and/or exercise Protocol, peripheral oxygen desaturation during the Step test below ninety percent; individuals who drop out or miss two consecutive Training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-34d7jm	Effects of a dance program in motor and non motor symptoms of patients with Parkinson&apos;s disease.	Recruitment completed	Intervention	2017-01-17	<NULL>	<NULL>	1160	Effects of a systemized dance program in motor and non motor aspects of patients with Parkinson&apos;s disease: a randomized controlled study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-34d7jm	<NULL>	Patients between stages 1 to 3 of the Hoehn &amp; Yahr scale; in regular use of specific medication for Parkinson&apos;s disease.	Cognitive deficits that could affect the understanding of the evaluation protocol and tasks proposed in the intervention groups; auditive and visual problems not corrected; other neurological diseases and musculoskeletal problems that affect the participation in the proposed intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-9nf6d27	Effects of a digital health education on the knowledge of patients with low back pain about the condition	Not yet recruiting	Intervention	2024-03-04	<NULL>	<NULL>	6825	Effects of an online intervention in patients with low back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-15	Universidade do Oeste Paulista - UNOESTE	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9nf6d27	<NULL>	Adults (over eighteen years old); report low back pain without any restriction for duration of symptoms	People unable to understand the Portuguese language; healthcare professionals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-5yjyr7	Effects of a dual-task aquatic and terrestrial physical exercise program on motor and cognitive functions of individuals with Parkinson&apos;s Disease - AquaDualPark study	Data analysis completed	Intervention	2020-09-11	<NULL>	<NULL>	4239	Parkinson&apos;s Disease and Physiotherapy: Analysis of the impact of intervention programs with terrestrial and aquatic physical activities - FisioPark	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Paraná	Prefeitura Municipal de Curitiba - Secretaria da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-5yjyr7	<NULL>	Diagnosis of idiopathic Parkinson&apos;s disease; Be between stages 2 to 4 of the Hoehn &amp; Yahr scale; Agree to the Free and Informed Consent Form; Present medical certificate clearing to practice physical activity; Present medical certificate clearing to practice aquatic physical activity; Present independent march; Present visual, auditory and cognitive skills to follow verbal instructions during evaluations and interventions	Present changes in the dosage of Levodopa or other Parkinson-related medication during the research; Do not agree with the Informed Consent Form; Do not present a medical certificate clearing to participate in physical activity or for aquatic activity; Present physical or cognitive changes that prevent participation in evaluations and interventions; Do not carry out initial, intermediate and / or final evaluations; Present more than 75% of absences in the intervention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-2fxn942	Effects of a dynamic school environment on cognitive function, academic performance, and health in youth	Recruitment completed	Intervention	2025-11-08	<NULL>	<NULL>	8488	Effects of School Environment Dynamization on Cognitive Function, Academic Performance, and Health Indicators in Youth: A Multicenter Cluster-Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-02	Departamento de Educação Física - Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Students in the 2nd year of elementary school from municipal schools in Aracaju/SE, Arapiraca/AL, Feira de Santana/BA, and Ilhéus/BA; aged between 7 and 9 years; must not present any impediment to performing postural transitions; must return the duly signed informed consent form from parents or guardians.	Students who stop attending school for any reason or express interest in leaving their studies will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:03
RBR-5n7k99	Effects of a flichart on breastfeeding and exclusive breastfeeding	Recruitment completed	Intervention	2016-06-03	<NULL>	<NULL>	882	Effects of an Educational Technology in self-Efficacy to Breastfeed and Practice of exclusive breastfeeding	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-12-07	Universidade Federal de Pernambuco	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5n7k99	<NULL>	Pregnant during third trimester; breastfeeding plans; literate; have telephone or cellphone	women with multiple gestations; clinical limitation to breastfeed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-2vmpz9	Effects of a Formulated Drink on post exercise Recovery	Recruitment completed	Intervention	2019-12-10	<NULL>	<NULL>	3271	Effects of a Formulated Drink on post exercise Recovery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2vmpz9	<NULL>	Healthy volunteers; College students; male; age between 18 and 30 years; regular frequency of soccer practice at least twice a week.	Volunteers who took drugs, smokers, who used dietary supplements (multivitamins or protein supplements) in the last three months; milk allergy; were injured and / or ill in the last month prior to the start of the study; those who expressed interest in abandoning the study or presenting a factor such as injury and / or need for drug treatment during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-9gffcgq	Effects of a goal-oriented collaborative intervention associated with home positioning strategies for non-ambulatory children with cerebral palsy	Not yet recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6342	Effects of a goal-directed collaborative intervention with postural management strategies by telehealth in children with non-ambulant Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9gffcgq	<NULL>	Children aged 1-5 years with a diagnosis of cerebral palsy (CP) VERIFICAR SIGLAS , classified at levels IV and V of the Gross Motor Function Classification System (GMFCS), who receive conventional Physical Therapy 1 or 2 times a week, in the state of Minas Gerais, Brazil.	Children with clinical instability, tracheostomy or oxygen dependents; or those who had undergone surgery or botulinum toxin injections in the last six months. Those who are currently participating in an intensive physiotherapy protocol will only be included when the protocol ends and three months after they return to the Conventional Physical Therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-4yjvpxg	Effects of a Group Intervention to prevent Post-traumatic stress disorder linked to childbirth: a comparative study between two groups of high-risk pregnant women	Not yet recruiting	Intervention	2022-05-23	<NULL>	<NULL>	5401	Evaluating the effectiveness of a Brief Intervention for Post-traumatic stress disorder associated with childbirth/birth: a clinical, randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-04	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4yjvpxg	<NULL>	The pregnant women must be 18 years of age or older; being in the third trimester of pregnancy (between 28 and 32 weeks of gestation); no history of previous (self-reported) mental disorders, except for common mental disorders and current ones (score on the Self Report Questionnaire less than 7), score on the Health Questionnaire of the Patient-9 less than 10 and General Anxiety Disorder Questionnaire-7 score less than 10; not being in psychological and psychiatric treatment at the time of data collection; and agree to voluntary participation in the study, signing the Free and Informed Consent Form	Women who drop out of the study at any stage of data collection before the conclusion of the same; do not attend the sessions for the application of the assessment instruments or the meetings of the intervention group, regardless of the reason; and are not found after the pregnancy is resolved by the telephone and/or e-mail provided by them for the evaluation of outcomes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-5tdnbr	Effects of a health education program for patients with fibromyalgia	Data analysis completed	Intervention	2014-05-29	<NULL>	<NULL>	299	The impact of a health education program on neuroimmune and behavioral aspects of fibromyalgia patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-11-01	Universidade Federal de Minas Gerais - UFMG	Centro Universitário de Formiga - MG (UNIFOR-MG)	https://ensaiosclinicos.gov.br/rg/RBR-5tdnbr	<NULL>	Female gender; aged between 18 and 60 years; fibromyalgia diagnosis confirmed by a medical specialist	Less than 18 years, over 60 years old; modification in the pharmacologic treatment in the last three months; chronic inflammatory condition associated; autoimmune disease associated; history or presence of psychiatric disorders, infectious diseases, use of anti-inflammatory, antiallergic or antibiotic drugs in the last three months, pregnant women, lactating, participation in lower 80% of the classes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-10jjpqy4	Effects of a Health Lecture Program compared with Exercise Classes plus Lectures, delivered through a website, on pain self-efficacy of people with Patellofemoral pain: randomized clinical trial	Recruitment completed	Intervention	2023-05-17	<NULL>	<NULL>	6087	Effects of an Education Program compared to Exercise associated with Education, delivered through an Online Platform, on pain self-efficacy in patients with Patellofemoral pain: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-06	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-10jjpqy4	<NULL>	Age between 18 and 40 years; both genders; unilateral anterior knee pain when performing at least two of the following activities: remaining seated for a prolonged period, squatting, kneeling, running, climbing and descending stairs, jumping and landing; anterior knee pain of insidious onset lasting at least 6 months; worst self-reported pain in the last month of at least 30mm on the 100mm Visual Analogue Scale (VAS)	Self-reported anterior knee pain caused by knee trauma; self-reported history of patellar dislocation or subluxation, meniscal injury, ligament instability, patellar tendinopathy or osteoarthritis in any lower limb joint; having undergone prior physical therapy for the treatment of patellofemoral pain (at least 6 months prior to the study); answer yes to one or more questions on the PAR-Q physical activity readiness questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-9tmdkh4	Effects of a heart training protocol associated with LED light therapy on signs and symptoms, performance and functionality of people with diabetes and nerve involvement	Recruiting	Intervention	2024-11-11	<NULL>	<NULL>	7497	Effects of a Cardiovascular Rehabilitation Protocol associated with Photobiomodulation on signs and symptoms, performance and functionality of individuals with Diabetic Neuropathy – a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-05	Departamento de Fisioterapia - Universidade Federal do Ceará	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-9tmdkh4	<NULL>	Individuals aged 18 years or older; both sexes; who have a diagnosis of Diabetes Mellitus (type 1 or type 2) confirmed by a doctor (fasting plasma glucose higher or equal 126mg/dl and/or glycated hemoglobin higher or equal 6.5%); presence of diabetic peripheral neuropathy confirmed in the evaluation	Individuals with neuropathy of other etiologies; severe chronic kidney disease; severe diabetic retinopathy; presence of unhealed ulcers in the lower limbs; pregnant women or those intending to become pregnant; and individuals with contraindications for performing physical exercises or with performance limitations that make it impossible to conduct the assessment and training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-3pz4dh	Effects of a home exercise program of strength and cardiopulmonary resistivity in patients with Chronic Renal Disease	Not yet recruiting	Intervention	2019-01-18	<NULL>	<NULL>	2448	Effects of a household program of exercises in patients with Chronic Renal Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-04	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3pz4dh	<NULL>	"Diagnosis of kidney disease for more than 6 months.
Patients undergoing hemodialysis at the HCPA Nephrology Service for at least 3
months.
Age equal or superior to 18 years.
Physical conditions to perform exercises and the tests proposed in this study.
CKD stability for at least 30 days, defined by the absence of
hospitalization and / or modification of the usual therapeutic regimen."	"Presence of acute myocardial infarction in the last 3 months.
Presence of pacemakers and defibrillators making it impossible to perform the
Bioimpedance.
Active inflammatory or infectious process, evidenced by leukogram outside the
limits of normality.
Decompensated coronary artery disease.
Peripheral arterial disease.
Implantable kidney transplant candidate with live or predicted donor
transplant in the next 3 months.
Cognitive, auditory and visual changes that limit the understanding of
evaluations and interventions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-3cqzfy	Effects of a Home Physical Exercise Program, with Monitoring every 15 Days, on Sleep Quality of the Elderly: a Randomized Clinical Trial	Recruiting	Intervention	2016-12-12	<NULL>	<NULL>	1354	Effects of a Non-Supervised and Guided Home Physical Exercise Program on Elderly Sleep Quality: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-3cqzfy	<NULL>	Resides in the urban area of the municipality of Senhor do Bonfim-Ba, is 60 years of age or older, has not exercised regularly for at least three months prior to the study, score less than or equal to 5 on the Pittsburgh Sleep Quality Index (PSQI-BR).	Participants with cognitive decline according to the Mental State Mini-Exam will be excluded from the study, they will be performing some treatment for sleep disorder (including the use of sleeping pills more than once a week) and present any Clinical condition that contraindicates the performance of physical activity, identified through a medical and physiotherapeutic evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-59xgczn	Effects of a home-based exercise preparation program on the physical and emotional health of people with Obesity waiting for stomach reduction surgery	Not yet recruiting	Intervention	2026-03-03	<NULL>	<NULL>	8932	Effects of a home-based prehabilitation program on the physical and psychological aspects of individuals with Obesity waiting for metabolic and bariatric surgery	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade do Estado de Santa Catarina - UDESC	<NULL>	<NULL>	<NULL>	People of both sexes; 18 years of age or older; with grade III (severe) obesity; body mass index (BMI) &gt; 40 kg/m2; indication for bariatric surgery; formal indication for preoperative physiotherapy; absence of comorbidities that compromise the safety or ability to perform physical and functional tests applied in the study (e.g., six-minute walk test, 5-repetition chair stand-up test)	History of previous bariatric surgery; previous clinical diagnosis of acute or chronic respiratory diseases that may compromise the safety of physical tests (e.g., COPD, asthma with remodeling); abdominal or thoracic surgeries performed in the last year; pacemaker use; history of myocardial infarction in the last three months or unstable angina pectoris; sustained or episodic cardiac arrhythmias that may be aggravated by physical activity; symptomatic peripheral vascular disease; any other clinical condition that, at the discretion of the responsible investigator, represents a risk or impossibility of participation in the study; abuse of or chemical dependence on psychoactive substances (including alcohol and illicit drugs), according to clinical criteria and/or previous diagnosis; cognitive and physical alterations that prevent the performance of the tests	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-10z9pgfv	Effects of a home-based motor care program with remote and presential monitoring in individuals with Amyotrophic Lateral Sclerosis: randomized clinical trial	Recruiting	Intervention	2021-02-05	<NULL>	<NULL>	5288	Effects of an optimized respiratory and motor care protocol in patients with Amyotrophic Lateral Sclerosis: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-25	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-10z9pgfv	<NULL>	This study will include definite, probable, or possible participants with ALS of both sexes, diagnosed by a neurologist, according to the criteria of El Escorial criteria, aged between 18 and 80 years, and able to understand and perform simple motor instructions according to verbal commands	Bedridden participants under continuous use of non-invasive ventilation and those who need but do not have caregivers available will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-43x6kh	Effects of a intensive therapy for the legs on the way of walking and balance for people who suffered stroke.	Recruiting	Intervention	2018-10-04	<NULL>	<NULL>	2264	Effects of Contraint Induced Movement Therapy for lower extremities on gait and balance functionality in post-stroke patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-30	Associação de Assistência a Criança Deficiente	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-43x6kh	<NULL>	"Medical diagnosis of stroke (ischemic or hemorrhagic), with only one event, and have suffered stroke for 6 months or more at the beginning of the protocol; Clinically stable;
- Hemiparesis caused by stroke; Defict of gait caused by stroke; Hip and knee flexion intiation on the affected side; Move from sit to stand independently even with the aid of upper limbs and/or auxiliary device and/or furniture; Be able to transfer in an independent way when seated; Be able to sustain the body weight on the affected side even requiring aid from a third person, auxiliary device or furniture; Be able to walk 10 meters with or without requiring aid from a third person, auxiliary device or furniture;  Have always the same caregiver (we will accept at most 2); Be available for going to the rehabilitation center during 17 followed days (15 days for treatment, and 2 days for evaluation); Not have undergone orthopedic surgery in the last 6 months, or neuromuscular blockade in the last 3 months; Not be able to walk outside of home in an independent way."	Not accept the protocol to which was allocated by randomization; Language change that will not allow the participant to understand, as well as respond appropriately to the proposed assessment scales and exercises selected for the protocol; Clinical intercurrence between the screening and the beginning of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-38gw93c	Effects of a maintenance program with different supervision frequencies in individuals with chronic respiratory disease	Recruiting	Intervention	2025-06-26	<NULL>	<NULL>	8070	Effects of a physical exercise maintenance program with different supervision frequencies in individuals with COPD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-13	Universidade Federal de São Carlos	Departamento de Fisioterapia da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-38gw93c	<NULL>	Participants diagnosed with Chronic Obstructive Pulmonary Disease (COPD); who have completed, within the past month, a 12-week physical training program involving resistance and aerobic exercise, with or without behavioral change strategies; aged 50 years or older; of both sexes; who have been clinically stable for the past four weeks; undergoing medical follow-up with pharmacological treatment; who agree to participate in the study and have signed the informed consent form	Participants undergoing treatment for malignant neoplasms; with rheumatic, neuromuscular, orthopedic, or visual disorders that prevent physical training; with decompensated cardiovascular or respiratory diseases that hinder the performance of tests; and participants who choose to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-56yk9m	Effects of a manual therapy technique on the stress of workers in the garment industry	Recruitment completed	Intervention	2019-06-27	<NULL>	<NULL>	2791	Acute effects of limbic touch on stress experienced by workers in the garment industry	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-07	Centro Universitário de Formiga	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-56yk9m	<NULL>	The inclusion criteria were confection workers of the city of Candeias female aged between 20 and 50 years of any educational level with a daily workload of eight hours who agreed to participate voluntarily in the research and who have not used any type of medication in the last month except contraception.	The criteria for non-inclusion were confection workers who were pregnant or breastfeeding who were using or who used any non-contraceptive medication in the last month who did not achieve a minimum score of 13 points in the Mental State Mini Examination ( MMSE) if they are illiterate or 19 points are read. The exclusion criteria were those who did not feel well during the technique and those who for any reason wished to withdraw from the research regardless of the phase of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-44cvfnq	Effects of a meditation and mindfulness program on the mental health of medical students	Data analysis completed	Intervention	2025-02-26	<NULL>	<NULL>	7836	Impact of a Mindfulness-Based Stress Reduction Program on medical students: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-29	Universidade do Grande Rio Professor José de Souza Herdy	Escola de Medicina e Cirurgia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO)	https://ensaiosclinicos.gov.br/rg/RBR-44cvfnq	<NULL>	Medical students from Universidade do Grande Rio Professor José de Souza Herdy (UNIGRANRIO); both genders; own a smartphone with WhatsApp® and internet access; aged 18 years or older; provide written informed consent	Previous diagnosis of decompensated psychiatric disorders; inability to attend in-person sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-3c62gy	Effects of a mindfulness program on emotional intelligence and resilience in nursing leadership	Recruitment completed	Intervention	2020-03-04	<NULL>	<NULL>	5612	Effects of a mindfulness program on emotional intelligence and resilience in nursing leadership	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Universidade Federal de São Paulo	Secretaria Municipal de Sáude - Prefeitura Municipal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3c62gy	<NULL>	Volunteers leadership nurse managers, on the hospital&apos;s humanization and family health team of the municipal government of São Paulo (Brazil)	Volunteers who practice meditation regularly; problems with alcohol and/or drug abuse; diagnosis of mental illness or psychiatric treatment assessed the Sociodemographic and Clinical Questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3k9stq8	Effects of a mindfulness program on emotional intelligence and stress in public school teachers	Recruiting	Intervention	2023-06-16	<NULL>	<NULL>	6152	Burnout and emotional intelligence: assessment of the effects of an intervention program based on Mindfulness on public school teachers	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3k9stq8	<NULL>	Be over 18 years of age; to be a teacher in any public school in Brazil; be available to participate in eight sessions of the intervention	Have participated in any Mindfulness-based intervention or have had regular practice in the last 3 months; present a diagnosis of major depressive episode or manic or hypomanic episode or psychotic disorder or substance use disorder in the last 12 months; be at risk of suicide	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-3gc2sqb	Effects of a mindfulness-based intervention on nurse leaders&apos; emotional intelligence, self-compassion and resilience	Not yet recruiting	Intervention	2025-02-14	<NULL>	<NULL>	7747	Effects of a mindfulness-based intervention on nurse leaders&apos; emotional intelligence, self-compassion and resilience: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-28	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3gc2sqb	<NULL>	Volunteer nurse leaders, hired by the São Paulo Hospital and Outpatient Clinics, Prof. Dr. Waldemar de Carvalho Pinto General Hospital of Guarulhos, State Hospital of Diadema Governador Orestes Quercia, General Hospital of Pedreira, and Municipal Hospital of Barueri Dr. Francisco Moran, São Paulo, Brazil; be 18 years of age or older; both sexes	Be a daily practitioner of any type of practice that uses mindfulness (such as: Yoga, Tai Chi Chuan, Chi Kung, among others), as indicated by the Sociodemographic and Clinical Questionnaire (QSDC); participants with a diagnosis and/or treatment for psychosis or schizophrenia, as indicated by the QSDC; participants who present suicidal ideation or severe depression, as scored by the Patient Health Questionnaire-9 (PHQ-9), 20 points or more for cutoff; participants who have problems with alcohol and drug abuse, as verified by the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) questionnaire, 26 points or more for cutoff	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-4xc76cr	Effects of a Mindfulness-based intervention on stress symptoms, depressive symptoms and quality of life in patients with Recurrent Pregnancy Loss	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7183	The importance of the Mindfulness technique in reducing depression, stress, improvement quality of life and inflammation in women who have experienced Recurrent Pregnancy Loss	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-07	Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4xc76cr	<NULL>	Women over 18 years old; women with at least 2 miscarriages (excluding ectopic or molar pregnancies) being followed up at the Recurrent Pregnancy Loss outpatient clinic at Hospital das Clínicas da Universidade Federal de Minas Gerais (HC-UFMG); possess an electronic device (cell phone, computer or tablet) with internet access	Chronic inflammatory and autoimmune diseases; insanity; smoking; inability to answer the questionnaires; do not have an electronic device (cell phone, computer or tablet) with internet access	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-76pk39r	Effects of a motor training program integrated with cognitive, behavioral, and narrative strategies in children with autism	Recruitment completed	Intervention	2025-10-21	<NULL>	<NULL>	8432	Global integration method (MIG): a mixed-methods RCT on the effects of a motor training program integrated with cognitive, behavioral, and narrative strategies in children with autism	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Instituto de neurodesenvolvimento, cognição e educação inclusiva	Faculdade de Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-76pk39r	<NULL>	Participants diagnosed with Autism Spectrum Disorder (ASD); aged between 6 and 12 years at the start of the intervention and classified as levels 1 or 2 of support	Participants with cognitive, behavioral or medical changes that prevent them from following instructions and safely participating in activities proposed in the intervention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-8mqt4m	Effects of a multi-component training program on physical fitness and risk of falls in the elderly	Data analysis completed	Intervention	2020-08-05	<NULL>	<NULL>	4089	Effects of a multilateral training program on pjysical fitness and parameters related to the risk of falls in older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-21	Universidade Federal do Paraná	Gleber Pereira	https://ensaiosclinicos.gov.br/rg/RBR-8mqt4m	<NULL>	Older adults; both genders; able to perform standardized exercises; present a medical certificate proving that they are clinically able to perform physical exercises; accept to participate voluntarily by signing a free and informed consent form	Older adults who participated in less than 70% of sessions; older adults who had some type of injury severe in the last six months prior to the study, which prevented them from performing all scheduled exercises and assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-27sf3w5	Effects of a Multiprofessional Intervention on the Health of Elderly Individuals After COVID-19	Not yet recruiting	Intervention	2025-11-04	<NULL>	<NULL>	8501	Effects of a Multiprofessional Intervention on Health-Related Physical Fitness, Nutritional Profile, and Mental Health of Elderly People Post-Covid-19 According to Nutritional Status: A Clinical Trial	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-11	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Older adults of both sexes aged between 60 and 79 years, with persistent post-COVID-19 symptoms or without a history of COVID-19 infection, who are physically able to perform moderate to vigorous intensity physical exercise and available to regularly participate in the project activities will be included	Participants with debilitating neurological diseases such as Alzheimer’s disease; Parkinson’s disease, or plegias; or those with reduced intellectual capacity; will not be eligible for this study. Individuals currently using corticosteroids or with chronic or acute conditions that contraindicate physical exercise or may alter the response to the intervention will be excluded. Participants with disabling atherosclerotic disease, class 4 congestive heart failure, active rheumatoid arthritis, advanced renal or hepatic disease, undergoing chemotherapy for cancer, or other similar conditions will also be excluded. Finally, participants who attend less than 85% of the intervention sessions will not be considered	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:20
RBR-76tbqs	Effects of a natural compound on the musculature and strength of individuals who exercised and received bodybuilding training	Recruitment completed	Intervention	2018-01-31	<NULL>	<NULL>	2465	Effects of urinary acid on muscle mass and strength in physically active individuals undergoing resistance training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-30	Faculdade de Nutrição	Faculdade de Educação Física e Dança	https://ensaiosclinicos.gov.br/rg/RBR-76tbqs	<NULL>	adult men, healthy, physically active (who performed some physical exercise, minimum duration of 150 minutes per week for at least six months, being optional strength training), age between 18 and 35 years, BMI&gt; 18.5 and &lt;29 kg / m², with availability to train three times a week in the Faculty of Physical Education of the Federal University of Goiás (FEFD / UFG), in the evening period, average protein intake of 1.6 g / kg without supplementation and that they agreed to suspend their physical activities during the study period.	"individuals who reported using supplements
(including vitamins), were smokers, had heart disease, liver disease, leukopenia, thrombocytopenia, pancreatitis, gallstones, kidney disease, diabetes, pneumonia, sepsis or infection and dysphagia for capsules."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-6pq5f74	Effects of a Physical and Cognitive Exercises program in community-dwelling elderly gait	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5650	Effects of a dual-task Exercises Program in community-dwelling elderly gait	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Secretaria Municipal de Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6pq5f74	<NULL>	60 years of age or older; live in Porto Alegre; be available to participate in the program on the days and times established; be physically independent	To have physical limitations that make it impossible to perform the proposed exercises; having uncontrolled chronic diseases; disabling pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-7xzhkn	Effects of a physical exercise program and health advice on the sedentary behavior of adolescents	Data analysis completed	Intervention	2020-09-29	<NULL>	<NULL>	4306	Stand up: for a healthier life	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7xzhkn	<NULL>	Belong to the seventh, eighth or ninth grade of elementary school; belong to the first year of high school; healthy volunteers; both genders; age between 13 and 16 years.	Age under 13 years; age 17 years or older; physical or mental condition that made it impossible to participate in the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-7dpnb52	Effects of a physical exercise program for the elderly	Recruitment completed	Intervention	2025-09-01	<NULL>	<NULL>	8246	Active aging: effects of an exercise program	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-17	Profa. Dra. Iane de Paiva Novais	Universidade Estadual do Sudoeste da Bahia - UESB	https://ensaiosclinicos.gov.br/rg/RBR-7dpnb52	<NULL>	Be female; be between 45 and 75 years old; be post-menopausal, have not had a menstrual cycle for at least 12 months and present a medical certificate authorizing the practice of physical activity	Being a smoker; not having control over blood pressure or blood sugar levels; using hormone replacement therapy and having a contraindication to performing physical exercises, identified through the Physical Activity Readiness Questionnaire (PAR-Q)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-6djxqz	Effects of a physical exercise program on cardiac function of patients with Heart Failure	Recruiting	Intervention	2020-01-15	<NULL>	<NULL>	3375	Effects of a combined physical exercise program on cardiac function and biochemical and cardiovascular genetic markers of patients with heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Hospital das Clínicas da Faculdade de Medicina de Botucatu	"Faculdade de Medicina de Botucatu (FMB) - Universidade Estadual Paulista ""Júlio de Mesquita Filho"" (UNESP)"	https://ensaiosclinicos.gov.br/rg/RBR-6djxqz	<NULL>	Will be included participants older than 18 years; both sexes; heart failure with reduced ejection fraction (HFrEF) of various etiologies and optimized drug therapy.	Patients with heart failure grade III and IV and stage D; Hypertrophic cardiomyopathy; Deposit diseases; Mitral and aortic stenosis; Decompensated heart failure in the last three months; Persistent or permanent atrial fibrillation and/or artificial pacemaker rhythm; Chronic obstructive pulmonary disease; Biomechanical limitations that prevent them from participating in the proposed combined physical exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-4xcrxcm	Effects of a physical exercise treatment before hemodialysis sessions on motor skill, cognition and quality of life outcomes: a randomized clinical trial	Not yet recruiting	Intervention	2022-02-22	<NULL>	<NULL>	5238	Chronic effects of a physical exercise intervention prior to hemodialysis sessions on Motor Performance, Cognition and Quality of Life outcomes: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Universidade Federal de Pelotas	Hospital Universitário São Francisco de Paula	https://ensaiosclinicos.gov.br/rg/RBR-4xcrxcm	<NULL>	Individuals diagnosed with chronic kidney disease on renal replacement therapy by hemodialysis; aged 50 or over; of both sexes; individuals on hemodialysis for at least three months with a minimum frequency of three times a week.	Individuals with a clinical diagnosis of musculoskeletal limitations; visual and auditory disturbances that prevent the performance of the tests; individuals with catheter in femoral or jugular vein; blood pressure equal to or greater than 220/110 mmHg or equal to or less than 100/60 mmHg; individuals who perform structured physical exercise, class III and IV angina; uncontrolled diabetics; cardiac arrhythmias; heart failure class III or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-68zp3c	Effects of a physical therapy technique on the feet on the balance of elderly	data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	76	Immediate effects of mobilization of the talocrural joint on the static and dinamic balance of elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-04	Universidade Metodista de Piracicaba	Adriana Pertille	https://ensaiosclinicos.gov.br/rg/RBR-68zp3c	<NULL>	"Age between 65 and 80 years; 
Male or female;
Walking without assistive devices for walking;
Normal skin sensitivity in the ankles and feet;
Without cognitive impairment."	"Amputation or use of prosthetic;
Neurological sequelae; 
Fractures in the lower limbs or spine after age 65; 
Severe coronary artery disease;
Labyrinth disease;
Diagnosed neuropathy and foot deformity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-73c67m	Effects of a physical training with video game and food supplementation with protein on muscle mass and balance in pre-frail older people	Recruiting	Intervention	2017-01-02	<NULL>	<NULL>	1748	Effects of physical training program with virtual games and protein supplementation (WiiProtein) on musculoskeletal function and the risk of falls in pre-frail older people.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-16	Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-73c67m	<NULL>	Both sexes; aged 65 years or over; to present itself as pre-fragile; not presenting with an acute disease or terminal illness; no metabolic instability or decompensated cardiovascular disease; do not present untreated thyroid disease; not having type I diabetes; be carriers of controlled type II diabetes, provided they present values ??of glycated hemoglobin between 8-9%; do not use medications that may affect muscle metabolism such as corticosteroids and hormones; not making use of nutritional supplement (caloric-protein); present adequate renal function (GFR&gt;60mL/min); did not present cognitive alterations according to the Mini Mental State Examination; do not present significant cognitive disturbances (vision/hearing) that prevent the understanding/execution of the evaluations and protocol of proposed exercises; to have independent gait for an 8-meter flat course, with or without assisted equipment; and functionality in the lower limbs evaluated by the Lequesne Algofunctional Questionnaire for the hip and knee joint with a score of less than or equal to 7 points for each joint separately by the Foot and Ankle Outcome Questionnaire - FAOS score above 75 points; not presenting neurological and/or orthopedic diseases with fixation or prostheses with metallic or non-metallic implants that prevent the performance of the evaluations and/or exercises proposed; osteoporosis with no history of previous fractures; the patient was not suffering from severe deficiencies diagnosed and described in the chart: cardiac, respiratory, hepatic and decompensated arterial hypertension. Have no previous history of fractures in the lower limbs and spine that prevents the full realization of the evaluations and exercises proposed for this study; not to use drugs that affect the balance; do not present any type of intolerance/allergy to milk protein; no visual impairment assessed by the Snellen card, and if participants exhibit borderline visual acuity (e.g.: one eye with 20/70 and the other presenting a single error reading the same line), it will be considered as a visual impairment, and it is considered acceptable to include in the study, in the case of presenting some visual function deficiency, to use the correction through the use of glasses or lenses	Elderly who report pain in any body region or other region that limits the evaluation and/or execution of physical training exercises; With diagnosis of neurological and/or orthopedic diseases with fixation or prosthesis with metallic or nonmetallic implants, cardiac, respiratory, renal, hepatic, diabetes, endocrine and decompensated hypertension; and elderly people not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-4hskt2d	Effects of a preoperative home exercise program: physical-functional and hospital outcomes in patients undergoing knee surgery	Not yet recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7847	Effects of a preoperative home exercise program: physical-functional and hospital outcomes in patients undergoing total knee arthroplasty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-21	Ministério da Saúde	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	https://ensaiosclinicos.gov.br/rg/RBR-4hskt2d	<NULL>	Patients diagnosed with knee osteoarthritis who have been selected for total knee arthroplasty by their physician; both genders; aged between 50 and 75 years; who have signed the Free and Informed Consent Form; able to perform the exercises proposed in the home training program; availability for telerehabilitation sessions and WhatsApp for supervised video conferences	Patients who do not respond to scheduled telerehabilitation sessions or communication via WhatsApp; patients who present unexpected medical complications that prevent continuity or safety in the exercise program will be instructed to immediately stop exercising and excluded from the study; changes in the clinical condition that result in surgical contraindication or new injuries during the pre-rehabilitation period that make participation in home exercises unfeasible will also be grounds for exclusion; patients who present scores below the values ​​suggested by the Ministry of Health in the Mini Mental State Examination (MMSE) due to the possibility of inability to adequately understand the tests and the intervention protocol; are involved in another physical exercise program that has a frequency equal to or greater than once a week; have any other medical condition that prevents safe participation in the exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-7ph66k	Effects of a program of behavior change for Primary Health Care workers	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3744	Effects of a behavior change program for a healthy lifestyle of primary health care workers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7ph66k	<NULL>	Primary health care professionals; Age between 18 and 60 years old.	Do not participate in 85% of the meetings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-63kf95	Effects of a program of exercises with increasing weight for individuals with coronary artery disease	Recruiting	Intervention	2014-06-10	<NULL>	<NULL>	303	Effects of a resistance physical exercise program based on determination of anaerobic threshold in increasing resistance testing in patients with coronary artery disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-63kf95	<NULL>	Mens with aged between 50 and 82 y,with a clinical diagnosis of coronary artery disease, with at least 12 months after the acute event or 12 months after surgical or percutaneous revascularization, nonsmoking, non-alcoholic, non-users of drugs that cause addiction, presence of clinical stability, absence of acute exacerbations of the disease, anaemias in general, electrolyte disturbances and / or uncompensated metabolic, absence of permanent pacemaker or defibrillator implants or valve, absence of respiratory disorders, signs of ischemia or ST segment depression, complex arrhythmias, left ventricular dysfunction, and absence of neurological, neuromuscular, musculoskeletal and osteoarticular disabling, controlled blood pressure and level of understanding that does not prevent the implementation the proposed protocol.	Smokers, women, people with impaired muscle and bone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-4g7q2c	Effects of a program of strengthening exercise in subjects with Parkinson&apos;s disease	recruitment completed	Intervention	2012-07-16	<NULL>	<NULL>	114	Strengthening exercise in individuals with parkinson´s disease: A randomised trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-15	Universidade Federal de Minas Gerais-UFMG	Universidade Federal de Minas Gerais-UFMG	https://ensaiosclinicos.gov.br/rg/RBR-4g7q2c	<NULL>	"Are older than 50 years of age;
Have a diagnosis of PD; 
In stages I to IV of the Disability Stages of Hoehn &amp; Yahr;
Be stable use of anti-parkinsonian;
Have good comprehension (assessed using the Mini Mental State Examination score);
Signing the informed consent"	"Adverse medical conditions that may prevent participation in the proposed protocols as decompensated hypertension, neurological diseases or other rheumatic diseases of any kind;
Individuals who are in physical therapy for at least 02 months before the randomisation procedure."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-34mxpw	Effects of a program that assists parents in their child&apos;s education	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2689	Effects of a program to promote positive parenting practices in a socially vulnerable context	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Medicina de Botucatu	Secretaria Municipal de Assistência Social  de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-34mxpw	<NULL>	part of the &quot;Cheers Milk&quot; program	caregivers of children under 2 years old; people with significant cognitive and/or emotional difficulty; more than 3 absences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-5nct6d	Effects of a Protocol in a Cellular Application for the prescription of Anticoagulants in the public health system in the city of Ijuí/RS	Recruiting	Intervention	2017-11-16	<NULL>	<NULL>	1481	Evaluation of the Efficacy of a Protocol for patients Anticoagulants of the public health system in the city of Ijuí/RS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-5nct6d	<NULL>	Physicians working in the basic health unit; regardless of gender, age, years of graduation and years in the unit	There are no criteria for physician exclusion; except personal refusal; risk of cross-contamination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-3z23ts	Effects of a protocol of respiratory care in patients with Amyotrophic Lateral Sclerosis	Not yet recruiting	Intervention	2019-12-17	<NULL>	<NULL>	4499	Effects of an optimized respiratory care protocol in patients with amyotrophic lateral sclerosis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3z23ts	<NULL>	Inclusion criteria for the study were patients with ALS, between 18 and 70 years old, with good cognitive level to understand the evaluative tests; patients not restricted to bed; the presence of a responsible caregiver who accepts the training and follows the program; have a telephone to contact the service team.	Will be excluded from the study volunteers who are unable to perform the requested maneuvers correctly or who give up performing them during the execution for evaluation. Patients with cardiac, respiratory, musculoskeletal comorbidities, intellectual comprehension difficulty or dementia evaluated, with any other comorbidity that prevents them from performing the tests or who have difficulty performing the tests; and, smoking patients. Patients residing in regions that do not have rear medical staff in the city or in a nearby urban center; patients residing in regions of high hazard or difficult for physiotherapists to access.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-8qby2wt	Effects of a remotely supervised Home-based Program, during the Covid-19 pandemic, on the Functional Capacity and Cognitive Function of community-dwelling elderly: a randomized clinical trial	Data analysis completed	Intervention	2021-05-08	<NULL>	<NULL>	5779	Effects of a remotely supervised Home-based Program, during the Covid-19 pandemic, on the Functional Capacity and Cognitive Function of community-dwelling elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal Rural de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8qby2wt	<NULL>	Volunteers with self-sufficient visual and auditory capacity; at least one electronic device that has a front camera; Internet access; relative or guardian available to assist in interventions	Decompensated health diagnoses, high-risk cardiovascular diseases, grade four or five knee osteoarthritis, taking medication that may compromise mobility, functionality and cognition; neurodegenerative diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-86xv46	Effects of a school intervention on adolescent health	Not yet recruiting	Intervention	2019-12-11	<NULL>	<NULL>	3273	Effects of a school-based intervention on executive function, sedentary behavior and nutritional status of adolescents	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Departamento de Saúde Coletiva da Universidade Federal do Rio Grande do Norte	Departamento de Saúde Coletiva da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-86xv46	<NULL>	State public schools that work with elementary school from 7th to 9th grade; Have spaces for the practice of physical activities, such as courts and gyms; Adolescents between 12 and 16 years old and properly enrolled.	Physical disability; Intellectual disability; Endocrine disorders; Cardiovascular disease; Diabetes mellitus; Be pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-5cyvzh9	Effects of a semi-supervised home-based exercise training on physical, mental performance and body composition on primary lung and head and/or neck cancer patients: a randomized clinical trial	Not yet recruiting	Intervention	2021-02-12	<NULL>	<NULL>	4549	Effects of a semi-supervised home-based exercise training on physical performance, biological and mental outcomes on primary lung and head, and/or neck cancer patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-15	Universidade Estadual Julio de Mesquita Filho - UNESP	Ercy Mara Cipulo Ramos	https://ensaiosclinicos.gov.br/rg/RBR-5cyvzh9	<NULL>	Diagnosis of primary lung or head and/or neck cancer; older than 18 years; being literate or has a family member who helps with daily training; having a schedule of oncology treatment (radiotherapy, chemotherapy or both); ECOG between 0 and 2;  more than six months of medical prognosis; do not have uncontrolled metabolic diseases; do not have cognitive changes that can interfere the training; do not have musculoskeletal and cardiovascular changes that can interfere the training	Primary cancer from another organ with pulmonary or head and/or neck metastasis; symptomatic brain metastasis that can interfere in the training; symptomatic bone metastasis that can interfere in the training; patient under palliative care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-7z858k	Effects of a set of muscle strengthening exercises for upper limbs in individuals with Parkinson&apos;s Disease	Recruitment completed	Intervention	2017-05-19	<NULL>	<NULL>	1237	Effects of a strength training protocol and muscular endurance for upper limbs in individuals with Parkinson&apos;s Disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Thais Vianna Corrêa	Escola de Educação Física e Desporto da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7z858k	<NULL>	Clinical diagnosis of idiopathic PD confirmed by Neurologist; Age range between 50-75 years of both sexes; Hoehn &amp; Yahr modified stage between 2-3; Be able to understand and obey verbal commands, obtaining a minimum of 23 points for the Montreal Cognitive Assessment (MoCA)	Have undergone surgical treatment related to PD; To present systolic pressure superior to the 180mmHg and Diastolic superior to the 100mmHg, besides unstable cardiopathy or insufficiency cardiorespiratory; To present impairment of the mental and cognitive state identified by MoCA; To present neurological and / or traumatic-orthopedic affections that compromise the function of the upper limbs and / or spine; Have undergone changes in dose and / or medication after initial evaluation and during training; Have performed an exercise program with Physical Therapy or Physical Education professionals, in addition to sports practice, in the last 3 months before beginning the training; Do not carry out all sessions of the training program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-2j7hbf	Effects of a shoulder joint strengthening program on muscular balance and throwing	Data analysis completed	Intervention	2016-03-08	<NULL>	<NULL>	741	Effect of shoulder external rotator eccentric strengthening program on strength balance and on throwing speed and accuracy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2j7hbf	<NULL>	Female handball atlhetes volunteers; attended at least one full competitive season; without upper limb injury for at least six months	Volunteers feeling pain; swelling; inability to perform physical exercises; symptomatic or asymptomatic orthopedic injuries associated with upper limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-5wz8jp7	Effects of a silver-based mouthwash on the treatment of gum inflammation caused by dental plaque	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9169	Effects of a Silver Nanoparticle-Based Mouthwash in the Treatment of Biofilm-Induced Generalized Gingivitis	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Evangelica de Goiás	<NULL>	<NULL>	<NULL>	Adult individuals (≥18 years) of both sexes will be included; systemically healthy (absence of diagnosed systemic diseases that may interfere with the inflammatory response or periodontal healing); with the presence of biofilm-induced gingivitis, characterized by: bleeding on probing (BOP) in &gt;30% of the evaluated sites, probing depth ≤3 mm in all sites, absence of clinical attachment loss and absence of radiographic bone loss; presence of at least 20 fully erupted permanent teeth (excluding third molars); capacity and willingness to understand and sign the Informed Consent Form and adhere to the study protocol.	The following will be excluded: pregnant or breastfeeding women; individuals with systemic diseases that may interfere with periodontal condition or response to treatment (e.g., uncontrolled diabetes mellitus, immunosuppressive diseases); use of antibiotics, anti-inflammatory drugs, or immunosuppressants in the last 3 months; previous history or current presence of periodontitis (according to clinical and radiographic criteria); presence of gingival diseases not induced by biofilm (e.g., drug-induced gingivitis, mucocutaneous diseases); smokers or former smokers who quit less than 12 months ago; presence of extensive prostheses or conditions that hinder periodontal evaluation; periodontal therapy performed in the last 6 months; need for antibiotic prophylaxis for routine dental procedures; known allergy to any components of the formulations used in the study; individuals who are legally incapacitated or have limitations that prevent compliance with the protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-6wfxyn	Effects of a single dose of beet juice on the vessel function of patients with hypertension	Recruiting	Intervention	2019-05-03	<NULL>	<NULL>	2655	Acute effects of sugar beet intake on the vascular function of hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-20	Hospital Universitário Pedro Ernesto - HUPE	Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ	https://ensaiosclinicos.gov.br/rg/RBR-6wfxyn	<NULL>	Patients of both sexes; age between 45 and 70 years; previous diagnosis of primary systemic arterial hypertension, signed the Informed Consent Term.	Secondary hypertension; systolic blood pressure greater than or equal to 180 mmHg or diastolic BP greater than or equal to 110 mmHg; in use of beta-blockers; with diabetes mellitus; history of cancer; in use of any dietary supplement; any serious life-threatening illness; cardiovascular diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-867k9g	Effects of a single session of Exercise in the blood pressure of patients with Rheumatoid Arthritis and High Blood Pressure	Recruiting	Intervention	2019-12-13	<NULL>	<NULL>	3288	Effects of a single session of Aerobic Exercise on blood pressure at rest, in response to stressful stimuli and in ambulatory conditions in Hypertensive patients with Rheumatoid Arthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-21	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)	Faculdade de Medicina, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-867k9g	<NULL>	Female sex; 20-60 years; hypertension; rheumatoid arthritis diagnosis; under usual care of the rheumatoid arthritis outpatient care at the Hospital das Clínicas of the Faculdade de Medicina of the Universidade de São Paulo.	Established cardiovascular and metabolic diseases; musculoskeletal problems that preclude the participation in exercise; ischemia or severe arrhythmias at rest or in the exercise test; class II obesity; use of medication that directly affect the autonomic nervous system (beta-blockers and non-dihidropiridin calcium blockers).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-103g8nwg	Effects of a single session of Physical Exercise performed in Immersive Virtual Reality and Exergame in young adults subjected to Unpleasant Stimulus	Not yet recruiting	Intervention	2024-03-22	<NULL>	<NULL>	6886	Comparison of the physiological and psychobiological effects of a single session of Physical Exercise carried out in Immersive Virtual Reality and Exergame in young adults subjected to Unpleasant Stimulus	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-103g8nwg	<NULL>	Do not exercise regularly and do not have significant visual impairment (i.e., everyone with normal or corrected-to-normal visual acuity)	Present contraindication to carrying out physical activity; people on their menstrual period; have a diagnosis of mood or anxiety disorders; be using any type of psychotropic drug; have abusive use or dependence on alcohol or tobacco; report some type of labyrinthopathy (Benign Paroxysmal Positional Vertigo, Ménière&apos;s Disease, Labyrinthitis, etc.); not answering any study question; discontinuity of tests; and not being literate (due to the need to respond to questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-55g4q3	Effects of a stretching program of the posterior muscles in patients with temporomandibular dysfunction	Other	Intervention	2016-04-01	<NULL>	<NULL>	776	Assessment of pain and mouth opening range of motion in patients with temporomandibular disorders subjected to stretching of the posterior chain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Universidade Sagrado Coração	Universidade Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-55g4q3	<NULL>	Study participants; females; in the age group 20-50 years. diagnosed with temporomandibular dysfunction; who do not use drugs and are not performing any other intervention.	They will be excluded from the study that individuals are making use of analgesic drugs and aantiinflamatório ; also some other type of physical therapy intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-10jytbhj	Effects of a swallowing maneuver on the risk of choking in patients with partial laryngeal surgery.	Recruitment completed	Intervention	2023-08-26	<NULL>	<NULL>	6390	Impacts of the shaker maneuver on the risk of aspiration in patients undergoing open partial horizontal laryngectomy	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-06-06	Instituto Nacional do Câncer - INCA	Instituto Nacional do Câncer - INCA	https://ensaiosclinicos.gov.br/rg/RBR-10jytbhj	<NULL>	Patients from the Head and Neck Sector of INCA will be included. They performed all oncological treatment at the institution. Undergoing partial laryngectomy reconstructed with CHEP; with or without adjuvant radiotherapy. Who concluded radiotherapy at least 6 months ago until the moment of the speech therapy intervention of the study. Patients capable of carrying out the strategies requested for the study on their own; both physically and cognitively. Available to come to consultations once every two weeks for clinical evaluation, monitoring of exercise performance and guidance on proper execution at home.	Are using any other alternative feeding route. Previously diagnosed central or peripheral neurological alteration that interferes with the swallowing function. Surgical or oncological intervention during the period of speech therapy intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-7yxnmv	Effects of a technique applied by the hands of the therapist in the thoracic spine in patients with temporomandibular joint and cervical disorders	not yet recruiting	Intervention	2012-02-13	<NULL>	<NULL>	88	Effects of high thoracic spine manipulation on temporomandibular and cervical disorders	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-26	Universidade Metodista de Piracicaba	Delaine Rodrigues Bigaton	https://ensaiosclinicos.gov.br/rg/RBR-7yxnmv	<NULL>	"All volunteers must have:
Diagnosis of temporomandibular disorders (TMD) according to the RDC / TMD (Ia, Ib, IIa, IIb, IIc and IIIa);
Pain and / or fatigue in the masticatory muscles during functional activities for a minimum period of 3 months;
Neck pain for at least 3 months;
Diagnosed with cervical dysfunction according to the neck Disability Index (NDI);
Body Mass Index (BMI) less than 25;
Scores of pain in the masticatory muscles and cervical greater than 3 cm according to the VAS."	"Missing teeth;
Open bite;
Cross bite;
Complete dentures;
Partial systemic neuromuscular diseases;
History of trauma to the face and / or TMJ;
Joint dislocation;
In orthodontic treatment and / or medication actually affecting the musculoskeletal system (pain relievers anti-inflammatories and muscle relaxants);
Red flag as a sign of malignant, infectious or inflammatory disease that contraindicate the use of manual therapy;
Occurrence of cervical whiplash;
Previous surgery of the cervical spine;
Diagnosis of fibromyalgia;
Previous experience with management over the past two months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-2dwhkm	Effects of a technique using apparatus and one using manual technique both for removal of bronchial secretions in hospitalized children.	Not yet recruiting	Intervention	2016-04-27	<NULL>	<NULL>	816	Effects of a new vibrotherapy instrument &quot;Pulsar&quot; and vibro in children in the hospital	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-2dwhkm	<NULL>	Both genders; aged between 29 days to 3 years old; who require respiratory therapy in the first 48 hours of hospitalization.	Clinical situations that respiratory physiotherapy this contraindicated as bleeding with hemodynamic instability, intracranial pressure higher than 20 mmHg; chest tube; pneumothorax; open wounds and chest skin infections; osteomyelitis of the ribs; osteoporosis and rib fracture.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-3knbwp	Effects of a therapeutic exercise program associated or not with electrical currents in patients with chronic neck pain	Not yet recruiting	Intervention	2018-01-17	<NULL>	<NULL>	1573	Effects of a program of therapeutic exercises associated or not to electrotherapy in patients with chronic neck pain: blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3knbwp	<NULL>	Individuals of both genders; aged between 18 and 45 years; and with chronic cervicalgia (for more than 90 days).	Individuals who presented a history of cervical trauma; head, face or cervical surgery; cervical hernia; degenerative diseases of the spine; pain radiated to the upper limbs; have undergone physiotherapeutic treatment for the cervical region in the last three months; use of analgesic, anti-inflammatory or muscle relaxants in the last week; presence of systemic diseases; medical diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9gchqr	Effects of a training in ensuring long term improvement of knowledge, attitudes and practices of community health workers in maternal and infant health	Data analysis completed	Intervention	2018-07-31	<NULL>	<NULL>	2073	Innovations in maternal and child care in Pernambuco - Quality evaluation cycle of maternal fetal care in maternity hospitals in Pernambuco	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq),	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-9gchqr	<NULL>	Community Health Workers who work in Family Health Units that are co-managed by the municipal health authority of Recife and the Institute of Integral Medicine Professor Fernando Figueira (IMIP).	Community Health Workers who were on vacation or on any type of leave during the data collection periods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3vqhv5d	Effects of a training program involving vascular Occlusion and Jumping on the functionality of elderly people	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8497	Effects of a training program involving Ischemic Preconditioning and Jumps on the functionality and power of the lower limbs of elderly individuals: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-05	Universidade São Judas Tadeu	<NULL>	<NULL>	<NULL>	Individuals of both sexes will be included; aged ≥ 60 years and &lt; 71 years; who are available to participate in the intervention program at least three times a week for 12 weeks	Participants with the following clinical conditions will be excluded: recent acute myocardial infarction or unstable angina; uncontrolled atrial or ventricular arrhythmias; dissecting aortic aneurysm; severe aortic stenosis; acute endocarditis or pericarditis; uncontrolled arterial hypertension; acute thromboembolic disease; severe acute heart failure; severe acute respiratory failure; uncontrolled orthostatic hypotension; diabetes mellitus with acute decompensation or uncontrolled hypoglycemia; recent fracture (in the last month); or any other medical condition that prevents the performance of the physical activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:14
RBR-2p4mz5	Effects of a training protocol for breathing musculature in patients undergoing coronary artery bypass grafting	Data analysis completed	Intervention	2018-05-02	<NULL>	<NULL>	7121	Effects of a respiratory muscle training protocol with POWERBreathe® in patients undergoing coronary artery bypass grafting with with extracorporeal circulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de Alfenas - UNIFAL MG	Hospital e Maternidade Santa Lúcia - Hospital do Coração	https://ensaiosclinicos.gov.br/rg/RBR-2p4mz5	<NULL>	Individuals with coronary artery disease with elective indication for myocardial revascularization with extracorporeal circulation; age 18 and over,with a maximum limit of 80 years;of both sexes; who are able to perform physical and respiratory tests; in addition to having signed the consent form	Individuals presenting a diagnosis of neurological and / or cognitive impairment, neuromuscular diseases, history of previous pulmonary surgery; associated heart surgery; presence of aneurysm; in use of muscle relaxants in the preoperative period and present cardiovascular instability during the preoperative evaluation period and during the postoperative protocol; individuals who can not perform the necessary procedures; quit participating in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-7vznbt	Effects of a Treadmill Walking Program on stationary and moving balance in the elderly in nursing homes	Not yet recruiting	Intervention	2018-11-06	<NULL>	<NULL>	2316	Effectiveness of a Treadmill Training Programme in improving the postural balance on institutionalized older adults	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7vznbt	<NULL>	Functional Ambulation Categories (FAC) &gt;2; absence of cognitive deficit in the Mini-Mental State Examination (MMSE) according to educational level; absence of physical and/or functional impairment that would limit treadmill walking.	Untreated neurological or cardiorespiratory diseases; limitation of the ability to walk on the treadmill; incapacitating visual or hearing deficits that would not permit the investigation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9jv27c	Effects of a treatment performed with elastic tubings on heart, capacity of exercise and  muscle strength in pulmonary disease	Recruiting	Intervention	2015-10-15	<NULL>	<NULL>	635	Effects of a Resistance Training performed with elastic tubings on cardiac autonomic modulation, cardiopulmonary functional capacity and peripheral muscle strength in Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-21	Universidade Federal de São Paulo	Universidade Estadual de São Paulo - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9jv27c	<NULL>	COPD diagnosis; absence of cardiovascular diseases; absence of neuromuscular or skeletal reported diseases; absence of contraindications or any impediment to completion of the experimental protocol	"Individuals who do not produce at least 95% of sinus beats in the time series of intervals between beats will be deleted 
consecutive heart used in the analysis of heart rate variability; individuals as you do not complete the protocol experimental and who present clinical instability during the treatent"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-2qp9gtg	Effects of a Treatment using the Pilates Method in patients with Back Pain	Recruiting	Intervention	2024-03-27	<NULL>	<NULL>	6897	Effects of a treatment Protocol using the Pilates Method in patients with Chronic Non-specific Low Back Pain	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-11-21	Fundação Presidente Antonio Carlos	Fundação Presidente Antonio Carlos	https://ensaiosclinicos.gov.br/rg/RBR-2qp9gtg	<NULL>	Individuals of both sexes; aged between 20 and 59 years; with chronic non-specific low back pain, lasting at least 3 months; who are not undergoing physiotherapy or practicing Pilates	Not meeting the inclusion criteria; presence of pain radiating to the lower limbs; fibromyalgia; pregnancy; neurological or cognitive diseases; cardiovascular diseases and morbid obesity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-759vsh4	Effects of a virtual game on television on elderly people living in a nursing home	Recruitment completed	Intervention	2023-11-21	<NULL>	<NULL>	6598	Effects of Virtual Reality on institutionalized elderly people: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-14	Centro Universitário Presidente Tancredo de Almeida Neves	Centro Universitário Presidente Tancredo de Almeida Neves	https://ensaiosclinicos.gov.br/rg/RBR-759vsh4	<NULL>	Elderly people aged 60 or over; of both sexes; living in a long-term care facility	Bedridden; wheelchair users; who use walking aids; history of acute and chronic physical, cognitive and mental illnesses that may make exercise difficult; who have hearing and vision problems that make it difficult to perform exercise; who present in the Mini State Examination Mental scores lower than 13 points for illiterates, 18 points for low and medium schooling and 26 points for high schooling; who present any conditions that make it impossible for them to carry out the proposed procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-9t9j3hs	Effects of a Virtual Reality Exercise program on pain in Fibromyalgia patients	Recruitment completed	Intervention	2024-03-21	<NULL>	<NULL>	6879	Virtual Reality in users with Fibromyalgia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidad San Sebastián	Universidad San Sebastián	https://ensaiosclinicos.gov.br/rg/RBR-9t9j3hs	<NULL>	Males and females; over 18 years of age; with a diagnosis of fibromyalgia issued by a medical professional under the ACR criteria (2016)	Subjects were excluded from the study when they presented pregnancy or lactation; oncologic pain; uncontrolled metabolic disorder; vertigo or similar condition or any cognitive impairment that hinders the understanding of the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-5gqgs99	Effects of a Walking Program associated with Blood Flow Restriction on strength, muscle thickness, and gait in individuals with leg strength imbalance	Not yet recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7488	Effects of a Walking Program associated with Partial Blood Flow Restriction on muscular and functional aspects in individuals with muscle strength asymmetry in lower limbs	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-20	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5gqgs99	<NULL>	Individuals aged between 18 and 59 years; muscle strength difference between lower limbs greater than or equal to 10 per cent in the knee extensor musculature (quadriceps), indicating asymmetry; medical clearance for training, granted by the physician associated with the study (Dr. Francisco Wekerlin Morozowski); signing the Informed Consent Form; completing 75 per cent of the proposed training sessions if selected for the intervention	Having conditions that prevent the completion of questionnaires, understanding of instructions, and performance of tests (e.g., severe vestibular deficits, mobility deficits, and cognitive impairment); having systolic blood pressure greater than or equal to 140 mmHg or diastolic blood pressure greater than or equal to 90 mmHg; having more than one risk factor for thromboembolism, which includes: body mass index greater than or equal to 30 kg/m². diagnosis of chronic inflammatory disease. history of pelvic, hip, and femur fractures. major surgeries in the last 6 months. diagnosis of varicose veins in the last 6 months. family history of deep vein thrombosis and pulmonary embolism. use of oral contraceptives. tobacco use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-7zcgdd	Effects of a water-based Exercise Program in elderly women with Knee Osteoarthritis	Data analysis completed	Intervention	2018-07-04	<NULL>	<NULL>	1956	Comparison of the effects of an Exercise Program performed in water or land in elderly with Hip or Knee Osteoarthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Departamento de Educação Física da Universidade Federal do Paraná	Centro Universitário Unibrasil	https://ensaiosclinicos.gov.br/rg/RBR-7zcgdd	<NULL>	Women; age from 60 years; diagnosed with knee osteoarthritis by a physician; able to walk with no help of assistive device; able to practice exercise.	Elderly women with diagnosed osteoarthritis or prosthesis in other lower limb joint; with medical restrictions to physical activity; participating on exercise program in last six months; with ortopaedic surgery in last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-4rnq3v	Effects of a workout program in patients with HIV and cocktail use for over than one  year and treated at a university hospital: a randomized clinical trial	Recruiting	Intervention	2015-06-09	<NULL>	<NULL>	511	Effects of a program of periodized resistance exercise in patients with HIV in HAART therapy more than one year and served in a university hospital: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-06	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4rnq3v	<NULL>	"Be patient infected with HIV and use of antiretrovital therapy for over one year seen at the Infectious and Parasitic Diseases sector of a university hospital. Be older than 18 and less than 60. Having health conditions for the practice of the proposed exercise. Being sedentary. Having availability displacement three times per week for the training local.
Target sample: 34 patient."	Having diagnosis of opportunistic infections in the last two years. Having a diagnosis of liver disease and/or nephropathy and/or neuropathy. Have a history of orthopedic surgery. Have an body mass index&gt; 30 kg / m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-72dvqv	Effects of açaí consumption on the health of individuals with excess weight and changes in blood fats.	Recruitment completed	Intervention	2018-08-10	<NULL>	<NULL>	2115	EFFECT OF AÇAÍ CONSUMPTION IN THE ANTIOXIDANT STATE IN THE ANSWER INFLAMMATORY AND EXPRESSION OF MICRO-RNAS IN INDIVIDUALS WITH EXCESS OF WEIGHT AND DISLIPIDEMICS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-72dvqv	<NULL>	overweight adults of both sexes, over 20 years of age, and who have dyslipidemia.	Individuals with aversion or food allergy known to açaí; Pregnant and lactating women, since the caloric restriction is not part of the food planning in these physiological conditions;  Self-reported alcoholism, as it is related to the increase in blood pressure and to alter the concentration of serum lipoproteins that are parameters in the diagnosis of dyslipidemia; Individuals on an energy restriction diet or using dietary supplements containing minerals or antioxidant vitamins, as part of the present study weight loss and antioxidant supplementation, therefore, this aspect may interfere in the results of this study; Individuals with autoimmune, infectious, cancer and AIDS diseases that may interfere with the results of the present study;  Thyroid diseases untreated and destabilized, since the thyroid regulates body metabolism, so in case of disease it may interfere in the results of the present study;  Chronic renal failure or hepatopathies, because they are diseases that compromise the whole inflammatory state and oxidative stress, besides needing nutritional care that the protocol stipulated in this project is not able to supply; Use corticosteroid substances, as it interferes with the metabolism of glucose, causing hyperglycemia and edema, which may interfere with the results of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-7qgnbn	Effects of actions to promote healthy eating and physical activity using internet technology on the health of adolescents	Recruiting	Intervention	2016-10-17	<NULL>	<NULL>	1040	Effects of promotional activities of healthy eating habits and physical activity in adolescents, use of E-Health technology, enrolled in schools based public schools in the city of Salvador-BA	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-29	Escola de Nutrição - Universidade Federal da Bahia	Faculdade de Farmácia - Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7qgnbn	<NULL>	Adolescents 10-17 years; of both sexes; enrolled in the public school system in Salvador-Bahia	Pregnant women and people with physical trauma (fixed at the time of anthropometric measurements) and systemic diseases and birth frames, except for metabolic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-9crpzc	Effects of active computer gaming  and aerobic exercise on memory, attention and physical performance in older adults	Recruitment completed	Intervention	2015-08-17	<NULL>	<NULL>	586	Cognitive performance in older adults: eletronic games, physical activity and nutrition	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Universidade Federal de Santa Catarina	Centro de Deportos da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9crpzc	<NULL>	"Individuals of both sexes (target sample = 27 subjects); aged 55 years or older;  not participating in regular exercise programs in the last three months;
who provide a medical certificate that indicates the consent to participate in physical exercise; subjects without contact videogames of games and exergames; people without visual and hearing impairment, which may hinder the identification of colors, images and sounds."	Diagnosis of Alzheimer&apos;s disease; Parkinson&apos;s disease; disabling neurological diseases; psychiatric comorbidities; neurodegenerative diseases; severe cardiovascular disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-6c7tns	Effects of active exercises on fibromyalgia	Data analysis completed	Intervention	2019-02-12	<NULL>	<NULL>	2477	Effects of a postural orientation program in patients with Fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6c7tns	<NULL>	"Women aged 30-55 years; fulfillment of the
American College of Rheumatology 1990 or 2010 criteria for diagnosis of FM [3]; residence in the metropolitan area of Recife, PE; stable psychological, physical, and drug therapy in the preceding month."	Patients attending physiotherapy sessions, using gait assistance devices, suffering from associated autoimmune rheumatic diseases, or presenting uncontrolled comorbidities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-3zty4w	Effects of active videogame system on health of children with Cerebral palsy	Recruitment completed	Intervention	2018-08-21	<NULL>	<NULL>	2137	Effects of intervention with virtual reality on the health condition of children with cerebral palsy - randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3zty4w	<NULL>	"Children to five througth twelve years old.
Diagnosis of cerebral palsy. Gross Motor Function Classification System GMFCS) I and II.
They are able to understand simple verbal commands."	"Children who do not fit the specific age group.
With bone deformities and muscle shortening limiting for the activity. Who have undergone surgery in the last year. Who have made use of botulinum toxin in the last six months. Who have sensory deficiencies (visual and / or auditory) not corrected by devices. Cardiorespiratory limitations of any intensity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-4ndjtp	Effects of Acupuncture for Pain Improvement and Quality of Life in Women with Fibromyalgia	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	1491	Effects of Acupunture at the yanglinquan point (vb-34) on quality of life in women with Fibromialgia: a pilot clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4ndjtp	<NULL>	Be between 18 and 60 years of age; be female; have a clinical diagnosis of Fibromyalgia.	To present lesions, injuries and sensitivity impairment in the skin that makes it impossible to apply the modality; use topical medications in the region of the modality; presence of scars or prostheses in the place that could compromise the insertion of the needle.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-3y733pt	Effects of Acupuncture in the treatment of hip pain caused by Osteoarthritis	Terminated	Intervention	2023-05-16	<NULL>	<NULL>	6667	Effects of Acupuncture in the treatment od chronic pain associated with Hip Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-22	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3y733pt	<NULL>	Be over 18 years old; Man or woman; Unilateral diagnosis of hip osteoarthritis according to clinical criteria; Kellgren-Lawrence grade 3 or 4 radiological classification; Failure in conservative treatment consisting of: exercises, pharmacological therapies such as analgesics or anti-inflammatory drugs, use of gait aids or no improvement when performing trigger point blocks; Pain assessed by Visual Analogue Scale greater than four; Previously not treated with acupuncture.	Limitation of understanding of assessment procedures or instruments; Difficulty in clinical follow-up and attendance to reassessments for any reason; Diagnosis of other diseases that limit functionality or assessment of pain in the lower limbs; Painful involvement of other joints of the lower limbs by Osteoarthritis; Have previous hip surgeries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5g7xqh	Effects of acupuncture on muscle strength of healthy subjects and stroke patients	data analysis completed	Intervention	2011-10-26	<NULL>	<NULL>	50	Immediate effects of manual acupuncture on the biceps brachii muscle function in healthy subjects and chronic hemiparetic patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-12	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-5g7xqh	<NULL>	"Control group: Absence of pain, trauma or musculoskeletal injuries in the upper limbs, neuromuscular diseases, pregnancy or some sort of unconfortable reaction to needling; Informed written consent signature after reading of the text and explanation of the objectives, risks and potential benefits from the participation in this research.
Hemiplegic group: Clinical diagnosis of upper neuron lesion due to stroke for at least 6 months, confirmed by image exams, both ischemic of hemorragic; Partial motor impairment of the upper limb function (hemiparesis); Absence of pain, trauma or musculoskeletal injuries in the upper limbs, neuromuscular diseases, pregnancy or some sort of unconfortable reaction to needling; Informed written consent signature after reading of the text and explanation of the objectives, risks and potential benefits from the participation in this research."	Incomplete realization of any electromyographic signal acquisition; Low quality of electromyographic signal (less than 2-out-of-3 visible contraction events).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-3njbh7w	Effects of Acupuncture on the scalp for pain relief, depression symptoms and impact on improving the quality of life of people with Fibromyalgia	Not yet recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7850	Effects of Craniopuncture on pain, depression symptoms, and impact on quality of life of people with Fibromyalgia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-03	Programa de Pós-Graduação em Enfermagem da  Universidade Federal do Rio Grande do Norte	Programa de Pós-Graduação em Enfermagem da  Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3njbh7w	<NULL>	Patients with a diagnosis of fibromyalgia obtained through the International Classification of Diseases (ICD-10) code M79 will be included. 7; patients aged 18 years or older; both sexes	Individuals with impaired cognitive ability, who are unable to understand the questions in the questionnaires; those who have other causes of pain; those who have an insurmountable fear of needles	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-5ghx4y6	Effects of acute administration of a single dose of Cannabis Extract on laboratory-induced pain: comparison with placebo	Not yet recruiting	Intervention	2023-10-26	<NULL>	<NULL>	6539	Investigation of the effects of acute administration of Full Spectrum Cannabis Extract on Experimentally Induced Pain: A randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-10-30	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo  FMRP - USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo  HCFMRP - USP	https://ensaiosclinicos.gov.br/rg/RBR-5ghx4y6	<NULL>	Participants aged at least 18 years; both genders; absence of current or previous history (self-reported) of substance abuse, psychiatric disorders and/or neurological disorders, cardiovascular diseases, pulmonary diseases, high blood pressure; absence of painful disorders and complaints of chronic or acute pain; score less than ten on the Patient Health Questionnaire (PHQ-9), on the Generalized Anxiety Instrument (GAD-7); absence of experience of pain of any kind in the seven days prior to the experimental session, assessed by means of a checklist questionnaire of pre-existing painful conditions and the perception of present pain (Visual Analog Pain Scale)	Adverse reactions of any nature after the use of cannabis extract; failure to complete the experimental tasks that make up the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5x7z9zf	Effects of acute administration of Modafinil on cognition and learning in the elderly	Recruiting	Intervention	2022-12-28	<NULL>	<NULL>	5783	Effects of acute modafinil administration on learning conditional relationships and emergence of stimulus equivalence in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-15	Faculdade de Medicina de Ribeirão Preto	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5x7z9zf	<NULL>	Individuals 60 years of age or older; Be available to return for revaluations and have a telephone to contact	Presence of uncontrolled moderate to severe hypertension; Presence of cardiac arrhythmias, according to self-report; Hearing Loss; Use of Benzodiazepine; Use of cholinesterase inhibitors; medical diagnosis of Dementia, according to self-report	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-3rxr4bj	Effects of acute supplementation with extract from the bark of the Maritime Pine tree, alone or combined with Yohimbine, on muscle strength, heart and lung capacity during exercise, and blood markers of muscle damage in healthy adults: a randomized, double-blind clinical trial	Recruiting	Intervention	2025-11-06	<NULL>	<NULL>	8492	Effects of acute supplementation with Pinus Pinaster alone or combined with Yohimbine on muscle strength, cardiorespiratory fitness, and muscle damage biomarkers in healthy adults: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-20	União Brasileira de Educação e Assistência	<NULL>	<NULL>	<NULL>	Adult male bodybuilders; age 20 to 45; who have been bodybuilding for at least six months; practitioners who include at least three weightlifting physical activity sessions per week	Individuals diagnosed with any chronic disease or condition such as hypertension ; type 1 or type 2 diabetes mellitus ; as well as those using dietary supplements or medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:10
RBR-6gy3ss	Effects of acute supplementation with Whey Protein and Collagen on the appetite in humans	Data analysis completed	Intervention	2020-02-20	<NULL>	<NULL>	3521	Effects of acute supplementation with Whey Protein and Collagen on the appetite in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6gy3ss	<NULL>	The study population consisted of women with a Body Mass Index (BMI) above 18.5 kg / m2 and less than 25.5 kg / m2 and aged between 18 and 35 years.	Women diagnosed with autoimmune diseases or using immunosuppressive drugs were excluded from the research; with clinical diagnosis of diabetes, thyroid dysfunction, chronic kidney disease or liver disease; who underwent bariatric surgery prior to the research; chronic drinkers; using drugs that alter appetite or body weight (appetite suppressants) in the last twelve months; had attended food restriction programs or were using nutritional supplements in the last twelve months; manifested feverish state in the weeks of the research; failure to follow the protocol stipulated for data collection or refused to carry out any of the proposed evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-4yhbqwk	Effects of adding a online behavioral intervention to exercise therapy and patient education compared to exercise and education delivered online for people with anterior knee pain	Not yet recruiting	Intervention	2021-06-04	<NULL>	<NULL>	5246	Effects of an online program including mindfulness, exercise therapy and patient education compared to online exercise therapy and patient education for people with Patellofemoral Pain: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-05	Universidade Estadual Paulista Júlio de Mesquita Filho Campus Presidente Prudente	Universidade Estadual Paulista Júlio de Mesquita Filho Campus Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-4yhbqwk	<NULL>	Participants who meet the following criteria will be included: (i) age between 18 and 40 years; (ii) previous unilateral knee pain when performing at least two of the following activities: staying seated for a prolonged period, squating, kneeling, running, going up and down stairs, jumping and landing from jumping; (iii) previous knee pain with insidious onset of at least 6 months; (iv) worse self-reported pain in the last month of at least 30 mm on the visual analog scale (VAS) of 100 mm.	Participants who meet the following criteria will not be included in the study: (i) previous self-reported knee pain caused by knee trauma; (ii) history of dislocation or patellar subluxation; (iii) clinical evidence of meniscal injury or ligament instability assessed by a trained physical therapist; (iv) clinical osteoarthritis in any joint of the lower limbs evaluated by a trained physiotherapist according to the EULAR criteria; (v) patellar tendinopathy assessed by a trained physical therapist; and (vi) previous physical therapy for the treatment of DFP (at least 6 months prior to the study) and (vii) answer “yes” on any questions on the PAR-Q physical activity readiness questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-68kh6j	Effects of adding an Electrical Appliance associated with other measures to relieve pain during child labor	Not yet recruiting	Intervention	2020-03-17	<NULL>	<NULL>	4850	Effects of the addition of Transcutaneous Electrical Stimulation to Non-Pharmacological measures of relief during childbirth work: Controlled Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Naiara Toledo Dias	Naiara Toledo Dias	https://ensaiosclinicos.gov.br/rg/RBR-68kh6j	<NULL>	inclusion criteria:  pregnant women in active labor; low-risk pregnancies; women with a gestational age of 37-42 weeks; gestation with a single fetus and this one in the cephalic position.	exclusion criteria will be considered:  having a wound or inflammation in the cutaneous areas of application of the TENS electrodes;  presence of a pacemaker; inability to understand verbal commands.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-4pzsfxw	Effects of adding Gait Retraining to lower limb muscle Strengthening on clinical, functional and kinematic parameters of individuals with knee Arthrosis	Not yet recruiting	Intervention	2023-09-08	<NULL>	<NULL>	6534	Effects of adding Gait Retraining to Lower Limb Muscle Strengthening on clinical, functional and kinematic parameters of individuals with knee Osteoarthritis: a double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-18	Universidade Federal de Juiz de Fora	Programa de Pós-Graduação em Ciências da Reabilitação e Desempenho Físico-Funcional da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4pzsfxw	<NULL>	Reliability test participants: students from the Federal University of Juiz de Fora; age equal to or greater than 18 years; no inflammatory, autoimmune, infectious, or traumatic arthropathies; no history of surgery of any joint of the lower limbs; did not use intra-articular injections in the last 6 months. Participants in the intervention or control groups: individuals aged 50 to 65 years; clinical diagnosis of unilateral and bilateral knee osteoarthritis according to the criteria of the American College of Rheumatology; radiographic severity grade II and III according to Kellgren and Lawrence criteria; able to walk freely for at least 10 minutes without needing an assistive device; no inflammatory, autoimmune, infectious, or traumatic arthropathies; no history of arthroplasty or any other surgery of any joint of the lower limbs; who did not use intra-articular injections in the last 6 months; body mass index less than 30 kg/m2; lack of diagnosis of neurological diseases, whether central or peripheral, and vascular diseases of the lower limbs; controlled blood pressure levels, with resting systemic blood pressure below 160/110 mmHg	Participants who do not have the minimum score on the Mini Mental State Examination test; participants who perform intra-articular or surgical infiltration procedures during the application of the research protocol; those who present cardiovascular decompensations, given by pressure levels higher than 220/105 mmHg during the execution of the exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-7ycfcg	Effects of additional protein consumption on weight, musculature and quality of life of cancer patients	Recruitment completed	Intervention	2019-11-07	<NULL>	<NULL>	3174	Effects of leucine supplementation on nutritional status, sarcopenia and quality of life of cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Jessika Soares	Faculdade de Nutrição	https://ensaiosclinicos.gov.br/rg/RBR-7ycfcg	<NULL>	Diagnosis of cancer of the esophagus, stomach, pancreas or biliary tract, attended at the oncology clinic of the hospital; in exclusive chemotherapy; decrease or deficit in food intake; with nutritional risk, evidence of fat loss and / or muscle mass, not receiving a protein supplement enriched with leucine or other branched-chain amino acids, not participating in any muscle strengthening program that agrees to participate voluntarily.	Patients without nutritional risk; presence of edema; mental disorders; cognitive or walking disability; use of pacemakers or metal parts in the body; with use of enteral therapy and / or total parenteral nutrition; absorptive dysfunctions; obstruction of digestive access and use of protein supplementation prior to study or during recruitment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8kyq7g	Effects of adjunctive Mononitrate, an angin medication, in patients with a Schizophrenia diagnosis.	Recruitment completed	Intervention	2018-02-01	<NULL>	<NULL>	1617	Effects of adjunctive Mononitrate, a nitric oxide donor,  in outpatients with a Schizophrenia diagnosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP	Instituto Nacional de Ciência e Tecnologia  Translacional em Medicina	https://ensaiosclinicos.gov.br/rg/RBR-8kyq7g	<NULL>	Patients of both sexes, age between 18 and 50 years, diagnosis of schizophrenia, in outpatient antipsychotic treatment without modifications in the last month and with symptoms present in the positive or negative dimensions.	Presence of relevant medical condition, such as cardiovascular diseases, severe hypertension, renal failure, liver disease, hypothyroidism, hyponatremia, B12 hypovitaminosis, previous intracranial hypertension, epilepsy, pregnancy, breastfeeding). This also includes patients who have signs and symptoms suggestive of hypotension such as blurred vision, dizziness, pallor, and cold extremities. History of hypersensitivity to organic nitrates. Diagnosis of substance use disorder according to DSM criteria, except nicotine. Patients with severe psychiatric comorbidities and who are the focus of clinical care in the recruitment period, such as major depressive episode and obsessive compulsive disorder. Patients with clinical criteria for integral hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-8c53fhx	Effects of adopting oral care without the use of antiseptics compared to oral hygiene with chlorhexidine on the occurrence of  pneumonia in patients admitted to an intensive care unit	Recruiting	Intervention	2022-07-18	<NULL>	<NULL>	6785	Effects of adopting oral dental care without the use of antiseptics compared to oral hygiene with chlorhexidine on the occurrence of nosocomial pneumonia in patients admitted to an intensive care unit: a pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8c53fhx	<NULL>	Patients aged 18 years or older admitted to the ICU-HU-UFJF during the study period and without evidence of pulmonary infection at admission will be included	Patients who stayed for less than 5 days in the Intensive Care Unit; patients in whom dental evaluation was not possible; immunosuppressed patients; in palliative care; pregnant women and patients who do not consent or whose closest family member does not consent to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-79wnrc	Effects of aerobic and resistance exercise associated with health care therapy of those who want to quit smoking	Recruitment completed	Intervention	2018-05-04	<NULL>	<NULL>	1764	Efficacy of aerobic and resistance training associated with basic cognitive-behavioral therapy in smoking cessation: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-02	Universidade Estadual Paulista - FCT/UNESP	Universidade Estadual Paulista - FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-79wnrc	<NULL>	Smoking at least 10 cigarettes / day; age between 18 and 60 years; clinically stable individuals with no change in medications for at least 30 days	"Known pre-existing chronic cardiorespiratory diseases (arrhythmias, uncontrolled hypertension, chronic cough, chronic bronchitis, pulmonary emphysema or FEV1 / FVC  menor que 70%); individuals with pathological conditions that prevent the performance of physical exercise (orthopedic and / or neurological diseases); use of nicotine replacement drugs and / or antidepressants as an aid in smoking cessation; alcohol abuse; pregnant or intending to become pregnant during the exercise protocol; and systematic exercise, for at least 20
minutes a day, three days a week for six months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-492q8z	Effects of aerobic and resistance exercise training on the heart performance and its relationship to genetic alteration in diabetic patients - randomized controlled clinical trial	Recruitment completed	Intervention	2015-12-02	<NULL>	<NULL>	2332	Combined effects of exercise training on cardiovascular and metabolic performance and its relation to the polymorphism AMPD1 gene in diabetic patients - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-20	Universidade Federal de São Carlos	Conselho Nacional de Desenvolvimento Cientifico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-492q8z	<NULL>	"Volunteers of both genders between 30-65 years;Clinical diagnosis of type 2 diabetes, according to the American Diabetes Association; 
Clinically stable;
Non-practicing physical activity in the last six months, with sort of sedentary, according to the American Heart Association (VO2max: 30.2 ± 4 3 ml/kg/min-1)."	Smokers, elitist, in the presence of any diseases of the respiratory system and skeletal muscle, active inflammatory disease, acute or chronic, and evidence of myocardial ischemia and / or cardiovascular pathologies to clinical and / or exercise test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-6sz5xrz	Effects of aerobic and strength training on health-related aspects compared to cardiovascular risk factors	Recruitment completed	Intervention	2021-03-18	<NULL>	<NULL>	4575	Effects of combined training on morphological, functional, cardiomatabolic and biochemical parameters in individuals with cardiovascular risk factors	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-28	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6sz5xrz	<NULL>	Be a participant in the PROCOR program; have medical authorization for physical exercise; having a risk factor for cardiovascular disease; both genders; age above 18 years	Have musculoskeletal limitations that may impair the performance of the exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-64mpg85	Effects of aerobic exercise associated with systemic laser in women with fibromyalgia	Recruiting	Intervention	2024-10-03	<NULL>	<NULL>	7396	Effects of an aerobic exercise protocol associated with systemic photobiomodulation on cardiorespiratory fitness, fatigue and functional capacity in women with fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Departamento de Biociências -Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-64mpg85	<NULL>	This study will include individuals of female sex; aged between 18 and 60 years; with a diagnosis of FM that will be scheduled by a specialized physician selected by the patient and later confirmed by a physical therapist who holds a doctorate and has eight years of experience in the area of Rheumatology taking into account the FM diagnostic criteria of the American College of Rheumatology Widespread Pain Index WPI greater or equal to 7 and Symptom Severity Scale ESS greater or equal to 5 or WPI of 4 to 6 and ESS score greater or equal to 9 widespread pain defined as pain in at least 4 of the 5 regions jaw symptoms and abdominal pain are not included in the definition of widespread pain and symptoms present for at least 3 months with cognitive capacity to understand the study according to the cut-off score of the Mini-Mental State Examination classified as slightly active and irregularly active according to criteria established by the International Physical Activity Questionnaire administered in its short version have a medical certificate allowing physical activity and interest in participating in the entire experimental protocol	Presence of uncontrolled systemic diseases, such as diabetes mellitus and systemic arterial hypertension; Neurological and musculoskeletal conditions that may directly interfere with the evaluations, such as paralysis, significant changes in sensitivity, advanced joint diseases (such as arthroplasties or osteoarthritis); Individuals who are malnourished (BMI &lt; 18.5 kg/m2) or morbidly obese (BMI ≥ 40 kg/m2); Absolute contraindication for photobiomodulation, such as the presence of neoplasia; Failure to present a medical certificate to perform physical exercise will prevent participation in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-278yfh	Effects of Aerobic Exercise Combined with Strength, done in varied ways, in patients with HIV who have used anti-disease drugs for more than one year and attended at a university hospital: a randomized clinical trial	Recruiting	Intervention	2019-06-26	<NULL>	<NULL>	2786	Effects of a Periodized Combined Exercise Program on HAART patients for more than one year and attended at a university hospital: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-24	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-278yfh	<NULL>	Being a patient infected with HIV and using HAART for more than a year in the Infectious and Parasitic Diseases department of a University Hospital. Be between 18 and 60 years old. Good health condition for the practice of the proposed physical exercises. Being without physical activity or physical exercise for at least six months. Three-times-a-week trip availability for training location. These criteria will be verified by the physicians proposing this research (M Mário León Silva-Vergara and Fernando de Freitas Neves) during routine care.	Participant who presents any clinical complications throughout the intervention. Participant that presents some limitation that could compromise their physical integrity throughout the intervention with physical exercise. Have a diagnosis of opportunistic diseases in the last two years. Have a diagnosis of liver disease and / or nephropathy and / or neuropathy. Have a history of orthopedic surgeries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-7t8vqrz	Effects of Aerobic Exercise with and without Cognitive Tasks on Gait control, Balance, Acetylcholine neurotransmitter Activity, activity of front part of the Brain and Symptoms of people with Parkinson´s disease	Recruiting	Intervention	2022-02-14	<NULL>	<NULL>	5526	Effects of Resistance Training with and without Cognitive tasks on the Automaticity of Gait, Postural Instability, Cholinergic Activity, prefrontal cortex activity and Motor Symptoms Severity of individuals with Parkinson´s disease: A randomized double Blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-15	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7t8vqrz	<NULL>	Parkinson´s disease severity at II-III stage according to the modified Hoen Yahr scale; Age between 50 and 85 years old; Global cognition with a score greater than 21 for individuals with schooling between 4 and 12 years, and greater than 20 for individuals with more than 12 years of schooling, according to the Monttreal Cognitive Assessment (MoCa), portuguese version; and being a faller (i.e., more than 2 falls in the last 6 months)	Not have had training in the last 6 months; No othe neurological disorder (beyond idiopathic Parkinson´s disease; Do not use AChE inhibitors (e.g., rivastigmine, donepezil, galantamine and tacrine), benzodiazepine, neuroleptic or tricyclic antidepressants; Not having resting tremor with a score greater than 2 (i.e., excessive tremor); and not present Freezing of Gait	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7354r6	Effects of Aerobic Training During Heart Rate Hemodialysis in Patients With Chronic Renal Disease	Data analysis completed	Intervention	2018-07-24	<NULL>	<NULL>	2045	Analysis of Heart Rate Variability in Exercise Supervised in Cicloergometry in Patients with Chronic Renal Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-12	Faculdade de Medicina do abc de Santo André.	Faculdade de Medicina do abc de Santo André.	https://ensaiosclinicos.gov.br/rg/RBR-7354r6	<NULL>	Outpatients of both sexes; literate; aged 18 years or over; who were undergoing renal treatment for at least six months	Volunteers who have unstable angina; uncontrolled systolic or diastolic arterial hypertension; use of antiarrhythmics; severe pneumopathies; acute systemic infection; severe renal osteodystrophy; disabling neurological and musculoskeletal disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-4yydrsg	Effects of Aerobic Training performed on stationary bicycle on cognitive function and cerebrovascular blood vessel function in patients with Parkinson&apos;s Disease	Recruiting	Intervention	2024-11-04	<NULL>	<NULL>	7749	Effects of Aerobic Training on cerebrovascular and cognitive functions and gait of patients with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-19	Universidade Nove de Julho	Associação Brasil Parkinson	https://ensaiosclinicos.gov.br/rg/RBR-4yydrsg	<NULL>	Individuals of both sexes having a previous diagnosis of Parkinson&apos;s disease; be undergoing pharmacological treatment for PD; be at least 40 years old	Being in Hoehn &amp; Yahr stages 4 and 5 of Parkinson&apos;s disease; have other neurological diseases in addition to Parkinson&apos;s disease; present a previous diagnosis of cardiovascular disease (except systemic arterial hypertension) or presence of symptoms suggestive of an unknown cardiovascular disease; inability to move independently without the aid of aids; present contraindications for aerobic training; be performing aerobic training regularly; have long COVID; severe cognitive impairment defined by a score lower than 18 on the Mini Mental State Examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-72mvj5	Effects of Alternative Foods on Muscular and Fat Mass of children	Data analysis completed	Intervention	2017-08-08	<NULL>	<NULL>	1324	Nutritional effects of Protein-Energy Fortification of school meals for children in situation of Food Insecurity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-72mvj5	<NULL>	Children aged 6 to 11 enrolled in the 1st, 2nd or 3rd years of elementary school of a public school in the city of Santa Maria - RS - Brazil, and who responded positively to the invitation (written and spoken) to participate in the study; children whose parents or guardians voluntarily signed the Informed Consent Term.	Children with a history of chronic-degenerative diseases (diabetes, liver or kidney disease); children with  edema; children with soy allergy; children who attended classes less than 80% of the days used for intervention in phase II of the study; children who missed any of the nutritional assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-7hkhthq	Effects of aminoacid supplementation after resistante exercise	Recruitment completed	Intervention	2026-02-11	<NULL>	<NULL>	8861	Effect of Supplementation with an essential Amino Acid blend enriched with Leucine on the Immune System after resistance exercise: a prospective randomized, double-blind, placebo-controlled study in female gym exercise	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-15	Universidade Federal de São Paulo (UNIFESP) - Hospital São Paulo - Hospital Universitário da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	women aged between 18 and 49 years old, who practice resistance exercise, at least three times a week, for at least one year for one hour/day.	participants who were unable to complete the testing protocol, those who did not adhere to the program, or were injured during the study. women that don´t have between 18 and 49 years old	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-9vr6jyf	Effects of an accessible, low-cost, and individualized physical exercise program on the mobility of people with Mucopolysaccharidosis	Data analysis completed	Intervention	2026-02-26	<NULL>	<NULL>	8899	Impact of an accessible, low-cost, and individualized fhysical rehabilitation program on the functional capacity of patients with Mucopolysaccharidosis	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-05	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Individuals with a confirmed diagnosis of Mucopolysaccharidosis (any type) by enzyme assay and/or genotyping; of both sexes; over six years of age; whose guardians signed the informed consent form; under follow-up at the Reference Center for Inborn Errors of Metabolism; and without participation in physical rehabilitation or regular aerobic exercise (greater than 150 minutes/week) in the last six months	Patients unable to walk; with tracheostomies and/or dependent on invasive mechanical ventilation; hospitalized for acute respiratory infection less than 30 days prior to assessment; with severe heart disease; with cognitive impairment, unable to understand verbal instructions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:56
RBR-6qk24v7	Effects of an acupuncture protocol associated with physical exercise for chronic back pain and functional independence in the elderly.	Recruitment completed	Intervention	2022-07-28	<NULL>	<NULL>	5515	Effects of an acupuncture protocol associated with multicomponent physical exercise on chronic low back pain and functional independence in the elderly: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-15	Universidade Comunitaria da Regiao de Chapeco - UNOCHAPECO	Universidade Comunitaria da Regiao de Chapeco - UNOCHAPECO	https://ensaiosclinicos.gov.br/rg/RBR-6qk24v7	<NULL>	elderly, of both sexes, with preserved cognitive status tested by the MMSE. Age between 60 and 85 years. Presence of Chronic Low Back Pain, defined as a complaint of pain in the lumbar region below the 12th thoracic vertebra, with or without radiation, and lasting more than 6 months, with a moderate to severe degree of intensity, tested by the Visual Analogue Pain Scale.	missing two consecutive intervention sessions or three interspersed. underwent acupuncture treatment in the last 6 months. present injuries or neurological disorders that compromise walking and exercise performance. have tumors and are undergoing cancer treatment; have nerve compression caused by spinal pathologies, trauma or tumors; have bone or spinal cord infections and ankylosing spondylitis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7fqxkpp	Effects of an Application on the Knowledge of nursing students interventions	Not yet recruiting	Intervention	2022-12-28	<NULL>	<NULL>	5782	The effectiveness of using a Mobile Application in the knowledge of nursing students about the Health of the Elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Faculdade de Ceilândia da Universidade de Brasília	Fundação Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7fqxkpp	<NULL>	Being a student regularly enrolled in the nursing course; being in the 9th or 10th-degree semester; having a cell phone with internet to access the app; showing availability to participate in the research; being available to participate in the meetings.	Students who have any impediment (personal, emotional, and others) the use of the app; do not have a mobile device with the Android or IOS operating system; express unfamiliarity with digital technology; tahose who did not complete the research stages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-6vkcb7	Effects of an Educational Action on Knowledge and the Cardiovascular Health Behavior of Men Metallurgical	Data analysis completed	Intervention	2015-07-13	<NULL>	<NULL>	542	Evaluation of an educational program on injury prevention cardiovascular diseases on human health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-11-18	Universidade Estadual de Maringá	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-6vkcb7	<NULL>	135 metallurgical workers were evaluated and the inclusion criteria for the evaluation are: being male; be aged between 18 and 70 years; being actively working on a metallurgical company selected in Metropolitan area of maringá-PR	Being out of the company and/or vacation during the recruitment period;refuse to participate in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-2y2zgy	Effects of an educational activity on adolescent knowledge, attitude and practice regarding cervical Cancer prevention	Recruitment completed	Intervention	2019-09-10	<NULL>	<NULL>	2931	Effects of an educational intervention on adolescent knowledge, attitude and practice regarding cervical Cancer prevention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal do Ceará - UFC	Universidade Federal do Ceará - UFC	https://ensaiosclinicos.gov.br/rg/RBR-2y2zgy	<NULL>	Adolescent; women; age between 13 and 19 years old; regularly enrolled in school	Have a disability that compromises the responses of the adolescents during the research and the involvement of the educational activity, as well as participation in social intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-8rwyp5g	Effects of an educational intervention aimed at Community Health Agents (CHA) about rights in maternal and child health	Data analysis completed	Intervention	2024-10-03	<NULL>	<NULL>	7400	Involving Users to Improve the Quality of Services and Guarantee Rights: strengthening the maternal and child health care system in the first 1000 days in Brazil (I WANT)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-11	Hospital Universitário da Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8rwyp5g	<NULL>	Healthy volunteers. Both genders. At least 18 years old. Be a Primary Health Care professional in the municipalities of selection. Be a support network for pregnant women, women who have recently given birth and/or mothers of 2-year-old children. Be pregnant, have recently given birth and/or the mother of a 2-year-old child	Primary Health Care professionals who were on vacation, on leave and/or away for any reason. Pregnant women, puerperal women and/or mothers of children up to two years old who refused to participate voluntarily	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-3p52g2p	Effects of an Educational Intervention to change the lifestyle of people at risk for diabetes	Recruitment completed	Intervention	2025-04-29	<NULL>	<NULL>	7970	Effects of an Educational Intervention on anthropometric, biochemical, dietary and lifestyle parameters in individuals at high risk for type 2 Diabetes Melitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-20	Universidade Federal de Pernambuco (UFPE)	Universidade Federal de Pernambuco (UFPE)	https://ensaiosclinicos.gov.br/rg/RBR-3p52g2p	<NULL>	Individuals ≥ 20 years and &lt; 60 years; Not having a previous diagnosis of type 1 or type 2 DM; Displaying a body mass index (BMI) ≥ 25 and ≤ 34.9 kg/m², that is, overweight and grade 1 obesity; Having access to a WhatsApp application; Having access to the internet and a personal cell phone; Having a diagnosis of pre-diabetes or gestational diabetes (past) or a score equal to or greater than five in the Diabetes Risk Screening proposed by the American Diabetes Association – ADA	Pregnant women; People with diabetes mellitus, of any type; Unable to practice physical activity, as per medical advice; People with serious neurological or psychiatric problems; People with neoplasms, chronic transmissible diseases, liver or kidney failure, untreated thyroid dysfunction, congestive heart failure and coronary artery disease; Use of anti-obesity medication and/or oral antidiabetic medication; protein supplementation and use of hormone therapy; Have participated in a concomitant weight control program or a medically prescribed diet; Have undergone bariatric surgery in the last three years, or are planning to undergo surgery in the next 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-35mh62v	Effects of an eight-week Adapted Cultivating Emotional Balance Training (ACEBT) on mental health symptoms, brain activity and heart rate variability in university students	Recruitment completed	Intervention	2026-03-06	<NULL>	<NULL>	8953	Effects of an eight-week Adapted Cultivating Emotional Balance Training (ACEBT) on mental health symptoms, brain activity and heart rate variability in university students: a randomized controlled crossover trial assessed with functional magnetic resonance imaging	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-11	Sociedade Beneficente Israelita Brasileira Albert Einstein	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; any gender; be able to participate in all stages of the study	Present contraindication for performing magnetic resonance imaging (according to a standardized questionnaire from the imaging department of this institution); current diagnosis of psychiatric disorder or neurological disease reported by the participant	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-5xh3ch	Effects of an elastic tape on the activity, strength and muscular endurance of subjects with low back pain	Recruitment completed	Intervention	2017-08-02	<NULL>	<NULL>	1313	Effects of kinesio taping on electromyographic activity, muscle strength and endurance in subjects with low back pain: a clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-10	Universidade Estadual de Goiás	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5xh3ch	<NULL>	Age between 18 and 45 years; presence of chronic nonspecific low back pain (low back pain with no specific cause lasting more than 3 months) and authorization of evaluation; procedures through the Free and Informed Consent Form in accordance with resolution 466/12 Of the National Health Council.	History of allergy to the tape (allergy test; episode of exacerbation (pain intensity greater than 05 points on the Visual Analogue Pain Scale (VAS);moderate or severe functional disability according to the Rolland Morris Disability Questionnaire on the days of assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-5d963p8	Effects of an electrotherapeutic modality on knee flexion movement in individuals with spastic cerebral palsy: pilot study	Terminated	Intervention	2022-03-17	<NULL>	<NULL>	5287	Effect of extracorporeal shockwave therapy on knee flexion in individuals with spastic cerebral palsy: pilot study	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2019-12-02	Universidade Estadual Paulistana	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5d963p8	<NULL>	Ability to voluntarily perform knee extension, obtain grade II and grade III spasticity classification of the knee flexor muscles according to the modified Ashworth scale.	Unable to reach the atopic position even with the help of the therapist or auxiliary device, a process performed in any of the lower limbs in the last six months and an intellectual disability that interferes with the understanding of the procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-9bnx9m	Effects of an Exercise  Physical Program in muscle strength, cardiorespiratory fitness, cardiovascular risk and quality of life of elderly.	Recruitment completed	Intervention	2015-07-27	<NULL>	<NULL>	560	Effects of a Concurrent Training program in muscle strength, cardiorespiratory fitness, cardiovascular risk and quality of life of elderly: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-23	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9bnx9m	<NULL>	Should participate 64 elderly with hypertension and diabetes mellitus; aged between 60 and 79 years; of both genders.	Seniors in use of injectable medications and insulin estaminas; uncontrolled hypertension; smokers or former smokers with cessation of tobacco less than 20 years; neurological diseases; symptomatic musculoskeletal disorders, severe obesity; malnutrition; severe kidney disease; recent history of carcinoma; heart disease than high blood pressure; lung disease; changes in cognitive behavior; physically active high intensity;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-8tmrjvn	Effects of an exercise program associated or not with an electrical current in patients with chronic low back pain	Recruiting	Intervention	2022-02-24	<NULL>	<NULL>	7105	Effects of adding transcutaneous electrical nerve stimulation (TENS) during a walking program for individuals with chronic low back pain: blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-10	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8tmrjvn	<NULL>	Individuals of both sexes, aged between 30 and 59 years, with a report of low back pain for more than 3 months, in addition to a minimum score of 3 points on the END and 37 points on the Tampa Scale of Kinesiophobia (ETC).	Regular practice in the last 6 months of any physical exercise program or sport; individuals with a history of fracture or surgical procedure in the lumbar spine; diagnosis of herniated disc with neurological repercussions; having undergone physical therapy treatment in the last month or previously with electrotherapeutic currents; use of analgesics, anti-inflammatory drugs or muscle relaxants in the last week; cancer diagnosis; pregnancy; presence of severe cardiovascular dysfunctions; medical diagnosis of fibromyalgia or other chronic pain in the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-8dpxgcf	Effects of an exercise program for balance in elderly	Recruiting	Intervention	2022-07-15	<NULL>	<NULL>	5487	Effects of an exercise program on static and dynamic stability in elderly	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2022-02-01	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-8dpxgcf	<NULL>	Individuals of both genders; Aged 60 years or older; Ability to walk 10 meters, with or without the use of an auxiliary device; Residents of the city of Rio de Janeiro	Individuals who score ≤18 on the Mini Mental State Examination; Individuals with neurological or orthopedic conditions that limit the performance of their activities of daily living; Individuals who have any uncontrolled cardiovascular, pulmonary or metabolic diseases, or any other health condition that may interfere with the safe conduct of the study exercise protocol; Individuals with amputations and/or prostheses in the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-6ck4gv	Effects of an exercise program in patients with sequelae of stroke	data analysis completed	Intervention	2012-07-09	<NULL>	<NULL>	111	Effects of Square Stepping Exercise in patients with sequelae of stroke	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp	Centro Universitário Hermínio Ometto - uniararas	https://ensaiosclinicos.gov.br/rg/RBR-6ck4gv	<NULL>	Age 50 to 80 years, unilateral cerebrovascular lesions, and only 12 months before the start of the intervention, supported by computed tomography or magnetic resonance imaging of the brain, ability to understand verbal instructions and ability to walk without assistance or with prosthetic or orthoses (canes, crutches)	Orthopedic and neurological disorders prior stroke and clinical instability associated with severe systemic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-5ndvwr	Effects of an Exercise Program on the Cardiovascular System and Physical Endurance of Chronic Renal patients undergoing hemodialysis.	Not yet recruiting	Intervention	2018-11-09	<NULL>	<NULL>	2327	Effects of a Resistance Exercise Program on the Autonomic Cardiovascular Function and without Physical Conditioning of Chronic Renal patients under hemodialysis treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-10	Hospital Universitário da Universidade Federal do Maranhão	Clínica de Rim e Hipertensão Arterial	https://ensaiosclinicos.gov.br/rg/RBR-5ndvwr	<NULL>	Age greater than 18 years; both genders; undergoing hemodialysis for more than 3 months; who have the cognitive ability to understand the research process and sign the informed consent form; volunteer to participate in the study.	Patients with diseases or some type of musculoskeletal disability; bone or joint disorders that make evaluations and exercise protocol impossible; dialysis by catheter in the femoral artery or catheter in the jugular vein; neurological and behavioral changes that in some way render the protocol inapplicable; patients with severe cardiovascular disease; patients presenting hematocrit less than or equal to 30% and / or hemoglobin less than or equal to 10g / D; patients with untreated mitral or aortic insufficiency / stenosis; severe pulmonary conditions; pathologies that incapacitate the study (amputation of upper limbs or lower limbs, amaurosis, deep venous thrombosis); patients who already had resistance exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-5pdk45	Effects of an exercise program on the realignment of lower limbs of overweight and obese children: a randomized clinical trial	Data analysis completed	Intervention	2018-12-13	<NULL>	<NULL>	2385	Realignment of lower limbs in overweight and obese children: an eight week intervention program	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-5pdk45	<NULL>	Being overweight or obese; having between 7 and 9 years of age; returning the Free Consent Form signed by an adult; returning the Assent Form signed; being a student of the José Joaquim da Silva School.	Being present in less than 85% of the sessions; participating in sports activities other than Physical Education classes; being transfered from the school; refusing to perform the exercises in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-8w35rx	Effects of an exercise protocol in standing over sedentary lifestyle of frail elderly	Recruiting	Intervention	2018-10-02	<NULL>	<NULL>	2256	Effects of an exercise protocol in orthostatism over sedentary behavior of frail elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	https://ensaiosclinicos.gov.br/rg/RBR-8w35rx	<NULL>	Elderly over 60 years; diagnosis of Fragility evidenced by the presence of at least 3 of the 5 criteria: weight loss will be considered for unintentional loss greater than 4Kg in the last year or 5% of body weight, fatigue, physical inactivity, muscle weakness and slow gait; difficulty in mobility; non-participation in other exercise programs; acceptance in signing the trial Consent Form.	Inability to stay standing; impossibility to perform the exercise due to any type of clinical change or adverse effects such as pain, cardiorespiratory, orthopedic, mental or neurological changes; elderly with increased risk for falls without family or professional follow-up of a caregiver for the practice of home exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-103nyv5v	Effects of an Exercise session performed on stationary bicycle on cognitive function and cerebral blood vessel function in patients with Parkinson&apos;s disease	Recruiting	Intervention	2023-01-25	<NULL>	<NULL>	5843	"Aerobic Exercise effects on cognitive and cerebrovascular functions on patients with
Parkinson Disease"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade Nove de Julho	Associação Brasil Parkinson	https://ensaiosclinicos.gov.br/rg/RBR-103nyv5v	<NULL>	previous diagnosis of Parkinson&apos;s Disease; being undergoing pharmacological treatment for Parkinson&apos;s Disease; be at least 50 years old	being in Hoehn &amp; Yahr stages 4 or 5 of Parkinson&apos;s Disease; presenting other neurological diseases in addition to Parkinson&apos;s disease; present electrocardiographic alterations during exercise test suggestive of cardiovascular pathology; having a diagnosis of cardiovascular disease, cancer, or any type of dementia; score ≤ 20 on the “Montreal Cognitive Assessment (MoCA)”; be performing aerobic training regularly; have musculoskeletal problems that interfere with performing aerobic exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-458tbcd	Effects of an intervention based on Eating with Full Attention in patients who underwent Stomach Reduction Surgery and regained weight: a randomized clinical trial	Not yet recruiting	Intervention	2021-03-05	<NULL>	<NULL>	4566	Effects of the Mindfulness-Based Food Awareness Training intervention (Mindfulness-Based Eating Awareness Training - MB-EAT) in patients after Bariatric Surgery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-458tbcd	<NULL>	Present weight regain after bariatric surgery; bariatric surgery was performed in the last five years (minimum 2 years after surgery), reported binge eating episodes and accepted to participate in the study. Weight gain will be considered for participants who recover 50% of the lost weight achieved in the long term or recovery of 20% of the weight associated with the reappearance of comorbidities (SBCBM, 2015). Binge eating episodes are those participants who meet the criteria established by DSM-V (2014): Eating within a limited period of time (for example, within a period of 2 hours), a quantity of food definitely greater than most people would consume at a similar time, under similar circumstances and feeling of lack of control over the episode (a feeling of not being able to stop or control what or how much one eats)	Current diet for weight loss or use of medications that can affect weight; pregnancy; breast-feeding; presence of psychiatric disorders; personality disorders; severe depression; alcohol abuse and / or being on psychiatric drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-74nhx9	Effects of an Intervention involving exercises for the entire lower limb in athletes with knee pain caused by Patellar Tendinopathy	Not yet recruiting	Intervention	2019-12-10	<NULL>	<NULL>	5209	Effects of an intervention addressing kinetic chain factors in athletes with Patellar Tendinopathy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-74nhx9	<NULL>	Inclusion criteria for this study will be: male athletes between 15 and 40 years old;  Practice physical activities involving high demand for the knee extensor mechanism (volleyball, basketball, handball, soccer, running, etc.) for at least 2 times a week; Present with pain localized in the apex of the patella, patellar tendon or its insertion in the tibial tuberosity, confirmed by palpation; Present with pain during activities that impose load on the patellar tendon (jumping, squatting, etc.) for more than 3 months; Present with pain in the patellar tendon during the single-leg decline squat test; Score less than 88 points on the Victorian Institute of Sport Assessment - Patella (VISA-P) questionnaire.	Athletes will be excluded from the study if they: have been using or have used corticosteroid medication in the last 6 months; Have symptoms related to trauma or who have had knee surgery; have knee symptoms associated with other dysfunctions, such as patellofemoral pain, intra-articular injuries, patellar instability, and Osgood-Schlatter or Sinding-Larsen-Johansson disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-7nyhhj	Effects of an intervention involving physiotherapy and physical education, performed for all ages, aimed at the physical capacity of the elderly living in the community	Recruitment completed	Intervention	2016-10-26	<NULL>	<NULL>	1058	Effects of interdisciplinary and intergenerational intervention in the community elderly mobility	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-25	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7nyhhj	<NULL>	People with 60 years or more; both sexes; without health changes to indicate the practice of physical exercises	People who do not adhere to the program and present more than three fouls	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-5ddt474	Effects of an intervention program in patients with swallowing difficulties and Parkinson&apos;s	Recruiting	Intervention	2023-11-17	<NULL>	<NULL>	6582	Effects of an intervention program in dysphagic patients with dysphagia Parkinson&apos;s	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-5ddt474	<NULL>	Adults treated at the Hospital Universitário Onofre Lopes (HUOL); aged &gt;18 years; of both genders; diagnosed with Parkinson&apos;s; complaining of oropharyngeal dysphagia; who had not previously undergone speech therapy	Patients with coexistence of other neurological diseases; with head and neck cancer; tracheostomy users; using an alternative feeding route; those who are unable to follow commands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-6s3bncq	Effects of an intuitive eating-based intervention on behavioral and metabolic responses in overweight and obese adults: a randomized clinical trial pilot study	Recruitment completed	Intervention	2023-05-16	<NULL>	<NULL>	6084	Intervention based on the intuitive eating technique under nutritional counseling: metabolic and behavioral responses in overweight and obese adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6s3bncq	<NULL>	male and female volunteers; between 18 and 59 years old; with a BMI above 25 Kg/m2	pregnant; puerperal women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-78nwbg	Effects of an online social network on promoting and supporting breastfeeding	Data analysis completed	Intervention	2016-12-27	<NULL>	<NULL>	2569	Effects of an intervention to promote and support for breastfeeding through social maternal online network	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-08	Hospital Universitário Lauro Wanderley	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-78nwbg	<NULL>	Mothers in the postpartum period that use the online social network Facebook; can read and write.	Illiterate mothers; under the age of 18;  seropositive for HIV or other diseases that contraindication to breastfeeding; premature fetuses; low weight; twin; congenital problems to prevent suckling at the breast.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-25v5wjf	Effects of Andiroba Extract Oil on the Gingival Inflammaton	Recruitment completed	Intervention	2026-01-06	<NULL>	<NULL>	8703	Effect of Carapa guianensis Extract Gel on Dental Plaque (periodontopathogenic microorganisms) and Gingival Inflammation in patients undergoing fixed orthodontic treatment: a prospective split-mouth study	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Federal do Pará	<NULL>	<NULL>	<NULL>	Age between 12 and 17 years; both sexes; Must sign the research information letter and Informed Consent Form; must not have systemic alterations; normal cognitive and motor development; index teeth present: 13, 14, 15, 23, 24 and 25; must have class I malocclusion: crowding of anterior teeth, no crossbites and with coronal exposure for bonding of braces	Antibiotic treatment within 1 month prior to the evaluation; use of any medications that may affect gingival tissue; systemic diseases or conditions that may interfere with the study results (immunodeficiency, uncontrolled diabetes, hematological diseases, genetic conditions, deficiencies); presence of orthopedic orthodontic appliances and/or space maintainers; mucosal diseases; severe oropharyngeal infections; extensive caries in any tooth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-26cq7n	Effects of antioxidant supplementation Coenzyme Q10 in women with Metabolic Syndrome and liver fat	Recruiting	Intervention	2018-06-21	<NULL>	<NULL>	1921	Effects of Coenzyme Q10 suplementation in women with Metabolic Syndrome and hepatic steatosis: double-blind controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-12	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-26cq7n	<NULL>	women; age between 20 and 55 years; sedentary; not menopausal; Body mass index less than 40 kg / m2; carrier of Metabolic Syndrome; with hepatic steatosis.	current gestation / lactation; smoking; alcoholism; inflammatory rheumatologic, intestinal and hepatic diseases; confirmed cancer; polycystic ovary syndrome; confirmed diabetes mellitus (type 1 or 2); refractory arterial hypertension; thyroid disease; use of Ginkgo biloba and statins; Supplementation with vitamin E or CoQ10 in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-35442h	Effects of aquatic exercise in functional activities in Parkinson&apos;s Disease	Recruitment completed	Intervention	2016-04-04	<NULL>	<NULL>	781	"Analysis of the effects of a aquatic exercise program in functionalactivities
 and posture of subjects with Parkinson&apos;s disease"	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-35442h	<NULL>	Both genres. Clinical diagnosis of idiopathic Parkinson Disease. Stages 1-4 in the Hoehn and Yahr scale. Clinical Certificate for aquatic physical activity and to attend heated pool.	Not having independent gait related or unrelated to Parkinsons Disease. Another disease that could interfere with the physical assessments such as changes in the balance of vestibular. Visual or auditory sensory deficit that prevented follow verbal and visual instructions. Contraindications to attend heated pool, such as fever, incontinence, severe change in blood pressure, open wound. Change in the parameters of drug intake based on L-dopa during the study period. Do not agree with the TCLE. Present change in drug prescription during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-8btc25	Effects of Aquatic Exercise on cardiovascular risk factors and cardiac autonomic modulation of postmenopausal women with Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2018-02-27	<NULL>	<NULL>	1661	Effect of Aquatic Exercise on the autonomic modulation of the heart rate of postmenopausal women with Diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-15	Universidade de Marília	Universidade Estadual Paulista - Faculdade de Filosofia e Ciência - Campus Marília	https://ensaiosclinicos.gov.br/rg/RBR-8btc25	<NULL>	Being a woman between the ages of 50 and 85 years; amenorrhea for at least 12 months (postmenopausal state); not having performed systematic exercise in the last 3 months; presenting a diagnosis of type 2 diabetes mellitus for at least 3 years.	Inability to enter and exit pool independent; inability to understand and attend simple verbal command; amputations and / or prosthesis use in limbs; sequelae of stroke; Parkinson&apos;s disease; fractures in lower limbs and / or spine after age 60; incapacitating labyrinth; otitis; hydrophobicity; skin lesions; deformity of the feet. criteria of non-inclusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-8rtpfqx	Effects of aquatic exercise on the function of patients with amputation	Recruiting	Intervention	2022-06-22	<NULL>	<NULL>	5437	Influence of aquatic exercise on functionality, pain and postural balance in amputees: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-03	Associação de Pais e Amigos dos Excepcionais	Fundação Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8rtpfqx	<NULL>	Volunteer adults; aged 18 to 60 years; with unilateral lower limb amputation; transtibial or transfemoral; both genders; who are able to follow verbal commands; clinically stable	Neurological disorders; circulatory disorders; uncontrolled diabetes; patients on psychiatric medication; patients with infectious; contagious dermatological lesions; BMI ≥ 30	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-93qtv5	Effects of aquatic exercises in trunk control and their interference in gait of subjects with cerebral palsy	Recruitment completed	Intervention	2015-04-06	<NULL>	<NULL>	434	Effects of aquatic exercises in trunk control and their interference in gait of subjects with cerebral palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-20	Hospital e Centro de Reabilitação da AACD	Hospital e Centro de Reabilitação da AACD	https://ensaiosclinicos.gov.br/rg/RBR-93qtv5	<NULL>	Clinical diagnosis of spastic diparesis type of Cerebral Palsy; level II or III to the Gross Motor Function Classification System (GMFCS); aged 6 years to 15 years and 11 months.	Uncooperative patients; unable to understand the proposed activities; undergoing orthopedic surgery less than 12 months ago; undergoing peripheral blocks less than six months ago.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-2f3fvr	Effects of Aquatic Exercises on the heart in Overweight adults	Recruiting	Intervention	2018-01-11	<NULL>	<NULL>	1562	Effects of Deep Water Running on the cardiac autonomic control and functional capacity in adults with Overweight and Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-2f3fvr	<NULL>	Participants of both genders; adults ranging from 39 to 59 years of age; with overweight or obesity I.	Volunteers with cardiorespiratory, musculoskeletal or neuromuscular diseases that impede the performance of the aquatic training program; hydrophobia; skin wounds; and infectious-contagious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-99b6jr6	Effects of Aquatic High-intensity Interval Training on physical fitness, lipid profile and glycemic control in the middle-aged and elderly adults	Recruiting	Intervention	2021-10-10	<NULL>	<NULL>	4962	Effects of Aquatic High-intensity Interval Training on cardiovascular risk, physical conditioning and motor function	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-22	Centro Universitário FMABC	Faculdade Integradas de Patos-FIP	https://ensaiosclinicos.gov.br/rg/RBR-99b6jr6	<NULL>	Volunteers participating in the Vida Ativa extension project at Centro Universitário UNIFIP; who perform aquatic exercise activities; present regular frequency; are aged between 45 to 80 years; who passed underwent blood tests, urine and electrocardiogram; who underwent medical evaluation to perform physical exercises.	"Individuals with limitations to perform the initial and final assessment tests;  some of the limitations are walking with difficulty, to use orthoses to walk, sequelae of stroke, advanced osteoarthrosis, situations which prevented them from performing the exercise test; use of metal prosthesis or pacemaker that limited the bioimpedance test.
Those who had less than 75% of presence in weekly activities, some infection during the study, or who were unable to complete both assessments (initial and final) were discontinued."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-3hp5yvh	Effects of aquatic physical exercises in healthy adults and elderly people with Parkinson&apos;s disease	Recruiting	Intervention	2023-06-20	<NULL>	<NULL>	6161	Effects of an Aquatic Physical Exercise Program (APEP) on motor, non-motor and cardiorespiratory aspects in healthy adults and elderly people with Parkinson&apos;s Disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3hp5yvh	<NULL>	Healthy elderly; people with a clinical diagnosis of idiopathic Parkinson&apos;s disease; both sexes; between stages 1 and 4 of the Modified Hoehn and Yahr Scale; continuous use of dopaminergic medication; with a clinical certificate of physical fitness to attend a heated pool	People in wheelchairs; whether or not due to Parkinson&apos;s disease; cognitive changes; visual changes; hearing changes; history of cardiovascular surgeries; absolute contraindications to use a heated pool	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-2kwqfx	Effects of aquatic physical therapy on pain and sleep in preterm newborns admitted to a neonatal intensive care unit	Recruitment completed	Intervention	2016-12-19	<NULL>	<NULL>	1104	Effects of aquatic physical therapy on pain and sleep and wakefulness in patients admitted to a neonatal intensive care unit: a quasi-experimental clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2kwqfx	<NULL>	Preterm newborns; Corrected gestational age of 30 to 37 weeks; Clinically stable; Signed by the parents or guardians at the end of free and informed consent.	Patients using invasive mechanical ventilation; Patients on noninvasive mechanical ventilation; Clinically unstable; With recent surgeries; Central and / or peripheral venipuncture in places that prevent immersion in water	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-6nj4mk	Effects of Aquatic Physiotherapy on Epigenetic, Inflammatory and Neutotrophic factors in Parkinson&apos;s disease patients	Data analysis completed	Intervention	2019-12-10	<NULL>	<NULL>	3266	Effects of an Aquatic Physical Activity program on clinical-functional parameters, peripheral modulation of epigenetic mechanisms, inflammatory markers, and Brain Derived Neurotrophic Factor (BNDF) levels in individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-6nj4mk	<NULL>	As inclusion criteria for both control and exercise groups, subjects should present Parkinson Disease diagnosed by a neurologist (rule out parkinsonisms with other causes). In addition, they must be able to participate in the proposed physical activity program and sign the consent form. The participants need to be between 50 and 80 years old.	As exclusion criteria for both CONTROL AND EXERCISE groups, the individual should present characteristics of cognitive deficits verified through the application of the MoCa Questionnaire. Specifically for the EXERCISE group, as exclusion criteria, aspects such as the inability to participate in aquatic physiotherapy will be adopted, besides the individual presenting other diagnosed neurological and orthopedic pathologies that preclude their participation in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-5btyvr	Effects of Aquatic Physiotherapy on the function, quality of life and risk of falls in the elderly in Curitiba	Data analysis completed	Intervention	2019-07-05	<NULL>	<NULL>	2804	Effects of Aquatic Physiotherapy on functional capacity, quality of life and risk of falls in the elderly in Curitiba	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-25	Faculdade Dom Bosco	Secretaria Municipal de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-5btyvr	<NULL>	Elderly aged 60 years or over; being on the waiting list for hydrotherapy at the Pardinho Ombudsman&apos;s Physical Activity Center	Elderly people with urinary or fecal incontinence will be excluded; open wounds; infectious cutaneous diseases; infectious diseases; uncontrolled blood pressure; recent postoperative period; cognitive alteration that prevents completion of the questionnaire; participation in another program of physical activity or physiotherapeutic rehabilitation; elderly with severe neurological and cardiac problems; or any other clinical problem that would contraindicate the performance of the tests and exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-2grxdz7	Effects of Aquatic Physiotherapy on the health and quality of life of elderly people in the community	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9042	Effects of Aquatic Physiotherapy on functionality, fear of falling, pain, well-being, and quality of life of community-dwelling elderly	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-11	Universidade Estadual de Goiás	<NULL>	<NULL>	<NULL>	People aged 60 or older; of both sexes; who are able to walk with or without the aid of walking aids	Older adults with severe cognitive impairment that precludes the use of assessment tools; older adults with contraindications to immersion in a therapeutic pool (uncontrolled blood pressure, severe heart failure, severe kidney disease, fever, recent surgery, uncontrolled epilepsy, low vital capacity, and deep vein thrombosis); or those who are clinically unstable at the time of assessment or intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-8rkwnw	Effects of Arginine Supplementation associated with an Exercise Training Program in Chronic Obstructive Pulmonary Disease	Not yet recruiting	Intervention	2019-01-22	<NULL>	<NULL>	2453	Effects of Arginine Supplementation associated with Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-31	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8rkwnw	<NULL>	Patients with moderate to very severe chronic obstructive pulmonary disease; with age equal to or greater than 40 years; of both sexes.	Current smoking; presence of associated diseases that make it impossible to carry out any of the study evaluations or limit the progression of training such as osteoarthritis, severe cardiovascular and neurological conditions and non-signing of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-86ksrj	Effects of Aromatherapy on labor: A triple blind randomized clinical trial	Data analysis completed	Intervention	2020-07-03	<NULL>	<NULL>	3973	The use of aromatherapy in humanized labor	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2018-12-05	universidade federal do piaui	universidade federal do piaui	https://ensaiosclinicos.gov.br/rg/RBR-86ksrj	<NULL>	Pregnant women in active labor; of age; term pregnancy; In spontaneous labor; live fetus, fetus with cephalic apex presentation, fetus with good vitality conditions.	Pregnant women in latent labor; pregnant women who had an indication for cesarean delivery at admission; pregnant women who had clinical complications; pregnant women with changes in amniotic fluid and presence of fetal malformation; pregnant women in labor induction or with indication for uterotonic use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-6rrc63n	Effects of Aromatherapy on women with climacteric symptoms	Not yet recruiting	Intervention	2024-02-14	<NULL>	<NULL>	6783	Effects of Aromatherapy with Lippia alba (Mill.) N.E. Brown essential oil on climacteric symptoms: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Susy Maria Feitosa de Melo Rabelo	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6rrc63n	<NULL>	Interest in participating in the study; age between 40 and 65 years; presence of one or more climacteric symptoms, reported from the Blatt and Kupperman Menopausal Index and with moderate to intense intensity; Menopause occurred no more than 5 years ago; Preserved cognitive function, assessed using the Mini Mental State Examination.	Women who have any speech articulation or hearing problems that prevent them from responding to the research instruments and participating in the intervention; Presence of dermatological lesions or considerable deformities in the nose, in addition to already recognized anosmia; Women who have undergone aromatherapy treatment or other PICS in the last month; Women using anxiolytic substances in the last month, such as: benzodiazepines, antihistamines, hypnotics, sedatives, antidepressants, antipsychotics, stimulants and corticosteroids; Women using hormone replacement therapy (HRT) in the last 3 months prior to the intervention; Previous clinical diagnosis of chronic diseases, such as: diabetes mellitus, systemic arterial hypertension, cardiovascular diseases, cancer, seizures, epilepsy and so on, decompensated; Women using antithrombotic medication, as drug interactions with Lippia alba are known; Recognized hypersensitivity after using Lippia alba in other formulations (teas, infusions, creams, lotions, shampoos, etc.); Users of Lippia alba essential oil.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-94bszgk	Effects of association of an intensive motor training and brain stimulation on gait, balance and legs movement of people who suffered a stroke	Not yet recruiting	Intervention	2023-06-06	<NULL>	<NULL>	6139	Association of Lower Extremities - Constraint Induced Movement Therapy (LE-CIMT) and Transcranial Direct Current Stimulation (tDCS) on functionality and performance of lower limbs, gait and balance of post-stroke patients ¿ Triple-blinded, controled, randomized Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-03	Associação de Assistência a Criança com Deficiência	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94bszgk	<NULL>	Medical diagnosis of a single Stroke with more than six months of injury; both genders; minimum age of 18 years old and maximum age of 79; clinically stable; presenting hemiparesis as a sequel to the stroke; present a gait deficit caused by the sequelae of the stroke, classified at Level 3 to 5 of the Functional Ambulation Classification; go from sitting to standing independently even with the help of upper limbs; not having undergone orthopedic surgery in the last 6 months or chemical blockade in the last 3 months prior to the beginning of the study; no history of seizures; without anticonvulsant medication	Not tolerate the electrical stimulation; lesions in the scalp region where there will be electrode contact; to present convulsive episode during the protocol; epileptic Focus on Electroencephalogram exam even with no clinical manifestation; to have brain implant; to have cardiac markpacer; diagnosed or investigating bipolarity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-9srf9vd	Effects of Auditory and Visual Stimulation on Depression Symptoms in Individuals After Bariatric Surgery	Recruiting	Intervention	2025-09-09	<NULL>	<NULL>	8265	Evaluation of the effects of Audiovisual Stimulation on Depressive-type symptoms in individuals after Bariatric Surgery: a controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9srf9vd	<NULL>	Individuals who will undergo bariatric surgery; aged between 18 and 59 years; of both sexes; residents of the municipality of Criciúma and region; and who are interested in participating in the study will be included in the study	Individuals with a history of seizures will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-3scx6qp	Effects of auricular acupuncture on mental health: a randomized clinical trial	Recruiting	Intervention	2025-09-08	<NULL>	<NULL>	8258	Effects of auriculotherapy on university students with stress, anxiety and/or depression symptoms: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Universidade Estadual do Maranhão	Programa de Pós-Graduação em Biodiversidade, Ambiente e Saúde – PPGBAS/CESC/UEMA	https://ensaiosclinicos.gov.br/rg/RBR-3scx6qp	<NULL>	The target audience for the study was all students at Universidade Estadual do Maranhão Campos Caxias; students at the Caxias Campus of the State University of Maranhão, eighteen (18) years of age or older; with an express desire to volunteer for the study and with time available to complete the assessment and submit to the sessions;According to the finite population sample calculation, stratified by proportion, with a sampling error of 5% and a 95% confidence level, a sample of 118 students was estimated for the construction of the case and control groups, randomly distributed to form groups with 59 participants	Exclusion criteria include participants who rejected or feared receiving the interventions; had a history of allergy to micropore tape or seeds; had a history of photosensitivity or skin cancer in the head and neck region; used hearing aids; had ear injuries or inflammation; were pregnant or planning to become pregnant during the study period; had discontinued sessions; were enrolled in night classes; and had received any Integrative and complementary health practices in the last three months; The discontinuation criterion involves missing two consecutive sessions or missing more than ten (10) days between sessions; had an inflammatory reaction; or expressed a desire to discontinue participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-37jy8dh	Effects of Auricular Branch Vagus Nerve Stimulation in elderly people with Mild Cognitive Impairment	Recruitment completed	Intervention	2024-08-06	<NULL>	<NULL>	7178	Effects of Auricular Branch Vagus Nerve Stimulation in elderly people with Mild Cognitive Impairment: A double-blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-37jy8dh	<NULL>	Individuals of both sexes; aged between 60 and 79 years old; diagnosed with Mild Cognitive Impairment (MCI); who present Montreal Cognitive Assessment (MoCA) with a score greater than 12, without a diagnosis of dementia and less than 26 points	Individuals with epilepsy; immunocompromised; with oncological and infectious pathologies; diagnosis of bipolarity; pacemaker holders; participants with wounds on the ear surface due to the application of electrodes to the area; symptoms of Covid-19 or testing positive for Covid-19 during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-9w92fv	Effects of Auricular Therapy in the treatment of Premenstrual Syndrome	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	1848	Effects of Auricular Therapy in the treatment of women with symptoms of Premenstrual Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9w92fv	<NULL>	WWomen aged 18-35 years; sedentary; university students enrolled regularly at the Federal University of Paraná; and who have Premenstrual Syndrome (mild to moderate) or Pre-Menstrual Dysphoric Disorder according to the criteria listed in the PSST (Premenstrual Syndrome Screening Tool)	Women classified by PSST as mild or absent Premenstrual Syndrome; in the gestational period; with irregular menstrual cycles (cycles less than 25 days or greater than 35 days); women diagnosed with secondary dysmenorrhea (fibroids, endometriosis or cysts); who have a history of abortion; cardiopathy; who use antidepressants and / or psychotropic medication in the last two months; and, that they have any type of lesion in the auricular pavilion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-67xf25	Effects of Auriculotherapy and Midazolam in anxiety control in patients submitted to extraction of third molars	Recruiting	Intervention	2016-11-21	<NULL>	<NULL>	1072	Effects of Auriculotherapy and Midazolam in anxiety control in patients submitted to exodontics of third molars	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-30	Universidade Federal de Sergipe - UFS	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-67xf25	<NULL>	exodontia indication of third molar; asymptomatic; positions and similar surgical difficulties; classified as 2B Pell &amp; Gregory (1942)	under 18 years of age patients; patients classified as ASA III or IV; drug use history for pain or anxiety in the 15 days before the beginning of the study; history of hypersensitivity to drugs, substances or materials used in this experiment; pregnancy or lactation; previous history of pericoronitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-87pc5z9	Effects of auriculotherapy on musculoskeletal pain in elementary school teachers	Data analysis completed	Intervention	2021-12-10	<NULL>	<NULL>	5095	Effects of auriculotherapy on musculoskeletal disorders in elementary school teachers	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Tiago Veloso Neves	Fundação Escola de Saúde Pública de Palmas	https://ensaiosclinicos.gov.br/rg/RBR-87pc5z9	<NULL>	The study included teachers of all ages and genders, who had musculoskeletal disorders and who agreed to participate in the study by signing the Informed Consent Form (FICF).	Teachers who did not have musculoskeletal disorders, who were on sick leave, maternity leave, vacation, medical certificate, and/or refused to participate in the research, and people who had an allergy to adhesive tape were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-3njdgg4	Effects of Auriculotherapy on Stress in healthcare workers	Not yet recruiting	Intervention	2024-05-24	<NULL>	<NULL>	7023	Effects of Auriculotherapy on subjective and objective Stress in healthcare workers: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade do Estado da Bahia - Departamento Ciências da Vida	Universidade do Estado da Bahia - Departamento Ciências da Vida	https://ensaiosclinicos.gov.br/rg/RBR-3njdgg4	<NULL>	Volunteers with salivary cortisol and perceived stress levels above the general average; workers from Family Health Units; both genders; age between 18 and 70 years	Pregnant women; workers using antidepressants; bleeding oral lesions; treatment with auriculotherapy by other means	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-10zxt9m2	Effects of auriculotherapy to reduce anxiety symptoms in students	Recruiting	Intervention	2021-02-10	<NULL>	<NULL>	4533	"Effectiveness of auriculotherapy for anxiety symptoms in students: an essay
randomized clinical trial"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-18	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-10zxt9m2	<NULL>	students enrolled in Medicine, Nursing and Physiotherapy; schedule time for those scheduled; be over 18 years old.	pregnant women; perform some other pharmacological or non-pharmacological treatment for anxiety; people with previous negative experiences in the practice of auriculotherapy; withdrawal or refusal to continue participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-47hhbj	Effects of Auriculotheray in women during labor	Recruiting	Intervention	2015-06-07	<NULL>	<NULL>	504	Effects of Auriculotheray in women during labor: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Enfermagem da Universidade Estadual de Campinas	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM/UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-47hhbj	<NULL>	99 women in labor; 37 weeks gestation or more; single and cephalic fetus; cervical dilation greater than or equal to 4 cm; two or more contractions in 10 minutes; skin integrates the ear.	Pregnant women with severe hypertensive disease; pregnancy bleeding; previous cesarean section; dilated cervix equal to or greater at 7 cm; analgesic drug use for less than 6 hours of admission in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6h3g4k	Effects of B-alanine and sodium bicarbonate supplementation on time to finish the 5 km race.	Recruitment completed	Intervention	2018-11-08	<NULL>	<NULL>	2321	Effects of B-alanine and sodium bicarbonate supplementation on the performance of runners of of Aracaju-se city.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-02	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6h3g4k	<NULL>	The subjects should have presented a weekly training volume between 25 and 40km; and running pace between 4.5 and 5.5 min/km (3,69 and 3,03 m/s) in a 5km run.	Absence in 10% of the training sessions during the study; absence on the assessments; runners that have consumed creatine or BA in the last 3 and 6 months; bicarbonate or caffeine in the last month	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-8twhkb	Effects of Babassu Coconut Oil intake on fatigue and quality of life of breast cancer women	Recruitment completed	Intervention	2017-10-24	<NULL>	<NULL>	3371	Effects of supplementation of Babassu Coconut Oil in the fatigue and quality of life of women with breast cancer	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8twhkb	<NULL>	Individuals of the female gender; age greater than or equal to 30 and up to 59 years; in all anti-neoplastic treatment; not be using dietary supplementation for at least 3 months; stage IIA to IV of the disease.	Pregnant women, patients unable to communicate verbally and even to get around, mental disorders, use of mineral oil or lactulone, carriers of some biliary disease, use of hypocholesterolemic medication, not want to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-9bv3dc9	Effects of balance strength training to prevent falls in the elderly population with cognitive decline	Not yet recruiting	Intervention	2022-03-25	<NULL>	<NULL>	5303	Effects of instability resistance training for falls prevention in community-dwelling older adults with probable cognitive impairment: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-31	Universidade Federal do Vale do São Francisco - UNIVASF	Universidade Federal do Vale do São Francisco - UNIVASF	https://ensaiosclinicos.gov.br/rg/RBR-9bv3dc9	<NULL>	Participants both sex, male or female, aged 65 and older; are able to walk 10 meters without assistance; present subjective cognitive complaints and / or score less than 26 (of a total of 30 points) in Montreal Cognitive Assessment (MoCA); live independently in the community; and be able to read, write, speak and understand in the Portuguese language	Be engaged in structured exercise (e.g. aerobic, resistance or mind-body exercise classes) in the last three months; have had a clinical condition that interferes with exercise (e.g., angina pectoris); have had a previously diagnosed cardiovascular (e.g., stroke), neurodegenerative (e.g., Parkinson’s disease) or psychiatric (e.g., major depression) disease; have severe musculoskeletal or vestibular disorders; or are unable to complete the assessments or intervention due to inadequate vision and/or hearing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-8kvgy3	Effects of balance training associated with cardiorespiratory training in the water about the falls risk and funcionality in women	Data analysis completed	Intervention	2016-03-16	<NULL>	<NULL>	755	Therapeutic approach in the quality of life and elderly functionality	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Pontificia Universidade Católica de Goiás	Adriana Marcia Monteiro Fantinati	https://ensaiosclinicos.gov.br/rg/RBR-8kvgy3	<NULL>	Women over 45 years old, participants of UNATI (Universidade Aberta à Terceira Idade) PUC - GO (Pontificia Universidade Católica - Goiás), capable according with the Mini Mental State Examination (MMSE) with score minimum of 17, considering illiterate , 75% presence in cardiorespiratory training in the water and in balance training in solo for a period of three months , who participated in all assessments proposed in the study and signed the Informed Consent and Informed.	Women who did not pass in the screening UNATI (Universidade Aberta a Terceira Idade) PUC - GO (Pontifícia Universidade Católica - Goiás) prior to attending the program, did not participate in Six Minutes Walk Test (6MWT) due the following contraindications: recent electrocardiographic changes; recent myocardial infarction acute ; high resting blood pressure (systolic bigger then 180 mmHg; diastolic bigger then 100 mmHg); unstable angina during the last month; heart rate greater than 120 beats per minute.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-29x9zbc	Effects of bandaging on pain and abdominal muscle separation in postpartum women: a randomized controlled trial	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7735	Effects of Kinesio Taping on pain and diastasis of the rectus abdominis muscles in postpartum women: a randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-17	Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-29x9zbc	<NULL>	Postpartum women; normal-risk pregnancy; single fetus; age between 18 and 40 years; up to 72 hours postpartum; via vaginal delivery or cesarean section; full-term birth between 37 and 42 weeks; no abdominal surgeries in the last 12 months	Obstetric complications; postpartum hemorrhage; postpartum depression; infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3hj4ny	Effects of baru oil or mineral oil supplementation on the bowelfunction of hemodialysis patients	Recruitment completed	Intervention	2019-03-26	<NULL>	<NULL>	2549	Effects of exercise and nutritional intervention on functional capacity, nutritional status, health perception and quality of life of hemodialysis patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Goiás	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-3hj4ny	<NULL>	Chronic renal patients in an adequate hemodialysis treatment (Kt / V greater than 1.2), via arteriovenous fistula, of both sexes, aged between 25 and 70 years and who did not use laxative.	Patients with a history of acute myocardial infarction in the last six months; recent hospitalization (less than three months from the start of the study), decompensated diabetes, presence of thyroid dysfunction, patients with acute infections and patients who presented food intolerance to baru or allergy to any oilseed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-7trttf	Effects of baru oil supplementation on body composition, inflammation, oxidative stress, lipid profile and blood fatty acids of hemodialysis patients	Recruitment completed	Intervention	2019-03-20	<NULL>	<NULL>	2532	Effects of exercise and nutritional intervention on functional capacity, nutritional status, health perception and quality of life of hemodialysis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Goiás	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-7trttf	<NULL>	Chronic renal patients undergoing adequate hemodialysis treatment (Kt / V superior at 1.2), via arteriovenous fistula, of both sexes, aged between 25 and 70 years.	Patients with a history of acute myocardial infarction in the last six months; recent hospitalization (less than three months from the start of the study), decompensated diabetes, presence of thyroid dysfunction, patients with acute infections and patients who presented food intolerance to baru or allergy to any oilseed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5qwkqd	Effects of bed bath on physiological changes: randomized clinical trial	Recruiting	Intervention	2018-07-26	<NULL>	<NULL>	2063	Effects of bag bath and bed bath on oxi-hemodynamics changes: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-13	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5qwkqd	<NULL>	Admitted to the Intensive Care Unit studied; have an age of 18 years or more; be submitted to  procedure bed bath for purposes of promoting comfort and / or body hygiene.	patients with medical diagnosis of neurological alterations that compromise the regulation of body temperature and burns of great extent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-2j5294	Effects of beer on recovery of cardiac activity after aerobic exercise	Recruitment completed	Intervention	2019-08-28	<NULL>	<NULL>	2915	Effects of beer on autonomic heart rate control recovery following submaximal aerobic exercise	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-07	Faculdade de Juazeiro do Norte	Faculdade de Juazeiro do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2j5294	<NULL>	Eutrophic; age 18 to 40 years	Smoking; cardiorespiratory and neurological disorders; musculoskeletal injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-10kjk5cq	Effects of Beetroot Juice Supplementation on the Physical Performance of physical exercisers	Recruitment completed	Intervention	2026-01-12	<NULL>	<NULL>	8739	Effects of Beetroot Juice Supplementation on the Physical Performance of physically active subjects	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-15	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	Be aged between 18 and 59 years; have accumulated experience with some form of resistance training or CrossFit for at least six months; perform a minimum of four training sessions per week.	"Have any physical problems during the study that prevent them from carrying out the physical tests (e.g. osteoarticular injuries); start consuming other ergogenic resources during the study that may influence physical performance, such as creatine, caffeine, beta alanine and sodium bicarbonate;
adopting specific dietary regimes during the study that may affect physical performance (e.g. weight loss diet, low carb diet, ketogenic diet, etc.); not completing all stages of the study for any reason."	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-3jv46h	Effects of beta-alanine supplementation in muscle strength and mass.	Data analysis completed	Intervention	2020-06-19	<NULL>	<NULL>	3928	Effects of beta-alanine supplementation in neuromuscular parameters of resistance-trained young men.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3jv46h	<NULL>	individuals should have a minimum experience of 6 months with the regular practice of strength training; training frequency greater than or equal to three weekly sessions.	Those who might have clinical limitations that could compromise their health and safety would be excluded. Those who practice other types of strength training would also be excluded. During the period, the volunteer who was injured, regardless of the reason, or if he was absent from more than three consecutive training sessions, would be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-8jmj76b	Effects of bioavailable curcumin (Cureit®) supplementation in pre-sarcopenic and sarcopenic patients with gastrointestinal tract cancer	Recruiting	Intervention	2023-05-25	<NULL>	<NULL>	6109	Effects of curcumin supplementation in pre-sarcopenic and sarcopenic patients with cancer of the gastrointestinal tract	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de São Paulo	Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-8jmj76b	<NULL>	Volunteers diagnosed with some type of cancer in the gastrointestinal tract confirmed by biopsy or imaging; both genders; age over 18 years, Performance Status of Eastern Cooperative Oncology Group (ECOG) score less than or equal to 3; SARC-CalF greater than or equal to 11; decreased muscle mass; and/or decreased strength.	Volunteers using the chemotherapy drug Irinotecan; in dietary use of curcumin or supplements with curcuminoids or thermogenic; anticoagulants; presence of acute infection during the protocol; pregnant women; lactating women; cognitive limitations; physical limitations that prevent data collection; diagnosis of liver and kidney pathologies, gastric ulcer; participation in other clinical trials; use of Enteral or Parenteral Nutrition Therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-3hyqb9r	Effects of Blood Flow Restriction Induced by a Non-Elastic Band on Repetition Volume and Perceptual Responses During Resistance Exercise: A Randomized Crossover Trial	Recruiting	Intervention	2026-01-23	<NULL>	<NULL>	8791	Analysis of Perceptual Responses and Repetition Performance During Low-Load Resistance Exercise With Practical Blood Flow Restriction: A Randomized, Controlled, Crossover Experimental Trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-06	Universidade Estadual da Paraíba	<NULL>	<NULL>	<NULL>	Males aged between 18 and 34 years were considered eligible if they met the following inclusion criteria: engagement in resistance training for at least six months on a continuous basis; resting blood pressure below 140/90 mmHg; absence of a history of cardiovascular or metabolic diseases; absence of osteomyoarticular injuries within the previous year	Participants using substances capable of affecting exercise performance or perceptual responses; inability to properly perform maximal strength tests (one repetition maximum).	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-3jk98z7	Effects of Blood Restriction Muscle Training associated with Light Therapy	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8529	Effects of Blood Flow Restriction Training associated with Photobiomodulation Therapy	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Fundação do ABC	<NULL>	<NULL>	<NULL>	Men and women; Healthy individuals; Aged between 18 and 30 years; Body mass index classification up to 30 kilograms per square meter	Individuals with musculoskeletal injuries undergoing treatment or with a history of upper limb surgery; Clinical manifestations that prevent exercise, such as changes in blood pressure, heart rate, and/or respiratory rate	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:50
RBR-4mxb77	Effects of Body Awareness Therapy in heart rate variability of university students	Recruitment completed	Intervention	2016-12-07	<NULL>	<NULL>	1093	Body Awareness Therapy in heart rate variability of university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-23	Universidade Estadual Paulista - FCT/UNESP	Universidade Estadual Paulista - FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-4mxb77	<NULL>	Healthy volunteers; both genders; aged 18-25 years; higher education students	Smokers; presence of renal; cardiovascular and / or respiratory disease; make use of drugs that influence the autonomic activity of the heart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-99qw5h	Effects of body electrical stimulation after the stomach reduction surgery	Recruiting	Intervention	2016-08-12	<NULL>	<NULL>	958	Functional, clinical and systemic effects of the body electrical stimulation on bariatric surgery postoperative	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-04	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-99qw5h	<NULL>	This research will include obese (BMI 35 kg / m2) or morbidly obese (BMI 40 kg / m2) for at least three years or more without positive results to conventional treatments (pharmacological or not) aged 20 to 45 years will undergo surgery of Gastric Bypass (CBG). Patients with BMI&gt; 30 kg / m2 may also be included according to medical team decision regarding the presence of important comorbidities indicated by Brazilian Bariatric Consensus.	Exclusion criteria are volunteers with orthopedic or neurological impairments that unable participation in an exercise program; myocardial infarction (within the beginning of the six-month study period); implanted pacemaker or any metallic synthesis; unstable angina; chronic disorders of the heart rhythm; moderate or severe valvular heart disease; consistent story of heart disease; uncontrolled hypertension; uncontrolled diabetes mellitus and / or insulin-dependent; beta-blocker users; postmenopausal women and participation in a regular program of physical activity at baseline. It will be also excluded from the present study any COPD volunteers or patients presenting other respiratory diseases or who present any contraindication to cardiopulmonary exercise test or condition that may limit the performance of the functional tests; distal artery diseases; inflammatory diseases; kidney diseases; and liver diseases with documented diabetic neuropathy; cognitive impairment; difficulty in understanding and / or adherence to study procedures; reported using illicit drugs and pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-3x9gb8s	Effects of body vibration combined with respiratory physiotherapy in patients with pulmonary emphysema and osteoporosis: a controlled clinical study	Not yet recruiting	Intervention	2025-05-05	<NULL>	<NULL>	7982	Evaluation of the efficacy and safety of a whole-body vibration protocol combined with pulmonary rehabilitation on the functional capacity and bone quality of patients with Chronic Obstructive Pulmonary Disease: a prospective randomized controlled single-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3x9gb8s	<NULL>	Sign the informed consent form thus authorizing their participation in the research; participants with a  diagnosis of Chronic Obstructive Pulmonary Disease; men or women; age over 45 years; they will need to walk without assistance or supervision from others even if they use some type of walking aid	Hypercalcemia; severe vitamin D deficiency (25-hydroxyvitamin D &lt; 12 nanograms per milliliter); uncompensated thyroid function disorders; creatinine clearance &lt; 45 milliliters per minute; recent history of hip fracture (&lt; 12 months); alcohol or illicit drug dependence; use of teriparatide; calcitonin; androgens; estrogens or selective estrogen receptor modulators in the past 6 months; use of bisphosphonates in the past 12 months; osteoarthritis with synovitis; use of osteoarticular prostheses; severe heart failure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-8rmv3n6	Effects of Body Weight Training on blood components, functional capabilities and blood pressure in Hypertensive elderly women	Recruitment completed	Intervention	2023-05-03	<NULL>	<NULL>	6048	Effects of Calisthenics Training on biochemical, functional and hemodynamic aspects in Hypertensive elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8rmv3n6	<NULL>	Women aged between 60 and 75 years; vaccinated against COVID-19; duly medicated hypertensive patients; non smokers; with a BMI below 32 kg/m²; non-practitioners of physical exercise on a regular and systematic basis for at least three months; without musculoskeletal problems or cardiovascular complications (besides hypertension) that prevent the practice of systematic physical exercises; no diagnosis of Type I Diabetes Mellitus or lung disease; with medical evaluation involving a clinical anamnesis and medical certificate releasing the participation in a training program with physical exercises	Mulheres não vacinadas contra COVID-19; hipertensas não-medicadas; fumantes; com IMC acima de 32 kg/m²; praticantes de exercícios físicos de forma regular e sistemática; com problemas osteomusculares ou complicações cardiovasculares impedindo a prática de exercícios físicos sistemáticos; com diagnóstico de Diabetes Mellitus tipo I ou doença pulmonar; sem avaliação médica envolvendo uma anamnese clínica e atestado médico liberando a participação em um programa de treinamento com exercícios físicos	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-4k29x2f	Effects of Bodybuilding Exercise performed at night on sleep in adults	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7973	Effects of a Resistance Exercise session performed earlier versus later at night on sleep in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4k29x2f	<NULL>	Being between 20 and 55 years old; both sexes; doing resistance exercises more than 2 days a week	Cardiovascular, respiratory, osteoarticular diseases; use of medications; smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-2skg8p4	Effects of bodyweight physical training on the physical and mental health of military police officers from the special actions battalion	Not yet recruiting	Intervention	2024-12-19	<NULL>	<NULL>	7614	Effects of a bodyweight Physical Training protocol on the physical and mental health of military police officers from the special actions battalion	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2skg8p4	<NULL>	Military police officers from the 2nd Special Actions Battalion of the Military Police - BAEP de Santos; who agree to participate in the study; have worked in the military police for at least 1 year; do not have a previous psychiatric diagnosis; age between 26 and 50 years; male	Military police officers who use medicines that modulate the nervous system; and/or who present an attendance rate of less than 75% in the physical training sessions proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-8fsspyy	Effects of Botulinum Toxin Type A in patients with chronic orofacial pain	Data analysis completed	Intervention	2020-12-15	<NULL>	<NULL>	6357	Comparison of the efficacy of Botulinum Toxin Type A in patients with refractory chronic orofacial pain according to different somatosensory profiles	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8fsspyy	<NULL>	Volunteers of both genders; aged between 20 and 50 years; with myofascial Temporomandiibular Disorders; in pain for more than three months; refractory to conventional therapies	Volunteers with facial and Temporomanbular Joint trauma; using full dentures or removable partial dentures; ongoing orthodontic treatment; blood dyscrasia patients; with presence of arthritis; arthrosis; diabetes; neurological pathologies; fibromyalgia; who received tetanus vaccine or botulinum toxin injections in the three months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-8q6kj3n	Effects of brain electrical stimulation combined with speech therapy on the voice and speech of individuals with Parkinson’s disease	Not yet recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8605	Effects of tDCS combined with speech therapy on the voice and speech of individuals with Parkinson’s disease: a randomized clinical trial with follow-up.	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Departamento de Fonoaudiologia	<NULL>	<NULL>	<NULL>	Individuals with a medical diagnosis of Parkinson’s disease, at stages I to IV on the Hoehn &amp; Yahr scale, aged over 18 years, of both sexes; being in the “on” medication state during the collection of voice samples; presenting some self-reported or clinically detected communication complaint related to speech and/or voice, as identified by the evaluator during the initial contact	Individuals with severe cognitive or motor impairments that prevent comprehension and/or proper execution of the proposed exercises; pregnant women; individuals reporting other neurological or psychiatric disorders; history of seizures/epileptic crises; previous laryngeal surgery; or history of head and neck surgery (such as deep brain stimulation). Participants who miss more than one session or experience any serious adverse event will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-8spzvbj	Effects of brain stimulation and video games on cognitive and motor function in older adults with mild cognitive impairment	Recruiting	Intervention	2025-08-14	<NULL>	<NULL>	8208	Acceptability, safety and efficacy of non-invasive brain stimulation on cognitive and motor functioning in older adult patients with mild neurocognitive impairment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-12	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8spzvbj	<NULL>	Present with mild impairment cognitive; both sexes (female and male); absence of dementia based on a score on the Clinical Dementia Rating scale equal or less 0,5 according to Hughes et al 1982; age between 50 and 75 years; signs of cognitive decline according to the Montreal Cognitive Assessment cutoff points, adjusted for age and education by Apolinario et al 2018; no or minimal functional impairment due to cognition according to the score on the Activities of Daily Living Questionnaire equal or less 0,33 according Medeiros and Guerra 2009; no unstable disease that prevents planned exercise, as well as absence of known organic or psychiatric condition that compromises cognition; normal or corrected visual and auditory acuity; ability to walk independently; report a minimum schooling age of four years so that there is no impairment in performance in cognitive assessment instruments due to the influence of educational level  according Apolinario et al 2018 and Avila et al 2009; have not previous experience with the Nintendo Switch video game; have not undergone physiotherapy treatment in the last 2 months before the start of the study; have no metal implants in the head	Participants will not be included in the study if they require high-level home care; have neurological disorders; have bone deformities that make it difficult to maintain a bipedal posture; have unstable cardiovascular diseases or other uncontrolled chronic conditions that interfere with the safety and conduct of training; have a history of severe alcohol and drug abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-2d3jj9t	Effects of Brain Stimulation combined with Neural Mobilization in people with sciatica	Recruitment completed	Intervention	2023-06-04	<NULL>	<NULL>	8106	Effects of Transcranial Direct Current Stimulation on pain, disability and quality of life in individuals with chronic sciatica: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-28	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2d3jj9t	<NULL>	"Men and women between 18 and 64 years. Clinical diagnosis of low back-related leg pain for at least three months. Radiating pain to at least one lower limb in the last two weeks. Presence of two or more of the following clinical criteria; positive neural tension test (SLRT); neurological deficit; pain below the knee; pain more present in the leg than in the lumbar; and subjective sensory symptoms. 
Not being under physiotherapeutic treatment for low back-related leg pain for at least 60 days"	To present any contraindication for tDCS brain stimulation; Douleur Neuropathique Questionnaire score under 4 points; Pain Numeric Rating Scale score under 3 points; Presence of Red Flags for critical spinal pathology; Have been submitted to some type of infiltration in the spine in the last six months; History of abdominal, lumbar or lower limb surgery in the last year; Inability to respond to the study&apos;s assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-5qjg9t	Effects of brain stimulation in people with Anxiety Disorder	Recruitment completed	Intervention	2019-04-03	<NULL>	<NULL>	2582	Effects of Transcranial Direct Current Stimulation in persons suffered by Generalized Anxiety Disorders	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5qjg9t	<NULL>	Be between 20 and 40 years old; clinical diagnosis according to the criteria of the American Psychiatric Association - DSM-V (2014), of TAG; not going through psychotherapy at the time of the study; ability to understand the purpose of the research and to answer the scales and questionnaires.	Be pregnant at the time of data collection; have a metallic, cerebral or pacemaker implant; history of epileptic disease, convulsive crisis and dependence on alcohol or narcotic substance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-48gcrk8	Effects of Brain Stimulation on Anxiety, Inhibition Control and Risk taking behavior in young university students	Not yet recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7029	Effects of Transcranial Direct Current Stimulation on Anxiety, Inhibition Control and Risk taking behavior in young university students	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal do Delta do Parnaíba	Universidade Federal do Delta do Parnaíba	https://ensaiosclinicos.gov.br/rg/RBR-48gcrk8	<NULL>	University students; aged between 18 and 30 years old; from public and private institutions in the city of Parnaíba-PI; of both genders; who are currently attending university; scoring ≥ 15 points on the Hamilton Anxiety Rating Scale (HAM A); answering negatively to all questions on the non-invasive techniques screening instrument	Having a history of seizures, epilepsy, traumatic brain injury, or unexplained loss of consciousness; having a diagnosis of any neurological and/or cognitive conditions; currently being prescribed antipsychotic, hypnotic, or sedative medications; abusing/being dependent on substances, excluding tobacco and/or caffeine; having metallic implants in the body, such as pacemakers; presenting with skin diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-4yt3pvc	Effects of Brain Stimulation on Runners	Recruitment completed	Intervention	2023-03-27	<NULL>	<NULL>	5963	Effects of Transcranial Direct Current Stimulation in Athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-07	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4yt3pvc	<NULL>	Individual volunteers of their own free will, with a minimum of 01 year of training experience in the Running Club, between 18 and 32 years of age, with participation in a 5 km race or training in the last two months with a maximum time of 35 minutes to complete the race, must properly complete and sign the Informed Consent Form authorizing participation in the research and participate in all tests as directed.	Individuals who do not perform all the steps as instructed; present depravity in the upper respiratory tract; injuries that make it impossible to perform maximum effort during the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-943djg	Effects of branched-chain amino acid consumption in association with omega-3 in clinical-nutritional, cardiorespiratory, metabolic parameters and quality of life in cachectic patients	Recruiting	Intervention	2017-08-16	<NULL>	<NULL>	1334	Impact of branched-chain amino acid supplementation on omega-3 association in clinical, nutritional, cardiorespiratory, metabolic parameters and quality of life in cachectic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal do Maranhão - UFMA	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-943djg	<NULL>	Individuals over 18 years of age; pre-cachexia; cachexia; stability (absence of modifications in drug therapy in the last 6 weeks or hospitalizations in the last 3 months).	Individuals over 85 years of age; refractory cachexia (pre-terminal state, life expectancy &lt;3 months, intense catabolism, lack of response to drug therapy); palliative care; use of branded step; water imbalance; allergy to nutritional composition of supplements; withdrawal of consent; adherence to intervention of less than 75%; refusal of proposed supplementation; worsening after intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-2jtk8cn	Effects of Brazil nut supplementation on inflammation and oxidative stress in patients with kidney issues on peritoneal dialysis	Not yet recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8593	Effects of Brazil Nut Supplementation on inflammation and oxidative stress in patients with Chronic Kidney Disease undergoing Peritoneal Dialysis	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Hospital Universitário Pedro Ernesto	<NULL>	<NULL>	<NULL>	patients with chronic kidney disease undergoing peritoneal dialysis for at least three months; both sexes; age over eighteen years; regular nutritional follow up at the peritoneal dialysis outpatient clinic of pedro ernesto university hospital; conducted every two months	smokers; pregnant women; lactating women; use of antiinflammatory drugs; individuals who are allergic, intolerant, or have a habitual intake of brazil nuts; infectious diseases, liver diseases, aids, and cancer; use of antioxidant supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-5mzzd4	Effects of Brazilian nut consumption on the expression of factors that regulate inflammation in patients with coronary artery disease	Recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1423	Effects of Brazil nut supplementation (Bertholletia excelsa H.B.K.) in Nrf2 and NFkB expression in coronary arterial disease patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Pós-graduação em Ciências Cardiovasculares, Universidade Federal Fluminense	Pós-graduação em Ciências Cardiovasculares, Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5mzzd4	<NULL>	Will be included in the study: men and women over 18 and non-smokers.	Patients with autoimmune and infectious diseases, pregnant and lactating women; Cancer and AIDS; Patients taking catabolic drugs and antioxidant vitamin supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-10k2wxrg	Effects of Breaks Sedentary Behavior with unsupervised Isometric Exercise in Sedentary adults	Recruiting	Intervention	2023-03-16	<NULL>	<NULL>	5949	Effects of Breaks from Sedentary  Behavior with unsupervised  Isometric Exercise on Vascular Function, Blood  Pressure and Cardiac Autonomic Modulation in Sedentary adults: Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-10	Universidade Federal Rural de Pernambuco	Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10k2wxrg	<NULL>	Do not have a diagnosis of cardiovascular disease and diabetes, do not have high cardiovascular risk, do not participate in the physical exercise program for at least six months, occupational activity that requires more than six sitting times per day, and, do not being a smoker or being on medication.	Show adherence below 85% of the training sessions, adhere to another supervised physical exercise program, and,  change the characteristics of occupational activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-244m9ng	Effects of Breathing and Leg Muscle Training in Patients with Heart Failure	Recruitment completed	Intervention	2023-10-16	<NULL>	<NULL>	6509	Effects of Inspiratory and Peripheral Muscle Training in Patients with Heart Failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Instituto Nobre de Cardiologia	Centro Universitário Nobre	https://ensaiosclinicos.gov.br/rg/RBR-244m9ng	<NULL>	Individuals of both sexes with heart failure (CHF); Functional class III and IV according to the New York Heart Association classification; aged over 18 years.	Patients with unstable ventricular arrhythmia; Peripheral vascular disease; Acute respiratory disease; Unstable angina; Aortic stenosis; Current smoking; Chronic kidney disease or undergoing hemodialysis; Fever and/or infectious disease; Malignant neoplasms; Cognitive impairment; Failure to perform the proposed techniques; Failure to sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-4z5ndwm	Effects of breathing exercises and vocal training on the voices of amateur evangelical singers	Data analysis completed	Intervention	2026-03-12	<NULL>	<NULL>	8972	Effects of Vocal Training using voiced oral high-frequency oscillation with a respiratory device and Vocal Function Exercises in amateur evangelical singers	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Departamento de Fonoaudiologia da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Be between 18 and 45 years of age; have been singing in an evangelical church for at least one year; report good general health; both sexes.	Individuals with vocal complaints or vocal alterations identified during prior vocal screening; singers with cardiac or pulmonary conditions; smokers; self-reported hearing loss; neurological or psychiatric disorders; and scores higher than five on the Vocal Disorder Screening Index protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-8r2twnx	Effects of breathing training on lung health, fitness, and heart rate after coronary artery bypass graft surgery	Recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8438	Effects of inspiratory muscle training on lung function, functionality, and heart rate variability after myocardial revascularization: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-22	Universidade Federal do Piauí Campus Universitário Ministro Petrônio Portella	Universidade Federal do Piauí Campus Universitário Ministro Petrônio Portella	https://ensaiosclinicos.gov.br/rg/RBR-8r2twnx	<NULL>	Volunteers undergoing Myocardial Revascularization surgery; able to complete the Cardiac Rehabilitation program phase II; both genders; without obesity; preserved cognition	Volunteers with diseases that limit functionality or that interfere with the performance of respiratory muscle training; do not sign the Informed Consent Form; fail to participate in one of the research stages; attend less than eight weeks or 24 sessions in the cardiac rehabilitation program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4fxmhs7	Effects of Caffeine and Capsaicin on Performance of Brazilian Jiu-Jitsu Athletes	Recruiting	Intervention	2026-03-16	<NULL>	<NULL>	8981	Investigation into the possible acute effects of caffeine and capsaicin supplementation on performance and psychophysiological responses in Brazilian jiu-jitsu athletes	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-17	Escola de Educação Física da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Male Brazilian Jiu-Jitsu athletes. Age between 18 and 35 years. Minimum blue belt rank. Regular practice of Brazilian Jiu-Jitsu training for at least 12 months. Absence of self-reported musculoskeletal injuries in the upper limbs in the previous six months. Agreement to abstain from consuming products containing caffeine and other ergogenic supplements at least 48 hours before each experimental session. Voluntary participation through signing the Informed Consent Form.	History of cardiovascular, metabolic, neurological, or gastrointestinal diseases. Use of medications or supplements that may interfere with physical performance or cardiovascular responses. Hypersensitivity or intolerance to caffeine or capsaicin. Smoking. Alcohol consumption in the 24 hours prior to experimental sessions. Failure to comply with the pre-test recommendations established by the experimental protocol. Occurrence of adverse effects related to supplementation during experimental sessions. Voluntary withdrawal of the participant at any stage of the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3gx2h7f	Effects of caffeine chewing gum on physiological and 50-m time-trial freestyle swimming performance	Recruitment completed	Intervention	2025-10-01	<NULL>	<NULL>	8338	Effect of caffeine chewing gum supplementation on interval training and freestyle swimming performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-14	Universidade Federal de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3gx2h7f	<NULL>	Be at least 18 years of age; to be of the masculine gender; regularly training and competing in swimming for at least 5 years; being free from chronic diseases; self-report of not regularly using any substance that could interfere with metabolic responses; self-report of not regularly using any nutritional supplement containing intracellular buffers	Possess a physical limitation that makes them unable to swim; engage in physical activity within 24 hours preceding the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-9ngb95	Effects of calcium supplementation in the prevention of preeclampsia in hypertensive pregnant women.	Data analysis completed	Intervention	2018-11-07	<NULL>	<NULL>	5448	Effects of calcium use to evaluate efficacy and safety in the treatment of pregnant women with gestational hypertension: randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-29	Universidade Federal de São Paulo	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-9ngb95	<NULL>	Pregnant women over 18 years of age; single fetus; primigravidae; diagnosis of gestational hypertension; overweight and/or obesity; be at least 20 weeks pregnant; low socioeconomic factor; low dietary calcium intake (less than 800mg/day); non-use of drugs that interfere with calcium absorption (corticosteroids; thiazides; thyroid hormones)	Pregnant women with polyhydramnios; severe anemia; fetal death; severe preeclampsia; history of hypertension before pregnancy; placental abruption; premature rupture of membranes; abnormal umbilical artery doppler; uteroplacental insufficiency; other pre-existing medical condition; any contraindication to calcium supplementation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-45fpgqh	Effects of Caloric Restriction combined with intermittent fasting on metabolism and body composition of individuals with Severe Obesity - MACRO study	Recruiting	Intervention	2023-08-01	<NULL>	<NULL>	7363	Effects of Caloric Restriction combined with Time Restricted Eating strategy on metabolism and body composition of individuals with Severe Obesity - MACRO study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Instituto de Nutrição - Universidade do Estado do Rio de Janeiro	Instituto de Nutrição - Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-45fpgqh	<NULL>	Adults aged 20 years and over; of both sexes; with a body mass index (BMI) &gt; 40 kg/m2	Individuals who have the following conditions that may interfere with body composition or Basal metabolic rate(BMR); pregnancy; lactation; use of illicit drugs; infectious or oncological diseases; thyroid disorders; heart, kidney, liver, or lung insufficiency; use of medications that alter energy metabolism (corticosteroids, beta-blockers, sulfonylureas, Glucagon-like Peptide-1 (GLP1) agonists, dipeptidil peptidase 4 (DPP4)  inhibitors, and Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors); use of medications for obesity treatment (serotonergic, noradrenergic, and inhibitors of intestinal lipid absorption); individuals who have undergone calorie restriction (CR); have experienced a body mass modification &gt;10% in the last six months; have undergone bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-6p9769y	Effects of cancer treatment on oral health and ways to manage them	Not yet recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8584	Impact of oncological treatment on oral health: side effects and therapeutic alternatives	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-20	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients over 18 years of age, of both sexes, with a diagnosis of head and neck cancer who will begin oncologic treatment. Participants must agree to use the alternative mouth rinse containing green tea and hyaluronic acid from the New Care line. They must also authorize clinical evaluations and weekly follow-ups during treatment and in the post-radiotherapy period. All participants will be required to read, understand, and sign the Informed Consent Form, confirming their willingness to participate in the study and allowing the collection and analysis of clinical data	Patients who have a history of allergy or hypersensitivity to any component of the alternative mouthwash (green tea, hyaluronic acid, and other ingredients of the New Care line); who do not agree to participate in clinical evaluations; who do not agree to provide their personal information; who do not accept the conditions of the Informed Consent Form; or who are severely debilitated and not fit to undergo evaluations and follow-up after the end of radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-10n7gx74	Effects of cannabis components (THC and CBD) on motor and non-motor symptoms of Parkinson&apos;s disease: a placebo-controlled clinical study	Recruitment completed	Intervention	2024-03-21	<NULL>	<NULL>	6885	Effect of THC and CBD cannabinoids combined on motor and non-motor symptoms of Parkinson&apos;s disease: a double-blind, randomized, placebo-controlled clinical trial (cpf study)	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2024-01-05	Universidade Federal da Integração Latino-Americana	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10n7gx74	<NULL>	Previous diagnosis of idiopathic Parkinson disease; Parkinson disease stage 3 or lower according to the Hoen and Yahr scale; age over 50 years; male or female; clinical manifestation of Parkinson Disease; stable treatment for at least 30 days; sign the informed consent form ICF	Medical decision that participation in the study is not best for the patient; presence of any condition that does not allow the protocol to proceed safely; clinically significant renal, hepatic and cardiovascular disorders previously identified or verified in the selection exams; use cannabinoids through any route of administration; diagnosis of alcohol dependence; history or have first-degree relatives with a history of any level of psychosis; have participated in clinical research projects in the two months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-4mztsnq	Effects of cannabis extract cream on nerve and blood-deprived wound healing: randomized trial	Not yet recruiting	Intervention	2025-11-07	<NULL>	<NULL>	8490	Effects of Cannabis extract cream on the healing process of neuropathic and ischemic wounds: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Sociedade De Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Age 18 years or older. diagnosis of type 2 diabetes mellitus. presence of neuropathic or ischemic wound in lower limbs. under follow-up at primary health units or at Policlínica Santa Maria in the city of Cajazeiras. medical prescription for use of the Cannabis-based cream. signing of the informed consent form	Wounds not related to diabetes such as those of traumatic or burn origin. known allergy to any component of the cream formulation. simultaneous participation in another clinical trial. presence of severe clinical or psychiatric conditions that impair protocol adherence. pregnancy or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:06
RBR-3jsvtbr	Effects of Cannabis Oil on respiratory and cardiovascular function in healthy individuals: a randomized clinical trial study	Recruiting	Intervention	2024-04-30	<NULL>	<NULL>	6980	Acute effects of the action of Cannabis Oil in Full Spectrum protection and THC isolate on respiratory mechanics, peripheral cardiovascular hemodynamics and muscular electrical activity in healthy individuals	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-3jsvtbr	<NULL>	Both sexes; young people; between 18 and 50 years old; who declare themselves healthy; with body mass index (BMI) within normal limits; that do not present changes in respiratory function; do not present uncontrolled/treated psychological disorders; do not use regular medications; have not had exposure to Cannabis in the last 6 months	Dropouts; are unable to understand or carry out any of the study steps; present some clinical instability during the procedures (HR greater than 85% of their maximum HR; present before or during the assessment hypertensive peak with SBP&gt; 180 and/or DBP&gt;110 and/or hypertensive crisis with BP&gt;190/90 mmHg or 175/115 mmHg); women who are pregnant at the time of collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-4vpwkg	Effects of carbohydrate mouth rinsing in the physical performance of cyclists	Recruitment completed	Intervention	2017-01-11	<NULL>	<NULL>	1145	Effects of carbohydrate mouth rinsing on physiological variables and physical performance during a cycling test	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-15	Departamento de Educação Física da Universidade Federal do Rio Grande do Norte	Departamento de Educação Física da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4vpwkg	<NULL>	individuals adult; males; aged 18 and 45; report weekly training cycling at least five hours per week.	smokers participants; obese; previously diagnosed with chronic diseases; history of musculoskeletal injuries that interfered with his training routine in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-7x429s	Effects of Cardiac Rehabilitation and Respiratory Capacity and Physical Behavior of Oxygen Consumption in Cardiac Patients	recruiting	Intervention	2013-03-05	<NULL>	<NULL>	173	Effects of Cardiopulmonary Rehabilitation on Exercise Tolerance Time (Tlim) and Oxygen Uptake Kinetics in Ischemic Heart Disease	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Hospital do Coração - HCor - Instituto de Ensino e Pesquisa (I.E.P.)	Comitê de Ética em Pesquisa da  Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7x429s	<NULL>	Patients with ischemic cardiomyopathy with an ejection fraction of the left ventricle than or equal to 35% of both sexes. The minimum age of 18 years and maximum 90 years.	Functional limitations not related to the cardiovascular system. Such as disabling lung diseases and tumors of advanced degree.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-32vrj6	Effects of Cardiac Rehabilitation on Exercise Tolerance, Endothelial Function, Heart Variability and Quality of Life in Heart Transplants.	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1778	Effects of Cardiac Rehabilitation on Functional Capacity, Endothelial Function, Cardiac Variability and Quality of Life in Heart Transplant recipients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Pernambuco-UFPE	Universidade Federal de Pernambuco-UFPE	https://ensaiosclinicos.gov.br/rg/RBR-32vrj6	<NULL>	Individuals with an age range greater than 18 years and less than 65 years of age; of both sexes; who underwent heart transplant surgery in a superior period for 6 months; with clinical stability; using regular immunosuppressive therapy, with no change in class of medications within three months prior to the start of the study	Patients who present with orthopedic, neurological or respiratory diseases that may make it impossible to perform cardiopulmonary and exercise tests; patients who are undergoing dialysis; and those patients who present psychic alterations that restrict them to respond to the questionnaires and the elderly who carry out the test Time up and go in time greater than 20 seconds, characterizing risk of falls	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-5khzxz	Effects of cardiorespiratory, resistance and core training on neuromuscular variables, pain perception, stress, and biochemical markers in adults with low back pain: a randomized clinical trial	Not yet recruiting	Intervention	2020-09-24	<NULL>	<NULL>	4923	Cardiorespiratory, Counter-Resistance and Core Training in adults with low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5khzxz	<NULL>	Have a perception of low back pain equal to or greater than 4 on the visual analog pain scale VAS; have medical clearance.	Are undergoing or have undergone less than 4 months of physiotherapeutic treatment involving strength and / or flexibility training; the pain is caused by trauma; who have high blood pressure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-35q38yx	Effects of cardiovacular and metabolic rehabilitation during dialysis with or without respiratory muscles training.	Recruiting	Intervention	2025-02-18	<NULL>	<NULL>	7763	Effects of a conventional versus adapted intradialytic cardiovascular and metabolic rehabilitation program with inspiratory muscles training: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande no Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-35q38yx	<NULL>	Subjects over eighteen years of age will be included with no maximum age limit; both genders; diagnosed with stage five Chronic Kidney Disease for at least three months; undergoing hemodialysis at the Santa Rita Nephrology Center at least twice a week	Those who have some degree of neurological impairment will be excluded; who already undergo physiotherapeutic treatment; do not have the ability to walk independently; that they are bedridden; who are unable to carry out the evaluative tests and physiotherapeutic procedures proposed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-2fr526n	Effects of cell therapy with mesenchymal stem cells and platelet-rich plasma in the treatment of knee osteoarthritis	Data analysis completed	Intervention	2021-11-16	<NULL>	<NULL>	5050	Effects of cell therapy with mesenchymal stem cells from adipose tissue and platelet-rich plasma in the treatment of osteoartrite that was not responsive to drug treatment	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-29	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2fr526n	<NULL>	Volunteer individuals were included; diagnosed through physical assessment; be classified by imaging with osteoarthritis grade II to IV; who already had an indication for knee surgery; patients unresponsive to conservative treatment (physical and drug) commonly used in the Unified Health System (SUS) for at least 6 months.	Individuals with extreme deformities of the knee joint were excluded; who reported having hemophilia, anemia, gastrointestinal diseases, cancer, thyroid, liver, and previous nephrological disorders and HIV; patients who were chronically using immunosuppressive and anticoagulant drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-738zkp7	Effects of cerebral stimulation during treadmill training on gait in people with Parkinson&apos;s disease	Not yet recruiting	Intervention	2022-07-04	<NULL>	<NULL>	5462	Effects of transcranial direct current stimulation combined with treadmill training on gait in people with Parkinson&apos;s disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro	Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro	https://ensaiosclinicos.gov.br/rg/RBR-738zkp7	<NULL>	Subjects with diagnosis of idiopathic Parkinson&apos;s disease given by a private neurologist, according to the London Brain Bank criteria.	Subjects with another neurological disease in addition to Parkinson&apos;s disease; subjects in stage above of 3 on the adapted Hoehn &amp; Yahr scale; subjects with characteristics that make transcranial direct current stimulation risky (neural implants, history of seizures, pacemaker, epilepsy); history of orthopedic and/or vision problems that make it impossible to comply with experimental procedures; indicative of dementia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-6dwmkx	Effects of cervical exercises in individuals with temporomandibular disorders	Recruiting	Intervention	2020-07-29	<NULL>	<NULL>	4064	Effects of a control neck exercise program in individuals with temporomandibular disorders: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-15	Universidade Estadual de Campinas	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-6dwmkx	<NULL>	All volunteers must: be between 18 and 55 years old; diagnosis of muscle TMD according to RDC / TMD (Ia and Ib); bilateral TMJ dysfunction; have pain and / or tiredness in the masticatory muscles during functional activities for more than 3 months and; present Body Mass Index (BMI) between 18 and 25 kg / m2. The volunteers should present moderate pain intensity in the chewing muscles during chewing, being represented by a value greater than or equal to 4 cm according to VAS.	Women who have dental failure, open bite, crossbite, full or partial dentures, neuromuscular systemic diseases, history of trauma to the face and / or TMJ, joint dislocation, are undergoing orthodontic and / or drug treatment that affects the musculoskeletal system. in pregnancy, and / or who have a whiplash, previous surgery on the cervical spine, and a diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-8nxn75	Effects of Cervical Manipulation on Upper Limb Motor Control in Subjects with Neck Pain	Data analysis completed	Intervention	2013-08-26	<NULL>	<NULL>	236	The Effect of Motor Control Deficits and Physical Therapy Interventions on the Grip Force Control	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-10	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8nxn75	<NULL>	History of three or more neck pain episodes in the past three months.	Previous history of rheumatic disease, cervical myelopathy, tumors, central or peripheral neurological disorders. History of major trauma, fracture or surgery in the neck, shoulder and/or upper limb. Signs of nerve root compression as important muscle weakness affecting the upper limbs, reduction or loss of biceps and triceps reflexes, decreased sensation in the dermatomes of the upper limb. Red flags contraindicating cervical manipulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-4y7yyfs	Effects of circuit strength training on exercise energy expenditure, appetite, and food intake in post-stroke patients with partial body part paralysis	Recruiting	Intervention	2021-11-03	<NULL>	<NULL>	5014	Acute effects and reproducibility of circuit resistance training session on energy expenditure, appetite and energy intake in patients with stroke sequelae	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-05	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4y7yyfs	<NULL>	Right or left hemiparesis, with at least six months of the occurrence of stroke; be able to walk without supervision for home walking; enrolled in a neuro-motor rehabilitation program; score above 36 on the Berg balance scale; minimum score of 50 on the Fulg-Meyer scales; signature of the written informed consent form.	Smoking; history of drug or alcohol abuse; using beta-blockers, neuroleptics or medications that alter the threshold excitement of the neuronal membrane; hormone replacement therapy; head trauma; metallic prosthetic device in the skull; evidence of secondary hypertension; diagnosed with metabolic, liver, cardiac, oncological, psychiatric, neurological pathologies; body mass index &lt;25 or&gt; 35 kg / m2. g) Estimated glomerular filtration rate &lt;60 mL/min; h) Acute or chronic hepatic disease with transaminases &gt;3x upper reference value; i) Patients with clinical evidence of coronary disease with a history of angina or tests compatible with myocardial ischemia; j) Previous history of acute myocardial infarction and/or myocardial revascularization; k) Clinical signs of heart failure, symptomatic cardiac arrhythmia or clinically significant valve disease; l) Patients with a history of drug or alcohol abuse in the last 10 years; m) Patients with a history of cancer in the last five years; n) History of neurological or psychiatric disease (e.g. epilepsy); o) History of cranial trauma at any age or existence of a metal prosthetic device or other metal particle in the skull.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-5r4s3tp	Effects of Circuit Training on the physical and functional  fitness of elderly people	Recruiting	Intervention	2026-02-24	<NULL>	<NULL>	8909	Effects of the Mixed Circuit at High-Speed and Short Duration on indicators of physical complexity and functionalities in elderly individuals	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-03	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Older adults aged 60 years or older; both sexes; referred by the Open University for Older Adults of the State University of Rio de Janeiro; presenting good clinical health status; ability to perform activities of daily living independently; eligible for participation in physical exercise after pre-exercise screening	Presence of uncontrolled cardiovascular, respiratory, neurological, musculoskeletal, or metabolic diseases that contraindicate physical exercise; musculoskeletal limitations that prevent safe execution of the proposed exercises; use of medications or clinical conditions that pose risk during physical exercise; cognitive impairment that prevents understanding and execution of study procedures; concurrent participation in a structured physical training program	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-4p5b4xb	Effects of circuit-based resistance training on frailty and functional capacity in older adults	Recruitment completed	Intervention	2026-04-24	<NULL>	<NULL>	9133	Circuit Resistance Training: an intervention model to improve functional capacity and frailty status in older adults	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Participants must not have engaged in any structured physical activity over the past year; must self-identify as female or male; must be aged 60 years or older; must live near the Sports Center where the experiment will be conducted; must agree to participate only in the intervention as their daily physical practice during the 12-week period; must score between 1 and 5 on the criteria used to assess frailty status; and must be able to complete the Informed Consent Form in accordance with Brazilian National Health Council (CNS) Resolution No. 466/2012, as well as be fit to participate fully in the study	Older adults presenting with severe frailty; severe and unstable clinical conditions (cardiovascular, respiratory, neurological, or orthopedic) within the last month and at the time of recruitment/intervention; cognitive impairment that prevents understanding the Informed Consent Form (ICF) and following instructions; recent falls with serious injuries and/or postural instability that precludes exercise practice; rapid and excessive weight loss; participants who have engaged in structured physical activity within the last 12 months; dependence on mobility aids that may hinder performance of the training; participation in other studies; refusal to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-5x9434h	Effects of Class II Treatment with Orthodontic Aligners associated with Mandibular Advancement or the use of Intraoral Distalizers	Recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7698	Effects of Class II Treatment with Orthodontic Aligners associated with Mandibular Advancement or Intraoral Distalizers: multicenter randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Universidade Anhaguera - UNIDERP	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-5x9434h	<NULL>	Age between 10 and 14 years; both sexes; at least half Class II of Angle; convex facial profile, characterizing mandibular retrognathism; pronounced horizontal overjet, greater than 4 mm	Presence of craniofacial deformities; dental agenesis; active carious lesions; and previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-8yfq4g	Effects of classic mat pilates exercises performed on the ground, with Ballet Barre exercises, performed standing, on postural control strategies.	Recruiting	Intervention	2019-10-30	<NULL>	<NULL>	3154	Effects of regular lumbopelvic stability exercise on postural control strategies	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2019-09-30	Universidade de São paulo	Universidade de São paulo	https://ensaiosclinicos.gov.br/rg/RBR-8yfq4g	<NULL>	Inclusion criteria over 19 years;  low back pain for at least 12 weeks; pain scale between 3 and 7 by the Rolland-Morris questionnaire.	"As exclusion criteria medical contraindication that presents some risk; physical and / or mental disability; fracture; or serious soft tissue injury in the 6 months prior to the study; as well as history of neurological; cardiovascular or respiratory alterations; vestibulopathies and peripheral neuropathy; high blood pressure; diabetes or any uncontrolled chronic disease. Being in rehabilitation treatment (acupuncture; physical therapy; global posture rehabilitation; pilates; yoga and others).
Individuals with low back pain classified as &quot;severe disability&quot;; according to the questionnaire translated and validated in Portuguese Rolland Morris; whose sum is equal to or greater than 14 points; which indicates severe disability. (Mascarenhas, 2011)
Unwillingness to complete study requirements;  or to be randomized into intervention groups; more than two absences."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-2gykb2	Effects of clown intervention on the psychological stress and fatigue in children and adolescents with cancer receiving chemotherapy	Recruiting	Intervention	2016-07-14	<NULL>	<NULL>	924	Correlations between immunological biomarkers and response to fatigue and psychological stress in children and adolescents with cancer undergoing chemotherapy submitted to clown intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-12	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gykb2	<NULL>	Experimental group;Children and adolescents aged 2 to 18 years; of both sexes; diagnosed with malignant neoplasm; in any phase of chemotherapy; who present conscious, able to communicate verbally, reading and writing; Control group;Children and adolescents aged 2 to 18 years; with no history of chronic disease or autoimmune disease or psychiatric illness; followed up in one of the 5 Family Health Unitis; not be receiving medication at the time of selection or collection of biological samples; who present conscious, able to communicate verbally, reading and writing; presenting recent blood count data in normal levels;	Experimental group;Patients with a history of chronic disease or autoimmune disease or psychiatric disease; patients receiving radiotherapy; patients in palliative care; patients using antidepressants or drugs which altering the mood; patients with clownfobia; patients with infectious conditions in activity; patients in the immediate postoperative period; Control group;Children and adolescents with infectious conditions in course; presence of fever in the last 48 hours; in use of systemic corticosteroids, inhaled or topical in the last 15 days;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-5s9bhc	Effects of coconut oil intake on high blood pressure	Recruitment completed	Intervention	2020-08-20	<NULL>	<NULL>	4143	Effects of coconut oil supplementation on blood pressure in hypertensive patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-13	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5s9bhc	<NULL>	Volunteers of both genders; mild hypertensive patients aged between 18 and 65 years.	Volunteers with secondary hypertension; volunteers under pharmacological treatment or using hormone therapy; with a recent history of emergency hospitalization due to the hypertensive crisis; Diabetes Mellitus; and volunteers with pressure levels outside the range of stage I hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-66n5c5r	Effects of Cognitive Behavioral Couple Therapy combined with Mindfulness on mindful attention, depressive symptoms and dyadic adjustment: A randomized clinical trial	Data analysis completed	Intervention	2022-01-25	<NULL>	<NULL>	5166	Cognitive Behavioral Couple Therapy Combined with Mindfulness	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Universidade Metodista de São Paulo	Universidade Metodista de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66n5c5r	<NULL>	age between 18 and 60 years; being in a heterosexual relationship; Portuguese as their mother tongue; literate and having education level up to complete higher education; having one or more year of marriage or cohabitation; to present conflict in the relationship related to communication difficulties (we used the Romantic Partner Conflict Scale adapted); naive practitioner in the Mindfulness meditation exercise; monthly income per family up to R$6,000,00; having consent of both spouses to participate in the study.	Having any severe clinical psychological disorder; being drug addict or taking psychiatric medication (we used the interview, the Alcohol, Smoking, and Substance Involvement Screening Test - ASSIST, and the General Health Questionnaire - GHQ-12).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-2gjxb8	Effects of Cognitive Therapy of motor learning for children with cerebral palsy	Recruitment completed	Intervention	2016-06-16	<NULL>	<NULL>	895	Effects of Cognitive Orientation to daily occupational performance (CO-OP) for children with cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-15	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - Universidade Federal de Minas Gerais	Ministério da Ciência, Tecnologia e Inovação - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-2gjxb8	<NULL>	Children with cerebral palsy; aged 7 and 14; classified by the Classification System of the Gross Motor Function (GMFCS) levels I or II; sorted by System Manual Function Classification (MACS) in levels I, II and III have cognitive skills to understand commands and verbal communication and attending occupational therapy visits with weekly frequency.	Children who have some visual impairment and / or hearing; children who have been subjected to the use of botulinum toxin and / or orthopedic surgery in the six months preceding the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-6nw7p8	Effects of cold water immersion after crossfit® practitioners: randomized, blind, controlled clinical trial	Recruiting	Intervention	2020-07-09	<NULL>	<NULL>	3990	Effects of cold water immersion on recovery of indirect markers of muscle damage in crossfit® practitioners: randomized, blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6nw7p8	<NULL>	"Men and women, CrossFit® practioners;
age between 18 and 40 years old;
at least 6 years of regular physical practice;
practice CrossFit® at least 3 times a week;
have performed at least twelve WOD&apos;s the last 4 weeks;
have experience in Karen WOD;
do not have performed a Karen WOD the last 4 weeks; 
have participated in some Mixed Modalities Training competition (at least at local level);
do not present osteomyoarticular injury that prevent the WOD from being performed;
do not present cardiomyopathy, muscular dystrophy, neurological disease;
do not present pain in the lower limbs;
do not have hypersensitivity or ice allergy;
do not have Raynaud syndrome;
be in the period immediately after menstruation, in the follicular phase of the menstrual cycle (only for female participants)"	"Could not complete the exercise protocol in the assessment;
do not complete any of the study procedures for any reason;
make use of energy drinks, anabolic steroids, drugs, among other substances that can increase performance during the assessment period;
make use of analgesic, anti-inflammatory or central nervous system depressants during the research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-2bz8rj	Effects of cold water immersion after exercise	Recruitment completed	Intervention	2015-01-23	<NULL>	<NULL>	375	Immediate and delayed effects of cold water immersion after eccentric exercise protocol	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-20	Universidade Estadual Julio de Mesquita Filho	Universidade Estadual Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-2bz8rj	<NULL>	Male; apparently healthy; physically active	Be alcoholics; drug use; smoking or anti-inflammatory medications chronically; present anemia; inflammation; diabetes; cardiovascular disease; liver problems; injury episode musculotendinous osteoarticular or lower limbs and / or spine in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-67qgm2	Effects of cold water immersion on clinical, functional and performance parameters in swimming athletes	Recruitment completed	Intervention	2019-03-28	<NULL>	<NULL>	2559	Effects of systematized application of cold water immersion on clinical, functional and performance parameters in swimming athletes - a randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-07	Universidade Estadual Paulista	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-67qgm2	<NULL>	"Athlete of the swimming team of SEMEPP (Municipal Secretary of Sports of Presidente Prudente);
Train regularly 6 days a week;
Be aged between 12 and 20 years;
Do not present previous musculoskeletal injury or disease that makes it impossible to train."	Provide injury or illness during the period of research that moves away from training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-688c6mb	Effects of combination of the application of Electric Current and Massage on bruxism	Recruiting	Intervention	2022-11-24	<NULL>	<NULL>	5746	"Effects of Electromassage in adults with bruxism: a randomized clinical trial
controlled"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-688c6mb	<NULL>	Volunteers of both sexes; between 18 and 40 years of age; with a diagnosis of problable bruxism that will be based in the presence of a positive result in the self-report and clinical odontological inspetion	Participants under the age of 18; who do not agree to participate in this study or who have cognitive deficit determined by the MMSE questionnaire - Mini Mental State Examination; hearing deficit that prevents understanding of verbal instructions; neuromuscular disorders and/or trauma-orthopedic conditions that prevent the participant from carrying out the assessments and/or proposed intervention; pregnant or lactating women; individuals diagnosed with cancer and autoimmune diseases; present other associated osteoarticular disorders at the application site; have severe symptoms of depressive disorders and/or anxiety disorders, alcohol and/or drug abuse; daily use of pain control medication (as preventive medication for the treatment of chronic tension headache and/or migraine); present tooth loss of more than two posterior teeth, except third molars; who are on concomitant treatment for bruxism; users of occlusal splints, complete dentures, removable partial dentures and orthodontic appliances; who have not taken at least the first dose of the Covid-19 vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-46p3q6b	Effects of Combined Cycling and Weight Training on the response to treatment of patients with Bowel Cancer that has spread to other organs: contribution of substances released by the muscle	Recruiting	Intervention	2025-01-06	<NULL>	<NULL>	7638	Effects of Combined Aerobic and Resistance Training on the response to chemotherapy in patients with Metastatic Colorectal Cancer: contribution of microRNAs	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Escola de Educação Física e Esporte da Universidade de São Paulo	Conjunto Hospitalar de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-46p3q6b	<NULL>	Patients aged 18 years or older; recent diagnosis of stage IV colorectal cancer, with measurable lesion and available and proven biopsy; candidates for chemotherapy sessions; Performance Status Scale (Eastern Cooperative Oncology Group - ECOG) between 0 and 2	Presence of unstable (uncontrolled) comorbidity; presence of dementia (score &lt;23 on the Mini Mental State Examination); having participated in a physical training program in the last 6 months; having active infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-2pmkjw7	Effects of Combined Exercise Training before treatment in women with Breast Cancer	Recruiting	Intervention	2024-02-17	<NULL>	<NULL>	6792	Combined physical training for women undergoing oncology care at CAISM Mastology	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti. Universidade de Campinas - UNICAMP	Escola de Educação Física e Esporte - EEFE. Universidade de São Paulo - USP.	https://ensaiosclinicos.gov.br/rg/RBR-2pmkjw7	<NULL>	Women diagnosed with invasive breast carcinoma;  age greater than or equal to 18 years; disease stage within I to III	Having undergone previous treatment for cancer; having actively participated in a structured physical training program for a minimum duration of 6 months; self-report inability to engage in physical exercise; medical contraindications for physical exercise; and pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-4fr2gf	Effects of combined exercises among individuals with radiating low back-related leg pain	Recruiting	Intervention	2017-11-07	<NULL>	<NULL>	1467	Effects of neurodynamic exercises addition to extension-oriented treatment approach among individuals with low back-related leg pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4fr2gf	<NULL>	Eligible patients may be between 18 and 65 years of age; have radiating pain into one leg below the gluteus for at least 12 weeks with low back pain; mild to severe function limitation; positive SLR test; sufficient understanding to describe signs and symptoms and to answer the specific questionnaires.	Patients will be excluded if they be pregnant; have serious spinal pathology; have exercise contra-indications; have history of lumbar surgery; have severe metabolic or cardiovascular pathology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-6bc29xw	Effects of combined physical training on the response to chemotherapy in patients with metastatic colorectal cancer	Recruiting	Intervention	2026-04-19	<NULL>	<NULL>	9118	Effects of combined physical training on the response to Chemotherapy in patients with Metastatic colorectal cancer: responses of the Autonomic nervous system	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients aged over 18 years old; both sexes;recent diagnosis of colorectal cancer at any stage (new cases) for Crosssectional I and II, and for the longitudinal study, patients with metastatic colorectal cancer with measurable lesions and available and verified biopsy;candidates for chemotherapy sessions (Crosssectional II and Longitudinal);undergoing the first cycle of chemotherapy (Cross-sectional II);performance Status Scale (ECOG- Eastern Cooperative Oncology Group) between 0 and 2;no dementia (score less than 23 on the Mini-Mental State Examination);not having participated in a physical training program in the last 6 months (Longitudinal);no active infections at the time of inclusion in the studies	Patients with uncontrolled comorbidities;patients with cognitive or mental limitations: they may have difficulty understanding and adhering to treatment, requiring additional support;patients with a history of substance abuse: substance use can complicate pain management and symptom control, as well as affect adherence to treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-4tzrdjz	Effects of combining different types of physical and cognitive Exercises on brain health in the elderly	Terminated	Intervention	2026-01-26	<NULL>	<NULL>	8799	Effects of different modalities of Dual Task Physical Exercise on the brain health of elderly people	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-04	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Elderly individuals from local health units and the community; aged 60 years or older; of both sexes; capable of independent ambulation; with medical authorization to practice exercise; literate (able to read and write); able to understand verbal instructions for performing the tests; accessible to participate in training; and with a score &gt;17 on the Montreal Cognitive Assessment (MoCA)	Diagnosis of dementia; participation in a physical exercise program in the three months prior to the start of the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-4vr87t	Effects of combining Dry Needling and Therapeutic Ultrasound on the treatment of neck muscle tension points	Recruitment completed	Intervention	2019-09-30	<NULL>	<NULL>	3012	"Effects of the combination of Dry Needling and Therapeutic Ultrasound on the treatment of
Trigger Points in the upper trapezius muscle"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Centro Universitário de Anápolis	Centro Universitário de Anápolis	https://ensaiosclinicos.gov.br/rg/RBR-4vr87t	<NULL>	Young adults with active or latent trigger point (PG) in the upper trapezius muscle aged between 18 and 50 years old; with complaints of pain over three months were included. To confirm the diagnosis of myofascial PG; the following criteria were require; a palpable tense band in the upper trapezius muscle; range of motion limitation; a point sensitive to palpation and pain referred local or in specific areas according to the evaluated muscle	Participants diagnosed with fibromyalgia; radiculopathy; myelopathy; cervical vertebral fractures; needle phobia; coagulation disorder; muscular derelaxants; and physical therapy in the last three months in the cervical region will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-1024hsqk	Effects of combining Physical Literacy with a Physical Activity and Pain Education intervention for Older Adults with Chronic Pain in Muscles, Bones, and Joints	Recruiting	Intervention	2025-10-10	<NULL>	<NULL>	8387	Effect of integrating Physical Literacy into a Physical Activity and Pain Education intervention for Older Adults with Chronic Musculoskeletal Pain: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Estadual Paulista	Universidade Federal de Sâo Carlos	https://ensaiosclinicos.gov.br/rg/RBR-1024hsqk	<NULL>	"Age 60 years or older; Experience of persistent musculoskeletal pain for six months or more;
Independent walking; Receiving care from the Primary Health Care Unit in São Carlos, SP"	Suspected serious health conditions, as described in the literature, that may be associated with chronic musculoskeletal pain (CMP) and require medical referral, such as suspected fractures, cancer, progressive neurological deficits, or infection; Musculoskeletal, neurological, or cardiovascular conditions that may be worsened by exercise, according to healthcare professionals’ judgment, preventing participation in group physical activity; Cognitive impairment that prevents the older adult from answering interview questions and questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-7zccgr	Effects of complementary therapies associated with Cardiac Rehabilitation in patients with Chronic Heart Failure	Not yet recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2176	Effects of Noninvasive Ventilation and Inspiratory Muscle Training associated with Cardiac Rehabilitation in the kinetics of oxygen consumption in patients with Chronic Heart Failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte- UFRN	https://ensaiosclinicos.gov.br/rg/RBR-7zccgr	<NULL>	The patients present a diagnosis of stable chronic Heart failure who are undergoing medical follow-up with a cardiologist and present stable disease suggested by the absence of any change in medication and without previous diagnosis of moderate or severe chronic obstructive pulmonary disease, exercise-induced asthma and previous hospitalization history last 3 months and anginal events in the three months before the study, with left ventricular systolic dysfunction with LVEF &lt;40% and New York Heart Association (NYHA) classification in classes II and III.	Patients with musculoskeletal diseases or any other situation that makes it impossible to perform aerobic or resisted exercises. To present worsening of signs and symptoms of HF after starting the proposed rehabilitation program. Present paradoxical breathing or persistent use of accessory breathing muscles or oxygen desaturation during the exercise program. Body mass index (BMI) &lt;35 kg / m. Any individual with severe, significant arrhythmias or unable to perform the exercise protocol associated with Non- invasive ventilation (NIV) or Respiratory Muscle Training (RMT) will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-3jy7kg	Effects of Constraint Induced Moviment Therapy associated with Elastic Bandage in the upper-extremity of patients with loss of acute or chronic motion	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1556	Effects of Constraint Induced Moviment Therapy associated with Funcional Bandage in the upper-extremity of acute and chronic hemiparetic patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3jy7kg	<NULL>	Hemiparetic individuals in upper limb; both genders; 5 to 60 years; Signature of the Informed Consent Form (TCLE); diagnosis of neurological injury; minimum motor criterion for the execution of the TCI; without cognitive deficit.	Allergy to Functional Bandage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-6g5ys67	Effects of consuming orange juice with a high-fat meal on metabolism	Data analysis completed	Intervention	2026-02-25	<NULL>	<NULL>	8906	Effects of orange flavonoid intake associated with a high-fat meal and their impact on advanced glycation end products (AGEs) concentrations	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18 and 30 years; no diagnosed illnesses; not using any medication; not vegan or vegetarian; and no smoking habits.	Smokers; individuals with chronic non-communicable diseases; obese individuals (BMI greater than or equal to 30 kg/m2); individuals with cardiovascular disease and kidney disease; vegetarians/vegans; and breastfeeding mothers.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-526tmt3	Effects of Contensive Taping in the immediate postpartum cesarean: a clinical study	Recruiting	Intervention	2025-10-14	<NULL>	<NULL>	8410	Evaluation of Contensive Taping in post-cesarean recovery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade do Estado de Minas Gerais Unidade Divinópolis	Universidade do Estado de Minas Gerais Unidade Divinópolis	https://ensaiosclinicos.gov.br/rg/RBR-526tmt3	<NULL>	Postpartum women over 18 years of age; who underwent cesarean delivery from 1 to 7 days postpartum; and who did not experience any type of complication during delivery	Women with twin pregnancy; gestational diabetes and preeclampsia; those with complications related to the surgical wound, such as dehiscence and infection; those with hemorrhage, deep vein thrombosis, any other active infections, fever, dehydration, dizziness, and fainting	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-3tykzt	Effects of continuous aerobic and interval exercise in patientes with heart failure	Recruiting	Intervention	2015-09-17	<NULL>	<NULL>	617	Effects of continuos aerobic and interval trainin in function cardiopulmonary in patients with heart failure: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-3tykzt	<NULL>	Cardiologist forward with diagnosis confirmed by clinical and complementary test (echocardiogram); Patient with Functional Class I, II and III HF according to the New York Heart Association (NYHA); 20 ejection fraction to 53% by echocardiography detects the last 6 months; Both genders; Clinical stability; Heart Failure compensated; Spirometry with FEV1 / FVC&gt; 80%; Cardiac pacemaker absence. In addition, patients may not perform training or physical activity elsewhere.	Decompensated heart failure development; CPET or arrhythmias during exercise identified by clinical and / or ECG changes; unstable angina; embolism; acute systemic infection; Lock 3rd degree AV (without pacemaker); pericarditis or acute myocarditis; uncontrolled arrhythmias; ST-segment depression&gt; 2 mm during the year; HF with normal systolic function (ejection fraction&gt; 53%); Class D (red) in the stratification of risk for adverse cardiac events while performing physical exercise; uncontrolled diabetes mellitus; Myocardial Revascularization need for surgical or other procedure; lack of understanding of the activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-45kmbp	Effects Of Continuous Current In Shadows And Quality Of Life In Women With Primary Hyperidrosis	Not yet recruiting	Intervention	2020-03-19	<NULL>	<NULL>	3634	Direct current aApplication in the treatment of hyperhidrosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-45kmbp	<NULL>	Female volunteers, aged 18 to 300years old, who had primary hyperhidrosis without ever having received previous treatment for this chronic disease (treatment).	Male patients, patients with sensitivity to electric current, patients with dermatological damage, heart problems, pregnant women, diabetics or those with uncontrolled hypertension, as well as those with neoplasms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-5qkm8k	Effects of cooling on perception of pelvic muscles in women with urinary incontinence	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2733	Effects of cryotherapy on the proprioception of pelvic floor muscles in women with urinary incontinence: a randomized, blind, crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-04	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5qkm8k	<NULL>	Accept participate in the research and sign the Free and Informed Consent Form; Be 35 or older; Have a complaint of Urinary Incontinence; Not having undergone physiotherapeutic treatment for Urinary Incontinence.	Being overweight; Have allergy to latex and / or ice; Being with a urinary or vaginal infection; Have pelvic organ prolapse greater than grade II; To present cognitive and neurological disorders, uncontrolled arterial hypertension or inability to perform the evaluation; Make use of hormone replacement therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-47fqzk	Effects of Counseling in sedentary adults with ankylosing spondylitis	Recruiting	Intervention	2016-07-22	<NULL>	<NULL>	936	Evaluation of effects hacer sin Sedentary behavior counseling Adults with ankylosing spondylitis : a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-47fqzk	<NULL>	"Having diagnosis of ankylosing spondylitis, according to the criteria New York.
Age between 18 and 59 years.
Male."	"Be diagnosed with some form of physical or mental disability.
Patients on medications that alter bone metabolism , such as denosumab , teriparatide , strontium ranelate.
Patients with bone fracture history in the last 6 months.
Patients with metabolic bone diseases and / or diseases that alter bone metabolism , including hyperparathyroidism , chronic renal failure , metabolic acidosis and alteration of serious levels of calcium, phosphorus and magnesium. 
Patient presenting chronic decompensated and medical negative for physical activity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-65qxs2	Effects of COVID-19 on pregnancy, childbirth, puerperium, neonatal period and child development: prospective, multicenter cohort study	Recruiting	Observational	2020-09-17	<NULL>	<NULL>	6531	Effects of COVID-19 on pregnancy, childbirth, puerperium, neonatal period and child development: prospective, multicenter cohort study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Hospital Universitário de Brasília	Hospital Regional da Asa Norte, Secretaria de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-65qxs2	<NULL>	"Exposed women: Data from the mandatory positive results registration center (Directorate of Epidemiological Surveillance - DIVEP) will be consulted and telephone contact will be made with all women between 18 and 40 years old with a positive test for SARS-CoV-2. For those who report being pregnant, prenatal care will be offered at the University Hospital of Brasília (in an outpatient clinic created specifically for this purpose), as well as childbirth assistance at that hospital. Recruitment will end when it reaches 300 women. Unexposed women: During the months of the study, serology to detect anti-SARS-CoV-2 antibodies (IgG and IgM) and RT-PCR for SARS-CoV2 will be offered to all women admitted for childbirth assistance at the University Hospital of Brasilia. Those with negative tests for COVID 19 and who consent to participate in the study, will be offered Growth and Development monitoring for their children at the Pediatric Service of the Hospital Universitário de Brasília, up to the age of five, in an outpatient clinic created specifically for this purpose . Recruitment will end when reaching n 300 of unexposed women. Exposed newborns: the sample will consist of the children of women infected with SARS-CoV-2 in the different stages of pregnancy, which formed the sample of exposed women. Exposed newborns: group represented by unexposed newborns who are infected in the neonatal period. Upon diagnosis, they will become part of the group of newborns exposed for pediatric follow-up purposes.
Recruitment will end when it reaches n 300 children (newborns and neonates) exposed. Newborns not exposed: the sample will consist of the children of women who made up the group that were not exposed and who remain with negative serology until the end of the neonatal period. Recruitment will end when reaching n 300 unexposed children"	Women exposed and not exposed to SARS-CoV2 infection during pregnancy: pre-existing chronic diseases that require continuous use of medications, except diabetes and hypertension; smoking and / or alcoholism; suspicion or confirmation of other congenital infections such as toxoplasmosis, syphilis, rubella, herpes, Chagas and zika; impossibility of sequential follow-up until delivery. Newborns exposed and not exposed to intrauterine SARS-CoV2 infection: evidence or confirmation of genetic syndromes; suspicion or confirmation of other congenital infections, such as toxoplasmosis, syphilis, rubella, herpes Chagas and zika; impossibility and sequential follow-up until the age of five.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-973w9d	Effects of cranial sacral therapy associated with mobilization of the uterus to relieve menstrual cramps	Data analysis completed	Intervention	2020-09-18	<NULL>	<NULL>	4254	Skull sacral and uterine mobilization to relieve primary dysmenorrhea	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-03-11	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-973w9d	<NULL>	Women enrolled in the higher education institution - FIS; Age between 20 and 28 years; Clinical diagnosis of dysmenorrhea in her pre-menstrual and menstrual period.	Amenorrhea; Alcoholism; Smoking; Pregnancy; Hysterectomy; Endometriosis; Polycystic ovary syndrome; Myoma; Ovarian cysts; Congenital malformations of the urinary tract; Cervical stenosis; Gynecological consultation for over a year; Make use of Intrauterine Device - IUD; Women using analgesic drugs or muscle relaxants; Women using any other therapy to treat primary dysmenorrhea and associated symptoms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-6dq7tz	Effects of crustacean oil supplementation on lipid profile and inflammatory markers in overweight women	Recruitment completed	Intervention	2020-03-11	<NULL>	<NULL>	3609	Effects of supplementation with Krill Oil on lipid profile and inflammatory markers in women with overweight	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-10-25	Gustavo Duarte Pimentel	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6dq7tz	<NULL>	Adult women, aged 20 to 59 years and BMI &gt;25 kg / m2.	Elderly and adult women diagnosed with: kidney disease; cardiovascular; hepatic; cancer; pregnant women; lactating; chronic drinkers; using anti-inflammatory drugs or affecting appetite or body weight; in an inflammatory or infectious process on the day of collection or in the previous seven days; who participated in any food restriction program or following a specific diet, using dietary supplements in the last six months and intolerant or allergic to seafood in general.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-10d8nkrv	Effects of Cryofrequency on Facial Rejuvenation	Data analysis completed	Intervention	2025-12-23	<NULL>	<NULL>	8680	Effects of Cryofrequency on the Treatment of Facial Skin Aging Signs	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-07	Universidade Estadual de Goiás	<NULL>	<NULL>	<NULL>	Women over 35 years of age; who present facial characteristics of aging such as fine dynamic and static wrinkles; sagging and loss of facial tone; who seek the services and aesthetics of the Aesthetics and Cosmetology course at the State University of Goiás and agree to participate in the study	Women who have undergone recent cosmetic treatment (within the previous 6 months); those with a history of abnormal scarring (keloid or hypertrophic scar); inflammatory skin disease; cardiovascular disease; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10fg77vk	Effects of cupping therapy on pain intensity, fatigue and performance after a 10km run	Not yet recruiting	Intervention	2022-01-28	<NULL>	<NULL>	6197	Effects of sliding cupping therapy on pain intensity, fatigue perception and muscular performance after a 10km run	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-05	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	Caio Alano de Almeida Lins	https://ensaiosclinicos.gov.br/rg/RBR-10fg77vk	<NULL>	"Street runners for at least 1 year who run twice a
week; Being able to run 10 km continuously in the time interval between 40 and 60 minutes in at least one training session; Be between 18 and 45 years old; Not present severe cardiorespiratory or metabolic alterations, proven by a medical report; Not reporting the presence of musculoskeletal disorders in the lower limbs, in the last 6 months, that have prevented the maintenance of the training routine; Do not report any of the contraindications for the application of cupping therapy; Never having used cupping therapy"	"Presenting disorders in the quadriceps femoris, such as hematoma and cramp, during
study procedures; Present allergy or skin irritation due to the use of vegetable oil necessary for cupping therapy; Not being able to complete the 10km run within 60 minutes; Failure to correctly perform the assessment procedures; Not attending any stages of collection development; Make use of anti-inflammatory drugs, corticosteroids, analgesics or muscle relaxants during the collection period or in the 30 days preceding the beginning of the study; Make use of ergogenic resources, such as anabolic steroids, in the last 6 months prior to the start of collection; Carry out another type of intervention for muscle recovery during the development of the research; Refusing to sign the Free and Informed Consent Form (ICF)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-3775776	Effects of Curcumin supplementation associated with resistance training on muscle gain, maximal strength, and blood markers in strength training practitioners: a randomized, double-blind clinical trial	Other	Intervention	2025-05-07	<NULL>	<NULL>	7989	Effects of Curcumin supplementation associated with resistance training on muscle hypertrophy, maximal strength, and biochemical biomarkers in strength training practitioners: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-21	União Brasileira de Educação e Assistência	União Brasileira de Educação e Assistência	https://ensaiosclinicos.gov.br/rg/RBR-3775776	<NULL>	Adult male bodybuilders; age 20 to 35; who have been bodybuilding for at least six months; practitioners who include at least three weightlifting physical activity sessions per week	Individuals diagnosed with any chronic disease or condition such as hypertension ; type 1 or type 2 diabetes mellitus ; as well as those using dietary supplements or medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-75ys4s9	Effects of dance on health of patients with basal ganglia disease: a randomized controlled clinical trial	Recruiting	Intervention	2023-12-28	<NULL>	<NULL>	6692	Effects of dance on the quality of life of patients with basal ganglia disease: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-75ys4s9	<NULL>	Diagnosis of affection of basal ganglia, hyper or hypokinetic; hemodynamic stability; in use of prescribed medications and medical follow-up; both genders	Hemodynamic instability; without use of prescribed medications; without medical follow-up; withdrawal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-2ds9ky9	Effects of Dance Therapy on the ability to perceive and learn movements in children with Autism Spectrum Disorder and its impact on autonomy in activities of daily living	Recruitment completed	Intervention	2023-02-07	<NULL>	<NULL>	5882	Effects of Dance Therapy on perceptive-motor skills of children with Autism Spectrum Disorder and its impact on autonomy in daily life activities	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Programa de Pós Graduação em Ciências da Reabilitação da Universidade Federal de Alfenas	Programa de Pós Graduação em Ciências da Reabilitação da Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2ds9ky9	<NULL>	Interdisciplinary Diagnosis of Autism Spectrum Disorder; Both genders; age range between 5 to 7 years old; They were under a period of social isolation; Signed the Informed Assent Term (TAE); Parents and/or guardians who consented to voluntary participation and signed the Free and Informed Consent Term (FICT)	Presence of other associated physical, neurological, psychic or psychological impairments; Showing hyperirritability to music; Have severe behavioral disorders; Already perform therapeutic intervention based on music or focusing on activities of daily living	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-296drgz	Effects of deep relaxation on pain in patients with chronic wounds	Not yet recruiting	Intervention	2023-11-20	<NULL>	<NULL>	6592	Effects of Hypnosis on pain: a clinical trial in patients with chronic wounds	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-30	Universidade do Estado da Bahia	Secretaria Municipal de Saúde de Salvador	https://ensaiosclinicos.gov.br/rg/RBR-296drgz	<NULL>	Being 18 years of age or older; both genders; have a wound that has existed for four weeks or more, and complain of moderate to severe pain	Patients with altered hearing acuity;  patients with disorientation in time and space	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-8v9x7f9	Effects of delicate containment of the limbs in flexion near the thorax and the winding of the baby with cueiro for the reduction of pain in the premature newborn: cross-clinical trial	Recruiting	Intervention	2021-05-27	<NULL>	<NULL>	4692	Effects of facilitated containment and winding in pain reduction in premature newborn: cross-clinical trial: cross-clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-03-24	Universidade Federal de Alfenas	Hospital de Clínicas de Itajubá	https://ensaiosclinicos.gov.br/rg/RBR-8v9x7f9	<NULL>	Preterm infants of both sexes; gestational age between 32 to 36 weeks and six days; Hospitalization time longer than 24 hours; Weight greater than 1000g; Spontaneous ventilation or noninvasive ventilatory support; Medical prescription for arterial blood collection; Suspension of analgesic or sedative medication in the 12 hours prior to collection; Stability of vital signs considering the characteristics of the newborn.	Neonates diagnosed with heart disease; Genetic alterations and congenital anomalies; Immediate or mediated postoperative; Invasive and non-invasive ventilatory support of the Hood type.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-3fs8ph	Effects of dental bleaching on the satisfaction of patients of different ages	Recruitment completed	Intervention	2018-04-09	<NULL>	<NULL>	1697	Effect of patients’ age on changes of tooth color and esthetic self-perception caused by combined dental bleaching	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-10	Universidade Federal de Uberlândia	FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3fs8ph	<NULL>	It will include patients over 18 years of age up to 25 years and patients aged 40 to 65 years, already selected by the first stage of the research that was dental office bleaching; patients who have never undergone bleaching; non-smoker patients.	Patients who did not complete the first stage of the dental office whitening research will be excluded; patients who refuse to continue bleaching at home; patients who are already satisfied with the color of the teeth post office bleaching.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-7bshzcg	Effects of Dermocosmetics and Ultrasound for Lasertherapy	Recruiting	Intervention	2023-07-13	<NULL>	<NULL>	6236	Effects of Optical Clearing Agent, Ultrasound Therapy and Sonophoresis for Photobiomodulation: randomized clinical trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7bshzcg	<NULL>	White, brown and black men and women. Body mass index (BMI) between 18.5 and 29.9 kg/m2. Skin fold in the vastus medialis area measuring up to 25 mm	Hypersensitivity to OCA-IPQ, such as redness and itching; skin lesions in the vastus medialis region such as open wounds; tattoos; history of skin cancer; cognitive difficulty reporting thermal sensation; pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-6r9jw7c	Effects of detraining and retraining on the health of the elderly	Data analysis completed	Intervention	2024-10-08	<NULL>	<NULL>	7411	Physical Exercise for promoting the health of older women	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6r9jw7c	<NULL>	Be over 60 years old; woman; active; participate in the university extension project	Be under 60 years old; sedentary; not participate in the university extension project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-23mbf7	Effects of detraining on the quality of life of elderly people practicing resistance training in water compared to traditional water aerobics training	Data analysis completed	Intervention	2020-04-13	<NULL>	<NULL>	3741	Effects of detraining on the quality of life of elderly people practicing resistance training in water	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23mbf7	<NULL>	"ge equal or superior to 60 years;
Do not present psychiatric and / or neurological disorder (apparent or diagnosed);
Be able to practice physical activity, proven by a medical certificate brought by the patient; have participated in the hydro gymnastics program in the last six months."	the elderly who were unable to visually recognize digits; were affected by any disabling illness that did not allow them to be physically active; having been injured during the program; have been absent from the Hydrogynas program for more than 5 consecutive days; and been participating in any other regular physical activity program in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-8whr7r	Effects of diagnostic errors on variability of assessment and intervention with acupuncture	Recruitment completed	Observational	2015-06-01	<NULL>	<NULL>	492	Effects of diagnostic errors on Interrater Reliability for Pattern differentiation and Acupoints prescription	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-11-27	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-8whr7r	<NULL>	Adults; either gender; bachelor degree in any health-related course recognized by the National Ministry of Education, including biomedicine, nursing, physical therapy, speech therapy, physician, nutrition, dentistry, psychology, and occupational therapy; postgraduate training in acupuncture; signature of the informed consent form after reading about the objectives, potential risks and benefits for participating in this research.	Professionals with postgraduate training not registered at the respective professional council; clinical practice less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4cpbr5	Effects of diamond peeling on spots in the female inguinal region	Data analysis completed	Intervention	2018-05-16	<NULL>	<NULL>	1804	Effects of diamond peeling on hyperchromic spots and folliculitis in the female inguinal region	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-09	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4cpbr5	<NULL>	Women older than 18 years; presence of hyperchromic spots in the inguinal region; literate; able to respond to research questionnaires	"Women who were in dermatologicalfunctional treatment to improve the hyperchromic spots of the inguinal region; predisposition to keloids; tissue lesions and infectious skin disease; presence of hormonal, cardiac, respiratory diseases, diabetes mellitus, systemic arterial hypertension and neoplasms;
inability to provide sensitive feedback or with changes in cutaneous sensitivity; not to attend three consecutive days of treatment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-2rcph2	Effects of diet on the intestinal health of patients with liver fat	Recruitment completed	Intervention	2018-08-15	<NULL>	<NULL>	2121	Effects of Nutritional Intervention on the nutritional profile, inflammation and intestinal health of outpatients with Hepatic Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-02	Faculdade de Medicina de Universidade Federal de Juiz de Fora	Faculdade de Medicina de Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2rcph2	<NULL>	Age greater than 18 years; both genders;  previous diagnosis of non-alcoholic steatohepatitis by means of liver biopsy.	Presence of chronic hepatitis B; chronic hepatitis C; autoimmune diseases of the liver; hemochromatosis; HIV-1 and 2-infected patients; patients with drug-induced; alcohol-induced liver disease (greater than 30 g / day in men or greater than 20 g / day in women); use of antibiotics in the two months prior to inclusion in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-848sdg	Effects of Diet to Combat Hypertension, Improve Obesity and Intestinal Bacteria in High Blood Pressure Patients	Recruitment completed	Observational	2019-11-18	<NULL>	<NULL>	3194	"Effects of the intervention of the method to combat hypertension through diet
(DASH) on cardiovascular risk factors, endothelial function and intestinal microbiota
in patients with cardiovascular disease"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-08	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-848sdg	<NULL>	Elderly female and male patients with body mass index (BMI) above 18.5 Kg / m² for both sexes, older than 60 years up to 85 and diagnosed with systemic arterial hypertension according to the study will be included in the study. the Brazilian Society of Cardiology criteria. The fit patients who were invited to participate in the research by reading and signing the Informed Consent Form (ICF). Patients will be followed for 6 months in monthly outpatient consultations, R24h were performed in all consultations in both groups. For GI patients, recipes adapted to the DASH diet model will be performed. Laboratory tests, body composition analysis and food frequency questionnaire will be performed at the beginning and end of the research. Patients will be followed up via phone contact, email or text messages weekly.	The study considered patients ineligible for prebiotics, probiotics, symbiotics supplementation in the last 3 months or receiving antibiotic therapy. Patients with glomerular filtration rate &lt;60 ml / min, presence of pacemaker, presence of infectious or autoimmune disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-8ttw64	Effects of dietary guidance in children attending outpatient preventive cardiology: randomized clinical trial	Recruiting	Intervention	2013-12-09	<NULL>	<NULL>	272	Effects of dietary guidance in children attending outpatient preventive cardiology: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Instituto de Cardiologia Fundação Universitária de Cardiologia- IC/FUC	Número do Parecer: 400.879 - Comitê de Ética em Pesquisa do Instituto de Cardiologia do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8ttw64	<NULL>	Children both genders aged 7-11 years whose parents or caregivers signed an informed consent form, reside in the state of Rio Grande do Sul and having overweight overweight or obese according to the criteria of the World Health Organization.	Children with neurological disorders that interfere with learning, cognitive deficits eg Disorder Attention Deficit Hyperactivity Disorder; contraindications for physical activity group and using drugs that interfere with the body weight or lipid profile, such as statins, ritonavir, furosemide hidrocloritiazida, propranolol, nadolol, prednisolone among others.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-3shhxs	"Effects of dietary intervention on toxicity and quality of life in patients with
Breast Cancer during chemotherapy treatment Neoadjuvant: randomized clinical trial"	Recruitment completed	Intervention	2018-11-12	<NULL>	<NULL>	4222	"Effects of dietary intervention on toxicity and quality of life in patients with
Breast Cancer during chemotherapy treatment Neoadjuvant: randomized clinical trial"	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Federal do Rio Grande do Norte - UFRN	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3shhxs	<NULL>	Adult volunteers; age between 20 and 59 years; with diagnosis of breast cancer; with clinical and cognitive conditions to participate in the study stages; have not started any specific type of oncological treatment; have indication for neoadjuvant chemotherapy treatment; nutritional risk; not being in nutritional outpatient follow-up and have recent computed tomography of total abdomen.	Volunteers who are already undergoing some kind of cancer treatment; with AIDS diagnosis; non-cancerous liver diseases; tuberculosis; neurological disorders; at nutritional risk and with computed tomography prior to 60 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-2mtwjnz	Effects of Dietary Polyphenol Intake and Physical Activity on Body Fat, Metabolic and Inflammatory Markers in Breast Cancer Survivors – PROjeto POlifenóis no CAncer de Mama (PROPOCAM)	Recruiting	Intervention	2025-09-25	<NULL>	<NULL>	8313	Effects of Dietary Polyphenol Intake and Physical Activity on Body Fat, Metabolic and Inflammatory Markers in Breast Cancer Survivors: a Randomized Clinical Trial – PROjeto POlifenóis no CAncer de Mama (PROPOCAM)	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-20	Universidade Federal de Santa Catarina - UFSC	Prefeitura Municipal de Imbituba	https://ensaiosclinicos.gov.br/rg/RBR-2mtwjnz	<NULL>	Sample inclusion will follow the criteria below: women with a diagnosis of primary breast cancer confirmed by histopathological evidence of malignancy; staging classified as 0 to IIIb at the time of diagnosis; completion of chemo- and/or radiotherapy treatment at least 6 months prior to the start of the study and less than 5 years; age between 30 and 75 years; sedentary women (&lt;60 minutes of physical activity per week); BMI &gt;25 kg/m²; medical clearance to engage in physical activity issued by an oncologist or cardiologist; no regular alcohol consumption (no more than one drink/week — i.e., one can of beer, 150 mL of wine, or 45 mL of distilled beverage); no use of dietary supplements within the previous 3 months and no current clinical conditions such as infections or visible/known inflammatory processes; absence of cardiovascular, endocrine, gastrointestinal, renal, or hepatic diseases.	The non-inclusion criteria will comprise the following factors: history of other types of cancer; presence of metastasis or recurrence; pregnancy or lactation; BMI &lt;25 kg/m²; current smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-3q9vgk9	Effects of dietary restriction of ultra-processed foods on the health of individuals with excess weight	Data analysis completed	Intervention	2023-04-18	<NULL>	<NULL>	8012	Effectiveness and metabolic impacts of restricting the consumption of ultra-processed foods on metabolic adaptation and weight regain in individuals with excess weight submitted to caloric restriction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Univerisidade Federal de Alagoas	Univerisidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-3q9vgk9	<NULL>	Adult individuals (19-60 years old); with the wish to lose weight; with a stable weight for at least 1 month; with obesity defined by two of the following three criteria: body mass index between 25 and 40 kg/m2, waist circumference bigger or equal to 88 cm for women and bigger or equal to  102 cm for men, body fat percentage of 35% for women and 25% for men determined by bioelectrical impedance	Individuals using chronic medications (anti-diabetics, anti-retrovirals, immunosuppressants, anti-depressants) or on hormone replacement; those with a condition that makes it impossible to carry out anthropometry or measure the components of energy expenditure; menopause, pregnant or lactating women; those who have already undergone any surgical intervention for weight loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-55mwvb	Effects of different Cementitious materials on the longevity of Ceramic crowns - A clinical research	Recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2744	Effects of different Cementation strategies on clinical performance of Zirconia crowns-A randomized clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2013-11-28	Voco do Brasil Ltda	Voco do Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-55mwvb	<NULL>	Patients must be at least 18 years of age; good general health; at least 20 teeth present in the mouth; healthy gum tissue and use of two zirconia crowns in the anterior or posterior region; Where the maximum horizontal mobility is 1mm be accepted.	Patients who suffer from bruxism, poor oral hygiene and periodontal disease will be deleted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-98qjbw	Effects of different cognitive behavioral therapies to social anxiety disorder using different measures	Recruitment completed	Intervention	2016-09-08	<NULL>	<NULL>	989	Effects of different cognitive behavioral therapies to social anxiety on memory, attention and galvanic skin response	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto - Universidade de São Paulo	Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-98qjbw	<NULL>	There are different inclusion criterias for participants with social anxiety disorder and healthy individuals. Inclusion criteria for participants with social anxiety disorder: individuals aging 18 to 45 years old; both gender; with scores equal or higher than 19 points at social phobia inventory; and confirmation of social anxiety disorder as the primary diagnoses. Inclusion criterias for healthy individuals: healthy volunteers aging 18 to 45 years old; both gender; that do not present social anxiety disorder ou any other mental disorder.	Age under 18 and older than 45 years old; psychotic symptoms and accentuated cognitive deficits; and the presence of social anxiety disorder as a secondary diagnoses to other disorders and conditions; individuals in  psychotherapy treatment until the beggining of the interventions and that did not want to interrupt the treatment in progress. Exclusion criterias to comparison healthy group: any psychiatric condition, beside all the exclusion criterias described above.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-9t7r5p	Effects of Different Fluids Administered During the Renal Transplantation from Deceased Donor in the Renal Function after the Transplant	Recruitment completed	Intervention	2017-06-12	<NULL>	<NULL>	4583	Effects of Plasma-Lyte or Normal Saline on Renal Function After Renal Transplantation from a Deceased Donor. A Randomized Controlled Trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9t7r5p	<NULL>	Patients with chronic renal disease under hemodialysis, aged 18 to 65 years, both genders, physical status III and IV according to the American Society of Anesthesiologist (ASA)	Patients with preoperative hemoglobin less than 8 g/dL and those under peritoneal dialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-7x9gby	Effects of different intensities of Aerobic Training in women with Headache	Recruiting	Intervention	2017-12-11	<NULL>	<NULL>	1516	Effects of different intensities of Aerobic Training in women with Migraine or Tension-type Headache: Randomized and Controlled Clinical Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-28	Associação Cauaruense de Ensino Superior	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7x9gby	<NULL>	"Age between 20 and 30 years; 
Nulliparous and nulliparous; For the group with headache: women with clinical diagnosis of migraine or episodic tension-type headache, performed by a neurologist, through anamnesis and neurological examination, based on the diagnostic criteria of the
ICDH; Body Mass Index (BMI) &lt;30kg / m² (WORLD HEALTH ORGANIZATION, 2011); Will be included in the migraine group, women diagnosed with migraine with aura, without aura or both, probable migraine or migraine associated with tension-type headache; 
Women who do not present with severe heart disease, neurological diseases, disabling musculoskeletal diseases, cognitive problems or those with clinical conditions of instability that imply risk and / or inability to participate in the training program;"	"Chronic migraine or chronic tension-type headache; 
Women with low adherence to training (frequency less than 75% of sessions in a one-month period) will be excluded; 
pregnancy; Drug or alcohol abuse; 
Use of antipsychotic or antidepressant medications;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-4n525b2	Effects of different intensities of physical exercise on mood and biochemical markers of individuals with depressive disorder	Recruiting	Intervention	2023-07-14	<NULL>	<NULL>	6241	Effects of different intensities of physical exercise on the quinurenine pathway, mood states and affect in individuals with depressive disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-19	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4n525b2	<NULL>	Both genders. Age between 20 and 45 years. With a minimum schooling time of 8 years. affected or not by depressive disorder, the latter with a diagnosis of at least 3 months. Considered minimally active. Considered in good health after medical evaluation. They must not have undergone surgery in the last 6 months. Must not have any physical, muscle and/or joint problems	Those who, for whatever reason, do not complete the tests within the stipulated period will be excluded from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-74pcmw	Effects of different intensities of Resistance Training, Walking and Stretching in patients with Fibromyalgia Syndrome	Recruiting	Intervention	2017-09-21	<NULL>	<NULL>	3552	Effects of different intensities of Resistance Training, Walking and Stretching in patients with Fibromyalgia Syndrome: randomized controlled trials	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-10	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-74pcmw	<NULL>	"Clinical diagnosis of fibromyalgia; Women;
Over 18 years old; Medical certificate for physical exercise"	Present some incapacitating disease for physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-6wryhb9	Effects of different methods to treat myofascial pain	Not yet recruiting	Intervention	2021-10-11	<NULL>	<NULL>	4966	Effects of different methods to treat myofascial trigger points: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-04	Universidade Estadual Paulista, Instituto de Biociências	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6wryhb9	<NULL>	Both genders; between 18 to 40 years old; presence of trigger points in the musculature; physically active; signed the statement of informed consent	Body Mass Index (BMI) above 30; have used analgesic, anti-inflammatory, anticoagulant, muscle relaxant or antipyretic medications up to 24 hours before; needle phobia; pregnant women; performed strenuous exercises or used stimulants 24 hours before; sensitivity or mental disorders diagnosed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-9gh46r	Effects of different modalities and different intensities of physical rehabilitation on the Elimination of protein in the urine in patients with chronic kidney disease not requiring dialysis hypertensive origin	Not yet recruiting	Intervention	2016-01-12	<NULL>	<NULL>	680	Action of different modalities and intensities of physical rehabilitation on albuminuria of patients with non-dialysis dependent hypertensive nephrosclerosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-10	Faculdade de Medicina de Botucatu	Prefeitura Municipal de Itaí	https://ensaiosclinicos.gov.br/rg/RBR-9gh46r	<NULL>	Minimum age of 18 years; patients with chronic kidney disease in hypertensive origin; with elimination of the protein albumin in the urine with more than 30 milligrams per gram of creatinine, family history of hypertension, hypertension preceding the elimination of prteína; the presence of ventricular hypertrophy on electrocardiogram signals.	Patients who are on dialysis; Albuminuria greater than or equal to 2,000 milligrams per gram of creatinine; History or evidence of angina or myocardial infarction; Treadmill exercise test positive for coronary heart disease; Cardiac arrhythmias; Musculoskeletal restrictions that preclude participation; Hemodynamic instability; Diabetic patients; Exposure to nephrotoxins; Evidence glomerular diseases; Presence of systemic diseases that can affect the kidneys.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-7z358j	Effects of different oils consumption associated with diet on weight loss	Not yet recruiting	Intervention	2015-05-13	<NULL>	<NULL>	471	Effect of different fat sources consumption associated with low-calorie diet in controlling excess body weight	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal de Viçosa - UFV	Faculdade de Ciências Aplicadas da UNICAMP - Limeira	https://ensaiosclinicos.gov.br/rg/RBR-7z358j	<NULL>	women; with 20 to 40 years old; overweight and with high body fat; basal energy requirements between 1200 to 1500kcal/day	presence of chronic diseases; weight and physical activity instability; use medication that affects some parameter assessed in the survey; smokers; pregnant or lactating; presence of eating disorders; presence of intestinal disorders; alcoholic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-6bqsw8	Effects of different physical activities programs on osteoporosis related-variables in older women	Recruitment completed	Intervention	2015-07-21	<NULL>	<NULL>	552	Low bone mineral density related-variables in postmenopausal women, practitioners of different physical activities programs	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-08	Universidade Federal do Estado do Rio de Janeiro (UNIRIO)	Universidade do Estado do Pará (UEPA)	https://ensaiosclinicos.gov.br/rg/RBR-6bqsw8	<NULL>	Female volunteers; aged over or equal 50 years; with low BMD (T – score &lt; -1DP); different ethnic population (descendants of Europeans, Blacks and Indians); patients being treated with sodium alendronate (70 mg) and/or vitamin D3; postmenopausal women (menopause of age self-declared); no previous history of fractures; no regular practice of physical activity for at least 1 year; with indication / medical clearance for physical exercises practices.	Who made some kind of surgical procedure in the last six months; who had early menopause by ovary removal; with uncontrolled hyperteho made some sort of surgery in the last snsion; that use additional bone active medications or hormone replacement therapy and volunteers who were being treated with drugs that induces low BMD, as glucocorticoids; volunteers with excessive use for alcohol and tobacco; that were not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-76c257	Effects of different physical activity programs on women&apos;s health	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3906	Effects of Long-Term Physical Activity Programs on Physical Capacity, Body Composition and Symptoms of Anxiety and Depression in Women	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-76c257	<NULL>	Being female; age between 18 years and 80 years; body mass index (BMI) greater than or equal to 25 kg / M2; use the public health service.	against medical indications to perform physical activity with moderate and vigorous intensity; have a cardiac pacemaker; pregnant women; already carry out physical activity programs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-2t7pt25	Effects of different Physical Exercise interventions performed at home on physical conditioning, physical activity level and aspects related to the quality of life of the elderly	Data analysis completed	Intervention	2023-02-13	<NULL>	<NULL>	5901	Effects of different Physical Exercise interventions performed remotely on physical fitness, physical activity level and aspects related to the quality of life of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-26	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2t7pt25	<NULL>	Participants must be men and women between the ages of 60 and 70; not practicing physical exercises regularly and systematically for at least twelve months; be a resident of the State of Rio Grande do Sul; have internet access and device for video calling	Smokers; uncontrolled cardiovascular disease; no internet access; any musculoskeletal problems that prevent physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-9mmhnw	Effects of different Post-Effort Methods on Muscle Strength and Heart Rate Variability in diverse Sports Practitioners	Recruiting	Intervention	2017-07-10	<NULL>	<NULL>	1285	Influence of different therapeutic interventions of Post-Exercise Recovery on Muscle Performance and Cardiac Autonomic Modulation in practitioners of different Sports Modalities	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9mmhnw	<NULL>	Adult volunteers; practitioners of judo, handball, basketball, volleyball or indoor soccer.	Volunteers having presented sport practice history lower than one year; presence of sport injuries; physical treatment with medicines having affected the cardiac autonomic activity; presence of inflammatory processes, infections, metabolic or cardiorespiratory diseases; presence of Raynaud Syndrome or cold allergy; practice of exercise within last 24 hours previous to the investigation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-5z98vxb	Effects of different rehabilitation protocols in adults and elderly individuals with chronic post-Chikungunya joint pain	Not yet recruiting	Intervention	2025-03-11	<NULL>	<NULL>	7831	Efficacy of different rehabilitation protocols on biopsychosocial variables in adults and elderly people with chronic post-Chikungunya arthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5z98vxb	<NULL>	Individuals infected with the Chikungunya virus with chronic arthralgic symptoms (more than 3 months); pain level more than 0 on Visual Analogical Scale; of both sexes; aged over 18 years old	Individuals who present any contraindication to the proposed interventions; who do not respond to simple commands; who present arthralgic symptoms of origin other than Chikungunya virus infection; who are carrying out other physical treatment protocols or begin during the intervention; who use wheelchair-type walking aids or bedridden individuals who have some severe comorbidity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-7p32sbb	Effects of different tonic, isometric, and isometric and vibratory Strength Training programs on Motor Symptomatology in People with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6700	Effects of different tonic, isometric, and isometric and vibratory Strength Training programs on Motor Symptomatology in People with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-15	Universidad de las Americas	Universidad de Atacama	https://ensaiosclinicos.gov.br/rg/RBR-7p32sbb	<NULL>	Individuals of both sexes; diagnosis of Parkinson&apos;s disease in stages I-III according to the Hoehn and Yahr classification; authorized by your treating physician to participate in the intervention program; controlled medication; able to follow verbal instructions and with motor autonomy; mini - mental exam score greater than 23 points; Signed informed consent to participate in the study	Participants with adherence below 80% to the different types of intervention sessions will not be included in the results analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-102mkz52	Effects of different training volumes in the elderly on muscular and cardiovascular function	Recruitment completed	Intervention	2022-06-28	<NULL>	<NULL>	5449	Different training volumes in the elderly: effects on muscle function and cardiovascular	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-14	Universidade Federal do Estado de São Paulo	Universidade Federal do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-102mkz52	<NULL>	Men and Women aged over 60 years; no psychiatric or neurological disorder; be able to practice physical activity, proven by a medical certificate; that present physical conditions that allow the execution of the tests; sedentary for at least 6 months	have any disease that does not allow the practice of regular physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5m4dt7	Effects of Different Trainings to Strengthening Pelvic Floor Muscles	Recruitment completed	Intervention	2013-08-07	<NULL>	<NULL>	221	Effects of Different Training Protocolos in Function and Electrical Activity of the Pelvic Floor Muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-03	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5m4dt7	<NULL>	Age between 18-30 years. Active sex life, defined as reporting any sexual intercourse in the last three months. Active and non-athletes, physical activity for more than 150 minutes per week. Normal body mass index (BMI) (between 18.5 and 24.9 kg/m2.	Current pregnancy or prior. Reporting of urinary leakage last week. Presence of pelvic organ prolapse. Presence of constipation, defined as weekly evacuation less than three times. Presence of pelvic pain. History of pelvic surgery. Amenorrhea.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-3c7rt3	Effects of different types of Aerobic Exercise and Weight Training protocols combined on adult health indicators with Obesity	Not yet recruiting	Intervention	2018-02-07	<NULL>	<NULL>	3198	Effects of different Concurrent Exercise Training protocols in health indicators of Obese adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-26	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3c7rt3	<NULL>	"To be voluntary;
Have BMI greater than or equal to 30kg / m²;
Having a minimum and maximum age of 20 and 50,
respectively;
To present medical certificate releasing him to practice physical exercises;
To present an electrocardiogram performed in the last year;
Not being engaged in physical exercise programs since the last 3 months;
Do not be a smoker;
Do not drink alcohol in excess (5 doses at a time)."	"Have the BMI greater than 39.9kg / m2;
Have a diagnostic of some other chronic disease;
Have any physical, visual, auditory, motor or cognitive deficiency;
Use of any medication for the control and / or treatment of obesity;
Have performed some surgical procedure aiming the weight reduction."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-63s483	Effects of different types of hydration on the cardiovascular system	Recruitment completed	Intervention	2014-04-07	<NULL>	<NULL>	283	Hydration in endurance exercise: effects of different protocols on the variability of heart rate, cardiorespiratory parameters, heart rate recovery and reentry vagal	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-08	Universidade Federal de São Paulo (UNIFESP)	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-63s483	<NULL>	Healthy volunteers, male, aged between 18 and 30 years; practicing moderate physical activities according to the International Physical Activity Questionnaire - IPAQ	Smokers volunteers, use of medications that affect the autonomic activity of the heart such as beta-blockers and angiotensin-converting enzyme inhibitors; alcoholics; diagnosis of metabolic and/or endocrine known as a diabetes mellitus and dislipedemia example, that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-2hjj7g	Effects of different types of physical exercise programs on the physical and mental health of the elderly	Data analysis completed	Intervention	2020-10-27	<NULL>	<NULL>	4349	Effects of different types of physical exercise programs on physiological, functional, cognitive and emotional variables in elderly individuals	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual de Londrina	Ministério da Educação	https://ensaiosclinicos.gov.br/rg/RBR-2hjj7g	<NULL>	Elderly aged 60 or over; physically independent; normal mental state; non-participants in guided physical exercise programs in the last three months at the beginning of the study.	Orthopedic problems; diseases that make physical training impossible to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-9tgfkmy	Effects of dog therapy and aromatherapy on institutionalized elderly people	Other	Intervention	2025-11-06	<NULL>	<NULL>	8493	Effects of integrative therapies on institutionalized elderly people: use of essential oils and dog-assisted therapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Departamento de Saúde Coletiva da Universidade Federação do Rio Grande Norte	<NULL>	<NULL>	<NULL>	Institutionalized elderly individuals aged ≥ 60 years; both sexes; score ≤ 25 on the Mini Mental State Examination (MMSE); signed informed consent	Elderly people afraid of dogs; allergy to dogs; dog phobia; non-residents in Long-Term Care Institutions for the Elderly	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-8kqgnst	Effects of Dry Needle on Points of Muscle Tension in Subjects with Chronic Ankle Instability	Recruiting	Intervention	2021-11-19	<NULL>	<NULL>	5052	Effects of Dry Needling on Myofascial Trigger Points on the Sensory-Motor System of Subjects with Chronic Ankle Instability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-19	Universidade Federal da Paraíba	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8kqgnst	<NULL>	be between 18 and 35 years old; present a history of a unilateral ankle sprain for at least 12 months;  report at least 2 episodes of instability sensation in the same ankle in the last 6 months; not having joint movement blockage due to surgical fixation, ankylosis or ankle arthrofibrosis;  not having undergone surgery in the lower limbs in the last 6 months;  not being in physiotherapeutic treatment for ICT; having a sensation of instability in the ankle (&lt; 25 points in CAIT); not having systemic disease, vascular disease in the lower limbs and pain syndromes; no symptoms of peripheral nerve damage;  do not use non-steroidal anti-inflammatory drugs or any medication that alters the perception of pain.	not completing the proposed intervention; absence in at least one of the evaluations;  present pain or worsening of the clinical condition with the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-4mg56yt	Effects of Dry Needling on lungs&apos; air flow, balance and gait of individuals with Parkinson&apos;s Disease	Suspended	Intervention	2023-03-01	<NULL>	<NULL>	5926	Effects of Dry Needling on ventilatory mechanics, balance and gait of individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-04	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mg56yt	<NULL>	Parkinson&apos;s Disease sufferers; both sexes; over 50 years of age; stages 1 to 3 on the Hoehn-Yahr Scale; able to ambulate and remain standing; being monitored by a neurologist; taking levodopa	Use of walking aids; freezing; previous lung involvement; smokers; history of thoracic surgery; with a diagnosis of associated dementia syndrome; needle phobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-89mvgbm	Effects of dual task training and tDCS in children with spastic cerebral palsy	Data analysis completed	Intervention	2022-04-01	<NULL>	<NULL>	5324	Motor-cognitive dual task associated with anodic Transcranial Direct Current Stimulation in children with Spastic Cerebral Palsy: controlled, randomized and double bling clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de São Paulo	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-89mvgbm	<NULL>	Diagnosis of spastic cerebral palsy; functional classification on Levels I, II or III of the Gross Motor Function Classification System (GMFCS); ability to walk independently in at least the previous 12 months, even if requiring a gait-assistance device; age between six and 12 years (age corresponding to the period of concrete operations and logical thinking); degree of understanding and cooperation compatible with the execution of the proposed activities; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant.	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-10sq7mnk	Effects of dual-task training on gait in elderly people	Recruiting	Intervention	2025-07-17	<NULL>	<NULL>	8135	Effects of dual-task training on the gait of physically active and institutionalized elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade de Caxias do Sul	Universidade de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-10sq7mnk	<NULL>	Elderly people over the age of 60, who are clinically stable and without acute health conditions that could compromise participation in the training, will be included in the study. Literate individuals, with sufficient cognitive capacity to understand the instructions given. Elderly people who maintain the ability to walk independently, without motor restrictions that prevent participation in training. Everyone who agrees to participate voluntarily and who signs the Free and Informed Consent Form	Individuals who present a cognitive deficit or insufficient level of understanding to perform the tests, who present functional limitations to walking (disabling pain and/or sequelae of neurological or orthopedic diseases) will be excluded. Individuals with motor restrictions and the presence of diseases that make it impossible for participants to complete the protocol. Elderly people who are not able to walk independently and who use assistive devices for mobility. Furthermore, participants involved in other similar training programs during the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-9c72hyz	Effects of Duloxetine on muscle loss associated with knee arthrosis	Recruitment completed	Intervention	2021-01-04	<NULL>	<NULL>	4455	Effects of Duloxetine on Sarcopenia associated with knee Osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-16	Sociedade Brasileira de Reumatologia	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9c72hyz	<NULL>	Osteoarthritis; Pain&gt;7 (visual analog scale); Low/moderate physical performance	Contra-indications to study&apos;s interventions; Inability to walk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-9h77k7	Effects of Ear Acupuncture and Cupping Therapy with glasses on Back Pain	Not yet recruiting	Intervention	2017-10-16	<NULL>	<NULL>	1420	Effects of Auricular Acupuncture and Cupping Therapy on Chronic Back Pain: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9h77k7	<NULL>	Age (between 18 and 80 years); orientation in time, space and person; presence of chronic pain in the vertebral column for three months or more, of any origin; self-report of pain intensity bigger or equal 4, and availability of time for submission to treatment sessions.	Infection, inflammation or injury in the ear; use of piercing (except normal earring); allergy to metal or micropore; decreased skin turgor, skin lesions or diseases in the dorsal region; treatments with anticoagulant; use of other energy therapies (massage, herbal medicine, reiki, floral therapy) up to three months prior to the study; physiotherapy treatment concomitant with the proposed interventions; continuous use of medication for pain relief; neurological, psychiatric or rheumatic disease; pregnancy; breastfeeding; and not respond to three attempts of contact made by the researcher.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-8cxnvr2	Effects of ear acupuncture on mental health of university students in the Covid-19 pandemic: clinical study	Recruiting	Intervention	2023-04-12	<NULL>	<NULL>	5997	Effects of Laser and Needle Auricular Acupuncture in treatment of Emotional Disorders in university students in the post-Covid-19 pandemic context: randomized clinical	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-20	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-8cxnvr2	<NULL>	University students; aged 18 years or older; who have moderate or high levels of anxiety, stress and/or depression on the Depression, Anxiety and Stress Scale (DASS21) and/or post-traumatic stress disorder, assessed on the Revised Event Impact ( IES-R)	Perforations in the ear near the applied ear points; history of allergy to metal or microporous tape; history of photosensitivity; ear injury, inflammation, deformity or tattoo; history of skin cancer in the head and neck region; use of chemical peeling (retinoic acid, retinol, vitanol-A, tretinoin, isotretioin) and/or Rocutan (isotretinoin) up to six months prior to the start of treatment; use of hearing aids; people with compromised immune systems (being treated for cancer or using immunosuppressants, for example); diabetes mellitus (type 1 or type 2); epilepsy; use of cardiac pacemaker; pregnant women, nursing mothers or those women who are planning pregnancy during the study period; rejection or fear of receiving the intervention; refusal to carry out the assessments; have carried out some integrative and complementary practice in the last 3 months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-102g7f3m	Effects of ear Acupuncture on the Mental Health of college students: a clinical study	Not yet recruiting	Intervention	2025-07-09	<NULL>	<NULL>	8109	Auricular Acupuncture in the treatment of Emotional Disorders in university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-102g7f3m	<NULL>	Postgraduate strictu sensu students who present moderate or high levels of anxiety, stress, and/or depression according to the Depression, Anxiety, and Stress Scale (DASS-21); who agree to be randomly allocated to the study groups; of both genders; and who are 18 years of age or older	Ear piercings (except in the earlobe); history of allergy to metal or microporous tape; history of photosensitivity; injury, inflammation, deformity, or tattoos on the ear; history of skin cancer in the head and neck region; use of hearing aid; use of chemical peels (such as retinoic acid, retinol, Vitanol-A, tretinoin, isotretinoin) and/or Roaccutan® (Isotretinoin) up to six months prior to the start of treatment; individuals with compromised immune systems (e.g., undergoing cancer treatment or using immunosuppressive medications); epilepsy; use of a cardiac pacemaker; pregnant or breastfeeding women, or those planning to become pregnant during the study period; rejection of or fear of receiving the technique; and undergoing any other form of energy therapy concurrently with the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-28xttdt	Effects of ear Acupuncture on the mental health of nursing professionals	Not yet recruiting	Intervention	2023-08-15	<NULL>	<NULL>	6353	Effects of Chinese Auricular Acupuncture on Compassion Fatigue and emotional health of nursing professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Hospital Universitário Júlio Muller	Hospital Universitário Júlio Muller	https://ensaiosclinicos.gov.br/rg/RBR-28xttdt	<NULL>	nursing professionals with at least 6 months of practical experience; who work in sectors that provide direct care to patients; that you have answered all the questions in the questionnaires; who have available time to participate in the stages of the research, and who agree to participate in the research by signing the Free and Informed Consent Term	having a previously diagnosed severe psychiatric disorder in continuous use of psychotropic medications; being pregnant, on vacation, or on leave during the intervention period; act only in administrative functions; presenting skin lesions, infection, inflammation or injury to the ear; allergic to adhesive tape in the pavilion; excessive oiliness in the ear; use a hearing aid; use steroidal anti-inflammatory drugs or opioid analgesics; to have  coagulation disorders, or to use anticoagulants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-99xqr4t	Effects of ear Acupuncture on the Mental Health of nursing professionals in a cancer hospital	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7631	Effects of Chinese Auricular Acupuncture on Compassion Fatigue and Emotional Health of nursing professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-16	Hospital Universitário Júlio Müller	Secretaria do Estado de Saúde de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-99xqr4t	<NULL>	nursing professionals; of both sexes; aged 18 or over; with at least 6 months of practical experience; who work in sectors that provide direct patient care; who have answered all the questions in the questionnaires; who have time available to participate in the research stages; and who agree to participate in the research by signing the free and informed consent form	having a previously diagnosed severe psychiatric disorder and currently using psychotropic medications at the time of data collection; being pregnant; working exclusively in administrative functions (unit management and nursing coordination); using a hearing aid; presenting dermatological lesions; infection; inflammation; or injury in the auricular pavilion; or being allergic to adhesive tape on the auricle; or excessive oiliness in the ear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-453vyf	Effects of early aerobic exercise after cardiac surgery	Recruiting	Intervention	2015-07-27	<NULL>	<NULL>	562	Effects of early aerobic exercise after coronary artery bypassa grafting: a randomized controlled clinical trial during hospitalization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-453vyf	<NULL>	Patients undergoing elective coronary artery bypass surgery in the proposed period.	Use of intra-aortic balloon or other invasive device inserted by femoral artery;Surgical reintervention immediate postoperative period; Perioperative death; Prolonged Hospitalization above 10 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-529dpg	Effects of early mobilization on normal and cesarean birth	Data analysis completed	Intervention	2019-08-07	<NULL>	<NULL>	2865	Physiotherapy assistance in the immediate puerperium: a comparative study between normal birth and cesarean	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-529dpg	<NULL>	The study included women with 8 hours normal postpartum and 14 hours postpartum cesarean section, primiparous and multiparous, with medical authorization to perform physiotherapy, without any complications, such as hemorrhages and who accepted to be part of the study after the signature of the free and informed consent term	Were excluded from the study postpartum women less than 8 hours normal postpartum and 14 hours post-partum cesarean section, complications during delivery and postpartum, with anesthesia headache, bleeding, exacerbated pain in another body part, carriers of morbidities such as diabetes and hypertension who underwent curettage and tinnitus without medical authorization to receive physical therapy and who did not accept to be part of the study after reading the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-7dydc4h	Effects of early treatment of anterior open bite with orthodontic aligners and removable palatal crib	Recruitment completed	Intervention	2024-04-26	<NULL>	<NULL>	6970	Effects of early treatment of anterior open bite with orthodontic aligners and removable palatal crib: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-15	Universidade Anhaguera - UNIDERP	Universidade Anhaguera - UNIDERP	https://ensaiosclinicos.gov.br/rg/RBR-7dydc4h	<NULL>	Age between 7 and 10 years; Angle Class I malocclusion; anterior open bite (AOB) equal to or greater than 1 mm; erupted central incisors and upper and lower permanent first molars; both sexes	Presence of craniofacial deformities; absence of permanent teeth; severe crowding; posterior crossbite or previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-8w2kjkn	Effects of edible mushroom supplementation on Hypertension, heart function and gut: a clinical study	Recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7962	Effects of mushroom (pleurotus ostreatus) supplementation on blood pressure, autonomic function, and gut microbiota in patients with Arterial Hypertension: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Centro de Ciências da Saúde da Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8w2kjkn	<NULL>	Adults aged 20 to 59 years; both sexes; medical diagnosis of high blood pressure; eutrophic nutritional status	People with disabilities that prevent them from taking exams; pregnant women; kidney disease; dyslipidemia; diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-82szgp	Effects of eight weeks of traditional set and intra-set interval training on muscle strength and power	Recruitment completed	Intervention	2019-11-15	<NULL>	<NULL>	3188	Effects of eight weeks of traditional versus cluster set training on muscle strength and power	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-15	Universidade Federal do Rio de Janeiro - UFRJ	Universidade Federal do Rio de Janeiro - UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-82szgp	<NULL>	Be between 18 and 24 years old; be physically active; do not perform strength training at the gym or perform inconsistently for up to 6 months	Present positive PAR-Q; present osteomioarticular injury that interferes with evaluation results or training; make use of disallowed resources to increase training or evaluation performance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-6g85ff9	Effects of Elastic Bandage in the postoperative of breast Cancer Surgeries	Recruitment completed	Intervention	2023-11-16	<NULL>	<NULL>	8414	Effects of Taping&apos;s application in the immediate post-operative after breast Reconstructive Surgery: Randomized Clinical Trial - BREASTAPING I	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6g85ff9	<NULL>	be female; be between 20 and 70 years of age; having been diagnosed with breast cancer; have indication for surgical treatment of oncoplastic or breast reconstructive surgery.	have an allergy to the taping tape; present psychological or cognitive disorders that prevent understanding of the research and assessment instruments; participants who develop infections, hemorrhages, bruises or other complications in the P.O. will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-7xzvpc	Effects of Elastic Bandage on the change of the position of the scapula and humeral retroversion of the shoulder in youth of handball	Recruitment completed	Intervention	2017-09-21	<NULL>	<NULL>	1397	Effects of Kinesio Taping on Scapular Dyskinesia, Umeral Retroversion and Shoulder Symptomatology in Handball Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7xzvpc	<NULL>	Young female handball players; age between 15 and 25 years; with stable vital signs and normal physical conditions.	"Young people with previous history of shoulder joint injury in the last six months;
Previously submitted to surgery on upper limbs or neck;
Presence of generalized ligament laxity;
Presence of an allergic reaction to the bandage or adhesive tape;
Presence of neurological or systemic disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-7n8vq5	Effects of elastic bands and laser treatment on hand strength with restriction of blood flow	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1965	Influence of elastic bandaging and laser on palmar grip strength in a blood flow restriction protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7n8vq5	<NULL>	Individuals of both sexes; age range between 18 and 30 years; Students of the Federal University of Santa Catarina-UFSC; Only those participants who are able to carry out the proposed activities will be selected.	Individuals with any type of injury to the forearm that compromise the integrity of the musculature; Fractures in the wrist and fingers, with pain in the upper limbs for any reason; obese; hypertensive; cardiopathy; cognitive deficit; manual workers, who do physical activities daily and take medication that interferes with the final results of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-4t57rs	Effects of elastic tape on fuctional activities on healthy young subjects	Recruiting	Intervention	2015-01-30	<NULL>	<NULL>	379	Effects of Kinesiotaping on functional performance on healthy young subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4t57rs	<NULL>	Healthy male subjects; aged 18 to 30 years; Physically active; Height between 1.65 m to 1.85 m; absence of pain and symptoms musculoskeletal	Presence of open wounds or scars in the region of application of KT; hypersensitivity and erythema; lower limb injury in the last 6 months prior to the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-46cmrsb	Effects of Elastic Tape on the activity of the masseter muscle, facial pain and jaw movement	Recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5636	Effects of Kinesiology Tape on electrical activity of the masseter muscle, orofacial pain and mandibular mobility	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-06	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-46cmrsb	<NULL>	Age between 18 and 35 years of age; have orofacial pain; sign the Free and Informed Consent Form	History of allergies to the use of bandages; facial malformation; neurological alteration; neurodegenerative disease; skin lesion in the area where the bandage will be applied; using analgesics, muscle relaxants, antidepressants or anti-inflammatory drugs; gluten intolerance; not performing the requested activities; removing the bandage before the stipulated time; not attending any of the evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-96h3k97	Effects of Electric Current on pain after Breast Augmentation surgery: placebo research protocol	Not yet recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6769	Effects of Transcutaneous Electrical Nerve Stimulation on the intensity of acute postoperative pain in Breast Augmentation: a randomized, placebo-controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Centro de Ciências Biológicas e da Saúde -  Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde -  Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-96h3k97	<NULL>	Women; aged between 18 and 65; Requests for breast augmentation surgery using the 24-hour rapid recovery protocol; report a pain intensity significantly equal to or greater than 3 points on the Numerical Pain Scale in the immediate postoperative period	Chronic diseases; previous experience with electrical currents for pain; history of use of illicit and psychotropic drugs; chronic use of opioids; presence of a cardiac pacemaker; neurological disorders that interfere with the level of consciousness; changes in previous skin sensitivity in the breast; inability to support the shoulder elevated at 90 degrees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-2jq26n	Effects of electric current treatment on diabetic foot healing	Not yet recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3206	Effects of therapeutic resources on vascularization and healing of diabetic foot	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2jq26n	<NULL>	Patients of both sexes aged 40 years and over; with type II diabetes mellitus who have vascular and / or neurological complications in the lower limb due to diabetes mellitus.	Patients with diabetes who have lower limb amputation; some psychiatric disorder that may not understand and opt for their participation in the study; active infectious processes; decompensated hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-7gt9pb	Effects of electric stimulation cutaneous and vaginal in women with stress urinary lost	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	49	Comparison of the effects of intravaginal electrical stimulation and surface electrical stimulation in women with stress urinary incontinence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-20	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-7gt9pb	<NULL>	Women older than 50 years of age; Complaint of stress urinary incontinence; Never have undergone physical therapy for UI treatment.	Levels 3 or 4 pelvic prolapse; Urinary and vaginal infection; Cardiac pacemaker; Metallic implant in pelvis and femur;  Pelvic radiotherapy; Pregnancy; Surgery for urinary incontinence; Cognitive dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-3t734yn	Effects of Electrical Brain Stimulation along with Language Therapy in people with Speech Difficulties	Recruiting	Intervention	2025-09-12	<NULL>	<NULL>	8277	Effects of Transcranial Direct Current Stimulation associated with Language Therapy in patients with Expressive Aphasia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3t734yn	<NULL>	Patients with Expressive Aphasia; age between 25 and 65 years; both sexes	Changes of a psychic nature attested by medical opinion; presence of metal prostheses that prevent the application of Transcranial Direct Current Stimulation; presence of episodes of seizures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-6bjfd5	Effects of Electrical Stimulation and leg Movement with Stationary Cycling in ICU and infirmary patients	Recruiting	Intervention	2017-07-26	<NULL>	<NULL>	1308	Effects of Electrostimulation associated with Active Movement of the lower limbs with Cycloergometro in patients admitted to the intensive care unit and infirmary of the Santa Casa de Alfenas	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-08	Universidade Federal de Alfenas - UNIFAL MG	Universidade Federal de Alfenas - UNIFAL MG	https://ensaiosclinicos.gov.br/rg/RBR-6bjfd5	<NULL>	Patients with hospitalization period of at least two days; age between 18 and 50 years; both sexes, sensitivity and cognitive preserved; Glasgow Coma Scale 15; hemodynamically stable; adequate pulmonary gas exchange; Inspired fraction of oxygen less than or equal to 60% and positive pressure at the end of the expiration less than or equal to 10 cmH2O with peripheral oxygen saturation greater than 88%; Sign the Free and Informed Consent Form.	Pregnant patients; change in sensitivity; cognitive alteration; shocks; renal support; thrombocytopenia; deep vein thrombosis; agitation and confusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-25tcrt	Effects of electrical stimulation and ventilatory muscle training in patients with kidney disease on hemodialysis	recruiting	Intervention	2012-05-01	<NULL>	<NULL>	136	Effects of functional electrical stimulation and inspiratory muscle training on quality of life and functional capacity of patients with end-stage renal disease on hemodialysis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-10	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Irmandade da Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-25tcrt	<NULL>	Patients with ESRD undergoing hemodialysis more than 3 months; Urea clearance during hemodialysis (Kt / V) &gt; 1.2	Patients with recent stroke, disabling osteoarticular or musculoskeletal disease, uncontrolled hypertension (SBP &gt; 230mmHg and DBP &gt; 120 mmHg), heart failure class III or IV according to the NYHA or decompensated, uncontrolled diabetes (glicaemia &gt; 300 mg / dL), unstable angina, fever and / or infectious disease, acute respiratory failure; recent acute myocardial infarction (2 months), active smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-10jbwh47	Effects of Electrical Stimulation applied to the skin on the decrease in the blood of inflammatory cells in patients with Breast Cancer	Recruiting	Intervention	2021-03-25	<NULL>	<NULL>	4580	Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on the reduction of pro inflammatory cytokines in patients with Breast Cancer	<NULL>	2, single-arm-study, double-blind	2	<NULL>	<NULL>	<NULL>	2021-02-08	Faculdade de Medicina do ABC (FMABC)	Pesquisare Saúde	https://ensaiosclinicos.gov.br/rg/RBR-10jbwh47	<NULL>	Woman over 18 years; primary diagnosis confirmed by immunohistochemistry and biopsy; not having started chemotherapy.	Metastatic disease or bilateral breast cancer; any other malignancy in the past 5 years; biological therapy for any indication; rheumatic ot orthopedic disease; physical therapy with indication of pain or inflammation; uncontrolled cardiovascular or endocrine disease; active infection; recent major surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-8xtkjp	Effects of electrical stimulation for reduction of pain, walking ability and respiratory function in kidney donors	Recruiting	Intervention	2012-10-22	<NULL>	<NULL>	3363	Effects of transcutaneous electrical nerve stimulation on pain, mobility and pulmonary function in kidney donors	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-22	Richard Liebano	Universidade Cidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8xtkjp	<NULL>	Kidney donors submitted to the nefrectomy; aged between 18 and 70 years old and of either sex; Pain intensity at rest greater than or equal to 2 and less than or equal to 7 on a numeric verbal pain scale (0-10)	Previous TENS experience; Need for surgical intervention on another organ in addition to the kidney	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-5t27sb	Effects of Electrical Stimulation in heart Transplant patients	Recruitment completed	Intervention	2017-10-17	<NULL>	<NULL>	1428	Effects of Acupuncture with electrodes in heart Transplant patients	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Instituto Nacional de Cardiologia	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-5t27sb	<NULL>	Cardiac transplanted patients; older than 18 years; in outpatient follow-up at the National Institute of Cardiology.	Those with cardiac pacing device; intermittent cardio-defibrillator; using hearing aids; carriers of brain injury, patients with status epilepticus; patients with chronic liver disease; patients with chronic kidney disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-2ww2ts8	Effects of Electrical Stimulation in the head or ear region in adults with chronic stress	Data analysis completed	Intervention	2023-11-22	<NULL>	<NULL>	6602	Effects of Transcranial Direct Current Stimulation on the right and left dorsolateral prefrontal cortex or Non-Invasive Vagus Nerve Stimulation in adults with Chronic Stress	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2ww2ts8	<NULL>	Inclusion criteria consider individuals diagnosed with stress; Lipp adult stress symptom inventory score above 4; cognitive ability to read and interpret the purpose of the research and to respond to assessment instruments; and knowledge and consent of the free and informed consent form; Male or female volunteers aged between 20 and 50 will be recruited	Os critérios de exclusão são indivíduos fumantes; com história de tontura ou convulsão; gravidez; sinais de gravidade e/ou indicações de internação ou psicoterapia; uso de ansiolíticos; uso de antidepressivos; efeitos adversos detectados no grupo tratado com tDCS e taVNS, entre os quais coceira, formigamento, dor de cabeça, ardor, sensação e desconforto; diagnóstico de depressão; diagnóstico de ansiedade; transtorno de humor bipolar com sintomas depressivos, maníacos ou hipomaníacos no último ano; esquizofrenia ou outros transtornos psicóticos; autismo; dependência de substâncias; diagnóstico de epilepsia ou uso de anticonvulsivantes; contraindicações para a TDCS (implantes metálicos, tumor, cirurgias cerebral prévia, alteração anatômica cranioencefálica importante); contraindicações para a estimulação não invasiva do nervo vago (implante coclear, cirurgia plástica na orelha, má formação na orelha); iniciar e/ou intensidade de estimulação (mA), a largura de pulso (duração do pulso elétrico, ms), a frequência de pulso (Hz), e a relação on/off do ciclo de estímulo (medido em segundos ou minutos) são ajustados para otimizar a eficácia e tolerabilidade, porém ainda são um assunto a ser debatido.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-6wvb5c	Effects of electrical stimulation of the quadriceps muscle strength and walking capacities in patients with chronic kidney disease on hemodialysis	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	724	Peripheral effects of electrical stimulation on peripheral muscle strength and exercise capacity in patients with chronic kidney disease on hemodialysis	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2015-08-11	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6wvb5c	<NULL>	Patients with CKD diagnostic who are on dialysis regularly for at least 6 months,  stable and under medical supervision; patients without: uncontrolled hypertension, recent ischemic heart disease (3 months or less), unstable angina and severe cardiac arrhythmias; patients without diseases that limit the electrical stimulation protocol (respiratory, orthopedic and / or neurological); patients who do not do any form of physical training or who have been held for more than six months.	Inability to perform any of the study assessments (lack of understanding or collaboration); recent decompensation of the clinical picture with or without hospitalization; presence of chronic obstructive pulmonary disease (COPD or emphysema), musculoskeletal diseases that impede the realization of assessments and training protocol, uncontrolled hypertension, recent ischemic heart disease (3 months or less), unstable angina and severe cardiac arrhythmias; abnormal sensitivity in the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-9d7c7b	Effects of electrical stimulation over the skull and tight together with exercises on knee osteoarthritis	Recruiting	Intervention	2016-07-18	<NULL>	<NULL>	2371	Effects of electrical stimulation over the skull and tight together with exercises on knee osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-12	Instituto de Ciências da Saúde da Universidade Federal da Bahia	University of Sidney	https://ensaiosclinicos.gov.br/rg/RBR-9d7c7b	<NULL>	Volunteers with knee osteoarthritis; age of 50 years; knee pain on most days of the last month; osteophytes on radiographs and pain or difficulty to sit;lifting or climbing stairs ; score in Chronic Pain Grade (GPC ) equal to or greater than II.	"Subjects with contraindications to the use of transcranial magnetic stimulation; Presence of metal in the skull and implanted devices; history of epilepsy; pregnancy, use of drugs that may interfere with the cortical electrical activity; history of diseases that may interfere with OA knee; becoming confounders such as fibromyalgia; rheumatoid arthritis, ankylosing spondylitis; systemic lupus eritemotos; fractures in the region
knee, knee replacements; back problems causing symptoms in knee and peripheral nervous impairment; individuals unable to understand the contents of the assessment tools used."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-386rm8	Effects of Electro-stimulation combined with Blood Flow Restriction affected by spinal injury muscles	Data analysis completed	Intervention	2020-10-31	<NULL>	<NULL>	4358	Effect of Neuromuscular Electrostimulation combined with Blood Flow Restriction on muscle thickness and reflex responses in people with spinal cord injury	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-386rm8	<NULL>	Men volunteers with complete spinal cord injury (ASIA A) and eligible for quadriceps responsiveness.	Cauda equina injury; spinal shock; venous thrombosis; autonomic dysreflexia; vascular complications; pressure ulcers; osteoporosis; recent fracture; implants and femur metal pins and two consecutive absences to the training sessions as well.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-8f29rn7	Effects of Electroacupuncture in People with Fibromyalgia	Recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8577	Sleep, voice, and cardiorespiratory function alterations in individuals with Fibromyalgia and the effects of Electroacupuncture	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Volunteers diagnosed with fibromyalgia, characterized by pain upon palpation in at least 11 of the 18 specific tender points for more than three months, on one or both sides of the body, above and below the waist;	Having pituitary tumors or adrenal hyperplasia; epilepsy; diabetes mellitus; cardiovascular diseases; renal failure; drug or alcohol dependence; being pregnant or breastfeeding; use of a pacemaker; having undergone acupuncture sessions to treat insomnia within the past 30 days; untreated laryngeal or thyroid disease; history of respiratory, head, or neck surgery; presence of hearing complaints; self-reported smoking or alcohol consumption; being a voice professional; neurological disease; or pulmonary disease confirmed by spirometry demonstrating an obstructive ventilatory disorder; communication impairments or cognitive deficits	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-9w54gd	Effects of electroacupuncture on low back pain	Recruitment completed	Intervention	2020-11-20	<NULL>	<NULL>	4381	"Effects of electroacupuncture compared to the effects of electrical nerve stimulation
infection in nonspecific low back pain: blind randomized clinical trial."	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-14	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9w54gd	<NULL>	"Medical prescription for physiotherapeutic treatment in unspecified low back pain;
Having signed the informed consent form (ICF);
History of low back pain for more than three months;
Do not be carrying out any type of treatment."	"Three attendance absences;
Have performed surgery on the lumbar spine;
Complementary exams that show an intervertebral degenerative process.
Irradiation to one of the lower limbs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-8txf7f	Effects of Electroacupuncture on the control of Anxiety in patients undergoing wisdom tooth Extraction	Recruitment completed	Intervention	2020-05-13	<NULL>	<NULL>	3832	Effects of Eletroacupuncture in Anxiety control in patients submitted to Exodontia of third party mollars	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8txf7f	<NULL>	Included in the study were patients with ages ranging from 18 to 60 years; of age who were literate and in possession of the mental faculties; and who wanted to participate in the study; diagnosed with indication for bilateral third molar extraction; asymptomatic and in similar surgical positions and difficulties; analyzed through panoramic radiographs	Patients younger than 18 years of age; classified as ASA III or IV; history of drug use for pain or anxiety within 15 days prior to initiation of the survey; history of hypersensitivity to drugs, substances or materials used in this experiment; pregnancy or lactation or with prior history of pericoronitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-4cwps2	Effects of electrostimulation in patients with chronic pain from HIV	Data analysis completed	Intervention	2020-06-23	<NULL>	<NULL>	3938	Effects of Interferential Current upon HIV neuropathic pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-02	Universidade La Salle	Universidade La Salle	https://ensaiosclinicos.gov.br/rg/RBR-4cwps2	<NULL>	Women with HIV/AIDS; aged between 18 and 65 years; in antiretroviral therapy; have neuropathic cervicalgia, confirmed by LANSS scale.	Active contagious infection (meningitis, pulmonary tuberculosis); history of chronic diseases associated with neuropathic pain (diabetes, lupus, rheumatoid arthritis, infection by Human T-cell Lymphotropic Virus); chronic renal or peripheral vascular insufficiency; oncologic disease; severe disease that limits the understanding of the informed consent or tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-3zs6g9	Effects of equine therapy on postural balance, gait, performance and functional mobility and quality of life in healthy people and people with disability	Not yet recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2149	Evaluation of the stimuli produced by the intervention with equine therapy on the kinetic and kinematic variables of healthy and pathological subjects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-12	Universidade de Brasilia	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3zs6g9	<NULL>	"The volunteers should be have more than 6 months after stroke; have a level 3 or higher in the
Functional Ambulation Category (FAC) -
walk independently or with the help of a third party; have a score higher than
24 in the Mental State Mini Exam or appropriate score in case of
illiterates.
For subjects with multiple sclerosis: The inclusion criteria adopted were: women aged between 20 and 60 years; confirmed medical diagnosis of multiple sclerosis in its most frequent form (referent-recurrent); rated between 1.0 and 3.0 by the EDSS scale."	"Diagnosis of Bilateral Stroke with double hemiparesis; uncorrected visual or auditory deficiency;
comorbidities that may interfere with the equotherapeutic treatment, for example,
psychiatric problems, cognitive deficit with apraxia, aphasia with inability to
follow simple commands; patients with active cardiovascular diseases;
uncontrolled diabetes and weight greater than 97 kg; have practiced activity
in the last 6 months;
For subjects with multiple sclerosis:The exclusion criteria were: having had an outbreak in the last 30 days; presence of infectious and neoplastic diseases; have musculoskeletal disease in the lower limbs that compromises the performance of the tests; associated neurological diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-9bqqpc8	Effects of Erbium Laser on Facial Rejuvenation	Data analysis completed	Intervention	2025-12-05	<NULL>	<NULL>	8622	Effect of Er:YAG laser on labial and buccal mucosa	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	<NULL>	<NULL>	<NULL>	Males and females aged 35 to 70 years; in good general health; willing to adhere to the study protocol; presenting a chief complaint of aesthetic dissatisfaction with their lips; and pronounced nasolabial folds	Previous application of fillers or botulinum toxin in the region at any given moment; the possibility and/or presence of pregnancy; active oncologic treatment; and other conditions that lead to alterations in circulatory and or metabolic systems	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-7zphsf	Effects of Evaluation of Exercise Capacity at the level of daily physical activities of adults of the community	Not yet recruiting	Intervention	2019-05-06	<NULL>	<NULL>	2659	Effects of the Avaluation of Cardiorrespiratory Fitness at the level of activity and physical fitness of adults of the community	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal São Paulo	Universidade Federal São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zphsf	<NULL>	Age from 18 years; without diagnosis of cardiorespiratory, metabolic or neuromuscular diseases that prevent the performance of physical exercises	Basal cardiorespiratory fitness greater than 9 METs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-26qdtg	Effects of everolimus (Certican) on cardiac hypertrophy and carotid atherosclerosis after kidney transplantation	Recruiting	Intervention	2014-01-16	<NULL>	<NULL>	271	Effects of Everolimus (Certican) on cardiac hypertrophy and carotid atherosclerosis after kidney transplantation	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2012-05-09	Hospital das Clínicas da Faculdade de Medicina de Botucatu	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-26qdtg	<NULL>	The patient who agree to participate in the study, who have a consent form signed and meet the following criteria: age of 30 years or greater and being a recipient of de novo kidney transplant from a deceased donor or non-HLA identical living donor. At randomization time the patients needs to meet this criteria: creatinine clearance estimated by Cockroft-Gault formula of 40ml/min or greater and proteinuria of 800mg/day or less.	Patients will be excluded of the study if: with painel reactive antibody of 50% or higher, recipients of a second transplant with the first transplant loss for any immunological cause within the first year of transplantation, multi-organ recipient, ABO incompatible donor; non-beating heart donor; donor age of 5 yars or less and donor age of 65 years or higher. At the randomization  time, patients will be excluded if: they were on a rejection treatment, if they have history of Baff IIB or higher rejection insult, previous rejection resistant to corticosteroids, presence of subclinical rejection or severe inflammation on protocolar biopsy, presence of total blood cont leucocyte of 2500uL or less, neutrofiles of 1500uL or less, platelets of 75000uL or less, hemoglobin of 6,0g/L or less, liver disease or active infection, positive pregnancy test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-10fghxtm	Effects of exercise and antioxidant supplementation in individuals with diabetes kidney disease	Withdrawn	Intervention	2021-11-30	<NULL>	<NULL>	5148	Controlled and randomised clinical study on the effects of exercise associated with antioxidant supplementation on redox and immuno-metabolic regulation in patients with diabetes renal disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10fghxtm	<NULL>	Female and male; ages 40 to 65; staging of chronic kidney disease 3 and 4 degree; body mass index: lower than obesity grade 2; glomerular filtration rate estimated by the equation developed by Chronic Renal Disease Epidemiology Collaboration (CKDEPI) and according to stage 3 and 4; presence of optimized drug therapy and without the prediction of change in drug doses of renin-angiotensin aldosterone system blockers, mineralocorticoid antagonist or sodium cotransporter inhibitors and glucose with stable doses up to 4 weeks prior to randomization and during the 7 months of intervention.	Heart failure; severe coronary heart disease indicating physical activity or cardiovascular surgery (e.g. coronary bypass, valvar exchange or angioplasty) within the last 6 months; uncontrolled cardiovascular disease; percentage of glycated haemoglobin greater than 9; chronic lung disease; active viral infections; neurological and mental disorders, musculoskeletal impairment that prevents physical exercise, malignancy (except epidermoid carcinoma) or debilitating and warfarin users.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-94529v	Effects of exercise and athletic tape in patients with lumbar disc herniation	Recruiting	Intervention	2019-10-22	<NULL>	<NULL>	3122	Effects of segmental stabilization and functional elastic bandage in patients with lumbar disc herniation	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-06-04	SOBEU - Associação Barramansense de Ensino	SOBEU - Associação Barramansense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-94529v	<NULL>	Both genders; age between 18 and 59 years; lumbar disc herniation proven by computed tomography or nuclear magnetic resonance; pain 3 cm or more according to the numerical pain scale (NDE) for at least 3 months; not being under physical therapy	Under 18 and over 59 years old; pain less than 3 cm according to the numerical pain scale (NDE); pain for less than 3 months; previous spinal surgeries; neurological disorders; asymptomatic, extruded, thoracic or cervical herniated disc; impediment to perform the exercises; cognitive inability to participate in the evaluations or perform the proposed treatments; allergic processes of the bandage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-85d58z	Effects of exercise and athletic tape on the arm of stroke patients	Recruiting	Intervention	2019-06-21	<NULL>	<NULL>	2777	Effects of Kinesiotherapy and Elastic Functional Banding on the upper limb of spastic hemiparetic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-03	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-85d58z	<NULL>	Volunteers with active wrist movements; spasticity grades 1 to 3 in the flexor muscles of wrist and fingers 2nd Modified Ashworth Scale; medical indication for physiotherapeutic care; injury for more than 6 months; adequate comprehension skills and communication skills.	Volunteers who present with allergic processes to functional elastic bandage; degrees 0 or 4 of spasticity according to the Modified Ashworth Scale; Wernicke&apos;s aphasia; other associated neurological pathologies; history of lesions that preclude joint movements on the side of the paresis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-5pw6crc	Effects of exercise and chess in decision making of adolescents	Recruitment completed	Intervention	2022-08-12	<NULL>	<NULL>	5549	Effects of aerobic exercise and chess in executive function of adolescents: a randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-5pw6crc	<NULL>	Sedentary (without regular physical activity for the last six months); wanting to learn how to play chess; avaliability to participate in the evaluations and interventions.	motor impairment or stroke; presenting neurological diseases that interfere in cognition and/or mobility.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-5ns6sg	Effects of Exercise and Diet on the Functional Status, Nutritional Status, Lipid Profile and   Life&apos;s Quality in Hemodialysis patients	Recruiting	Intervention	2015-06-21	<NULL>	<NULL>	518	Effects of Exercise and Nutritional Intervention on the Functional Status, Nutritional Status, Lipid Profile and   Life&apos;s Quality  in hemodialysis patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5ns6sg	<NULL>	155 patients of both sexes; aged 20 and 79; for at least three months in haemodialysis treatment; sedentary; kidney therapy performed through access fistula; and adequacy of treatment of haemodialysis (Kt/V&gt;1.2.	patients with disability and severe orthopedic impairments; acute myocardial infarction history in the last six months; recent hospitalization (&lt;3 months; decompensated diabetes; consuming vitamin supplement; which have thyroid dysfunction; and patients who have food intolerance baru.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8sxnfyd	Effects of Exercise during hospital stay in pediatric Cancer patients	Recruiting	Intervention	2023-01-25	<NULL>	<NULL>	5842	Protocol of Therapeutic Exercises during hospital admission in pediatric Oncohematological patients: a randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Centro Universitário Faculdade de Medicina do ABC	Centro Universitário Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8sxnfyd	<NULL>	Individuals between 8 and 17 years old; with diagnosed oncohematological disease; hospitalized in a pediatric ward; both sexes; clinically compensated participants with respiratory, cardiac or musculoskeletal pathologies prior to cancer diagnosis; that they accept to participate in the research and those responsible sign the informed consent form and that the participant signs the informed consent form	Participants with cognitive alterations that make the assessment impossible; participants who present one or more of the following criteria: body temperature &gt; 38ºC, pain with a visual analogue pain scale  of 5 or above, constant diarrhea, uncontrolled bleeding, tachycardia and/or hypotension (mean arterial pressure - MAP less than 60); participants with blood count alterations less than 8.0mg/dl and symptoms of decompensation and platelets less than 20.000/mm3	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-4xqpmm	Effects of exercise for chronic kidney patients during hemodialysis.	Recruitment completed	Intervention	2020-02-26	<NULL>	<NULL>	3527	Effects of a combined intradiiality exercise program in patients with chronic renal disease: randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4xqpmm	<NULL>	Inclusion: age over 18 years; due to the ease of travel and use of the consent form; being more than three months on hemodialysis, due to treatment adaptations; does not present any type of motor impairment that makes it impossible to evaluate and perform the exercise protocol, for patient and researcher safety. The conditions will be submitted to the medical staff of the renal replacement therapy unit; do not use medical contraindications for physical exercise; cognitive ability to understand the research process and sign the consent form; willingness to participate in the study.	Exclusion: Known unstable medical condition (angina, uncontrolled hypertension, congestive heart failure, arrhythmogenic heart disease); Neuromuscular disorders (myasthenia gravis, amyotrophic lateral sclerosis, congenital muscular dystrophies, cerebellar ataxias); Pacemaker carriers; Stop voluntarily participating in the study; Do not perform exercise sessions for two consecutive weeks; Discharge or abandon treatment; Not being collaborative in the proposed evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-8fdmb8	Effects of exercise in postmenopausal women	Data analysis completed	Intervention	2015-04-07	<NULL>	<NULL>	440	Impact of exercise on risk factors in overweight and obese postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-11-30	Universidade Estadual Paulista Júlio de Mesquita Filho de Presidente Prudente - SP	Universidade de Marília	https://ensaiosclinicos.gov.br/rg/RBR-8fdmb8	<NULL>	We included 70 women aged 50-79 years; postmenopausal (no period for at least twelve months); obese (fat percentage&gt; 33%); previously sedentary (&lt;150 minutes per week of moderate or vigorous physical activity in the past six months); all users of the Family Health Unit (USF); and no medical restrictions for physical exercise.	Introduced during the intervention health problems that limit or prevent the implementation of the exercise program; anyone associated with inflammatory responses such as influenza; diseases; recent surgical procedures; and acute arthritis condition; less than 65% frequency in the proposed interventions; not accomplish all assessment procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-4nzjmt	Effects of exercise in the perineal region through the use of an application in pregnant women	Not yet recruiting	Intervention	2018-12-18	<NULL>	<NULL>	4479	"Effects of pelvic floor muscle training with
mobile app in pregnant women"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4nzjmt	<NULL>	Age over 18 years; Gestational age of 16 weeks gestational; Primiparae; Presence of pelvic lining muscle strength greater than 2 by the Modified Oxford Scale; Medical authorization for physical therapy intervention; Own the mobile device with android system; • Own the mobile device with android system; Have an understanding of the functioning of the application developed by the research team; Have internet when downloading the application and for the call center; Understand the use of the platform used for the call center	Multiple gestation; Presence of bone deformities, important muscular and nervous dysfunctions; Presence of high gestational risk; Perform previous pelvic floor muscle training;; Lower urinary tract infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-4m3k2c	Effects of exercise in the treatment of depression, dementia and parkinson.	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	2593	Effectiveness of exercise in the treatment of major depression, Alzheimer&apos;s disease and Parkinson&apos;s disease.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-13	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4m3k2c	<NULL>	Seniors over 60 years. both sexes. diagnosed with major depression. Alzheimer&apos;s disease. Parkinson&apos;s disease.	Cerebrovascular infarction history. use of treatments such as electroconvulsive therapy. psychotherapy, illiterate and functional class III and IV according to the criteria of the New York Heart Association.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-94v6kd	Effects of Exercise of the Respiratory Muscles with Different Types of Devices in People with Chronic Obstructive Pulmonary Disease	Not yet recruiting	Intervention	2016-11-23	<NULL>	<NULL>	1076	Effects of Respiratory Muscle Training with Different Modalities in Patients with Chronic Obstructive Pulmonary Disease (COPD) - Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal  do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes - HUOL	https://ensaiosclinicos.gov.br/rg/RBR-94v6kd	<NULL>	Follow up with a specialized pulmonology physician, aged between 40 - 80 years, living in city of the study, not in use of oxigenoteraphy or disease exacerbation in the last three months, not practicing regular physical activity in the last six months will be eligible to participate.	Musculoskeletal comorbidities that interfere with the march ; which decreased the oxygen saturation ( SpO2) &lt;90 % during cardiopulmonary exercise testing ; who had difficulty intellectual understanding that prevented them from performing evaluation activities ; abandon the proposed therapeutic program ; missing the proposed activity over one week or they do not appear to the re-evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-26kn3b	Effects of exercise on a stationary bicycle combined with training of the respiratory muscles in individuals with Parkinson&apos;s disease.	Recruiting	Intervention	2019-11-21	<NULL>	<NULL>	3208	Comparison between training of upper limb respiratory and peripheral resistance on the respiratory function of patients with Parkinson&apos;s disease: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-14	Instituto de Ciências da Saúde da Universidade Federal da Bahia	Clínica Escola de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-26kn3b	<NULL>	Being on regular medication for Parkinson&apos;s disease; being on the medication &quot;on&quot; period; have age greater than or equal to 50 and less than or equal to 80 years; present stage 2, 2.5 or 3 according to the Hoehn and modified Yahr classification.	To present neurodegenerative diseases excluding Parkinson&apos;s disease; osteomioarticular diseases that make it impossible to practice physical activity; chronic non-controlled diseases (hypertension, diabetes mellitus, chronic pain); unstable cardiovascular diseases (acute heart failure, recent myocardial infarction, unstable angina and uncontrolled arrhythmias); use of alcohol and other toxic substances; practicing or practicing a physical exercise program in the last 6 months; or participate in or participate in regular resistance training (2-3 times per week) in the previous 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-6ffm72	Effects of exercise on nerve action that controls the muscle fibers and blood vessels of patients with pre-dialysis chronic kidney disease	Data analysis completed	Intervention	2015-06-05	<NULL>	<NULL>	501	Effect of aerobic exercise on muscle sympathetic nerve activity in predialysis chronic renal	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Faculdade de Medicina da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6ffm72	<NULL>	21 Men and women; between 30 and 60 years; Without participation in structured physical activity; not obese; nondiabetic. They were divided into 2 groups: Control (normotensive patients) and Chronic renal disease, stage III (creatinine clearance 30 to 60 mL / min / 1.73m2, hypertensive controlled in use of angiotensin converting enzyme inhibitors or  Angiotensin receptor antagonists).	Patients with anemia; in the chronic kidney disease group, we excluded patients who were taking beta-blockers and sympatholytic. And also with creatinine clearance &lt;30 and&gt; 60 mL / min / 1.73m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-8t2p2m	Effects of Exercise on stationary bicycle in Hemodialysis Patients	Recruitment completed	Intervention	2017-10-26	<NULL>	<NULL>	1444	Effects of intradialitic aerophonal exercise with partial restriction of blood flow in patients in hemodialysis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Escola Superior de Educação Física/Universidade Federal de Pelotas	Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8t2p2m	<NULL>	patients with chronic kidney disease on hemodialysis; 18 years of age or over; both sexes.	With previous diagnosis of coronary artery disease; submitted to mechanical ventilation and hospitalized in the intensive care unit; with musculoskeletal limitation that impedes the performance of the exercise; with cognitive alterations that make it impossible to understand the instructions of the exercises; pregnant women; individuals with a history of deep venous thrombosis; with systolic blood pressure greater than or equal to 180 mmHg or greater diastolic equal to 105 mmHg at rest and resting heart rate greater than or equal to 120 bpm at rest; practitioners of any physical exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-7hh489b	Effects of exercise on strength of Colorectal Cancer patients undergoing Chemotherapy	Not yet recruiting	Intervention	2023-05-17	<NULL>	<NULL>	6086	Effects of co-contraction training on neuromuscular, biomolecular, and functional parameters in Colorectal Cancer patients undergoing Chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7hh489b	<NULL>	Men and women over the age of 18; diagnosed with colorectal cancer; undergoing chemotherapy treatment; with access to a tablet, smartphone, laptop, or computer with an integrated video camera; and willing to appear on camera during exercise sessions to enable safety monitoring	Diagnosis of cardiovascular disease and neurodegenerative diseases; presenting any other health problem that interferes with the execution of the proposed exercises and evaluations; history of neuromuscular injury in the upper and lower limbs in the last 12 months; not being considered able to participate in the study after medical evaluation; refusing to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-2t5hntp	Effects of Exercise on the Health of Hemodialysis Patients	Recruitment completed	Intervention	2024-08-09	<NULL>	<NULL>	7195	Effects of a Strength or Endurance Exercise Program on the Clinical Parameters of Hemodialysis Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-22	Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-2t5hntp	<NULL>	Voluntary and consented participation; being on hemodialysis for more than three months; not present physical and motor impairments that make it impossible to perform the exercise; not have any type of medical contraindication that would make the intervention unfeasible; adult men and women; age between 18 and 59 years old; without distinction of race or ethnicity; have authorization from the medical team at the health center responsible for the patient	Severe physical disability; osteoarticular complications that do not allow training to be carried out; recent history of acute myocardial infarction; failure to sign the agreement; severe cognitive impairment that prevents them from understanding instructions given and carrying them out safely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-275ybt	Effects of Exercise Program on Work Environment	Data analysis completed	Intervention	2016-04-10	<NULL>	<NULL>	794	Effects of Workplace Exercise Program: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-275ybt	<NULL>	Volunteers of both sexes aged between 25 and 50 years; which they were in accordance with the methods and signed the informed consent form ; who worked in the factory production area.	Disability or depressive autorelato .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-4v2r4bg	Effects of exercise to prevent diastasis in pregnant women	Recruitment completed	Intervention	2021-09-20	<NULL>	<NULL>	5994	Effect of physical therapy intervention to prevent abdominal diastasis in pregnant women: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-24	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4v2r4bg	<NULL>	Age group between 18 and 40 years old; Primitives or with previous pregnancies that ended before the 21st gestational week; Single pregnancy; Gestational age between 18 and 21 weeks; Not having undergone previous abdominal surgery; Presentation of a certificate from the physician, responsible for prenatal care, of release for the practice of physical exercises.	Presence of high gestational risk; Presence of bone deformities; Presence of major muscle dysfunctions; Presence of neurological and/or cognitive deficiencies that prevent the understanding of the proposed procedures; Being visibly under the influence of drugs or alcohol; Missing two consecutive intervention sessions; Termination of pregnancy before the last assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-7fnbz7	Effects of exercise training on cardiovascular risk factors in HIV patients	Recruiting	Intervention	2017-05-12	<NULL>	<NULL>	1231	Prevalence and effects of aerobic training on cardiovascular risk factors in HIV patients taking antiretrovirals from the metropolitan region of Porto Alegre	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7fnbz7	<NULL>	HIV+ subjects on a stable HAART regimen for at least 3 months before enrollment; he viral load should be less than 50 copies/mL blood and they should not practice any exercise regularly for, at least, six months before to start the training protocol.	Subjects with a previous history of neurological disease; antioxidant supplements, tobacco and/or drug use, physical and/or mental disability and pregnant women were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-3yxds4	Effects of exercise training on the human body	Recruiting	Intervention	2016-09-22	<NULL>	<NULL>	1018	Time-course of organic adaptations in response to exercise training in aging	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas	Programa de Pós-Graduação em /gerontologia, Faculdade de Ciências Médicas, UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-3yxds4	<NULL>	Individuals from both sexes; non-active (frequency of regular physical activity less than two sessions per week); Did not participate in any regular training program over the last 6 months preceding the beginning of the experiment; to be normotensive, or grade 1 (systolic blood pressure: 140 to 149 mmHg or diastolic blood pressure: 90 to 99 mmHg), or 2 (systolic blood pressure 160 to 169 mmHg or diastolic blood pressure: 100 to 109 mmHg) of controlled hypertension (according to the medical report of the participants);  have clinical evaluation report carried out by a physician (general physical examination, cardiological and clinical exercise testing) authorizing the practice of physical activity.	Obesity greater than grade 2 (body mass index up to 35); coronary artery disease, diabetes mellitus insulin-dependent; chronic obstructive pulmonary disease; limiting osteoarticular disease; peripheral vascular disease; smokers; in use of medications that may interfere with physiological responses to tests, such as beta-blockers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3dp727r	Effects of Exercise Training with body weight in Hypertensive individuals	Not yet recruiting	Intervention	2023-08-16	<NULL>	<NULL>	6355	Acute and chronic effects of Exercise Training with body weight in Hypertensive individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de São Paulo	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-3dp727r	<NULL>	The inclusion criteria will include individuals who: are male; are hypertensive through a previously requested medical report; whose hypertension is controlled by medication; are between 30 and 50 years old; have been sedentary for at least a period of 6 months; hold medical clearance to practice physical exercise; do not present injuries that limit the partial or total practice of physical exercise; agree to be volunteers for the realization of this project; provide personal and health information; perform pre-participation assessments of the exercise program; sign the free and informed consent form (TCLE)	Participants who change their drug treatment during their participation in the research and who, during the 17-week training period, have a frequency below 75% will be excluded from the analyses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-9cbp8s	Effects of exercise training with power control in muscle strength, cholesterol and body fat postmenopausal women	Recruitment completed	Intervention	2016-04-04	<NULL>	<NULL>	3220	Effects of physical training and diet control on muscle strength, cardiorespiratory fitness, biochemical variables and body composition in postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9cbp8s	<NULL>	Female volunteers; aged between 50 and 65 years; present in the menopausal period without menstruation for 1 year or more; possess a medical certificate to perform the tests required and participate in the training program.	Present physical limitations or any health problems that prevent the implementation of the evaluation or bodily practices; accumulate three consecutive unexcused absences or 4 unexcused absences during the month of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-8xkwyp	Effects of exercise using video game and nutritional guidance on musculoskeletal function in older women	Recruitment completed	Intervention	2016-02-18	<NULL>	<NULL>	1117	Effects of video game physical training and nutritional orientation on functional capacity of older women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-08	Uiniversidade Federal do Paraná - UFPR	Instituto Federal do Paraná - IFPR	https://ensaiosclinicos.gov.br/rg/RBR-8xkwyp	<NULL>	Independent older women, 65 years and over; residents in the Curitiba city and metropolitan area, Parana, Brazil; inactive or moderately active; without cognitive impairment according to the Mini mental state examination	Volunteers with diagnosis of neurological disease and/or trauma and orthopedic fixation or prosthesis with metallic or non-metallic implants, cardiac, respiratory, kidney, liver, osteoporosis, diabetes, hypertension and endocrine decompensated; obese; use of medications that affect balance; visually impaired without the use of visual correctors; voluntary unavailable to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-3623xj	Effects of exercise with blood flow restriction (BFR) associated with photobiomodulation (PBM) on muscle performance	Recruiting	Intervention	2019-12-03	<NULL>	<NULL>	4802	Effects of exercise with blood flow restriction (BFR) associated with photobiomodulation (PBM) on muscle performance,  inflammation and oxidative stress	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-30	João Vitor Ferlito	Centro Universitério CNEC de Bento Gonçalves	https://ensaiosclinicos.gov.br/rg/RBR-3623xj	<NULL>	Male. Between 18 and 40 years old and do not be realizing resistance training in the previous three months	Use of supplementation. History of cardiovascular diseases. History of deep venous thrombosis. Smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-78rngkv	Effects of Exercise, Electrical muscle stimulation and Pain education on psychological, functional and muscular parameters of patients with low back pain, classified by risk of poor prognosis	Recruitment completed	Intervention	2023-09-19	<NULL>	<NULL>	6450	Effects of Lumbopelvic stabilization, Neuromuscular electrostimulation, Imagery, and Pain education on psychosocial, functional, and neuromuscular parameters of patients with Chronic low back pain, stratified by risk of poor prognosis: randomized clinical trial	<NULL>	array, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-06	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-78rngkv	<NULL>	group control; age between 18 and 59 years; physically inactive; deny history of systemic diseases that limit or contraindicate the walk tests; or chronic or acute musculoskeletal disorders in the lower limbs and/or spine; chronic low back pain groups; age between 18 and 59 years; physically inactive; persistent low back pain for more than three months; physical characteristics compatible with mechanical etiology according to the evaluation and treatment guidelines proposed by the American College of Physicians and the American Pain Society	History of spinal surgery; pregnancy; lack of safe hemodynamic conditions for walking or clinical tests; significant increase in pain during the tests, making walking an intolerant activity according to the volunteer&apos;s perception; worsening of the chronic condition on the day of the test; symptoms of acute illnesses such as colds and flu; body mass index greater than 35.0	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-26q4z9	Effects of exercises with action observation and aquatic physical therapy in arm recovery after stroke	Recruitment completed	Intervention	2016-03-23	<NULL>	<NULL>	3223	Comparative study between action observation training and hydrotherapy in upper limb recovery after stroke: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Federal de Mato Grosso do sul	Universidade Federal de Mato Grosso do sul	https://ensaiosclinicos.gov.br/rg/RBR-26q4z9	<NULL>	Sample consists of 60 adult participants with a minimum age of 40 years and maximum age of80 years. Inclusion criteria: diagnosis of a single episode of ischemic or hemorrhagic stroke occurred between 3 months and 2 years in good health condition; with brachial- facial hemiparesis; with mild to moderate and independent walking even under use of any assistive device for ambulation	Exclusion criteria: more than one episode of stroke; with evidence of lesions in the cerebellum; brainstem or bilateral hemispheric injury. Aphasia; clinically unstable and comorbidities that interfere with motor function and severe spasticity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7fh22d	Effects of exergame and resistance training on reaction time, functional fitness and quality of life in older adults	Recruitment completed	Intervention	2019-06-07	<NULL>	<NULL>	2729	Active videogame and resistance training in older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-06	Universidade Federal de Santa Catarina	Centro de Deportos da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7fh22d	<NULL>	Individuals of both sexes (target sample = 36 subjects); aged 50 years or older; not participating in regular exercise programs in the last month; not participating in active videogames in the last 12 months; people without visual and hearing impairment, which may hinder the identification of colours, images and sounds.	Diagnosis of Alzheimer&apos;s disease; Parkinson&apos;s disease; disabling neurological diseases; psychiatric comorbidities; neurodegenerative diseases; severe cardiovascular or metabolic disease; orthopedic injury that makes it difficult or impossible to carry out the proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-6xhtgj8	Effects of exergame physiotherapy on clinical-functional outcomes, hemodynamic parameters and epigenetic markers in sedentary hypertensive elderly women	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7082	Effects of kinesiotherapy intervention with exergame on clinical-functional outcomes, hemodynamic parameters and epigenetic markers in sedentary hypertensive elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Universidade de Passo Fundo	Universidade Regional Integrada do Alto Uruguai e das Missões	https://ensaiosclinicos.gov.br/rg/RBR-6xhtgj8	<NULL>	Being female. Be aged 60 or over. Have the ability to walk. Be sedentary according to the World Health Organization  WHO 2018 classification  practicing less than 150 minutes of moderate physical exercise per week. Have a previous diagnosis of hypertension, have been using antihypertensive medication for at least three months and are not in a hypertensive crisis Systolic Blood Pressure  SBP maior que 180 milímetros de mercúrio mmHg and Diastolic Blood Pressure  DBP maior que 120 milímetros de mercúrio mmHg. Present a preserved cognitive aspect, according to the results of the Montreal Cognitive Assessment - MoCA  above 26 points. Participants who do not reach the minimum score will normally participate in the study, but will not be included in the data analysis	Inability to communicate with investigators. Present a high risk of deep vein thrombosis. Grade II and III obesity Body mass index BMI≥35 kg/m2. Participants who do not achieve 75% attendance at meetings. Patients with a cardiac pacemaker. Present depressive symptoms (above 6 points) according to the results of the geriatric depression scale (GDS-15). Have a previous diagnosis of oncological, rheumatological, cardiovascular diseases (except SAH), kidney disease resulting from Systemic Arterial Hypertension - SAH or with cardiovascular, neurological, psychiatric and/or cognitive, immunological and hematological repercussions. Patient on continuous use of hypoglycemic medications. Patients with reduced mobility (range of movement)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-8rtjmd	Effects of exergames and traditional exercise on anxiety in women after exposure to unpleasant stimuli	Not yet recruiting	Intervention	2020-05-19	<NULL>	<NULL>	3848	Acute Effects of Exergames and Traditional Continuous Exercise on Anxiety-State Levels in young women after exposure to Unpleasant Stimuli	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8rtjmd	<NULL>	woman; aged between 18 and 40 years old	Body mass index equal or greater than 30 kg/m2;  to be in the menstrual period; to have contraindications for physical activity; to be undergoing any kind of anxiolytic treatment; to be illiterate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-43j2rh9	Effects of Extra-articular Reinforcement in Anterior Cruciate Ligament Reconstruction on the clinical and functional status of high-performance athletes	Not yet recruiting	Intervention	2025-04-08	<NULL>	<NULL>	7902	Effects of ACL Reconstruction on the functionality of high-performance athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	https://ensaiosclinicos.gov.br/rg/RBR-43j2rh9	<NULL>	Be a federated athlete who has participated in one or more official competitions in the last two years; be between 18 and 45 years old; have an injury to the Anterior Cruciate Ligament – ACL, without compromising other ligament structures of the knee; have not undergone previous surgery on the affected joint; of either sex	Presence of post-surgical infection; inability to or refusal to perform follow-up assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-54x2zpz	Effects of facilitated restraint on cerebral oxygen consumption during the suction of secretions present in the nostrils and throat of preterm newborns	Recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7771	Acute effects of aspiration in preterm newborn with or without facilitated contention on cerebral oxygen consumption: a randomized crossover clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2024-12-01	Faculdade de Medicina da Universidade de São Paulo	Hospital Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-54x2zpz	<NULL>	Newborns under 35 weeks admitted to the Neonatal Intensive Care Unit; both genders; monitored with brain near-infrared light spectroscopy	Congenital Heart Disease; diaphragmatic hernia; fracture of upper limbs or lower limbs; use of sedation or analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-10qc32q5	Effects of fascial release with electric massager	Recruitment completed	Intervention	2021-05-29	<NULL>	<NULL>	4700	Acute effects on skeletal muscle fascia after myofascial release session with portable electric massager at different frequencies	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10qc32q5	<NULL>	Being between 20 and 50 years old; Availability to participate in data collection; Not having muscle damage in the muscle being evaluated; freely consent to their participation by signing the informed consent form	Participants diagnosed with joint and/or muscle disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:34
RBR-24db7p7	Effects of firefighting simulation on mental performance and functions of blood vessels and heart rate	Recruitment completed	Intervention	2023-04-28	<NULL>	<NULL>	6039	Effects of firefighting simulation on cognitive performance and vascular and autonomic functions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-27	Universidade Federal de Santa Catarina	Corpo de Bombeiros Militar de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-24db7p7	<NULL>	Firefighters with at least 3 years of experience who are taking the sergeant training course; both genders; minimum age 18 years	People with cardiovascular disease; mental disorders; metabolic diseases; infectious diseases; inflammatory diseases; muscle injuries; joint injuries; smokers; taking medicines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-4njyw9	Effects of fish oil supplementation  on pre diabetes in patients with chronic hepatitis C.	recruiting	Intervention	2012-06-05	<NULL>	<NULL>	94	Effects of omega 3 fatty acids supplementation  on insulin resistance in patients with chronic hepatitis C.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-05	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4njyw9	<NULL>	Adults (age &gt; 18 years) diagnosed with chronic hepatitis C (genotype I); either non responders or naive patients; alcohol consumption &lt; 40g/dia; HOMA index &gt; 2.5; Signature of term consent	Diabetics or those using drugs to alleviate insulin resistance, co-infected (HIV or HBV), hepatitis with autoimmune or use of antiviral treatment (interferon and ribavirin), decompensated liver disease or patients with hepatocellular carcinoma; With other neoplasias; Patients with chronic renal failure or decompensated heart failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-767cyvb	Effects of Florals on anxiety, quality of sleep and quality of life of medicine students	Data analysis completed	Intervention	2025-09-23	<NULL>	<NULL>	8305	Evaluation of the effects of Floral Essences on anxiety, quality of sleep and quality of life of medicine students from a university in south Brazil: a clinical trial randomized and controlled	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-08	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-767cyvb	<NULL>	Healthy medical students; from UNISUL; who do not have any diagnosed disease and/or are not undergoing treatment; both genders	Students with immunosuppressive diseases; oncological diseases; infectious diseases; or in a febrile state; epilepsy; diagnosed with depression; pregnant and/or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-48kjwtj	Effects of food and nutrition education activities on food consumption, nutritional status and cardiovascular health in family members of overweight children	Recruiting	Intervention	2022-07-05	<NULL>	<NULL>	5465	Effects of a food and nutritional education program on food consumption, nutritionaal status and cardiometabolic parameters in family members of overweight and obesity  children  in the municipality of Vitória de Santo Antão	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-48kjwtj	<NULL>	Family members or adult family members, aged 20 and less than 60 years; Living in the same household as children aged 7 to 10 years that are enrolled in the municipal education network of Vitória de Santo Antão.	Family members who do not live in the same household as the child; Family members who have pathologies that may affect their nutritional status and/or food consumption, such as cancer; acquired immunodeficiency syndrome; liver diseases; Pregnant women; family members who do not adhere to the food and nutrition education program or who give up during the course of the proposed intervention;  Participants who are absent in more than twenty five percent of the meetings, that is, in more than 2 meetings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-82rpdv9	Effects of food supplementation with vegetable oils containing Medium Chain Triglycerides on the nutritional status and development of inflammation in patients with elephantiasis	Data analysis completed	Intervention	2024-03-13	<NULL>	<NULL>	6852	Effects of dietary supplementation with different levels of Medium-chain Triglycerides on the nutritional status and inflammatory response of patients with Lymphatic Filariasis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Federal de Pernambuco	Instituto Aggeu Magalhães - Fiocruz Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-82rpdv9	<NULL>	Patients registered at the National Reference Service for Filariasis (Fiocruz-PE); residents in an endemic area for lymphatic filariasis; of both genders; aged between 18 and 85 years old, who had lymphedema of the lower limbs	Patients with edema or lymphedema due to liver diseases, neoplasms, congenital lymphatic alterations, cardiac and/or vascular insufficiencies, who, after medical screening, have no indication for follow-up at the Serviço de Referência Nacional em Filarioses (Fiocruz Pernambuco); patients who were already undergoing nutritional monitoring outside Fiocruz Pernambuco, or who had neurological and/or psychiatric diseases that could make it difficult to understand dietary guidelines; pregnant and/or lactating patients; patients who reported rejections, intolerances or allergies to the use of medium chain triglyceride oil as well as coconut oil	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-6p83pjb	Effects of fortified protein supplementation and influence of single nucleotide polymorphisms: nutritional status and food behavior of patients underwent to bariatric surgery	Recruiting	Intervention	2023-10-01	<NULL>	<NULL>	6473	Nutritional status and eating behavior of patients undergoing bariatric surgery: effects of fortified protein supplementation and influence of nucleotide polymorphism	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Universidade Federal de Goiás	Hospital Geral de Goiânia Doutor Alberto Rassi	https://ensaiosclinicos.gov.br/rg/RBR-6p83pjb	<NULL>	Women undergoing bariatric surgery, aged between 18 and 65 years; women; body mass index greater than or equal to 40 kilograms per cubic meter; body mass index greater than or equal to 35 kilograms per cubic meter associated with comorbidities	Women in pregnancy or lactation; volunteers in a situation of tobacco or nicotine dependence; situation of chronic abuse of alcohol and/or illicit drugs; confirmed diagnosis of severe or moderate psychotic or dementia conditions; previous history of bariatric surgery; have an allergy or intolerance to any component of food supplement formulas; be vegan or vegetarian; have any dietary restrictions regarding the consumption of whey protein; previously using some type of food supplement; be participating in another research protocol involving dietary supplementation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-10rmpmtn	Effects of four non-invasive Neuromodulation methods on Sexual Diseases : randomized clinical trial	Recruiting	Intervention	2024-02-12	<NULL>	<NULL>	6782	"Analysis of the neurophysiological and biomechanical effects of four methods of
non-invasive Neuromodulation in Sexual Diseases: randomized clinical trial"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-12-20	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-10rmpmtn	<NULL>	women aged between 20 and 45 years; who report a persistent or recurrent complaint for at least six months of at least one of the criteria of the Diagnostic and Statistical Manual of Mental Disorders (Appendix C), 5th edition of the American Psychiatric Association (2014), namely: 1) significant pain during intercourse or penetration attempts; 2) significant fear or anxiety about pain in anticipation of, during, or because of vaginal penetration; 3) stiffness or significant tightening of the pelvic floor muscles during attempts to penetrate the vagina, which represents significant suffering due to the presence of one of these criteria	women who are being treated for pelvic genital pain/penetration with the administration of anesthetic creams in the vulvovaginal region; urinary tract infection; history of epileptic or convulsive conditions; who use drugs to treat epilepsy; presence of metal implants, trauma or surgery in the head and/or neck region; intellectual disability; pregnancy; alcohol and hallucinogenic drug abuse in the last six months; who are undergoing cancer treatment with radiotherapy; and women who miss some day of the therapy proposed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-72sc84	Effects of frequent exercise with supervised weight done in hospitals and gyms on Muscle Strength, weight of muscles, bones, organs and body fluids and control of glucose, triglyceride and cholesterol values in women with type 2 Diabetes with muscle weight loss after to stop menstruating	Recruiting	Intervention	2020-07-06	<NULL>	<NULL>	3975	Effects of the regular performance of Supervised Resistance Training performed in a hospital and gym environment on Muscle Strength, Lean Mass and Metabolic Control in Type 2 Sarcopenic Diabetic women in the post Menopause period	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-06	Faculdade de Ciências Médicas de Pernambuco	PPGCS/UPE - Programa de Pós-Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-72sc84	<NULL>	Female patients, in the postmenopausal period, diagnosed with type 2 diabetes mellitus, with variations in the levels of glycosylated hemoglobin and are classified as being sedentary or irregularly active according to the International Physical Activity Questionnaire (IPAQ).	Past coronary or cerebrovascular event; carriers of chronic kidney disease with an estimated glomerular filtration rate less than or equal to 30 ml / min; orthopedic limitation for physical exercise; proliferative diabetic retinopathy; disabling diabetic neuropathy; NYHA class III or IV heart failure; established liver disease (Child B or C); decompensated thyroid disease; malignant neoplasm, except for basal cell carcinoma; in coronary, carotid or peripheral arterial revascularization schedule; documented myocardial ischemia; classified as active or very active by the International Physical Activity Questionnaire (IPAQ); participation in any training program using weights in the last 6 months; and with adherence to the systematic resistance training protocol below 80%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-7x65zj	Effects of full body Light Therapy on the muscular performance of Rugby athletes: randomized, double-blind, crossover and placebo-controlled clinical trial	Suspended	Intervention	2020-03-19	<NULL>	<NULL>	3630	Effects of full-body Photobiomodulation on muscle performance in Rugby athletes: randomized, double-blind, crossover and placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-17	Universidade Federal de São Carlos	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7x65zj	<NULL>	Healthy volunteers; male gender, non-smokers, age between 18 and 30 years, body mass index (BMI) between 18 and 30 kg / m2; volunteers must be rugby athletes for at least 1 year	Rugby athletes who have orthopedic lesions in the lower limbs previously (2 months) or during the development of the study; athletes making regular use of pharmacological agents and / or ergogenic supplements; athletes who regularly use alcohol and / or tobacco; athletes with cutaneous lesions (open wounds) on the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-9y8kjq	Effects of Functional and Traditional Training on indicators of physical fitness, quality of life and cardiovascular health in the elderly	Recruitment completed	Intervention	2019-01-03	<NULL>	<NULL>	2421	Functional Training versus Traditional Strength Training: Effects on indicators of physical fitness, quality of life and cardiovascular health in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9y8kjq	<NULL>	Be physically independent; be 60 years or older; do not present dysfunctions that restrict the practice of physical exercises; not to use hormone therapy medications, lipid-lowering agents, hypoglycemic agents and anti-inflammatories; not be involved in regular physical activity / exercise programs (two or more times / week) for at least six months prior to the start of the study	To present resting blood pressure above 160/100 mmHg; history of anemia, cerebrovascular disease, acute myocardial infarction, orthopedic disorders that impede joint movement; deep venous thrombosis and cognitive dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-3yn9nz	Effects of functional electrical stimulation of the thigh in patients undergoing cardiac surgery	Not yet recruiting	Intervention	2018-01-15	<NULL>	<NULL>	4275	Effects of Functional Electrical Stimulation of quadriceps in patients undergoing coronary artery bypass grafting and valve replacement	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade de Santa Cruz do Sul	Universidade de Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3yn9nz	<NULL>	Patients in the postoperative period of valve replacement surgery or myocardial revascularization; Age range between 30 and 80 years; Patients of both sexes; Patients stable from the hemodynamic and neurological points of view; No elevated pulmonary vascular resistance; Signature of the Term of Free and Informed Consent (TCLE) by the legal guardian.	Present peripheral nervous injury; Present heart pacemaker; Present quadriceps area with altered sensitivity; Refractoriness to electrical stimulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-9g67ytj	Effects of Functional Exercise applied Online or in Person on pain and function in patients with Fibromyalgia	Recruiting	Intervention	2025-02-21	<NULL>	<NULL>	7777	Effects of Functional Exercise via Telerehabilitation vs. In-person training on pain and functionality in patients with Fibromyalgia: a pragmatic clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9g67ytj	<NULL>	Patients diagnosed with fibromyalgia; of both sexe; aged between 18 and 60 years old; who are physically independent will be included in the study	Patients who have musculoskeletal and cardiovascular disorders that prevent them from performing physical tests and training configurations; with a diagnosis of other diseases that interfere with modulation of pain levels; who have undergone surgical procedures, physical exercise and/or physiotherapy treatment in a systematic manner in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-44jwy4	Effects of Functional Food Consumption on the Clinical and Nutritional Status of Hemodialysis Patients	Recruitment completed	Intervention	2018-02-07	<NULL>	<NULL>	1640	Effects of Green Banana and Inulin Resistant Starch Consumption on Clinical and Nutritional Status of Hemodialysis Patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-10	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-44jwy4	<NULL>	age greater than 18 years; hemodialysis time greater than 6 months, being at the time of study by AVF and with adequacy of the dose indicated by Kt / V greater than 1.2.	diagnosis of intestinal diseases; use of laxative medicine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-3xf7v9k	Effects of functional training and dual task in elderly women with and without chronic low back pain	Not yet recruiting	Intervention	2023-05-16	<NULL>	<NULL>	6082	The effects of Functional Training in asymptomatic elderly women with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3xf7v9k	<NULL>	Will be included in the research, women with a clinical diagnosis of nonspecific chronic low back pain, between 60 and 79 years old, with a complaint of low back pain for more than 3 months, a pain level greater than 3 on the numerical pain scale of 11 points and women in the same age group without low back pain and/or other type of chronic pain. Asymptomatic elderly women cannot have chronic low back pain and no episodes of pain in the last three months. Volunteers will also need to have a body mass index (BMI) &lt;30 kg/m2, not have undergone spinal surgery; not exercising regularly; not doing physical therapy or other pain treatment; not to use analgesic, anti-inflammatory, opioid or immunosuppressive medication	Exclusion criteria will be missing one of the assessments, more than 20% of the intervention or presenting any motor impairment (paraplegia, paraparesis, monoplegia, monoparesis, hemiplegia, hemiparesis), psychiatric (schizophrenia, epilepsy, severe depression) or cognitive (moderate mental retardation , severe and/or profound), auditory, visual or communication disorders that make it impossible to carry out the protocol. If there is any suspicion of a disability, the volunteer will be referred for evaluation by a general practitioner and, if confirmed, the participant will be referred to the physiotherapy, speech therapy and/or psychology departments at UFS for proper follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-7ncyyw	Effects of functional training on blood and salivary components and blood pressure of older women	Recruitment completed	Intervention	2020-03-05	<NULL>	<NULL>	3561	Effects of functional training on biochemical and hemodynamic aspects in older women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Faculdade de Medicina - UFU	Faculdade de Educação Física - UFU	https://ensaiosclinicos.gov.br/rg/RBR-7ncyyw	<NULL>	Belonging to females; Be between 60 and 80 years old; Not to be a smoker; Not practice physical exercise regularly and systematically for at least three months; Have a BMI below 32 kg / m²; Not present musculoskeletal problems or cardiovascular complications that prevent the practice of systematic physical exercises; Submit a medical assessment involving a clinical history and medical certificate.	Belonging to males; Be less than 60 or more than 80 years old; Be a smoker; Be exercising regularly and systematically; Have a BMI equal to or above 32 kg / m²; Have musculoskeletal problems that prevent the practice of physical exercises; Have a history of stroke or acute myocardial infarction; Not present medical evaluation and certificate for the practice of physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-2ngnynv	Effects of Functional Training on body and mind on the health of older people after the pandemic	Recruitment completed	Intervention	2024-10-18	<NULL>	<NULL>	7441	Impact of Functional Training on the physical and mental health of independent older people in the post-pandemic scenario	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2ngnynv	<NULL>	Be female. Age between 60 and 80. Not having participated in a systematic physical training program in the last six months. Not having had menstrual bleeding in the last twelve months. Not having musculoskeletal or cardiovascular contraindications to the practice of high-intensity physical training	Practicing physical exercises other than those proposed by the researchers during the study period. Presenting symptoms that make it impossible to practice the exercises prescribed in the study. Use of anti-inflammatory drugs during the period of the evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-557kt34	Effects of Functional Training on Cardiopulmonary  Capacity, Muscle Strength, Mobility, Balance and Quality of Life in patients with Chronic Obstructive Pulmonary Disease	Terminated	Intervention	2025-02-08	<NULL>	<NULL>	7727	Effects of Functional Training on Cardiopulmonary Capacity, Muscle Strength and Endurance, Mobility and Balance of patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-04	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-557kt34	<NULL>	Patients aged 40 years or older, both gender; with clinical and functional diagnosis of Chronic Obstructive Pulmonary Disease regardless of time and degree of obstruction; able to walk without the use of gait aids	Patients with a self-reported history of unstable angina and/or acute myocardial infarction for less than three months; neurological and musculoskeletal diseases that prevented the performance of the tests and the functional training protocol;  patients whose obstruction was not confirmed through the pulmonary function test; inability to perform or complete the proposed tests or not complete the entire functional training protocol; absence for more than two sessions (consecutive or not)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-2d56bt	Effects of Functional Training on the immune system and inflammatory responses, body composition and functionality in Overweight elderly women	Not yet recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3590	Effects of Functional Training on immunological and inflammatory parameters, body composition and functionality in Overweight elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-30	José Carlos Aragão Santos	José Carlos Aragão Santos	https://ensaiosclinicos.gov.br/rg/RBR-2d56bt	<NULL>	Being female. At least 60 years of age. Be physically independent. Have a body mass index greater than 24.9 kg / m². Obtain a minimum score of 14 on the mini mental state exam (FOLSTEIN et al., 1975). Absence of musculoskeletal or cardiovascular disorders that make it impossible to perform high-intensity physical exercises. Be at least six months without performing any regular physical activity.	Attendance rate below 80%. Miss any of the evaluation sessions. Begin some type of regular exercise practice in addition to that proposed in this work during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-996f8qn	Effects of Galvanic Vestibular Stimulation on posture and movement in patients with Parkinson&apos;s Disease: randomized clinical trial	Recruiting	Intervention	2025-02-10	<NULL>	<NULL>	7731	Effects of Galvanic Vestibular Stimulation on motor control in patients with Parkinson&apos;s Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-26	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-996f8qn	<NULL>	Patients between 50 and 75 years of age; female or male; with a diagnosis of Parkinson&apos;s Disease - idiopathic PD in stages 2-3 of the modified Hoehn &amp; Yahr Disability Scale (HY); undergoing regular monitoring at the Movement Disorder Outpatient Clinic; able to walk independently	Unable to remain independently in the standing position; severe visual impairment or not compensated with the use of corrective lenses; orthopedic disorders resulting in limitation of movement; using medication that acts on the vestibular system (e.g.: cinnarizine, flunarizine, betahistine, dimenhydrinate, meclizine and gingko biloba, among others); have Deep Brain Stimulation (DBS); history of seizures, pacemaker or metal implants in the head and neck region; undergoing neurofunctional physiotherapy and not accepting to suspend this treatment during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3bq4rg	Effects of Gametherapy on Dementia and Cognitive Decline in functional and cognitive capacity and biomarkers	Recruiting	Intervention	2019-09-19	<NULL>	<NULL>	5914	Functional, cognitive, hormonal and Trofic Factors responses in Dementia and Cognitive Decline in Exercise with Virtual Reality	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-26	Universidade Federal do Rio de Janeiro	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-3bq4rg	<NULL>	Inclusion criterion, having Clinica Dementia Rating 0.5; 1 and 2, with a minimum of three years of formal study.	Exclusion criteria, previous history of severe cardiopathy will be excluded; Acute or chronic musculoskeletal injuries that preclude the performance of exercises; Visual impairment that precludes the visualization of games; severe cognitive decline; Present other mental illnesses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-8t7h259	Effects of Gamma Aminobutyric Acid associated with Physical Exercise in Sedentary women	Recruitment completed	Intervention	2023-09-25	<NULL>	<NULL>	6460	GABA Phytotherapeutic for Strength Exercise practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-18	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-8t7h259	<NULL>	Women, aged 18 years or older; Body Mass Index (BMI) equal to or greater than 25; sedentary for at least three months	Use of medications or supplements for weight loss or hypertrophy, receive nutritional guidance and start using medications that could interfere with the results of the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-53trrwk	Effects of graded exercise in pain processing in patients with knee arthrosis	Recruiting	Intervention	2023-10-01	<NULL>	<NULL>	6471	Effects of graded exercise in pain processing in patients with knee Osteoarthritis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-26	Programa de Pós-Graduação em Fisioterapia, Departamento de Fisioterapia, Universidade Federal de São Carlos	Hospital Universitário da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-53trrwk	<NULL>	40 years or older,both sexes, clinical (American College of Rheumatology) and/or radiological (K/L II, III or IV) diagnosis of knee osteoartritis, pain as a primary symptom, mean pain intensity ≥ 4 on numerical pain scale (NPS) in the 7 days before the evaluation	"Trauma or muscle damage, physiotherapy (more than once a week), regular physical activity (≥ 150 minutes per week), corticosteroid infiltration in last 30 days, history of knee surgery(s), rheumatic diseases, chronic painful syndromes, peripheral neuropathy, motor deficit, neuromuscular diseases, severe or uncontrolled cardiovascular diseases, health conditions that risk the safety of participants,
pregnancy, recent history of substance dependence, inability to understand and follow instructions, inability to move without outside assistance, and initiation of treatment programs during"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-2c4xxb	Effects of grape juice consumption improvements in functionality and cognition of individuals with Parkinson&apos;s disease who perform aquatic physiotherapy	Recruitment completed	Intervention	2019-10-31	<NULL>	<NULL>	3158	Effects of grape juice consumption on biomarkers, functionality and cognitive function of individuals with Parkinson&apos;s disease who perform aquatic physiotherapy: A randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-2c4xxb	<NULL>	The participants with diagnosis of Parkinson&apos;s disease will be included after a confirmation by qualified professional, who accept to participate in the intervention, the included participants must regularly attend Parkinson&apos;s care in the clinic of the Southern Methodist University Center.	Any complications during the application of the intervention, or any restriction regarding the consumption of the juice.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-6h8xfn	Effects of grape juice consumption on muscle damage and pain in volleyball athletes	Data analysis completed	Intervention	2020-04-07	<NULL>	<NULL>	3712	Effects of grape juice consumption on oxidative stress and muscle fatigue in volleyball athletes: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-30	Centro Universitário Metodista IPA	Centro Universitário Metodista	https://ensaiosclinicos.gov.br/rg/RBR-6h8xfn	<NULL>	Starting players; male; aged between 14 and 20 years; have daily training routines.	Injured athletes who are out of training and / or competing in the past six months, athletes using anti-inflammatory drugs, and athletes who have an aversion or allergy to the components of grape juice will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-8dtkq9	Effects of Grape Seed Flour consumption on intestinal flora and metabolic parameters of  individuals with Obesity	Not yet recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3603	Effects of Grape Seed Flour intake on intestinal microbiota and metabolic parameters in  individuals with Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Luciana Pellegrini Pisani	Yasmin Alaby Martins Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-8dtkq9	<NULL>	Male and female adults; between 20 and 59 years old; residents from Baixada Santista; with obesity, BMI between 30 and 39.9 kg/m²	Regular or continuous use of anti-inflammatory or antibiotic medications in the last 3 months; chronic alcohol intake above 30grams per day; heart disease; liver disease; kidney disease; cancer; acute gastrointestinal problems, including diagnosed lactose intolerance; pregnancy or lactation; and menopause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-6hxvph7	Effects of green tea kombucha on health and physical performance	Not yet recruiting	Intervention	2025-07-01	<NULL>	<NULL>	8093	Green tea kombucha with grape peel phenolic extract: sensory evaluation and the acute and chronic effects on health and physical performance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-20	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Departamento de Tecnologia de Alimentos da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-6hxvph7	<NULL>	Men and women; aged between 18 and 45 years; body mass index between 18.5 and 24.9 kg/m²; with low to moderate levels of physical activity, assessed by the International Physical Activity Questionnaire – short version (IPAQ)	Individuals with chronic diseases or disorders affecting the digestive, oral, hepatic, renal, cardiovascular, or thyroid systems; individuals with cancer; inflammatory diseases or eating disorders; those who have used anti-inflammatory drugs, corticosteroids, or antibiotics in the past three months; pregnant, breastfeeding, or menopausal women; individuals who use tobacco and/or drugs; those with alcohol consumption exceeding 21 units per week for men and 14 units per week for women; individuals undergoing nutritional counseling for muscle mass gain; those who use antioxidant nutritional supplements; individuals with present or recurrent musculoskeletal injuries; those who frequently consume Kombucha, other fermented foods, or green tea; individuals with an aversion to Kombucha	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-5fdph6	Effects of green tea on physical conditioning in young untrained	Not yet recruiting	Intervention	2016-10-17	<NULL>	<NULL>	1042	Velocity of ventilatory anaerobic threshold and heart rate variability after acute supplementation of the main componets of green tea in young untrained: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5fdph6	<NULL>	Youngs of both genders, aged between 20-35, insufficient active by International Physical Activity Questionnaire (IPAQ)	"No additional orthopedic deficiencies impairing ambulation
Diabetic individuals
Individuals with cardiopathies
Individuals with body mass index maior que 30 Kg/m2
Regular caffeine or green tea drinkers
Individuals with intolerance to caffeine or green tea"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-6b8rvt	Effects of Green Tea Supplementation after Fatty Meal in obese patients on change in blood inflammation	Not yet recruiting	Intervention	2018-10-01	<NULL>	<NULL>	2253	Effects of acute green tea supplementation, after the ingestion of a hyperlipidic diet, in obese individuals, in  oxidative stress,  inflammatory process and in the expression of miRNAs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Faculdade de Medicina de Botucatu- Unesp	Faculdade de Medicina de Botucatu- Unesp	https://ensaiosclinicos.gov.br/rg/RBR-6b8rvt	<NULL>	age greater than or equal to eighteen years and obesity (BMI greater than or equal to thirty kilograms per square meter).	Use of dietary supplements and systemic corticosteroids in the last three months, diagnosis of chronic non transmissible  diseases such as hypertension, diabetes mellitus II, dyslipidemia, thyroid disease, neoplasms, coronary artery disease, stroke, heart failure, renal or hepatic failure and allergy to food offered in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-5bq9jh3	Effects of group training in elderly women with knee osteoarthritis	Not yet recruiting	Intervention	2023-08-18	<NULL>	<NULL>	6362	Effects of group training on clinical and functional aspects in elderly women with knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5bq9jh3	<NULL>	Women; age between 60 and 80 years; diagnosis of osteoarthritis of the knee according to the criteria of the American College of Rheumatology; osteoarthritis of the medial femorotibial knee on radiography classified as grades 2 or 3 according to the Kellgren and Lawrence criteria (1957); mean knee pain score between 4.0 and 9.0 on the Numerical Pain Scale (NRS);	Body mass index greater than or equal to 30 kg/m2; cognitive deficits screened by the mini-mental state examination; being in current treatment with physiotherapy or doing regular physical exercise (more than twice a week) in the last 6 months; history of joint infiltration in the last 3 months or planning to receive infiltration in the next 6 months; history of knee or hip arthroplasty; history of knee surgery in the last 6 months or planning to undergo surgery in the next 6 months; presence of other illnesses that threaten safety or prevent participation in interventions or tests (symptomatic or severe coronary artery disease; dementia; use of walking aids; other types of arthritis such as rheumatoid arthritis); history of knee trauma in the last 30 days; inability to perform training protocol (inability to walk short distances or need assistance from another person to complete activities of daily living);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-5fqjr7	Effects of guarana on physical activity practitioners	Not yet recruiting	Intervention	2018-10-30	<NULL>	<NULL>	2306	Effects of guaraná (paullinia cupana) supplementation on the regulation of oxidative stress and on blood biomarkers after physical exercise in physical activity practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-05	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5fqjr7	<NULL>	"Age between 18 and 30 years;
Do not use medicines;
That they never answer &quot;yes&quot; to the Par-Q questionnaire;
That they accept to participate in the study without any type of remuneration, besides the aid of cost related to the trip to the university in the days of the collections."	"Initiate the use of any medication during the experimental phase of the research;
Suffer some injury that is not related to the symptoms of fatigue;
Miss one of the protocol days;
Ask to leave the survey."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-3nvq79h	Effects of Guarana on physical performance: a clinical study on anaerobic fitness	Data analysis completed	Intervention	2025-01-06	<NULL>	<NULL>	7637	Effects of Guarana (Paullinia cupana) supplementation on Heart Rate Variability and Anaerobic Fitness: a randomized, crossover, placebo-controlled, triple-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3nvq79h	<NULL>	Healthy and physically active men; age between 18 and 30 years; non-smokers; no history of cardiovascular or musculoskeletal diseases; not using any medication or ergogenic substances	Individuals who do not meet the inclusion criteria; are unable to perform the jump protocol or withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-8m8v2x	Effects of Hammock Method in incubator on pain, sleep state and heart rate of premature newborns admitted to the Neonatal Intensive Care Unit	Data analysis completed	Intervention	2018-07-06	<NULL>	<NULL>	1972	Effects of Hammock Method on pain, sleep state and physiological variables of newborns admitted to the Neonatal Intensive Care Unit	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Católica de Pelotas	Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8m8v2x	<NULL>	Patients hospitalized at the Neonatal Intensive Care Unit of a university hospital; considered  premature;  with gestational age less than 37 weeks; up to 60 days of age; clinically stable.	clinical instability; heart rate bigger then 180 beats per minute or less than 100 beats per minute; respiratory rate bigger than 60 breaths per minute or  less than 40 breaths per minute; SpO2 less than 89%; infants needing ventilatory support; presence of infectious process; use of phototherapy; neurological problems and congenital facial malformations that would not allow the application of the Pain Assessment Scale NIPS, as well as the Sleep State Assessment Scale and Adapted Vigilance of Brazelton.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-7znwrjm	Effects of Handgrip Training on blood pressure variability and cardiac autonomic modulation in hypertensive patients	Recruiting	Intervention	2023-01-03	<NULL>	<NULL>	5798	Effects of Isometric Handgrip Training on blood pressure variability and cardiac autonomic modulation in Hypertensive patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-16	Faculdade de Educação Física, Universidade Federal do Amazonas	Faculdade de Educação Física, Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-7znwrjm	<NULL>	Both sexes, over 18 years old;diagnosis of Hypertension limited to stage II; not have high cardiovascular risk; not participating in a physical exercise program for at least six months prior to the start of the study	Adherence less than 85% of training sessions; diagnosis of other cardiovascular diseases or diabetes during the course of the study; adherence to another supervised exercise program during the study; change in medication class and/or dose during the study; disease worsening (Stage III SAH, ≥180 and ≥110 mmHg, systolic and diastolic blood pressure, respectively)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-10q6wv5t	Effects of Hatha Yoga practice on respiratory strength, knowledge management, emotional health and daily physical performance of women 60+	Recruitment completed	Intervention	2026-01-09	<NULL>	<NULL>	8724	Effects of a Hatha Yoga program on respiratory function, cognition, mental health and functional performance of elderly women: randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-01	Elaine Cristina da Silva Brandão	<NULL>	<NULL>	<NULL>	Be between the ages of 60 and 85;Have no musculoskeletal impairment to practice;Have no prior history of thoracic surgery	Having been diagnosed with a recent cerebrovascular disease;Having been diagnosed with a disease of the head (head and neck cancer), eyes, or ears	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-3vz3nd	Effects of Hatha-Yoga on caregivers of children and adolescents with Cancer	Data analysis completed	Intervention	2018-04-10	<NULL>	<NULL>	1702	Effects of Hatha-Yoga intervention on caregivers of children and adolescents with Cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-29	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Hospital Infantil Nossa Senhora da Glória	https://ensaiosclinicos.gov.br/rg/RBR-3vz3nd	<NULL>	Accompanying children and adolescents admitted to HINSG as new cases of cancer; minimum attendance period of 40 weekly hours; absence of prior contact with yoga, meditation or related techniques.	"Volunteers who did not agree to participate in the study or who showed interest were very resistant to being absent from their caregivers, or even if they presented psychic limitation to answer the questions of the initial interview. Cases of hospitalization or deaths in a very short period precluding the invitation to participate in the study; hospitalizations with advanced and irreversible impairment of the patient&apos;s clinical condition, that is, in palliative care; and the cases of prior knowledge of the volunteer about the diagnosis of the assisted.
In the cases of relay of caregivers in care of the same child or adolescent only the participation of a volunteer was allowed, whose choice to participate in the study was based on the above criteria. When caretakers in relay were able to participate in the study a draw was held between them. However, hospitalizations of children or adolescents with many caregivers in relay with uncertainty of a regular return to care were excluded from the study, configuring the non-inclusion of the volunteer during the study period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-2q52rs	Effects of health education in the prevention of cervical cancer	Recruitment completed	Intervention	2015-06-05	<NULL>	<NULL>	502	Impact on education intervention in the adherence to the cervical cancer prevention	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-09-22	Universidade Federal do Triângulo Mineiro (UFTM)	Universidade Federal do Triângulo Mineiro (UFTM)	https://ensaiosclinicos.gov.br/rg/RBR-2q52rs	<NULL>	180 women; aged between 25 and 64 years; public service users of municipal health to perform Pap	Women who are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-8fvmt99	Effects of Health Self-Management Strategies on biological, psychological and social aspects of people with Rheumatological Diseases	Not yet recruiting	Intervention	2024-02-20	<NULL>	<NULL>	6795	Effects of a health self-management strategy protocol on biophychosocial aspects of individuals with rheumatological diseases: a single-blinded randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8fvmt99	<NULL>	Volunteers diagnosed with any rheumatological disease; Are not undergoing any type of physiotherapeutic treatment; Older than 18 years; Both genders	History of recent fracture (last 3 months); Have participated in any therapies in the last 3 (three) months; Inability or interruption during functional tests; Perform more than 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity per week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-36q469s	Effects of Healthy Eating on Constipation in Parkinson&apos;s Disease	Recruiting	Intervention	2024-09-21	<NULL>	<NULL>	7365	Effects of the Mediterranean Diet on Constipation in Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-05	Hospital Ophir Loyola	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-36q469s	<NULL>	Parkinson Disease patients; constipation symptoms according to the bristol scale types 1 and 2 and diagnosis of chronic constipation according to the Rome III criteria; age over 18 years old; agree to participate in data collection and sign the free and informed consent form (TCLE)	Patients diagnosed with dementia associated with Parkinsoon Disease, according to the criteria of the movement disorders society task force; history of other neurological diseases, with associated and diagnosed psychiatric illnesses; use of oral laxative medicatios, enemas and laxative suppositories during the study; use of antibiotics one month before the initial assessment; diagnosis or history of inflammatory and neoplastic gastrointestinal diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-48bhsdx	Effects of Heated Blanket on Premature babies	Recruiting	Intervention	2023-01-18	<NULL>	<NULL>	5831	Effects of Thermal Blanket in Premature newborns: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-18	escola de enfermagem Anna Nery	hospital universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-48bhsdx	<NULL>	Premature newborns below 34 weeks up to 25 weeks of Gestational Age; low and very extreme low weight; in ventilatory assistance or not; normothermic or hypothermic, with vital functions in the normal range	Newborns received from another institution, at term, post-term, malformed, asphyxia who present dysthermia of central origin, hyperthermia and hemodynamic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-7mn7yj	Effects of High Intensity Exercise Training in Patients with Chronic Obstructive Pulmonary Disease in a Pulmonary Rehabilitation Program	Data analysis completed	Intervention	2020-03-04	<NULL>	<NULL>	3566	Effects of High Intensity Exercise Training in Patients with Chronic Obstructive Pulmonary Disease in a Pulmonary Rehabilitation Program	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-09-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7mn7yj	<NULL>	with moderate to severe COPD, (post-bronchodilator FEV1&gt; 30% and predicted &lt;80%)	"Exclusion criteria were:
 indication and / or use of chronic home oxygen therapy, inability to perform physical tests, symptomatic coronary disease, musculoskeletal limitation and neurological disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-3v3dqf	Effects of High Intensity Interval Training (HIIT) on Metabolic, Inflammatory, Arterial Stiffness and Myocardial Deformation in Obese women: a Randomized Clinical Trial	Not yet recruiting	Intervention	2019-07-05	<NULL>	<NULL>	2805	Effects of High-Intensity Interval Training (HIIT) on Metabolic, Inflammatory Parameters, Arterial Stiffness and Myocardial Deformation (STRAIN) in Obese women:a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-16	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-3v3dqf	<NULL>	Be female; be between 18 and 35 years of age; present a picture of obesity (BMI: greater than or equal to 30 kg/m²); individuals with body weight stabilized for at least 12 weeks; who have not participated in weight reduction programs before; not suffering from cardiopathies, diabetes and / or hypertension and endocrine diseases; non smokers; who are not making use of medicines that can alter cardiorespiratory and neuromuscular systems; with readiness to participate in evaluations and interventions; and signing of the Informed Consent Form (TCLE).	Volunteers who present in the clinical evaluation and / or laboratory tests any pathology or other complications that may be risk factors or adhesion to the regular practice of the proposed physical activity; and any other condition that could interfere with the test and /or intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-9nd7py4	Effects of High Intensity Interval Training on Metabolism in Obesity.	Recruiting	Intervention	2022-05-02	<NULL>	<NULL>	5375	Redox State, Immunometabolism and Meta-inflammation in Obesity: Gene Expression and Responses to High-Intensity Interval Training.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade da Região de Joinville	Hospital Regional Hans Dieter Schmidt	https://ensaiosclinicos.gov.br/rg/RBR-9nd7py4	<NULL>	Both genders; being assisted by the Public Health System (SUS); age between 20 and 55 years; deliver the signed Informed Consent; do not participate in any other regular physical exercise program; do not present untreated or poorly controlled clinical disorders that could interfere with the variables of the study, such as altered levels of the TSH and free T4 hormones, even when taking medication; do not present untreated or poorly controlled clinical disorders, such as arterial hypertension, heart disease, or any other disease that could offer risk to the participant when practicing high-intensity exercises.	Any clinical complication during the intervention that influences the variables analyzed in this study or makes it impossible for the participant to continue the intervention and/or the evaluations, including orthopedic alterations or pain disorders; frequency in the HIIT program lower than 70% or absence from any evaluation performed in the study; use of appetite-suppressant medications; presence of diabetes; being menopausal, according to medical criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-7k6pfb	Effects of high intensity of exercise  in female athletes	Not yet recruiting	Intervention	2016-03-02	<NULL>	<NULL>	1421	"The peripheral muscular  oxygenation and ventilatory during dynamic exercise of high
intensity players from football: A randomized clinical trial of the effects of
respiratory muscle training in improving exercise tolerance"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-18	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7k6pfb	<NULL>	Twenty healthy volunteers; female; non-smoking; aged between 18 and 25 years; athletes	Cardiac diagnosis; renal; hepatic; pulmonary; neurological; psychiatric; hematological or metabolic disorders; that are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-6874vff	Effects of High Intensity Training in patients who underwent Angioplasty	Data analysis completed	Intervention	2023-12-13	<NULL>	<NULL>	6655	Effects of High Intensity Interval Training in patients undergoing Primary Angioplasty	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Hospital Ilha do Leite (Hapvida)	Instituto de Cardiologia o Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6874vff	<NULL>	The main inclusion criteria to participate in the present study are participants between 40 and 65 years old; who underwent myocardial revascularization through angioplasty with occlusion ≥ 50%; must have preserved ejection function with an ejection fraction ≥ 40%; no signs of moderate or severe myocardial ischemia detected by perfusion scintigraphy; do not present with angina; do not present ischemia caused by physical exercise; not participate in any type of systematic physical activity; and be classified among those irregularly active	Those patients who present the following symptoms during the study will be excluded from the study. unstable angina; decompensated systemic arterial hypertension with SBP≥180 mmHg or DBP≥110 mmHg; drop in orthostatic pressure of 20 mm Hg with symptoms, significant aortic stenosis with aortic valve area of 1.0 cm2; uncontrolled ventricular or atrial arrhythmia; sinus tachycardia ≥120 bpm; third-degree atrioventricular block without a pacemaker; active pericarditis or myocarditis; recent embolism; acute thrombophlebitis; uncontrolled diabetes mellitus; have orthopedic limitations or any physical or mental limitation that prevents the performance of physical exercises; not attending at least 85% of physical training sessions or missing an entire week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-8ndsbq	Effects of High Intensity }Training on health of younger with Obesity	Recruitment completed	Intervention	2018-02-24	<NULL>	<NULL>	1819	Effects of High Intensity Interval Training on factors associated to physical and mental health and behavioral changes in younger adults with Obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Departamento de Ciências do Movimento Humano da Universidade Federal de São Paulo	Universidade Federal de São Paulo Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-8ndsbq	<NULL>	Subjects will be included if they are young male adults 18 to 30 years old. Obese BMI 30.0 to 39.9 kg / m². Eutrophic BMI 18 to 25 kg / m² according to criteria established by the World Health Organization.	Exclusion criteria are. Positive responders for one of the questions of the physical activity readiness questionnaire (PAR-Q). Genetic, metabolic or endocrine disease – other than obesity (self-reported). Chronic alcohol consumption. Previous use of drugs which could modulate the outcomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-5g6jk5c	Effects of High Power Diode Laser Photobiomodulation on Bichat Ball Removal: a Split-Mouth Controlled Clinical Trial	Recruiting	Intervention	2023-11-02	<NULL>	<NULL>	6558	Effects of High Power Diode Laser Photobiomodulation on Removal of Buccal Fat Pads: a Split-Mouth Controlled Clinical Trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-14	Universidade Federal do Maranhão	Programa de Pós Graduação em Odontologia da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-5g6jk5c	<NULL>	aesthetic-functional need for bilateral partial surgical removal of the buccal fat pads; complaint of unilateral or bilateral nibbling on the buccal mucosa; complaint of disproportionality of the lower third of the face; good systemic health condition, therefore no comorbidities	present systemic comorbidities; smokers; pregnant or breastfeeding women; signs of any pre-operative inflammatory or infectious condition; are using any medication that interferes with the pain mechanism; history of allergies or adverse effects that prevent the use of medications that will be used in the study; present any significant facial asymmetry; have progressive hemifacial atrophy; underwent facial liposuction, lipolysis injection or bichectomy procedure prior to the research; they wish to have the surgery just for aesthetic reasons.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-23bfm3z	Effects of High-Intensity Respiratory Training on Blood Pressure and Heart Health in People with Hypertension	Recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8912	Effects of High-Intensity Inspiratory Muscle Training on Blood Pressure and Heart Rate Variability in Hypertensive Patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal do Delta do Parnaíba	<NULL>	<NULL>	<NULL>	Residents of the city of Parnaíba, Piauí; both sexes; clinical diagnosis of arterial hypertension; age between 50 and 70 years; signed Informed Consent Form; stable medication treatment for more than 2 months; maintenance of medication stability throughout the study	Poor adherence to the protocol; medication changes during the intervention; withdrawal of consent; pregnant women; breastfeeding women; active smokers; systolic blood pressure below 90 millimeters of mercury or above 160 millimeters of mercury; diastolic blood pressure above 100 millimeters of mercury; current or recent history of deep vein thrombosis; severe dyspnea; diabetes mellitus; neurological impairments; cognitive impairments; other cardiovascular diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-7n8y9ky	Effects of HIIT and Conventional Resistance Training on Maximal Strength and Muscle Hypertrophy	Data analysis completed	Intervention	2021-03-09	<NULL>	<NULL>	4570	Comparison effects of High Intensity Interval Training and Resistance Training on Maximal Strength and Muscle Hypertrophy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Centro Universitário da Serra Gaúcha	Centro Universitário da Serra Gaúcha	https://ensaiosclinicos.gov.br/rg/RBR-7n8y9ky	<NULL>	Healthy men; age between 18 and 35 years; Minimum experience of six months in strength training or running on a treadmill	Men with lower limb injuries; diagnosis of heart disease; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-4c575v	Effects of hip muscle strengthening on body balance in patients with chronic ankle instability	Recruitment completed	Intervention	2018-10-25	<NULL>	<NULL>	2299	Effects of hip muscle strengthening on dynamic postural control of individuals with Chronic Ankle Instability	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4c575v	<NULL>	Be between 18 and 35 years old; Present history of at least one unilateral ankle sprain injury for at least 6 months; Have ankle instability; Present scores less than or equal to 25 points in CAIT; Do not have joint blockage of the movement by fixation of surgery, ankylosis or arthrofibrosis in the ankle; Have not had surgery in the lower limbs in the last 6 months; Do not be a gestational woman.	Absence of 2 consecutive days of training; Absence in at least one of the evaluations; To present pain or worsening of the clinical picture with the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-6phs67	Effects of hippotherapy on the elderly	Recruiting	Observational	2020-07-30	<NULL>	<NULL>	4068	Effects of hippotherapy on the cardiovascular, immune, stomatognathic system and postural balance in elderly practitioners: longitudinal study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-10	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo FORP/USP	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo FORP/USP	https://ensaiosclinicos.gov.br/rg/RBR-6phs67	<NULL>	Individuals of both genders and age between 60 and 79 years, without compromising gait and who are beginning the practice of hippotherapy with the project.	Epilepsy, hypertension (uncontrolled), acute heart disease, spinal instability, severe cervical spine disorder, shoulder or hip dislocation, scoliosis evolving by 30 degrees or more, decubitus ulcers in the pelvic region or in the lower limbs, uncontrollable fear who did not complete the expected number of sessions and / or had more than two consecutive absences during the sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-6r3q4zn	Effects of home Exercise Technology for the elderly	Not yet recruiting	Intervention	2023-07-04	<NULL>	<NULL>	6199	Development and Evaluation of Home Exercise Technology for the elderly: Heeh Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Universidade de Brasília	Secretaria de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-6r3q4zn	<NULL>	Both sexes; age between 60 and 80 years; be registered and monitored at the Ambulatory; own or have relatives in the same household who have a smartphone that supports the application with internet access; be available to attend the monthly consultations carried out throughout the study; being independent in activities of daily living, through the Barthel index; non-practitioners of physical activity or insufficient physical activity, assessed using the International physical activity questionnaire (IPAQ), an instrument that assesses the level of physical activity	Age greater than 80 years; chronic complications of DM (neuropathy; nephropathy, retinopathy, limb amputation and diabetic foot); participate in another clinical trial, research study, or exercise program where they perform similar balance and strength activities; having mobility limitations or using walking devices; diagnosis of progressive neurological disease or other acute or unstable medical condition that precludes performing the exercises; make use of medications that interfere with balance; failing to perform any evaluation proposed in the study protocol; presenting cognitive impairments assessed through the Mini Mental State Examination (MMSE) - the cutoff scores used for exclusion will be: 17 for illiterates; 22 for seniors with between 1 and 4 years of schooling; 24 for those with between 5 and 8 years of schooling and 26 for those with 9 or more years of schooling; and those with mobility deficits – Timed Up-and-Go (TUG) over 20 seconds, a timed test that assesses walking speed, balance and risk of falling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-8xrzjs	Effects of home guidance provided by parents on the functionality of infants at biological risk	Recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4836	Tele-care protocol performed by parents involving specific task- environment- participation (STEP protocol) for infants at risk for cerebral palsy- randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8xrzjs	<NULL>	Infants aged 3 to 12 months of corrected age will be included; of both sexes; with moderate to high risk for developmental delay. Moderate to high risk infants will be considered to be those who meet at least one of the following criteria, being they born before 33 weeks of gestational age; weight below the 10th percentile according to gestational age and sex; Apgar score from 0 to 3 for more than 5 minutes; neurological manifestations in the neonate such as seizures, coma or hypotonia; need for cardiorespiratory resuscitation or use of oxygen therapy; prolonged hospital stay in the Intensive Care Unit; presence of abnormal General movements.	Infants over 12 months of age will not be included in the study; no risk of developmental delay; who have diagnosed primary diseases and congenital diseases; autism; Down&apos;s syndrome; muscular dystrophies; heart diseases; renal changes; bone deformities; confirmed blindness or deafness; infants with severe respiratory diseases; epilepsy or frequent seizures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-34w59y	Effects of hydrotherapy in preterm infants admitted to the neonatal intensive care unit	Recruitment completed	Intervention	2018-11-01	<NULL>	<NULL>	2309	Effects of Aquatic Physical Therapy in prematures of the neonatal intensive therapy unit	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-06	Centro Universitário Franciscano	Daniela Cristina Rambo	https://ensaiosclinicos.gov.br/rg/RBR-34w59y	<NULL>	Premature infants hospitalized in the period from November 2017 to May 2018; who are stable; in ambient air or oxygen therapy via nasal glasses; minimum stay in the Neonatal Intensive Care Unit for 7 days; premature infants in orogastric feeding and signed Consent Form; by parents and / or guardians agreeing that the newborn participates in the study.	Premature infants in invasive mechanical ventilation or non-invasive mechanical ventilation; in the pre or postoperative period; with skin lesions; with neurological diseases; with sedatives; without the prescription of physical therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9rzr3r	Effects of hypertonic saline and Dornase alfa in children with cystic fibrosis	Recruitment completed	Intervention	2019-10-16	<NULL>	<NULL>	3096	Immediate effects of hypertonic saline and Dornase alfa on respiratory mechanics in children with cystic fibrosis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Renata Maba Gonçalves	UDESC	https://ensaiosclinicos.gov.br/rg/RBR-9rzr3r	<NULL>	This study included children and adolescents with CF between 6 to 14 years of age, under regular follow-up at the CF outpatient clinic in the Joana de Gusmão Children&apos;s Hospital (HIJG) in Florianópolis/SC-Brazil. The diagnosis was confirmed by two altered sweat tests (chlorine greater than 60mEqs/l) and confirmed genetic alterations. All participants were clinically stable at the time of data collection, according to the application of specific clinical scores. To assure clinical stability and inclusion of the participants, the Cystic Fibrosis Clinical Score (CFCS) [18] and the Cystic Fibrosis Foundation Score (CFFS) [19] for pulmonary exacerbation were applied.	Individuals who exhibited infection or upper airway alterations (coryza, sneezing, obstruction of nose, rhinitis and epistaxis) and who were unable to perform any of the study procedures were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-8jp3db	Effects of Hypopressive Abdominal Gymnastics on the respiratory and nervous systems	Not yet recruiting	Intervention	2020-07-09	<NULL>	<NULL>	4451	Effects of Hypopressive Abdominal Gymnastics on lung function, respiratory muscle strength and autonomic nervous system	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-03	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8jp3db	<NULL>	women; nulliparous; healthy; aged 20-30 years,UFTM students; residents in Uberaba; BMI between 18.5 and 24.9.	history of abdominal and / or pelvic surgery;pregnancy or suspected pregnancy,high blood pressure, neurological diseases, diabetes mellitus, smoking, respiratory diseases;heart disease; use of intrauterine device (IUD) for less than 90 days; BMI equal to or greater than 25	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-6wzmwx	Effects of Ice and Electrical Current on patients with partial loss of movement and muscle stiffness	Recruiting	Intervention	2018-07-20	<NULL>	<NULL>	2038	Effects of Chryotherapy and Neuromuscular Electrical Stimulation in Spastic Hemiparetic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-12	SOBEU - Associação Barramansense de Ensino	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-6wzmwx	<NULL>	Patients in the chronic phase of stroke (at least 3 months after injury); have a maximum grade 3 and minimal degree +1 spasticity according to the Modified Ashworth scale; medical indication for physical therapy; adequate understanding and communications competencies; agree to be part of the study in accordance with the authorization of free and informed consent	Patients younger than 45 and older than 90 years who present with Raynaud&apos;s disease; thromboangiitis obliterans; cryoglobulinemia; cold urticaria; uncontrolled hypertension; sensory deficiency; cold aversion; spasticity grade 4 according to the modified Ashworth scale; aphasia or Wernick&apos;s dysphasia; trophic changes at the site of electrical stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-8z285wq	Effects of Immersive and Non- Immersive Virtual Reality Games on Anxiety and Cognition in Parkinson&apos;s Disease	Terminated	Intervention	2024-01-17	<NULL>	<NULL>	6737	Usability, applicability, and therapeutic potential of Different Virtual Reality Systems in patients with Neurological, Rheumatological, and Orthopedic Injuries	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Faculdade de Ceilândia - Universidade de Brasília-UnB	Faculdade de Ceilândia - Universidade de Brasília-UnB	https://ensaiosclinicos.gov.br/rg/RBR-8z285wq	<NULL>	The inclusion criteria were completed elementary education; a minimum score of 24 on the mini mental state examination;  a score below 7 on the Geriatric Depression Scale; a score between 1 and 3 on the Hoehn and Yahr Scale (mild/moderate); absence of auditory or visual deficits that would impair participation in the virtual reality training	The exclusion criteria were any clinical condition that would compromise the intervention; previous experience with gaming consoles and/or attending another specialized rehabilitation program during the training; history of motion sickness; dizziness; seizures; epilepsy; active nausea	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-467ksmb	Effects of Inclusion of Cannabidiol in the Usual Treatment of Obsessive Compulsive Disorder	Recruiting	Intervention	2023-03-29	<NULL>	<NULL>	5968	Clinical effects of the addition of cannabidiol to the usual treatment of patients with diagnosis of Obsessive Compulsive Disorder	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2021-01-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-467ksmb	<NULL>	Patients of both sexes; aged between 18 and 65 years; diagnosed with obsessive-compulsive disorder; undergoing outpatient pharmacological treatment with selective serotonin reuptake inhibitors or clomipramine; with current symptoms of obsessions, compulsions or both; with severity assessed by the  scale Y-BOCS (Yale-Brown Obsessive-Compulsive Scale) (score greater than or equal to 20 out of a total of 40 possible points).	Age under 18 and over 65 years; presence of relevant medical condition (cardiovascular diseases, severe arterial hypertension, renal failure, liver disease, hypothyroidism, hyponatremia, hypovitaminosis B12, previous intracranial hypertension, epilepsy, pregnancy, breastfeeding); history of neurological disease (including severe traumatic brain injury and excluding headache); previous use of cannabis in the last month or history of dependence on any other psychoactive substance; previous history of allergy or idiosyncratic reactions to cannabis sativa derivatives; psychotic symptoms; suicidal ideation; personality disorder or diagnosis of substance use disorder according to The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria. Patients with changes in their pharmacological regimen in the last 30 days will not be able to participate in the study. Patients using medications that modulate the glutamatergic system (topiramate, lamotrigine, memantine) and benzodiazepines will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-7nbvjkh	Effects of Individualized Education on Abdominal Dialysis patients	Not yet recruiting	Intervention	2023-04-17	<NULL>	<NULL>	6014	Impact of an Individualized Education tailored for the learning style on Peritoneal Dialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Pontificia Universidade Católica do Paraná	Baxter Healthcare	https://ensaiosclinicos.gov.br/rg/RBR-7nbvjkh	<NULL>	Age higher than 18 years old; chronic peritoneal dialysis for at least 3 months; peritoneal dialysis should be automated peritoneal dialysis; sign the informed consent	Not willing to participate in the study or don&apos;t sign the informed consent; Illiterate; blindness; be on assited peritoneal dialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-6dcn292	Effects of infrared and red light therapy on leg pain in patients with mild to moderate Lipedema	Recruitment completed	Intervention	2025-06-03	<NULL>	<NULL>	8034	Effects of Phototherapy on lower limb pain in individuals with mild to moderate Lipedema	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Hospital da Bahia S/A - Assistência Médica e Hospitalar	Clínica Vascular Takayanagi	https://ensaiosclinicos.gov.br/rg/RBR-6dcn292	<NULL>	Female patients; patients with lipedema classified as mild to moderate; presence of pain in adipose tissue in the extremities; age between 18 and 70 years; patients able to understand and sign the informed consent form prior to undergoing photobiomodulation	Male patients; patients who do not sign the informed consent form; patients without pain in the extremities secondary to lipedema; patients using analgesics or anti-inflammatory drugs; pregnant patients; patients with infection or malignant lesions at the application site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-7q4sdy	Effects of Infrared and water exercise in patients with fibromyalgia	Data analysis completed	Intervention	2018-10-24	<NULL>	<NULL>	2297	Effects of an infrared emitting ceramic material and hydrokinesiotherapy in patients with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-24	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7q4sdy	<NULL>	Fibromyalgia Diagnostics; Female patients with FM (ages from 30 to 69) were selected from the Physiotherapy Clinic of the University of Southern Santa Catarina (UNISUL), Brazil.	Presence of active or previous neoplastic conditions, infection or making use of oral or local corticosteroids or anti-cytokine therapy that could influence cytokines serum levels. All of the participants were advised not to do any other regular physical activity outside the exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-4x2hh8b	Effects of infusion of yerba mate (Ilex paraguariensis) in vascular function	Recruitment completed	Intervention	2023-05-16	<NULL>	<NULL>	6081	Effects of Infusion of Yerba Mate (Ilex paraguariensis) isolated or associated with Physical Exercise in Vascular Function	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4x2hh8b	<NULL>	Adults of both sexes aged between 18 and 40 years old	Smokers; individuals with cardiometabolic diseases; use of medications and supplements; with the presence of an injury in the arm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-2q2vt5	Effects of inspiratory muscle training in patients with asthma	Recruiting	Intervention	2015-05-14	<NULL>	<NULL>	472	Effects of inspiratory muscle training in patients with asthma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Departamento de Fisioterapia	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2q2vt5	<NULL>	Asthmatic adults: confirmed diagnosis of asthma, based on the criteria of the Global Initiative for Asthma, 2012; controlled asthma; aged between 18 and 60 years; absence of prior lung disease cystic fibrosis kind, bronchiectasis, tuberculosis and pneumonia. Healthy adults: Age between 18 and 60 years; absence of prior asthma-like lung disease, cystic fibrosis, bronchiectasis, tuberculosis and pneumonia; pulmonary function and respiratory muscle strength of normal.	Appearance of some lung during the training period; inability to perform the protocol established; solicitaçãoo to exit the study;  accession training protocol smaller than 80%; overweight.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-10nyzcqc	Effects of Inspiratory Muscle Training on Breathlesness, Exercise Capacity and Postural Control in Patients with COPD.	Recruitment completed	Intervention	2021-04-08	<NULL>	<NULL>	4610	Effects of Inspiratory Muscle Training on Dyspnea, Exercise Capacity and Postural Control in Patients with COPD.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-03	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-10nyzcqc	<NULL>	Age&gt; 40 years; Diagnosis of COPD according to the document GOLD (2016); Absence of exacerbations in the last 30 days; Presence of inspiratory muscle weakness (PImax &lt;70cmH2O or &lt;70% of predicted).	Diagnosis of psychiatric or cognitive diseases that compromise the understanding of the study&apos;s guidelines; Progressive neurological disease; Neuromuscular disease; Vestibular disorders; Orthopedic changes that compromise the results of field and range tests; Presence of other comorbidities that, at the researcher&apos;s discretion, may interfere with the results of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:27
RBR-5fsg97	Effects of integrative therapies in health, quality of life and wellness of breast cancer women and prostate cancer men	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1997	Effects of the Brazilian integrative wellness protocol for cancer care on quality of life, wellness, and biopsicosocial factors of breast cancer women and prostate cancer men	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-11	CREMIC - Centro Estadual de Referência em Medicina Integrativa e Complementar	CREMIC - Centro Estadual de Referência em Medicina Integrativa e Complementar	https://ensaiosclinicos.gov.br/rg/RBR-5fsg97	<NULL>	Breast cancer women; prostatic cancer men; adults; in any cancer and treatment stage.	Open lesions or  wounds; recent surgeries (less than thirty days); severe immunodeficiency ( neuthrophil count less than 500 cells per / ml).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-2nzf7q	Effects of intense cycling and/or strength training on health-related blood parameters in type 1 diabetes mellitus patients	Recruiting	Intervention	2016-10-20	<NULL>	<NULL>	1050	Effects of high-intensity interval training and/or strength training on inflammatory, oxidative stress and glycaemic metabolism in type 1 diabetes mellitus patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-26	Universidade Federal do Rio Grande do Sul	Instituto da Criança com Diabetes	https://ensaiosclinicos.gov.br/rg/RBR-2nzf7q	<NULL>	Patients with type 1 diabetes mellitus(diagnosis for over five year); physically inactive (less than 150 min weekly systematic exercise in the previous three months); with glycated haemoglobin less than 10%; age between 18-40 years.	Smoking patients; they with significant loss of renal function (creatinine &gt; 1.3 mg/dL), liver failure, musculoskeletal disorders; hypertension; heart diseases; patients with retinopathy and/or recent infections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-3zyhygn	Effects of intense training on memory and attention in people with High Blood Pressure and cognitive difficulties	Not yet recruiting	Intervention	2026-03-18	<NULL>	<NULL>	8995	Effect of high-intensity interval training on cognitive performance in hypertensive individuals with cognitive impairment: a blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-14	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Individuals of both sexes; age between forty-five and sixty-four years; diagnosis of early-onset systemic arterial hypertension before fifty-five years of age; undergoing treatment for systemic arterial hypertension; presence of mild to moderate cognitive impairment assessed by the Montreal Cognitive Assessment	Individuals with Systemic arterial hypertension stage two, defined by systolic blood pressure equal to or higher than one hundred and sixty millimeters of mercury and or diastolic blood pressure equal to or higher than one hundred millimeters of mercury; presence of severe cognitive impairment or diagnosis of dementia; speech impairment that limits or prevents communication; diagnosis of severe untreated mental disorder; history of severe cardiac diseases; abnormal twelve-lead electrocardiogram at rest or during physical exertion; contraindication to physical exercise indicated by a cardiologist; presence of secondary hypertension; evidence of target organ dysfunction, including kidneys and retina; grade two obesity; presence of severe cardiometabolic diseases; current participation in a structured physical training program; female participants with premature menopause, before forty years of age, or induced menopause	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-5rb2ps	Effects of intensities of exercise combined on type 2 diabetic women in menopause	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	4228	Effects of exercise intensity on metabolic, respiratory and cardiovascular parameters in type 2 diabetic women - a clinical randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal de Lavras	Financiamento Próprio	https://ensaiosclinicos.gov.br/rg/RBR-5rb2ps	<NULL>	Being a carrier of DM2; being in amenorrhea for at least 12 consecutive months; be able to exercise by Par-Q; being sedentary or not engaging in regular physical activity (not practicing a minimum of 150 minutes of physical exercise per week according to WHO criteria).	Use of hormone replacement therapy; smoking; presence of coronary artery disease or debilitating diseases; hysterectomized women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4qyc94	Effects of intensity exercises in functional capacity in older woman	Recruitment completed	Intervention	2016-12-27	<NULL>	<NULL>	1118	Effect of High Intensity Interval Training protocol in functional capacity in older woman of Rio Pomba city - MG: A randomized controlled triall	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Instituto Federal do Sudeste de Minas	Secretaria de Saúde da cidade de Rio Pomba	https://ensaiosclinicos.gov.br/rg/RBR-4qyc94	<NULL>	Age greater than 65 years; group of practitioners Exercise and Wellness for more than three months; agreement to participate in the study and signed the free and informed consent	HIV patients; poorly controlled hypertension (SBP: 165 mmHg and / or DBP: 100 mmHg); decompensated diabetes (random blood glucose: 200 mg / dL); severe heart disease; severe neurological disorders; neuromuscular and musculoskeletal disorders incapacitating to perform the experimental protocol; neoplasms; patient unable to understand the objectives of the study and / or informed consent. There will also be excluded from the protocol those who submit, twice in succession or three times alternating, pressure values and / or glucose, above the pre-set values (criteria not included) during the training protocol and those missing protocol more than three times alternating or consecutive.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-35kjvg	Effects of intensive nutritional counseling on nutritional status and quality of life of patients with head and neck cancer  undergoing radiation therapy	Not yet recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1210	Effects of intensive nutritional counseling on nutritional status and quality of life of patients with head and neck cancer  undergoing radiation therapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-18	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-35kjvg	<NULL>	Patients with head and neck cancer (oral cavity, oropharynx, hypopharynx and larynx); both sexes; aged 18 years and over, submitted to radiotherapy as a first-choice treatment or as adjuvant treatment (post-surgical).	Patients using parenteral nutrition; without cognitive ability to understand the concepts of the questionnaires; in palliative radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2fczbt2	Effects of Intensive Rehabilitation of upper limbs associated with Non-Invasive Neuromodulation in children with cerebral palsy	Recruiting	Intervention	2026-01-15	<NULL>	<NULL>	8760	Effects of Pediatric Constraint-Induced Movement Therapy associated with Transcranial Direct Current Stimulation in children with Cerebral Palsy: randomized, triple-blind, controlled study, with implementation and cost-effectiveness analysis	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-28	Universidade Cidade de São Paulo (UNICID)	<NULL>	<NULL>	<NULL>	Patients diagnosed with Cerebral Palsy – CP of the spastic hemiparesis type; aged between 7 and 16 years; cognitively able to respond to commands requested by the therapist; able to attend the Association for Assistance to Disabled Children – AACD Ibirapuera for 3 weeks, 3 hours/day, 5 days/week; be accompanied throughout the entire protocol by the same caregiver, who participates in the child’s/adolescent’s routine; from a motor standpoint, the patient must be able to perform active movement of the Affected Upper Limb (AUL) with at least 45 degrees of shoulder flexion and abduction, 20 degrees of elbow extension, 10 degrees of wrist extension, and movement of three fingers, including the thumb (grades 2 and 3 of the Active Range of Motion Scale of CIMT); patients classified by the Manual Ability Classification System – MACS at levels I or II; no history of seizure in the last 12 months (patients who previously presented seizures, even if before the established 12 months, will be carefully evaluated by the medical team responsible for performing the Electroencephalogram – EEG for clearance to carry out the protocol); it will also be necessary to sign and complete the Safety Questionnaire prior to the HotSpot mapping procedure by Transcranial Magnetic Stimulation – TMS, to verify that the patient does not have any contraindication to the application of the technique; both gender	Patients who present musculoskeletal deformities that reduce the range of motion of the affected upper limb – AUL in each of the joints (shoulder, elbow, wrist) by more than 10 degrees; who present extensive encephalic lesions or untreated hydrocephalus; who have received botulinum toxin injections in AUL muscles within the last 6 months or have undergone corrective orthopedic surgery of the AUL during this same period; who have metallic implants in the cranial vault region or who have shunt valves with a metallic component	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-3p7wsr	Effects of interactive games on brain activation and quality of life of individuals with spinal cord injury	Recruiting	Intervention	2018-05-24	<NULL>	<NULL>	1846	Effects of Virtual Reality on brain activation and quality of life of individuals with Spinal Cord Injury	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-30	Universidade de Franca	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-3p7wsr	<NULL>	participants of both sexes; age between twenty and fifty years; clinical diagnosis of complete and / or incomplete spinal cord injury; at least one year of injury; be able to tolerate static posture for at least five minutes without minimal assistance; agree to discontinue the traditional treatment of physical therapy during the period of data collection.	Participants with significant orthopedic injuries that could limit seated posture, such as severe contractures or cutaneous lesions in the lower limbs; presenting spinal stabilization devices that limit mobility; osteoporosis; uncontrolled cardiovascular instability; neurological disorders other than spinal cord injury, eg, stroke, which may interfere with the performance of mental practice; medical diagnosis of dementia diseases such as Alzheimer&apos;s Disease, Vascular Dementia, Mixed Dementia, Lewy Body Dementia, Frontotemporal Dementia; clinical diagnosis of depression; use of antidepressant medications; cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-8n4hg2	Effects of Interferential Therapy on the Mechanisms of Pain in Chronic Low Back Pain Without a Specific Cause	recruiting	Intervention	2013-01-05	<NULL>	<NULL>	168	Effects of Carrier Frequency of Interferential Current on Modulation of Pain and Central Hypersensitivity in Patients with Nonspecific Chronic Low Back Pain: Randomized Controlled Trial	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2013-02-01	Universidade Cidade de São Paulo	Universidade Cidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8n4hg2	<NULL>	Patients presenting nonspecific low back pain for at least 3 months and with at least 3 of pain intensity in verbal numerical pain scale reported according to how they felt in the last 7 days, aged between 18 and 80 years, both genders	Patients with serious spinal diseases, such as fractures, tumors and inflammatory diseases such as ankylosing spondylitis, spinal root conditions confirmed by neurological tests (spondylolisthesis and disc herniation with neurological, narrowing spinal canal and others). Severe cardiorespiratory disease. Neurologial diseases. Pregnancy. Infection in the site of the current application. Cancer. Cardiac pacemaker. Skin lesions at the site of the current application. Alterations in sensibility and allergy in the region of electrodes placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-57yqwb	Effects of Intermittent Fasting and Low Calorie Diet on health parameters and body weight	Data analysis completed	Intervention	2020-04-29	<NULL>	<NULL>	3789	Metabolics effects and body composition of individuals submitted to Intermittent Fasting or Continuous Caloric Restriction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-10	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-57yqwb	<NULL>	"Be training regularly under professional supervision;
Be aged between 18 and 40 years;
Have a BMI equal to or greater than 24.99 kg / m2;
Agree to perform biochemical tests on your own"	subjects with kidney diseases; hormonal diseases and limiting joint diseases; heart disease and diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-9rh56ph	Effects of Intermittent Fasting in individuals with obesity and Obstructive Sleep Apnea	Recruitment completed	Intervention	2024-08-06	<NULL>	<NULL>	7180	Effects of a nutritional intervention with Time Restricted Eating in individuals with Obstructive Sleep Apnea	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-25	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-9rh56ph	<NULL>	Adult individuals aged between 18 and 60 years; with a Body Mass Index (BMI) between 25 and 40 Kg/m²; diagnosed with sleep apnea obstructive by polysomnography and/or medical diagnosis made in the last 6 months; whether or not they are being treated with oxygen therapy such as Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (BiPAP); of both sexes; with a feeding window between 11 and 14 hours	Individuals who have a serious illness such as cancer, liver or kidney disease; pregnant women or those with children up to two years old; institutionalised elderly people; individuals who are engaged in some kind of weight loss treatment or nutritional monitoring; those taking medication that interferes with metabolic rate (appetite suppressants, thyroid hormones); people who have a physical or intellectual disability proven by a medical diagnosis; people who are unable to take part in the proposed assessments; people who refuse to take part in the proposed assessments or interventions; people who have other sleep disorders such as insomnia, restless legs syndrome, narcolepsy; shift or night workers; participants who do not adhere to the proposed treatment; people who do not complete the proposed assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8mpyq4	Effects of interval running and cranberry supplementation on the immune system	Not yet recruiting	Intervention	2018-09-12	<NULL>	<NULL>	2193	Effects of interval training and cranberry supplementation in immunomodulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8mpyq4	<NULL>	Present VO2max classification between 35 and 55 ml.kg-1.min-1; be engaged in running training for at least three times a week; has no musculoskeletal disorder, autoimmune, cardiac, pulmonary or hypersensitivity disease; not use anti-inflammatory drugs or food supplements, including substances with antioxidant function, at least 30 days before the study period.	Do not meet 100% of the number of sprints in one or more high intensity interval training (HIIT) protocols; do not carry out any of the pre or post evaluation of HIIT; if they are absent in one of the six sessions of HIIT; present any injury or motor impairment to perform HIIT; present any infection of the upper respiratory tract during the experiment; antibiotic use within six months prior to study; regularly consume any dietary supplement composed of vitamins, minerals or bioactive compounds; do not consume any of the doses of cranberry proposed for the supplementation stage; present known allergy or intolerance to cranberry products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-4vktzw	Effects of intervals between sets on bodybuilding	Recruitment completed	Intervention	2017-03-17	<NULL>	<NULL>	1188	Effect of different recovery intervals between sets in resistance exercises to concentric failure in physically active individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-02	Universidade Federal de Alfenas	Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4vktzw	<NULL>	Physically active men with previous experience of at least six months in resistance training, with at least three weekly sessions.	Change in health condition; Nutritional or pharmacological supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-89ydgj	Effects of interventions with and without interactive video games in children with developmental coordination disorder	Recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1055	Comparative analysis of the effects of intervention with and without virtual reality on the motor performance and the energy expenditure in children with developmental coordination disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-89ydgj	<NULL>	"To study the initial stage will be included children of both sexes; aged 7-10 years; who are enrolled in selected schools; whose parents have signed the Consent Agreement and Informed and children the Free Consent Term Cleared up.
For the later stage of the study children will be included from the group of those with a positive indication for TDC; which have availability to participate regularly from interventions."	At this early stage of DCD tracking will be excluded children who have a physical disability; intellectual and or sensory impairments; autism spectrum disorder; orthopedic problems or other medical condition that may compromise the identification of the DCD. Children will be excluded if they do not meet the minimum of 10 intervention sessions; showing some clinical complications or making use of drugs that precludes their participation in training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-4g4sk8	Effects of intraarticular infiltration in  rheumatoid arthritis women´s knees	Recruiting	Intervention	2018-06-06	<NULL>	<NULL>	1877	Effects of Intraarticular Infiltration of Triamcinolone Hexacetonide in Rheumatoid Arthritis women´s knees on static, functional and inflammatory activity measurements: a randomized, controlled, blinded clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-01-24	Universidade Estadual Paulista - UNESP	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-4g4sk8	<NULL>	Diagnosis of RA according to the American College of Rheumatology (ACR) Classification Criteria of 1987 or Classification Criteria for RA 2010 of the ACR / EULAR; Age over 18 years; Female gender; Analog Visual Scale (EVA) of knee pain between 40 and 80 mm; EVA of knee edema between 40 and 80 mm; Be stable with drugs modifying the course of the disease in the last 3 months and / or oral corticosteroids in the last month; Presence of refractory knee injury in the last 3 months.	Injury and / or diseases symptomatic knee than RA; radiographic classification of Kellgren-Lawrence grade IV; Knee prosthesis in the target joint; prior realization of any IIAC in the last 6 months; Symptoms of systemic or local infection; reported hypersensitivity to the drug components or contraindication to the use thereof;Suspected or confirmed pregnancy; Physical therapy or other treatment in parallel to symptom in knee; Uncontrolled systemic arterial hypertension; Previous knee surgery to be evaluated; Skin lesions at the IIA site; Deficit vision or hearing or cognitive preventing the completion of the evaluations proposed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-2t9y4p	Effects of Intradialitic Exercise in patients with Chronic Kidney Disease	Recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3577	Effects of different modalities of intradialitic Exercise on aerobic capacity and quality of life of Chronic Kidney Patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal da Bahia(UFBA)	Hospital Geral Roberto Santos(HGRS)	https://ensaiosclinicos.gov.br/rg/RBR-2t9y4p	<NULL>	Chronic renal patients on dialysis who come to the hospital only to undergo hemodialysis sessions; hemodynamically stable(without vasoactive drugs), with medical clearance to perform physical exercises during the hemodialysis session; able to perform cycle ergometer and / or resisted exercises; older than 18 years; who walk without assistance.	Patients who have difficulty understanding the commands requested during physical exercise will be excluded, which will be evaluated by the Questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-7x28v3	Effects of isolated versus combined perineal preparation methods on perineal stretching and muscle strength	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	3379	Effects of isolated versus combined perineal preparation methods on perineal distensibility and muscle strength	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-29	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7x28v3	<NULL>	Pregnant women at the 33rd gestational week, in the age group 18-40 years, both primiparous and women who experienced miscarriages before the 21st week of previous pregnancies, who presented muscle strength &gt; 1 (based on the modified Oxford Scale) and who were subjected to vaginal palpation.	Participants who missed two consecutive interventions, who had urinary tract infections during the study and whose pregnancy came to an end before the last evaluation were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-5fysqrh	Effects of Ivabradine on Cardiac Circulation in patients with Angina	Recruitment completed	Intervention	2023-11-30	<NULL>	<NULL>	6622	Benefits of Ivabradine on Myocardial Perfusion in Chronic Stable Angina Pectoris	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2019-11-21	Medicina Nuclear do Alto da XV	Medicina Nuclear do Alto da XV	https://ensaiosclinicos.gov.br/rg/RBR-5fysqrh	<NULL>	Patients with chronic stable angina pectoris; aged between 18 and 70 years; who remain symptomatic despite of using beta blockers (maximum tolerated dose) and HR ≥ 70 bpm; sinus rhythm; LVEF &gt;40%; and any ischemia in baseline myocardial perfusion scintigraphy; performed with a physical stress test; in accordance with previous drug therapy	Unstable angina; Myocardial infarction &lt;6 months; LVEF &lt;40%; HR &lt;70 bpm; presence of left bundle branch block; pacemaker; patients who cannot perform a treadmill stress test (physical limitation); pregnancy, breastfeeding  or women in childbearing age who are not taking appropriate contraceptive methods; patients with hypersensibility to ivabradine or any component of the formula, cardiogenic shock, acute myocardial infarction, severe hypotension; and patients with contraindication to perform a myocardial scintigraphy.And also strict precautions (ie contraception) are needed in women of childbearing potential (because ivabradine and scintigraphy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-9d94td	Effects of Judo Practice on Blood Pressure, Endothelial Response and Autonomic Control of Adolescents with Overweight and Obesity	Data analysis completed	Intervention	2019-01-07	<NULL>	<NULL>	2428	Effects of Judo Practice on Blood Pressure, Endothelial Response and Autonomic Control of Adolescents with Overweight and Obesity: A Randomized Controlled Trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-05	Universidade Estadual do Rio de Janeiro	Universidade do Porto	https://ensaiosclinicos.gov.br/rg/RBR-9d94td	<NULL>	Children and adolescents between 9 and 12 years of age are either eutrophic or overweight or obese.	Kidney disease. Hematologic disease. Liver disease. Rheumatological disease. Neurological disease. Cardiovascular disease. Respiratory disease. Infectious disease. Endocrine disease. Any type of health condition that may interfere in the evaluation of outcomes as well as contraindicate the practice of sports. Regular use of medications mainly for weight control. Participation in weight control programs through diet or exercise in up to six months before the start of the experiment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-7zh8x7	Effects of Juice Fortification with Iron and Zinc in children	Data analysis completed	Intervention	2018-07-06	<NULL>	<NULL>	1973	Iron and Zinc Fortification effects on the Hemoglobin Level of preschool and school-age children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-25	Kilyos Assessoria Consultoria Cursos e Palestras LTDA	Kilyos Assessoria Consultoria Cursos e Palestras LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7zh8x7	<NULL>	Children from 0 to 17 years of age; both sexes; enrolled at the institution Reino da Garotada de Pos.	Individuals who are taking or have taken vitamin and/or mineral supplementation for the last two months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-10npxkxm	Effects of Kettlebell Workout and Detraining on Cardiorespiratory Capacity of Young Women	Terminated	Intervention	2024-01-29	<NULL>	<NULL>	6749	Effects of Kettlebell Training and Detraining on Cardiorespiratory Fitness in young women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-07	Universidade Federal do Espirito Santo	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-10npxkxm	<NULL>	being female; be between 18 and 30 years old; not having previous experience with the practice of kettlebell; present suitable physical conditions for tests and training (under the assessment of a cardiologist); score between “sedentary” and “irregularly active (A or B)” on the International Physical Activity Questionnaire (IPAQ); present cardiorespiratory fitness between “very poor” and “fair”, according to the classification of the American Heart Association (AHA) by VO2max (ml.kg-1.min-1).	Hypertensive subjects; smokers; subjects using medication, ergogenic or nutritional supplements known to affect metabolism or exercise performance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-4z4f48	Effects of Kinect Adventures games compared to conventional physical therapy in postural control of the elderly: a randomized clinical trial	Recruiting	Intervention	2016-04-12	<NULL>	<NULL>	1297	Effects of Kinect Adventures games compared to conventional physical therapy in postural control of the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Medicina da Universidade de São Paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-4z4f48	<NULL>	Seniors will be selected aged 60-80 years; of both genders; which did not show neurological and orthopedic disorders that promote disability of the elderly remain in bipedalism and wade unaided or cardiovascular disease uncompensated such as: angina; heart failure; high blood pressure decompensated; show no signs of cognitive impairment; the normal or corrected visual acuity measured by Snellen chart; normal or corrected hearing is clinically assessed by the whisper of the test; who did not have previous experience with the Kinect system and accepting to participate by signing the Informed Consent and Informed.	The elderly will be excluded that during the study period submit any clinical change that makes it impossible to perform physical exercises in standing position as: cardiorespiratory; orthopedic or neurological disorders; seniors who are missing for more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-10mxzptc	Effects of knee clicking on thigh muscles and walking in people with and without knee pain	Not yet recruiting	Observational	2023-10-18	<NULL>	<NULL>	6517	Repercussions of knee crepitus on objective aspects of the muscle and locomotor functions of people with and without Patellofemoral Pain: main project	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10mxzptc	<NULL>	Both genders; aged between 18 and 35 years; unilateral pain in the anterior, retro, or peripatellar region; insidious pain present for at least 3 months; self-reported pain intensity greater than 3 when quantifying the worst pain experienced in the knee in the week prior to screening, using a numerical scale ranging from 0 to 10; a score lower than 83 on the Anterior Knee Pain Score (AKPS) questionnaire	Bilateral knee pain complaints; history of surgery in any lower limb joint; history of patellar subluxation or dislocation; clinical evidence of meniscal injury; ligamentous instability; patellar tendinopathy; osteoarthritis in any lower limb joint; the presence of referred pain originating from the spine or any musculoskeletal condition more severe than patellofemoral pain; neurological disease; previous treatment for patellofemoral pain in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-7t6nzr	Effects of laser and physical exercise program in patients with knee arthritis	Recruiting	Intervention	2018-04-13	<NULL>	<NULL>	1709	Phototherapy and physical exercise program in patients with knee osteoarthritis: controlled, randomized and triple blinded study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-7t6nzr	<NULL>	Grade II or III of knee osteoarthritis; female subjects; classified as low active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version; age between 55 and 70 years; willingness to participate in the treatment plan.	They have cardiovascular, neurological or musculoskeletal disease that makes them unable to perform the exercise protocol; evidence of secondary, inflammatory or metabolic disease; use of conventional, non-conventional or alternative treatments that may potentially have effects on the results of the study (physiotherapy and / or injections of intra-articular corticosteroid or hyaluronic acid during the last 3 months); symptomatic hip OA; absolute contraindication for laser therapy as the presence of neoplasia in the region of lower limbs; individuals who have malnutrition or morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-335kdt	Effects of Laser application on the Single Hop Test of the knee	Recruitment completed	Intervention	2018-06-21	<NULL>	<NULL>	1922	Effect of Low Level Laser (LLL) in Functional Assessment (Single-Hop) of the knee	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-10	Universidade Anhanguera - Uniderp	Universidade Anhanguera - Uniderp	https://ensaiosclinicos.gov.br/rg/RBR-335kdt	<NULL>	women; professional handball player; practice of handball for at least four years and conducted training for at least five days a week; age between 15 and 30 years.	Any previous musculoskeletal injury to the knee, hip or ankle regions; participation less than 80% of the regular physical training of the handball team; use of any type of nutritional or pharmacological supplement and that contraindication to the use of the low power laser	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-9zbphr	Effects of laser on injuries of the posterior thigh	Recruiting	Intervention	2018-11-13	<NULL>	<NULL>	2335	Effect of Photobiomodulation on Hamstring Injury rehabilitation: a randomised clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9zbphr	<NULL>	Acute grade I or II Hamstring muscle injury.	Regular use of antiinflamatories, analgesics and/or alimentary supplements; Grade III muscle injury; Neural symptoms during evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-536hkwg	Effects of Laser on pain and return of sexual function after postpartum Perineal Trauma: a feasibility study	Not yet recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7994	Effects of Photobiomodulation on pain and return of sexual function after obstetric spontaneous Perineal Laceration: a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital Universitário Cassiano Antonio Moraes (HUCAM) da Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-536hkwg	<NULL>	Postpartum women treated at the Maternity of Hospital Antônio Cassiano de Moraes (HUCAM); normal birth with spontaneous perineal laceration of any degree; Singleton pregnancy; aged 16 or over; completion of the free and informed consent form	Infectious disease; hemorrhoid; bruise or varicose veins in the perineum	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-9wsg72	Effects of laser on preventing decreased sensitivity in women with breast cancer during chemotherapy	Recruiting	Intervention	2019-07-24	<NULL>	<NULL>	2845	Effects of laserpuncture in the prevention of altered tactile sensory perception in women with breast cancer during chemotherapy: randomized clinical trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2018-07-05	Universidade Federal de Minas Gerais	Hope Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-9wsg72	<NULL>	"Pathologic anatomic report of cancer;
Beginning of treatment with antineoplastic chemotherapy containing taxanes, platines, vinca alkaloids and bortezomib alone or in combination;
Absence of PSTA, identified by symptom reporting and stoichiometry test;
Adults above 18 years."	"Hoseniasis;
Diabetes melittus;
Cognitive deficits;
Other neuropathies, including those caused by tumor infiltration;
Absence of verbalization;
Pregnant;
Performance Status greater than or equal to 3;
Acupuncture in the last 6 months for neuropathy;
Alcoholism;
Skin problems in the irradiated area;
Presence of the tumor at the irradiation sites."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-46xj92	Effects of laser on strength and muscle fatigue	Recruiting	Intervention	2017-03-29	<NULL>	<NULL>	1198	Immediate effects of low-level laser therapy (780 nm) in muscle fatigue and metabolic performance: a randomized, crossover and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-27	Centro Universitário Uninovafapi	Centro Universitário Uninovafapi	https://ensaiosclinicos.gov.br/rg/RBR-46xj92	<NULL>	Young men; aged between 18 and 25 years; apparently healthy; sedentary.	Individuals who presented with a musculoskeletal disease or trauma in the last three months; those who took supplements or use of medication during the period of their participation in the study; not have consumed alcohol, large amounts of tea or coffee (more than two cups), or any other caffeine-rich food 24 hours before the test; have slept at least 8 hours  the night before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-2why5rd	Effects of laser therapy associated or not with mirror therapy on the functionality of the upper limbs and cognition of individuals who have suffered a Stroke	Data analysis completed	Intervention	2025-01-30	<NULL>	<NULL>	7700	Effects of Transcranial Laser Therapy associated or not with mirror therapy on the functionality of upper limbs and cognition in individuals affected by Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2why5rd	<NULL>	Both sexes; older than 18 years; clinical diagnosis of stroke in the chronic phase (more than six months); up to grade 2 on the Ashworth scale; ability to respond to simple commands using the least affected limb in pre-defined tasks; signed the Free and Informed Consent Form	Not having resources to travel to the study location; diagnosis of Transient Ischemic Attack; plegia; history of seizures and/or use of medication to control them; diagnosis of other associated neurological diseases; pregnancy; do not present motor sequelae in the upper limbs resulting from the stroke	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-1035vvfc	Effects of laser therapy in adults with fibromyalgia	Recruiting	Intervention	2022-10-20	<NULL>	<NULL>	5674	Effects of Modified Intravascular Laser Irradiation of Blood in adults with Fibromyalgia: a randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-15	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-1035vvfc	<NULL>	The study will include: women with age ranging from 18 to 60 years (the age limit is set to minimize structural changes due to aging), diagnosed with fibromyalgia according to the diagnostic criteria which was set in the 2016 modification of the American College of Rheumatology (WOLFE et al. ., 2016). In general, the participants must have generalized pain in at least 4 of 5 body regions for at least 3 months, with a score of 7 on the Widespread Pain Index (WPI) questionnaire and 5 on the Severity Scale /Symptom Severity Scale (SSS), or WPI between 4 to 6 and SSS ≥ 9. In that last case, the fibromyalgia symptom scale (FS- Fibromyalgia Severity) is added, which is defined as the sum of the previous two questionnaires as a complete component of the diagnostic criteria, as presented in ANNEX I. According to UFPR‘s Normative Instruction No. 01/2021 (PRPPG/PROGRAD/PROEC), only participants who present a complete vaccination schedule or the ones who present negative results for SARS-CoV-2.0 infection in periodic examination reports of RT-qPCR or antigen type at every 72 hours will be allowed to be included in this study.	Women with cognitive deficits determined by achieving less than 13 points in the Mini-Mental State Examination will be excluded of this study (ANNEX 2) (SANTOS et al., 2010); hearing loss which prevents the understanding of verbal instructions; neurological disorders and/or trauma-orthopedic conditions that prevent the participant from carrying out the assessments and/or the proposed intervention; pregnant or lactating women; having an acute or terminal illness; presence of other pathologies at the application site; women who are undergoing physiotherapeutic treatment concomitant to the study; women who make use of steroids which which interfere with the action of ILIB; women who have modified their pharmacological treatment during the study or month prior to the intervention; women who have not taken at least the first dose of the Covid-19 vaccine; and any contraindication for the application of ILIB, namely: cardiogenic shock, arterial hypotension, heart disease, stages II and III  of circulatory failure, anemia, sick sinus syndrome, existence of blood coagulopathies (MIKHAILOV, 2009)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-7p58r6	Effects of laser therapy on orofacial muscles	Not yet recruiting	Intervention	2020-06-02	<NULL>	<NULL>	3895	Effects of photobiomodulation on orofacial muscles	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7p58r6	<NULL>	Age between 18 and 60 years; sign the Informed Consent Form	craniofacial anomaly; use of myorelaxing and/or anti-inflammatory drugs; signs and/or symptoms of temporomandibular disorder; photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the application site; history of cancer; use of a pacemaker or other electronic implant; presence of a beard or mustache at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-93sy24z	Effects of Laser Therapy on pain and muscle activity in patients with Chronic Low Back Pain	Recruiting	Intervention	2021-03-08	<NULL>	<NULL>	4567	Effects of Low-level Laser on the pain and activity of lumbar spine stabilizing muscles in individuals with Chronic Non-specific Low Back Pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Anhembi Morumbi	Unidade de Ensino Superior do Sul do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-93sy24z	<NULL>	Patients with clinical diagnosis of chronic non-specific low back pain will be included (with the presence of symptoms for more than three months); age between 18 and 59; both the sexes; and who have no other pathology in the spine, which will be verified by the clinical evaluation of individuals.	Those with systemic diseases will be excluded; who are undergoing another type of treatment; individuals with neurological disorders; diagnosed with vascular disease and metabolic disease; with the presence of neoplasms and that are in effect of any anti-inflammatory or analgesic drug by prescription or self-medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-56gdnqk	Effects of Laser Therapy on the lips of mouth-breathing children	Not yet recruiting	Intervention	2025-10-17	<NULL>	<NULL>	8423	Effects of Orofacial Myofunctional Therapy combined with Photobiomodulation in mouth-breathing children: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-56gdnqk	<NULL>	Mouth-breathing children of both sexes, aged between 5 and 12 years; who have signed the Informed Assent Form (IAF) and whose respective guardian has signed the Informed Consent Form (ICF); who have not used muscle relaxant and/or anti-inflammatory medication within the 48 hours prior to data collection; participants who do not present contraindications to phototherapy	Failure to complete all proposed tasks; low quality of the electromyographic signal; absence of dento-skeletal conditions necessary to achieve lip sealing; obstruction that prevents nasal breathing; lip sealing performed with effort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-5n3mtj	Effects of laser therapy on the masseter of children with spastic cerebral palsy	Recruiting	Intervention	2015-09-14	<NULL>	<NULL>	612	Effects of photobiomodulation on the masseter of children with spastic cerebral palsy	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Universidade Cruzeiro do Sul	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5n3mtj	<NULL>	"Cerebral palsy diagnosis of spastic type;
with or without complaints of pain mouth opening; 
difficulty in performing oral hygiene;
utensils locking used for food or for oral hygiene;
trauma story in oral tissues"	Patients diagnosed with cerebral palsy spastic type associated with syndromes or other disabling condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-3kmpr6s	Effects of laser treatment and indirect moxibustion in knee osteoarthritis	Recruitment completed	Intervention	2021-06-01	<NULL>	<NULL>	4714	"Evaluation of the effects of two non-pharmacological therapies:
Laserpuncture and indirect moxibustion in acupuncture points in the treatment of patients diagnosed with knee osteoarthritis"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-3kmpr6s	<NULL>	To be included in the study, the patient / volunteer must accept to participate in the research (signing the informed consent form); be diagnosed with OAJ with levels of 2 - 4 according to the degree of Kellgren and Lawrence in the x-ray exam, evaluated by the orthopedists of the unit (21); be aged between 45 and 80 years; knee pain and functional disability for at least three months; and medical indication to perform physiotherapeutic treatment. Without a history of local medications or surgeries for at least 12 months and without the use of medication with continuous systemic effects, such as analgesics, anti-inflammatories, chondroprotectors, corticosteroids, NSAIDs, for treatment for at least 90 days, being guided by the doctors of the unit not to use these medications.	"Not participate in the study, patients / volunteers that have full or partial prosthesis in one or both knees or hips; symptomatic hip osteoarthrosis, knee ankylosis; cancer; neurological diseases that affect locomotion; they will also be exclusion criteria, and that after the invitation, they do not feel safe, embarrassed and / or pressured to participate in the research. Patients who underwent local infiltrations for less than 12 months, patients who underwent surgical interventions on the knee for less than 12 months, patients using analgesic medications, NSAIDs, corticosteroids, chondroprotectors for less than 90 days.
Patients with some type of comorbidity who need any of the above types of medication, as well as patients with severe and / or decompensated cardiovascular diseases, patients with decompensated Diabetes Mellitus, rheumatological diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-5q5t5z	Effects of lavender essential oil on sleep in postmenopausal women with insomnia	Recruitment completed	Intervention	2019-12-27	<NULL>	<NULL>	3307	Effects of lavender essential oil inhalation on sleep quality in postmenopausal women with insomnia	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-04-24	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5q5t5z	<NULL>	Postmenopausal women between 48 and 65 years old; Hysterectomized and / or oophorectomized  women with follicle stimulating hormone (FSH) concentrations 30 mUl / mL; They haven&apos;t used hormone therapy in the last 3 months; They haven&apos;t used sleep medications in the last month; Stop-Bang questionnaire with score &lt;3; Clinical diagnosis of insomnia	Diagnosis of uncontrolled clinical diseases; History of serious neurological or psychiatric disorders; In treatment for insomnia or for complaints of postmenopausal symptoms; In drug treatment with the use of benzodiazepines, antihistamines, hypnotics, hypnotic phytotherapics, sedatives, antidepressants, antipsychotics, stimulants (amphetamine, caffeine, modafinil), corticosteroids; They have previously received aromatherapy treatment; They have been practice meditation or yoga for sleep problems; If they will presente repulsion to the odor of Lavandula angustifolia essential oil or sunflower oil; Workers in shift; Illiteracy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-4cxw37	Effects of laying on of hands in heart sugery&apos;s patients	Recruiting	Intervention	2019-05-03	<NULL>	<NULL>	2654	Effects of laying on of hands in patients submitted to cardiac surgery: clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Escola de Enfermagem da Universidade de São Paulo	Pronto-Socorro Cardiológico Universitário de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4cxw37	<NULL>	Patients older than 18 years, with preoperative risk assessment classified as low or medium by Euroscore (SÁ et al, 2010). Thus, patients will have Euroscore 0 to 5 points	To affirm that it does not believe in the possibility that the imposition of hands may be beneficial to health, aortic or congenital cardiac diseases, emergency or emergency surgeries, the use of antipsychotics and anxiolytics, the impossibility of walking, mental and cognitive alterations that (concomitant stroke or sequelae, brain tumors, intracranial hypertension, cognitive and behavioral deficits, sensory-motor deficits), previous renal, digestive and pulmonary diseases, infections acquired before the surgical procedure; refusal to participate in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-7jv6k2n	Effects of Leucine Supplementation in Patients with Stomach and Bowel Cancer.	Recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8418	Leucine supplementation in patients with gastrointestinal cancer: effects on body composition and inflammatory parameters	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-11-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7jv6k2n	<NULL>	Patients with gastrointestinal cancer (stomach, esophagus, colon, or rectum), with and without weight loss. Ages between 40 and 90 years. Both sexes	Neoplasms of organs adjacent to the gastrointestinal tract, such as the pancreas, liver, or small intestine. Autoimmune diseases, obesity, inflammatory bowel disease, Crohn&apos;s disease, acquired immunodeficiency syndrome, chronic obstructive pulmonary disease (COPD), and other inflammatory diseases were excluded. The presence of other types of cancer, kidney or liver failure, psychotic disorders, or dementia, as well as any cognitive condition that compromises the ability to respond to the questionnaires, was also considered an exclusion criterion. Individuals who used anti-inflammatory drugs or corticosteroids during the supplementation period were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-7k4ttg	Effects of levodopa on masticatory and oral sensory function in Parkinson’s Disease	Data analysis completed	Observational	2018-05-10	<NULL>	<NULL>	1777	Oral health and chewing function in patients with Parkinson’s Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-10	Faculdade de Odontologia de Piracicaba	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7k4ttg	<NULL>	"Case group: volunteer with Parkinson&apos;s disease; both genders; age over 60 years; edentulous or partially dentate; with and without removable dental prostheses.
Control group: Paired study"	"Case group: volunteers should not have neurodegenerative disease, except for Parkinson&apos;s disease; and should not have not neurological disorders in which parkinsonism comprises the clinical condition.
Control group: Paired study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-8kdv3pt	Effects of Light Therapy and Manual Manipulation Technique on improving physical capacity and reducing pain in adults subjected to Muscle Damage	Not yet recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7132	Effects of Photobiomodulation and Osteopathy on blood and salivary parameters, pain perception and physical performance in young adults undergoing Muscle Damage induced by physical exercise	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal de Jataí	Universidade Federal de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-8kdv3pt	<NULL>	The study will include male people; aged between 18 and 35 years; Caucasian and unused to performing plyometric jumps in their usual training; Participants must also have at least 6 months of experience with resistance training	Individuals who use nutritional supplements or anti-inflammatory and pain medications in the last seven days will be excluded; having consumed alcohol or ergogenic drinks 72 hours before the tests; present musculoskeletal injury; not carrying out all the collection stages and/or giving up during the study; practitioners of sports that involve plyometric jumps	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-4nnkfb	Effects of light therapy on physical performance and recovery of postmenopausal women submitted to a high intense exercise session	Recruiting	Intervention	2019-07-22	<NULL>	<NULL>	2830	Effects of Light-Emitting Diode therapy on physical performance, on inflammatory and oxidative stress markers, and on hemodynamic and cardiac autonomic responses of postmenopausal women submitted to a high intense exercise session	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade de Medicina da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4nnkfb	<NULL>	Women; amenorrhoea of at least 12 months; able to exercise; healthy; do not present functional limitations that prevent them from exercising on the treadmill; do not present chronic diseases (diabetes, hypertension and coronary artery disease) or any pathology that can prevent their participation in physical activity; do not perform hormone replacement therapy; do not use medications that may interfere in the results of the survey; non-smoker.	Chronic diseases (diabetes, hypertension and coronary artery disease) or any pathology that may prevent their participation in physical activity; use of hormone replacement therapy; the use of medications that may interfere with the results of the research; smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-54wq2nb	Effects of long jack suplementation on strength in weightlifing men	Data analysis completed	Intervention	2021-05-07	<NULL>	<NULL>	4626	Effects of Long Jack supplementation on strength in resistance trained man	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal de São Paulo campus Baixada Santista	Universidade Federal de São Paulo campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-54wq2nb	<NULL>	Healthy male individuals; 20-40 years old; practiced resistance training for at least 3 months non-interuptly.	participants will be excluded if they take some medication; sterois and supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-82bcmz	Effects of low level laser therapy in muscle fatigue of elderly women pre and post a quadríceps femoris exercise program	Recruiting	Intervention	2016-04-28	<NULL>	<NULL>	819	Effects of low level laser therapy in peripherical muscle fatigue in elderly women submitted to a program of muscular strength	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-31	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-82bcmz	<NULL>	"No pain or dysfunction in trunk and lower extremities 
Full active range of motion of hip, knee and ankle
Absence of fracture or previous surgery in the spine and lower extremities
Considered insufficiently active for IPAQ"	"Pain in the lower extremities or trunk; 
Restriction in range of motion of hip, knee and ankle; 
History of trauma or previous surgery in  lower extremities or spine; 
History of quadriceps femoris muscle injury; 
Subluxation of  hip joint; 
Osteoarthritis in  hip and knee; 
Rheumatic e, degenerative or neurological diseas; 
Diabetes mellitus and fibromyalgia; 
Subjects with uncontrolled hypertension."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-3f8rzs	Effects of low level laser therapy in the electromyographic fatigue of bíceps brachi muscle before and after a resistive program training in young males	Recruiting	Intervention	2016-04-25	<NULL>	<NULL>	805	Effects of low level laser therapy in the electromyographic fatigue, in the blood lactate, and in the inflamatory markers after induced biceps  biceps brachi muscle fatigue before and after a resisitive  program training in young males	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3f8rzs	<NULL>	"Full active range of motion and no pain in the shoulder, elbow and wrist; 
Absence of fracture or previous surgery on spine and upper extremities; 
Considered insufficiently active for IPAQ; 
Not be in training for at least six months."	"Restriction in range of motion of shoulder, elbow and wrist; 
History of trauma or previous surgery in trunk; upper extremities; 
History biceps muscle injury; 
Subluxation of the glenohumeral joint; 
Rheumatic, neurological or degenerative disease;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-2xq4vw4	Effects of low oxygen intervals during exercise on human body function	Recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7280	Effects of intermittent hypoxia recovery on molecular, metabolic and neuromuscular variables	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2xq4vw4	<NULL>	Man; healthy; aged 18 to 35 years old	History of anemia in the last six months; history of lower limb injury in the last six months; and presented low ferritin levels at the beginning of the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-107jk4tn	Effects of low-carbohydrate diets in the treatment of chronic diseases	Recruiting	Intervention	2021-11-03	<NULL>	<NULL>	5012	Effects of low-carbohydrate diets in the treatment of chronic non-communicable diseases.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Amanda Aparecida Felizardo	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-107jk4tn	<NULL>	Have a diagnosis of type 1 diabetes Mellitus; present from 21 to 50 years of age of both sexes; have glycated hemoglobin (Hb1Ac) &gt;7.0%; agree to follow all parameters considered in the protocol for the treatment of type 1 diabetes with a low-carbohydrate diet; belong to any region of the country; have creatinine clearance &lt; 60; use a glucometer or sensor (Libre, Flash Glucose Monitoring) for minimum of 7 measurements per day; perform a fundus examination for the diagnosis of diabetic retinopathy; have mild retinopathy treated (to be evaluated by the ophthalmologist and endocrinologist); be willing to consume, during the first 15 days of the protocol, the amount of 130g of daily carbohydrates; sign the authorization to participate in the research through the Informed Consent Form (TCLE); agree to perform all laboratory tests before starting the survey, three months after the start of the 50g daily carbohydrate phase, and at the end of the sixth month of the survey.	Have moderate to advanced diabetic retinopathy (to be evaluated by the ophthalmologist and endocrinologist); present reports or suspicion of gastroparesis; have an eating disorder, such as binge eating; be an athlete; use an insulin pump; have a pregnancy diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-9r769bf	Effects of Low-level Laser Therapy on the performance of the gluteus medius muscle	Recruitment completed	Intervention	2021-11-03	<NULL>	<NULL>	5013	Effects of Low-level Laser Therapy on the performance of the gluteus medius muscle	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-10	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9r769bf	<NULL>	healthy individuals; women; age; BMI; individuals active according to the International Physical Activity Questionnaire; availability to participate in the intervention	Cardiovascular or neurological or disease; such as spine or knee pathologies; absolute contraindication for phototherapy, male, above 24 (age)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-3yt94dn	Effects of Low-power Laser Therapy associated with Selective Caries Removal on Postoperative Sensitivity reduction in Deep Cavity Restoration	Recruitment completed	Intervention	2024-02-27	<NULL>	<NULL>	6814	Effects of Photobiomodulation (PBM) associated with Selective Removal Cavity in reduction of Post-operative Sensitivity in Deep Cavity Restorations. A double blind randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal do Pará	Centro Universitário FIBRA	https://ensaiosclinicos.gov.br/rg/RBR-3yt94dn	<NULL>	Vital permanent teeth with class I caries cavities, distance of up to 1mm from the pulp chamber. Good oral and general health conditions.	Teeth that present peripicopathies, sensitivity to percussion, thickening of the periodontal ligament or incomplete rhizogenesis. Spontaneous pain indicative of irreversible pulpitis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-98nzfnq	Effects of Lower Limb Resistance Training with different planning models on Strength and Lean Mass of military personnel	Data analysis completed	Intervention	2023-01-13	<NULL>	<NULL>	5818	Comparison between the effects of Periodized Strength Training Programs, Machine versus Free Weight, on parameters of neuromuscular fitness in Brazilian Army militaries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Instituto de Pesquisa da Capacitação Física do Exército - IPCFEx	Escola de Educação Física e Desportos da Universidade Federal do Rio de Janeiro - EEFD/UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-98nzfnq	<NULL>	have answered negatively to all the sentences of the Physical Activity Readiness Questionnaire (PARQ); be a member of the Brazilian Army;  be between 18 and 26 years old; not having had any type of musculoskeletal injury for at least the last six months; male individuals	not being able to fully implement the predicted protocols; not being able to participate in the intervention due to medical recommendations; missing 3 (three) training sessions; make use of medications and/or supplements that may interfere with the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-3bf8q5z	Effects of lowerlimb Strengthening in athletes with Achilles Tendon Pain	Recruiting	Intervention	2022-12-30	<NULL>	<NULL>	5794	Effects of multi-joint lowerlimb Strengthening in recreational athletes with Achilles Tendinopathy: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Minas Gerais	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3bf8q5z	<NULL>	Volunteers of both genders; aged between 18 and 45 years old; with clinical diagnosis of achilles tendinopathy (insertional or mid-portion); enrolled in sports activities and tasks that load the achilles tendon (e.g.  jump, running); having presence of achilles tendon pain for at least three months.	Subject with history of lowerlimb surgery; history of lowerlimb injury in the past six months; have done corticosteroids infiltration in the past six months; have used Fluoroquinolones in the past 12 months; clinical diagnosis of diabetes, obesity, familial hypercholesterolemia  or any other systemic disease that impairs the performance of physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-7nd6kcb	Effects of lung expansion manoeuvres compared to standard physical therapy of adult subjects receiving mechanical ventilation: A randomized controlled clinical trial	Recruitment completed	Intervention	2021-10-07	<NULL>	<NULL>	6129	Effects of Pulmonary Ventilation Techniques in a Patient Under Mechanical Ventilation: a controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal de Juiz de Fora	Hospital Santa Casa de Misericórdia de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7nd6kcb	<NULL>	Participants aged 18 or over will be included; on mechanical ventilation between 12 and 48 hours; not participating in a palliative care program.	Hemodynamic instability (heart rate &gt; 130 bpm and/or mean arterial pressure &lt; 60mmHg); severe bronchospasm; undrained pneumothorax; pulmonary hemorrhage; thoracic trauma; thoracic surgery performed in the last 24 hours; patients transferred to another hospital.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-6pws57	Effects of luting agents on performance of metal free crowns	Recruiting	Intervention	2019-12-18	<NULL>	<NULL>	3296	Effects of gic luting agents on the clinical performance of metal free crowns - a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-6pws57	<NULL>	Age between 18 and 70 years old, Health adult patient older than 18 years old; Patient requesting two full-crown restorations (both on anterior or both on posterior teeth); Occlusal contact of the tooth to be restored with the antagonist tooth; The selected teeth do not require endodontic treatment our were (or will) be properly endodontically treated before the research treatment; The selected tooth has not structural loss OR have more than ½ of remaining crown structure OR have less than ½ of the crown structure but can be restored after receive intraradicular post; Tooth mobility degree 0 or 1 according to Miller (no mobility or up to 1mm).	Signs of bruxism; Severe periodontal disease on all teeth or on the teeth indicated for treatment; Systemic disease that counter indicate dental treatment; Pregnancy; Allergy to the restorative materials; Selected tooth showing mobility degree 2 or 3 according to Miller; Clinical or radiographic signs of active periapical or bifurcation lesions; Invasion of the biologic width; Root fractures; Tooth with painful symptoms and impossible to treat, being extraction indicated.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-5jv4qs	Effects of Magnesium on Endothelium in Hypertensive	Recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2194	Effects of Magnesium on Endothelial Function in Hypertensive patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-27	Hospital Universitário Pedro Ernesto	Universidade do Estado do Rio de Janeiro - UERJ	https://ensaiosclinicos.gov.br/rg/RBR-5jv4qs	<NULL>	"Outpatient patients between the ages of 40 and 65 years.
Both genders, with postmenopausal women.
Hypertensive patients with systolic blood pressure greater than or equal to 140 mmHg and / or diastolic blood pressure greater than or equal to 90 mmHg.
In pharmacological treatment, with stable use of at least two antihypertensive classes in the last four weeks.
Patient with body mass index less than or equal to 35 kg / m2.
Patients with habitual food consumption maintained for at least four weeks.
Signature of the Informed Consent Term (SICT)."	"Smoking.
Diabetes Mellitus.
Hormone replacement therapy.
Hypertension with blood pressure greater than 160/100 mmHg.
Use of beta-blocker or statin.
Evidence of secondary hypertension.
Changes in thyroid function, chronic renal and liver diseases.
Clinically evident coronary disease with prior history of acute myocardial infarction and / or myocardial revascularization, with clinical signs of heart failure, symptomatic cardiac arrhythmia, or clinically significant valve disease, prior cerebrovascular accident.
Use of nutritional supplements (vitamins, minerals) for up to seven days before the start of the study.
Patients presenting with any serious illness and any condition, illness or therapy that, in the opinion of the investigator, may impair the results, interfere with the study objectives or jeopardize patient safety."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2xnxbs2	Effects of magnetic stimulation over the head on muscle tone in individuals with Multiple Sclerosis	Recruitment completed	Intervention	2023-03-30	<NULL>	<NULL>	5974	Effects of Transcranial Magnetic Stimulation on spasticity in Sclerosis Multiple	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-12	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2xnxbs2	<NULL>	Participants over 18 years of age with a confirmed diagnosis of Multiple Sclerosis and with Relapsing-Remitting, Primary Progressive and Secondary Progressive subtypes; participants who present quadriceps spasticity assessed by the Ashworth scale grade 3; participants who show a quadriceps motor evoked potential response.	Application of phenol, botox, or other procedures that interfere with quadriceps muscle tone within six months or less; recent fracture or surgery in lower limbs; contracture or deformity in the ankles; contraindications for the use of trancranial magnetic stimulation as history of seizures or refractory epilepsy, metal brain implants, brain tumors, or skin lesion at the site of application.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-9x5jfn	Effects of manipulation of foot muscles in people who have acquired brain injury	other	Intervention	2012-03-13	<NULL>	<NULL>	152	Manipulation of intrinsic muscles of the foot in people with acquired brain injury	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-09	Centro Universitário de Rio Preto - UNIRP	Centro Universitário de Rio Preto - UNIRP	https://ensaiosclinicos.gov.br/rg/RBR-9x5jfn	<NULL>	"Patients with acquired brain injury;
Ability to stay in standing position without assistance of the upper limbs."	"Do not assume standing position; 
Age below 18 years; 
Owning a pathology that prevents the collection of results."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6b8jvpk	Effects of manual gripping exercise with a stress ball on blood pressure and heart rate variability in hypertensive elderly women	Recruiting	Intervention	2025-02-06	<NULL>	<NULL>	7724	Effects of isometric handgrip exercise performed with a ball antistress in the cardiovascular responses of elderly hypertensive women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Educação da Universidade Federal da Bahia - FACED	Faculdade de Educação da Universidade Federal da Bahia - FACED	https://ensaiosclinicos.gov.br/rg/RBR-6b8jvpk	<NULL>	being female; being aged 60 years or older; having been diagnosed with hypertension through a medical report or self-reporting as having hypertension and being on a prescribed antihypertensive medication; having been on antihypertensive medication at a maintained dose for the last 6 months; not having secondary hypertension and/or target organ damage; not using medications that directly affect cardiac autonomic regulation (e.g., beta-blockers and non-dihydropyridine calcium channel blockers, antidepressants); not having other cardiovascular diseases, aside from hypertension; not having grade II obesity or higher; not having diabetes with complications or using insulin; not having orthopedic conditions that prevent the practice of isometric resistance training; not being a smoker or having smoked in the last year; not undergoing hormone therapy	present safety blood pressure (BP) above 160 mmHg for systolic blood pressure (SBP) and/or 100 mmHg for dyastolic blood pressure (DBP) on the day carrying out the exercise in two consecutive reschedulings;  impossibility to continue a collection for health reasons or any other reason raised by the participant; decide leave the study voluntarily; impossibility of carrying out experimental sessions intervention and control with a time interval of less than 3 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-3c8wwt	Effects of Manual Osteopathy Treatment on the Signs and Symptoms of Lumbar Pain Volunteers	Recruiting	Intervention	2019-10-15	<NULL>	<NULL>	3091	Effects of Osteopathic Manipulative Treatment on the Signs and Symptoms of Low Back Pain volunteers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-18	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3c8wwt	<NULL>	Present disability due to low back pain; classified by the Oswestry questionnaire; be between 18 and 50 years old	Presence of tumors of any kind; Being on medical treatment for low back pain or other symptoms and for depression; Having undergone any surgical procedure on the lumbar spine; Carriers of systemic, neurological, rheumatological diseases; Pregnancy; Being on physical therapy treatment; osteopathic pain in the last 3 months; have had amputation of the first phalanx of the fingers; have a pacemaker; have had myocardial infarction; have eaten or smoked in the last 2 hours prior to collection; have consumed alcohol in the last 24 hours prior to collection; Being on hormones and antidepressants; If the volunteer is using these drugs, the pharmacokinetics of the drug will be analyzed in the scientific literature, to verify if the time of effect of the drug ceased when the bioelectrographic collection; If the volunteer is still on the medication, her data will not be used in the analysis of the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-7f4jy8j	Effects of Manual Techniques applied to the cervical spine on the nervous system of the elderly	Data analysis completed	Intervention	2022-08-22	<NULL>	<NULL>	5566	Effects of Osteopathic Manipulative Treatment (OMT) on the functionality of patients with Congestive Heart Failure: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7f4jy8j	<NULL>	Age equal to or greater than 60 years; physically active; normotensive	Subjects unable to remain in the stand up position for at least 10 minutes; patients with rheumatological diseases; subjects with acute and/or chronic joint pain; subjects with cardiovascular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-9ybbch	Effects of Manual Techniques versus an Exercise Program on Low Back Pain in Karate Fighters: experimental study	Data analysis completed	Intervention	2019-10-10	<NULL>	<NULL>	3770	Effects of Manual Therapy versus an Exercises Program on Low Back Pain in karate fighters: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-30	centro universitário unieuro	centro universitário unieuro	https://ensaiosclinicos.gov.br/rg/RBR-9ybbch	<NULL>	Individuals that presented with acute lower back pain; Karate practitioner for at least six months; That they agreed not to undergo any physiotherapeutic treatment or other rehabilitation procedure during the study period; Individuals who did not change their physical exercise habits during the study period.	"They had degenerative pathologies; Cardiovascular diseases,
Metabolic diseases; History of musculoskeletal injury in a period of six months prior to the survey; Cognitive deficit or non-collaborative patient; Illiterate or had difficulty understanding; Missed two consecutive appointments."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-7sf8tq5	Effects of manual therapy associated or not with cervical manual therapy in pain, mouth opening and function in patients with temporomandibular disorder (TMD)	Recruitment completed	Intervention	2024-08-19	<NULL>	<NULL>	7235	Short-term effects of orofacial manual therapy associated or not with cervical manual therapy in pain, maximum mouth opening (MMO) and function in patients with temporomandibular disorder (TMD)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-29	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7sf8tq5	<NULL>	Age 18 to 60 years; Reside in the city of Porto Alegre; Signs and symptoms of TMD, with muscular characteristics, for at least three months, with a diagnosis of orofacial pain according to the DC/TMD classification; People with internet access; Responded to the CF-PDI through an online form; Read and consent to the Free and Informed Consent Form and understood the necessary guidelines for carrying out the evaluations proposed in this research.	Be undergoing physiotherapeutic treatment for the head and neck, diagnosis of fibromyalgia, history of trauma or surgery to the head and neck and recent dental prosthesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-9zvptxg	Effects of Marijuana on the quality of life of Cancer patients	Recruiting	Intervention	2023-03-28	<NULL>	<NULL>	5967	Effectiveness of Medicinal Cannabis on the quality of life of Oncological patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9zvptxg	<NULL>	People over 18 years of age; patients who will start treatment with medical cannabis; who are newly linked to cannabis associations; who have been diagnosed with cancer; and who are undergoing cancer treatment.	Interdicted and/or curated patients; under 18 years of age; using antidepressants or anxiolytics, and people undergoing palliative treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-48k5jm	Effects of Massage on leg muscles on balance	Recruitment completed	Intervention	2018-05-14	<NULL>	<NULL>	2389	Effects of the Massage application time in the recovery of muscle damage in the hip and knee extensor muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-15	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-48k5jm	<NULL>	Young volunteers; men; healthy; physically active; not drug users that affect strength or balance	Volunteers who have musculoskeletal impairment of the lower limbs; volunteers with diseases (labyrinthitis, migraine) that compromise the balance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5pj5bb	Effects of mate tea consumption on muscle strength recovery and indicators of inflammation and damage caused by free radicals after exercise	Recruiting	Intervention	2015-02-23	<NULL>	<NULL>	399	Effects of mate tea (ilex paraguariensis) consumption on muscle strength and concentration of inflammatory and oxidative stress markers after eccentric exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-12	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5pj5bb	<NULL>	Healthy male, 19 to 30 years old; physically active.	Athletes; participation in formalized resistance or aerobic training programs in the previous three months preceding the study; smoking; having any disease, infection, or inflammatory processes; history of upper limb injury; and using any medication, ergogenic aids, herbal supplements, or vitamin/mineral supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-83hc4bw	Effects of mate tea ingestion (Ilex paraguariensis) before aerobic exercise on metabolic, muscle damage and oxidative stress indicators	Data analysis completed	Intervention	2024-04-17	<NULL>	<NULL>	6944	Effect of ingesting mate tea (Ilex paraguariensis) before exercise on energy metabolism and metabolic indicators	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-22	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-83hc4bw	<NULL>	Male; age between 18 and 35 years; regular practitioner of aerobic exercise; absence of metabolic diseases; no aversion or intolerance to study foods; not a user of tobacco, alcohol, supplements, or medications	Negative response to all questions in the Pre-activity Readiness Questionnaire (PAR-Q); below-average coronary risk; body fat percentage less than 25%; and Body Mass Index between 18.5 and 24.9 kg/m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-7dq3v7b	Effects of maternal obesity on the kinetic disposition of misoprostol during labor induction	Data analysis completed	Observational	2021-08-13	<NULL>	<NULL>	4834	Effects of maternal obesity on the pharmacokinetics of misoprostol during labor induction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2015-05-25	Faculdade de Medicina de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7dq3v7b	<NULL>	Parturients (&gt; 18 years old); single pregnancy; BMI characterized as: not obese, obese grade 1, obese grade 2 and morbid obesity; without fetal complications; hospitalized for induction of labor with misoprostol 25ug vaginally.	patients with renal failure and chronic liver diseases (identified by laboratory tests); congestive heart failure; patients who suffered a heart attack or stroke less than six months ago; patients with a history of severe chronic obstructive pulmonary disease; parturients who used inducers or inhibitors CYP; previous cesarean section	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-4fvrqx	"Effects of maxillary advancement with facial mask on Class III orthopedic treatment
between patients with and without cleft lip by tomographic comparison"	Recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3455	Effects of Maxillary Protraction with Facemask on Class III Orthopedic Treatment between patients with and without Complete Unilateral Cleft Lip and Palate through Tomographic Comparison	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4fvrqx	<NULL>	"Group I: Individuals with complete and unilateral cleft lip and palate between 5 and 13 years of age;occlusal indexes Goslon 3, 4;
Agree to participate and sign the free and informed consent form
Group II: Individuals with deciduous dentition or in the 1st transitional period of mixed dentition; agree to participate and sign the free and informed consent form"	Patients who do not perform the requested exams; patients who do not return to reevaluation appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-56nsh92	Effects of meals rich in ultra-processed foods on the metabolism of overweight individuals	Data analysis completed	Intervention	2023-07-11	<NULL>	<NULL>	8028	Effects of meals rich in ultra-processed foods compared to meals without ultra-processed foods on energy metabolism, satiety hormones, and autonomic function in individuals with excess weight	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Univerisidade Federal de Alagoas	Univerisidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-56nsh92	<NULL>	Individuals aged between 19 and 60, with obesity defined by 2 of the 3 following criteria: body mass index between 25 and 40 kg/m2; waist circumference greater than or equal to 88 cm for women and greater than or equal to 102 cm for men; body fat percentage greater than or equal to 35% for women and greater than or equal to 25% for men, determined by bioelectrical impedance; who want to lose weight, but who have had a stable weight for at least 1 month at the time of inclusion	Individuals using chronic medications (antidiabetics, antiretrovirals, immunosuppressants, antidepressants); celiac or gluten-sensitive individuals; vegetarians or vegans; who have a condition that makes it impossible to perform anthropometry or measure the components of energy expenditure; menopausal women; pregnant women or nursing mothers; or who have already undergone any surgical intervention for weight loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6zm7yvg	Effects of meals without or rich in ultra-processed foods and with low or high caloric density on spontaneous food consumption, motivation and exercise tolerance in healthy adults	Recruiting	Intervention	2025-06-13	<NULL>	<NULL>	8049	Effects of meals without or rich in ultra-processed foods and with low or high energy density on ad libitum energy intake, motivation and tolerance to acute physical exercise in healthy adults: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-24	Faculdade de Nutrição - Universidade Federal de Alagoas	Faculdade de Nutrição - Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-6zm7yvg	<NULL>	Age between 19 and 30 years; both sexes, body mass index between 18.5 and 24.9 kg/m²; classified as irregularly active or active according to the criteria of the International Physical Activity Questionnaire short version; stable weight for at least 1 month; willing to comply with the schedule proposed by the research	The need for medical clearance to exercise according to the American College of Sports Medicine&apos;s Exercise pre-participation health screening questionnaire for exercise professionals; self-reported diagnosis of cardiorespiratory problems; chronic use of any medication (eg. : anti-diabetics, anti-hypertensives, anti-depressants, anti-retrovirals, immunosuppressants); altered fasting blood glucose, blood pressure or lipid profile; condition that makes it impossible to perform anthropometry, measurement of energy expenditure components or ergometric tests; individuals who are unable to consume the diet provided and/or have any food intolerances/allergies/restrictions; disordered eating behavior assessed using the Three-Factor Eating Questionnaire-18 tool; smokers; pregnant and breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-93bscrv	Effects of Mechanical Stimulation using different Sialogogues on the evaluation of Salivary Flow in adults	Recruiting	Intervention	2025-02-11	<NULL>	<NULL>	7819	Effects of Mechanical Stimulation using different Sialogogues on the assessment of Salivary Flow in adults	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-26	Faculdade de Ciências de Saúde da Universidade de Brasília	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-93bscrv	<NULL>	For Group 1, participants must be over 18 years old, of both sexes, in good systemic health, and without comorbidities such as hypertension, diabetes mellitus, or immunosuppressive diseases. They must be non-smokers, and alcohol consumption should be socially moderate. Additionally, alcohol consumption is not allowed within 24 hours prior to the collection. For Group 2, participants must be over 18 years old and exhibit symptoms of xerostomia	For Group 1, individuals who are using medications known to negatively affect salivary flow or induce xerostomia, including antihistamines, antidepressants, and anxiolytics, will be excluded. Smokers and heavy drinkers will also be excluded, as well as participants who consumed alcohol within 24 hours before the sialometry session. For Group 2, participants who do not present symptoms of xerostomia will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-72dqtm	Effects of mechanical vibration generated on a vibratory platform in patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2019-08-14	<NULL>	<NULL>	2873	"Effects of mechanical vibration on oscillating/vibration platform  in patients with
Chronic obstructive pulmonary disease"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-04	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-72dqtm	<NULL>	Patients of both sexes, under follow-up at Serviço de Pneumologia do HUPE, diagnosed with COPD based on the criteria established by GOLD; patients with stable disease; with Forced Expiratory Volume in the 1st Second less than 50%; independent patients; signed by the Free and Informed Consent Form.	Patients with exacerbation for less than 3 months; patients with labyrinthitis; patients with osteoporosis reported; patients with other respiratory diseases; patients using pacemaker; patients with previous history of fractures or other orthopedic diseases submitted to surgeries with implantation of metallic material; patients with peripheral vascular disease or thromboembolism; patients smoker or severe alcoholic; patients with decompensated cardiovascular disease; patients with aneurysm; patients with previous vitreous hemorrhage; patients in malnutrition; postoperative patients; patients with neurological disease that causes &quot;fear&quot; of movements on the vibrating platform; severe or incapacitating clinical illness, at the discretion of the investigator.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-2hsd46j	Effects of Medical painting therapy in patients with Essential tremor	Terminated	Intervention	2023-05-29	<NULL>	<NULL>	6112	Evaluation of the effects of Medical painting therapy Liane Collot d&apos;Herbois in patients with Essential tremor	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2hsd46j	<NULL>	Min age 18 years; both genders; diagnosed with Essential Tremor; without cognitive impairment; authorized signature of the free and consent form	Schizophrenia; other psychotic disorders; using antipsychotic medications; ex-patient from Medical Painting Therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-3j6xjy	Effects of medical telephone discussion on the endocrinology referral list	Recruiting	Intervention	2016-04-12	<NULL>	<NULL>	797	Evaluation of the effectivity of teleconsultations for improving the quality of the referrals from primary care to specialized care of patients nonresidents in Porto Alegre with endocrine health conditions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-02	Programa de Pesquisa e Pós-Graduação em Epidemiologia / Universidade Federal do Rio Grande do Sul	Secretaria Estadual da Saúde do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3j6xjy	<NULL>	Referrals from patients from counties with at least 5 endocrinology referrals waiting appointment for endocrinology specialty. Referrals from adult patients (more than 18 years old). Referrals from the primary care. Referrals which the reason for referral is included in one of the referring protocols (Diabetes Mellitus; Hypothyroidism; Hyperthyroidism; Goiter; Thyroid nodule; Obesity).	Referrals from patients from counties with more than one hundred endocrinology referrals waiting appointment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-8gyj2fc	Effects of meditation and physical exercise on stress levels	Recruiting	Intervention	2022-11-07	<NULL>	<NULL>	5707	Effects of meditation and functional training on stress levels and its association with neurobehavioral, autonomic and vascular functions in doctoral students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-22	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8gyj2fc	<NULL>	Regular students in academic doctoral courses of both sexes	Doctoral students who are taking special courses (isolated courses) and doctoral programs in the professional modality. Students with a diagnosis that prevents them from participating in the research will also be excluded (people with severe uncorrected hearing and/or visual impairment), who are using some type of pharmacological medication that may influence the evaluated variables (for example, antidepressants, anxiolytics, corticosteroids) , statins, beta-blockers, anti-inflammatory drugs, stimulants, etc.), students who do not have access to the internet and/or electronic devices (cell phone, computer, tablet, etc.), with a history of some type of mental disorder, cardiovascular disease, diabetes mellitus, syndrome of Raynaud`s, who answered “YES” to one or more questions on the Physical Activity Readiness Questionnaire (PAR-Q), who participated regularly or had attended physical exercise and/or meditation programs in the last three months, smokers and participants of the research that do not carry out 75% of the planned interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-8hdfjdn	Effects of Meditation on sleep quality of medical students	Recruiting	Intervention	2024-01-14	<NULL>	<NULL>	6727	Effects of a Meditation Program on the sleep quality of medicine course students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-8hdfjdn	<NULL>	"Interest in participating in the study; age between 18 and 59 years old; both genders; being duly registered in the
Medicine course at Passo Fundo faculties, from the 1st to 12th phase of the course"	Have participated in another course or workshop on meditation in the last 4 weeks in addition to the invitation to study;  being an active practitioner of meditation, yoga, tai-chi, qui-gong (at least 6 months before the start of the study); previous medical diagnosis of cognitive, language or communication deficits; alcohol dependence and other chemical substances; previous medical diagnosis of a disorder with risk of suicide or attempt of previous suicide; previous medical diagnosis of post-traumatic stress disorder; previous medical diagnosis of  depressive disorder currently untreated; previous medical diagnosis of schizophrenia or delusional/hallucinatory disorders; revious medical diagnosis of social anxiety (difficulty being in a classroom)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-8pqp4q	Effects of meditation practice on stress reduction in teachers	Recruitment completed	Intervention	2020-04-14	<NULL>	<NULL>	3746	Randomized Controlled Trial of the effects of meditation practice on stress reduction in teachers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8pqp4q	<NULL>	To be an active teacher of Ensino Fundamental II at São Paulo City	Under 21 years old and over 65 years old; Uncontrolled chronic diseases; regular meditation practice and similar techniques, such as yoga and tai chi chuan; use of prescription drugs without medical supervision; presence of sleep disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-6c9qj8y	Effects of meetings to promote healthy eating habits on the body perception that adolescents have of themselves in a public school in the city of São Paulo/SP	Recruiting	Intervention	2024-02-26	<NULL>	<NULL>	6804	Effects of food and nutrition education actions on the nutritional self-perception of adolescents from a public school in the city of São Paulo/SP	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-02	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6c9qj8y	<NULL>	Students of both sexes; aged between 14 and 19 years old; regularly enrolled in High School at ETEC-GV	Adolescents with non-communicable chronic diseases; diagnosis of eating disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-8pjqh2	Effects of Melatonin on clinical manifestations, inflammation and sleep quality in patients with Rheumatoid Arthritis	Recruitment completed	Intervention	2018-02-23	<NULL>	<NULL>	1652	A randomized prospective study on the effects of chronic administration of Melatonin on clinical manifestations, oxidative stress, inflammation, and sleep-wake rhythm in patients with Rheumatoid Arthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-18	Faculdade de Medicina da Universidade Federal do Ceará	Hospital Geral Dr. César Cals	https://ensaiosclinicos.gov.br/rg/RBR-8pjqh2	<NULL>	Have a diagnosis of rheumatoid arthritis confirmed by a rheumatologist, according to international criteria; being with the disease activity stable and not having undergone a change of therapeutic regimen in the three months prior to inclusion; not have been hospitalized for eight weeks prior to inclusion; not to abuse alcohol or illicit drugs; be over 18 years of age, have no diagnosis of cardiac, hepatic or renal insufficiency, have signed the free and informed consent form. Pregnant or breastfeeding women were not included either.	Patients without a conclusive diagnosis for rheumatoid arthritis; children under 18 years of age; unstable disease or in the process of therapeutic adequacy; hospital admission history in the eight weeks prior to inclusion; history of abusive use of alcohol or illicit drugs; refusal to participate in the study; pregnant or nursing women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-557ngk	Effects of Melatonin supplementation and Physical Exercise practice on aged individuasl with Muscular Weakness	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3456	Effects of Melatonin supplementation on Sarcopenic aged individuals submitted to a Physical Exercise program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-557ngk	<NULL>	Age between 55 and 80 years; both genders; diagnosis of sarcopenia	Present an orthopedic disorder that contraindicates physical activities; cognitive disorder that makes it difficult to orient the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-8nqsfsn	Effects of Melatonin Supplementation on Sleep Quality in Patients with Advanced Glaucoma	Recruitment completed	Intervention	2025-04-27	<NULL>	<NULL>	7957	Randomized Clinical Trial: Effects of Melatonin Supplementation on Sleep Quality in Patients with Advanced Glaucoma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-04	Universidade Federal de Sao Paulo ( UNIFESP)	Associação Fundo de Incentivo à Pesquisa ( AFIP)	https://ensaiosclinicos.gov.br/rg/RBR-8nqsfsn	<NULL>	Patients over 40 years of age and under 80 years of age; both genders; diagnosed with glaucoma (determined by at least 2 criteria: optic nerve excavation on retinography examination, greater than 0.6; typical defect in perimetry; localized damage to the nerve fiber layer); informed consent form granted	Patients with a history of depression; intraocular surgeries (except cataract surgery); ocular trauma; who work at night; systemic medications for sleep disorders; or intolerance to the use of medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-4gxbszn	Effects of Mentholated Popsicle on vasopressin, thirst and discomfort	Recruitment completed	Intervention	2022-08-24	<NULL>	<NULL>	5578	Effects of Mentholated Popsicle on vasopressin, osmolarity, intensity, thirst discomfort and oral dehydration: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-20	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-4gxbszn	<NULL>	Age between 18 and 50 years; male, not be smoker; not be alcoholic; daily fluid intake habits: minimum of 2 liters of water / day	Kidney failure; systemic arterial hypertension; diabetes; hydroelectrolytic disorders such as vomiting and diarrhea; women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-6crdyx	Effects of metformin at high pressure and mild hypothyroidism	Recruitment completed	Intervention	2015-07-13	<NULL>	<NULL>	543	Non antihyperglycemic effects of metformin on blood pressure and subclinical hypothyroidism	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-14	Hospital de Clínicas de Porto Alegre - UFRGS	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-6crdyx	<NULL>	Volunteers of both sexes; aged between 18 and 65; with TSH greater than the upper limit of normal for the method in two steps, the first by any method and the second measured by chemiluminescence accompanied by free T4 levels within normal limits.	Previous diagnosis of type 2 diabetes; use of levothyroxine; contraindications to the use of metformin; known abnormal liver function; heart failure NYHA III-IV despite optimal drug therapy; serious mental illness; any terminally ill; malignancy not cured or in treatment; contrast studies in the last three months; use of medications known to interfere with thyroid function.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-67wxdw8	Effects of metformin during swimmer training performance	Data analysis completed	Intervention	2021-05-11	<NULL>	<NULL>	4638	Effects of metformin on training quality, performance and metabolic participation of swimmers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-15	Escola de Educação Física e Esporte de Ribeirão Preto	Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-67wxdw8	<NULL>	The inclusion criteria include that the participant have experience in the sport for three years or more, participate regularly in competitions at the state or national level, have been training regularly for the past 2 years and present a medical certificate	Participants will be excluded who have type I or II diabetes mellitus, have some physical limitation, have kidney and / or liver problems or have pre-availability for such and have gastric discomfort after ingestion of the capsule.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-47tvky	Effects of metformin on brown fat of patientes with Polycystic Ovary Syndrome	Recruiting	Intervention	2017-07-04	<NULL>	<NULL>	1276	Effects of metformin on levels irisin and distribution of brown fat in women with Polycystic Ovary Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-47tvky	<NULL>	Premenopausal women diagnosed with polycystic ovary syndrome using the Rotterdam criteria (2003)	Use of antiandrogen medication in the last six months or hormones, including hormonal contraceptives, or metformin in the last two months. Obesity grade II or higher, defined as body mass index greater than 35 kg / m2. Pregnancy, postpartum and lactation. Diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-3ypm3f	Effects of mild versus moderate training in patients with heart failure.	not yet recruiting	Intervention	2011-07-18	<NULL>	<NULL>	17	Comparison of the effects of mild versus moderate aerobic training on the inflammatory markers, on oxidative stress and quality of life, in patients with chronic heart failure – a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-09-01	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG	Ambulatório de Insuficiência Cardíaca - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-3ypm3f	<NULL>	"Patients with diagnosis of heart failure for at least six months, clinically stable for at least two months before this study. 
Left ventricular ejection fraction &lt; 45%.
Aging between 25 and 59 years old.
Body mass index (BMI) &lt; 30 kg/m2.
Stage C of the guidelines from the American College of Cardiology and American Heart Association (2005).
Classes I to III from the New York Heart Association (NYHA).
Sedentary, as defined by American College of Sports Medicine (2007)."	"User of cardiac pacemaker.
Inflammatory diseases in acute phase;
Renal insufficiency.
Orthopedic or neurological impairments which limit the exercise performance.
History of respiratory disease, unstable angina, uncontrolled arrhythmias or peripheral obstructive arterial disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6c9njc	Effects of Mindfulness on impulsivity of people with Substance Use Disorders	Recruitment completed	Intervention	2019-03-11	<NULL>	<NULL>	6403	Effects of MBRP on impulsivity of people with alcohol use	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-25	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-6c9njc	<NULL>	Both genders; having received or not a diagnosis of Alcohol Use Disorder, who have been undergoing hospitalized treatment at the services participating in the research for at least 15 days; who have been abstinent for the last 15 days (except for tobacco and caffeine); who are interested in participating in the research.	Were diagnosed with severe neurological or psychiatric diseases; Had suicidal ideation or posed a risk to themselves and others; Did not speak Portuguese; psychotic disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-63qsqx	Effects of Mindfulness on the well-being of college students	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2949	Effects of MBI (Mindfulness-Based Intervention) on the well-being of college students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-15	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-63qsqx	<NULL>	Men and women over 18 years of age; who are enrolled in an undergraduate or postgraduate course at a Brazilian university; who are interested in the objectives of the study; and who agree to participate in the research.	Uncompensated psychotic disorder; severe cognitive impairment; and / or have already completed a group of mindfulness.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-6wf5hpt	Effects of Mirror Therapy on motor function of the paretic upper limb in chronic stroke	Data analysis completed	Intervention	2024-10-15	<NULL>	<NULL>	7432	Effects of Mirror Therapy on the motor function of the paretic upper limb of individuals affected by Stroke in the chronic phase	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Centro Educacional de Lavras	Centro Educacional de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-6wf5hpt	<NULL>	Age 18 years or older; clinical diagnosis of unilateral ischemic or hemorrhagic stroke;at least six months post-stroke; presenting with upper limb hemiparesis; no severe spasticity in the paretic upper limb (Modified Ashworth Scale score less than 4); no significant cognitive impairments (Mini-Mental State Examination score of 24 or higher for those with formal education, and 14 or higher for illiterate individuals);individuals with no visual impairments that would hinder their ability to observe movements in the mirror	Participants who missed more than 30% of Mirror Therapy sessions were excluded; individuals already receiving physiotherapy for their paretic upper limb were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-2gkc7t	Effects of mirror therapy on the recovery of hand movements with partial loss of motor function in patients who suffered a stroke	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	2337	Effects of mirror therapy on the recovery of motor function from the paretic hand in  patients after stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Centro Universitário Maurício de Nassau	Centro Universitário Maurício de Nassau	https://ensaiosclinicos.gov.br/rg/RBR-2gkc7t	<NULL>	Clinical diagnosis of Cerebral Vascular Accident; presenting kinetic-functional hemiparesis diagnosis; be between 40 and 70 years old; have sequelae time between 3 and 12 months; have preserved cognitive function.	Present another associated neurological disease; have sequelae of rheumatic, orthopedic, or vascular dysfunctions in the paretic hand; three consecutive sessions during the execution of the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-34fr3y	Effects of mobile application use on adherence to treatment after Angioplasty.	Recruiting	Intervention	2017-10-16	<NULL>	<NULL>	1419	Effects of use mobile application on adherence to treatment after Percutaneous Coronary Intervention: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade do Vale do Rio dos Sinos - UNISINOS	Associação Pró-Ensino em Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-34fr3y	<NULL>	Have performed percutaneous coronary intervention with stent implantation (regardless of the number of stents and type) for treatment of stable coronary artery disease or for acute event; own smartphone (Android or iOS platform); of both sexes; be over 40 years old.	Patients with motor and / or neurological difficulty to use the smartphone; inability to respond to the questionnaire due to motor and / or neurological difficulty.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-4k9m6g	Effects of mobilization and muscle strengthening of neck in neck pain	Not yet recruiting	Intervention	2016-06-24	<NULL>	<NULL>	899	Effects of association between Mobilization and Segmental Stabilization Cervical in function, range of motion, and strenght of patients with Chronic Neck Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4k9m6g	<NULL>	chronic neck pain and cervical radiculopathy; aged 30 to 50 years; and patients signed a free and clarified	patients with cervical spine surgery; concomitant treatment for neck pain; neuromuscular disorders; neurological diseases; pregnant patients; smokers and patients with cognitive problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-6bg7xkk	Effects of moderate exercise associated with exposure to unpleasant images on anxiety and anger in women	Recruiting	Intervention	2021-06-02	<NULL>	<NULL>	6309	Comparison of the Acute Effects of Continuous Aerobic Exercise of moderate-intensity associated with Exposure to Unpleasant Stimuli on Anxiety and Anger levels in young women	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6bg7xkk	<NULL>	Woman; Aged between 18 and 40 years old	Presence diseases, dysfunctions and/or limitations that that prevents doing physical activity; to have contraindications for physical activity; abuse or addiction to alcohol and/or tobacco; to be in the menstrual period; not answering any study question; discontinuity of testing; to be illiterate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-2zd2rgy	Effects of moderate training and high-intensity training on measures of metabolism and liver health in adults	Not yet recruiting	Intervention	2022-11-08	<NULL>	<NULL>	5711	Effects of Continuous Moderate Intensity Training and High Intensity Interval Training on physiological and pathological makers of Metabolic Syndrome and hepatic health in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto de Pesquisa da Capacitação Física do Exército	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2zd2rgy	<NULL>	Male sex; military personnel from the Army Physical Training Center and/or from the 1st Guards Battalion; submitted to a weekly nutritional control; and signature on the free and informed consent term.	military personnel who have undergone any type of abdominal surgery, or with any type of osteoarticular or musculoskeletal injury and other clinical conditions that prevent them from performing any of the assessments, which limit movements or who are undergoing restrictive medical treatments; Military personnel who are using any substance or drug capable of altering the test results; Military personnel who are unable to attend all stages of data collection or who are considered physically unfit by a previous medical assessment, especially cardiopulmonary health assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-592yyp	Effects of motor training in elderly clinical responses	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1614	Effects of proprioceptive training on the responses and sensorial and functional responses of elderly people with peripheral diabetic neuropathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-10	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-592yyp	<NULL>	Age at or above 60 years, insufficiently active, absence of cognitive deficit, absence of impairment due to cardiovascular diseases limiting to exercise, absence of severely impaired visual or auditory acuity, absence of cutaneous lesions in the feet and amputations, independent walking and locomotion without auxiliary devices and absence of diagnosis of neurological disease that affects gait pattern.	Elderly persons attending another proprioceptive rehabilitation program during training or in the last three months, and those who participate in less than 75% of the training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-8fb7q2	Effects of Mucuna Pruriens Supplementation on muscle gain, strenth and testosterone concentration in resistance trained men	Suspended	Intervention	2020-08-13	<NULL>	<NULL>	4122	Effects of Mucuna Pruriens Supplementation on muscular hypertrophy, strength and free testosterone concentrarion in resistance trained men	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Universidade Federal de São Paulo campus Baixada Santista	Universidade Federal de São Paulo campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-8fb7q2	<NULL>	Male individuals who were 20-40 years old and practiced resistance training for at least 3 months non-interuptly.	the participants will be excluded if they take some medication, sterois and supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-2z96w6	Effects of Multicomponent Exercise on Cognition in the elderly	Not yet recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2195	Multicomponent exercise program on cognition, structure and brain function in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes- HUOL/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-2z96w6	<NULL>	Age between 60 and 75 years, with medical clearance to six months before clinical evaluation.	Body mass index equal or greater to 35; use of medication that suppresses neuroendocrine system responses; not reach the minimum of 23 points in the mini mental state exam; musculoskeletal limitations that limits the practice of physical activity; report at least one yes on response in PARQ; participate in regular physical exercise programs and dietary interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-7mz2kr	Effects of multicomponent exercise program in the group and/or  at home in community-dwelling older adults	Not yet recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3283	Effects of center and/or home-based multicomponent exercise program in community elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7mz2kr	<NULL>	60 years of age and over; not participating in an exercise program for 6 months prior to project participation	Physical restrictions to perform the tests and/or exercises; cognitive deficits based on the Mini-Mental State Examination scores adjusted by educational level; medical contraindications for participation in exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-7hs2mv	Effects of multicomponent exercises on the elderly health	Recruiting	Intervention	2020-08-06	<NULL>	<NULL>	4095	Effectiveness of a multicomponent exercise program on older adults&apos; health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Departamento de Educação Física da Universidade Federal do Paraná	Programa de Pós-Graduação em Educação Física- PPGEDF/UFPR	https://ensaiosclinicos.gov.br/rg/RBR-7hs2mv	<NULL>	Will be included in this study men and women aged from 60 years, with independent mobility (without using auxiliary devices), who are able to practice physical activities and who are not regularly participating in a systematic physical exercise program.	Will be excluded from the study, older adults with disabling osteoarticular diseases of the lower limbs; those  who have insufficient cognitive function to understand the tests and exercises; who have undergone orthopedic surgery in the six months preceding the study; and that present some absolute contraindication to physical exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-10v99xgj	Effects of Multicomponent Physical Exercise and Auriculotherapy in the elderly	Not yet recruiting	Intervention	2024-05-13	<NULL>	<NULL>	7002	Effects of a Physical Exercise protocol Multicomponent and Auriculotherapy in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-13	Universidade Comunitária da Região de Chapecó	Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-10v99xgj	<NULL>	Physiotherapeutic and/or medical diagnosis of chronic low back pain; (2) age group between 60 and 75 years old and of both sexes; preserved cognitive, assessed by the Mini-exam Mental State; chronic low back pain, defined as a complaint of pain in the lumbar region below the twelfth thoracic vertebra, with or without irradiation, lasting more than six months and with a moderate to intense degree of intensity, tested by the Visual Analogue Pain Scale	Missing two consecutive sessions of intervention or three interspersed; (2) carrying out acupuncture treatment in the last six months; undergoing physiotherapeutic treatment in the last three months; have neurological injuries or disorders that compromise walking and execution of exercises; have tumors or are undergoing cancer treatment; present bone or marrow infections and ankylosing spondylitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-5ydpb34	Effects of multicomponent training on functional capacity, muscle performance and body composition of institutionalized older adults	Recruitment completed	Intervention	2021-02-03	<NULL>	<NULL>	4504	Effects of multicomponent training on functional capacity, muscle performance and body composition of institutionalized older adults: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Universidade Federal do Amazonas	Faculdade de Medicina da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5ydpb34	<NULL>	Age between  60 to 80 years old (minimum of 60 and a maximum of 80 yrs);Being residents at the  Doutor Thomas Foundation;Being able to walk without or with aid equipment (walking stick or walker);Being able to participate in the functional tests and the intervention program with a frequency of 3 times a week for 12 weeks;	Having uncontrolled cardiovascular diseases; osteomioarticular dysfunction;endocrine malfunction that prevents them from participating in the assessment tests and the intervention program;Using a wheelchair or being bedridden;Present cognitive impairments indicated by the Mini mental test;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-1045xxpm	Effects of multidisciplinary educational intervention on the level of knowledge, quality of Life and self-care of elderly diabetics: a randomized clinical trial	Recruitment completed	Intervention	2024-07-30	<NULL>	<NULL>	7168	Effects of multidisciplinary educational intervention on the level of knowledge, quality of Life and self-care of elderly people with Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-02	Faculdade de Medicina de Marília (FAMEMA)	Faculdade de Medicina de Marília (FAMEMA)	https://ensaiosclinicos.gov.br/rg/RBR-1045xxpm	<NULL>	Have been diagnosed with Diabetes Mellitus for more than six months; be aged 60 or over; agree to participate in the study and sign the Consent Form	Cognitive and intellectual limitations that make it impossible to respond to the study instruments; being bedridden or unable to move around to participate in the study; unjustified absence in intervention activities; change of city, illness or death during the study; withdrawal from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8vc895f	Effects of multimodal prehabilitation in gastrointestinal oncological surgeries	Recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8706	Impacts of in-person and hybrid models of Multimodal Prehabilitation in cancer patients undergoing gastrointestinal tract surgeries a pragmatic clinical trial	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Adult patients of both sexes; aged 18 years or older; indication for elective thoracoabdominal surgery for diagnosis or treatment of gastrointestinal tract neoplasms such as esophagectomy, gastrectomy, duodenopancreatectomy or colorectal procedure; acceptance to participate in the research by signing the Informed Consent Form	Significant cognitive deficits or dementia that prevent understanding of instructions as determined by clinical assessment or validated test; medical contraindication to physical activity; cardiopulmonary, musculoskeletal, or neurological conditions that preclude exercise, such as unstable angina, decompensated heart failure, high risk of falls, or active fractures; prescription of enteral or parenteral nutrition in the preoperative period; active substance use disorders that compromise adherence to the protocol; decompensated comorbidities such as diabetes mellitus, renal or hepatic insufficiency, and uncontrolled hypertension; severe functional limitations such as prolonged bed rest, continuous use of oxygen therapy, or mechanical assistance devices; lack of access to an internet-enabled device or severe limitations in digital literacy without family support; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-5v8vtr4	Effects of multimodal training on cardiovascular risk in hypertensive elderly people	Recruitment completed	Intervention	2024-12-05	<NULL>	<NULL>	7575	Effects of Aerobic training on cardiorenal adaptations and Cardiac autonomic modulation in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-5v8vtr4	<NULL>	Be aged ≥60 years. Be normotensive or controlled hypertensive. Be sedentary. Have the cognitive ability to understand the research process. Sign the free and informed consent form	Attendance at training sessions below 85%. Do not respond to questionnaires. Present systolic blood pressure greater than or equal to 160 mmHg and diastolic blood pressure greater than or equal to 100 mmHg recurrently in 3 training sessions. Not using your antihypertensive medication regularly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-6k7mrf	Effects of Muscle Energy Technique on Neck Range of Motion and Head Position	Recruitment completed	Intervention	2013-07-02	<NULL>	<NULL>	201	Effects of Muscle Energy Technique on Range of Motion and Cervical Spine Position Sense of Subjects with Chronic Neck Pain	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-12-18	Faculdade Estácio de Sá de Vitória	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6k7mrf	<NULL>	Subjects presenting neck pain for more than three months.	Trauma. Pregnancy. Peripheral neurological disease. Vestibular dysfunction. Systemic neurological disease. Congenital abnormalities. Pain during manipulative procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-225ksb	Effects of muscle fatigue on knee sensitivity	Data analysis completed	Intervention	2018-02-21	<NULL>	<NULL>	1648	The influence of femoral quadriceps muscle fatigue on joint knee proprioception	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Universidade São Judas Tadeu	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-225ksb	<NULL>	Healthy volunteers, classified as active, according to the International Physical Activity Questionnaire, without previous injuries in the lower limbs.	To present pathologies in incapacitating levels; having a diagnosis of fibromyalgia or rheumatoid arthritis; participation in a neuromuscular strengthening or exercise program or other (non-pharmacological) treatment for the knee in the last six months; prosthesis or any other surgery on the hip and knee joints; decompensated heart diseases; hearing or visual impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-8chg6q	Effects of muscle stretching on pain	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1797	An exercise program for Postural Correction and Pain symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8chg6q	<NULL>	Nursing professional; officer of a polyclinic in the city of niterói-rj; ages between 18 and 60 years; to present some postural deviation; do not practice any physical activity oriented during the period of participation in the research	Inability to perform tests and stretching exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7mwjzwb	Effects of Muscle Trigger Point Dry Needling Therapy in Patients with Jaw Pain	Data analysis completed	Intervention	2021-07-14	<NULL>	<NULL>	4788	Effects of Myofascial Trigger Point Dry Needling Therapy in Patients with Temporomandibular Disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade Federal de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7mwjzwb	<NULL>	Temporomandibular disorder; myofascial trigger point in the masseter muscle; age between 18 and 40 years; both genders.	Pregnant women; vascular diseases; blood dyscrasias; trigeminal neuralgia; fibromyalgia; history of odontogenic infection in the last 30 days; current or past history of neoplasia or radiotherapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:40
RBR-8shb3h	Effects of Muscular Massage with Instruments on the operation of the heart of young women practicing weight training	Not yet recruiting	Intervention	2018-05-31	<NULL>	<NULL>	1863	Effects of Instrumental Myofascial Release on cardiac autonomic modulation in young women practicing weight training	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Centro Universitário de Formiga - Minas Gerais	Centro Universitário de Formiga - Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8shb3h	<NULL>	40 young women; age between 18 and 24 years; exercise bodybuilding at least three times a week for a minimum of six uninterrupted months; present vital signs such as blood pressure, heart rate, oxygen saturation and respiratory rate within the normality patterns at the time of data collection; resting heart rate between 50 and 80 beats per minute (bpm); agree and sign the Informed Consent Form	Chronic obstructive pulmonary disease; Diabetes Mellitus; Arterial hypertension; Thyroid diseases; Heart diseases; patients with pacemakers; users of medications Diuretics and Beta-blockers; obese individuals; dermatological problems; skin lesions; edema; changes in blood coagulation; vascular hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-7d6qr5f	Effects of muscular strength, balance, flexibility, agility and coordination exercises and calcium vitamin ingestion on the function of the muscle / bone of older wonen with osteoporosis	Recruiting	Intervention	2021-11-09	<NULL>	<NULL>	5029	Effects of multicomponent exercise and vitamin D and calcium supplementation on musculoskeletal function and risk of falls in older women with osteoporosis: randomized controlled clinical trial (VITADEX study)	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-09-20	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7d6qr5f	<NULL>	Elderly women; 65 years of age or above on the day of the initial assessments; resident in Curitiba-PR-Brazil; with a diagnosis of osteoporosis by dual energy x-ray (DEXA); able to walk independently a 8 meter flat course, with or without any assistive equipment; presenting a cognitive score in accordance with the Mini Mental state (score 24) regarding the presence or absence of prior formal schooling; not having neurological diseases and/or orthopedic traumas that may prevent the evaluation and exercises execution; not having severe deficiencies (cardiac, respiratory, hepatic, renal, and decompensated hypertension Blood pressure (140 and 90 mmHg); not having any neurologic or trauma-orthopedic diseases with fixations or prostheses with metallic or non-metallic implants, which may prevent the performance of the proposed evaluations or exercises; not having had prior history of upper extremities and Lower Extremity and or spine fracture in the last 4 months or that may impair their performance in the proposed evaluations and  exercises; Visual assessment by the Snellen card presenting (score 20 and 70 unilateral), in case of visual impairment, an adequate corrective instrument should be used (glasses or lenses); not having been involved in any regular resistance exercise program in the last 6 months.	Previous history of fractures of the upper and lower limbs and or spine in the last 4 months; presenting metabolic instability or decompensated cardiovascular disease; having inflammatory and or autoimmune diseases, acute or terminal disease; cancer. Present neurological diseases; osteomalacia; presenting unstable or exercise-induced angina pectoris or myocardial ischemia; presenting type 1 diabetes mellitus; presenting previous diagnosis of: hypercalciuria, hyperparathyroidism, desabsorptive syndromes; using anabolic steroids (for example: synthetic testosterone, Growth hormone (GH);  growth factor I (IGF-I) taking part in a regular physical training program; using antiretrovirals and/or anticonvulsants and/or immunosuppressant drugs and/or corticosteroids; making use of current daily or last year alcohol intake above 25g/day; having severe deficiencies (cardiac, respiratory, hepatic, renal, and decompensated hypertension  above 140 and 90 mmHg); previous diagnosis of diseases such as: heart valve moderate stenosis, chronic obstructive lung disease (COLD) with Forced expiratory volume (FEV-1) lower 50% previously diagnosed, hypothyroidism with altered levels of thyroid stimulating hormone (TSH) or  free thyroxine (T4)T4; hypo or hyper cortisolism; chronic kidney disease with glomerular filtration rate estimated below 30ml/min.1.73m2 according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI).equation; infectious-contagious disease; human immunodeficiency vírus (HIV), hepatitis, and diabetes mellitus with lesions in the target organ of any gravity and difficult to control clinically; using two or more hypoglycemic drugs; insulin therapy or with glycated hemoglobin (HbG) higher 8.5%; patients who  experienced clinical complications requiring hospitalization or an emergency unit within the 90 days preceding the evaluations of the study protocol or who were bedridden for the same period, and patients with the following conditions: using medications that could alter body composition or physical performance, any clinically decompensated chronic disease, neurological disease, except for osteoporosis, pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-8s22sh8	Effects of music on attention of children with and without Attention deficit with hyperactivity disorder (ADHD)	Recruiting	Intervention	2021-04-05	<NULL>	<NULL>	4600	Effects of music on attention of children with and without Attention deficit with hyperactivity disorder (ADHD)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-15	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-8s22sh8	<NULL>	Children aged 10 to 12 years and male (23 with ADHD; 23 without ADHD). For the group with ADHD, children should have the diagnosis confirmed by the criteria established by the DSM-5 and the Brazilian version of schedule for affective disorders and schizophrenia for school-age Children/Present and Life time Version (KSADS-PL) and present percentile equal to or greater than 70 in raven&apos;s intelligence test. Children without ADHD should have less than 2 ADHD or opposition symptoms identified by SNAP-IV or score below 70 on the ADHD or CBCL scales. Children should also not have a history of school failure or who are under pedagogical accompaniment.	"We will exclude children with a history or current evidence of psychosis, severe autism,
brain disease, or any genetic or medical disease related to behaviours that may mimetize or influence ADHD, and discontinuity of the
treatment for at least three months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-8jnxtm	Effects of music on cardiovascular system	Not yet recruiting	Intervention	2013-07-08	<NULL>	<NULL>	207	Effect of different hearing stimuli on cardiac autonomic regulation	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-30	Faculdade de Filosofia e Ciências, UNESP/Marília	Faculdade de Ciências e Tecnologia, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-8jnxtm	<NULL>	Healthy subjects with no experience with classical dance and musical instrument lessons.	Disorders of auditory sensitivity, cardiorespiratory disorders, neurological and other impairments that prevent the subject known to perform procedures, treatment with drugs that influence cardiac autonomic regulation, practice-classical dance for at least one year, participation in classes of any musical instrument for at least one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-65mfym6	Effects of music therapy in patients with mechanical ventilation	Recruitment completed	Intervention	2024-09-12	<NULL>	<NULL>	7337	Effects of music therapy on delirium and ventilatory weaning of patients on mechanical ventilation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital e Maternidade Galileo	Hospital e Maternidade Galileo	https://ensaiosclinicos.gov.br/rg/RBR-65mfym6	<NULL>	Individuals over 18 years old and under 80 years old; of both sexes; patients on mechanical ventilation for more than 48 hours associated with the use of sedative drugs; signing the Free and Informed Consent Form by the responsible family member	Individuals with an underlying disease that may interfere with the interpretation of their level of consciousness, such as previous cerebrovascular accidents; any previously diagnosed dementia; individuals undergoing brain surgery; patients with acute kidney disease; patients with hearing deficit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-3x7gz8	Effects of Music Yherapy on the heart rhythm of mothers of infants hospitalized in Neonatal ICU	Recruitment completed	Intervention	2018-01-17	<NULL>	<NULL>	1572	&quot;Influence of the Music Therapy Intervention on the Cardiac Autonomic Modulation in mothers in the Neonatal ICU: Randomizaed Study&quot;	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-26	Universidade Federal de Goiás	Hospital e Maternidade Dona Íris	https://ensaiosclinicos.gov.br/rg/RBR-3x7gz8	<NULL>	Mothers who are with their newborn baby hospitalized in the ICU of Dona Iris Hospital and Maternity; aged between eighteen and forty years.	"Cognitive impairment and / or hearing impairment that impedes understanding of the assessments and questionnaires involved;  Uncontrolled systemic diseases, such as diabetes mellitus, systemic arterial hypertension, and thyroid dysfunction reported by the participant; Electrocardiogram change;
use of beta-blocker medications reported by the participant; continued use of illicit drugs and / or alcohol reported by the participant; use of antidepressant informed by the participant; in psychotherapeutic care informed by the participant"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-7vwsj9	Effects of myofascial realese time with baton over the neuromuscular performance of elbow flexors	Recruitment completed	Intervention	2018-07-20	<NULL>	<NULL>	2052	Effects of different magnitudes of strength applied in massage on performance and neuromuscular activation in elbow flexors	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade de Brasilia -Faculdade de Educação Fisica	Universidade de Brasilia -Faculdade de Educação Fisica	https://ensaiosclinicos.gov.br/rg/RBR-7vwsj9	<NULL>	Healthy young people; male; age between 18 and 30 years;Physically active according to the IPAQ;	With osteomioarticular commitment of upper limbs; users of medications that may affect muscular function;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5xpg6j	Effects of myofascial release and stretching  on ankle mobility on healthy runners	Recruitment completed	Intervention	2019-03-26	<NULL>	<NULL>	2542	Effects of myofascial release and static stretching on ankle dorsiflexion range of motion in healthy runners: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-18	Departamento de Ortopedia e Traumatologia da Universidade Federal de São Paulo	Thiago Costa Buran	https://ensaiosclinicos.gov.br/rg/RBR-5xpg6j	<NULL>	Healthy runners both male and female; pratice running minimum 2 times per week; age between 18 and 45 years old; no history of trunk or lower limb injury in the last 6 months.	Participants presenting pain due to one of the intervention; start some physical activity during the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-5r6pm9x	Effects of Neuromodulation associated with Treadmill gait Training on functional mobility and balance in people with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2024-08-01	<NULL>	<NULL>	7171	Effects of repetitive Trans-spinal Magnetic Stimulation associated with Treadmill gait Training on functional mobility and postural balance in people with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5r6pm9x	<NULL>	Men and women between 18 and 80 years old; people with Parkinson&apos;s Disease (PD) in Hoehn Yahr stages between 2 and 4 (moderate disease) whose primary symptom includes gait alteration; being able to walk independently for 30 meters or with a unilateral assistive device; having a Mini-Mental State Examination (MMSE) score greater than or equal to 24 for people with more than 8 years of schooling and above 20 points for illiterate people	Unstabilized psychiatric comorbidities; other neurological disorders, musculoskeletal, orthopedic, cardiovascular, and respiratory changes that may affect the ability to walk on the treadmill; labyrinthine problems; deep brain stimulation surgery or epidural stimulation of the spinal cord; uncontrolled infection or other uncontrolled pre-existing medical conditions (e.g. uncontrolled infection or other uncontrolled pre-existing medical conditions (e.g. decompensated diabetes, hypertension, symptomatic lung or heart disease); concomitant treatment with other experimental drugs; pregnant or breastfeeding women; chronic low back and lower limb pain; not walking without an aid (cane, crutch, walker) or help from another person; metal implants and cardiac pacemakers; history of neurosurgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-6w2vtp	Effects of neuromodulation in women with fibromyalgia	Recruiting	Intervention	2020-07-20	<NULL>	<NULL>	4021	Effects of neuromodulation on electroencephalographic activity in fibromyalgia patients and comparison with healthy ones	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal da Paraíba	Programa de Pós-graduação em Neurociência Cognitiva e Comportamento	https://ensaiosclinicos.gov.br/rg/RBR-6w2vtp	<NULL>	Have a diagnosis of fibromyalgia according to the criteria of the American College of Reumathology; Having been diagnosed at least three months ago; Being female; Be in the age group between 35 and 60 years old; Present a pain level above four on the visual analog scale; Sign the Free and Informed Consent Form.	Score below 24 on the Mini Mental State Examination; illiterate; have metallic implants located on the head or cochlear implants or cardiac pacemaker; being pregnant; have a history of seizure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-56jg3n	Effects of Neuromodulation on Blood Pressure of hypertenses submitted to Physical Exercise	Recruiting	Intervention	2019-03-26	<NULL>	<NULL>	3354	Effects of Neuromodulation of insular cortex on Blood Pressure of hypertenses submitted to Aerobic Exercise	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-13	Universidade Federal da Paraíba	Instituto de Educação Superior da Paraíba - IESP	https://ensaiosclinicos.gov.br/rg/RBR-56jg3n	<NULL>	Men and women aged between 18-65 years diagnosed with arterial hypertension (systolic blood pressure greater than 130 and less than 180 mmHg or diastolic greater than 85 and less than 120 mmHg) will be included.	Participants will be excluded if they present a diagnosis of resistant hypertension; history of hematological diseases; neurological diseases; peripheral vascular diseases; stroke; consume more than 30g of alcohol per day; be doing any hormone replacement therapy; have a body mass index greater than 30 kg m²; have cognitive problems that make it impossible to execute commands; present physical limitations that prevent the accomplishment of the exercise protocol; have a dissecting aneurysm and miss more than 3 sessions continuously or lack at least 30% of the stimulation and physical exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-4fw4f7	Effects of Neuromuscular Approach Techniques to reduce Knee Injury Risk Factors in amateur runners	Not yet recruiting	Intervention	2020-04-22	<NULL>	<NULL>	4676	The comparison between Neuromuscular Approaches in the Hip and in the Ankle and Foot for reducing of the Dynamic Knee Valgus in amateur runners	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-10-05	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4fw4f7	<NULL>	20 to 35 years; amateur runner beginners; Up to 1 year of practice; Maximum of 10 km per week; ; Positive Step Down Test.	The volunteers will not be able to present surgical history of the joints of the lower limb, patients with cardiorespiratory and neuromuscular disorders, or any other condition that prevents the participant from performing the proposed tasks, as well as those that do not agree with the terms for participating in the research, provided for in the Informed Consent Form - ICF	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-2z7pkq	Effects of Neuromuscular Electrical Stimulation in Patients After Stroke	Recruitment completed	Intervention	2013-08-05	<NULL>	<NULL>	3039	Effects of Neuromuscular Electrical Stimulation in Patients After Stroke: Are There Evidences for Plasticity in The Spinal Cord Circuitry Associated With Spasticity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-10	Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista &quot;Julio de Mesquita Filho&quot;	"Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista ""Julio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-2z7pkq	<NULL>	Will be included in the study, volunteers of both gender; with the diagnosis of stroke that may be hemorrhagic or ischemic, regardless of age. The stroke should have occurred for at least six months and spasticity of at least one point on the modified Ashworth scale.	Volunteers will be excluded from the study if they: Don´t have spasticity according to the Modified Ashworth Scale, present expression aphasia and comprehension (reported in medical records),cognitive and behavioral alteration (reported in medical records)and have a deficit of surface sensitivity (detected through assessment before the intervention).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-67fdcbg	Effects of Neurostimulation in children with speech and language difficulties	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7756	Transcranial Direct Current Stimulation in cognitive and language skills	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal de Sergipe	Programa de Pós-graduação em ciências aplicadas à Saúde (PPGCAS)	https://ensaiosclinicos.gov.br/rg/RBR-67fdcbg	<NULL>	Children of any sex; have a diagnosis of speech and language disorders; aged between 6 and 12 years old; inserted in the regular school environment; have degrees of understanding and collaboration compatible with carrying out the proposed intervention, that is, accept the placement of electrodes and the time required for stimulation	Children whose guardians, at some point during the research, withdraw their free and informed consent; children with epilepsy; who use metallic brain implants or hearing aids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-46tjy3	Effects of nicotine on the vision and cognition of nonsmokers	Recruiting	Intervention	2020-03-18	<NULL>	<NULL>	3628	Effects of nicotine gum on early-stage visual processing and cognition in healthy nonsmokers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-16	Universidade Federal da Paraiba	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-46tjy3	<NULL>	Participants who do not use alcohol (only moderate use ~ 5 weekly doses will be recruited; do not use of psychotropic drugs; do not have Axis I or II disorders (measured by the Mini International Neuropsychiatric Interview ~ MINI). All participants will respond to Fagerstrom Test of Nicotine Dependence (FTND), which measures whether they have nicotine dependence. Demographics will be collected by one of the responsible researchers through a brief anamnesis.	All participants who use alcohol or psychostimulant drugs, known autoimmune disease or AIDS, ophthalmic disorders such as glaucoma or retinopathies will be excluded from the study. In addition, participants who present any neuropsychiatric disorder or disease that affects visual functions will be excluded from the sample. Participants with a family history or presence of depression or anxiety will be screened for further studies. In addition, the presence of additional medications (therapeutic dose or not) will serve as an exclusion criterion since these participants will be part of an additional group, not measured in this work. All participants who for any reason no longer wish to participate in the research will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-4nr86m	Effects of Nitazoxanide Administration to Patients in the Initial Phase of COVID-19	Recruiting	Intervention	2020-08-24	<NULL>	<NULL>	4348	Effects of Early Use of Nitazoxanide in Patients with COVID-19	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-06-08	Universidade Federal do Rio de Janeiro-UFRJ	Universidade Federal do Rio de Janeiro-UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-4nr86m	<NULL>	Will be included in the study of patients of both genders who meet all of the following requirements: clinical scenario compatible with infection by the SARS-CoV-2 [Characteristic symptoms of COVID-19 (fever and / or drought and / or fatigue), beginning 1 to 3 days before inclusion in the study; age equal or superior to 18 years; willingness to receive study treatment; providing written and informed consent or the same consent signed by a family member.	Individuals who meet at least one of the following criteria will be excluded from the study: negative result of RT-PCR for SARS-COV2 collected on admission; impossibility to use oral medications; history of severe liver disease (Child Pugh C class); previous renal failure: patients undergoing dialysis; severe heart failure (NYHA 3 or 4); COPD (GOLD 3 and 4); neoplasia in the last 5 years; known autoimmune disease; individuals with known hypersensitivity to study drugs; previous treatment with the study medication during the last 30 days; clinical suspicion of tuberculosis and bacterial pneumonia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-102bc3f2	Effects of Nitrate-rich food intake in elderly individuals	Recruitment completed	Intervention	2022-09-26	<NULL>	<NULL>	7864	Effects of Nitrate-rich food consumption on physical capacity, cognitive function, mood state, and anti-inflammatory and antioxidant potential in active and sedentary older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Faculdade de Ciências da Saúde da Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-102bc3f2	<NULL>	Elderly who live in Brasilia; age between 60 and 75 years old; both sexes; elderly who accept to participate in the study	Elderly with excessive ingestion of alcoholic beverages; smokers; who use drugs that can block the reduction of nitrate and nitrite to nitric oxide (sexual hormones, antacids, proton pump inhibitors, xanthine oxidase inhibitors); drugs that can enhance nitric oxide effects (phosphodiesterase inhibitors); treatment with anticoagulants and immunosuppressive drugs; elderly who can not exercise; with malignant diseases; vegetarian; who do not like or who are advised to not consume green vegetables; who use mouthwashs; who use antibiotics until 7 days before the beginning of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:16
RBR-5rz5ch	Effects of Nitrous Oxide augmentation of the drug treatment of Depressive Disorder	Recruitment completed	Intervention	2018-12-04	<NULL>	<NULL>	2364	Effects of Nitrous Oxide augmentation of the Selective Serotonin Reuptake Inhibitors treatment of Major Depressive Disorder	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2016-06-10	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	O Instituto Nacional de Ciência e Tecnologia Translacional em Medicina	https://ensaiosclinicos.gov.br/rg/RBR-5rz5ch	<NULL>	Patients with major depressive episode according to the DSM-5 criteria, aged between 18 and 65 years, on antidepressant treatment without dose adjustment for more than 4 weeks, and who scored &gt; 17 on 17-item-Hamilton Depression Rating Scale.	Presence of relevant clinical conditions (cardiovascular diseases, severe arterial hypertension, renal insufficiency, liver disease, hypothyroidism, chronic obstructive pulmonary disease, B12 hypovitaminosis, epilepsy, pregnancy and breastfeeding); patients with relevant psychiatric comorbidities, especially substance use disorders (except caffeine and nicotine), clinical history of hypomania or mania episode induced by antidepressant medication; patients with clinical criteria of inpatient treatment; nasal septum and difficulty in breathing through the nose.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-7sstr78	Effects of Non-Invasive Brain Stimulation Associated with Voice Therapy in Participants with Voice Disorders: A randomized clinical study	Recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9105	Effect of Transcranial Direct Current Stimulation associated with Voice Therapy for Behavioral Dysphonia: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-22	Universidade Federal de Pernambuco - UFPE	<NULL>	<NULL>	<NULL>	The inclusion criteria for participation in the study are: being an adult aged between 18 and 59 years; having behavioral dysphonia without lesions; diagnosis confirmed by an otorhinolaryngologist; participants will be required to provide a medical report issued by the otorhinolaryngologist	The exclusion criteria are: volunteers with pacemakers; metallic implants in the head or cervical region; use of neuroactive medication; history of seizures; individuals undergoing speech therapy during the data collection period; and individuals with dysphonia of neurological etiology or caused by recurrent laryngopharyngeal reflux	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-48z43w9	Effects of non-invasive brain stimulation on brain and muscle activity in people with amyotrophic lateral sclerosis	Not yet recruiting	Intervention	2025-12-23	<NULL>	<NULL>	8679	Effects of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on different cortical areas on neural connectivity, cortical excitability, and muscle activity in individuals with amyotrophic lateral sclerosis: a proof-of-concept study.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Departamento de Fisioterapia	<NULL>	<NULL>	<NULL>	Individuals diagnosed with amyotrophic lateral sclerosis according to the Gold Coast criteria; age between 18 and 80 years; both sexes; adequate cognitive performance defined by a score ≥17 on the ALS Cognitive Behavioral Screen; ability to perform functional movements of the upper limbs; neurotypical individuals without a diagnosis of neurological disease; age between 18 and 80 years; both sexes; adequate cognitive performance defined by a score ≥17 on the ALS Cognitive Behavioral Screen; ability to perform functional movements of the upper limbs	Presence of neuropsychiatric disorders; history of seizures or epilepsy; history of traumatic brain injury; presence of metallic clips, pacemakers, or deep brain stimulation implants; history of neurosurgery; alcohol abuse or drug dependence	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-749zsx6	Effects of Non-Invasive Electrostimulation on students with Anxiety at an university in the Amazon: a randomized clinical trial	Not yet recruiting	Intervention	2023-10-26	<NULL>	<NULL>	6540	Effects of Non-Invasive Neuromodulation on academics with Anxiety Disorders at an university in the Amazon: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Instituto de Saúde e Biotecnologia	Instituto de Saúde e Biotecnologia	https://ensaiosclinicos.gov.br/rg/RBR-749zsx6	<NULL>	be aged between 18 and 40, of both sexes, be a university student at ISB/UFAM, have a clinical diagnosis, according to the criteria of the American Psychiatric Association 5th edition - DSM-V (2014), of anxiety disorders, and cognitive ability to understand the purpose of the research and to answer the scales and questionnaires	conditions such as uncontrolled epilepsy, individuals with metallic intracranial implants near the electrodes, pregnant women, history of brain surgery, tumor and undergoing psychotherapy at the time of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-28nhd4q	Effects of non-invasive Neuromodulation in the treatment of pain of people with advanced Cancer - a randomized controlled clinical trial focusing on an occupation of daily living	Not yet recruiting	Intervention	2025-12-11	<NULL>	<NULL>	8648	Effects of non-invasive Neuromodulation on pain management in people with advanced Cancer - randomized controlled clinical study focused on a daily life occupation	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	"Inclusion criteria: have a diagnosis of head and neck cancer (of the oral cavity, larynx
or pharynx), age between 18 and 75 years and a pain score of at least 4 points on a numerical pain scale (ranging from 0 to 10 points)"	Exclusion criteria: pregnancy and intracranial tumor and or metastasis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-2s29md	Effects of Non-Invasive Ventilation During Sleep in Patients with Chronic Obstructive Pulmonary Disease (COPD)	Data analysis completed	Observational	2020-05-25	<NULL>	<NULL>	3872	Acute effects of Noninvasive Ventilation on sleep physiology in patients with stable moderate to severe Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-05	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2s29md	<NULL>	Adult patients; over 40 years old; diagnosed with COPD by spirometric criteria, classified as moderate or severe; with stable disease characterized by the absence of exacerbation for more than 2 months; with absence of other pulmonary, cardiovascular, renal and neurological morbidities; and who signed the informed consent form	Patients who did not complete the study protocol; and who did not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-7sqj78	Effects of noninvasive mechanical ventilation in pulmonary function and functional capacity after cardiac surgery:A Randomized Controlled trial	Recruitment completed	Intervention	2015-02-10	<NULL>	<NULL>	388	Effects of noninvasive ventilation with positive pressure in the pulmonary function, functional capacity and inflammatory response after coronary artery bypass grafting: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-04	Univerdidade Federal de São Paulo	Hospital Santa Rosa	https://ensaiosclinicos.gov.br/rg/RBR-7sqj78	<NULL>	Both gender, age between 35 and 75 years; proven coronary disease by coronary angiography; Surgery elective CABG with CPB and use of the LITA; ventricular ejection fraction greater than 50%; Absence of acute pulmonary disease or chronic, patients who, after surgery, keep in spontaneous ventilation on the first day after surgery.	Inability to perform spirometry; Presence of acute or chronic lung disease; Required urgent surgery;  Chronic inflammatory disease; Kidney or liver disease; Patients using corticosteroids, acetyl salicylic acid or other anti-inflammatory drugs; Clinical or laboratory evidence of infection; Morbid obesity; Hemodynamic instability at the time of spirometry; Change the surgical technique during surgery; Death during surgery or before the fifth day after surgery; Patients who remain in prolonged mechanical ventilation for more than twelve hours; Request of the patient or legal guardian at any time during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-8jgwpr	Effects of noninvasive ventilation after cardiovascular surgery: A Randomized Clinical Trial	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	28	Effects of noninvasive mechanical ventilation on the hemodynamic and ventilatory parameters in post-cardiac surgery patients who developed hypoxemia after tracheal extubation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-01	Alessandra Preisig	Faculdade de Medicina da Universidade Federal do Rio Grande do Sul (UFRGS)	https://ensaiosclinicos.gov.br/rg/RBR-8jgwpr	<NULL>	"Postoperative cardiovascular surgery (valve replacement, thoracoabdominal aortic surgery and/or coronary artery bypass graft (CABG);
Sternal incision and pulmonary artery catheter from surgical ward 
Both genders, aged between 18 and 80 years."	"Severe chronic obstructive pulmonary disease,
Previous neurological disease and inability to understand;
More than 24 hours on mechanical ventilation;
Surgical revision for bleeding after tracheal extubation;
Emergency surgery;
Swan-Ganz catheter nonfunctioning"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-27fmyt	Effects of nutritional counseling and / or supplementation with Whey Protein on the nutritional status and metabolism of individuals with risk factors for Cardiovascular Diseases	Recruiting	Intervention	2018-01-05	<NULL>	<NULL>	1551	Effects of nutritional orientation and or supplementation with Whey Protein on the nutritional and metabolic status of individuals with risk factors for Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-27fmyt	<NULL>	Inclusion criteria were established for the participation of the research: adult women, aged between 20 and 59 years and BMI between 25 and 40 kg / m2.	Adult women diagnosed with renal, cardiovascular, hepatic, cancer, pregnant or lactating diseases will be excluded from the study, following a specific diet; Chronic alcoholics; On the use of anti-inflammatory medications or medicines that affect appetite or body weight; In inflammatory or infectious process on the day of collection; Who have participated in any food restriction program, in the use of food supplements in the last six months and lactose intolerant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-969mcq	Effects of Nutritional Supplementation on older seniors	Recruitment completed	Intervention	2020-02-17	<NULL>	<NULL>	3500	Effects of protein supplementation on body composition and functionality of oldest old residents in a Long-Term Care Facility	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-26	Pontifícia Universidade Católica do Rio Grande do Sul	Apsen Farmacêutica S. A.	https://ensaiosclinicos.gov.br/rg/RBR-969mcq	<NULL>	ILPI residents; both sexes; elderly aged 80 and over.	Undergoing surgery on the gastrointestinal tract previously.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-7gvrmm	Effects of Occlusion Exercise on blood pressure in patients with Knee Arthrosis	Recruiting	Intervention	2019-11-21	<NULL>	<NULL>	3211	Effects of a single session of Blood Flow Restriction Training on hemodynamic, autonomic and vascular responses in individuals with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-15	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)	Faculdade de Medicina, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7gvrmm	<NULL>	Post-menopausal women between 40-85 years, with knee osteoarthritis according to the criteria proposed by the American College of Rheumatology. The participants should present grade II or III of severity of the osteoarthritis according to Kellgren &amp; Lawrence and pain rated between 2 and 8 in the visual analogue scale.	The participants will be excluded if they present: cardiovascular, pulmonary, metabolic or any other disease that could preclude the procedures; systolic blood pressure greater than 160/105 mmHg; ischemia or arrhythmia during the exercise test; lower limb venous insufficiency; previous thrombosis and/or phlebitis in lower limbs; musculoskeletal impairment that preclude the performance of physical activity; body mass index greater than 35 kg/m2; under use of medications affecting the autonomic nervous system (e.g., beta blockers, and non-dihydropyridine calcium channel blocker); under use of anticoagulants; under glucocorticoid infiltration in the last 3 months; or under use of any glucorticoid in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-2mg3xw	Effects of olive oil treatments for facial dark spots	Data analysis completed	Intervention	2019-09-16	<NULL>	<NULL>	2946	Clinical efficacy of oral and topical treatments based on olive oil extract titrated in hydroxytyrosol to melasma control	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-30	Faculdade de Ciências Farmacêuticas de Riberão Preto - USP	Faculdade de Ciências Farmacêuticas de Riberão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-2mg3xw	<NULL>	30 to 50 years old; phototype III and IV (Fitzpatrick, 1998); facial hyperpigmentations patterns.	hyperpigmentations not diagnosed as melasma in the malar region; pregnancy or breastfeeding; individuals with a history of adverse reactions with the use of cosmetic products; individuals in the use of drugs capable of producing an abnormal skin response; cosmetic and dermo-cosmetic whitening treatments, superficial chemical peels and laser for less than 3 months; use of oral antioxidant supplementation for less than 3 months; localized or generalized dermatological diseases; excess hair on face.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-8dp876	Effects of Omega 3 and Cardo Mariano on MiRNAs related to non-alcoholic fatty liver disease.	Not yet recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1527	Epigenetic modulation by N-3 Polyunsaturated Fatty Acids and bioactive compounds (Silybum Marianum L) in Non-Alcoholic Fatty Liver Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-10	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8dp876	<NULL>	Be 19 years of age or older; diagnosis of NAFLD by abdominal ultrasonography, and liver biopsy in the last 24 months preceding the intervention	Viral hepatitis; infectious fever or outbreaks; cancer with or without chemotherapy and radiotherapy; inflammatory diseases of the gastrointestinal tract; transplant, trauma, surgery or hospitalization in the last 30 days; use of steroids or non-steroidal anti-inflammatories or immunomodulatory agents or antibiotics; use of n-3 fatty acid supplement in the last 3 months prior to study; pregnancy and lactation; alcohol intake greater than 20g / day for women and 30g / day for men	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-7nh566t	Effects of Omega-3 and Aspirin, with or without Antibiotics, in the treatment of Severe Gum Disease	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7786	Clinical and microbiological effects of Immune modulation, with or without Systemic Antibiotics, in the treatment of Periodontitis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-09-01	Universidade Guarulhos	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-7nh566t	<NULL>	Severe periodontitis; at least 15 teeth; aged over 29 years; males and females	Smokers; former smokers for at least 5 years; pregnant or lactating women; history of periodontal treatment in last 6 months; continuous use of oral antiseptics; use of systemic antibiotics, corticosteroids, non-steroidal anti-inflammatory drugs, immunosuppressants, estrogen, and estrogen receptor modulators; medicines that may influence bone metabolism, such as alendronate, calcitonin, and others, in the last 6 months; continuous use of medications; a systemic disease that may alter the response to periodontal or requiring prophylactic medication for dental treatment; report of allergy to metronidazole or amoxicillin, aspirin or fish and seafood; use of orthodontic appliances; prostheses; blood dyscrasias, gastritis or gastric ulcer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8cb536g	Effects of Omega-3 Supplementation, associated or not with Physical Exercise in patients with Metabolic Syndrome	Not yet recruiting	Intervention	2022-05-24	<NULL>	<NULL>	5402	Effects of Omega-3 Supplementation, associated or not with High-intensity Physical Training on anthropometric, physiological, biochemical and molecular parameters in patients with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8cb536g	<NULL>	Both sexes; age between 20 and 60 years; diagnosis of grade I obesity (Body Mass Index between 30.0 and 34.9 kg/m²) and type 2 diabetes mellitus; exclusive use of metformin; no evidence of coronary artery disease (history of angina, history of myocardial infarction or acute coronary syndrome, history of abnormal segmental motion of the heart wall on echocardiography); no bowel disease (short bowel syndrome, irritable bowel syndrome, Chron&apos;s disease, ulcerative colitis, celiac disease, colorectal cancer); no diseases related to the central nervous system (Alzheimer&apos;s, Parkinson&apos;s, hepatic encephalopathy, autism spectrum disorders); physical inactivity according to the International Physical Activity Questionnaire (short version); signing the informed consent form (ICF).	Individuals with musculoskeletal or cardiovascular limitations that make physical exercise impossible; fasting blood glucose greater than 300 mg/dl; use of any drug of continuous use for less than 3 months (except metformin); use of antibiotics, non-steroidal anti-inflammatory drugs or corticosteroids in the last month; use vitamin/food supplements that contain omega-3; individuals with genetic and hormonal limiting disease; abuse of alcohol and drugs; retinopathy; pregnancy or lactation; life expectancy less than 6 months (example: metastatic malignant neoplasm); patients with renal failure or congestive heart failure; individuals with previous organ transplants; wheelchair users; individuals with weight loss in the last 3 months (voluntary or not); volunteers in another experimental study on the date of enrollment; individuals who do not have access to the internet; discontinuation of omega-3/placebo use for 3 consecutive days; non-compliance with the physical activity protocol for 2 consecutive sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-6swqd2	Effects of Oncotherad Immunotherapy in the Treatment of Bacillus Calmette-Guérin (BCG)-Recurrent and Relapsed Non-Muscle Invasive Bladder Cancer	Recruiting	Intervention	2019-08-20	<NULL>	<NULL>	2884	Effects of Oncotherad Intravesical Imunotherapy in the treatment of Bacillus Calmette-Guérin (BCG)-Refractory and Relapsed Non-Muscle Invasive Bladder Cancer patients	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2018-08-17	Universidade Estadual de Campinas (UNICAMP)	Hospital Municipal de Paulínia (HMP)	https://ensaiosclinicos.gov.br/rg/RBR-6swqd2	<NULL>	Patients, 18- to 95-year-old, with BCG-refractory and relapsed non-muscle invasive bladder cancer.  In addition, patients refractory to approved first and second line chemotherapy, who are at increased risk of progression to muscle invasive and / or metastatic disease, will be included. Acceptance of the Informed Consent Form (TCLE); multiple (greater than two lesions) and / or recurrent and / or large (greater than 3 cm) tumors TaG1-2; non-muscle invasive tumor (pT1); presence of carcinoma in situ (Cis); urothelial carcinoma of the bladder grade 3.	Patients with bladder lesion suspected of malignant neoplasm and who were not previously submitted to Transurethral Resection (TUR), ie, treatment-naive patients for the bladder tumor. Histology: adenocarcinoma, squamous cell carcinoma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-7y8r4tz	Effects of one session of presential and remote strength exercises on pain and health aspects of pregnant women	Recruitment completed	Intervention	2023-05-01	<NULL>	<NULL>	6426	Effects of in person and remote strength training session on pain and health parameters of pregnant women: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7y8r4tz	<NULL>	Women; healthy; age between 18 and 45 years; gestational age between 12 and 35 weeks; be performing prenatal care; to be clinically able to carry out the different training programs proposed in the study; have a medical certificate for the practices; have internet access and devices that allow video connection; having availability of own displacement to carry out face-to-face sessions; not being involved in any systematic physical training program in the last three months; reporting low back pain during pregnancy	Present absolute contraindication to the practice of exercises proposed during the study, according to criteria established by the American College of Obstetricians and Gynecologists (ACOG)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-534ppvp	Effects of one-year treatment of Equine-Assisted Therapy in children with Cerebral Palsy	Recruitment completed	Intervention	2023-07-31	<NULL>	<NULL>	6579	Influence of hippotherapy on postural balance, gait and functional performance in children with cerebral palsy.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-23	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-534ppvp	<NULL>	"Having a medical diagnosis of Cerebral Palsy with an indication for the practice of hippotherapy through an appropriate assessment. Have from 2 to 14 years old. Possess cognitive ability to respond satisfactorily to the commands requested so that they are able to participate in data collection. Remain in the bipedal orthostatic position without using shoes or orthotics for 20 seconds. Have independent gait without and with the use of devices due to the data collection procedure.
Have hip abduction of at least 20 degrees to remain seated on the horse. Children could undergo conventional physical therapy in addition to Riding Therapy."	Do not meet the requirements of the inclusion criteria. Have undergone a surgical procedure in the last 12 months or are planning a surgery for the research period. Have performed neuromuscular chemical block for less than 6 months or are planning to perform it during the research period. Have uncorrected visual or hearing deficits. Having uncontrolled seizures, hip dislocation, excessive contracture of adductors and severe osteoporosis or any other reason that prevents you from riding a horse, such as excessive fear. If they do not have at least 75% attendance at hippotherapy sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-59bh5rc	Effects of online and face-to-face Pilates classes on the quality of life of the elderly	Recruitment completed	Intervention	2023-06-20	<NULL>	<NULL>	6165	Effects of Pilates training performed remotely and in person on the quality of life of the elderly: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-13	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-59bh5rc	<NULL>	Age between 60 and 70 years; not practicing physical exercises regularly and systematically for at least three months; be literate; have access to the internet and a device for video calling (cell phone, notebook/computer or tablet); have the availability to travel to the School of Physical Education, Physiotherapy and Dance (ESEFID) where classes will take place in the face-to-face format and assessments; not having uncontrolled cardiovascular diseases or associated complications; not present musculoskeletal problems that prevent the practice of physical exercise; reside in the city of Porto Alegre and its metropolitan region	Volunteers who do not attend 75% of the classes taught (regular classes or previously established replacements); physical adversity during intervention period and start the practice of another type of exercise physical concomitant with the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-6ysxd3v	Effects of orange juice intake on the intestinal microbiota in breast cancer patients undergoing chemotherapy	Recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8595	Longitudinal, prospective, and randomized study on the effects of acute orange juice intake on the gut microbiota in breast cancer patients treated with doxorubicin and cyclophosphamide	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-28	Departamento de Clínica Média - Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Women; over 18 years old; under follow-up at the Oncology service of the Hospital das Clínicas de Botucatu; diagnosed with any type of breast cancer; will receive treatment with doxorubicin in combination with cyclophosphamide.	Gastrointestinal tract disease prior to the cancer diagnosis; use of antibiotic therapy or medications that interfere with intestinal function (such as laxatives, intestinal motility inhibitors or stimulants, or pre/probiotics); constipation; diarrheia; vegetarians; vegans.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-2tr8m36	Effects of organizing a Program to Detect and Monitor Lung Nodules in people at high risk of Lung Cancer	Recruiting	Observational	2025-01-03	<NULL>	<NULL>	7635	Impacts of structuring a Lung Nodule Detection and Monitoring Program in a population at high risk for Lung Cancer	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2tr8m36	<NULL>	Individuals between the ages of 50 and 80; of either gender; current or former smokers for a maximum of 15 years; smoking history of 20 pack-years or more	Individuals who are unable to undergo the tomographic scan; individuals who present with symptoms highly suggestive of lung cancer as hemoptysis, chest pain, change in cough pattern, unintentional weight loss greater than 10 kg; diagnosis of severe lung or heart disease, use of multiple medications and/or need for home oxygen therapy; history of radiation therapy to the chest region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-6k7dwj	Effects of orthodontic treatment on promoting neural adaptations in adults with malocclusion	Recruiting	Intervention	2018-11-07	<NULL>	<NULL>	2320	Acute and chronic effects of Orthodontic Treatment for dental Alignment promote neural adaptations in Adults with Malocclusion: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-08	Faculdade de Ceilândia da Universidade de Brasília	Faculdade de Ceilândia da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6k7dwj	<NULL>	Adults between 18 and 59 years old. With malocclusion presenting anterior and / or posterior crossbite, on deep bite. Open bite. Dental crowding. Angle class I, II and III malocclusion.	Participants with a PAR index greater than 15 and less than 30 will be excluded from the clinical trial. Presenting central or peripheral neurological disorders. They suffer trauma and / or have a tumor in the head and neck region. Have scars on target skin regions of procedures. Fear of applying electrodiagnostic tests. For those with pacemakers. Users of total or partial dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-9zytwf	Effects of orthodontic treatment with clear aligner and conventional fixed appliance	Recruitment completed	Intervention	2019-10-25	<NULL>	<NULL>	3240	Effects of orthodontic treatment with clear aligner and fixed appliance: randomized clinical trial	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-06-12	Align Technology, Inc	Unopar	https://ensaiosclinicos.gov.br/rg/RBR-9zytwf	<NULL>	Fifteen to 35 years of age; both sexes; Angle Class I malocclusion; moderate anteroinferior crowding and treatment without extraction.	Absence of permanent teeth, anterior or posterior open bite, anterior or posterior crossbite, previous orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-4cmxry	Effects of Osteopathic and strength exercise in Resistance, Muscular Strength and Speed Blood  of Cardiac Patients.	Data analysis completed	Intervention	2017-08-02	<NULL>	<NULL>	1315	Effects of Treatment Osteopathic Manipulative (TMO) and resistance exercise circuit (REC) in cardiorespiratory capacity, Muscular Performance and Blood Flow of Patients with Heart Failure	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-17	Pós-graduação em Ciências e Tecnologias em Saúde da Faculdade de Ceilândia - UNB	Pós-graduação em Ciências e Tecnologias em Saúde da Faculdade de Ceilândia - UNB	https://ensaiosclinicos.gov.br/rg/RBR-4cmxry	<NULL>	Diagnosis of heart failure documented in the last 6 months; left ventricular systolic dysfunction &lt;35 % demonstrated by echocardiography; New York Heart Association classification ( NYHA ) class II and III and without participation in aerobic or resistance training programs in the last three months before the study protocol.	Individual previously diagnosed with moderate or severe chronic obstructive pulmonary disease; recent heart surgery in the last 3 months); morbid obesity; peripheral vascular disease and person who is not able to perform the exercise protocol resisted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-99r7gvd	Effects of osteopathic intervention in transition duration from enteral nutrition to oral feeding in infants admitted to a pediatric ICU	Recruiting	Intervention	2022-05-06	<NULL>	<NULL>	5381	Effects of osteopathic intervention in transition duration from enteral nutrition to oral feeding in infants admitted to a pediatric ICU - Randomized and controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-11	Hospital de Clinica da UNICAMP	Hospital de Clinica da UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-99r7gvd	<NULL>	Infants (28 days to 2 years) admitted to the pediatric ICU of HC Unicamp, using enteral nutrition through a nasogastric or nasoenteral tube that presents a risk factor for dysphagia. Informed Consent Form (TCLE) signed	Genetic syndromes. Chronic neuropathies. Structural anomalies of the digestive tract. Postoperative of neurological, gastrointestinal, face and upper and lower airways surgeries.  Cancer patients. Previous osteopathic treatment. Transfer of the infant to another service	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-23dgvk8	Effects of Osteopathic Manipulation Techniques on treatment of patients with Stroke	Recruiting	Intervention	2023-01-23	<NULL>	<NULL>	5839	Effects of Osteopathic Manipulation Techniques on treatment of patients with Brain Stroke Ischemic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Escuela de Osteopatia de Madri - Brasil Ltda	Escuela de Osteopatia de Madri - Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-23dgvk8	<NULL>	Men and women with a clinical diagnosis of up to 60 days after ischemic cerebrovascular insult in the middle cerebral artery; present an age group between 40 and 55 years; being in physical therapy treatment in a rehabilitation establishment neurofunctional; agree and sign the Free and Informed Consent Term	Present a stroke resulting from covid-19; associated neurological disease; infectious diseases; active autoimmune diseases; hemorrhagic stroke; previous history of stroke; deafness or significant hearing loss; and patients with cognitive disorders that impede the understanding of the questionnaires; untreated systemic arterial hypertension; pregnancy; smoking; alcoholic; not using antibiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-47nqzj2	Effects of Osteopathic Manipulative Treatment in women with Intestinal Constipation	Not yet recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6249	Effects of Osteopathic Manipulative Treatment in women with Functional Constipation: pragmatic randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Univerisade Estadual do Oeste do Paraná	Univerisade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-47nqzj2	<NULL>	Women; age range from 18 to 60 years; present functional constipation as mentioned in the ROME III criteria (LONGSTRETH et al., 2006)	Not accepting manipulations; pregnant women; being in the inflammatory phase of gastrointestinal or urinary diseases (kidney stones, appendicitis, colicistitis, peritonitis); presenting metabolic or cardiovascular diseases; having already undergone some surgical procedure on the spinal column or abdominal cavity; having undergone some type of treatment for constipation less than 6 months ago, such as: use of laxative medications and body massages or teas that alter intestinal motility; present contraindications for the Osteopathic techniques to be performed during the collection of the study, these being: recent fracture, osteoporosis and spinal tumor (PANAGOPOULOS et al. , 2015; FERNANDES et al., 2018)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9vf9x3w	Effects of Osteopathic Manual Therapy (OMT) on the Stress levels of workers in a hospital environment	Not yet recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7604	Effects of Osteopathic Treatment on Stress levels of workers in a hospital environment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-9vf9x3w	<NULL>	64 nurses and nursing technicians will be included; of both sexes; aged between 20 and 65 years old; all workers at the Polyclinic Hospital in the city of Cascavel/PR with at least six months of experience	All employees who are undergoing treatment with psychiatric medications will be excluded from this survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-5rq9bd8	Effects of Osteopathic Manual Treatment in Patients with Chronic Low Back Pain	Recruiting	Intervention	2024-03-02	<NULL>	<NULL>	6820	Effects of Osteopathic Manual Treatment protocols in patients with chronic Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-17	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-5rq9bd8	<NULL>	Subjects with lombar pain for at least 03 months, most days	Severe osteoporosis; progressive neurological disease; scoliosis above 30°; reumathic diseases; Laségue positive above 35°; previous lumbar surgery; patient using experimental treatments; patients undergoing another manipulative treatment out of this study; cancer; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-3x4pgn7	Effects of Osteopathic treatment associated with Transcranial Stimulation on pain in individuals with Chronic Low Back Pain. clinical, randomized, double blind, placebo controlled trial	Recruiting	Intervention	2020-12-16	<NULL>	<NULL>	5890	Effects of Osteopathic Manipulative Treatment associated with Transcranial Direct Current Stimulation on pain intensity in individuals with Nonspecific Chronic Low Back Pain. a randomized, double blind, placebo controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-15	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3x4pgn7	<NULL>	Both sexes; com idade between 18 to 55 years; that we will present lombar pain for more than 3 months; that it is not associated with any potentially serious illness or condition in accordance with the NICE guidelines (National Institute for Health and Care Excellence – UK, 2016); and that we will agree with your participation not studied by means of the subject of the term of free and informed consent.	Participants with the presence of a herniated disc; history of sleepiness or persistent weakness in the legs or leg, or history of claudication; confirmed by neurological evaluation or imaging test; that they are subjected to previous surgery in the lombar spine, that present neurological and/or orthopedic alterations that make it impossible and/or limit the patient&apos;s movements; that present malignant tumor; inflammatory or infectious disease; metal implants in the head; with mark steps; individuals who do not meet our inclusion criteria and individuals who will not grant the free and informed consent term.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-4p29wg5	Effects of Osteopathy and Ankle Self-Mobilization on Athlete Ankle Range of Motion Gain	Not yet recruiting	Intervention	2022-04-28	<NULL>	<NULL>	5371	Effects of Osteopathic Manipulative Treatment versus Talocrural Automobilization on Ankle Mobility and Functionality in Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	UDF - Centro Universitário do Distrito Federal	UDF - Centro Universitário do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-4p29wg5	<NULL>	Athletes who practice soccer, running, crossfit or any other modality that generates joint impact in the execution of their movements; practitioner of the modality with training frequency of at least three times a week; Age between 18 and 40 years; Possess reduced active range of motion (ROM) of ankle dorsiflexion (less than 20 degrees of ROM for dorsiflexion in one or both ankles), either in open kinetic chain (OCC) or chain closed kinetics (CCF)	Acute or chronic muscle, ligament, joint and/or tendon injuries; Use of lower limb prostheses; Congenital orthopedic and neurological injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-946wmb	Effects of osteopathy on pulmonary function in healthy	Data analysis completed	Intervention	2018-09-03	<NULL>	<NULL>	3734	Effects of Osteopathic Manipulative Treatment on the cardiovascular and respiratory systems of healthy youngsters	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Fundação Universidade de Brasilia	Fundação Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-946wmb	<NULL>	Healthy subjects; adults; male	Previous respiratory disease; ribcage deformity; respiratory infection in the past three months; caffeine previous evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-2hs894w	Effects of Oxandrolone on clinical outcomes and muscle mass in patients with Septic shock	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6543	Effects of Oxandrolone on clinical outcomes and muscle mass in patients with Septic shock: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Estadual Paulista Júlio de Mesquita	Universidade Estadual Paulista Júlio de Mesquita	https://ensaiosclinicos.gov.br/rg/RBR-2hs894w	<NULL>	Individuals over 18 years of age; of both genders; hospitalized with a diagnosis of septic shock in the Intensive Care Service of the Hospital das Clínicas da Faculdade de Medicina de Botucatu from October 2023 to June 2025	Patients with the following characteristics will be excluded: pregnant women; noradrenaline dose &gt; 2.0µg/Kg/min; patients with non-functioning gastrointestinal tract; diagnosis of brain death; patients with a history of previous use of anabolic steroids; association with other types of shock (cardiogenic, hemorrhagic or hypovolemic); patients with breast or prostate cancer and those who spontaneously refuse to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-8z86dk	Effects of Ozone  and Physiotherapy on the treatment of Rheumatoid Arthritis of the hands	Not yet recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3401	Effects of Ozone Therapy and Kinesiotherapy on the treatment of Rheumatoid Arthritis of the hands	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-28	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-8z86dk	<NULL>	"Individuals aged 18 and over; People of both sexes;Patients diagnosed with hand 
rheumatoid arthritis."	Individuals with severe neuromotor sequelae; Patients unable to verbalize or perform the proposed tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-9srx44	Effects of ozone therapy on management of pain, swelling, and trismus following mandibular third molar surgery	Terminated	Intervention	2020-03-06	<NULL>	<NULL>	3567	Effects of ozone therapy on management of pain, swelling, and trismus following mandibular third molar surgery	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2019-04-10	renato baiao de almeida	renato baiao de almeida	https://ensaiosclinicos.gov.br/rg/RBR-9srx44	<NULL>	pacients with 18 years old or more; without sitemic diseases and with included mandibular third molar on class ll B on the PELL-GREGORY/ WINTER classification score of difficulty of removing.	the exclusion critter is  contra-indication of ozone therapy, systemic diseases, local infection, tabagismo, oral contraceptives users, pregnant, lactate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-9rx83cv	Effects of OzoneTherapy on Abdominal Fat Reduction	Recruitment completed	Intervention	2022-04-05	<NULL>	<NULL>	5330	Effects of OzoneTherapy in the Treatment of Localized Abdominal Fat	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-06-15	Universidade Potiguar	Universidade Potiguar	https://ensaiosclinicos.gov.br/rg/RBR-9rx83cv	<NULL>	In the inclusion criteria, participants must be aged between 25 and 45 years, Body Mass Index (BMI) between 18.5 and 29.99 (Normal to Overweight), not regular practitioners of physical activities and must have the ability to understand and preserved local sensitivity.	The exclusion criteria will apply to all participants who are allergic to ozone, are under dietary restriction (diet, dietary re-education, etc.), are using anti-inflammatory medications up to 1 week before the start of the study. If any of the volunteers need to take medication within 1 month after the start of the study, they will be discarded from the sample, present any contraindication related to ozone therapy, such as hyperthyroidism or decompensated arterial hypertension, severe anemia, recent bleeding of organs, cachexia and pathologies with high stress oxidative. Participants who do not agree with the procedures, present sensitivity disorder during therapy, or do not adapt to the schedules and procedures will be discontinued from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-4zmjwv8	Effects of Ozonotherapy on Localized Abdominal Fat	Recruitment completed	Intervention	2021-09-30	<NULL>	<NULL>	4925	Effects of Ozonetherapy on Localized Abdominal Fat	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-06	Centro Universitário da Serra Gaúcha	Centro Universitário da Serra Gaúcha	https://ensaiosclinicos.gov.br/rg/RBR-4zmjwv8	<NULL>	To compose the sample of this research, women will be selected, aged between 18 and 60 years, with a Body Mass Index between 18.5 and 29.99 (Normal to Overweight), who are not practicing physical activity, diet, with capacity for understanding and preserved local sensitivity and that they accept to participate in the research by signing the Free and Informed Consent Term.	As exclusion factors for the research intervention, it was determined that the sample participants do not present any contraindication related to ozone therapy, such as hyperthyroidism or decompensated arterial hypertension, severe anemia, recent bleeding of organs, cachexia and pathologies with high oxidative stress, which will be proven through laboratory tests. Also excluded from the sample will be participants who have a body mass index greater than 30, who are undergoing another aesthetic treatment or who have recently undergone surgery, and those who are in the gestational period. Participants who refuse to sign the Free and Informed Consent Term will also be excluded from the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-5r9j6kg	Effects of Palatal Expansion on the Oral and General Health of Children with Enlarged Adenoids and Tonsils	Recruiting	Intervention	2026-04-02	<NULL>	<NULL>	9051	Effects of Rapid Maxillary Expansion on the Oral and General Health of Patients with Hypertrophic Adenoids and Palatine Tonsils: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-19	Departamento de Estomatologia	<NULL>	<NULL>	<NULL>	Children aged 5 to 7 years; of both sexes; who require surgical intervention (adenotonsillectomy); presenting with maxillary atresia; and with unilateral or bilateral posterior crossbite, whether apparent or functional.	Children requiring other modalities of interceptive orthodontic treatment during the experimental period; patients using medications that alter bone metabolism; patients with a body mass index greater than twenty-five; patients with craniofacial malformations; and patients with cognitive impairments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-4fw87f	Effects of Patellar Taping in Subjects with Knee Pain	Recruiting	Intervention	2013-07-15	<NULL>	<NULL>	211	Influence of Patellar Taping on Baropodometric Characteristics of Subjects with Patellofemoral Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-09-18	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4fw87f	<NULL>	Women aged between 18 and 35 years, with pain in the anterior knee insidious onset, no history of trauma in the region. Duration of symptoms for longer than 12 weeks and triggered by  perform two of the following activities: up or down stairs, squatting, sitting for long stay; while practicing physical activity. On physical examination must present pain in two of four tests: isometric contraction of the quadriceps, squats, palpation of the medial or lateral patellar and step down. To compose the control group will be selected women without musculoskeletal symptoms in the lower limb.	Women who underwent physical therapy for the lumbar spine, pelvis and lower limbs in the last 6 months prior to collection. With a history of neurological diseases and surgery of the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-4nmdwr	Effects of pecan nut consumption on the metabolism of adults with Obesity	Recruitment completed	Intervention	2019-09-24	<NULL>	<NULL>	2995	Metabolic effects of pecan nut consumption in adults with Obesity: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-12	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4nmdwr	<NULL>	Volunteers aged 20 to 59 years; body mass index (BMI) equal to or greater than 30 kg / m² due to excess body fat; who agreed to participate voluntarily in the study; and that they would be willing to follow the proposed recommendations.	Participants with: 1) psychiatric disorders, history of cancer, endocrine disorders (adrenal diseases, thyroid diseases, polycystic ovarian syndrome, diabetes mellitus and dyslipidemia in drug and non-drug treatment), spoliation status (fever, malabsorption syndrome, surgery), inflammatory, infectious, autoimmune, renal, cardiovascular, hepatic (cirrhosis, hepatitis, and hepatic insufficiency) diseases; 2) use of weight-loss, appetite-suppressing, immunosuppressive, anti-inflammatory, corticosteroid, antibiotic, hypolipidemic, antidiabetic, anticoagulant, antihypertensive, hormonal (except stable contraceptive use for at least 6 months); 3) frequent consumption of nuts, including peanuts and baru almonds (one or more times in the week); 4) allergy or food intolerance to any type of nuts (including peanuts or baru almonds); 5) use of dietary supplements; 6) alcoholics, smokers or drug abuse; 7) women in climacteric, pregnant and nursing mothers; 8) performing restrictive diet or dietary treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-6gdktv	Effects of PEEP-ZEEP technique on pulmonary secretion removal and respiratory system.	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1567	Effects of PEEP-ZEEP Maneuver on pulmonary secretion clearance and respiratory mechanics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-09	Universidade Federal do Triângulo Mineiro	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6gdktv	<NULL>	Patients with pulmonary secretion on mechanical invasive ventilation; hemodynamically stable (MBP higher than 65 mmHg); PEEP lower or equal than 10 cmH2O; oxygen inspiratory fraction lower or equal than 0,4; peripheral oxygen saturation higher than 90%.	Intracranial hypertension; cor pulmonale; pulmonary hypertension; pregnancy; pneumothorax not drained; bronchospasm; rib fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-49dk634	Effects of Pelvic Floor Training in the preoperative period of Radical Prostatectomy on Urinary Incontinence and Erectile Dysfunction	Not yet recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6304	Effects of a Pelvic Floor Muscle Training Program in the preoperative Radical Prostatectomy on Urinary Incontinence and Erectile Dysfunction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-20	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-49dk634	<NULL>	Men between 55 and 80 years of age; localized prostate cancer	Patients with metastatic cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-28x7hqf	Effects of Percussive Massage Gun massage on the physical assessment of athletes: a randomized controlled trial	Not yet recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5218	Effects of the Percussive Massage Gun on clinical and biomechanical outcomes in athletes: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal do Ceará	Departamento de Fisioterapia da Universidade Federal do Ceará (UFC)	https://ensaiosclinicos.gov.br/rg/RBR-28x7hqf	<NULL>	Age equal to or greater than 18 years old, with at least six months of practice with weekly training frequency equal to or greater than three days, and who have not suffered musculoskeletal injuries in the last three months	Practitioners unable to perform the biomechanical tests, pregnant women, using a cardiac pacemaker, with cognitive impairment or who have undergone any surgical procedure in the last three months will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-387ntq	Effects of Perineal Stretching in pregnant women who performed Exercises in the Perineal Region	Not yet recruiting	Intervention	2019-08-22	<NULL>	<NULL>	2889	Effects of Perineal Stretching in pregnant women performing Pelvic Floor Muscle Training: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-387ntq	<NULL>	Inclusion criteria will be considered: age over 18 years; gestational age of 33 weeks; primigravidae; physiological gestation; medical authorization to perform the intervention; pregnant women wishing to deliver vaginally; present medical certificate of release for participation in the research. For the pregnant women who will be part of the T Group, they will also have as inclusion criterion to have performed PFMT, during the gestational period, offered by the project approved by CEP / UFU, 3,054,152. For the pregnant women of the NT Group, the criterion is not to have performed PFMT.	The exclusion criteria will be: multiple gestation; presence of bone deformities; important muscular and nervous dysfunctions; presence of high gestational risk; unusual fetal position or risks that make vaginal delivery impossible (placenta previa); presence of risk of ascending infection; presence of vaginal bleeding; presence of cervical cancer; inability to contract the pelvic floor muscles; intolerance to vaginal palpation; presence of neurological and / or cognitive deficits that prevent the understanding of the procedures; use of prenatal pelvic floor preparation methods before being part of the study; being visibly under the influence of drugs or alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-4c3pdbz	Effects of periodontal therapy in individuals with obesity	Recruiting	Intervention	2024-11-08	<NULL>	<NULL>	7496	Effects of non-surgical periodontal therapy in the treatment of Periodontitis in individuals with obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4c3pdbz	<NULL>	Volunteers of both genders; presence of at least 15 natural teeth excluding third molars and teeth with indication for extraction; diagnosis of generalized periodontitis stage III grade A or B; 30% of teeth with probing depth and clinical attachment level greater than or equal to 5mm	Body Mass Index (BMI) between 25 kg/m2 and 29.9 kg/m2; presence of systemic conditions that may affect the progression of PE or the response to its treatment; long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and/or use of antimicrobials in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; chronic gastrointestinal diseases; extensive prosthetic rehabilitations; tobacco use currently or in the last 5 years; pregnancy and lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-4dx6fk	Effects of Periodontal Treatment in renal conditions	Recruiting	Intervention	2019-11-01	<NULL>	<NULL>	3165	Effects of Periodontal Treatment in renal outcomes of Pre-Dialytic patients: randomized controlled trial of 12 months of follow-up	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-06-27	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4dx6fk	<NULL>	Stage 3 and 4 chronic kidney disease; Glomerular filtration rate lower than 60 ml / min / 1.73 m², without being in dialysis; Having more than 18 years of age; Not being HIV positive; Not having diagnosis, nor being in treatment of malignant neoplasia; Do not be pregnant or nursing; Moderate periodontitis according to the definition criteria of (2 or more interproximal sites with depth of probing of 5mm or more or 2 or more interproximal sites with loss of insertion of 4mm or more); Present at least 10 teeth present; Negative medical history of any systemic condition that necessitates the use of antimicrobial chemoprophylaxis.	Periodontal treatment in the last 6 months; Pregnant or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-33j54zk	Effects of Periodontal Treatment on radiotherpay induced Oral Mucositis	Not yet recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8720	Impacts of Basic Periodontal Treatment on  Radiation-induced Oral Mucositis.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Head and neck cancer patients aged 18 years or older; patients diagnosed with periodontal health or periodontitis stages I, II, III, or IV; Patients who will undergo head and neck radiotherapy as part of the oncologic treatment plan for head and neck cancer	Patients under 18 years old; Patients who have received dental treatment within the six months preceding recruitment; Pacients who have previously undergone radiotherapy or chemotherapy; Patients who are currently using bone resorption inhibitors or immunosuppressive drugs	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-8cfptjf	Effects of perioperative fasting abbreviation in dentofacial corrective surgery	Recruitment completed	Intervention	2023-10-17	<NULL>	<NULL>	6513	Effects of perioperative fasting abbreviation in orthognathic surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-10	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8cfptjf	<NULL>	Volunteers with dentofacial deformity, with indication for correction by orthognathic surgery of the jaws; age between 18-60 years; physical status (ASA) I or II; body mass index less than 30 kg/m2; who can decide about their participation in the study.	Volunteers with allergies to the drugs used in the research; milk protein allergy; with diseases that may affect gastric emptying, such as hiatal hernia and gastroesophageal reflux; diabetes; use of hypoglycemic agents; gestation; rheumatic diseases;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-26x4qtw	Effects of peripheral ischemia on clinical recovery in patients with stroke	Not yet recruiting	Intervention	2025-02-19	<NULL>	<NULL>	7766	Effects of ischemic post-conditioning on clinical recovery in patients with stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Hospital Universitário da Universidade Estadual de Ponta Grossa	Grupo de Estudo sobre Respostas e Adaptações Fisiológicas ao Exercício da Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-26x4qtw	<NULL>	Both-gender patients; diagnosed with Ischemic Stroke with infarction of large arteries or small arteries; aged between 45 and 65 years; with clinical stability; independence prior to the event; degree of acute Ischemic Stroke at the time of hospital admission between 5 and 20 on the National Institutes of Health Stroke Scale will be included	Patients with infarctions of cardioembolic origin; patients whose investigation does not define the site of infarction; with previous Stroke; with systolic blood pressure above 200 mmHg; with ulcerative lesions in the lower limbs; patients who, after thrombolytic therapy, present lower than 5 points on the National Institutes of Health Stroke Scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-9c4jnv4	Effects of Photobiomodulation and Ozone Therapy on pain and functionality in knee osteoarthritis	Recruiting	Intervention	2023-07-12	<NULL>	<NULL>	7221	Comparative analysis of the effects of Photobiomodulation and Ozone therapy on pain and functionality of individuals with knee osteoarthritis: Controlled and Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9c4jnv4	<NULL>	diagnosis of knee osteoarthritis (KOA) grades II and III confirmed by radiological examination according to the American College of Rheumatology - Kellgren-Lawrence criteria (Link et al., 2013); women; age between 50 and 70 years; body mass index (BMI) between 22 and 30 kg/m²; classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire – short version (IPAQ); availability to participate in the treatment plan; clinical signs such as pain and joint stiffness in at least one of the compartments of the knee joint (medial or lateral tibiofemoral and patellofemoral joint)	medical restrictions that make it impossible to participate in the study evaluations (cardio-respiratory, rheumatic, neurological and vestibular alterations); systemic arthritis; body mass index greater than 30 kg/m2; symptomatic hip osteoarthritis (OA); use of conventional, unconventional or alternative treatments that could potentially have an effect on the study results (physiotherapy and/or intra-articular corticosteroid or hyaluronic acid injections during the last 3 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-9wnkk7	Effects of Photobiomodulation on anterior serratio muscle, Electromyographic Fatigue, and conjunct action of shoulder muscles	Recruiting	Intervention	2017-10-07	<NULL>	<NULL>	1415	Effects of Photobiomodulation on anterior serratus muscle and electromyographic indicators of Fatigue and synergism of shoulder muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-9wnkk7	<NULL>	Age between 20 and 30 years; full and non-painful active range of motion of the shoulder; elbow and wrist joints; Body mass index (BMI) less than or equal to 27; Considered not very active by the International Physical Activity Questionnaire (IPAQ); have not been in training for at least three months.	Musculoskeletal dysfunction in shoulder, wrist and hand elbow; Weakness of the anterior serratus muscle; winged scapula; history of trauma or previous surgery in the upper extremities; subluxation of the glenohumeral joint; rheumatic, degenerative or neurological disease; patients with diabetes mellitus and fibromyalgia; patients with uncontrolled hypertension; regular intake of drugs and dietary supplements; Fitzpatrick Type Scale Type V and Type VI classification and physical training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-5tkh5hv	Effects of Photobiomodulation on heart rate variability responses in bodybuilders	Recruitment completed	Intervention	2023-06-06	<NULL>	<NULL>	6137	Assessment of heart rate variability in bodybuilders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-14	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-5tkh5hv	<NULL>	Non-athletes, who practice light physical activities (according to the perceived effort scale proposed by Borg (2000). Both sexes and who do not have a history of musculoskeletal injury in the regions of the arms, hips and knees; Age between 18 and 50 years and who can give informed consent; Physical exercise training for at least 03 months; Healthy individuals who do not have contraindications to Photobiomodulation Therapy (FBM)	Chronic alcoholic or who frequently ingest caffeine products; vasodilators, psychotropics and anti-inflammatory drugs; Individuals with neurological and muscular diseases; Pain or limitation in movements of the upper or lower limbs and suffered some type of serious injury in the last six months; Having chronic systemic diseases, for example, diabetes mellitus, systemic hypertension, cardiovascular, renal, brain diseases, neoplasms or HIV-AIDS; Cognitive inability to understand or communicate important	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-7nbnpc	Effects of photobiomodulation therapy applied immediately before resistance training in type 2 diabetic women	Data analysis completed	Intervention	2018-05-21	<NULL>	<NULL>	1827	Low-Power Laser Effects Applied to Resistant Pre-Training in Old Type 2 Diabetics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-05	Associação Educacional Nove de Julho	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7nbnpc	<NULL>	Women aged 60 to 79 years were included; diagnosis of Type 2 Diabetes Mellitus for at least 1 year; cognitive score greater than 18 in Minimental; glycated hemoglobin above 6.5%; casual blood glucose up to 250 mg / dl; body mass index up to 40kg / m2; make use of insulin only as supplementation of glycemic control; normal or controlled systemic blood pressure with medication; released by the doctor to physical exercise	As voluntárias foram excluídas se realizassem exercícios físicos regulares ou fisioterapia motora; na presença de alterações auditivas; visuais e/ou motoras severas; ou ainda qualquer situação de saúde que impedissem a aplicação dos instrumentos avaliativos e a execução da intervenção proposta. Foram excluídas ainda se tivessem 2 faltas consecutivas ou 3 faltas alternadas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-4gq6khr	Effects of Photodynamic Therapy as aid on non-surgical treatment of Aggressive Periodontitis	Not yet recruiting	Intervention	2020-12-10	<NULL>	<NULL>	4409	Effects of Photodynamic Therapy as aid on non-surgical treatment of Aggressive Periodontitis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-12-16	Universidade Federal do Rio Grande do Norte	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4gq6khr	<NULL>	Individuals between 18 and 40 years old with a clinical diagnosis of Aggressive periodontitis, according to the American Academy of Periodontics (1999) or Periodontitid satages III or IV grade C; Presence of at least 8 teeth with PS &gt; 5 mm and CIN ? 5 mm, 2 teeth per quadrant; Agree to participate in the survey by signing the informed consent form	Pregnant and lactating women; Carriers of systemic diseases that compromise the immune system; Unable to answer the questionnaires or perform the tests or treatment; Allergic to Amoxicillin, Metronidazole, Chlorhexidine or Photosensitizer;Those who underwent periodontal therapy less than 6 months ago.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-3cj934	Effects of phototherapy on chronic low back pain	Recruiting	Intervention	2018-02-21	<NULL>	<NULL>	1649	Effects of photobiomodulation on pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-3cj934	<NULL>	It will be included volunteers of both genders; adults; aged between 20 and 65 years; body mass index (BMI) between 20 and 34.9 km/m2, who are eutrophic subjects; pre-obese or with moderate obesity (degree I). Volunteers should report complaints of low back pain for a period equal or greater than 3 months, with the same intensity, irradiated or not for their lower limbs.	It will be excluded volunteers who present lumbar cancer; coagulation disorders; infection; neurological deficits; and volunteers who use anti-inflammatory; and / or analgesic drugs during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-38wn44	Effects of Phototherapy on Diabetes Mellitus and Control of Cardiac Function	Recruitment completed	Intervention	2018-02-21	<NULL>	<NULL>	5892	Effects of Photobiomodulation on Diabetes Mellitus and Cardiac Autonomic Control	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-10	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-38wn44	<NULL>	Volunteers of both genders were recruited; aged between 40 and 80 years; body mass index (BMI) between 20 and 39.9 km/m2, ie, eutrophic; pre-obese or moderately obese subjects (grade I); and obese (grade II). Volunteers should be clinically diagnosed as diabetic (fasting glycemia less than or equal to 126 mg / dL); and be sedentary or irregularly active according to the short version of the IPAQ.	Volunteers who presented cancer were excluded; or history of cancer in the region of the lower and upper limbs; infection; neurological deficits; have coagulation disorders; as well as insulin-dependent volunteers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-2s4tpw	Effects of phototherapy on pressure ulcers	Not yet recruiting	Intervention	2020-01-02	<NULL>	<NULL>	3319	Effects of photobiomodulation on pressure injury stages 2 and 3 clinical controlled randomized blinded study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	São Paulo Secretaria da Saúde	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2s4tpw	<NULL>	Participants over 18 years. Both sexes. With pressure injury stages 2 or 3. Length of stay 15 days.	Participants with active neoplasms or palliative care; osteomyelitis in the wound region or with stage 1 or 4 pressure injuries. Deep tissue injury; unclassifiable lesions; complex wounds, necrotic; infected  will be excluded. Patients with a history of photosensitivity to photonic therapy or who have significant neurological or psychiatric disorders will also be excluded from the study as it compromises assessments of uncoupling or pain during photobiomodulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4g2jw3	"Effects of physical activities to control chronic diseases
with blood analysis, work environment and physical inactivity in military police: clinical study"	Not yet recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2739	"Effects of interventions to control chronic diseases
with biochemical, environmental-occupational and
sedentary behavior in military police: clinical study"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-06	Universidade São Judas Tadeu	Universidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-4g2jw3	<NULL>	To be a military police officer, volunteer, of units: operational and administrative; Male and female; Be in the condition of &quot;active&quot; service; Have at least one year of experience in the Units they serve; Sign the free and informed consent form (TCLE); Have a medical certificate to practice physical activity assessing their clinical state of health to perform interventions with military police.	Police officers working inside the State; Police officers who are already in the paid and retired reservation; Military officers under 25 and over 58; is unable to make interventions for clinical, administrative or judicial purposes within the period specified in the schedule.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-3wk3cr	Effects of physical activity  on cognitive functions (attention, memory, processing speed and  executive function), bain-derived neurotrophic factor (BDNF) and cortisol levels in older women.	Recruitment completed	Intervention	2016-10-17	<NULL>	<NULL>	1041	Effects of physical activity  on cognitive function and BDNF and cortisol levels in older women.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-30	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3wk3cr	<NULL>	Ages between 60 and 90 years; not being physically active in the last 6 months; at least 4 years of formal education; present a medical certificate permiting the participation in the physical activity protocol.	Previous  or  current  history of neurological diseases; dementia; major unstable medical conditions; pathological conditions that modify cortisol and BDNF levels; visual and hearing dysfunctions; use of medications that interfere with cognitive functions, BDNF levels or HPA axis; previous or current drug abuse; lower-limb amputation or bone fractures in the past 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-3vwdms	Effects of physical activity in chronic kidney disease in diabetic origin	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1473	"Effects of a physical rehabilitation program in patients with diabetic nephropathy,
with different types of exercises compared to proteinuria- randomized clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-02	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-3vwdms	<NULL>	"Minimum age of 18,;
Patients with chronic kidney disease; diabetic source characterized by albuminuria greater than 300 mg / g creatinine; with a sample of 50 persons."	"Patients who are on dialysis;
History or evidence of angina or myocardial infarction;
Positive Exercise Stress Test for coronary disease;
Cardiac arrhythmias;
Musculoskeletal restrictions that preclude participation;
Hemodynamic instabilities;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-62jk22	Effects of physical exercise and nutrition on the risk of heart disease in adults and elderly in city San Antonio of Goiás	Data analysis completed	Intervention	2016-09-08	<NULL>	<NULL>	986	Metabolic syndrome: prevalence and effects of physical exercise and nutritional supplementation in adults and elderly of city Santo Antonio Goiás	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-10	Universidade Federal de Goiás	Paulo Adriano Naves Prudente	https://ensaiosclinicos.gov.br/rg/RBR-62jk22	<NULL>	Women; age 18-59 years; not be taking regular exercise and targeted to at least one year; have the permission of the medical team for physical exercise; availability time in three days a week in the evening for an hour a day for 6 months; no orthopedic limitations; absence of neurological limitations; absence of severe cardiovascular disease that would prevent the practice of physical exercises.	Unavailability time; history of abuse of alcohol or drugs; We are practicing physical exercise regularly over the past 12 months; not have medical clearance for physical exercise; physical limitations that prevent physical exercise; neurological limitation that prevents physical exercise; cardiovascular disease in serious condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-6y2srf	Effects of physical exercise and recreational activities in the memory loss of Primary Health Care elderly users.	Recruiting	Intervention	2015-09-30	<NULL>	<NULL>	625	Effects of an aerobic, strength and cognitive training program on the mild cognitive decline of Public Primary Health Care elderly users in Porto Alegre	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-11	União Brasileira de Educação e Assistência	União Brasileira de Educação e Assistência	https://ensaiosclinicos.gov.br/rg/RBR-6y2srf	<NULL>	Both genders volunteers; aged 60 years and over; independent at activities of daily living; able to walk independently to the location of training and testing; mild cognitive impairment detected by the Addenbrooke Cognitive Examination (2007 revised version).	Severe psychiatric disorder or traumatic brain injury; use of acetylcholinesterase inhibitors; current substance abuse; important communication deficiencies; simultaneous participation in other research studies; regular practice of physical activity (at least once a week in the last three months); physical therapy treatment in the last three months; physical and functional limitations that might prevent the practice of physical activity; conditions that promote disabilities; visual deficits that prevent reading; recurrent vertigo; uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-96d3pvr	Effects of physical exercise and red grape juice on oxidative stress, inflammation and cardiac autonomic modulation in patients with Cystic Fibrosis	Recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6908	Effects of Physical Training and Red Grape Juice on oxidative stress, inflammation and cardiac autonomic modulation in patients with Cystic Fibrosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-02	Hospital Universitário Lauro Wanderley/HULW, Universidade Federal da Paraíba/UFPB	Hospital Universitário Lauro Wanderley/HULW, Universidade Federal da Paraíba/UFPB	https://ensaiosclinicos.gov.br/rg/RBR-96d3pvr	<NULL>	Diagnosis of Cystic Fibrosis by positive sweat test and/or presence of one or more mutations in the cystic fibrosis transmembrane regulatory gene (CFTR) ; not being indicated for or having undergone lung transplantation; no renal or hepatic dysfunction; be between 5 and 18 years old; do not regularly consume red grape juice, as well as food supplements that contain bioactive substances present in grapes (polyphenols)	Participants who do not perform all procedures; experience gastric discomfort with ingestion of grape juice during the study; present changes in kidney or liver function; have intolerance to physical training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-7w6qb8	Effects of physical exercise and the use of nutritional supplement on overweight, hypertension and diabetes	Recruitment completed	Intervention	2016-12-08	<NULL>	<NULL>	1097	Metabolic syndrome: prevalence and effects of exercise and nutritional supplementation in adults and the elderly of the city of Santo Antônio de Goiás	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-08	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7w6qb8	<NULL>	Volunteers with waist circumference greater than 80 cm; female; age between 20 and 69 years; away gestational period and no allergy to colorants.	Volunteers with waist circumference less than 80 cm; male; the age of 20 and more than 69 years; pregnant women and allergic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-8ykyws	Effects of physical exercise and vitamin D supplementation on muscle mass of  hemodialysis patients	Recruitment completed	Intervention	2015-06-25	<NULL>	<NULL>	1435	Effects of physical training and vitamin D supplementation on muscle mass of  hemodialysis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-30	Faculdade de Medicina de Botucatu	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8ykyws	<NULL>	Individuals older than 18 years; with chronic kidney disease on dialysis for a period greater than or equal to three months; classified as sedentary or irregularly active according to the International Physical Activity Questionnaire (IPAQ); do not have contraindications to physical activity; and accept and sign the Informed Consent.	Individuals unable to understand the procedures performed; prior diagnosis of coronary artery disease; positive exercise test for cardiac ischemia; patients classified as active or very active based on the International Physical Activity Questionnaire; Patients who have suffered stroke; patients with cancer, liver failure, chronic infection or acute in activity;  uncontrolled hypertension (&gt; 160 mmHg systolic or &gt; 100 mmHg diastolic); Use of medications that affect body composition, such as corticosteroids and antiretroviral therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-67wbv3r	Effects of physical exercise associated with laser therapy on functional capacity and muscle performance in individuals with persistent symptoms of Covid-19	Not yet recruiting	Intervention	2022-07-06	<NULL>	<NULL>	5598	Effects of physical exercise associated with photobiomodulation therapy on functional capacity and muscle performance in individuals with persistent symptoms of Covid-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Santa Catarina - Campus Araranguá	Laboratório de Avaliação e Reabilitação do Aparelho Locomotor-LARAL (UFSC/Campus Araranguá)	https://ensaiosclinicos.gov.br/rg/RBR-67wbv3r	<NULL>	Individuals aged between 18 and 70 years, of both genders with musculoskeletal pain, myalgia or arthralgia, persisting after four weeks of Covid-19 infection. Individuals with pain rating equal to or greater than 3 on the Visual Analogue Scale. Individuals classified as grade 1, 2 and 3 on the modified Medical Research Council scale	Individuals with pain rating lower than 3 on the Visual Analogue Scale. Individuals with grades 4 and 5 on the modified Medical Research Council scale. Individuals with chronic pain complaint in the treatment region, prior to Covid-19. Individuals with epilepsy, fibromyalgia, cardiac alterations and decompensated diabetes. Recent surgeries in regions related to the treatment site with less than 3 months; Laser photosensitivity; Continuous use of analgesics, muscle relaxants or anti-inflammatory drugs in the 48 hours prior to the intervention. pregnant women. Individuals with neurological and cognitive dysfunctions, such as dementia, intellectual disability, communicative deficit or any other condition that makes it impossible to understand the study procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-9ykz7ws	Effects of physical exercise associated with motivational techniques in individuals with chronic respiratory disease	Recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7784	Effects of a physical training program associated with behavior change strategies on motivation for physical exercise in individuals with COPD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Departamento de Fisioterapia da Universidade Federal de São Carlos	Departamento de Fisioterapia da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9ykz7ws	<NULL>	Patients of both genders diagnosed with chronic obstructive pulmonary disease - COPD, with a relationship between forced expiratory volume in one second and forced vital capacity less than 0.70; being clinically stable in the last four weeks; under medical follow-up and drug treatment; absence of participation in physical training programs in the last six months; age equal or over fifty years old; functional participants however with exercise capacity assessed by the six minute step test and/or six-minute walk test with values ​​below eighty percent of predicted; without cognitive deficit assessed by the Mini Mental State Examination - MMSE questionnaire; without changes in balance assessed by the short physical performance battery and acceptance to participate in the study	Intentional tremor; treatment of malignant neoplasm; body mass index above thirty five; rheumatic, neuromuscular, orthopedic and visual problems that make it impossible to walk or go up and down steps; unstable cardiovascular and respiratory diseases; and conditions that prevent testing and withdrawal from participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-5m3s2s	Effects of physical exercise associated with music on behavioral, functional and mental aspects in older people with dementia who live in nursing homes	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1800	Behavioral, functional and mental factors and the Effects of Physical Exercise associated with Music in institutionalized older people with Dementia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-27	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5m3s2s	<NULL>	People aged 60 years old and over; living in nursing homes; dementia diagnosis; availability to participate in the proposed evaluations.	Severe and uncorrected auditory disorder that prevents the participant from hearing music; any cardiovascular or infectious comorbity described in the absolut contraindications list of Physical Activity Readiness Medical Examination (2002) (acute infectious disease, dissecting aneurism of aorta, severe aortic stenosis, congestive heart failure, unstable angina, acute myocardical infarction, acute myocarditis, pulmonary or acute systemic embolism, thrombophlebitis, ventricular tachycardia and other dangerous arrhythmias).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7zjgnrx	Effects of Physical Exercise in movements, manual hability and brain plasticity in individuals with Parkinson&apos;s disease	Recruiting	Intervention	2022-09-06	<NULL>	<NULL>	5594	Effects of Physical Exercise in motor function, manual dexterity and brain plasticity in individuals with Parkinson&apos;s disease: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Laboratório de Neurociências - Universidade Federal de São Carlos	Harvard Medical School	https://ensaiosclinicos.gov.br/rg/RBR-7zjgnrx	<NULL>	The inclusion criteria will be age between 40 to 80 years; both genders; diagnosis of Parkinson&apos;s disease as confirmed by neurologist;  stage 1-3 on the Hoeh and Yahr scale; who were not exercising at moderate intensity greater than 3 times per week within 3 months; complaints about motor impairments related to hand function (self-report);  taking stable medications for Parkinson&apos;s disease for at least 30 days	The exclusion criteria will be features suggestive of other causes of parkinsonism/ Parkinson’s-plus syndromes, unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure, uncompensated pulmonary disease, or chronic obstructive pulmonary disease), psychiatric diseases diagnosed by a psychiatrist; dementia (Mini-Mental State Examination score less than 24), presence of another neurological disorder and hearing or visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-6v9sjj	Effects of physical exercise in patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2016-10-19	<NULL>	<NULL>	1045	Effects of elastic resistance training on morphological and functional parameters in patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Universidade Estadual Paulista Júlio Mesquita Filho	Universidade Estadual Paulista Júlio Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6v9sjj	<NULL>	Patients must have a diagnosis of chronic obstructive pulmonary disease; both genders; tifennau index less than 70 percent; be aged between 45 and 70 years; being clinically stable.	Cardiac comorbidities and musculoskeletal disorders; exacerbation within one month of the initial evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-9mwmq2q	Effects of physical exercise in patients with Diabetes Mellitus	Recruitment completed	Intervention	2025-04-03	<NULL>	<NULL>	7883	Efects of metabolic rehabilitation in patients with Diabetes Mellitus: Randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-30	Hospital Estadual Dr. Alberto Rassi	Hospital Estadual Dr. Alberto Rassi	https://ensaiosclinicos.gov.br/rg/RBR-9mwmq2q	<NULL>	Individuals over 40 years of age; with a clinical diagnosis of type 2 diabetes mellitus; of both sexes; with a self-reported sedentary lifestyle or physical activity level of less than 150 minutes per week; who have agreed to and signed the Free and Informed Consent Form	Individuals with clinical instability; osteomyoarticular; neurological diseases; wounds that make it impossible to perform assessments or physical exercises; individuals with lower limb prostheses and/or amputations of the following types: lisfranc, transtibial or transfemoral; individuals with two consecutive absences during the intervention phase or who choose to withdraw their consent to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-6649b2	Effects of physical exercise in the fadigue of the patient with heart and lung disease	Recruiting	Intervention	2020-05-20	<NULL>	<NULL>	3855	Evaluation of fadigue of the patient with heart and lung disease undergoing physical exercise	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-06-02	Universidade Federal do Rio de Janeiro	ICES - Instituto do Coração Edson Saad	https://ensaiosclinicos.gov.br/rg/RBR-6649b2	<NULL>	"Group 1 (COPD): patients in this group will be selected based on the presence of the forced expiratory volume in the first second (FEV1) less than 60% of the predicted; with FEV1 / forced vital capacity (FVC) ratio less than 70%; who have symptoms of dyspnea on clinically stable efforts.
- Group 2 (CHF): patients must have documented heart failure in the last 6 months; with echocardiography showing an ejection fraction of less than 45% within the last 6 months; with classification between I-II of the disease according to New York Heart Association45; clinically stable and without episodes of hospitalization in the last month, non-smokers; non alcoholics; non-drug users who cause chemical dependency; who do not have COPD (FEV1 / FVC and FEV1 &lt;70% of predicted) or unstable angina; or history of myocardial infarction in the last 6 months; or inability to exercise due to neuromuscular or musculoskeletal disorders; as well as other potential causes of fatigue.
- Group 3 (control): volunteers in this group will be selected because they are in good general health; in the absence of abnormalities in the cardiovascular, respiratory or musculoskeletal system and metabolic changes; sedentary (weak classification by the American Heart Association44)"	"Group 1: no absence of hypoxemia, ex-smokers; who do not have right heart failure; non alcoholics; non-drug users who cause chemical dependency; and who do not have an inability to perform the exercise due to neuromuscular or musculoskeletal disorders; as well as other potential causes of fatigue.
Group 2: non-smokers; non alcoholics; non-drug users who cause chemical dependency; who do not have COPD (FEV1 / FVC and FEV1 &lt;70% of predicted) or unstable angina; or history of myocardial infarction in the last 6 months; or inability to exercise due to neuromuscular or musculoskeletal disorders; as well as other potential causes of fatigue.
Group 3: should not be smokers; drinkers; drug users who cause chemical dependency; without diabetes melitus, dyslipidemia and arterial hypertension; non-users of antihypertensive and cardioactive medications."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-5szbt9	Effects of physical exercise in the treatment to stop smoking	Recruiting	Intervention	2018-03-27	<NULL>	<NULL>	2908	Aerobic training effectiveness in functional parameters in cessation of smoking	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-02	Universidade Estadual Paulista - FCT/UNESP	Universidade Estadual Paulista - FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5szbt9	<NULL>	Eligible participants should meet the following inclusion criteria: smoking at least 10 cigarettes / day; age between 18 and 60 years; clinically stable individuals with no change in medications for at least 30 days; desire to stop smoking.	Smokers who have pre-existing chronic cardiorespiratory diseases (arrhythmias, uncontrolled hypertension, chronic cough, chronic bronchitis, pulmonary emphysema or FEV1 / FVC &lt;70%); individuals with pathological conditions that prevent the performance of physical exercise (orthopedic or neurological diseases); individuals with another pathological condition that may influence the systemic inflammatory process (metabolic or rheumatic diseases); use of nicotine replacement drugs and / or antidepressants as an aid in smoking cessation; Alcohol abuse; pregnant women current or intending to become pregnant during the exercise protocol; and participants from another systematic exercise program for at least 20 minutes a day, three days a week for three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-6nhy6h	Effects of physical exercise on cholesterol, glycemia and menstrual cycle of women with micropolicistos in the ovary	Recruitment completed	Intervention	2018-08-27	<NULL>	<NULL>	3648	Brazilian Study on Polycystic Ovarian Syndrome (PCOS)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Departamento de Toco-Ginecologia da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6nhy6h	<NULL>	Age between 18 and 40 years;Body mass index greater than or equal to 18.5 kg / m² and less than 40 kg / m²; Hirsutism, irregular and / or anovulatory menstrual cycles, normal renal and hepatic function;Polycystic appearance of ovaries; No use of medications for at least 3 months; without practicing physical exercises in the last six months or sedentary.	Pregnant women; They present androgen secreting tumors, Cushing&apos;s syndrome, congenital adrenal hyperplasia, hyperprolactinemia (greater than 40 ng / ml) and thyroid dysfunctions; and Diabetes mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-53fx6p	Effects of Physical Exercise on Cognitive and Motor Functions in Alzheimer&apos;s Disease	Data analysis completed	Intervention	2018-04-30	<NULL>	<NULL>	1742	Exercise, Biomarkers and Functionality in Alzheimer&apos;s Disease and in Frailty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-03	Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM	Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-53fx6p	<NULL>	Elderly with clinical diagnosis of Alzheimer&apos;s disease, according to the Diagnostic and Statistical Manual of Mental Disorders; Severity of mild and moderate dementia according to the Dementia Clinical Assessment Score; Availability for participation of the evaluations proposed by the researcher; Elderly persons and their respective caregivers who agree to the study procedures and who agree to sign the Informed Consent Form.	"Elderly patients with coronary heart disease, cardiac arrhythmias, uncontrolled hypertension and angina symptoms, or who have any absolute restriction on physical exercise; Elderly people with visual, auditory, dizzying or other impairments that impair locomotion and balance;
Elderly with other neuropsychiatric conditions;
Frequency less than 70% in the program."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-7bt6dxb	Effects of physical exercise on kidney function, daily living skills and quality of life in people with Chronic Kidney Disease	Recruitment completed	Intervention	2025-01-28	<NULL>	<NULL>	7691	Chronic effects of strength training with blood flow restriction on glomerular function, functional capacity and perceived quality of life in people with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Empresa Brasileira de Serviços Hospitalares - EBSERH	Hospital Universitário Professor Alberto Antunes da Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-7bt6dxb	<NULL>	volunteers with stage 3 chronic kidney disease; both sexes; aged between 35 and 75 years; without a diagnosis of Hepatitis C or B; without flu-like syndromes; without coagulation dysfunction or signs of thrombophlebitis; without severe arrhythmia, angina or cerebrovascular or cardiovascular disease; without pulmonary congestion or peripheral edema; ankle-brachial index within normal standards	volunteers who suffer from any hypokinetic or osteoarticular disease or cardiovascular events during the intervention; medical recommendations to leave the study; attendance of less than 85% of the sessions planned for the intervention; personal needs and wishes to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-5t669rr	Effects of physical exercise on land and in water in adolescents with Congenital Heart Disease	Not yet recruiting	Observational	2026-03-26	<NULL>	<NULL>	9017	Effects of physical training on land and in water in adolescents with Congenital Heart Disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Universidade Estadual de Londrina - UEL	<NULL>	<NULL>	<NULL>	Adolescents between 12 and 20 years of age; of both sexes; diagnosed with Congenital Heart Disease; hemodynamically stable; who have undergone heart surgery; present some residual alteration and do not practice regular physical exercise; do not have a respiratory infection or hospitalization in the last three months; do not use a pacemaker	Moderate to severe arrhythmias; orthopedic or neurological conditions that prevent evaluations and proposed treatment; failure to complete all evaluations or withdrawing from the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-5kq7w75	Effects of Physical Exercise on motor, behavioral and sensory aspects of children with Autism Spectrum Disorder	Recruitment completed	Intervention	2025-09-30	<NULL>	<NULL>	8334	Randomized clinical trial: effects of Physical Exercise on motor, behavioral and sensory aspects of children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5kq7w75	<NULL>	Ages 4 to 6; both sexes; present a report diagnosing the child with Autism Spectrum Disorder, based on the criteria of DSM-5, DSM-5-TR, ICD-10, or ICD-11 with support levels 1 and 2; participate in a maximum of 2 concurrent therapies; must demonstrate minimum comprehension and interaction skills to perform the proposed activities; signature of the child&apos;s informed consent form (TALE); authorization of parents/guardians by signing the informed consent form (TCLE)	With severe intellectual impairment; nonverbal; participating in an intensive motor intervention program; being assisted by an occupational therapist; physical inability to exercise at moderate intensities; children with more than 20% absences from the total number of sessions; refusal to sign the consent form to participate in the study; parents who refuse to sign the consent form to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-7m8d7mp	Effects of physical exercise on muscle control in people with Parkinson&apos;s disease	Recruitment completed	Intervention	2021-06-01	<NULL>	<NULL>	4708	Bone health in Parkinson&apos;s Disease: relationship between aspects of bone fragility, mobility, balance and propensity to fall	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Universidade Federal do Paraná - UFPR	Pontifícia Universidade Católica do Paraná - PUCPR	https://ensaiosclinicos.gov.br/rg/RBR-7m8d7mp	<NULL>	Aged 60 or older, both sexes, diagnosed with idiopathic Parkinson&apos;s Disease (IPD) by a neurologist specializing in Movement Disorders and in stages 1 to 3 on the Hoehn and Yahr scale.	"Participants who presented cognitive deficits evaluated by means of the Mini Mental State Examination (MMSE) or adverse clinical conditions that could impede participation in the proposed protocol were excluded, as well as severe visual impairment, women in the post-menopausal phase, those using Deep Brain Stimulation (DBS), patients participating in some type of stretching activity, muscle strengthening or regular balance training, any motor sequelae that compromised balance and/or difficulty in locomotion, as well as patients restricted to a wheelchair (wheelchair).
Osteometabolic diseases or the use of medications that interfere with bone metabolism, such as corticosteroids and bisphosphonates, were also excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-7hf8jw	Effects of Physical Exercise on muscle mass, strength, and blood markers in HIV Patients	Data analysis completed	Intervention	2018-02-27	<NULL>	<NULL>	2284	"Effects of 16 weeks of Strength Training on muscle mass, strength and
markers of oxidative stress in HIV patients"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	CEFE - Programa de Pós-Graduação em Educação Física UEM/UEL	Hospital Universitário da Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7hf8jw	<NULL>	Be HIV-infected; make regular and correct use of ART for at least 1 year; do not present any motor impairment that affects the performance of tests and training; do not present any severe illness; not having been involved in the last 6 months with any physical exercise program; be older than 18 years.	Are using hormones, anabolic drugs or modulating immune therapy; present state of diarrhea, nausea, vomiting or poor oral intake of food; to present systemic infection in the 30 days before the beginning of the training; present current pregnancy or lactation; present state of advanced immunodeficiency and/or opportunistic infection; present some comorbidity that prevents the practice of exercise training; present any other contraindicated medical to the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-9fnhzqw	Effects of Physical Exercise on Patients Treated with Drugs for Breast Cancer	Not yet recruiting	Intervention	2025-01-28	<NULL>	<NULL>	7689	Effects of Physical Exercise during Chemotherapy in Patients with Breast Cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-02	Bruno Gama Linhares	Faculdade de Medicina de Campos - Fundação Benedito Pereira Nunes	https://ensaiosclinicos.gov.br/rg/RBR-9fnhzqw	<NULL>	Women over 18; histological diagnosis of stage IA-IIIC breast carcinoma; scheduled to receive chemotherapy with anthracyclines or trastuzumab; be able to understand and accept informed consent; breast cancer patients	Contraindications for exercise testing, decompensated comorbidities; pre-existing heart disease, pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-5n53cnv	Effects of Physical Exercise on post-discharge patients by Covid-19	Recruitment completed	Intervention	2022-02-11	<NULL>	<NULL>	5199	Physiological and sensory effects of Cardiopulmonary Rehabilitation based on Physical Exercises in patients post hospital discharge by Covid-19	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Hospital Militar de Área de São Paulo	Hospital Militar de Área de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5n53cnv	<NULL>	Patients after hospital discharge, with a discharge period of ≤ 6 months; infected with COVID-19 confirmed by a molecular test RT-PCR for diagnosis of the SARS-COV-2 virus; of both sexes; aged between 20 and 85 years old and who agree to participate in the research, signing the free and informed consent form.	Patients with ventricular arrhythmias; atrial fibrillation; unstable angina; acute myocardial infarction; with worsening of respiratory symptoms such as dyspnea and worsening of the aspect and or increased volume of bronchial secretion. Patients with musculoskeletal and or neurological alterations that make it impossible to perform tests and physical exercises will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-8vv7yzq	Effects of physical exercise on shoulder recovery and arm swelling in women after breast cancer surgery	Recruitment completed	Intervention	2025-08-26	<NULL>	<NULL>	8231	Physical Exercise as a complementary therapy in the care of individuals with Cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade do Estado de Mato Grosso - UNEMAT	Universidade do Estado de Mato Grosso - UNEMAT	https://ensaiosclinicos.gov.br/rg/RBR-8vv7yzq	<NULL>	Women; aged 18 years or older; without cognitive alterations and able to understand the Informed Consent Form (ICF); diagnosed with breast cancer; undergoing treatment; capable of physical exercises; with a medical certificate for physical activity	Patients with untreated/acute deep vein thrombosis; high fever; blood alterations (platelet/hemoglobin below reference); active bleeding; needing a walking aid; difficulty understanding instructions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-3xsnyd	Effects of Physical Exercise on sugar levels in women with Gestational Diabetes	Terminated	Intervention	2020-08-31	<NULL>	<NULL>	7417	Glycemic responses after the performance of two Aerobic Exercise protocols on women with Gestational Diabetes during hospitalization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Hospital Escola da Universidade Federal de Pelotas	Universidade Federal de Pelotas (UFPel)	https://ensaiosclinicos.gov.br/rg/RBR-3xsnyd	<NULL>	Women at least 18 years old; with diagnosis of Gestational Diabetes Mellitus (GDM) and gestational age up to 37 weeks; use or not of oral hypoglycemic agentes; Body Mass Index (BMI) between 20 and 45 kg/²; physically inactive women (absence of physical exercise for at least 30 minutes on three or more days a week) during the gestational period	Patients on regular use of insulin; presence of type 1 (DM1) or type 2 (DM2) diabetes; infectious diseases; significant loss of kidney or liver function; patients with relative contraindication or absolute  to perform physical exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-9x9kcs6	Effects of physical exercise on the health of people deprived of their liberty	Recruitment completed	Intervention	2024-04-01	<NULL>	<NULL>	6906	Functional Training for penitentiaries and its effects on behaviors associated with health and improved mood	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-16	Universidade Federal de Sergipe	Complexo Penitenciário Dr. Manoel Carvalho Neto	https://ensaiosclinicos.gov.br/rg/RBR-9x9kcs6	<NULL>	Inmates appointed by the prison&apos;s management; age between 18 and 50 years old; male; considered to be of low risk; with at least one year&apos;s imprisonment; who showed interest in taking part in the study	Individuals who were being treated for any illness; had committed crimes classified as heinous; had serious indiscipline in their history; who could compromise the organization and development of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-7r6z2nk	Effects of physical exercise on the health of the heart, blood vessels and muscles in older adults	Not yet recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7258	Effects of exercise training on cardiovascular, functional, metabolic, inflammatory parameters, and body composition of older adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-7r6z2nk	<NULL>	Individuals aged 60 years or older gender both sexes; not participating in any supervised physical training program in the last 6 months; availability to perform physical exercises twice a week; not having undergone recent surgery; not having chronic obstructive pulmonary disease; feeling pain; nor having an orthopedic injury that prevents participation in the experiment; for example, joint instability; dislocation; recent fractures; severe contracture in muscles of the lower limbs	Present nausea; dizziness; discomfort; fainting; or excessive sweating; miss one of the assessments; request to leave the intervention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7b8f2c	Effects of physical exercise programs performed at outdoor fitness gym in hypertensive individuals	Recruitment completed	Intervention	2018-09-05	<NULL>	<NULL>	2178	"Effects of a Physical Exercise Program and
Guidance of Healthy Habits in Hypertensive Patients"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Metodista de Piracicaba - UNIMEP	Universidade Federal de Mato Grosso do Sul (UFMS) - Campus Pantanal	https://ensaiosclinicos.gov.br/rg/RBR-7b8f2c	<NULL>	Inclusion criteria were considered: both genders; age between 40 and 70 years; be hypertensive, according to the VII Arterial Hypertension Guideline (SBC, 2016); have clinical stability, as assessed by the cardiologist and / or clinician and medical certificate for participation in the study.	The exclusion criteria adopted were: to have diabetes and heart diseases; chronic obstructive pulmonary disease and asthma; obesity grade III; musculoskeletal and / or neuromuscular changes, which make it impossible to perform the tests and physical training; some other clinical condition diagnosed after the mandatory exams for inclusion in the program; participation in physical training programs, at the time of screening, in the last six months, and during the study; and absence in three consecutive classes in the training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-82chym	Effects of physical exercise under different levels of effort to prevent atherosclerosis and risk factors in elderly women	Recruitment completed	Intervention	2020-06-03	<NULL>	<NULL>	3908	Effects of high intensity combined training on subclinical atherosclerosis and cardiometabolic factors in elderly women	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2018-08-08	Universidade Federal de Goiás	Instituto Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-82chym	<NULL>	60 years old and 79 years old; signature of the TCLE (according to resolution 466/2012); possibility of regular attendance; sedentary; not be diabetic; without limitations and / or motor disability of any kind.	Body mass index between 24 Kg / m2 and 40 Kg / m2; abdominal circumference greater than 80 cm; estimate of the metabolic equivalent (MET) below 4.5 METS or above 7.5 METS (&lt;15.75 or&gt; 26.25 ml / kg / min of Maximum Oxygen Volume).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-7z5pw7y	Effects of Physical Exercise with Electrical Stimulation on the health of elderly individuals with kidney Issues	Not yet recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8615	Effects of a Physical Exercise protocol with or without Neuromuscular Electrical Stimulation on Dialysis efficiency and functionality in elderly people with Chronic Kidney Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-13	Universidade Comunitária da Região de Chapecó	<NULL>	<NULL>	<NULL>	Older adults of both sexes, aged between 60 and 75 years, undergoing hemodialysis treatment for at least three months, who present hemodynamic and clinical stability confirmed by the following parameters: resting heart rate between 50 and 100 bpm, respiratory rate between 12 and 25 breaths per minute, oxygen saturation greater than 90%, blood pressure between 90/60 mmHg and 160/90 mmHg, and body temperature between 36°C and 37.8°C; laboratory tests performed within the last 30 days showing a minimum hematocrit of 30%, hemoglobin level above 8 g/dL, and platelet count greater than 50,000/mm³; preserved lower-limb muscle strength assessed using the Medical Research Council (MRC) Muscle Strength Scale, with a minimum score of grade 3 for hip flexors, knee extensors, and ankle dorsiflexors; cognitive function will be assessed using the Mini-Mental State Examination (MMSE).	Participants with a diagnosis of cancer or chronic lung disease; those who present musculoskeletal limitations that compromise the execution of the exercise protocol for cycling and strength training or that pose a risk to participant safety, such as in the case of hemodynamically unstable older adults; individuals with a high degree of frailty assessed by the Frailty Scale, without functional independence, using a cutoff point of 5; participants who miss more than three consecutive or alternating sessions; those who present changes in clinical condition that prevent the performance of the physical exercise protocol will have their data excluded from analysis; dialysis fistulas in the lower limbs; very active older adults, assessed using the Short Physical Activity Index (Short IPAQ), to determine the physical activity level of older adults with chronic kidney disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-778wr4	Effects of Physical Exercises in Group and at Home for the Elderly	Recruiting	Intervention	2017-10-02	<NULL>	<NULL>	1663	Effectiveness of a Supervised and Unsupervised Exercise Program for the Elderly: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-15	Universidade do Sagrado Coração	Secretaria Municipal de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-778wr4	<NULL>	Fragile elderly; Age above 60 years; Both sexes; Any level of schooling	Severe cognitive impairment; Severe motor impairment; Severe hearing deficit; Severe vision deficit; Temporary or permanent incapacity to wander; Elderly in the terminal stage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-3nm5bv	Effects of physical exercises in lung cancer individuals	recruiting	Intervention	2011-07-06	<NULL>	<NULL>	13	Impact of pulmonary rehabilitation in the incidence of postoperative respiratory complications in pulmonary resection for lung cancer	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2010-01-01	HOSPITAL DE MESSEJANA DR. CARLOS ALBERTO STUDART GOMES - SESA/CE	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3nm5bv	<NULL>	"Staging of lung cancer among IA, IB, IIA, IIB and IIIA.
Medical Research Council (MRC)dyspnea scale at moderate to severe.
Candidate for pulmonary resection through thoracotomy.
Males and females aged greater than or equal to 38 years and less than or equal to 80 years."	"Severe cardiovascular or other diseases that contraindicate exercise;
Diseases with orthopedic impairments that preclude the exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-4mvzz6	Effects of Physical Exercises with association of cognitive tasks on the mobility, muscle strength, cognition and quality of life of Individuals who suffered Cerebral Vascular Accident	Recruitment completed	Intervention	2018-05-21	<NULL>	<NULL>	2604	"Effects of Physical Exercises associated with increased complexity with Stimulation
in the mobility, muscular strength, cognition and quality of life of Individuals
Post-Stroke"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mvzz6	<NULL>	Post-stroke Volunteers; chronic phase of the disease; more than 6 months after Cerebral Vascular Accident, Territory of lesion in the Middle Cerebral Artery or in the Anterior Cerebral Artery, Cognition equal or superior to 21 points in the cognition score scale Montreal Cognitive Assessment (MoCA), 2 months of non-involvement in exercise programs physicist.	Cardiovascular complication that contraindicates the practice of physical exercises; involvement in other physical exercise programs, performing surgeries to attenuate clinical conditions resulting from stroke, chemical blockages to reduce spasticity, during the study that contraindicated its continuity in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-6kfbtt	Effects of physical therapy during hemodialysis in patients with chronic kidney disease.	Recruiting	Intervention	2019-10-07	<NULL>	<NULL>	3042	Effects of a Respiratory and Motor Physiotherapy Protocol on Chronic Renal Patients During Hemodialysis: Randomized and Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-10	Universidade do Sul de Santa Catarina	Hospital Governador Celso Ramos	https://ensaiosclinicos.gov.br/rg/RBR-6kfbtt	<NULL>	Patients of both sexes; age between 19 and 75 years; diagnosis of chronic kidney disease and who have been on a regular hemodialysis program for at least three months.	Carriers of severe respiratory disease; neurological disease; severe heart disease; amputees; wheelchairs; presence of thrombosis; gastrointestinal bleeding; smokers; patients who perform previous regular physical activity or who perform physiotherapeutic intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-6nb6s76	Effects of physical therapy intervention and health education in the preparation for childbirth of Brazilian pregnant women	Recruiting	Intervention	2021-12-16	<NULL>	<NULL>	5118	Effects of physical therapy intervention and health education in the preparation for childbirth of Brazilian pregnant women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-31	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-6nb6s76	<NULL>	Healthy pregnant women; over 18 years	Pregnant women at risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-3b3m2r	Effects of Physical Therapy on  Temporomandibular Disorder in Patients with Fibromyalgia	Recruitment completed	Intervention	2015-06-07	<NULL>	<NULL>	505	Effects of Physical Therapy on Myogenous Temporomandibular Disorder in Patients with Fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-13	Universidade Federal de São Paulo / Hospital São Paulo	Universidade Federal de São Paulo / Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3b3m2r	<NULL>	Fourteen women between 30 and 60 years old; diagnosed with fibromyalgia; presented pain in the jaw, temples, face, preauricular area and ears at rest or during function  and palpation of three or more of the 20 muscle sites (tendon and temporalis, masseter, submandibular region, the lateral pterygoid area) muscle;   limited mouth opening; visual analogue scale (VAS) between 3 and 7.	internal derangement of the temporomandibular joint, a predominantly mouth breathing pattern, systemic, pulmonary or cardiac musculoskeletal disease and history of trauma to the face or cervical spine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-993dm8	Effects of physical therapy session frequency no rehabilitation of children with congenital Zika Virus Syndrome	Recruiting	Intervention	2018-12-11	<NULL>	<NULL>	2374	Effects of physical therapy on motor function and neurocognitive development of children with congenital Zika virus syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Instituto de Pesquisa Professor Joaquim Amorim Neto	Instituto de Pesquisa Professor Joaquim Amorim Neto	https://ensaiosclinicos.gov.br/rg/RBR-993dm8	<NULL>	Diagnosis of SCZV confirmed by RT-PCR or presumed by imaging findings (gestational ultrasonography and / or transfontanel ultrasonography and / or tomography), and controlled seizures.	Any clinical conditions at the time of data collection that contraindicate physical therapy, such as severe malnutrition, newly performed surgery, pneumonia and other infections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-32gwpm	Effects of physical training and psychological training on performance, physiology and physical and psychological health of elite athletes	Recruitment completed	Intervention	2019-06-26	<NULL>	<NULL>	2789	Effects of physical training and psychological training on performance, physiology and physical and psychological health of elite athletes	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-32gwpm	<NULL>	Federated athlete; to be part of the same volleyball team, to be training and competing regularly; to have no injury or any health problem that could interfere with the result at the beginning of the experiments; to have a regular menstrual cycle.	Absence in training greater than 50%; Absence in interventions greater than 50%; lesion; health problem.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-8nsbprb	Effects of Physical Training associated with Transcranial Direct Current Stimulation on the physical performance of individuals with Chronic Obstructive Pulmonary Disease - COPD	Not yet recruiting	Intervention	2024-05-29	<NULL>	<NULL>	7037	Effects of in-person and remote Physical Training and Transcranial Direct Current Stimulation on the functional, neuromuscular and mechanical performance of individuals with COPD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Instituto de Educação Superior da Paraíba - IESP	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-8nsbprb	<NULL>	Subjects diagnosed with mild or moderate Chronic Obstructive Pulmonary Disease - COPD according to the Global Initiative for Chronic Obstructive Lung Disease criteria (GOLD 1: Forced expiratory volume in the first second (FEV1) mild ≥ 80% of predicted, GOLD 2: 50% moderate ≤ FEV1 &lt;80% of predicted); of both sexes; aged between 45 and 75 years; and classified as sedentary or insufficiently active (International Physical Activity Questionnaire - IPAQ, reduced version)	Individuals with acute exacerbation of Chronic Obstructive Pulmonary Disease - COPD, with unstable hemodynamic parameters (blood pressure &lt;100mmHg systolic and &lt;60mmHg for diastolic and Mean Arterial Pressure (MAP) &lt;80mmHg), who have undergone surgery in the last 6 months; with a recent history of chest wall trauma or abdominal trauma; and/or substantial chest wall deformity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-99xnc6	Effects of physical training associated with word memorization in improving the balance of the elderly	Recruiting	Intervention	2018-09-27	<NULL>	<NULL>	2243	Effects of Cognitive motor training on postural control of the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-99xnc6	<NULL>	Elderly in the community aged 60 years or over; both sexes; functional state capable of remaining in the orthostatic position and walking without assistance; without cognitive impairment Mini Mental State Examination above 18 for illiterate and below 26 for those with educational level above 8 years; normal or corrected auditory acuity through the Whisper Test;normal or corrected visual acuity assessed by the Snellen Test; without prior experience with the Kinect Adventures system games and sign the Free and Informed Consent Form.	Neurological and orthopedic diseases; the inability to remain in a standing position or walk without assistance; cardiorespiratory diseases that result in clinical alterations; angina; cardiac insufficiency; decompensated blood pressure; behavioral alterations that interfere with the development of the study; incapacitating pain; a history of seizures; and missing more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-10fwqmfy	Effects of physical training in aquatic and land environment on type 2 diabetes control	Recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7106	Physical training in different environments, aquatic and land, in the control of Type 2 Diabetes: ALED - Aquatic and Land Exercise for Diabetes - a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-17	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10fwqmfy	<NULL>	The sample will consist of adults and elderly people with type 2 diabetes (T2D), of both sexes, aged between 45 and 80 years. Individuals diagnosed with T2D, through laboratory tests and/or use of hypoglycemic medications, will participate in the sample, following the eligibility criteria: HbA1c levels between 6,5 - 10%, not using exogenous insulin, exempt from regular physical exercise (regular practice of exercise will be defined as performing any type of physical training for at least 20 minutes on two or more days of the week) for at least three months, absence of uncontrolled hypertension, absence of autonomic neuropathy, absence of severe peripheral neuropathy, absence of retinopathy proliferative and severe non-proliferative, absence of uncompensated heart failure, absence of peripheral amputation, absence of chronic renal failure and absence of joint or muscular impairments that prevent physical exercise and body mass index (BMI) ≤ 40 kg/m².	Individuals without confirmed type 2 diabetes, under 45 years of age or over 80 years of age, using exogenous insulin, who are regularly practicing physical exercise, with chronic complications that limit the performance of exercises safely.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-5thjgv	Effects of Physical Training on controlling Blood Pressure, Heart Rate, and Inflammation for post-Stroke individuals	Recruitment completed	Intervention	2017-11-07	<NULL>	<NULL>	1468	Effects of Physical Training on Metabolic, Hemodynamic, Autonomic and Inflammatory Parameters of post-Stroke individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade São Judas Tadeu	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5thjgv	<NULL>	Ischemic Stroke after 6 months; sufficient functional capacity to perform daily activities according to the Barthel Scale; age group between 45 and 85 years; both genders; non-smoker; non-alcoholic; sedentary; have not had recent heart surgery; not having pains that make it impossible to do physical activity; have diabetes mellitus and / or controlled hypertension (s); not have chronic obstructive pulmonary disease; not have an orthopedic injury that makes it impossible to perform exercises.	Orthopedic problems that make it impossible to perform exercises; diabetes and / or uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-6jccqs	Effects of Physical Training on elderly Hypertensive Patients	Recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3205	Effects of Periodized Concurrent Physical Training on hemodynamic and biochemical variables of elderly Hypertensive patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Facudade Estácio de Sergipe - FASE	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-6jccqs	<NULL>	Elderly women; aged 60 to 80; hypertensive stage I and II; sedentary; no target organ damage	Volunteer smokers; history of alcohol or drug abuse; mental disorder; having systolic and diastolic blood pressure above 180 mmHg and 110 mmHg	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-10y6jhrs	Effects of physical training on functional, clinical and psychosocial outcomes of adults and elderly post-infection by Covid-19	Recruitment completed	Intervention	2022-02-22	<NULL>	<NULL>	7077	Effects of physical training on functional, clinical and psychosocial outcomes of adults and elderly post-infection by Covid-19: Covid-19 and rehabilitation study (core-study)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10y6jhrs	<NULL>	Individuals at least six weeks after hospital discharge due to COVID19; Peripheral O2 saturation (SpO2) greater than ninety percent; Normal resting electrocardiogram (twelve leads); Control of underlying diseases (under medical supervision); Ability to sit and stand without assistance; Ability to maintain balance in a standing position; Stable level of consciousness	Severe respiratory symptoms; Tracheostomy devices; Hypersecretion with ineffective coughing; Severe dyspnea; Mental confusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-38xqkw	Effects of physical training on the elderly clinical responses	Recruitment completed	Intervention	2020-03-26	<NULL>	<NULL>	4637	Effects of proprioceptive training and high intensity training intervaled in the clinical answers of elderly: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-30	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-38xqkw	<NULL>	"Age between 60 and 79 years; not be participating in regular physical training programs; absence of cognitive deficit; absence of involvement by limiting cardiovascular diseases for exercise; absence of visual or auditory acuity severely impaired and disabling;
absence of amputations or cutaneous lesions on the feet; independent walking and locomotion without auxiliary devices; Absence of diagnosis of neurological disease that affects the gait pattern."	Elderly women who attend another rehabilitation program during training or in the last three months; those who have less than 75% participation in the proposed training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-497mxmm	Effects of Physical Training on the heart and nervous system of patients attending a cardiac rehabilitation program	Recruiting	Intervention	2023-01-12	<NULL>	<NULL>	5815	Effects of Physical Training on hemodynamic and autonomic responses to Muscle Ergoreflex Activation in patients attending a cardiac rehabilitation program	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-497mxmm	<NULL>	Be aged between 40-70 years. For the groups composed of people with cardiovascular impairment: be enrolled in the cardiac rehabilitation service of Hospital Universitário Pedro Hernesto (HUPE)	For groups composed of people with cardiovascular impairment: practice of regular physical exercises (≥ 3 days/week for 30 min) in the last 6 months; malnutrition; use of antidepressant medication; smoking habit. In addition to the aforementioned criteria, for healthy control subjects, those with a previous or current diagnosis of arterial hypertension; coronary artery disease; heart failure; ischemic disease; pulmonary disease; diabetes mellitus; Chagas disease; tuberculosis; and/or use of antihypertensive medication ill not be considered eligible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-5fgyyzm	Effects of physical training with elastic bands on physical fitness and quality of life of elderly people	Recruitment completed	Intervention	2024-11-28	<NULL>	<NULL>	7545	Effects of resistance training based on elastic bands on functional fitness and quality of life of elderly people: a randomized clinical trial	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-05	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5fgyyzm	<NULL>	Men and women over 65 years of age. Must be able to perform physical activities upon presentation of a medical certificate. Must not have performed regular physical training in the three months prior to the start of the project. Must be available to go to the higher education institution for both the assessments and the 15 intervention sessions	Have uncontrolled cardiovascular diseases or associated complications. Have musculoskeletal problems that prevent the practice of physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-9yyd5v	Effects of Physical Training with Exergames in Sedentary and / or Overweight adolescents	Recruitment completed	Intervention	2020-02-17	<NULL>	<NULL>	3497	Effects of Virtual Reality Training on Sedentary and / or Overweight teenagers	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2019-10-12	Maria Luísa Melo Barbosa	Mércia Lamenha Medeiros	https://ensaiosclinicos.gov.br/rg/RBR-9yyd5v	<NULL>	Sedentary and / or overweight adolescents. Have independent walking. Present preserved cognitive ability.	Hearing loss. Visual deficit. Neuromuscular diseases. Have undergone surgery on lower limbs less than 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-4wx7wp	Effects of Physiotherapy associated to Kangaroo Positioning in Preterm Newborns	Recruiting	Intervention	2019-09-27	<NULL>	<NULL>	6521	Longitudinal repercussions of a Physiotherapeutic Intervention protocol associated to Kangaroo Positioning in Preterm Newborns:randomised clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-02	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4wx7wp	<NULL>	Preterm newborns with corrected gestational age equal to or greater than 34 weeks; with more than 72 hours postnatal life; hospitalized in NICU; with stable clinical condition; with general movements of character poor-repertoire; without need of invasive or non-invasive mechanical ventilation; residents in Campo Grande-MS	Preterm newborns with congenital malformations; chromosomal syndromes; infections in treatment (change in blood count and positive blood culture); severe neurological injury (intracranial hemorrhage grade III or IV and cerebral malformations); neonatal anoxia (Apgar less than 7 in the fifth minute); congenital infection; with other contraindications to receive the physiotherapeutic intervention protocol and kangaroo positioning	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-8m6dt4	Effects of physiotherapy followed by the motor imagery on the mobility of patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2016-05-10	<NULL>	<NULL>	842	Repercussions of motor training followed of mental practice in functional mobility of patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-08	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8m6dt4	<NULL>	Patients with clinical diagnosis of idiopathic Parkinson&apos;s disease; aged between 45 and 75 years; of both sexes; in stage 1-3 of the Hoehn and Yahr scale (HY); they are research volunteers.	Patients with other neurological diseases; patients reporting uncompensated systemic diseases (untreated), such as hypertension; with compromised cognitive level assessed by the Mini-Mental State Examination (MMSE); unsatisfactory motor imagination assessed by questionnaire Visual Imagery and Kinesthetic (KVIQ-20); in physical therapy service for 3 months or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-4tpkszn	Effects of Physiotherapy on immunity in patients with lymphedema	Recruitment completed	Intervention	2022-06-02	<NULL>	<NULL>	5415	Effect of Complex Decongestive Therapy on immune response parameters in individuals with lymphedema	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-09	Fundação de Amparo à Ciência e Tecnologia de Pernambuco (FACEPE)	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4tpkszn	<NULL>	Individuals of both sexes; be over 18 years of age; present lymphedema in lower limbs in stages II or III according to Mowlen (1948)	Patients with lymphedema undergoing treatment with chronic use of oral anti-inflammatory drugs or corticosteroids; with active and untreated infectious processes during study recruitment; who had thrombophlebitis; diabetes; skin rashes; open wounds; urinary and/or fecal incontinence and contraindications for manual lymphatic drainage and for compressive bandaging	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-10sb6573	Effects of physiotherapy on pain and mobility in individuals with temporomandibular dysfunction	Recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9011	Effects of physiotherapeutic treatment on pain modulation and clinical variables in individuals with temporomandibular disorder	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Ciência da Saúde	<NULL>	<NULL>	<NULL>	adults aged 18 years or older; individuals of both sexes; participants recruited from the waiting list for physiotherapy care at the physical therapy teaching clinic of the federal university of paraíba; for the symptomatic group, individuals presenting signs and symptoms of temporomandibular disorders and scoring higher than 2 points on the temporomandibular disorder pain screening instrument (research diagnostic criteria for temporomandibular disorders – rdc/tmd); for the asymptomatic group, individuals without complaints of pain in the temporomandibular joint region and scoring 2 points or less on the temporomandibular disorder pain screening instrument (research diagnostic criteria for temporomandibular disorders – rdc/tmd); asymptomatic participants matched by sex and age with the symptomatic group, considering a maximum variation of three years; individuals who agree to participate in the study and sign the informed consent form	individuals diagnosed with inflammatory arthritis; participants with a history of fractures or dislocations in the facial or cervical regions; individuals with metabolic diseases that may interfere with study outcomes; participants who withdraw from the study after the beginning of the intervention; individuals who miss more than two physiotherapy sessions; participants who develop intercurrent clinical conditions that may compromise assessments or interfere with study results; individuals who present relevant adverse effects related to the intervention; participants who do not agree with or do not adhere to the proposed assessment and treatment procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-3wsdhs	Effects of pilates and aerobic exercise in women undergoing treatment for breast cancer	Recruitment completed	Intervention	2018-01-25	<NULL>	<NULL>	2620	Effects of pilates and aerobic exercise in women undergoing treatment for mammary neoplasia: a control randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-17	Hospital Universitário de Brasília	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-3wsdhs	<NULL>	Women who underwent surgical treatment for breast câncer; as well as axillary lymph node dissection; radiotherapy; chemotherapy and who complain of pain and fatigue.	Women with active câncer; lymphedema; limitation to physical exercise or with limitation to answer some questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-86vp8x	Effects of Pilates in patients with cystic fibrosis	Data analysis completed	Intervention	2014-08-22	<NULL>	<NULL>	329	Analysis of the effects of pilates method associated with respiratory physiotherapy in patients with cystic fibrosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-10	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-86vp8x	<NULL>	Patients between 7 and 20 months of age, both genders, diagnosed with Cystic Fibrosis; presenting forced expiratory volume in one minute (FEV1) above 30% of predicted; with availability to attend the sessions of care.	Patients enrolled in a program of physical activity; presenting Cor Pulmonale severe; presenting twenty-five percent or more absences in the attendance sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-7rbnh6	Effects of Pilates in Sedentary Adults	Recruiting	Intervention	2017-08-15	<NULL>	<NULL>	1333	Influence of Pilates Practice on Physical Composition, Functionality, Body Posture, Life Quality, and Autonomic Modulation in Adults	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7rbnh6	<NULL>	Volunteers of both genders, with technical unfamiliarity with respect to the Pilates Method; to be sedentary; absence of current inflammatory processes derived from musculoskeletal or cardiopulmonary diseases, and absence of previous surgeries on back and abdominal regions.	Presence of some clinical condition at the recruitment moment in order to preclude or to result risk factor to damage or to hurt the volunteer; to use regular medicine which reverberate effects on cardiopulmonary system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-84gg5w	Effects of Pilates Method Breaths on Balance, leg Tiredness, and Routine Activities of Fallers Elderly	Not yet recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1522	Effects of Pilates Method Breaths on balance, lower limb fatigue and functional capacity of fallers elderly: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-20	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-84gg5w	<NULL>	Age greater than or equal to 65 years; Good cognitive status, score greater or equal 17 in the mini-questionnaire questionnaire of mental state; History of falls in the last 12 months; Fear of falling measured by the FES-I-Brazil questionnaire.	Arthroplasty, arthrodesis, or knee, ankle and or hip osteotomy; Those who refuse to participate in data collection; Inability to perform the proposed monopodal balance test and or protocol of intervention; Less than 80% of frequency in sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-7gw699m	Effects of Pilates on Chronic Low Back Pain in employees at a private university	Recruitment completed	Intervention	2024-01-08	<NULL>	<NULL>	6709	Effects of the Pilates Method on Chronic Low Back Pain in employees at a private higher education institution – a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-28	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-7gw699m	<NULL>	Volunteers of both sexes; age between 18 and 50 years old; symptoms of low back pain persisting beyond the acute phase, defined as pain lasting more than 12 weeks or more; pain between 3 and 7 on the 10 cm visual analogue scale	Volunteers who have health problems (cardiovascular, neurological, musculoskeletal impairment or any contraindication to exercising); be carrying out regular training (weight training exercises in the gym, running and other types of training); self-reported functional changes in the lower and upper limbs that prevent the execution of exercises and tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-63j85p	Effects of Pilates Training in Police with Back Pain	Recruitment completed	Intervention	2018-09-20	<NULL>	<NULL>	2220	Effects of Pilates Mat on Police Officers with Non-Specific Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-63j85p	<NULL>	The inclusion criteria establish that the participants must be state military police officers between the ages of eighteen and forty; to present chronic nonspecific low back pain for a period of more than six months; be willing to participate in three weekly sessions of Pilates classes for a period of four months and not present any injury or illness that prevents the performance of the physical tests or any exercise proposed by the Pilates Method intervention program.	The exclusion criteria of the present study include those police officers who do not complete all the pre and post intervention intervention tests; the police officers who do not regularly attend Pilates classes, that is, have twenty percent or more absences; suffer any type of injury, which prevents participation in the proposed tests or continuation of the training sessions and those participants requesting a dismissal of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-87ymt3c	Effects of Pilates training on hypertensive women taking medication	Recruitment completed	Intervention	2025-10-30	<NULL>	<NULL>	8482	Effects of the Pilates Method on hemodynamic, autonomic, endothelial and psychobiological mechanisms of medicated Hypertensive women	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women with hypertension on medication; between 30 and 59 years of age; sedentary; with a body mass index of up to 30 kilos per square meter; not using contraceptives or taking hormone replacement therapy; with medical clearance to practice physical exercise; without osteomyoarticular disease that could compromise the partial or total execution of the proposed exercises; without another disease that could compromise the cardiovascular, respiratory, or metabolic response to exercise; without diabetes mellitus; non-smokers and non-alcoholics; without target organ damage, such as nephropathy, heart disease, etc.; and who agree to be a volunteer for the project	Women with medication changes during the trial period, such as class and dose; with a frequency of less than 75% in training sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:33
RBR-75t8zp	Effects of Pilates Training on Muscle Activity during disturbance in females with chronic low back pain	Data analysis completed	Intervention	2018-08-30	<NULL>	<NULL>	2158	Effect of a pilates training program on postural control of women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-13	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-75t8zp	<NULL>	Participants who did not present: Vestibular problems ie Labirintite; Somatosensory deficiencies such as Diabetic Neuropathy; Neurological problems such as stroke, Parkinson&apos;s, Multiple Sclerosis; Any other type of impairment that could influence permanence in the orthostatic position; Had the consent of a physician to practice the Pilates classes alone; Sign the TCLE; Be between 25 and 55 years of age; Classify as physically inactive or insufficiently active.	People who participated in other physical activities; Women who did not attend Pilates classes regularly; Who became pregnant during the survey period; Have left the license for more than three months for any eventuality; Did not complete all the tests / evaluations of the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-9jwcykc	Effects of Pilates with and without elastic resistance on health variables in postmenopausal women with low back pain	Data analysis completed	Intervention	2021-12-23	<NULL>	<NULL>	5128	Effects of the Pilates method on balance, gait, falls and IGF-1 related to activities of daily living in elderly women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9jwcykc	<NULL>	"postmenopausal woman; present non specific chronic low back pain; low back pain for more than three months;  
no history of engagement in physical exercise during the previous three months"	be on hormone replacement therapy or analgesics; practice other types of exercises or treatments during the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-6yt2hp	Effects of Platelet in the treatment of wounds in patients with Diabetes	Recruiting	Intervention	2020-02-20	<NULL>	<NULL>	3518	Effects of Platelet-Rich Plasma in the treatment of complex wounds in patients with Diabetes Mellitus	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-6yt2hp	<NULL>	Type I Diabetes Mellitus Type II; Chronic wound carrier (over 12 weeks) Both sexes; Age between 30 to 70 years; Controlled blood glucose; Normal peripheral platelet count.	Use of oral anticoagulants, Wound with osteomyelitis and / or with exposure of tendons or bones; Wound with local gangrene or close to the anatomical site. Patients with bleeding tendencies; Uncontrolled DM (HBA1C greater than 7.5); Serum albumin less than 2.5 g / dL; Hemoglobin less than 10.5 mg / dL; Malignant neoplasms; Lupus erythematosus; Pregnancy and lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-54wsdps	Effects of Pneumatic Compression Boot on Recovery after Exercise in Physically Active People	Recruiting	Intervention	2025-04-07	<NULL>	<NULL>	7900	Effects of different Intermittent Pneumatic Compression pressures on indirect markers of Exercise-Induced Muscle Damage in physically active individuals: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-54wsdps	<NULL>	Men aged between 18 and 35 years; classified as physically active according to the International Physical Activity Questionnaire (IPAQ) classification; who do not perform regular jumping training; who have not used Intermittent Pneumatic Compression prior to this research	Subjects with musculoskeletal injuries or lower limb surgeries within a period of nine months prior to the tests; with an inflammatory rheumatological condition or severe cardiovascular and/or pulmonary disease that prevents them from performing the proposed assessment and tests; with any condition that is contraindicated for performing maximum strength tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-9rq7d8t	Effects of Pneumatic Compression, Vibration Therapy, and Photobiomodulation on Muscle Recovery after Muscle Damage	Recruitment completed	Intervention	2025-10-13	<NULL>	<NULL>	8403	Evaluation of the effects of Intermittent Sequential Pneumatic Compression associated with Local Vibration Therapy and Photobiomodulation on muscle recovery after a physical exercise-induced Muscle Damage protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-9rq7d8t	<NULL>	Healthy individuals; of both sexes; between the ages of 20 and 35; who regularly practice physical exercise	Have metabolic; musculoskeletal; cardiovascular; respiratory; or neurological disorders; have recent muscle strains/injuries; be using medications that affect muscles; recently use muscle recovery modalities; undergo ongoing physical therapy; and have allergies to materials	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-6xkcrw	Effects of positioning the newborn on the hammock in the Neonatal Intensive Care Unit to improve pain, stress and development.	Not yet recruiting	Intervention	2019-10-24	<NULL>	<NULL>	3126	Effects of Hammock Positioning in the NICU for pain relief and stress and improvement of motor development	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade do Estado de Santa Catarina	Hospital Sofia Feldman	https://ensaiosclinicos.gov.br/rg/RBR-6xkcrw	<NULL>	preterm newborn (gestational age less than 37 weeks) admitted to the intensive care unit; Low or extremely low birth weight newborn (under 2500g)admitted to the intensive care unit; chronological age greater than 24 hours of life; respiratory and hemodynamic stability; without continuous sedation and / or use of amines.	show signs or symptoms of neurological disorders; malformations; grade 2 or more of peri-intraventricular hemorrhage; severe heart disease; severe respiratory distress, immediate postoperative; phototherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-5bdqznf	Effects of Positive Expiratory Pressure on Airways in Infants with Pneumonia	Not yet recruiting	Intervention	2025-12-23	<NULL>	<NULL>	8678	Effects of Airway Positive Expiratory Pressure (PEP) on Respiratory Distress and Secretion Volume in Hospitalized Infants with Pneumonia: protocol for a randomized, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Ciências da Saúde do Trairi - Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Infants aged between 29 days and 2 years; hospitalized in pediatric wards with a clinical diagnosis of pneumonia; parents or legal guardians accompanying the infants during hospitalization aged 18 years or older	Infants with chronic respiratory conditions; congenital heart disease; malformations of the thoracic cage and or upper airways; associated acute respiratory diseases such as acute viral bronchiolitis, tuberculosis or pertussis; neurological disorders; hemodynamic instability; need for invasive or noninvasive mechanical ventilation at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10b6jdy3	Effects of Post-Exercise Water intake on cardiac contractions in cirrhotic patients	Recruitment completed	Intervention	2023-10-02	<NULL>	<NULL>	7837	Effects of Water Intake on Post-Exercise vagal reactivation in cirrhotic patients	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10b6jdy3	<NULL>	Participants with liver cirrhosis;classified by the Child-Pugh scale A, B and C;over 18 years of age;of both sexes;heart rate in sinus rhythm; and who have performed;hepatic elastography within a maximum time of 12 months from the collection date.	Participants with any musculoskeletal limitation that could interfere with the experimental procedures; patients with a cardiac pacemaker; hyponatremia with values below 142 mEq/L; diagnosis of hepatocellular carcinoma and encephalopathy with a grade equal to or greater than 2; with known respiratory diseases prior to data collection; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-9f8qtqp	Effects of Posterior Crossbite Treatment in children with Aesthetic Aligners and Removable Appliances: a randomized clinical study	Not yet recruiting	Intervention	2025-01-09	<NULL>	<NULL>	7649	Effects of Posterior Crossbite Treatment in mixed dentition with Orthodontic Aligners and Conventional Appliances: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Universidade Anhaguera - UNIDERP	Universidade Anhaguera - UNIDERP	https://ensaiosclinicos.gov.br/rg/RBR-9f8qtqp	<NULL>	Patients in mixed dentition; 7 to 10 years old; both genders; with Angle Class I malocclusion; erupted permanent upper and lower incisors; and unilateral or bilateral posterior crossbite	Patients with craniofacial deformities; absence of permanent teeth; presence of anterior open bite; and previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-4s9zftf	Effects of Pre-exhaustion versus Traditional resistance training on Hypertrophy and Strength in women	Recruitment completed	Intervention	2026-01-29	<NULL>	<NULL>	8814	Effects of Pre-exhaustion versus Traditional resistance training on quadriceps Hypertrophy in women.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-14	Universidade Federal de Pernambuco - Campos Recife	<NULL>	<NULL>	<NULL>	All participants must meet the following requirements: healthy women aged 18 to 35; composed exclusively of women; untrained in resistance training (n=75), which is characterized by the absence of resistance training practice in the last 12 months; no recent history or evidence of abuse of legal or illegal psychoactive drugs; no use of any ergogenic aid (anabolic steroids within the last year; creatine within the last month; caffeine within the last 2 days; beta-alanine within the last 2 days; bicarbonate within the last 2 days; nitrate within the last 7 days)	Participants who withdraw will be excluded; as will those who suffer any type of injury during the data collection period; and participants who answer &quot;YES&quot; to any question on the Physical Activity Readiness Questionnaire (PAR-Q)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-6g7wmqp	Effects of Pre-Load with Hydrolyzed Collagen on Blood Sugar and Health in Patients with Obesity and Diabetes	Not yet recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8558	Acute and Chronic Effects of Hydrolyzed Collagen Pre-load on the Modulation of Glycemia, Hormonal, Inflammatory, and Metabolic Profiles in Patients Living with Obesity and Pre-diabetes or Type 2 Diabetes: A Randomized, Double-Blind Crossover Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	Adults over 18 years of age, able to provide free and informed consent; Diagnosis of Obesity or Overweight and Glycemic Dysregulation: Body Mass Index (BMI) between 25 and 39.9 kg/m² and/or waist circumference &gt; 88 cm for women and &gt; 102 cm for men, and/or Waist-to-Hip Ratio (WHR) &gt; 0.5; Pre-diabetes: Fasting glucose between 100-125 mg/dL OR Glycated Hemoglobin (HbA1c) between 5.7-7.0% OR Oral Glucose Tolerance Test (OGTT) with 2-hour post-load glucose between 140-199 mg/dL, without medication use or only on metformin; Type 2 Diabetes Mellitus (T2DM): Individuals using only stable-dose metformin or lifestyle modifications for glycemic control; Stable weight (fluctuation of ± 3 kg) in the last 3 months before screening	Smokers; Type 1 or Type 2 Diabetes Mellitus using insulin, sulfonylureas, Glucagon-like Peptide-1 agonists, or other antidiabetic medications that could mask the effect of the intervention (except metformin, if included in the inclusion criteria); Glycated Hemoglobin &gt; 8.0%, indicating inadequate glycemic control that would require more intensive pharmacological interventions and could mask the effect of the nutritional intervention; Severe clinical conditions such as chronic kidney disease (stage 3 or higher, estimated glomerular filtration rate &lt; 60 mL/min/1.73m²), significant chronic liver disease (Aspartate Aminotransferase or Alanine Aminotransferase &gt; 3x the upper limit of normal), severe cardiovascular disease (myocardial infarction, stroke in the last 6 months, decompensated heart failure, unstable angina), active inflammatory bowel diseases (Crohn&apos;s Disease, Ulcerative Colitis), autoimmune diseases, except Hashimoto&apos;s, cancer undergoing treatment in the last 5 years; Use of Concomitant Medications: Systemic corticosteroids, medications that significantly affect glucose metabolism or gastrointestinal function (e.g., SGLT2 inhibitors, glitazones, some psychotropics); Collagen supplements, in the 3 months prior to the study; Regular use of laxatives or other supplements (e.g., other high-dose fibers, specific probiotics/prebiotics) that could impact intestinal health or glucose metabolism, and that cannot be discontinued during the study; Antibiotics in the last 3 months before the intervention; Surgical Conditions: History of bariatric surgery or other gastrointestinal surgeries that significantly alter absorption or intestinal transit; Specific Conditions: Pregnancy or breastfeeding, eating disorders (anorexia, bulimia nervosa), alcohol or drug abuse, known allergy or intolerance to any component of the test product or placebo; Inability to Consent: Any physical or mental condition that prevents understanding and providing informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:18
RBR-2qppkbb	Effects of pressure with fingers on points bp6 and ig4 of chinese medicine on pain in pregnant women in a maternity hospital in southern Bahia	Recruitment completed	Intervention	2024-12-20	<NULL>	<NULL>	7617	Effects of acupressure on points bp6 and ig4 on pain in pregnant women at a maternity hospital in southern Bahia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Estadual de Santa Cruz	Hospital Materno Infantil  Dr. Joaquim Sampaio	https://ensaiosclinicos.gov.br/rg/RBR-2qppkbb	<NULL>	Pregnant women over 18 years of age; gestational age from 37 weeks; spontaneous, induced and/or supervised labor; with effective contractions and dilation greater than or equal to 4 cm; with a live fetus, in vertex cephalic presentation and in good vitality conditions; present intact skin bilaterally at the bp6 and ig4 points of traditional Chinese medicine	"Pregnant women who tested positive for COVID-19 less than 14 days ago; presence of obstetric complications or complications such as placenta previa, pre-eclampsia, ruptured membranes, amniotic fluid index 5 cm; dilation greater than 8 cm; immediate indication for cesarean section; 
knowledge of or having used pressure therapy with fingers or needles such as acupuncture, acupressure, doin, shiatsu or reflexology"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-53c3b8	Effects of preventive and therapeutic interventions on the posture of students in the city of Santa Cruz / RN	Recruitment completed	Intervention	2015-01-27	<NULL>	<NULL>	377	Effects of a therapeutic exercise program and education about posture scoliosis posture of schoolchildren in the city of Santa Cruz, RN from the review by photogrammetry and visual assessment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-53c3b8	<NULL>	Children and adolescents aged 7:17 years; both genders; enrolled in elementary or middle school of municipal, state or private schools, urban or rural area, the municipality of Santa Cruz / RN; presenting scoliosis posture after physical therapy evaluation.	Children and adolescents with physical disabilities and / or mental injury and orthopedic, trauma and / or rheumatic preventing the maintenance of orthostatic position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-3dmq83	Effects of probiotic administration in the elderly	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1926	Efficacy of administration of Probiotics in institutionalized elderly	<NULL>	1, single-arm-study, triple-blind	1	<NULL>	<NULL>	<NULL>	2017-07-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3dmq83	<NULL>	- To be 60 years or more; being institutionalized; obtain values between 10 and 24 in the Mini Mental State Examination (MMSE), to exclude individuals with very mild dementias and very severe dementias; be able to walk	-Be less than 60 years; not being institutionalized; obtain value less than 10 and greater than 24 in the Mini Mental State Examination (MMSE); not being able to walk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-59v2yb	Effects of probiotic consumption on gingival inflammation.	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	4324	Effects of probiotic therapy on gingivitis: study of the clinical, microbiological and immunological profile of the host response.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade de São Paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-59v2yb	<NULL>	Systemically healthy individuals; presence of gingival inflammation in more than 30% of the sites; presence of 20 permanent teeth fully erupted, excluding third molars and teeth indicated for extraction; willingness to adhere to the study protocol.	Pregnant or lactating women; individuals with systemic involvement that may interfere with the study results; ingestion of antimicrobials and/or anti-inflammatories in the last 6 months and probiotics or oral antiseptics in the last month; use of medication with gingival implications; history or presence of periodontitis; presence of gingival disease not induced by plaque; known allergies to experimental materials; extensive prosthetic wraps; smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-2kqnj2t	Effects of Probiotic supplementation associated with Tube Feeding on Infections and Blood Sugar control of patients in intensive care unit	Recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6383	Effects of Probiotics supplementation associated with Enteral Nutrition on Infectious Complications and Glucid Metabolism of patients in intensive care: a prospective, randomized, placebo-controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2kqnj2t	<NULL>	ndividuals of both sexes; aged 18 years or older; who are hospitalized in an intensive care unit; who have indication of enteral nutrition via nasogastric, nasoenteral or gastrostomy tube will be included	Individuals who do not present hemodynamic conditions to receive enteral diet, patients with lesions in the gastrointestinal tract that make it impossible to receive enteral diet, patients who are in palliative treatment, who undergo immunosuppressive treatment, who have heart valve prosthesis or valve graft, who have a history of endocarditis, history of rheumatic fever, recent postoperative period of intestinal anastomosis, biliary tract and pancreas surgery, intestinal ischemia, patients with hematological and rheumatological diseases, as recommended by the 2018 Brazilian guideline for nutritional therapy in critically ill patients (BRASPEN, 2018)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-5hnk3r	Effects of Probiotic Supplementation versus Placebo on Intestinal Function in adult women	Recruiting	Intervention	2017-08-24	<NULL>	<NULL>	1345	Effects of Probiotic Supplementation on Intestinal Function in adult women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Mato Grosso	Vitafor©	https://ensaiosclinicos.gov.br/rg/RBR-5hnk3r	<NULL>	"Women between the ages of 20 and 40; who are classified as constipated according to the ROME III criteria are;
Maintain the same diet and routine of daily activities; and sign the Informed Consent Term."	Not to be classified as constipated according to the criteria of ROME III; Not sign the Free and Informed Consent Form; Abstain from treatment for one day; To change their eating routine or exercise during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-3z3w3n	Effects of probiotic use in diabetic patients with periodontal disease	Not yet recruiting	Intervention	2020-05-22	<NULL>	<NULL>	3862	Analysis of the clinical profile of diabetic patients with periodontitis before and after probiotic therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z3w3n	<NULL>	Presence of at least 15 natural teeth, excluding third molars and teeth indicated for extraction; diagnosis of generalized stage III grade C periodontitis, with more than 30% of the sites with probing depth and clinical level of insertion greater than or equal to 4 mm and bleeding on probing of at least 30% of the teeth; presence of type II diabetes mellitus diagnosed at least 5 years ago, with glycated hemoglobin levels between 7% and 11%, treatment with diet and supplementation with insulin or hypoglycemic agents; presence of a good state of general health with the exception of diabetes mellitus.	Presence of other systemic conditions, with the exception of diabetes mellitus, which can affect the progression of periodontitis or the response to its treatment; long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and / or use of antimicrobials in the last 6 months; use of probiotics in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; extensive prosthetic rehabilitation; tobacco consumption in the last 5 years; pregnancy and lactation; diabetic complications, such as nephropathy, neuropathy, and peripheral cardiovascular and vascular diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-9mj2dt	Effects of probiotics consumption for teratment of arterial hypertension	Data analysis completed	Intervention	2020-02-27	<NULL>	<NULL>	3536	Effects of supplementation with Probiatop (mixture of probiotics) in the treatment of arterial hypertension	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2017-08-03	FarmoQuímica	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9mj2dt	<NULL>	women diagnosed with primary systemic arterial hypertension (SAH) and aged 20 to 50 years.	"Age &lt;20 and&gt; 50 years;
Smoking;
Patients with other associated morbidities with the exception of Diabetes Mellitus;
Patients with a history of angina, acute coronary syndrome, changes in
left ventricular ejection fraction;
Patients with changes in liver enzyme levels or kidney failure
(creatinine&gt; 1.5 mg / dL);
Use of medications other than antihypertensives or
hypoglycemics;
Patient undergoing steroid or anticoagulant treatment, using
food supplements, with infections or neoplasia or other chronic pathology
known;
Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-3nx759f	Effects of Probiotics On Reducing Liver Fat in Obese Patients Undergoing Stomach Reduction Surgery	Recruitment completed	Intervention	2021-07-20	<NULL>	<NULL>	4792	Effects of supplementation with Probiotics on improving clinical parameters of individuals with Metabolic Syndrome submitted to Roux-en-Y Gastric Bypass a randomized double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-20	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3nx759f	<NULL>	Obese who will undergo bariatric surgery with non-alcoholic liver steatosis	Failure to use gastric bypass technique in bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:40
RBR-7jw4ry	Effects of probiotics supplementation on risk factors for cardiovascular disease in obese hypertensive individuals	Recruiting	Intervention	2020-01-14	<NULL>	<NULL>	3360	Effects of probiotics supplementation on body adiposity, insulin resistance, lipid profile and blood pressure in obese hypertensive individuals during energy restriction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-20	Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-7jw4ry	<NULL>	Individuals aged 40 to 65 years. Both sexes,  women  in post-menopausal period. Body mass index equal or more than 30.0 and less than 40.0 kg per m². Diagnosis of hypertension on regular treatment with antihypertensive drugs for at least 4 weeks. Signature of the informed consent.	Individuals with evidence of secondary hypertension or presenting blood pressure equal or greater than 160 x 100 mmHg. Diabetes mellitus and or use of insulin or oral hypoglycemic agents. Diagnosis of malignant or autoimmune diseases. Chronic kidney or hepatic diseases. Clinical signs of heart failure or of changes in thyroid function. Use of probiotics, prebiotics, symbiotics, antibiotics, hypolipidemic drugs, hormone replacement therapy, proton pump inhibitors, antioxidant and/or anti-inflammatory supplements including vitamin, mineral or omega 3 in the last 3 months. Recent changes (last 3 months) in body weight (equal or greater than 3kg) and/or in food intake. Current or former smokers (last 12 months). Physical activity practitioners. Vegetarians. Pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-5xs4bp9	Effects of Progressive Muscle Strengthening and Whole Body Vibration in Older Adults with Type II Diabetes	Recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8421	Effects of whole-body vibration combined with progressive resistance exercise on muscle strength, functional capacity, body composition, and biological parameters in older adults with type II diabetes: a single-blind randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-30	Universidade Federal de Minas Gerais	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5xs4bp9	<NULL>	Be 60 years of age or older; have a medical diagnosis of Type II Diabetes; be considered active based on the results of the International Physical Activity Questionnaire; be independent in walking; have signed the free and informed consent form	Type 1 Diabetes; renal and hepatic insufficiency; retinopathy; plantar injuries; previous history of cerebral aneurysm; neurological diseases (Parkinson&apos;s, stroke, traumatic brain injury, spinal cord injuries and multiple sclerosis); cognitive alterations detected in the Mini Mental State Examination (MMSE) (score ≤ 13 for illiterates, ≤ 18 for low and medium and ≤ 26 for high education); current oncological treatment; Present signs of thrombosis; pacemaker wearer;  presence of metal implants;  have orthopedic limitations that prevent training on the platform or tests; recent surgeries or fractures (≤ 4 months); having received whole body vibration treatment in the last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-6frnzp	Effects of prolonged exercise on metabolic changes in insulin, inflammation and oxidation in morbidly obese subjects	Recruitment completed	Intervention	2018-06-05	<NULL>	<NULL>	1871	Effects of chronic physical exercise of moderate intensity on insulin signaling pathways, inflammation and oxidative stress in individuals with morbid obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6frnzp	<NULL>	Adults between 18 and 60 years of both sexes; availability and physical conditions to perform the tests and supervised physical exercises (control group and obese subjects submitted to physical exercise); availability to perform dietary restriction and physical inactivity (obese group submitted only to the restrictive diet) during the study period; inactive for at least 30 days (less than 150 minutes of moderate physical activity per week); no restrictive diet in the last 30 days; no use of medications for weight loss or modulation of body composition for at least 3 months; stable weight at least 3 months	Individuals with or having a first-degree history of cardiovascular diseas; hepatic impairmen; renal impairment; diabetes; thyroid disorders; menopausal women; pregnant women; nursing mothers; smokers; or in continuous use of any medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-2dy25r	Effects of prolonged knee use on fear of individuals with anterior knee pain	Recruitment completed	Intervention	2018-08-01	<NULL>	<NULL>	2464	Effects of the prolonged use of a knee brace on the kinesiophobia of individuals with patellofemoral pain: A randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-2dy25r	<NULL>	Anterior knee pain when performing at least two of the following activities: sitting for prolonged time, squatting, kneeling, running, climbing and descending stairs, jumping and landing; insidious onset symptoms lasting at least 4 months; the worst pain level in the previous month corresponding to at least 3 centimeters in the Visual Analogue Pain Scale (VAS); scores lower than 83 in the Knee Pain Scale (AKPS).	Individuals with a sign or symptoms of any other knee dysfunction; recent history of surgery in any lower limb joint; history of patellar subluxation, clinical evidence of meniscal injury or ligament instability; symptomatic osteoarthritis in any lower limb joint; patellar tendon pathology; referred pain coming from the lumbar spine, hips, ankle or feet; presence of neurological disease; presence of inflammatory process or symptoms of overload; prior physiotherapy treatment for PFP.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-49ngpt	Effects of Prone and Kangaroo Positioning in preterm infants	Data analysis completed	Intervention	2018-10-04	<NULL>	<NULL>	2263	Comparison of the effects of Prone Position and Skin-to-skin contact on cardiopulmonary parameters in premature infants with Bronchopulmonary Dysplasia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-02	Hospital Agamenon Magalhães	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-49ngpt	<NULL>	Premature infants; gestational age range of 25-32 weeks; both genders; with bronchopulmonary dysplasia; cronological age between 28 and 60 days; clinically stable; using nasal cannula or oxyhood up to 40% or room air	Infants with bronchopulmonary dysplasia at invasive or noninvasive support; risk factors for respiratory instability; risk factors for cardiovascular instability; unstable to handling; contact isolation due to infection; mother´s refuse in staying in skin-to-skin contact position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-9k2s42	Effects of protein supplementation and strength exercise on nutritional, metabolic and associated factors in bariatric patients with a further 24 months postoperative	Recruiting	Intervention	2019-05-01	<NULL>	<NULL>	2645	Effects of protein supplementation and resistance training on nutritional, metabolic and associated factors in late postoperative bariatric patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9k2s42	<NULL>	Patients who underwent bariatric surgery (BPYR) for at least 24 months will be included; aged between 18 and 60 years.	Patients with diabetes mellitus, pacemaker, decompensated thyroid dysfunction, or who present in the postoperative period malignant or consumptive disease (neoplasms, AIDS, liver diseases, nephropathies, heart failure and degenerative diseases), psychiatric disorders using psychotropic drugs, chronic use of corticosteroids, hormone therapy or medication for weight loss, presence of amputation and gestation, and patients who were on regular use of the protein supplement for less than 2 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-8r4jpg	Effects of protein supplementation in nutritional status of hemodialysis patients	Data analysis completed	Intervention	2018-04-29	<NULL>	<NULL>	1737	Effects of oral supplementation with albumin in nutritional status of hemodialysis patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Nutrição da Universidade Federal de Goiás	Centro de Nefrologia - Centrel	https://ensaiosclinicos.gov.br/rg/RBR-8r4jpg	<NULL>	The inclusion criteria adopted for participation in the study were: patients of both sexes, aged between 20 and 79 years, for at least three months on hemodialysis treatment, performing three sessions per week.	The exclusion criteria were: bedridden patients; Amputees; Patients with decompensated diabetes; Pregnant women; Who are consuming nutritional supplements containing protein; Food intolerance or allergy to egg white protein; Liver disease, intestinal malabsorption, cancer and Acquired Immunodeficiency Syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-5jbxsf	Effects of protein supplementation in patients with low energy diet for the treatment of weight regain in the late postoperative surgical reduction of the stomach	Not yet recruiting	Intervention	2015-05-11	<NULL>	<NULL>	466	Efects of Metabolic and nutritional protein supplement diet in patients with low energy diet for treatment of weight regain in the late postoperative bariatric surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-07	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5jbxsf	<NULL>	60 patients 18-55 years old, female, undergoing surgery for gastric bypass with surgery in Roux-Y for more than 24 months and who had regained weight of at least 5% of the lowest weight achieved during treatment.	Patients with decompensated diabetes on hormone treatment, with renal or hepatic disease or using any medication for loss weight.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-9q6yb9p	Effects of protein supplementation on body composition of obese women with breast cancer undergoing chemotherapy	Not yet recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7287	Effects of supplementation with isolated whey protein on the body composition of obese women with breast cancer undergoing chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Centro Estadual de Oncologia	Fundação Oswaldo Cruz - Fiocruz Bahia	https://ensaiosclinicos.gov.br/rg/RBR-9q6yb9p	<NULL>	Women; aged &gt;=18 years; diagnosed with invasive breast carcinoma stages I to III; already initiated neoadjuvant or adjuvant systemic chemotherapy treatment; Body Mass Index (BMI) &gt;=30kg/m2	Women diagnosed with associated metastasis; severe obesity (BMI &gt;=40kg/m2); allergy to milk proteins; conditions that affect body water composition such as edema; conditions that affect muscle mass such as muscular dystrophy; limb amputation; pregnancy; use of pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-7nk6g84	Effects of Protein supplementation on body composition, handshake strength  and quality of life of patients undergoing Spine surgery	Recruiting	Intervention	2021-02-02	<NULL>	<NULL>	7135	Effects of Protein supplementation on body composition, handgrip strength and quality of life of patients undergoing Spine surgery: A controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Hospital de Acidentados Clínica Santa Isabel	Centro Estadual de Reabilitação e Readaptação Dr. Henrique Santillo (CRER)	https://ensaiosclinicos.gov.br/rg/RBR-7nk6g84	<NULL>	Patients undergoing lumbar or thoraco- lumbar spine surgery regardless of etiology aged between 50 and 75 years.	Patients with chronic kidney disease with a glomerular filtration rate below 30 ml min; diabetic patients treated with insulin therapy; allergic to milk protein; with malignancy; bedridden previously for diseases not related to spine pathology; with inability to complete quality of life questionnaires; previously submitted to spine surgery; with spinal neurological deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-4zsf45	Effects of pulmonar expansion maneuver on pulmonar complications in children after immediate heart surgery	Recruiting	Intervention	2019-12-10	<NULL>	<NULL>	3264	Effects of alveolar recruitment maneuver on complications pulmonary disorders in children in the immediate postoperative Congenital Heart Diseases: A Randomized Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-11	Hospital martagão gesteira	Hospital martagão gesteira	https://ensaiosclinicos.gov.br/rg/RBR-4zsf45	<NULL>	All children between 6 months and 6 years, who have had cardiac surgery of congenital heart disease with median sternotomy who have been admitted to mechanical ventilation and remain on the ventilator during the proposed intervention period will be included.	Children with hemodynamic instability, such as hypotension, psychomotor agitation, previous pneumonectomy, bronchopleural fistulas, hemoptysis, non-drained pneumothorax, and hypertension will be excluded if they present with a chest deformity, difficulty or inability to swallow and release airways that do not present cough reflex, intracranial. In addition, children with neuromuscular diseases will be excluded; children who have suffered neurological complications during the postoperative period; children who develop dependence on MV and still need to be transferred from the ICU of Martagão Gesteira Hospital.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8tv29dc	Effects of Pulmonary Rehabilitation on the perception of happiness in individuals with Chronic Obstructive Pulmonary Disease	Recruitment completed	Intervention	2023-08-22	<NULL>	<NULL>	7596	Effects of Pulmonary Rehabilitation on the degree of happiness of patients with Chronic Obstructive Pulmonary Disease compared to usual care: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8tv29dc	<NULL>	Individuals with a diagnosis of Chronic Obstructive Pulmonary Disease (COPD); without any other respiratory diseases; of both sexes; aged 18 years or older; clinically stable; without unstable cardiovascular diseases; without neurological disorders; without musculoskeletal diseases; and capable of undergoing the proposed assessments and interventions	Individuals who experience respiratory, cardiovascular, or musculoskeletal complications during assessments and interventions; exacerbation of pulmonary disease; the need for hospitalization; individuals who express their desire to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-99gyq8	Effects of pulmonary rehabilitation-associated melatonin hormone on sensation of difficulty breathing, respiratory muscle strength, ability to perform daily living activities and sleep quality in individuals with chronic lung disease	Not yet recruiting	Intervention	2019-09-24	<NULL>	<NULL>	2989	Effects of pulmonary rehabilitation-associated melatonin on dyspnea, respiratory muscle strength, functional capacity, and sleep quality in individuals with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-03	Universidade Federal do Ceará Programa de Pós Graduação em Ciencias Médicas	Centro Universitário Estácio do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-99gyq8	<NULL>	Selection criteria for rehabilitation program will includ patients from the Pulmonology Service of the WCUH-FUC; of both sexes; above 18 years; with medical diagnosis of Chronic obstructive pulmonary disease based on the Global obsctructive lung disease guideline; stability with no exacerbations or worsening of respiratory symptoms; no increased use of rescue medication and ability to mobilize independently	The exclusion criteria for rehabilitation program will be the patient will submit to exacerbation of Chronic obstructive pulmonary disease; orthopedic or neurologic impairment that might render the subjects incapable of completing the exercise training; patients who not continue rehabilitation for 12 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-7b5hhk	Effects of pumpkin (Cucurbita ficifolia Bouché) in lipid and glycemic profile of type 2 diabetics individuals: a randomized double blinded clinical trial	Data analysis completed	Intervention	2016-08-23	<NULL>	<NULL>	968	In vivo evaluation and monitoring with nanosensors effect hypoglycemic of cucurbita ficifolia Bouché in type 2 diabetic patients	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2012-11-05	Embrapa Hortaliças	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7b5hhk	<NULL>	Individuals diagnosed with pre-diabetes (&gt; 100 to &lt; 125 mg/dL) and individuals diagnosed with type 2 diabetes mellitus (&gt; 126 to &lt; 300 mg/dL).	Individuals diagnosed with Type 2 diabetes for over 6 months with blood glucose &gt; 300 mg/dL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-8qjvkd	Effects of race and aquatic physical function in the detraining, muscular strength and body fat in overweight individuals	Recruitment completed	Intervention	2017-05-18	<NULL>	<NULL>	1236	Effects of deep water running and training in functional capacity, muscle resistance and body composition in pre-obese and obese: pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-06	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-8qjvkd	<NULL>	Participants volunteers, of both genders, adults ranging from 39 to 59 years of age, with pre-obesity and obesity I.	Volunteers cardiorespiratory, musculoskeletal and neuromuscular diseases that impede the performance of the aquatic training program, as well as hydrophobia, skin wounds and infectious-contagious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-6wpdvjk	Effects of radiofrequency and microneedling on the quality of life in women with white marks	Data analysis completed	Intervention	2022-01-13	<NULL>	<NULL>	5145	Effects of radiofrequency and microneedling on the quality of life in women with alba stretches	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6wpdvjk	<NULL>	Volunteers in good health; who did not have severe circulatory or healing problems; who had not undergone any treatment for the dysfunction in the past 6 months	Volunteers who were being treated with photosensitive drugs, anti-inflammatory drugs, antibiotics, immunosuppressive drugs; with suspicion or pregnancy plans; who have used retinoids in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-65hhc4n	Effects of radiofrequency associated with manual lymphatic drainage and vibrating platform to reduce cellulite	Data analysis completed	Intervention	2021-02-08	<NULL>	<NULL>	4519	Effects of radiofrequency associated with manual lymphatic drainage and vibrating platform on the improvement of fibroid edema	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-65hhc4n	<NULL>	Age between 20 and 25 years, Ginoid Hydrolipodystrophy in grades I or II, availability to participate in the interventions (twice a week), phototype II, III and IV according to the Fitzpatrick classification and body mass index (BMI) between 18, 5 and 24.9	Having obesity, smoking, cardiovascular and metabolic diseases, difficulties in understanding simple verbal command, performing physical activity frequently, having a diagnosis of some neurological sequel and some level of lower limb amputation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-2z3ps4	Effects of recreational football on bone, body fat, strength, agility, walking speed, short-term memory and the ability to think fast in the elderly	Not yet recruiting	Intervention	2017-11-17	<NULL>	<NULL>	1484	Effects of recreational football on body composition, physical abilities and executive functions in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	universidade federal de pernambuco	universidade federal de pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2z3ps4	<NULL>	"Individuals male and female;
Age between 60 and 79 years;
Carriers of controlled hypertension;
Individuals classified as sedentary;
To present a higher score than the criteria established in the test Mini Mental State Examination"	"Absolute contraindication for performing physical exercises.
Living outside the metropolitan area of Recife.
Have some physical amputation that limits exercise"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-7rrrvjw	Effects of recreational Volleyball program in Obese adolescents	Not yet recruiting	Intervention	2025-04-02	<NULL>	<NULL>	7880	Effects of a 12-week recreational Volleyball program in Obese adolescents: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Instituto de Educação Física e Esportes	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7rrrvjw	<NULL>	Be between 12 and 17 years old; both genders; display body mass index &gt; 2 standard deviations above the specific for the age and se according to the World Health Organization reference medians; be in the final stages of the pubertal maturation	Have medical conditions that contraindicate participation in physical activities; the use of medication that influences the results observed; participation in structured exercise, nutrition or weight loss programs weight in the 6 months prior to the initial screening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-97htg84	Effects of Red Propolis Dry Extract Supplementation in Patients with Metabolic Syndrome	Recruiting	Intervention	2023-08-22	<NULL>	<NULL>	6370	Effects of Red Propolis Dry Extract Supplementation on biochemical blood parameters in patients with Metabolic Syndrome: a randomized, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-17	Centro Universitário Cesmac	Centro Universitário Cesmac	https://ensaiosclinicos.gov.br/rg/RBR-97htg84	<NULL>	Adults of either sex who have at least three of the five following items: waist above 102 cm in men and above 88 cm in women; triglycerides above 150mg/dL; HDL cholesterol below 40 mg/dL for men and below 50 mg/dL for women; blood pressure above 130/85 mmHg; fasting blood glucose above 110 mg/dL	Pregnant women; lactating women; allergic to any component of the supplement dry extract of red propolis; cancer patients; chronic renal patients; psychiatric patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-3v27w3s	Effects of regular, supervised weight-bearing exercise on muscle strength, control of glucose, triglyceride and cholesterol values and how this type of exercise relates to the amount of the hormone irisin in women with Type 2 Diabetes who have stopped menstruating of more than one year	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4978	Effects of Supervised Resistance Training on Muscle Strength, Metabolic Control, Quality of Life and its relation with Irisin in Postmenopausal Type 2 Diabetic women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Faculdade de Ciências Médicas de Pernambuco	PPGCS/UPE - Programa de Pós-Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3v27w3s	<NULL>	Female patients; in the postmenopausal period; diagnosed with type 2 diabetes mellitus; with variations in glycosylated hemoglobin levels less than or equal to 11%; and are classified as being sedentary or irregularly active according to the International Physical Activity Questionnaire.	Past coronary or cerebrovascular event; carriers of chronic kidney disease with an estimated glomerular filtration rate less than or equal to 30 ml / min; orthopedic limitation for physical exercise; proliferative diabetic retinopathy; disabling diabetic neuropathy; NYHA class III or IV heart failure; established liver disease Child B or C classification; decompensated thyroid disease; malignant neoplasm, except for basal cell carcinoma; in coronary, carotid or peripheral arterial revascularization schedule; documented myocardial ischemia; classified as active or very active by the International Physical Activity Questionnaire; participation in any training program using weights in the last 6 months; and with adherence to the systematic resistance training protocol below 80%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-77npcd8	Effects of rehabilitation using Nintendo Wii® combined with conventional exercises for upper limbs and cognition in patients with Multiple Sclerosis	Recruiting	Intervention	2024-06-25	<NULL>	<NULL>	7096	Effects of Nintendo Wii® training combined with conventional training on upper limb performance and cognition in patients with Multiple Sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade de Brasília	Secretaria de saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-77npcd8	<NULL>	Inclusion criteria will be age under 75 and over 18 years old; diagnosis of Multiple Sclerosis confirmed by a neurologist according to the McDonald criteria, with more than two years of evolution; a score between 3.5 and 6.5 on the Expanded Kurtzke Disability Status Scale (EDSS); no outbreaks in the last 6 months, before the start of the study; presence of mild to moderate cognitive impairment with a minimum score of 18 points on the Montreal Cognitive Assessment; absence of depression, considering the Beck Depression Inventory test, with a score of up to 13 points.	Exclusion criteria will be the presence of illnesses such as psychiatric, other neurological diseases or musculoskeletal disorders that may impede training; be using a course of steroids, whether orally or intravenously, in the last six months prior to the evaluation; be undergoing treatment with botulinum toxin on the date the clinical trial begins or in the six months before the start of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-9x9kctn	Effects of Repetitive Transcranial Magnetic Stimulation (rEMT) in Obesity	Recruiting	Intervention	2023-12-07	<NULL>	<NULL>	6635	Effects of Repetitive Transcranial Magnetic Stimulation (rEMT) on subjective signs of hunger and satiety in Obesity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-17	Instituto de Neuromodulação e Reabilitação Avançada (INERVA)	Instituto de Neuromodulação e Reabilitação Avançada (INERVA)	https://ensaiosclinicos.gov.br/rg/RBR-9x9kctn	<NULL>	Adult volunteers; 18 to 59 years of age; of both sexes; diagnosed with obesity to any degree for body mass index (BMI)	Eutrophic, overweight and malnourished volunteers for BMI; who have contraindications to rEMT or have received rEMT in the last 12 months; who present any head injury, previously documented epilepsy, presence of psychiatric disorder (schizophrenia and bipolar disorder); who have metal implants in their heads; who use or have used anti-obesity drugs (sibutramine, topiramate, orlistat and liraglutide) in the last 3 months; who are addicted to illicit drugs in the last 5 years; who have Cushing&apos;s Syndrome; who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-43vvkt	Effects of resistance exercise  in elderly with sarcopenia	Recruiting	Intervention	2019-12-18	<NULL>	<NULL>	3297	Effects of resistance exercise  on biochemical, physiological, cognitive and behavioral parameters in elderly with different  sarcopenia levels	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-14	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-43vvkt	<NULL>	individuals of both sexes aged 65 to 80 years old;do not use drugs that induce myopathy or food control;not participate in any regular exercise program in the last 3 months;present medical clearance for physical exercise	"Have physical limitations, or diseases that compromise the practice of physical exercise;to present cardiovascular diseases with associated complications that prevent the practice of physical exercise;present severe psychiatric illness (major depression);present neurological diseases: stroke ,  transient ischemic accident, head injury, Parkinson&apos;s and Alzheimer&apos;s disease; intake of anti-inflammatory drugs, erythropoietin and acetylcholinesterase inhibitors
drug addiction ,alcoholism and illicit drugs
communication and visual impairment that prevent the practice of physical exercise
exhibiting vertigo;any osteomioarticular injury during the intervention period"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-25s7pvd	Effects of Resistance Training and the menstrual cycle on muscle mass	Recruitment completed	Intervention	2022-09-22	<NULL>	<NULL>	5629	Effects of Resistance Training and menstrual cycle phase on muscle mass	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-07	Universidade Federal de São Carlos	Laboratório de Adaptações Neuromusculares	https://ensaiosclinicos.gov.br/rg/RBR-25s7pvd	<NULL>	Healthy younger women; age between 18 and 35 years; regular menstrual cycle lasting 21 to 35 days	Regular practice of physical activities; irregular menstrual cycles; anovulatory cycles; cycles with luteal deficiency; any kind of hormonal treatment; endocrine disorders or disorders involving the menstrual cycle; any injury that prevents the practice of physical activity; treatment with drugs that alter body composition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-8xg74vp	Effects of resistance training in Systemic Sclerosis	Recruiting	Intervention	2024-01-30	<NULL>	<NULL>	6759	Effects of lower limbs resistance training on strength, muscle mass and physical function in Systemics Sclerosis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-15	Hospital de Clínicas de Porto Alegre	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-8xg74vp	<NULL>	Women; minimum age 45 years; diagnosis of Systemic Sclerosis according to the American College of Rheumatology	Overlapping autoimmune diseases, except sjögren syndrom; use of ergogenic resources; uncontrolled heart or circulatory disease; palpitation; pulmonary artery systolic pressure (PASP) &gt; 35mmHg; forced vital capacity (FVC) &lt; 70% of estimated; inability to adhere to home-based training; inability to understand and sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-9vqsdx	Effects of resistance training on blood pressure and other cardiovascular risk factors in hypertensive women	Recruitment completed	Intervention	2020-04-09	<NULL>	<NULL>	3725	Acute and chronic effects of different types of resistance training on blood pressure and other cardiovascular risk factors in hypertensive women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9vqsdx	<NULL>	Hypertensive women over the age of 45, enrollment and multidisciplinary treatment at the Hypertension League of Hospital das Clínicas, Federal University of Goiás in a minimum period of six months; not participating in exercise programs for minimum of twelve months; controlled and stable blood pressure with no change in medication in a previous minimum period of six months; able to practice regular physical exercise.	Recent myocardial infarction for less than six months; recent stroke; congestive heart failure; chronic renal failure; decompensated diabetes, untreated and severely neuromuscular, musculoskeletal or joint diseases and any other disease or limitation that could compromise the performance of physical exercise protocols; Body mass index greater than 30 kilograms per meter squared; appearance of arrhythmias and or ischemic changes identified in the cardiovascular test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-6gdyvz	Effects of Resistance Training on Cardiovascular Risk Factors in Middle Aged Women	recruiting	Intervention	2012-12-12	<NULL>	<NULL>	99	Effects of Different Models of Undulating Periodization of Resistance Training on Cardiovascular Risk Parameters, Body Composition, Muscle Strength and Lifespam in Premenopausal Women with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-10	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6gdyvz	<NULL>	To be pre-menopausal aged between 18-49 years and no regular practice of exercise in the previous 12 months	Use of drugs that could affect cardiovascular response to exercise and presence of any disease that would compromise their health during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-9pbq9fg	Effects of resistance training on Fibromyalgia	Recruiting	Intervention	2022-10-06	<NULL>	<NULL>	7085	Effects of the progressive intensity resistance training on Fibromyalgia impact: a blinded randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-9pbq9fg	<NULL>	Male and female patients; aged between 20 and 55; diagnosis of fibromyalgia based on the recommendations of the American College of Rheumatology	Neurological conditions that interfere with assessments; joint diseases at advanced levels; suspected thrombosis; heart disease; pregnancy; abuse of alcohol and illicit substances; active cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-2p4gpvk	Effects of Resistance Training on Heart Rate Variability and Functional Functional Capacity in Menopaused women: a randomized clinical trial	Recruitment completed	Intervention	2022-11-09	<NULL>	<NULL>	5715	Effect of Resistance Training on Heart Rate Variability, Health Parameters, Functional Parameters and Cognitive Parameters in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-22	Victor Silveira Coswig	Programa de pós-graduação em ciências do Movimento Humano	https://ensaiosclinicos.gov.br/rg/RBR-2p4gpvk	<NULL>	untrained women; declare postmenopausal for &gt; 1 year	Osteoarticular diseases; history of alcohol consumption or smoking; fail to complete assessments; fail to complete eight meetings during the 6-month period of the protocol; suffer an adverse event during the intervention; present any chronic or acute condition that may compromise performance during the research; have performed any resistance training program in the last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-3ktg93	Effects of Resistance Training on quality of life, mood disorders, spinal curvature, fatigue indicators and muscle performance in breast Cancer survivors	Recruitment completed	Intervention	2019-02-01	<NULL>	<NULL>	2462	Effects of Resistance Training on quality of life, mood disorders, spinal curvature, fatigue indicators and muscle performance in breast Cancer survivors	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3ktg93	<NULL>	To be between the ages of 40 and 70; to be in the menopause; to have completed all the therapies related to the treatment of the cancer, including, surgery, radiotherapy and chemotherapy; to be at least six months after treatment; to have medical release for physical exercise; and to be performing the treatment of hormonal therapy (Tamoxifeno® or Anastrazol).	To present a diagnosis of lymphedema; uncontrolled arterial hypertension, uncontrolled cardiovascular diseases, uncontrolled neurological diseases and / or orthopedic limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-55wqx58	Effects of resistance training on the rehabilitation of athletes submitted to anterior cruciate ligament surgery	Not yet recruiting	Intervention	2022-03-10	<NULL>	<NULL>	5269	Effects of Resistance Training Periodisation on the Rehabilitations of athletes submitted to Anterior Cruciate Ligament: A randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-55wqx58	<NULL>	Male participants; Age between 18 and 40 years; Patients who underwent anterior cruciate ligament reconstruction;	Regular use of analgesics and/or anti-inflammatory drugs and food supplements; Grade III injury of the medial or lateral collateral ligament; Presence of grade IV chondropathy; meniscal suture; Meniscal injury that requires meniscectomy of a portion greater than 50% of the meniscus; Extra-articular tenodesis; Not wishing to return to sport; Previous knee, hip or ankle surgery; Posterolateral corner injury;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-395mfw	Effects of Resistance Training with Blood Flow Restriction on muscle strength, mass, and quality of life of Cirrhotic patients	Recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2232	Resistance Training with Blood Flow Restriction in Cirrhotic patients: effects on strength, muscle mass, functionality and quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-17	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Cleiton Augusto Libardi	https://ensaiosclinicos.gov.br/rg/RBR-395mfw	<NULL>	Liver cirrhosis confirmed through histopathological assessment, hepatic elastography, or clinical, radiological or endoscopic criteria	Active alcohol intake in the previous 6 month; MELD score above 15; Child-Pugh class C; decompensated chronic diseases; diabetes mellitus; hepatocellular carcinoma or other neoplasms; previous liver transplantation;  severe ascites; persistent hepatic encephalopathy; clotting disorders characterized by INR superior to 1.5 or platelets inferior to 75,000; medical contraindication exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-3mj5vhs	Effects of resistance training with blood flow restriction on pain reduction, physical function improvement, and quality of life in patients with fibromyalgia	Not yet recruiting	Intervention	2025-01-13	<NULL>	<NULL>	7653	Effects of blood flow restriction strength training on clinical, functional markers, and quality of life in patients with fibromyalgia: a randomized, double-blind, sham-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Ciências da Saúde da Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3mj5vhs	<NULL>	Individuals diagnosed with fibromyalgia by a rheumatologist according to the American College of Rheumatology criteria (2010); female; Aged between 20 and 59 years; not engaged in strength training for at least 6 months; physically active; absence of cardiovascular, neurological, or psychiatric disease; ankle-Brachial Index (ABI) between 0.90 and 1.40, not indicating peripheral arterial disease; score above 3 on the visual analog scale	Undergoing any concomitant treatment during the study protocol, such as engaging in physical exercise, changes in medication treatment, and complementary therapies; minimum attendance of 80% in the training program; worsening of disease symptoms during the experimental period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-2h8vyrz	Effects of Respiratory Exercise on Respiratory muscle strength and lung volumes in patients with Chronic Kidney Disease in the Non-Dialysis Stage: a randomized clinical trial	Recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8342	Effects of Progressive Inspiratory Muscle Training on respiratory muscle strength and lung volume variation in patients with Chronic Kidney Disease in the Non-Dialysis Stage: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-09	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2h8vyrz	<NULL>	Patients over 18 years of age, of both sexes, diagnosed with chronic kidney disease on non-dialysis treatment (stage 3 to 5 non-dialysis) with cognitive capacity to perform evaluative procedures and stable from a clinical and hemodynamic point of view will be included	Individuals who have respiratory diseases that alter pulmonary mechanics (asthma, chronic obstructive pulmonary disease, bronchiectasis, history of tuberculosis), are presenting with an active stage infectious disease, and decompensated heart disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-3wss27	Effects of Respiratory Muscle Training in Heart Disease and Sleep Apneia	Recruiting	Intervention	2018-01-18	<NULL>	<NULL>	1575	Effects of Inspiratory Muscle Training in patients with Chronic Heart Failure and Sleep Apneia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-30	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Ciências da Saúde da Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3wss27	<NULL>	Volunteers with left ventricular ejection fraction&gt; 50%; functional classification of I to III of the disease, according to the New York Heart Association (NYHA); both genders ; aged between 30 and 75 years;  non-smokers; non-alcoholic; without chronic obstructive pulmonary disease (FEV1 / FVC&gt; 70% and FEV1&gt; 70% predicted); diagnosed sleep apnea (central apnea / hypopnea index greater than or equal to 5 per hour).	Volunteers with unstable angina; myocardial infarction in the last six months; osteomioarticular, rheumatic and cognitive diseases; systemic arterial hypertension and uncontrolled diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-6vfwnx	Effects of respiratory muscle training on functional capacity in neurological patients	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3664	Effect of respiratory muscle training on functional capacity in individuals with Parkinson&apos;s disease or post stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-30	Universidade Federal da Bahia	Cnetro Universitário Social da Bahia UNISBA	https://ensaiosclinicos.gov.br/rg/RBR-6vfwnx	<NULL>	Age greater than 18 years; confirmed medical diagnosis of Parkinson&apos;s disease with a degree of severity between 1 and 3 according to the HOEHN &amp; YAHR classification or stroke diagnosed six months ago; ability to understand and perform respiratory maneuvers with appropriate technique; absence of pulmonary or neuromuscular disease; except Parkinson&apos;s disease.	Will not be included in the study, individuals who present cognitive alterations according to the Mini Mental State Examination, observing the following score; if illiterate; score less than 19 points; with 1 to 3 years of schooling; score below 23 points; with 4 to 7 years of schooling; score below 24 points, and above 7 years of schooling; score less than 28 points. They present osteomioarticular lesions that make physical activity impossible; chronic uncontrolled diseases such as hypertension; diabetes mellitus and chronic pain. Unstable cardiovascular diseases such as acute heart failure; recent myocardial infarction; unstable angina and uncontrolled arrhythmias. Lung or other diseases that adversely affect the respiratory pump, including asthma and chronic obstructive pulmonary disease. Use of alcohol and other toxic substances; have facial paralysis or difficulty in sealing the mouthpiece during training. In addition to the aforementioned criteria; participants will be excluded in cases of absences exceeding three at the end of eight weeks of treatment; present osteomioarticular or cardiovascular changes acquired during the treatment period that make physical activity and / or inspiratory muscle training impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-6dv5kj	Effects of respiratory muscle training on pulmonary and respiratory muscle function, cardiac function and function of individuals with Parkinson&apos;s disease	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1890	Effects of inspiratory muscle training on pulmonary and respiratory muscle function, autonomic heart function and functional capacity of individuals with Parkinson&apos;s disease: a controled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6dv5kj	<NULL>	"Individuals with idiopathic PD diagnosed previously by a neurologist physician;
Aged 50-65 years; 
Classified in stages I to III of the modified Hoehn and Yahr Scale; 
Ability to walk independently."	"History of chronic or acute non-controlled cardiovascular and respiratory diseases; 
Individuals with cognitive; 
Another neurological disease; 
Change of medication."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8m62y2	Effects of respiratory muscle training on the quality of life of hemodialysis patients	Recruiting	Intervention	2020-06-26	<NULL>	<NULL>	3956	Effects of powerbreathe® on hemodialysis quality of life: blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-8m62y2	<NULL>	"Adult subjects between 18 and 70 years old;
Regular hemodialysis at least 3x a week for at least 6 months;
Do not practice any type of physical exercise;
Having signed the informed consent form (ICF)."	"Uncontrolled systemic arterial hypertension (SAH);
Ischemic heart disease;
Amputation;
Deep vein thrombosis;
Severe dyspnea;
Femoral fistula;
Chronic obstructive pulmonary disease (COPD) stage 3 (severe);
decompensated congestive heart failure (CHF);
Cardiac arrhythmia;
Severe pneumopathy;
Acute systemic infection;
Pregnancy;
Decompensated diabetes mellitus;
Any orthopedic, neurological or cognitive impairment that compromises the understanding and execution of kinesiotherapy programs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-8qwnjg	Effects of Respiratory Physiotherapy in individuals with Kidney Disease	Not yet recruiting	Intervention	2019-11-06	<NULL>	<NULL>	3167	Effects of Respiratory Muscle Training and Peripheral in the physical fitness of individuals with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Universidade Metodista de Piracicana	Universidade Metodista de Piracicana	https://ensaiosclinicos.gov.br/rg/RBR-8qwnjg	<NULL>	Will be included participants from 20 to 69 years, who have stage V (five) CKD; HD treatment for at least three months, three times a week; with hemodynamic stability; able to perform the evaluations and proposed training and agree to participate in the study.	Obese individuals (BMI Bigger or equal 30Kg / m2) who have a history of lung disease, decompensated heart disease, musculoskeletal and / or neuromuscular disorders that preclude the test will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-86tszx	Effects of Respiratory Physiotherapy techniques on Preterm Newborns	Recruitment completed	Intervention	2020-06-15	<NULL>	<NULL>	3923	Comparison between the Thoraco-abdominal Rebalancing method and Assisted Autogenous Drainage in the care of the Premature Neonate	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-15	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-86tszx	<NULL>	Preterm newborns with corrected gestational age of up to 36 weeks and 6 days; with more than 72 hours of life; without pressure ventilation support; hemodynamically stable; Silverman-Andersen Bulletin (BSA)&gt; 1; weight greater than or equal to 1,100 g and with increasing weight gain.	Preterm newborns with congenital malformations; in parenteral nutrition; score of apgar in the 5th minute &lt;6; with grade III or IV Peri-intraventricular hemorrhage (PIVH).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4mm5xd3	Effects of rest on low back strength in healthy adults and with chronic non-specific low back pain	Recruiting	Intervention	2023-01-17	<NULL>	<NULL>	5829	Effects of the recovery interval on the strength of the trunk extenders in healthy adults and with chronic non-specific low back pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-22	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4mm5xd3	<NULL>	Civilians from the Federal District and surroundings; Healthy people; Diagnosed with chronic non-specific low back pain; Men; Individuals between 18 and 55 years old; Be physically fit and willing to complete training sessions	Classifieds with a red flag (medical emergency); Signs of infection or inflammation in the spine, and in the lower and upper extremities in the last 3 months; Postoperative period of chest and abdomen less than 6 months; Trauma or surgery to the spine; Fibromyalgia; Rheumatological or myopathic diseases; Uncontrolled cardiovascular disease; Neurological disease; People who have undergone physiotherapeutic treatment for the spine or who have performed it during the last 3 months; Persons who are away from work for medical reasons.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-2g8tk6t	Effects of resveratrol on heart health after exercise in menopausal women	Not yet recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9129	Effects of resveratrol supplementation on cardiovascular Recovery and post-exercise muscle function in menopausal women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Fundaçao Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Women aged 40 to 60 years with body index mass of 18.5 to 34.9 kilograms per square meter and low density lipoprotein high or equal to 130 milligrams per deciliter will participate in the study; All participants must be postmenopausal at the start of the intervention; Age at menopause will be categorized as under 45 years early menopause 45 to 49 years relatively early menopause 50 to 51 years reference or 51 years or older relatively late menopause; They must have had no menses in the last year; Able to comply with the study protocols; They must not have any pathologies that could affect their nutritional status; During participation in this clinical trial all women will receive special attention to ensure their well-being comfort and safety; The study was ethically designed to minimize any physical risks associated with the data collection steps	Self-reported use of anticoagulant agents including nonsteroidal anti-inflammatory drugs oral cortisone or other immunosuppressive agents; Presence of neoplasia or immunological disease; Restricted or reduced physical activity due to chronic health conditions; Blood pressure high or equal to 140/90 millimeters of mercury; Kidney or liver disease; Heart disease including cardiovascular events or stroke; Cancer diagnosis in the last five years; Inability to comply with study requirements and procedures; Inability to perform treadmill test due to limitations such as orthopedic problems or moderate to severe aortic stenosis; History of myocardial infarction in the last three months or angina under treatment; Inability to perform handgrip test due to limitations such as pain or deformity	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-9qm7bqr	effects of Rhodiola rosea supplementation on psychoaffective and physiological parameters during resistance training in young and older adults	Recruiting	Intervention	2026-01-22	<NULL>	<NULL>	8789	evaluation of the effects of acute rhodiola rosea supplementation on psychoaffective and physiological parameters associated with resistance training in young and older adults	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-14	Universidade Federal do Rio de Janeiro Campus Macaé	<NULL>	<NULL>	<NULL>	Adults aged between 18 and 45  years old for young adults and above 60 years old for older adults; individuals engaged in resistance training for at least six months prior to the first study visit; with or without a diagnosis of common mental disorders (anxiety and/or depression); of both sexes	Osteoarthritis and rheumatoid arthritis; human immunodeficiency virus (HIV) infection; musculoskeletal disorders that prevent physical exercise; hypertension (systolic blood pressure above 120 mmHg and/or diastolic blood pressure above 80 mmHg); cardiovascular diseases; pregnancy and lactation; use of anticonvulsants; use of central nervous system stimulants, such as methylphenidate (Ritalin®, Concerta®), lisdexamfetamine (Vyvanse®, Juvene®), bupropion hydrochloride (Wellbutrin XL®, Zetron XL®, Bup), lithium carbonate (Carbolithium®); smokers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-3ft2rq	Effects of robotic therapy on the gait of post-stroke individuals	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1927	Effects of robotic therapy on the gait kinematics of chronic hemiparetic individuals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-30	Universidade de São Paulo	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3ft2rq	<NULL>	The subjects who present the last episode of stroke, single, unilateral and ischemic for more than 6 months, without documented changes in motor or sensory impairment, will be included in the study; muscle tone or reflex activity in the 3 months prior to the subject&apos;s participation in the study; the level of spasticity equal to or less than 2 in the Modified Ashworth Scale for lower limbs, allowing individuals to perform the test, 3 to 5 according to the Functional Ambulation Category. The ankle joint should be kept in a neutral position and without deformities. In addition, they must present a minimum score in the Mental State Mini Exam according to the volunteer&apos;s schooling. The Beck Depression Scale inventory will be used to identify individuals with depression. Individuals with values greater than 63 will be excluded. The age range will be between 40 and 70 years.	Subjects with severe cardiovascular diseases, heart failure, arrhythmias or angina pectoris, will be excluded from the study; rheumatic diseases; body mass index greater than 28 kg/m² changing the reliability of the EMG data; other orthopedic or neurological diseases that compromise the collection of data through the isokinetic test and cognitive or communication deficiencies that make it impossible to perform the procedures; painful contractures or deformities in the paretic ankle; shortenings that make it impossible to perform tests or promote pain; show the range of motion less than 10o for dorsiflexion and 20o for plantar flexion according to goniometry; cerebellar ataxia; sensory deficit defined by the loss of proprioception of the first phalangeal metatarsus; hemi- sensorial neglect on neurological examination; various neurological disorders; participation in rehabilitation programs; the presence of pain during the procedures will be considered exclusion criterion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-6pngwz	Effects of rosuvastatin and sevelamer in coronary calcification in chronic kidney disease patients	other	Intervention	2011-07-20	<NULL>	<NULL>	18	Effects of rosuvastatin and sevelamer in coronary calcification in chronic kidney disease patients not on dialysis	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	<NULL>	UNIVERSIDADE FEDERAL DE SAO PAULO	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-6pngwz	<NULL>	All patients were older than 18 years and were followed by a nephrologist for at least 03 months.	Exclusion criteria were the presence of chronic inflammatory diseases, active malignancy, human immunodeficiency virus (HIV), viral hepatitis and chronic steroids intake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-5q5nz4	Effects of running technique modification	Not yet recruiting	Intervention	2015-02-23	<NULL>	<NULL>	400	Effects of Running Technique Modification on lower limb kinematics and muscle activation in runners with and without Patellofemoral Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade Federal de São Carlos/UFSCar	Universidade Federal de São Carlos/UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-5q5nz4	<NULL>	"Rearfoot strikers, familiar with treadmillrunning and run a minimum of 20 km/wk at least 3 months prior to study enrollment
All must have previous anterior or retropatellar pain in at least three of these activities: up/down stairs, squatting, running, kneeling, jumping and after seated for long periods; insidious onset of symptoms unrelated to traumatic incident and persistent for at least three months during the running activity; presence of pain after patellar compression and usual pain in the last week of at least 3 cm on the visual analog scale of 10 cm."	Signs or symptoms of: meniscal or intra-articular pathology; previous knee joint ligament injuries; ligamentous laxity; sign of patellar apprehension; Osgood-Schlatter or Sinding-Larsen-Johansson syndrome; lumbar spine,  hip or ankle pain; prior patellar dislocation; evidence of knee joint effusion; lower limb surgery; cardiovascular or neurological  diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-5j4wkxk	Effects of S-PRG Nanoparticles Dispersion on Gum Tissues	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8398	Evaluation of the effects of S-PRG Nanoparticle dispersion on periodontal tissues: in vitro analysis of biological interactions and clinical trial in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-10	Instituto de Ciência e Tecnologia - São José dos Campos - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - São José dos Campos - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5j4wkxk	<NULL>	Individuals with gingivitis presenting a gingival bleeding index equal to or greater than 10%; probing depth equal to or less than 3 mm; aged 18 years or older; in good general health; and willing to participate in the study by signing the informed consent form	Individuals with periodontitis; smokers; pregnant or breastfeeding women; individuals who have used mouthwashes within the past 6 months; those under chronic use of medications that affect periodontal response, such as antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressants, or sodium channel blockers within the past 6 months; individuals with systemic conditions such as diabetes, cardiovascular disease, cancer, obesity, rheumatoid arthritis, metabolic syndromes, respiratory diseases, or those requiring antibiotic prophylaxis; and individuals wearing orthodontic appliances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-9gpxkv3	Effects of same day discharge on safety, quality of life and economical impact and after Cardiac Catheterization	Recruiting	Intervention	2026-02-18	<NULL>	<NULL>	8882	Same day discharge versus overnight observation after Percutaneous Coronary Intervention: economical, safety and quality of life impact	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-01	Associação Paranaense de Cultura	<NULL>	<NULL>	<NULL>	Patients between 18-75 years who have favorable criteria post-intervention, including a Thrombolysis In Myocardial Infarction (TIMI) of 3 in the blood vessel. Absence of occlusion on relevant lateral branches with diameter of ≥ 2 mm. Absence of coronary dissections	ST-segment elevation myocardial infarction (STEMI). Cardiogenic shock. Total obstruction of the targeted blood vessel. Need for left coronary branch or emergency intervention due to persistent chest pain. Clinical instability associated with the reduction of coronary blood flow (TIMI&lt;3). Major bleeding (BARC&gt;1). Prohibition of radial artery access. Need for prolonged anticoagulant therapy. Persistent chest pain. Alterations on the electrocardiogram suggestive of ischemia on the observation period (6 hours after the procedure). Pregnancy. Active malignancies. Simultaneous participation on other clinical trials. Absence of adequate family support	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-75h3nz	Effects of scapula exercises in patients with Fracture of the distal radius	Data analysis completed	Intervention	2018-02-06	<NULL>	<NULL>	2514	Effectiveness of adding scapular control exercises to kinetic treatment in patients with distal radius fracture: Randomized simple-blind clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidad de las Americas	CDT Hospital San Borja de Arriaran	https://ensaiosclinicos.gov.br/rg/RBR-75h3nz	<NULL>	subjects over 60 years of age derived from the Adult Traumatology Service of the San Borja Arriarán Clinical Hospital, with a medical diagnosis of multifrectional extraarticular type FRD according to the AO classification, treated conservatively with closed reduction plus immobilization with plaster. Subjects that accept and sign informed consent.	Subjects presenting some immediate complication after removal of immobilization , painful regional complex type I, carpal tunnel syndrome, etc. subjects presenting a shoulder pathology diagnosed at least 1 year before the occurrence of the DRF, subacromial pinching syndrome, partial or total rupture of the rotator cuff, glenohumeral instability, adhesive capsulitis, etc.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-46zk89	Effects of self-care rests on knowledge, self-care and metabolic control in adult men with diabetes mellitus	Recruiting	Intervention	2016-09-05	<NULL>	<NULL>	979	Effectiveness of self-care rests on knowledge, self-care and cardiometabolic control of adult men with Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-19	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-46zk89	<NULL>	"Having medical diagnosis of DM2.
Being male.
Age between 40 and 70 years.
Is domiciled in the city of Maringa in the FHS coverage area.
Being part of the ESF families register.
Being able to answer the questions of data collection instruments.
Relate visual ability, hearing and locomotor to perform self-care.
Have telephone contact (mobile or fixed) for monitoring the program."	"Present lesions in target organs (brain, heart, kidneys, eyes) or comorbidities/complications resulting from diabetes, recorded in medical records, such as chronic renal failure.
Have psychological or other disorders, registered in the medical records, and that compromise the understanding of the study, who do not agree or do not have availability to participate in the intervention.
Moving to another location that does not have coverage of the ESF, or even to another city."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-684gwrv	Effects of Self-selected and Moderate-intensity Exercise on Anxiety in young people exposed to unpleasant images before or after exercise	Recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6246	Acute effects of Self-selected Intensity Aerobic Exercise and Moderate Intensity Aerobic Exercise on state-anxiety levels in young people exposed to unpleasant stimuli before or after exercise	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-684gwrv	<NULL>	Age between 18 and 40 years old.	Being on your period (for people with a uterus); irregular menstrual cycle (for people with a uterus); have any contraindication on physical activity performance, verified through the Physical Activity Readiness Questionnaire; any type of cardiac, endocrine, orthopedic and metabolic dysfunction; and, to be literate, as there will be a need for the participant to respond to instruments, such as questionnaires, scales and inventories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-2k6xxs7	Effects of Senior Dance® on the Elderly	Recruitment completed	Intervention	2023-08-18	<NULL>	<NULL>	6590	Effects of Senior Dance® in elderly people with and without dementia: controlled clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-2k6xxs7	<NULL>	Elderly of both sexes; aged 60 to 85 years; wheelchair users or not; elderly with cognitive decline according to the Mini Mental State Examination (MMSE) assessment for group G1 belonging to long-stay institutions; elderly without cognitive impairment according to the Mini Mental State Examination (MMSE), non-institutionalized for group G2	Bedridden or seriously ill elderly; seniors with medical restrictions to exercise; elderly with recent fractures and/or in the process of immobilization; elderly with grade 2 and 3 dementia by CDR; seniors with less than 3 years of schooling; elderly unable to respond verbally to the scales/questionnaires; elderly with a previous diagnosis of psychiatric disorders of non-neurodegenerative characteristics; refusal to sign the Free and Informed Consent Term and/or Free and Informed Assent Term; not attending 75% of classes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-657wbq	Effects of sensory training on the sensory and motor performance of children and adolescents with Cerebral Palsy	Recruitment completed	Intervention	2019-05-06	<NULL>	<NULL>	4463	Effects of a sensory training protocol on sensorimotor performance in children and adolescents with Cerebral Palsy:  an exploratory randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-14	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-657wbq	<NULL>	Participants with a diagnosis of unilateral or bilateral cerebral palsy; aged between 5 and 20 years; level of the Gross Motor Function Classification System (GMFCS) between I and III; being able to understand and execute simple commands.	sensory deficits of peripheral origin; neurological, musculoskeletal or cardiorespiratory conditions that may interfere with their ability to perform the proposed activities; be performing any type of intensive physiotherapeutic intervention; orthopedic surgery in the last year; application of botulinum toxin in the four months prior to the study; performed a selective dorsal rhizotomy surgery.              The participation of those who miss at least one training session will be discontinued or they will no longer meet any of the criteria mentioned above during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-2c6ymn	Effects of shiatsu-associated physical therapy on pain and fatigue in patients with Multiple Sclerosis	Recruiting	Intervention	2019-09-19	<NULL>	<NULL>	2974	POSSIBLE SHIATSU EFFECTS ON PAIN AND FAILURE IN PEOPLE WITH MULTIPLE SCLEROSIS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-06	Centro Universitário Filadélfia	Centro Universitário Filadélfia	https://ensaiosclinicos.gov.br/rg/RBR-2c6ymn	<NULL>	Volunteers with diagnosis of multiple sclerosis; of both sexes; older than 18 years; with staging of 0 to 6; were not classified during the 3-month period prior to the start of the study.	Volunteers with neurological diagnosis besides multiple sclerosis; unable to understand or perform the tests proposed in the study; the physical or psychological impossibility of individuals; being hospitalized at the time of data collection or outbreak at the time of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-5nqr3b6	Effects of short exercise sessions throughout the day on physical performance and the cardiovascular system of physically active university students	Recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8742	Effects of Exercise snacks on biomotor capacities and the cardiovascular system in physically active university students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-08	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Adults aged between 18 and 30 years; both sexes; physically active, classified as active according to the short version of the International Physical Activity Questionnaire (IPAQ); absence of cardiovascular diseases; absence of metabolic diseases; absence of musculoskeletal and/or osteoarticular conditions that may limit the performance of the proposed exercises; voluntary agreement to participate in the study through written informed consent.	Participants who do not complete all pre- and post-intervention assessments; attendance lower than 75% of the scheduled training sessions.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-53ds9z	Effects of short-term memory therapy using spoken stimuli and reading stories in children who do not understand what they read	Data analysis completed	Intervention	2018-09-19	<NULL>	<NULL>	2214	Effects of the intervention in phonological memory and shared reading of history in school children with difficulties in reading comprehension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulos	FAculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-53ds9z	<NULL>	age between 8 and 10 years and 11 months; attending the fourth or fifth year of elementary school; not having speech therapy because of difficulties in reading, writing and speaking; have no syndromes or hearing or visual loss.	percentage greater than 25% of absences during the 15 days of therapy (intervention meetings); not carry out the activities during the meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-4qhkf4	Effects of Sildenafil on exercise breath in subjects with mild to moderate COPD	Recruiting	Intervention	2018-11-30	<NULL>	<NULL>	3322	Effect of Sildenafil on mechanical ventilation, mechanical ventilation and dyspnea during exercise with mild to moderate COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Federal do Rio Grande do Sul	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4qhkf4	<NULL>	The sample eligible for the study will consist of volunteers with a previous diagnosis of COPD; both genders; GOLD I or II; clinical stability; no signs of exacerbation in the eight weeks prior to the study; capable of performing bicycle exercise testing; sign the Informed Consent Form.	Individuals with associated diseases that may compromise exercise performance; use of oxygen therapy; SpO2 less than 85% at rest in ambient air; receiving chronic or eventual nitrate therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-9t6rd7	Effects of sildenafil on the pulmonary microvascular disease of symptomatic smoker	Not yet recruiting	Intervention	2020-01-22	<NULL>	<NULL>	3390	Effects of sildenafil on exercise responses in symptomatic individuals with evidence of tobacco-associated pulmonary microvascular disease: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	Universidade Federal de Mato Grosso do Sul	Hospital Universitário de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9t6rd7	<NULL>	Symptomatic vascular phenotype; Individuals of both sexes; Age between 35 and 80 years; History of smoking for more than 10 years; Sinus rhythm; Preserved left ventricular ejection fraction (higher than 50%); The evaluated patients should be able to perform spirometry, carbon monoxide diffusion test and cardiopulmonary exercise test.	"Carrier of diabetes mellitus, bronchial asthma, previous myocardial infarction, heart failure, complex ventricular arrhythmias; Chronic atrial fibrillation; Body mass index lower than 18.5 or higher than 35 kg per m²; Anemia with hemoglobin lower than 11 g% in women and lower than 12 g% in men; Chronic hypoxemia of undetermined cause; neuromuscular, orthopedic or psychological limitation;
Contraindication to the use of sildenafil citrate or previous use of it thereof."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-3cxz39	Effects of simulation on the performance of health information systems	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2702	"Dissemination of technological innovation: Information System of the National
Immunization"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de São João del Rei	Universidade Federal de São João del Rei	https://ensaiosclinicos.gov.br/rg/RBR-3cxz39	<NULL>	"Nursing professionals working in the vaccination room with the Information System of the National Immunization Program implemented; nurses working in the vaccination ward for at least six months should have a knowledge of the work in the vaccine room and that express interest in
participate in the study."	Those professionals who do not carry out activities in the vaccine room and who do not want to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-6ptj3fp	Effects of simultaneous exercise in the elderly	Not yet recruiting	Intervention	2021-01-12	<NULL>	<NULL>	4470	Effects of dual task in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Faculdade Maurício de Nassau	Faculdade Maurício de Nassau	https://ensaiosclinicos.gov.br/rg/RBR-6ptj3fp	<NULL>	Volunteers of both sexes; aged 60 or over; non-obese (BMI bigger then30 Kg / cm2); sedentary or irregularly active according to the International Physical Questionnaire (PARDIDI et al. 1997); with independent gait and without physical, visual or auditory deficits that make it impossible to assess and / or apply the protocols; without cognitive deficit, indicated by a score equal to or greater than 22 points in the Leganés Cognitive Test (ZUNZUNEGUI et al., 2000).	Volunteers who have a phobia of water; acute infections; with the presence of phlogistic signs; fever; deep vein thrombosis; unstable cardiovascular diseases; urinary or fecal incontinence; epilepsy; tympanic perforations; in addition to epithelial disorders such as wounds; polite; dermatitis and / or fungi that can contaminate the pool and / or therapist.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-5gjrzz	Effects of single and double task in elderly people with Toxoplasmosis	Recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3784	Analysis of the effects of single and dual task in elderly people infected with toxoplasma gondii:  A randomized controlled trial double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Faculdade de ciências da saúde do trairi-UFRN	Faculdade de ciências da saúde do trairi-UFRN	https://ensaiosclinicos.gov.br/rg/RBR-5gjrzz	<NULL>	Volunteer individuals aged at least 60; of both sexes; and have good cognitive status to understand simple commands	Individuals with severe orthopedic; neurological; rheumatological diseases and who have undergone any physical therapy treatment in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-32dp35h	Effects of sitting time on blood circulation, blood pressure, and muscle activity in adults	Recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7658	Cardiometabolic and cardiovascular responses, strength, and muscle electrical activity during multistage prolonged sitting in sdults	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-08-02	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-32dp35h	<NULL>	Healthy young adults aged between 18 and 50 years; Absence of previous diagnosis of chronic diseases, such as diabetes mellitus (type 1 or type 2), hypertension, cardiovascular diseases, neuromuscular or metabolic disorders; No use of continuous medications, including antihypertensives, antidiabetics, anti-inflammatory drugs, beta-blockers, or any other medication that may influence metabolism, the cardiovascular system, or muscle function; No use of supplements or ergogenic substances (e.g., creatine, caffeine, beta-alanine) in the 30 days prior to participation in the study; Absence of musculoskeletal injuries, chronic pain, orthopedic conditions, or any other physical limitation that prevents prolonged sitting (minimum of 3 hours); Consent to follow all research protocol guidelines, with availability to participate in the experimental session and complete all study stages	Interruption or non-completion of any phase of the study, including initial screening, anthropometric assessments, reference tests, or the experimental session; Development of any acute condition (e.g., fever, infection, acute injury) or diagnosis of a chronic condition during the screening and data collection period that may interfere with the study outcomes; Intake of alcohol, caffeine, medications, or ergogenic supplements within the 24 hours prior to the experimental session; Participants with elevated levels of sedentary behavior (e.g., more than 12 hours/day sitting) or engaging in vigorous physical activity (&gt;300 minutes/week) that may influence the study results; Exposure to environmental conditions that may alter thermoregulation or cardiovascular function (e.g., sunburn, hot baths close to the experimental session)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-29vkvt	Effects of skin and grape seed syrup on obese subjects	Recruitment completed	Intervention	2018-10-26	<NULL>	<NULL>	2302	Effects of the supplementation of skin and seed extract of the São Francisco Valley grapes on cardiovascular, glycemic, lipidic, inflammatory responses and quality of life of adolescents and adults with excess weight	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-08	Universidade Federal do Vale do São Francisco (UNIVASF)	Universidade Federal do Vale do São Francisco (UNIVASF)	https://ensaiosclinicos.gov.br/rg/RBR-29vkvt	<NULL>	Body mass index above 30 kg / m2; be sedentary.	Have diabetes mellitus; have systemic arterial hypertension; be using any method of weight loss either through lifestyle modifications, pharmacological treatment or any antioxidant and anti-inflammatory supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-27tzbmm	Effects of Slow Breathing on cardiovascular and hormonal changes during stress	Recruiting	Intervention	2024-05-28	<NULL>	<NULL>	7035	Effects of Slow Breathing on perception and cardiovascular and endocrine reactivity to stress	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-15	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-27tzbmm	<NULL>	Young adults (18 to 40 years old); of both sexes; eupneic (respiratory rate &gt; 10 breaths/minute); without diagnosis of mental disorders, cardiorespiratory and metabolic diseases, or cognitive deficit	Raynaud&apos;s syndrome or hypersensitivity to cold; using drugs that may influence the cardiovascular response; who regularly perform breathing or meditative practices; athletes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-78wjpqz	Effects of sound stimulation and Exercises on the perceptions of individuals with symptoms of Depression	Recruiting	Intervention	2023-04-20	<NULL>	<NULL>	6028	Effects of stimulation by Binaural audio and Self-selected exercises on interoceptive and perceptual responses of individuals with symptoms of Depression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-78wjpqz	<NULL>	Adults; both sexes; symptoms of depression	Attendance less than 70 %	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-88vgp6	Effects of soy beans isoflavone in the vagina and the uterum in the post menopausal womens	recruitment completed	Intervention	2012-01-04	<NULL>	<NULL>	56	Effects of Glycine max (L.) Merr in the vaginal epitelium and the endometrium in post menopausal women	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-01-01	FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO	FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO	https://ensaiosclinicos.gov.br/rg/RBR-88vgp6	<NULL>	"Women with age 45-68 years old
Vaginal atrophy simptons
Menopause &gt;12 months
With out hot flushes
No contraindications for hormonal terapy"	"Hot flushes symptons
Breast neoplasy and endomtrium
With Hormonal teraphy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-994xfs	Effects of specific therapies on the masticatory system and on sleep variables  in cerebral palsy patients.	recruiting	Intervention	2011-11-24	<NULL>	<NULL>	36	Randomized, five arm clinical trial to evaluate the effects of neuromuscular electrical stimulation, lasertherapy and ledtherapy on the masticatory system and the impact on sleep variables  in cerebral palsy patients.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-07	UNESP-Universidade EStadual Paulista Juluo de Mesquita Filho/ Faculdade de Odontologia de Sâo José dos Campos	UNINOVE -Universidade Nove de Julho- São Paulo - SP	https://ensaiosclinicos.gov.br/rg/RBR-994xfs	<NULL>	Subjects from both gender, between 7-15 years old with cerebral palsy; present cognitive system partly preserved; sign the consent term.	Have used botulim toxin before 6 month prior the study;have underwent ortodontic treatment prior the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-9r5j8g	Effects of specificity of Inspiratory Muscle Training in Individuals with Spinal Cord Injury	Recruitment completed	Intervention	2019-04-01	<NULL>	<NULL>	6659	Effects of specificity of Inspiratory Muscle Training on functional capacity, respiratory function, pulmonary endurance and quality of life of patients with complete motor Spinal Cord Injury	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9r5j8g	<NULL>	Patients diagnosed with SLE (AIS A or B) according to the American Spinal Injury Association, classified with tetraplegia; At least 6 months of injury; Being in treatment in the hospitalization sector for rehabilitation in the CRER; Both the sexes; Age greater than 18 years; 10% reduction in predicted vital capacity (FVC); Signature of the Informed Consent Term (TCLE).	Patients with non-LME associated pulmonary and / or cardiac diseases; Patients with previous neurological disease; Pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-4mt6yr	Effects of speech therapy on chewing of individuals who underwent surgery to correct an imbalance in facial pattern	Recruitment completed	Intervention	2016-05-10	<NULL>	<NULL>	843	Effects of  miofunctional therapy on masticatory function of patients undergoing orthognathic surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-20	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-4mt6yr	<NULL>	Experimental group: age between 18 and 45 years; regardless of gender and present Class II malocclusion or Class III malocclusion. Control group: young adults; good health both general and oral; relationship between dental arches with horizontal and vertical overlap between 1 and 3 mm; natural dental elements at least until the second molar; nasal breathing.	Neurological psychiatric and intellectual deficits; partial or total edentulous patients; presence of cleft lip and palate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-9252kwm	Effects of Spinal Cord Electrostimulation on Chronic Pain	Recruiting	Intervention	2024-05-06	<NULL>	<NULL>	6987	Effects of Transcutaneous Medullary Direct Current Stimulation on Chronic Pain: randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-9252kwm	<NULL>	Adults between 18 and 80 years old; with hearing acuity; no history of neuropsychiatric disorders or self-reported use of psychoactive substances; that are sufferers of chronic pain (for more than 3 months)	Individuals with epilepsy, taking anticonvulsant medication, and/or experiencing sleep deprivation; participants with metallic materials implanted in or near the head (e.g., cochlear implant, implanted electrodes/stimulators, aneurysm clips or coils, firearm projectile fragments, jewelry, and hair clips); participants with pacemakers or cardiac wires (Stents), or any other active device where interaction with an electric field may interfere with its functioning; participants with eczema on the head or trunk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-595kgk7	Effects of Spirulina Platensis supplementation on inflammation and body composition in adults following surgical treatment for obesity	Recruitment completed	Intervention	2023-08-29	<NULL>	<NULL>	6398	Effects of Spirulina Platensis Supplementation on inflammatory markers, mitochondrial oxidative stress and body composition in adults after bariatric surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-05	Universidade Federal de Mato Grosso - UFMT	Centro Universitário de Várzea Grande - UNIVAG	https://ensaiosclinicos.gov.br/rg/RBR-595kgk7	<NULL>	adult individuals; of both sexes; aged between 18 and 59 years; with a Body Mass Index (BMI) greater than or equal to 40 or greater than or equal to 35 with morbidities associated with obesity such as type 2 diabetes mellitus, hypertension, dyslipidemia; who will undergo gastric bypass bariatric surgery treatment, and who will be regularly monitored by the research team	individuals who have a medical diagnosis of consumptive diseases such as stage 3, 4 or 5 chronic kidney disease; acute or chronic pancreatitis; severe acute infections; individuals who report the use of narcotic drugs and who are using vitamin or mineral supplements during the study period; or who have special physical conditions that interfere directly, causing errors in interpretation of the parameters investigated	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-6yrddt	Effects of sports and functional training in quality of life of adults with visual impairment	Recruitment completed	Intervention	2019-10-17	<NULL>	<NULL>	3103	Effect of sport exercises and functional training in levels of physical activity, physical fitness, pleasure and quality of life of adults with visual impairment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Escola Superior de Educação Física da Universidade Federal de Pelotas	Escola Superior de Educação Física da Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-6yrddt	<NULL>	The inclusion criteria for the study were to be in the age group of 18 years to 59 years and to have visual impairment (vision worse than 20/60) clinically proven.	People with other associated impairments (physical, hearing or intellectual) were not eligible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-10bfs3gm	Effects of Sports Training associated with Nutritional Intervention on adolescent health	Not yet recruiting	Intervention	2025-03-11	<NULL>	<NULL>	7832	Effects of Sports Training associated with Nutritional Counseling on cardiovascular risk factors in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-15	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10bfs3gm	<NULL>	Adolescents of both sexes; aged between 11 and 14; residing in Porto Alegre - RS and the metropolitan region; available to participate on determined days and times	Adolescents with any pathology or injury that limits the total or partial execution of the training protocol; using medications that influence the results (for example: statins, hypoglycemic agents or beta-blockers); pregnancy; who have been participating in some physical activity/exercise or following some nutritional counseling program for at least six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-6tg4myr	Effects of Square-Stepping Exercise in cognition, functioning and prevention of falls in elderly people with Parkinson&apos;s Disease	Recruiting	Intervention	2025-05-20	<NULL>	<NULL>	8011	Effects of Square-Stepping Exercise in cognitive function, functioning and prevention of falls in elderly people with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Federal de Ciências da Saúde de Porto Alegre	Secretaria Municipal de Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6tg4myr	<NULL>	Be 60 years of age or older; both sexes; live in Porto Alegre; be available to participate in the program on the established days and times; having been diagnosed with Parkinson&apos;s disease, stages I, II or III, according to the Hoehn Yahr scale; have signed informed consent for the study	Have physical limitations that make it impossible to perform the proposed exercises; have any clinical condition that contraindicates physical exercise; suffer from severe cognitive impairment determined by a score less than12 on the Mini-Mental State Examination; disabling pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-22k3fm7	Effects of Stimulation of the Auricular Branch of the Vagus Nerve on Cardiovascular parameters in people recovered from Covid-19	Recruitment completed	Intervention	2024-09-11	<NULL>	<NULL>	7330	Effects of Stimulation of the Auricular Branch of the Vagus Nerve on Cardiovascular parameters in people recovered from Covid-19	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-22k3fm7	<NULL>	Adult males and females; age between 18 and 60 years; recovered from Covid-19, with supporting documentation, a minimum of four weeks and a maximum of one year and who remain with at least one of the characteristics of the subacute or chronic phase of the disease; having received assistance in the health network of Santa Catarina; being able to walk independently; understand Brazilian Portuguese well enough to complete questionnaires and tests	Individuals with pre-existing cardiovascular diseases; smokers; suspected or confirmed pregnancy; cognitive alterations, injuries to the pinna or its absence; without supporting documentation for a positive Covid-19 test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-9b5dh7	Effects of Stimulation Transcranial Direct Current by Associated Gait Training and Mobility Functionality About Children with Cerebral Palsy	Recruiting	Intervention	2013-04-18	<NULL>	<NULL>	179	Effects of Stimulation Transcranial Direct Current by Associated Gait Training and Mobility Functionality About Children with Cerebral Palsy: Clinical Trial Randomized Controlled, Double Blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Universidade Node de Julho	Centro de Neurocirurgia Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-9b5dh7	<NULL>	Children with cerebral palsy. Age between 4 and 12 years. Absence of cognitive or visual impairment that could compromise the performance of the tasks. Levels I, II and III of the Gross Motor Functional. Classification System (GMFCS). Functional ambulation for at least 12 months.	Orthopedic surgical procedures or neuromuscular block in the 12 months prior to the training sessions. Presence of orthopedic deformities with surgical indications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-2kch38	Effects of Stomach Reduction Surgery on oral health	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	1353	Repercussions of Bariatric Surgery on oral health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-20	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-2kch38	<NULL>	Obese volunteers of both genders; aged between 16 and 60 years; with indication for stomach reduction surgery; who underwent bariatric surgery in the year 2015 and 2016.	Edentulous individuals; with physical limitations; with mental limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-535smn	Effects of Strength and Aerobic Training on Physical Performance in Patients with Chronic Obstructive Pulmonary Disease who Use Oxygen at Home	Recruitment completed	Intervention	2018-07-24	<NULL>	<NULL>	2051	Effectiveness of Resistance and Aerobic Training on functional performance in patients with COPD users of home oxygen therapy: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Parana	https://ensaiosclinicos.gov.br/rg/RBR-535smn	<NULL>	We included patients with clinical and functional diagnosis of COPD according to the criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) (RABE et al, 2007), both sexes over 50 years of age, clinically stable (outside the period of exacerbation regardless of disease staging, and who used home-based oxygen therapy regardless of the time (hours / day) of use and who were not included in any rehabilitation program or physical training in the last year.	Patients with other lung diseases (asthma, pulmonary fibrosis, pneumonia) were excluded; presence of other non-pulmonary diseases considered to be incapacitating, severe or difficult to control (eg heart disease or the sequelae of acute or chronic neurological diseases), which could disrupt the application of tests; those with cognitive status compromised according to the Mini Mental State Examination (MMSE) (&lt;13 for illiterates; &lt;18 for individuals with 1 to 7 years of schooling and &lt;26 for 8 years or more of schooling).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-53rgg2	Effects of strength exercises for anterior knee pain.	Recruiting	Intervention	2019-01-10	<NULL>	<NULL>	2434	Effectiveness of a resistance exercise program and neuromuscular training for patients with Patellofemoral Pain Syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-10	Instituto de Pesquisa e Ensino do Hospital HOME	Centro Universitário de Brasília - UniCEUB	https://ensaiosclinicos.gov.br/rg/RBR-53rgg2	<NULL>	Will be submitted in the study women with anterior pain in the knee and around the patellofemoral joint; Pain reported on at least two of the following criteria: when going up and down stairs, crouch, jump, after long sitting periods, cracking or crackling, palpation pain, report pain lasting at least two months, report a maximum of 86 points on the scale anterior pain in the knee (maximum = 100 points) and pain at least three in the numerical scale of pain.	Women with any possible degenerative changes of the knee and hip, age between 18 and 45 years, subjects with previous knee and hip surgery, history of patellar dislocation, clinical evidence of knee instability, meniscal or intraarticular lesions, evidence of edema, osgood-schlatter or sinding-larsen-johanssen, patellar tendinopathy, muscular lesions, low back or sacroiliac pain and limb length difference greater than 1cm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-22rnjh	Effects of strength exercises on postoperative knee rehabilitation	Recruiting	Intervention	2018-04-10	<NULL>	<NULL>	1700	Effectiveness of unilateral resistance training in the postoperative rehabilitation of contralateral ACL	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-31	Universidade Federal de São Paulo / Escola Paulista de Medicina	Instituto de Pesquisa e Ensino do Hospital HOME	https://ensaiosclinicos.gov.br/rg/RBR-22rnjh	<NULL>	Will be included in the study patients of both genders, with different occupations, who practice physical activity at a recreational level, suffered the traumatic injury of the ACL and were submitted to primary reconstruction surgery using contralateral LP grafting (technique in which the graft of the limb opposite the injured). In order for the age group with the highest prevalence of lesions in the ACL (LARSON, 1994) to be respected, in addition to the exclusion of minors, everyone must be aged between 15 and 45 years.	Patients with a history of lesions and / or surgery in the knees prior to or after the injury that generated the clinical picture studied, and those who did not complete all stages of the study, will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-5w2sqt	Effects of strength exercises with elastic bands and tubes on the difficulty of movements, quality of life, sleep, memory, depressive symptoms, balance and risk of falls of patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2020-03-25	<NULL>	<NULL>	4399	Evaluation of the effects of a power strength training program with elastic bands and tubes on cognition, functionality, quality of life, balance, physical fitness, muscle quality, balance, sleep and the risk of falls of Parkinson&apos;s disease patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-13	Faculdade de Medicina da  Universidade Federal do Ceará	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5w2sqt	<NULL>	Diagnosis of Parkinson’s disease according to the UK PD Brain Bank Diagnostic Criteria; Stages of 1 to 3 according to the modified Hoehn &amp; Yarh  scale; Stable antiparkinsonian medication regime for at least 4 weeks before the intervention; Literate; Independent in basic daily living activities according to SE higher or equal to 80%; Age of 40 years or more; Be a resident of Fortaleza.	"BMI greater than 40 and less than 20; Diagnosis of Chron&apos;s Disease and Ulcerative Colitis; Diagnosis of Multiple Sclerosis, ADEM, Parkinsonism plus, cerebrovascular disease with motor sequelae, Guilliam-Barre; Dementia syndrome of any etiology according to MSD-V; Schizophrenia with hospitalization or psychotic episode or suicidal ideation in the last 6 months; Bipolar affective disorder with hospitalization or episode of mania or episode of hypomania or episode of depression in the last 6 months; Depression with hospitalization or suicidal ideation or psychotic episode in the last 6 months; Myocardial infarction with or without ST elevation in the last 12 months; Myocardial revascularization surgery or percutaneous anglioplasty in the last 12 months; Uncontrolled arrhythmia; Severe or oxygen dependent COPD; Cardiac insufficiency with reduced functional class III or IV; Resting Blood Pressure greater than or equal to 160 x 100 mmHg;  Implantable cardioversion defibrillator (ICD);  Severe chronic kidney disease (Creatinine clearance less than 30ml/min); Proliferative retinopathy secondary to diabetes; Peripheral neuropathy with motor impairment;
Moderate to severe hearing impairment (inability to maintain a dialogue or need for lip reading); Moderate to severe visual impairment (minimum visual acuity 20/70 - Snellen); Cancer in activity or in treatment; History of conventional surgery or DBS for Parkinson&apos;s disease; Alcohol consumption greater than 14 drinks per week; Live with people who participate in the same study; Thromboembolism without anticoagulation regimen; Significant weight loss (10% of usual weight) in the last 6 months; Lack of family support to participate in the study; Bariatric surgery history; Exercise at moderate intensity for at least 3 x week; Glycated hemoglobin higher than 12."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-8md6c9	Effects of strength training on the shortest range of disturbances in environments of corporal achievement, strength, functional capacity, blood pressure and skin temperature in women of advanced age	Recruitment completed	Intervention	2018-12-11	<NULL>	<NULL>	2378	Effects of strength training with blood flow restriction in different environments on morphological, neuromuscular, hemodynamic, functional and inflammatory variables in middle-aged and elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Instituto Federal de Educação Ciência e Tecnologia do Ceará	Instituto Federal de Educação Ciência e Tecnologia do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8md6c9	<NULL>	Inclusion criteria: Respond negatively to all items in the Physical Activity Readiness Questionnaire / PAR-Q; not having practiced strength training for six months; present medical certificate for training participation; absence of history of cardiovascular diseases, not having or having had any type of musculoskeletal injury in the lower limbs in the last six months.	The exclusion criterion consists of: not having 75% of frequency in the training program (FERREIRA et al., 2005)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-3bvgx7	Effects of Strength Training with Reduced Blood Flow in Patients with Wear at the Knee Joint	Recruitment completed	Intervention	2019-10-08	<NULL>	<NULL>	4738	Effects of Blood Flow Restricted strength training on muscle pain, strength, and hypertrophy and quality of life in patients with knee Osteoarthritis: A randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-15	universidade comunitária da região de chapecó	universidade comunitária da região de chapecó	https://ensaiosclinicos.gov.br/rg/RBR-3bvgx7	<NULL>	Men and women with a diagnosis of osteoarthritis of the knee will be included in the present study. Classified according to criteria established by the American College of Rheumatology. Within the age range of 60 to 70 years and without clinical restriction to perform the exercise protocol.	Patients submitted to a recent surgical procedure will be excluded; last three months. As well as those who have diagnosed vascular problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-8vvpztm	Effects of strength training with Vascular Occlusion associated with Electrical Stimulation	Not yet recruiting	Intervention	2023-03-24	<NULL>	<NULL>	5958	Effects of strength training with Blood Flow Restriction associated with Neuromuscular Electrostimulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Estadual Paulista Júlio de Mesquita Filho - Instituto de Biociências	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8vvpztm	<NULL>	Will be included in the study participants of both sexes; aged between 18 and 45 years; physically active	Body Mass Index (BMI) above 30; alterations in sensibilities and mental disturbances that may alter the results or be harmful to the subject; risk factors for thromboembolism; who have a family history of deep vein thrombosis or pulmonary embolism; who have hypertension (blood pressure at rest &gt; 140/90 mmHg)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-738h37	Effects of Strength Training with Vascular Occlusion on the physical performance and pulmonary function of people with COPD	Data analysis completed	Intervention	2018-05-01	<NULL>	<NULL>	2367	Chronic effects of Strength Training with Blood Flow Restriction on the physical performance and pulmonary function of people with COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-738h37	<NULL>	Diagnostic of moderate or severe COPD (post-bronchodilatatior VEF1 between 30 and 60% of the predicted value); aging 50 years or more; clinicaly stable for at least a month before treatment (infections or acute exarcebations); non-smokers or ex-smokers for at least a year; without cardiovascular or orthopedic diseases that make impossible performing the exercises; being under medical treatment; have bachial-ankle index between 0.9 and 1.3, indicating that there is no risk of peripherical artery disease.	Will be excluded from the sample those who: exarcebate the disease during the treatment protocol; stop taking medication; present oxygen saturation smaller then 85% during exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5bqfyt	Effects of strength-training on Breast Cancer Survivors	Recruitment completed	Intervention	2018-03-08	<NULL>	<NULL>	2090	Effects of Resistance Training on quality of life, mood disorders, spinal curvature, fatigue indicators and muscle performance in Breast Cancer Survivors	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-09	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5bqfyt	<NULL>	Staging history I to III confirmed; age between 40 and 65 years; being in menopause; not being involved in any regular exercise program in the last 6 months; have completed all cancer-related therapies, including, surgery, chemotherapy and / or radiation; be at least 6 months after treatment; hormone therapy (eg tamoxifen or aromatase inhibitor).	Osteomioarticular limitations that could compromise the exercise protocol; uncontrolled chronic disease that could represent a risk to the health of the volunteer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-5hcts9p	Effects of stretching via telehealth in community-dwelling older adults	Recruiting	Intervention	2023-02-03	<NULL>	<NULL>	5863	Effects of Active-Fascial Stretching via telehealth in community-dwelling Older Adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-30	Universidade São Judas Tadeu	Universidade São Judas Tadeu	https://ensaiosclinicos.gov.br/rg/RBR-5hcts9p	<NULL>	Independent seniors; absence of severe impairment of systems such as impairment of the auditory, vestibular, proprioceptive, neurological or musculoskeletal systems; absence of joint range of motion limitation; not using medications that could alter postural balance; not presenting cognitive impairment; familiar with the use of the internet and applications; have internet; having a cell phone or tablet or computer to watch and practice classes; mandatory presence of a family member to accompany you during class; be a resident of the city of São Paulo or surrounding cities.	dependent elderly; severe system impairment such as auditory, vestibular, proprioceptive, neurological, or musculoskeletal impairment; limitation of range of joint movement; making use of medications that may alter postural balance; present cognitive deficit; not being familiar with the use of the internet and applications; not having internet; not having a cell phone or tablet or computer to watch and practice classes; not having a companion during class; not be a resident of the city of São Paulo or surrounding cities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-1072m6nv	Effects of subcutaneous ketamine on depression	Not yet recruiting	Observational	2021-05-17	<NULL>	<NULL>	4660	Effects of subcutaneous ketamine on treatment resistant depression	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-07-15	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-1072m6nv	<NULL>	Patients in current severe depressive episode, occurring for at least 4 weeks, and who have already used at least two antidepressant drugs, in an appropriate dose and duration; age between 18 and 45 years old.	uncontrolled hypertension; congestive heart failure or other evidence of impaired cardiac status; COPD; severe obesity; increased intracranial or cerebrospinal pressure; pregnancy; hyperthyroidism; adverse response to ketamine; present or past psychotic symptoms; dissociative identity disorder; autism spectrum disorder; prodromal symptoms of schizophrenia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:31
RBR-6wvpjq	Effects of substances used after dental bleaching	Data analysis completed	Intervention	2015-08-07	<NULL>	<NULL>	598	In situ and in vivo study of bioactive agents effects on bleached enamel	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-04	Faculdade de odontologia da Universidade Federal do Pará	Faculdade de odontologia da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6wvpjq	<NULL>	60 people aged between 18 and 26 years; any genders; good health; non-smoking; pH and salivary flow within normal limits; healthy  teeth and initial color A2 or darker according to the Vita scale.	Having received previous dental bleaching ; restorations on the anterior teeth; pregnant or nursing women; having teeth darkened by tetracycline, fluorosis or endodontic treatment; patients with teeth grinding; having non-carious cervical lesion; and dentin hypersensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-7bwk89s	Effects of supervised physical exercise on functional capacity and quality of life of patients with Fontan-type circulation	Not yet recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9106	Effects of supervised cardiopulmonary rehabilitation on the functional capacity of pacientes with Fontan-type circulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Instituto Dante Pazzanese de Cardiologia	<NULL>	<NULL>	<NULL>	Age equal to or greater than 8 years; having undergone Fontan surgery at least 6 months ago; clinically stable, with the ability to perform physical exercises and functional tests	Formal contraindication to physical exercise or cardiopulmonary testing; diagnosis of severe arrhythmias, decompensated heart failure, severe lung diseases, significant motor limitations, or resting peripheral oxygen saturation below 80%	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-276rrt	Effects of Supplementation of a Component Present in Apples in Menopausal Women with Metabolic Syndrome	Recruitment completed	Intervention	2020-05-18	<NULL>	<NULL>	3841	Effects of Ursolic Acid Supplementation Associated with a Physical Activity and Nutritional Program in Women with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-276rrt	<NULL>	be female; history of spontaneous amenorrhea for a period greater than or equal to 12 months; age between 45 and 70 years; having waist circumference greater than 80 cm associated with two more parameters; fasting blood glucose greater than 100 mg/dL; triglycerides greater than 150 mg/dL, HDL-cholesterol greater than 50 mg/dL; blood pressure greater than 130/85 mmHg or use of antihypertensive drugs.	pregnant or breastfeeding women; who have musculoskeletal disorders that compromise body movement; or some serious heart disease; history of drug and alcohol abuse.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-6qr9xx	Effects of supplementation of some nutrients, in elderly, on the inflammation, the muscle, the bone and the body fat	Data analysis completed	Intervention	2016-10-10	<NULL>	<NULL>	1033	Effects of nutritional supplementation on intestine permeability, systemic inflammation and body composition consequences in elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Centro de Saúde Escola Geraldo Horácio de Paula Souza	https://ensaiosclinicos.gov.br/rg/RBR-6qr9xx	<NULL>	Elderly above 60 and below 90 years old; both genders; independent and non-institutionalized; they have to fill at least one of the following criteria of frailty: non-intentional body weight loss in the last six months; exhaustion evaluated by a geriatric depression scale; grip strength below the expected values; gait speed below the expected values; reduced energy expenditure.	Presence of acute or chronic intestinal inflammatory disease; current use of antibiotics; current use of supplements of protein, hormones or other substances driven to enhance muscle mass; current use of synbiotic, probiotic or prebiotic substances; having caner or any inflammatory disease in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-4x3gqp	Effects of supplementation with beneficial bacteria on quality of life, inflammatory profile, eating behavior, metabolism and nutritional status of patients after stomach reduction surgery	Recruiting	Intervention	2018-07-02	<NULL>	<NULL>	4491	Effects of supplementation with probiotics on quality of life, eating behavior, inflammatory, metabolic and nutritional profile of patients in the postoperative period of gastric bypass in Roux-en-Y: a randomized, double-blind study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-04-16	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4x3gqp	<NULL>	Adult inclusion criteria (18 - 59 years); both sexes; with a BMI equal to or greater than 35 kg / m2; submitted to the Roux-en-Y gastric bypass; without immediate surgical complications; who signed the TCLE	Patients submitted to other surgical techniques; patients who are undergoing reoperation or correction; patients who used antibiotics during the study period or who did not make adequate use of the placebo / probiotic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-57hj7n	Effects of supplementation with L-carnitine in the heart of patients who will do coronary artery bypass graft	Recruiting	Intervention	2015-07-30	<NULL>	<NULL>	569	Effects of supplementation with L-carnitine on ischemia and reperfusion and left ventricular function and remodeling in patients with heart failure after coronary artery bypass surgery	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-02	Universidade Federal Fluminense	Instituto Nacional de Cardiologia/INC	https://ensaiosclinicos.gov.br/rg/RBR-57hj7n	<NULL>	Sixty adult patients; lucid; oriented; both genders; minimum age of 30 years and maximum age of 80 years; diagnostic systolic ischemic heart failure; requiring elective coronary artery bypass surgery; use of cardiopulmonary bypass (CPB); Ejection fraction of the left ventricle (LVEF) greater than or equal to 50% (Simpson method); left ventricular end-diastolic volume (LV Diastolic) greater than 150 mL / m²; end of the left ventricle systolic volume (LV Systolic) greater than 65 ml / m².	During treatment develop liver dysfunction; renal dysfunction; malabsorptive syndrome; stroke; sepsis; prolonged hemodynamic shock; Patients who discontinue supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-36bjsc	Effects of supplementation with medicinal effect on the desire to eat and quality of sleep, blood glucose and cholesterol, weight loss and waist reduction	Recruitment completed	Intervention	2018-05-21	<NULL>	<NULL>	1829	Effects of supplementation with functional oils on behavioral, metabolic and anthropometric parameters in obese women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-36bjsc	<NULL>	Healthy women; obesity grade 1 and 2; who had abdominal obesity defined by waist circumference bigger then 88cm; age between 20 and 40 years	Pregnant women; smoking; with history of cardiovascular, hepatic, renal, neurological, hematological, oncological, endocrine and gastrointestinal diseases; with a history of eating disorder or who had any significant psychiatric disorder such as depression or psychosis; with a history of allergic reactions; presence of infections or use of drugs with interference in the lipid or glucose profile or those with severe dyslipidemia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-95j5pm	Effects of supplementation with vitamin D  in patients with chronic kidney disease	recruitment completed	Intervention	2012-01-30	<NULL>	<NULL>	66	Effects of supplementation with vitamin D3 in the cardiovascular system in patients with chronic kidney disease in predialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-95j5pm	<NULL>	Patients in stages 3 and 4 CKD (creatinine clearance between 59 and 15 mL/min/1.73m ²); Both genders; Aged between 18 and 75 years; Patients in the conservative treatment of CKD for at least 3 months; With serum 25 (OH) D3 &lt;30 ng/mL: And who agree to participate.	"Patients with nephrotic syndrome, liver disease, neoplastic, autoimmune or infectious activity and were seropositive for HIV;
Patients who received any supplements or vitamin D analogues, corticosteroids and immunosuppressive drugs in the last 3 months;
Patients with hypercalcemia (ionized calcium&gt; 1.40 mmol/L) and/or serum parathormone (PTH) levels&gt; 500 pg/mL; Patients immobilized in the last three months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-10gz53gy	Effects of supplementing people with natural products on improving blood parameters and immune system	Recruitment completed	Intervention	2024-06-19	<NULL>	<NULL>	7074	Development of a powder preparation containing yeast cell wall immunomodulatory molecules, turmeric, cinnamon and whey protein isolate added to probiotic culture and its effects on body mass, lipid profile and antibody levels in adult individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-11	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-10gz53gy	<NULL>	Being male; age between 25 and 45 years; non-drinkers; non-smokers; do not practice regular physical exercise; not regular consumers of cinnamon, turmeric and probiotic products; have an abdominal circumference equal to or greater than 90 (± 1 cm)	Have an allergy; intolerance to ingredients; or other type of restriction (chronic illness, medication use and acute infection)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-10xmz97f	Effects of Sustainable Acoustics in Physical Education Classes on Student Stress	Recruitment completed	Intervention	2026-01-08	<NULL>	<NULL>	8715	Sustainable acoustics in physical education classes: effects on physiological and perceptual stress responses in students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-20	Programa de pós-graduação Stricto sensu em Educação Física da Universidade Católica de Brasília	<NULL>	<NULL>	<NULL>	Adolescents of both sexes, aged between 10 and 12 years (inclusive), clinically healthy, and regularly enrolled in the final years of elementary education at the time of the study	Adolescents who are unable to adequately respond to the questionnaires; who are participating in other intervention studies during the research period; who present with cardiopathies or other medical conditions that contraindicate the performance of physical effort; who have moderate to severe hearing impairments or active otological infections; who present diseases or infections that may interfere with saliva production or with the collection and analysis of salivary cortisol; as well as those using substances or medications that may compromise sensory perception or the physiological parameters evaluated, will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-5ss7g7	Effects of sweeteners on the blood glucose and food intake	Data analysis completed	Intervention	2018-02-05	<NULL>	<NULL>	1628	Effects of high-intensity sweeteners on glycemic response and their acute impact on food intake	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5ss7g7	<NULL>	Eligibility criteria included adult (20-40 years old), eutrophic (BMI ranging from 18.5 and 24.9 kg /m2), with adequate body fat percentage (women: 20 to 30% and men: 12 to 20%), non-consumers of sweeteners and/or diet and light products (at least once a week), no smoking habits, not be pregnant or lactating and no family history of diabetes or glucose intolerance, no allergy or aversion to food tested in the study, no use of drugs that affect glycaemia or appetite, stable weight (change &lt; 3 kg in the last 3 months) and not on a weight loss diet.	Individuals outside the specified age group and body composition, smokers, pregnant or lactating women; with glycemic changes or a family history of diabetes or glucose intolerance; users of drugs that affect glycaemia or appetite, individuals with weight instability or on a weight loss diet, as well as all volunteers who express an interest in withdrawing from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-2vd6f2	Effects of swimming pool physical activities on the breathing of people with Parkinson&apos;s Disease	Recruitment completed	Intervention	2019-11-25	<NULL>	<NULL>	3230	Parkinson&apos;s Disease and Physical Therapy: Repercussion analysis of intervention programs with Terrestrial and Aquatic Physical Activities - Fisiopark	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2vd6f2	<NULL>	The inclusion criteria will be both genders; with clinical diagnosis of idiopathic PD within the stages 1 to 4 on the Hoehn and Yahr scale gravity; obtain the clinical certificate for aquatic physical activity and to attend heated swimming pool.	The exclusion criteria will be: not to present independent gait, related or not to PD; another disease that could interfere with physical assessments, such as changes in the balance of vestibular origin; visual or auditory sensory deficit that impedes accompanying verbal and visual instructions; any respiratory clinic or cardiovascular disease; history of pulmonary surgery; recent respiratory tract infection; do not agree with the consent term; relatives contraindication to frequent heated pool, such as fever, incontinence, severe blood pressure alteration, open wound; absence of more than 10% of the intervention; change in L-dopa-based drug intake parameters during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-98cknq	Effects of switched  training on the health of children and adolescents with chronic diseases	Not yet recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3408	Effects of Cross Over Training on the health related physical fitness of children and adolescents with chronic diseases: a randomized clinical trial.	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2019-11-20	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - FMRP-USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - FMRP-USP	https://ensaiosclinicos.gov.br/rg/RBR-98cknq	<NULL>	Confirmed diagnosis of chronic diseases; patient with spina bifida;Duchenne muscular dystrophy;Charcot Marie Tooth;congenital dystrophy;congenital myopathy;independent walk; use assistive device;use of wheelchair; age between 8 to 16 year old;answer no to all PAR-Q questions; have less than two risk factors for coronary heart disease from the questionnaire;patients who could develop a maximum cardiopulmonary exercise test confirmed by physician;patients able to follow the instructions;patients with voluntary participation in the research	Patients with comorbidities associated with underlying disease that prevent maximum exertion;  recent upper limb fracture;history of hydrocephalus that compromises understanding or lead to neuromuscular changes and cause motor incoordination to perform the tests;children and adolescents whose guardians do not agree to sign the Informed Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-262xftk	Effects of Systemic Photobiomodulation Therapy on Lipedema	Recruiting	Intervention	2026-01-14	<NULL>	<NULL>	8753	Therapeutic effects of Systemic Photobiomodulation in Lipedema	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Centro Universitário das Faculdades Associadas de ensino - FAE	<NULL>	<NULL>	<NULL>	Female volunteers; aged between 18 and 42 years; diagnosed with lipedema in the lower limbs; agree to participate and sign the informed consent form	Pregnant women; individuals with hemophilia, bleeding disorders, or skin tissue abnormalities; individuals with rheumatological pathologies; individuals with diabetes mellitus or decompensated systemic metabolic disorders; those belonging to other research groups in the same study area and/or undergoing treatment for the pathology with another methodology; individuals with cancerous alterations; refusal to sign the informed consent form; health disorders known to be related to the onset of menopause and/or perimenopause; endocrine disorders not related to sex hormones but which are not adequately controlled; those who have undergone cosmetic surgery in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-66gqfs	Effects of Taking Fluids before Surgery in gynecological patients	Recruitment completed	Intervention	2018-04-18	<NULL>	<NULL>	1722	Effects of Preoperative Fasting in gynecological patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66gqfs	<NULL>	women; age between 18 and 70; body mass index less than 40 kg/m2; have a pre-anesthetic evaluation with a classification without surgical risk taking into consideration the classification of the American Association of Anesthesiology.	patients with gastrointestinal, respiratory, C-reactive protein levels greater than 6mg/dL; time of surgery greater than 4 hours, use of steroids for more than 6 months before surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-3hsj6g6	Effects of Tamsulosin on semen parameters	Data analysis completed	Intervention	2021-09-20	<NULL>	<NULL>	7868	Effects of Tamsulosin on ejaculation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-20	Faculdade de Medicina do ABC	Instituto Ideia Fértil de Saúde Reprodutiva	https://ensaiosclinicos.gov.br/rg/RBR-3hsj6g6	<NULL>	Men aged 18 to 45 years; with the ability to perform sperm collection; who accept to participate as volunteers in the research	History of neurological changes even if treated; history of liver disease; history of kidney disease; history of use of exogenous testosterone or anabolic or androgen; history of diabetes mellitus; history of pelvic or genital surgery; concomitant use of specific medications (ketoconazole  erythromycin   other alpha blockers  warfarin and diclofenac); inability to collect sperm by masturbation; sperm changed according to WHO standards; negative to sign a free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-54pbt6	Effects of taping in pain and function  of patients with knee arthrosis: a blind randomised clinical trial	Recruitment completed	Intervention	2015-10-22	<NULL>	<NULL>	640	Effectiveness of taping in pain and functional capacity of patients with knee osteoarthritis: a blind randomised clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-13	Universidade Federal de São Paulo	AACD - Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-54pbt6	<NULL>	74 Adult patients (18 from 80 years) referred AACD - Lar Escola São Francisco diagnosed with moderate knee osteoarthritis and agree to participate in the study according to the term informed consent	Patients with rheumatic diseases associated; orthopedic surgery of the lower limbs; prior injections of steroids in the past six months; obesity (BMI&gt; 35);allergy to components of physiotherapy; those who underwent physiotherapy in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-10mdc4h7	Effects of taurine consumption on the physical performance of professional soccer players	Data analysis completed	Intervention	2025-01-23	<NULL>	<NULL>	7678	Effects of acute Taurine consumption on physical performance parameters in professional soccer athletes: a triple-blind, randomized, crossover clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-23	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10mdc4h7	<NULL>	To be a football (soccer) athlete; participate in the Under-20 category (ages 17 to 20); be involved in football competitions; have at least two years of formal and systematic experience in the sport prior to the start of the study	Presence of bone and/or muscle injury; history of recent musculoskeletal injuries; use of anti-inflammatory medication; use of taurine or caffeine-based supplements 24 hours before the protocols; presence of any disease in the central nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-8yvhdzj	Effects of TDCS on late muscular pain after resisted training	Not yet recruiting	Intervention	2023-03-15	<NULL>	<NULL>	5948	Effects of Transcranial Direct Current Stimulation (TDCS) on late muscular pain after resisted training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Faculdade de Ciências da Saúde do Trairí- Universidade Federal do Rio Grande do Norte (FACISA/ UFRN))	Faculdade de Ciências da Saúde do Trairí- Universidade Federal do Rio Grande do Norte (FACISA/ UFRN))	https://ensaiosclinicos.gov.br/rg/RBR-8yvhdzj	<NULL>	sedentary young adult men, recommended by the american college of sports medicine; absence of neurological or rheumatic disease known as rheumatoid arthritis, gout, lupus, and chronic chikungunya; age between 18 and 30 years; availability and interest in participating in the study and not being on analgesic and antinflammatory medication	history of seizures or epileptic illness; metallic implants in the head or neck; having exercised regularly in the last 3 months; acute inflammation of the upper respiratory tract; dental treatment within the last 4 weeks; use of nicotine, coffee or alcohol on the day of the assessment; physical activities as examples cited; walking to college, going up and down stairs, washing clothes, sweeping, up to 2 hours before the assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-3q7szpv	Effects of Teleconsultation for the care of children with feeding difficulties	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7738	Effects of a Teleconsultation program on the quality of care for parents and caregivers of children with Dysphagia: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3q7szpv	<NULL>	Third, a non-progressive neurogenic disorder medical diagnosis, and a neurogenic dysphagia clinical diagnosis; Ser pacientes attended no ambulatório Gastropedriatria do Hospital das Clínicas da Universidade Federal de Pernambuco; Fazer parte dos casos identificados no ano de 2024 no respectiveo serviço; Aceitar participar da teleconsulta e do estudo.	First consultation; Do not accept consultation via video call.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3w3vnc	Effects of telephone interventions on adherence to receive the results of examination of prevention of cervical cancer	Recruitment completed	Intervention	2016-01-07	<NULL>	<NULL>	677	Effects of educational and behavioral intervention by telephone on accession to receive the Pap smear report	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-30	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3w3vnc	<NULL>	Have initiated sexual activity; take the examination for the prevention of cervical cancer in the period of data collection and own mobile or landline.	A minor; present some pathology related to mental processes, speech articulation or hearing that it would not answer the questionnaire and to participate in educational or behavioral intervention; not have done for any reason, the Pap test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-86yn4b	Effects of telephone use to promote the health of people living with HIV/AIDS	Recruiting	Intervention	2017-07-10	<NULL>	<NULL>	1284	Effects of a telephone follow-up program to promote the health of people living with HIV/aids	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-15	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-86yn4b	<NULL>	Adults being treated for HIV; Both genders;age between 18 and 59 years.	Diminished visual acuity; dysarthria; accused; Mental disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8f8yk8h	Effects of telepractice in Speech and Language Pathology on orofacial myofascial pain	Recruiting	Intervention	2022-04-12	<NULL>	<NULL>	5341	Effects of telecare focusing on chewing and swallowing functions on orofacial myofascial pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-17	Universidade Federal de Minas Gerais - UFMG	Pontifícia Universidade Católica de Minas Gerais - PUC Minas	https://ensaiosclinicos.gov.br/rg/RBR-8f8yk8h	<NULL>	Diagnosis of orofacial myofascial pain with spreading or referred according to CD-TMD (Diagnostic Criteria for Temporomandibular Disorders); age between 18 and 30 years; pain intensity higher then 4 by the numerical visual scale for at least 3 months prior to recruitment, having access to internet and the platform that will be used for teleterapy, signing the free and informed consent form (ICF).	Gestation; absence of central and lateral incisor teeth; presence of: dental pain, periodontal changes, previous or current tumor or major trauma in the head and neck region, edentulism, use of complete dentures and current orthodontics; diagnosis of fibromyalgia; presence of arthralgia, current myofunctional treatment or any other type of treatment for temporomandibular disorders; treatment for sleep disorders; continuous use of non-steroidal anti-inflammatory drugs, analgesics, antidepressants or central myorelaxant drugs; use of bronchodilators and vasoactive medications; presence of fever, allergic rhinitis, flu and/or cold symptoms; presence of neurological or cognitive impairments; use of a bandage on the skin and/or other factors that prevent its exposure to a balanced temperature environment at the time of data collection; performing physical exercises, acupuncture, massages, electrical stimulation, having attended saunas or being exposed to the sun for a long time on the day of the evaluation; not agreeing to participate in the research and refusing to sign the informed consent, as well as not carrying out the activities requested at the time of evaluation and therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-3kzr42p	Effects of telerehabilitation on knee osteoarthritis	Recruiting	Intervention	2024-01-07	<NULL>	<NULL>	6707	Effects of two Telerehabilitation programs to improve the health status of people with knee Osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3kzr42p	<NULL>	Both sexes; over 40 years old and under 75 years old; clinical or radiographic diagnosis of knee osteoarthritis; symptomatic for at least 3 months; with internet access via smartphone, willingness to participate in the research and who sign the informed consent form (TCLE)	Arthroplasty or previous knee surgeries; another reason for the joint symptoms such as a tumor, inflammatory joint disease, or patellar tendinopathy; other symptoms more pronounced than osteoarthritis symptoms such as chronic widespread pain or fibromyalgia; cardiovascular, respiratory or neurological medical restrictions that make it impossible to participate in this study; inability to walk, go up and down stairs, sit down and stand up, cognitive impairment and who are undergoing physical therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-8rtzfn	Effects of tens (muscular surface electrical stimulation) on walking distance, function, function of the heart&apos;s nervous system and cardiorespiratory fitness of individuals with Peripheral Arterial Disease: a randomized clinical trial	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2561	Effects of tens on walking distance, functional capacity, autonomic cardiovascular function and cardiorespiratory fitness of individuals with Peripheral Arterial Disease: a randomized clinical trial	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal de Minas Gerais	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora - SUPREMA	https://ensaiosclinicos.gov.br/rg/RBR-8rtzfn	<NULL>	To be included he must initially sign the free and informed consent form. There may be no claudicating pain of non-vascular origin; uncontrolled diabetes; uncontrolled hypertension; chronic kidney disease diagnosed; acute myocardial infarction in the last three months; history of recent pulmonary embolism; neuromuscular changes that limit the functional capacity; exercise tolerance primarily limited by factors other than the claudicating symptom and cardiovascular physical therapy in the last three months.	Individuals unable to understand and perform procedures with the measurement is with higher blood pressure (BP) values superior to 200 / 110 mmHg and heart rate (HR) greater than 120 bpm;  and HR &gt; 85% of maximal predicted by age during exercise testing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-6w5tbk	Effects of tests for covid-19 on the preservation of the healthcare workforce during pandemia in Brazil	Not yet recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3781	Effectiveness of a protocol based on rt-pcr and serology tests for sars-cov-2 for the preservation of the healthcare workforce during covid-19 pandemia in Brazil: a parallel group, randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-30	Hospital Universitário de Brasília	Cleandro Pires de Albuquerque	https://ensaiosclinicos.gov.br/rg/RBR-6w5tbk	<NULL>	Healthcare professional; directly involved in the care of patients; temporarily removed from work, because of suspected COVID-19 due to respiratory symptoms or fever	Age greater than 60 years; diabetes; cardiopathy; chronic lung disease; chronic kidney disease; onco-hematological diseases in the last five years; immunossupression; compromised general health; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-8trwmwd	Effects of the amount of muscle mass involved in aerobic exercise on state anxiety level in young women exposed to unpleasant stimuli	Not yet recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6305	Effects of the amount of Muscle Mass involved in Aerobic Exercise on State Anxiety level in young women exposed to Unpleasant Stimuli	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8trwmwd	<NULL>	Women; aged between 18 and 40 years	Are in menstrual period; pregnant; contraindication for performing physical activity (PAR-Q); anxiolytic treatment of any kind; dysfunction (cardiac, endocrine, orthopedic and metabolic) self-reported that may interfere with performance; are not literate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-104xsgky	Effects of the Animal Fun Program on movement and psychosocial performance in children aged between 4 and 6 years	Not yet recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5724	Effects of the Animal Fun Program on motor and psychosocial performance in children aged between 4 and 6 years	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-104xsgky	<NULL>	Children aged 4 to 6 years old can participate in the Animal Fun programme; enrolled; signed informed consent form (TCLE) and assent form (TELE).	not being able to perform the Movement Battery Assessment for Children (MABC-2).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-3vnwnq	Effects of the application of educational technology for guidance of parturient companions	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2707	Effects of educational technology for guiding female followers in labor in a reference maternity hospital in Fortaleza-Ceará	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Maternidade Escola Assis Chateaubriand	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-3vnwnq	<NULL>	healthy volunteers; both genders; older than 18 years; chosen by the pregnant women to participate in delivery as companions.	volunteers with cognitive impairment that prevented them from understanding the orientations that were being addressed; be accompanied by pregnant women with fetal death; companions of women who presented obstetric complications that contraindicated the use of non-pharmacological methods of pain relief.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-6wq24d	Effects of the application of Therapeutic Ultrasound associated with Eletrical Stimulation  in Pain and Funcionality in women cesarian section	Recruitment completed	Intervention	2020-06-15	<NULL>	<NULL>	3924	Combined Therapy (Ultrasound and Transcutaneous Eletrical Nerve Stimulation) improves Pain and Functional Limitation in post cesarean: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-23	Universidade Federal Do Paraná	Maternidade Victor Ferreira do Amaral do Complexo do Hospital de Clínicas	https://ensaiosclinicos.gov.br/rg/RBR-6wq24d	<NULL>	Women over 15 years of age;underwent cesarean during labor for at least 8 hours and a maximum of 24 hours after the procedure; post-cesarean pain	illiterate or non-oriented; presence of puerperal intercurrences such as: local bleeding requiring intervention, signs suggestive of infection, fever, anesthetic complications and breast intercurrences; diagnosis of epilepsy, demyelinating disease, spindle trauma, tumors, diabetes mellitus and hypertension; puerperal women who use pacemakers or implanted electronic devices; presence of local drainage system and;  irritation or intolerance to the application of Combination Therapy (history of allergy or intolerance to the application of electrical current or therapeutic ultrasound)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-2txw8zy	Effects of the Aquatic Exercise Training on Health of Adults and Elderly	Recruiting	Intervention	2023-01-17	<NULL>	<NULL>	6580	Effects of the Aquatic Training in Upright Position on Hemodynamic, Metabolic, Functional and Psychosocial Outcomes in Adults and Elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-11	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2txw8zy	<NULL>	Be a participant in the Vertical Position Water Activities program; have medical authorization to practice physical exercise	Do not be disponible time for participate; have osteomioarticular limitations that may impair the execution of the exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-72vws64	Effects of the association of an Intensive Physical and Behavioral Therapy and the Feedback of Movement Imagination on the functionality of the severely upper limb affected by Stroke: a clinical, controlled, randomized and blinded trial	Recruiting	Intervention	2022-11-14	<NULL>	<NULL>	5721	"Effects of the association of Constraint Induced Therapy and the Brain Interface
Machine in the functionality of the severely upper limb affected by Stroke: clinical, controlled, randomized, blinded trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-18	Universidade Cidade de São Paulo	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-72vws64	<NULL>	Stroke more than six months before the beginning of the protocol; age between 18 and 80 years; hemiparesis as a sequela of stroke; score on the Fugl Meyer scale for the upper extremity ≤53 points (moderate and severe injuries), but present at least 30º of shoulder flexion and/or abduction and 10º of elbow extension (from 90º flexion), as well as, greater impairment in the hand most affected by the stroke, evidenced by the deficit in the active extension of the fingers of the hand most affected by the stroke (towel test: should not be able to pick up a face towel from a table and release it more than three times in a minute ); finger flexor tone of the most affected hand &lt;3, assessed by the Modified Ashworth scale; ability to understand simple commands and instructions for assessments and intervention protocols; be available to attend assessments and therapy for 15 consecutive days and remain 3 hours/day in treatment	Inability to interrupt other physical therapies during intervention protocols; language alteration that makes the participant unable to understand, as well as respond appropriately to the proposed assessment scales, interaction with the brain-machine interface and the exercises selected for each protocol; surgery less than 6 months ago, chemical block in the upper limb most affected by stroke less than 3 months ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-3fvm6v	Effects of the association of the use of cholesterol-lowering medication and regular practice of physical exercise in people infected with HIV	Not yet recruiting	Intervention	2016-12-28	<NULL>	<NULL>	1123	Association betwwen statin and regular physical activity in people infected by HIV: randomized clinical trial, double-blind and placebo-controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3fvm6v	<NULL>	Being HIV-infected and using antiretroviral therapy for more than a year and being dyslipidemic. Be over 18 years and less than 60. Have health conditions for the practice of the proposed physical exercises. Be sedentary. Have trip availability three times a week to the training location.	Having diagnosis of opportunistic infections in the last two years. Having a diagnosis of liver disease and/or nephropathy and/or neuropathy. Have a history of orthopedic surgery. Have an body mass index&gt; 30 kg / m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-2mmfhx	Effects of the biometenergy of practitioners of meditation on chronic spine pain	Data analysis completed	Intervention	2016-05-27	<NULL>	<NULL>	865	Effects of the biometenergy of practitioners of pranic meditation on the evolution of chronic diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-02	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-2mmfhx	<NULL>	Volunteers, both genders, with back pain longer than 3 months, recent medical report, older than 18 years old, no previous participation of pranic meditation courses and no have any knowledge about the techniques of pranic meditation, and the written informed consent	Smokers; alcohol users; pracitioners of pranic meditation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-3djfww	Effects of the blood occlusion technique performed before sports performance tests and strength assessment on the lower limbs of college soccer players: experimental, controlled and randomized research	Not yet recruiting	Intervention	2020-10-02	<NULL>	<NULL>	4322	Effects of Ischemic Preconditioning  on the functional and neuromuscular performance of lower limbs in university soccer players: a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-20	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3djfww	<NULL>	The study will be attended by men, university football players from the city of Natal / RN aged between 18 and 35 years old who regularly train and play football at least 3 times a week. The following will not be included: subjects with body mass index (BMI) less than 18.5 kg / m-2 and greater than 30 kg / m-2; with musculoskeletal injury in the lower limbs in a period of three months before the tests; with lower limb surgery within six months of testing; with uncontrolled metabolic diseases; with inflammatory rheumatological condition or severe cardiovascular and / or pulmonary disease that prevents them from carrying out the proposed evaluation and tests.	The exclusion criteria adopted were: missing a research data; at any time and for any reason expressing a desire to leave the study; present a health problem that prevents them from continuing to participate in the research; use drugs or any therapeutic resources to improve performance or practice unusual or strenuous physical activities during research period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-77f8rjq	Effects of the combination of Electrical Stimulation and Exercise on pain, strength, and mobility in people with knee Osteoarthritis	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8498	Effects of adding Neuromuscular Electrical Stimulation to Resistance Exercise on pain, self-reported physical function, muscle torque, and performance-based physical function in patients with knee Osteoarthritis: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-30	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Participants with a diagnosis of knee osteoarthritis according to the clinical criteria of the American College of Rheumatology; aged 18 years or older; no gender restrictions	Secondary knee osteoarthritis (e.g., septic arthritis, inflammatory joint disease, gout, articular fracture, severe dysplasias, congenital abnormalities, or hemochromatosis); systemic arthritic conditions; history of arthroplasty or other surgical interventions in the knee or hip; associated neurological diseases that impair lower limb function (such as post-stroke, neuropathies, or multiple sclerosis); contraindications and precautions related to neuromuscular electrical stimulation, including patients with pacemakers or cardiac defibrillators, deep vein thrombosis, areas with diagnosed or suspected malignancies, active bleeding, infection, skin disease, areas with impaired sensation, or pregnancy; intra-articular corticosteroid injection within the past three month	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:42
RBR-7y35v6	Effects of the combination of strengthening exercises and blood flow block on hand strength gain	Data analysis completed	Intervention	2019-10-21	<NULL>	<NULL>	3114	Comparison of different strengthening protocols associated with blood flow restriction to increase handgrip strength	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-15	Universidade Federal de Santa Catarina- UFSC	Universidade Federal de Santa Catarina- UFSC	https://ensaiosclinicos.gov.br/rg/RBR-7y35v6	<NULL>	Female volunteers; aged between 18 and 25 years old; students; and able to perform the proposed activities were included.	Volunteers with a history of forearm injury that compromised muscle integrity; or who had a history of fractures in the wrist and fingers, upper limb pain; hypertensive patients; heart disease; cognitive impairment; manual workers; and practitioners were excluded of physical activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-6w9nfq	Effects of the combination of visual or auditory cues to treadmill gait training of individuals who have suffered stroke	data analysis completed	Intervention	2012-05-11	<NULL>	<NULL>	128	Influence of biofeedback in gait training on a treadmill with partial body weight support in hemiparetic subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-01	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-6w9nfq	<NULL>	"Chronic stage of stroke (time of injury over 6 months); 
Hemiparesis; unilateral brain lesion and non-recurring, mild to moderate spasticity, with level 1 or 2 of the modified Ashworth scale;
Ability to ambulate functionally, with some assistance or personal with the use of assistive devices for walking, levels 4 and 5 of the protocol Functional Ambulation Category - FAC; 
Idling (slower than 0.4 m / s) or moderate (speed from 0.4 to 0.8 m / s) according to the classification of gait based on speed;
Absence of cognitive impairment, from the score of the Mini Mental State Examination (MMSE);
Absence of other neurological or orthopedic pathologies that lead to functional sequelae than those brought by stroke or disability visual and/or hearing loss that adversely affects the training of biofeedback."	"Instability in the cardiovascular condition during training;
Lack of understanding of instructions for carrying out training"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-835555x	Effects of the consumption of Coffee with Cocoa and Cinnamon in the cardiovascular health	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6394	Cardiovascular effects of consumption of Coffee formulations enriched with Cocoa and Cinnamon: ECARDIO-CACACA study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-10	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-835555x	<NULL>	Be aged between 18-80 years; Mini-Mental State Examination ≥ 27 points; ≥ 22 points (person with 1-11 years of education) and ≥ 9 points (illiterate person); female patient; have telephone contact; Not allergic to products derived from cocoa, coffee and/or cinnamon; Have been diagnosed with high blood pressure for at least six months; Living in the health territory.	Being a chronic user of glucocorticoid and/or psychotropic drugs; Being a user of ≥ 3 different pharmacological classes of antihypertensive drugs; Being afflicted with diabetes; Being pregnant or breastfeeding; Being a woman with a history of osteoporosis; Having been submitted to some surgical treatment less than 30 days ago; be a smoker; Have severe kidney, liver, or cardiovascular problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-5mv7jd	Effects of the consumption of white or red grape juice in the muscular damage of rugby athletes	Recruitment completed	Intervention	2019-10-31	<NULL>	<NULL>	3157	Effects of consumption of white or red grape juice on oxidative stress and muscular fatigue in rugby athletes: A randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-02	Centro Universitário Metodista	Centro Universitário Metodista	https://ensaiosclinicos.gov.br/rg/RBR-5mv7jd	<NULL>	Male players will be included, aged between 20 and 30 years and at least 1 year play as holders of the rugby team of Caxias do Sul / RS and have daily training routines, between the game itself and physical training.	Injured athletes who are out of training and / or competing in the past six months, athletes using anti-inflammatory drugs, and athletes who have an aversion or allergy to the components of grape juice will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-9zggxm	Effects of the decreased carbohydrate intake in short-stature, excess weight women	Recruitment completed	Intervention	2015-07-19	<NULL>	<NULL>	550	Low-carbohydrate diet effects on women with excess weight and short-stature	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Universidade Federal de São Paulo	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-9zggxm	<NULL>	Women; age between 20 and 45 years old; height less than 152,3 cm or higher than 158,7cm; body mass index higher than 25kg/m².	Individuals in Continuous use of drugs (immunosuppressors, insulin, thyroid hormones, anti-retrovirals); pregnant or lactating.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-67k9qkp	Effects of the Elastic Bandage on the breathing of young adults	Recruitment completed	Intervention	2021-08-06	<NULL>	<NULL>	4819	Immediate effects of Elastic Banding on Thoracoabdominal Expandability, Vital Capacity and Respiratory Muscle Strength in young adults	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-67k9qkp	<NULL>	Aged between 18 and 25 years; body mass index (BMI) until 30 kg / m2; non-smokers; with no report of chronic respiratory disease; with no report of acute infection of airways; who do not practice activity regularly.	Allergy to tape or elastic bandage; arthrodesis; spinal deformities; previous rib fractures; surgery on the rib cage; neuromuscular diseases; individuals who do not understand or are unable to carry out the evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-9msy3t	Effects of the elastic bandage on the symptoms of medial tibial stress syndrome in runners	Not yet recruiting	Intervention	2015-08-17	<NULL>	<NULL>	588	Effects of the elastic bandage on the symptoms of medial tibial stress syndrome in runners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9msy3t	<NULL>	Sixty athletes that run during their training; the run training occurs at least three times a week; presence of the medial tibial stress syndrome induced by sports practice for at least six weeks and pain on palpation in the distal posteromedial border of the tibia.	Suspicion of tibial stress fracture or compartment syndrome; history of surgery in lower limbs or tibia fracture; paresthesia; other conditions that cause pain in the leg or presence concurrent pain; such as pain in the knee or ankle sprains.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-3zmh3r	Effects of the inclusion of a Functional Circuit to Aerobic and Resistance Training on functionality, physical activity in daily life and inflammation of patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	2544	Effects of the inclusion of a Functional Circuit to Aerobic and Resistance Training on functionality, physical activity in daily life and immuno-metabolic response of patients with Chronic obstructive pulmonary disease (COPD): a randomized clinical trial with follow up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Estadual Julio de Mesquita Filho - UNESP	Ercy Mara Souza Ramos	https://ensaiosclinicos.gov.br/rg/RBR-3zmh3r	<NULL>	patients diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD); clinically stable patients without exacerbations or changes in medications for at least 30 days; they are not smokers; patients who do not undergo home oxygen therapy;  patients without pathological conditions that prevent physical activity; no severe or unstable heart disease diagnosed by electrocardiogram; does not present any other pathological condition that may influence the systemic inflammatory process; not participating in another systematic exercise program.	Exacerbations or intercurrences that prevent the continuity of the training protocol; frequency of less than 75% of the sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-9jd7b7	Effects of the intensity of Interval Training on aerobic fitness, body composition and resting metabolic rate of women with Overweight or Obesity: a randomized controlled trial	Data analysis completed	Intervention	2020-05-06	<NULL>	<NULL>	3815	Effectiveness of two different Training approaches in body composition (cc) and cardiorespiratory resistance (rc) in an interdisciplinary program for adults with Overweight or Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Centro Universitário de Maringá	Centro Universitário de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-9jd7b7	<NULL>	Volunteer women; aged between 18 to 45 years; sedentary; body mass index equal or greater than 25 kg/m2; stable body weight in last three month.	Comorbidities or pathologies associated, except those of metabolic syndromes; use of medications and/or supplements to weight-loss; performing a restrictive diet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-6pygc5m	Effects of the Laser on the lips	Recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7260	Effects of Myotherapy combined with Photobiomodulation on the lips: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal de Minas Gerais	Universidade Vale do Rio Doce	https://ensaiosclinicos.gov.br/rg/RBR-6pygc5m	<NULL>	Healthy individuals of both genders; aged between 18 and 35 years; who have signed the Informed Consent Form (ICF); have not used muscle relaxants and/or anti-inflammatory medication in the 48 hours preceding data collection; participants without contraindications for phototherapy	Non-execution of all proposed tasks; low quality of electromyographic signal; not have dento-skeletal conditions to perform lip sealing or those who; lip sealing with effort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-3dvy84p	Effects of the muscle relaxant Cyclobenzaprine on the chewing muscles activity during sleep	Recruiting	Intervention	2025-03-06	<NULL>	<NULL>	7818	Effects of Cyclobenzaprine on rhythmic masticatory muscle activity during sleep: proof of concept for a randomized placebo-controlled crossover trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-01-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3dvy84p	<NULL>	Volunteers of both sexes; age between 18 and 50 years; self-reported teeth clenching and/or grinding during sleep (at least once a week in the last month) or sleep partner or family-reported clenching and/or grinding in the past 3 months; dental wear compatible with possible sleep bruxism, based on clinical evaluation; secondary manifestations related to sleep bruxism, such as discomfort/tension/facial pain (excluding persistent headache or migraine), temporal headache, or jaw locking upon waking; frequent history of tooth or restoration fracture; clinical signs of tongue mucosa indentation and masseter muscle hypertrophy	History of dizziness and syncope; sensitivity to drowsiness induced by alcohol and medications such as muscle relaxants and anxiolytics; history of any type of heart disease, such as tachycardia, arrhythmia, heart failure, and myocardial infarction; diagnosis of obstructive sleep apnea-hypopnea syndrome, periodic limb movement disorder, and insomnia; liver dysfunction; diagnosis of hyperthyroidism or hypothyroidism; pregnancy or suspected pregnancy, postpartum and breastfeeding, as well as the use of oral contraceptives and/or other related methods; use of anxiolytics, antidepressants, sleep inducers, analgesics, and monoamine oxidase inhibitors in the last 14 days; history of cannabis use; report of persistent intense headaches, migraines, facial pain, and temporomandibular joint pain that interfere with daily activities; limited mouth opening of less than 25 mm; history of allergy to electrode gel adhesive; history of severe and persistent gastroesophageal reflux​	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-9v7bx4h	Effects of the online mindfulness protocol for college students	Recruiting	Intervention	2021-10-21	<NULL>	<NULL>	4996	"Evaluation of the Effects of the Online Version of the MBRP Protocol
(Mindfulness-Based Relapse Prevention) Adapted for University Students."	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-11	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9v7bx4h	<NULL>	Undergraduate or graduate university students in the health area, both genders, between 18 and 30 years old who have access to the internet.	Participants who present a clinical situation of psychotic disorder, severe cognitive impairment and/or have already completed a mindfulness group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-5zm9pr	Effects of the Open Lung Concept following ARDSnet Ventilation in Patients with Early ARDS	Data analysis completed	Intervention	2015-11-04	<NULL>	<NULL>	647	Evaluation of a Sequential Ventilatory Strategy in Patients with Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-04	Universidade de São Paulo	Hospital Copa Dor	https://ensaiosclinicos.gov.br/rg/RBR-5zm9pr	<NULL>	Patients with the diagnosis of Distress Respiratory Syndrome presenting PaO2/FIO2 lower than 300 mmHg after 30 min of mechanical ventilation with a PEEP of 5 cmH2O and an FIO2 of 1.0 and a VT ranging from 8 to 10 mL/kg of ideal body weight along with hemodynamically stable parameters (mean arterial pressures higher than 65 mmHg and arterial lactates lower than 3 mg/dL) over the preceding 6 hours.	Patients with the diagnosis of Adult Distress Syndrome for more than 48 h. Diagnosis of pneumothorax. Diagnosis of pneumomediastinum. Bronchopleural fistula. Subpleural blebs. Increased intracranial pressure. Body weight greater than 140 kg. Pregnancy. Coexistent disease with an expected 6-month mortality risk exceeding 50%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-392cxdp	Effects of the physiotherapy in the motor functions and quality of life in Parkinson&apos;s disease	Recruitment completed	Intervention	2022-08-19	<NULL>	<NULL>	5565	Effects of a physiotherapy treatment protocol for motor functions and quality of life in Parkinson&apos;s disease: experimental study	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2017-10-01	Unidade Universitária Goiânia-ESEFFEGO Universidade Estadual de Goiás	Unidade Universitária Goiânia-ESEFFEGO Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-392cxdp	<NULL>	Parkinson&apos;s disease or Secondary Parkinsonism, diagnosed at least six months ago, in stages 1, 2 or 3 of the Hoehn and Yahr (HY) scale or with an equivalent motor condition, in the case of secondary parkinsonism; Walks with total or modified independence; Age between 40 and 70 years, under medical supervision for at least 2 months; Medical authorization for the practice of exercises; Makes regular use of antiparkinsonian medication.	Surgery for Parkinsonism; Cardiovascular diseases or musculoskeletal disorders (rheumatological, orthopedic, traumatological, arthrodesis) that contraindicate physical exercise; Great limitation of joint movement in any body segment; Secondary balance disorders, such as severe vestibulopathies; Severe cognitive impairment, which prevented the understanding of verbal instructions, confirmed by the Mini Mental State Examination (MMSE), with a score lower than 24 points (8 years of schooling), less than 18 points (4-7 years of schooling) or less than 14 points (illiterate people).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-7jtf787	Effects of the Pilates Method and Circuit Training on the motor and cognitive function of the elderly	Recruitment completed	Intervention	2022-07-26	<NULL>	<NULL>	5509	Comparison of the Effects of two types of intervention, Pilates Method and Coordinative Motor Circuits, on variables of motor and cognitive behavior in senior citizens in the São Francisco Valley region: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-03	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7jtf787	<NULL>	Age 60 years or older; agree to participate in the study; no exacerbations or debilitating infections in the past three months; no contraindications to testing; not have neuromuscular diseases that present motor deficit, such as Stroke, Multiple Sclerosis, Amyotrophic Lateral Sclerosis or Guillain-Barré.	Accident during training that makes it impossible to continue the program; three consecutive absences in the intervention sessions; total frequency less than 25%; frequent delays that compromise the evolution of training; developing a disease that makes it impossible to exercise; withdrawal; difficulty in understanding the procedures proposed by the researchers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-2h8ng8b	Effects of the Pilates method on cardiorespiratory system of Hypertensive elderly individuals	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8364	Cardiorespiratory effects of the Pilates method in Hypertensive elderly individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-12	Universidade Federal de São Paulo	Physio&amp;Pilates Guarujá LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2h8ng8b	<NULL>	Hypertensive elderly individuals with a medical report; of both genders; Hypertension controlled by medication; sedentary; with medical clearance to practice physical exercises; without injuries that compromise the training program; who agree to volunteer for the research	Elderly individuals with medication changes during the experimental period; with an attendance rate lower than 75% in the training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-4ym2j4	Effects of the Pilates Method on the Overall Health of the Elderly	Recruitment completed	Intervention	2019-07-12	<NULL>	<NULL>	2818	Effects of the Pilates Method on morphological, functional and psycho-behavioral variables in the elderly of the university community of the Federal University of Bahia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4ym2j4	<NULL>	individuals capable of practicing physical activity;aged between the ages established; individuals who present good cognitive ability and are able to respond to the study questionnaires and perform the proposed tests.	diseases and / or physical / motor and / or intellectual problems and symptoms that make it impossible to apply the questionnaires and / or to carry out evaluative tests and the intervention activities proposed for this study and are outside the established age range	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-5wkdk7	Effects of the pressure of the hands on the chest to remove secretions from the lung in patients on life support	Recruiting	Intervention	2014-11-26	<NULL>	<NULL>	354	Effects of chest compression in patients on mechanical ventilation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5wkdk7	<NULL>	Patients of both genres; aged between 18 and 80 years; in use of an endotracheal tube or tracheostomy; receiving ventilatory support; sedated; hemodynamically stable; no active participation in the fan; having diagnosed the presence of lung infection	History of pulmonary disease; hemodynamic instability; abnormalities of the chest or abdominal wall; obesity; severe scoliosis; pregnancy; cardiac pacemaker; pneumothorax; flail ches;, presence of vascular fragility; acute respiratory distress syndrome; thrombocytopenia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-6cywff	Effects of the resistance exercise on muscle and vascular function in older adults with reduction of muscle strength and mass.	Recruitment completed	Intervention	2020-01-06	<NULL>	<NULL>	3331	Effects of a low-intensity resistance exercise program with vascular occlusion on muscle function and microcirculation in older people with Sarcopenia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)	Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)	https://ensaiosclinicos.gov.br/rg/RBR-6cywff	<NULL>	Age 65 to 100 years without regular physical activity for at least six months with sarcopenia.	Muscle problems; cardiovascular diseases; obesity; smoking; cancer; diabetes mellitus; autoimmune diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-86dtnz	Effects of the restorative material in atraumatic restorations	Recruitment completed	Intervention	2016-01-14	<NULL>	<NULL>	682	A 24-month randomized clinical trial of ART restorations in Class II cavities with two glass ionomer cements	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-20	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-86dtnz	<NULL>	Students aged 4 to 12 years, of both genders and having deciduous and/or permanent teeth with caries lesions involving the proximal surface, visible during clinical examination and classified as score 05 ICDAS (International Caries Detection and Assessment System); the cavities should have an occlusal opening compatible with the sizes of the dentin excavators according to the ART technical protocol.	Students with deciduos and/or permanent teeth with pulp pathology characterized for facial edema and fistula, volunteers whose parents do not agree with the Informed Consent Form, non-collaborative children, volunteers with special needs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-2dc8kz	Effects of the selective strengthening technique for the internal musculature of the foot in type II diabetic volunteers. Randomized and controlled study	Not yet recruiting	Intervention	2019-10-17	<NULL>	<NULL>	3104	Effects of the selective strengthening technique for intrinsic skin musculature in diabetic volunteers of type II. Randomized and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2dc8kz	<NULL>	Type II diabetes mellitus, according to American Diabetes Association criteria; between 20 and 70 years old; of both sexes; in diet therapy or with oral antidiabetic drugs  and signing the term of free and informed consent.	Individuals with type II DM with very high risk, ie those with previous ulcers and / or amputations, clinical diagnosis of hemiplegia, paraplegia, or Parkinson&apos;s disease; limb amputation; a history of alcohol or drugs; a herniated disc; leprosy; severe arthritis that prevents walking; insanity; intellectual disability; and other psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-3gbsyc2	Effects of the Thoracoabdominal Rebalancing (TAR) Method in preterm infants	Not yet recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8729	Effects of the Thoracoabdominal Rebalancing (TAR) Method in preterm newborns: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Ciências da Saúde do Trairi - Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Preterm newborns of both sexes; with gestational age of less than 37 weeks; chronological age greater than 96 hours of life; receiving non-invasive ventilation (NIV), including Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (Bilevel); and with Silverman-Andersen Score (SAS) greater than 0	Newborns presenting hemodynamic instability (persistent alterations in heart rate or blood pressure above or below expected values or predefined alarm limits, and difficult-to-control arrhythmias); use of invasive mechanical ventilation (IMV); a clinical diagnosis of pneumothorax, pleural effusion, atelectasis, anemia, or structural and/or functional abnormalities of the chest wall, diaphragm, or upper airways; cardiovascular malformations; and diagnosed genetic syndromes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-59447vn	Effects of the treatment with the anti-inflamatory medication AP1189 on the lung involvement in COVID-19 patients with impaired breathing.	Recruitment completed	Intervention	2021-05-29	<NULL>	<NULL>	4699	Effects of the administration of AP1189, a pro resolutive pathways up regulator, on lung alterations of COVID-19 patients and impaired oxygenation	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-12-18	Universidade Federal de Minas Gerais	Hospital Eduardo de Menezes	https://ensaiosclinicos.gov.br/rg/RBR-59447vn	<NULL>	Male and female subjects, 18 to 85 years of age hospitalized with COVID-19 infection; Written informed consent; Confirmed COVID-19 by the presence of SARS-CoV-2 nucleic acid by polimerase chain reaction; Pregnancy is excluded or unlikely (reliable contraception/post-menopausal women).	Progress to death is imminent and unavoidable in the opinion of the investigator; Participating in other clinical trials (except in COVID-19 antiviral drug trials); Any condition that in the view of the screening physician suggests that the patient is unable to comply with study procedures; Subjects treated with immunosuppressive drugs; HIV infection; Pregnant women or breastfeeding mothers; Estimated glomerular filtration rate less than 30ml/min; Severe liver disfunction (Child-Pugh score C); Medical history of oral glucocorticoid treatment (Exception is COVID-19 dexamethasone treatment not exceeding 10mg/day).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:34
RBR-44xmsx	Effects of the ultrasound therapy on venous ulcer healing	not yet recruiting	Intervention	2012-05-07	<NULL>	<NULL>	137	Effects of ultrasonic waves application on morphometric parameters and metalloproteases gene expression in venous ulcers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-07	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-44xmsx	<NULL>	"Unhealed venous ulcer with at least eight weeks of duration
Ankle-brachial index equal or higher than 0,8
Without signs of venous ulcer infecction
Without previous diagnosis of connective tissue disease that may interfere in the healing process
Without contraindication for ultrasound use"	"Wound infecction
Exclusion by patient request"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-106frtzv	Effects of the use of a mobile application in women with complaints of stress urinary incontinence	Recruiting	Intervention	2022-10-10	<NULL>	<NULL>	5655	Effects of using a mobile application in female pelvic training in women complaining of stress urinary incontinence: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-106frtzv	<NULL>	Women with symptoms of stress urinary incontinence and/or mixed; aged over 18; literate; with preserved cognitive ability; with access to the internet; who have a mobile device with Android system; with understanding of the functioning of the application developed by the team of researchers.	Women who have symptoms of urinary incontinence only emergencies; pregnant women; puerperal women, with urinary tract infection; with presence of bone deformities and muscular dysfunctions; with neurological impairment that cause urinary incontinence; which underwent treatment and/or previous training of the pelvic floor muscles.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-2cyp7c	Effects of the use of colostrum as an oral therapy in very low birth weight preterm infants under the Unified Health System (SUS)	Not yet recruiting	Intervention	2018-12-17	<NULL>	<NULL>	2387	Colostrotherapy, nutrition, pondero-estatural growth and morbimortality of preterm infants of very low weight attended by the Unified Health System (SUS): intervention study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Estadual de Feira de Santana	Hospital Inácia Pinto dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-2cyp7c	<NULL>	Infants admitted to Neonatal Units; birth weight less than or equal to 1500g; less than or equal to 37 gestational weeks; zero diet by oral and enteral route or in total parenteral nutrition; clinically stable; until 24 hours of life.	Referring to the mother: maternal history of substance or drug abuse; presence of psychological disorder; multiple gestation from triplets; contraindications for breastfeeding (retroviruses and cytomegalovirus). Regarding the newborn: use of vasopressor medication greater than 10mcg / kg / min; needing for immediate surgical intervention; presence of syndromes and / or congenital malformations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-9j4thm	Effects of the use of non-invasive ventilation on breathing in children after cardiac surgery	Recruitment completed	Intervention	2013-09-16	<NULL>	<NULL>	248	Lung function in the postoperative period of cardiac surgery after use of continuous positive airway pressure (CPAP)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-24	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-9j4thm	<NULL>	"Children of both sexes aged 7-16 years, stable, who are undergoing cardiac surgery with median sternotomy during the study period.
Informed consent approved and signed by the heads."	"Children who present:
Hemodynamic instability (represented by fever, decrease or increase of 20 mmHg of the reference value of blood pressure or heart rate 20 bpm and severe hypoxemia);
Presence of contraindication to NIV
Respiratory distress (represented by increased respiratory rate (RR) according to age, increased work of breathing with the presence of runs intercostal, subcostal, and  or paradoxical pattern);
Children unfit to perform the technique (under sedation, decreased level of consciousness or who refuse to participate in the study)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-5ztk3mw	Effects of the use of Protein Supplements and Physical Exercise in elderly	Recruitment completed	Intervention	2024-03-05	<NULL>	<NULL>	6827	Effects of a Multimodal Intervention on health variables in institutionalized elderly with dietary control: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5ztk3mw	<NULL>	Belong to the institution; be at least 60 years old; able to stand up and move independently; have clinical clearance to carry out activities; follow the standardized meals offered by the institution; agree to sign the Free and Informed Consent Form	Participants who have any type of disease with a previous contraindication or impairment that limits anthropometric measurements and the regular practice of the proposed physical exercises; which are restricted to the bed; underwent surgery recently; had an amputation; have a confirmed medical diagnosis of chronic kidney disease; metabolically catabolic disease; severe neurological and muscle disorders; terminal illnesses; who are in palliative care; make use of nutritionally complete or protein supplements or drugs that affect protein metabolism; who do not consume animal foods; are allergic to milk; have recently experienced significant involuntary weight loss; use an assistive device or any artificial electrical implant; whose nutrition is provided by enteral route or who have contraindications for performing of exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-46hk7r	Effects of the Use of Rehabilitation Respiratory Instruments in Elderly with Voice Problems	Not yet recruiting	Intervention	2019-07-08	<NULL>	<NULL>	2806	Effects of the Use of Respiratory Instruments in the Rehabilitation of the Elderly with Dysphonia: A Randomized Clinical Trial	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-46hk7r	<NULL>	patients aged over 60 years; of both sexes; with otorhinolaryngological diagnosis of dysphonia; who agree to participate in the study through the signing of the informed consent form	Patients with neurological and / or psychological disorders; patients miss more than one therapy session; will be excluded; and / or patients who have undergone previous or simultaneous speech-language therapy will not participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-105h2gww	Effects of the use of virtual reality combined with a circuit-based coordinative approach on the development of children and adolescents with autism	Recruitment completed	Intervention	2026-02-20	<NULL>	<NULL>	8895	Effects of a 24-week intervention using virtual reality combined with a coordinative circuit approach on motor, cognitive, behavioral, and socioemotional performance in children and adolescents with level I autism spectrum disorder: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Federal do Vale do São Francisco	<NULL>	<NULL>	<NULL>	Children and adolescents of both sexes aged between ten and sixteen years who were literate; children with a confirmed diagnosis of autism spectrum disorder level one based on medical report or specialized assessment; availability to participate in all stages of the study including interventions and assessments; formal consent provided by parents or legal guardians through signing the informed consent form and assent form signed by the participants as well as authorization for the use of images signed by the legal guardian	Presence of severe or progressive neurological comorbidities such as uncontrolled epilepsy severe cerebral palsy or muscular dystrophies; medical contraindications to physical activity or exposure to virtual reality such as severe vestibular disorders; children with severe cognitive impairments that prevented understanding or execution of the proposed tasks; history of intolerance or severe discomfort related to the use of virtual reality headsets; absence from more than three consecutive sessions or total attendance lower than seventy percent of the proposed activities; occurrence of medical conditions or adverse health events during the study that prevented continuation of participation; persistent difficulty in understanding or performing the experimental procedures; identification of any previously unreported condition that contraindicated participation in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-7d3yxz3	Effects of the Vibrating Platform on Nerve Injury caused by chemotherapy	Not yet recruiting	Intervention	2023-11-10	<NULL>	<NULL>	6567	Effects of Whole Body Vibration in chemotherapy periphery induced Neuropathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-30	Hospital do Cancer II	Hospital do Cancer II	https://ensaiosclinicos.gov.br/rg/RBR-7d3yxz3	<NULL>	protocol of carboplatin associated with paclitaxel at a high dose; curative intent;  ovarian cancer; endometrial cancers	previous chemotherapy treatment; pre-existing neuropathy; metastases unstable bone fractures; cardiac pacemaker; lower limb surgeries in the last year; presence of metallic prostheses; deep venous thrombosis for less than 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-23kwzb	Effects of Therapeutic Currents in Health Subjects	Data analysis completed	Intervention	2013-10-30	<NULL>	<NULL>	263	Comparison of Sensorial Discomfort and Peak Torque During Neuromuscular Electric Stimulation With Medium and Low Frequency Currents	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-18	Univerdade Federal de São Carlos	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-23kwzb	<NULL>	Being female, healthy, physically active, aged between 18 and 30 years, body mass index (BMI) between 20 and 25 kg / m², with range of motion and knee function preserved, free from orthopedic diseases, pulmonary, cardiovascular, immune, and metabolic or chronic.	Age above 30 years. Male.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-2ys36cq	Effects of therapeutic hammock in hospitalized preterm newborns	Not yet recruiting	Intervention	2021-05-13	<NULL>	<NULL>	4648	Effects of positioning hammock on the neurodevelopment and clinical outputs of preterm infants: randomized controlled clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de Mato Grosso do Sul (UFMS)	Universidade Federal de Mato Grosso do Sul (UFMS)	https://ensaiosclinicos.gov.br/rg/RBR-2ys36cq	<NULL>	Preterm infants with corrected gestational age equal to 34 weeks; with more than 72 hours of postnatal life; hospitalized in a neonatal unit, with a stable clinical condition; with generalized movements of poor repertoire characteristic; without the need for invasive or noninvasive mechanical ventilation;	Those with congenital malformations, degree 3 and 4 periintraventricular hemorrhage, osteomyoarticular disorders, use of central nervous system depressants and use of invasive or noninvasive mechanical ventilation will not be included. The study will use analysis by intention to treat, that is, all participants included will be considered. However, only those whose parents request the removal of the infant from the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-6gx95tt	Effects of Therapeutic Taping on the lips of children with Trisomy 21	Not yet recruiting	Intervention	2025-12-16	<NULL>	<NULL>	8657	Therapeutic Taping effects on lip seal in children with Trisomy 21: comparison between Inelastic, Elastic, and Hyperelastic Tapes  a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Present Trisomy 21; be at least 2 years and at most 6 years old; not have complete lip sealing in the habitual position;  not be undergoing speech therapy for orofacial motor function.	Presence of other associated syndromes; craniofacial malformations; allergic reactions to the use of the bandage; skin lesions in the area where the bandage is applied.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-4244wxy	Effects of therapeutic treatment using tactile stimulation and joint movement, and skin-to-skin contact on the motor behavior of premature newborns: a non-inferiority randomized controlled clinical trial protocol.	Not yet recruiting	Intervention	2026-01-05	<NULL>	<NULL>	8694	Effect of Tactile-Kinesthetic Stimulation and the Kangaroo Method on the motor behavior of premature newborns: a non-inferiority randomized controlled clinical trial protocol	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-15	Empresa Brasileira de Serviços Hospitalares - EBSERH	<NULL>	<NULL>	<NULL>	Preterm newborns admitted to the Neonatal Intensive Care Unit of the Hospital da Mulher Mãe Luzia will be included in the study provided they are born with a gestational age between 28 and 36 weeks; with a corrected gestational age of 32 weeks or more; with an Apgar score greater than 6 at 1 and 5 minutes; of both sexes; older than 72 hours; with a body weight above 1.100g; presenting hemodynamic and clinical stability; receiving full enteral nutrition; via nasogastric or orogastric tube; or breastfeeding; in an incubator or crib; breathing room air or receiving support such as non invasive ventilation and oxygen supplementation	Preterm newborns will be excluded from the study if they present with congenital malformations; genetic syndromes; worsening of the underlying disease; hemodynamic and clinical instability; hypothermia; use of sedatives; thrombocytopenia with a value lower than 50.000; active hemorrhage; peri intraventricular hemorrhage; are on invasive mechanical ventilation; have a positive C Reactive Protein test; are in contact isolation or have experienced a cardiorespiratory arrest in the last 24 hours	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-4z5z3t	Effects of therapeutic ultrasound on the vascular response	Recruiting	Intervention	2014-04-28	<NULL>	<NULL>	286	Effects of therapeutic ultrasound of low intensity in endothelial function	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-4z5z3t	<NULL>	Literate volunteers. Aged between 18 and 40 years old. Body mass index (BMI: kg/m2) less than 30. Have no symptoms of musculoskeletal disorders. Not making use of medication (except contraceptives), smoking and alcohol. Have no previous diagnosis of rheumatic diseases, cardiovascular, metabolic, neurological, oncological, haematological and immunological. Absence of psychiatric or cognitive problems.	Volunteers who performed high-intensity physical activity 72 hours before evaluations; presence of inflammatory response measured by the ultrasensitive PCR &gt;3mg/dL, fibrinogen &lt;200 or &gt;400mg/dL, leukocytosis &gt;11,000 x103/mm3, body temperature less than 38ºC, consumer beverages containing caffeine or alcohol, arterial diameter between &lt;2.5mm and &gt;5mm and endothelial dysfunction assessed by FMD (&lt;8%).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-7dp6hs	Effects of three different strength training on mass and muscle strength.	Data analysis completed	Intervention	2016-03-11	<NULL>	<NULL>	747	Effects of isometric, isotonic or isokinetic training on mass and muscle strength.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7dp6hs	<NULL>	Age between 18 and 30; male; no history of knee or thigh injury in the past five years; had not undertaken any leg strength training during the previous six months.	Pain; swelling; inability to do exercises; asymptomatic orthopedic injuries or other pathology that  limits the realization of maximum torque with the lower limbs; female.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-5cxc2j	Effects of Time of Application of Massage on Recovery of Pain and Muscular Strength after Unusual Exercise in Buttock and Thigh Muscles	Recruitment completed	Intervention	2018-06-16	<NULL>	<NULL>	1906	Effects of Time of Application of Massage on Recovery of Muscle Damage in the Extension Muscles of the Hip and Knee	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-30	Universidade de Brasilia -Faculdade de Educação Fisica	Universidade de Brasilia -Faculdade de Educação Fisica	https://ensaiosclinicos.gov.br/rg/RBR-5cxc2j	<NULL>	Healthy young people; male; age between 18 and 30 years; six months of experience with resistance training; that answer &quot;no&quot; to all questions in the Physical Activity Readiness Questionnaire	with osteomioarticular involvement of lower limbs; diagnoses of cardiovascular pathologies; respiratory function; angina; users of medications that may affect muscle function	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-92q4qqw	Effects of Tissue Flossing and Neural Mobilization Techniques on Ankle of Adolescent Basketball Athletes	Data analysis completed	Intervention	2022-10-25	<NULL>	<NULL>	5680	The Effects of Tissue Flossing Techniques and Neural Mobilization on Ankle Range of Motion and Performance of Adolescent Basketball Athletes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-12	Universidade de Estado de Santa Catarina	Universidade de Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-92q4qqw	<NULL>	Male subjects; adolescent athletes of the Florianópolis basketball team; healthy; aged between 13 and 17 years; and with at least 6 hours of basketball training per week	Lower limb injury in the last 3 months; history of neurological or orthopedic disease that has affected lower limbs and makes them unable to perform the proposed tests; history of chronic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-3csjgb8	Effects of topical application of Silver-Nimesulide Complex in the Treatment of Patients with Squamous Cell Carcinoma of the Skin	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8845	Effects of topical application of Silver-Nimesulide Complex in the Treatment of Patients with Skin Squamous Cell Carcinoma: Phase I/II Study	<NULL>	1-2, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-12	Universidade Estadual de Campinas - UNICAMP	<NULL>	<NULL>	<NULL>	Men and women aged 18 years or older and under 90 years; confirmed diagnosis of cutaneous squamous cell carcinoma. Tumors with a minimum diameter of 1cm and superficially located in the skin. Surgical tumor resection previously scheduled; ensuring a minimum interval of 42 days between the initiation of treatment with the silver–nimesulide biocurative (CB-Ag-NMS) and the surgical procedure. Signed or recorded Informed Consent Form (ICF)	Participants with lesions located on the face. Lesions near superficial blood vessels. Ulcerated tumor. Dermatological comorbidities that may interfere with clinical evaluation. Known hypersensitivity to silver; nimesulide or adhesive materials. Pregnant or breastfeeding women. Immunosuppressed individuals. Participants who do not have a previously scheduled tumor resection surgery at the Institution	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-7vbw5gd	Effects of Traditional Chinese Acupuncture and Laser Acupuncture on cervical pain non-specific chronic	Recruiting	Intervention	2021-06-08	<NULL>	<NULL>	5480	Effects of Traditional Chinese Acupuncture and Laser Acupuncture on cervical pain non-specific chronic: randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-10	Universidade Federal de São Carlos (UFSCar).	Universidade Federal de São Carlos (UFSCar).	https://ensaiosclinicos.gov.br/rg/RBR-7vbw5gd	<NULL>	Volunteers of both sexes aged between 18 and 60 years old and neck pain of at least 3 months; obtain a score greater than or equal to 3 points for pain intensity on the Numerical Pain Scale; have completed elementary school, consent to random allocation.	Volunteers with spinal injuries; spondylolisthesis; spinal canal stenosis; ankylosing spondylitis; signs of radiculopathy; cancer; acute infections; hemorrhagic diseases; rheumatological diseases; systemic inflammatory diseases; rheumatoid arthritis; in conditions of pregnancy, puerperium and breastfeeding. Individuals who have started or undergone another treatment in the past 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-77h8fhf	Effects of Traditional Resistance Training and Co-Contraction on the strength and hypertrophy	Recruiting	Intervention	2023-12-01	<NULL>	<NULL>	6626	Effects of Traditional Resistance Training and Co-Contraction on the strength and hypertrophy of elbow flexor and extensor muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-77h8fhf	<NULL>	Adults aged between 18 and 35 years of both sexes; without musculoskeletal injuries in the last 12 months; and with no medical contraindications for physical exercise	Inability to train at the proposed times; a history of musculoskeletal injury in the upper limbs within the last 12 months; and the presence of any health issues that may interfere with the execution of the proposed exercises and assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-5tcczr9	Effects of training consisting of different exercise modalities on functional capacity, quality of life and mental health in institutionalized elderly coronavirus survivors	Not yet recruiting	Intervention	2022-03-03	<NULL>	<NULL>	5256	Effects of multicomponent training on functional capacity, quality of life and mental health in institutionalized elderly survivors of Covid-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-15	Universidade Federal do Rio Grande do Sul- UFRGS	Centro Universitário da Serra Gaúcha- FSG	https://ensaiosclinicos.gov.br/rg/RBR-5tcczr9	<NULL>	Institutionalized individuals; age equal to or greater than 60 years; both genders; who had Covid-19 infection	Neurological disease; cardiovascular and respiratory changes; presence of joint or musculoskeletal injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-66yr4x	Effects of training in lower limb exercise in patients after cardiac surgery	Not yet recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1816	Effects of training cycle ergometer in patients after cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-66yr4x	<NULL>	cardiac post-surgical patients hospitalized in the ICU; of both sexes; aged 18 years or older; level of light sedation; without sedation or who are level-2 to zero by the sedation scale of Richmond Agitation Sedation; vasoactive and / or inotropic drugs less than 0.5 mg / kg / min; mean arterial pressure between 60 and 100 mmHg; heart rate between 60 and 120; muscle strength 3 by the manual muscle strength test Medical Research Council (MRC); functional independence prior to hospitalization. And the ventilatory parameters used are: FiO2 bigger than 60%; PaO2 bigger than 70mmHg; PEEP less than 8; SpO2 bigger than 90%; f less than 35irpm	Those who give up the research; evolve to death or need to be reopened surgically	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-4j428f	Effects of training in the pool in balance in elderly individuals	Recruitment completed	Intervention	2015-03-17	<NULL>	<NULL>	420	Hydrotherapy in balance in elderly individuals	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-01	Universidade Federal da Paraíba	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-4j428f	<NULL>	Elderly individuals (between 60 and 90 years) from both sexes,  sedentary, independents in the gait and daily activities.	Show dysfunction in the neurological and cardiovascular systems, cognitive alterations, diagnosis of vertigo, hearing problems or urinary infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-573pcm	Effects of training the muscles of inspiration and training the muscles of the center of the body in professional athletes	Data analysis completed	Intervention	2018-06-07	<NULL>	<NULL>	1880	"Effects of inspiratory muscle training and
core training in professional athletes"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-10	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-573pcm	<NULL>	Males; Being an athlete at competitive level for at least one year; Having aged 18 to 35 years	Use of medications that interfere on autonomic control;respiratory diseases;cardiovascular diseases; smoking;sports injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-5sgsxb	Effects of training the muscles of inspiration associated with the foundation workout of the wheelchair basketball tray on the strength of the breathing muscles and physical performance of high performance athletes	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1928	Effects of inspiratory muscle training associated with the training of the wheelchair basketball tray foundation on the aerobic physical performance, cardiopulmonary and metabolic variables of high-performance athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5sgsxb	<NULL>	practice wheelchair basketball at a competitive level for more than five months; train at least three times a week; compete in official championships of the sport	smoking; presence of cardiovascular respiratory and motor alterations that made impossible the execution of evaluation or intervention protocols; inability to understand the techniques for implementing the evaluation and intervention protocols	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-7h6b8mg	Effects of training with Immersive Virtual Games compared to Stationary Cycling on tremor, upper limb function and cognition in people with Parkinson&apos;s Disease: randomized clinical trial	Recruiting	Intervention	2023-12-11	<NULL>	<NULL>	6644	Effects of Immersive Virtual Reality training compared with Stationary Cycling on tremor, upper limb function and cognition in people with Parkinson&apos;s Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Faculdade de Ceilândia da Universidade de Brasília	Associação de Centro de Treinamento de Educação Física Especial	https://ensaiosclinicos.gov.br/rg/RBR-7h6b8mg	<NULL>	Individuals of both genders; diagnosed with PD by a neurologist according to the MDS-PD criteria and selected by a physical therapist for study eligibility; classified in stages I to III according to the Hoehn &amp; Yahr classification; age between 50 and 85 years; presence of classic parkinsonian tremor type 1, according to the consensus statement of the Movement Disorders Society; Minimum score on the Mini Mental State Examination according to schooling median scores; normal or corrected visual and hearing acuity; Minimum schooling of 4 years of formal study; normal or corrected visual and hearing acuity; a minimum of 4 years of formal schooling	Individuals with other associated neurological diseases or conditions that prevent participation in the training; have previous experience with the Quest 2® system; be attending another specialized rehabilitation program; have a score higher than 5 on the Geriatric Depression Scale - GDS - 15 items; have undergone implantation of deep brain stimulation electrodes; present visible dyskinesia in upper limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-78b6zky	Effects of Training with Solo and Apparatus Pilates on improving the Cardiorespiratory and Metabolic Systems of hypertensive patients using medicines.	Recruitment completed	Intervention	2021-09-09	<NULL>	<NULL>	4873	Chronic effects of the Pilates Method on cardiorespiratory and metabolic responses in controlled hypertensive women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-03	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-78b6zky	<NULL>	Be controlled hypertensive; regardless of the class of medication used and the combination of two or more medications; be between 30 and 59 years of age; be sedentary for at least six months; have a body mass index of up to 30 kilos per square meter; not using contraceptives or under hormonal replacement; having medical clearance to practice physical exercise; not having osteomioarticular disease that could compromise the partial or total performance of the proposed exercises; not having any other disease that could compromise the cardiovascular; respiratory or metabolic to exercise; do not have diabetes mellitus; do not smoke or drink alcohol; do not have damage to a target organ; such as nephropathy; heart disease; etc. and accept to be a project volunteer. Only women with BP will be included in the study. Controlled; that is; who are undergoing drug treatment of any class. All volunteers included in the study signed an informed consent form.	Women who during the experimental period 4 months; have changes in drug treatment as class; dose; drug interaction and those who; at the end of 16 weeks of physical training; have a frequency below 75% or who have had two or more consecutive absences in training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-7p2jfnz	Effects of training with videogame on tremor, arm function and cognition in patients with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2021-06-01	<NULL>	<NULL>	4712	Effects of training with Nintendo Wii on tremor, functionality of upper members and cognition in patients with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-05	Faculdade de Ceilândia - Universidade de Brasília	Faculdade de Ceilândia - Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7p2jfnz	<NULL>	The participation of the study subjects will be conditioned to the following inclusion criteria: age between 50 and 85 years; female and male sex; presence of classic type 1 parkinsonian tremor, according to the consensus statement of the Movement Disorders Society (Deuschl et al., 1993), minimum score of 24 on the Mini Mental State Examination - MEEM; Normal or corrected visual and auditory acuity, allowing interaction with the Nintendo Wii TM system; Score of 1 to 3 on the Hoehn and Yahr Scale; Minimum education of 4 years of formal study.	After selecting all participants who meet the inclusion criteria, those who: Have other associated neurological diseases or conditions that prevent participation in training will be excluded; Have previous experience with the Nintendo Wii TM system; Are attending another specialized rehabilitation program; Score greater than 5 on the Geriatric Depression Scale - GDS - 15 items	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-8ym65t	Effects of training withi an arm ergometer adapted on the functionality and exercise capacity of COPD patients	Recruiting	Intervention	2018-10-05	<NULL>	<NULL>	2265	Effects of training withi an arm cycle ergometer adapted in functional and exercise capacity in patientes with COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8ym65t	<NULL>	"Diagnosis of COPD based on clinical and spirometric criteria;
Gold classification 2 or 3 (GOLD, 2018);
Non-smokers or former smokers;
Clinically stable in the month prior to the beginning of the protocol."	"Individuals with musculoskeletal diseases that preclude participation in the protocol such as arthroses, tendinitis and upper limb (UL);
Neurological diseases with involvement of UL;
Individuals who can not complete any of the proposed activities;
Exacerbation during the collection period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-5stwwm	Effects of Tranexamic Acid on surgical tretament for severe nasal bleeding	Recruiting	Intervention	2015-04-17	<NULL>	<NULL>	452	Effects of intravenous Tranexamic Acid on surgical arterial ligations for severe epistaxis	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2013-10-01	Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - Universidade Federal de São Paulo (UNIFESP)	Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-5stwwm	<NULL>	Patients with severe spontaneous epistaxis; indication of surgical treatment; both genders; 18-90 years-old.	Formal contraindications to the use of tranexamic acid; acute vaso-occlusive disease; active intravascular coagulation; hypersensitivity to the components of the formula; known coagulopathy; use of oral anticoagulants; altered coagulation tests; use of the drug on the 7 days before inclusion in the study; patient&apos;s refusal to participate in the study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-2kg65g7	Effects of Transcranial Direct Current Stimulation at Different Intensities Associated or Not with Binaural Frequencies on Oxygen Saturation and Reaction Time: Randomized Controlled Study	Not yet recruiting	Intervention	2024-02-23	<NULL>	<NULL>	6801	Effects of Transcranial Direct Current Stimulation at different Intensities associated or not with Binaural Frequencies on Cerebral Hemodynamics and Reaction Time: Randomized Controlled Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Maria de Cassia Gomes Souza Macedo	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2kg65g7	<NULL>	Young adults aged between 18 and 30; with normal hearing; without a history of neuropsychiatric disorders; without the use of psychoactive substances	Participants with metallic materials implanted in or near the head; with pacemakers or cardiac stents; with active devices where interaction with the electrical field may interfere with their operation; individuals with eczema on the head	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-6brhz73	Effects of Transcranial Electrical Stimulation associated with Electrical Stimulation in the leg on gait recovery in individuals after chronic Stroke: a randomized controlled clinical trial	Data analysis completed	Intervention	2023-08-07	<NULL>	<NULL>	6313	Effects of Transcranial Direct Current Stimulation associated with Peripheral Electrical Stimulation on the functional recovery of individuals after chronic Stroke: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-05	Universidade Federal do Ceará	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6brhz73	<NULL>	Volunteer of both sexes; single case of stroke for at least 6 months; ischemic or hemorrhagic brain injury; age above 18 years; presence of motor sequelae in one hemibody; ability to walk approximately 10 meters on the ground with or without a walking aid; minimum score of 24 points (for individuals with schooling) or 18 points (for individuals with no schooling) on ​​the mini-mental state exam	Epilepsy episodes; undiagnosed headache; intracranial metal implant; cardiac pacemaker; pregnancy (or suspected); depression; other clinical conditions of orthopedic, neurological or cardiac origin that do not allow participation in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-8pdy4q8	Effects of Transcranial Photobiomodulation Therapy in the rehabilitation of individuals up to three months after Stroke: a randomized clinical trial	Recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7861	Effects of Transcranial Photobiomodulation Therapy on the rehabilitation of individuals after Stroke: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-30	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8pdy4q8	<NULL>	Participants of both sexes; age between eighteen and fifty-nine years; up to three months from the episode of unilateral ischemic stroke; not neglecting paretic limbs; hemodynamically stable; without peripheral neuritis; able to understand and follow simple verbal instructions	Inability to understand questionnaires; hypersensitivity to light; oncological pathologies; infectious pathologies; post-surgical spinal procedures; rheumatic diseases; renal diseases; hepatic diseases; untreated gastrointestinal diseases; untreated psychiatric diseases; immunosuppression; pregnant women; lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-52y3zgd	Effects of Transcranial Stimulation and balance training in individuals with Parkinson: a randomized clinical trial	Recruitment completed	Intervention	2022-07-11	<NULL>	<NULL>	6300	Effects of Transcranial Direct Current Stimulation (tDCS) associated with balance training in individuals with Parkinson&apos;s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal do Amazonas	Hospital Universitário Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-52y3zgd	<NULL>	Individuals of both sexes, regardless of age, with a clinical diagnosis of PD, rated 3 or 4 on the Hoehn &amp; Yahr scale, and who agreed to participate in the study by giving consent, were included.	Individuals with other neurological disorders other than PD and with cognitive deficits that prevented them from performing the assessments were not included, and individuals with scores lower than 8 on the 10 Point Cognitive Screener (10-CS) were not included. Individuals who were undergoing Physiotherapeutic care, who had undergone Physiotherapy for less than 1 month, or who had a Deep Brain Stimulation device (DBS) were also not included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-6xtvg5w	Effects of transcutaneous auricular vagus nerve stimulation in individuals with Parkinson&apos;s disease - a double-blind randomized controlled clinical trial	Recruiting	Intervention	2024-01-08	<NULL>	<NULL>	6711	Effects of non-invasive transcutaneous auricular vagus nerve electrical stimulation in individuals with Parkinson&apos;s disease - A double-blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-23	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6xtvg5w	<NULL>	Individuals of both sexes; aged between 40-80 years, with a diagnosis confirmed by a neurologist of Parkinson&apos;s disease present in stages 1 to 3 of the Hoehn and Yahr scale; who have motor and cognitive complaints related to the Unified Parkinson&apos;s Disease Rating Scale (UPDRS) and who have been on stable Parkinson Disease medication for at least 30 days	Individuals with characteristics of other types of parkinsonism; having other health conditions such as musculoskeletal problems, decompensated respiratory or cardiovascular problems, uncontrolled diabetes, uncontrolled systemic arterial hypertension, psychiatric conditions such as dementia diagnosed by a psychiatrist, contraindications for the intervention (implanted cardiac or cranial electronic medical devices, cochlear implant, pacemaker) or conditions in which the principal investigator assesses as not indicated for participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-32ds8h	Effects of treadmill lateral walking in individuals with Parkinson disease	Recruiting	Intervention	2020-01-24	<NULL>	<NULL>	3396	Immediate effects of lateral walking treadmill training in individuals with Parkinson disease: randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-22	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-32ds8h	<NULL>	Be between stages 2 and 3 of the Hoehn and Yahr Scale; make regular use of antiparkinsonian medication; without any type of orthotic or gait aid, independently (scores 3 to 5 of the Functional Ambulatory Category - FAC), by at least 10 meters; do not have severe cognitive deficits that impede the comprehension of simple verbal instructions (detectable through the Montreal Cognitive Assessment (MoCA) scale); and have not undergone stereotaxic surgery.	Present blood pressure (BP) with systemic and diastolic values above 200 mmHg and 110 mmHg, respectively, before or during training; heart rate (HR) above the values shown, calculated by the formula [HRsub = 0.75x (220-age)]; present other types of neurological, musculoskeletal, cardiovascular, respiratory, visual and / or hearing disorders that make treadmill gait training impossible and an application of the protocol; any change in dosage and / or type of antiparkinsonian drug; and presence of pain, dyspnea and / or severe muscle fatigue that prevents the inheritance of the training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-78qtwy	Effects of treadmill physical exercise in women with polycystic ovaries	Recruiting	Intervention	2016-03-07	<NULL>	<NULL>	739	Effects of continuos and interval aerobic physical training  in women with polycystic ovary syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-11	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-78qtwy	<NULL>	Volunteers with PCOS between 18 to 39 years old; body mass Index between 18 and 39.9 kg/m2 (normal overweight and obesity grades I and II); Do not practice regular physical activity.	Presence of systemic disease that contraindicate to physical activity; presence of disabling musculo-skeletal disorders; use of drugs that interfere with the hypothalamic-pituitary-ovarian-axis and hormonal contraceptives; smoking, pregnant and volunteers who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-6qs4tb	Effects of treadmill training with partial body weight support and the one physical therapy method on gait of patients with stroke	data analysis completed	Intervention	2011-11-09	<NULL>	<NULL>	34	Analysis of the effectiveness of treadmill training with partial body weight support and the Proprioceptive Neuromuscular Facilitation method on the hemiparetic gait due to stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Ana Raquel Rodrigues Lindquist	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6qs4tb	<NULL>	The sample was composed of men and women, aged between 40 and 70 years, with chronic hemiparesis following unilateral and non-recurring stroke, with spasticity classified between levels 0 and 2 on the Modified Ashworth Scale of muscle spasticity for the lower limb affected; ambulatory capacity classified between levels 3 and 5 on the Functional Ambulatory Category; minimum sequel time of 6 months; absence of clinical signs of cardiac alterations (New York Heart Association, degree I); absence of other orthopedic or neurological impairment that caused gait alterations; ability to walk 10m without assistive devices; not using orthotics on the paretic lower limb; and capacity to obey simple verbal commands.	Exclusion criteria were individuals whose heart rate exceeded 75% of age-adjusted maximum heart rate and those who had fear of falling while walking on the treadmill.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-89x588	Effects of Treadmill walking on quality of life and 6-minute walk test of institutionalized elderly	Recruiting	Intervention	2018-02-02	<NULL>	<NULL>	1622	"Effects of a Treadmill program on quality of
life and functional capacity of
institutionalized elderly"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-07	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-89x588	<NULL>	Elderly institutionalized residents of the city of Marília-SP; of both sexes; aged 60 years or older; with functional impairment categories (CDF) greater than or equal to 2; without cognitive deficit in the Mental State Mini Exam according to the years of schooling (BRUCKI et al., 2003)	Individuals who refuse to sign the consent form; with untreated neurological or cardiorespiratory pathologies and / or who limit the ability to walk on the treadmill; with visual or auditory deficits incapacitating to conduct the research; and the elderly who interrupt in any Stages of intervention or evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-662hn2	Effects of treatment by Telecommunication Services on the pain, functionality and amount of fatty tissue between muscles of patients with knee Arthrosis	Recruiting	Intervention	2019-07-22	<NULL>	<NULL>	4643	Effects of telereabilitation on pain, physical function, and intermuscular adipose tissue concentration in patients with knee Osteoarthritis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-22	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-662hn2	<NULL>	Participants of both sexes, aged 40 years or older and diagnosed radiographically and clinically with unilateral or bilateral knee OA, grade II or III, according to the criteria of Kellgren and Lawrence, 1957, and American College of Rheumatology. For participants who present bilateral knee OA, the most symptomatic side will be used for evaluation.	Individuals who undergo physical therapy or any type of physical activity regularly up to 6 months prior to the start of the evaluation of this study and individuals who have had previous knee surgery, use of infiltration of corticosteroids in the knees, and  have history of lower limb trauma within 30 days prior to evaluation. Also excluded are individuals who use prosthesis partial or total of hip or knee, and use of chondroprotectors, or are carriers of rheumatic diseases, and cognitive deficit that compromises the understanding of the tests. Individuals with a body mass index, BMI, greater than 30 kg by m2, uncontrolled heart disease, a history of severe muscle injuries above grade I, motor deficits due to neuromuscular disease or any other medical restriction that makes it impossible to participate in this study, will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-3ddg2k	Effects of treatment of painful shoulder muscle nodules on shoulder pain, mobility, and muscle function in individuals with shoulder pain	Data analysis completed	Intervention	2018-07-10	<NULL>	<NULL>	2839	Effects of ischemic compression therapy at myofascial trigger points on pain, mobility, and muscle function of the shoulder complex in individuals with shoulder pain	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3ddg2k	<NULL>	Presence of at least one active or latent PGM, on the symptomatic side, in one of the following muscles: upper trapezius, lower trapezius, supraspinatus, infraspinatus, minor pectoris and middle deltoid.The subjects should have a history of unilateral shoulder pain, lasting more than one week, located in the proximal anterolateral region of the shoulder, or in the C5 or C6 dermatome region; Least three of the special tests for SIS diagnosis considered positive: Neer test; Hawkins&apos; test; Jobe&apos;s test; Painful arch test; External rotation resistance test; Gerber test and Speed biceps test.	Signs and symptoms of bilateral SIS;Primary adhesive capsulitis; Reproduction of shoulder pain which radiates to the entire upper limb; Numbness or tingling in the upper limb or any other symptom in the upper limb during foraminal compression test; History of symptom onset due to glenohumeral displacement or subluxation; Joint deformation in the glenoid or humeral head; Or fracture of the clavicle, scapula or humerus;History of surgical stabilization or repair of the rotator cuff;Groove test or positive seizure test;Signs of complete rupture of the rotator cuff, as evidenced by the positive fall test; Systemic disease involving joints such as rheumatoid arthritis and systemic lupus erythematosus and fibromyalgia, which involves myofascial tissue;Neurological pathologies; Use of analgesics and muscle relaxants 72 hours before the evaluation;Use of corticoid injection 3 months prior to evaluation;Body mass index (BMI)&gt; 28kg /m2;Symptoms of depression, with score 13 in the Beck Depression Inventory;Be there for a period of 1 month without participating in any program of physiotherapeutic treatment, stretching, strengthening or specific resistance exercises for the upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-9dkn9ry	Effects of treatment with FOPCON in patients with Fibrodysplasia Ossificans Progressiva	Recruitment completed	Intervention	2023-08-07	<NULL>	<NULL>	6311	Clinical, biochemical and molecular aspects in patients with Fibrodysplasia Ossificans Progressiva before and after treatment with ascorbic acid, propranolol, hesperidine and epigallocatechin	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal de Mato Grosso do Sul	Instituto de Assistência e Pesquisa em Educação e Saúde - IAPES	https://ensaiosclinicos.gov.br/rg/RBR-9dkn9ry	<NULL>	Individuals with clinical signs of classic FOP (and possible variants); both sexes; any age; term of consent/signed assent	Link to other experimental research proposals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-7nzwkpg	Effects of treatment with oral anticoagulant associated with antibiotic therapy in Covid-19	Recruiting	Intervention	2021-01-06	<NULL>	<NULL>	5162	Effects of treatment with oral anticoagulant associated with antibiotic therapy on clinical, immunological parameters, hospitalization and mortality in patients with suspected Covid-19 infection and positive d-dimer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-30	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7nzwkpg	<NULL>	Patients over 18 years of age; clinical suspicion of Covid-19; oxygen saturation between 93% and 97%; at least one more symptom according to the Ministry of Health criteria including tiredness or shortness of breath; fever and chills reported; cough and loss of smell or taste; positive result for the D-dimer test	Patients with active infectious diseases; immunosuppressive diseases or active cancer; pregnant or lactating women; known renal failure; current use of anticoagulants; contraindication to the use of Edoxaban or Moxifloxacin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-8k44cz5	Effects of treatment with stimulation at specific points of the feet combined with physical exercise on gait in individuals with Parkinson&apos;s Disease	Recruitment completed	Intervention	2025-11-11	<NULL>	<NULL>	8527	Acute effect of automated mechanical peripheral stimulation combined with physical exercise on locomotion in individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-19	Universidade Estadual Paulista Júlio de Mesquita Filho	<NULL>	<NULL>	<NULL>	Diagnosis of idiopathic Parkinson&apos;s Disease as determined by the London Brain Bank Criteria; mild-moderate disease stage (Hoehn &amp;Yahr I-III); age above 60 years; ability to walk independently; no changes in medication regimen in the past six months	History of diabetic polyneuropathy; cognitive decline (Montreal Cognitive Assessment score ≤ 26 points); had undergone Deep Brain Stimulation surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:48
RBR-53qz7zn	Effects of trigger point compression and Cupping Therapy on individuals with neck Pain	Recruiting	Intervention	2024-06-04	<NULL>	<NULL>	7045	Effects of Manual Ischemic Compression and Cupping Therapy on individuals with neck Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de Santa Catarina	Laboratório de Avaliação e Reabilitação do Aparelho Locomotor	https://ensaiosclinicos.gov.br/rg/RBR-53qz7zn	<NULL>	Women; age between 18 and 40 years; body mass index (BMI) ≤ 35 kg/m²; presence of an active trigger point in the descending trapezius; acute neck pain with onset within 3 months; pain level ≥ 3 on the numerical pain rating scale (NPRS) on the day of the assessment	Any self-reported injury or limitation in the cervical region or shoulder; concomitant treatment for neck or shoulder pain; use of analgesics, anti-inflammatories or muscle relaxants within 48 hours prior to the assessment; any contraindication to cupping; pre-menstrual syndrome (PMS), period of menstruation and pregnancy; signs or history of rheumatological or neuropathic diseases, endocrine or autoimmune disorders and spinal surgery; any event that does not allow the subject to participate throughout the research period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-6wy5y4t	Effects of Trunk-Specific Exercise on Pain, Inflammation, and Hormonal Release in Women with Back Pain	Data analysis completed	Intervention	2021-12-13	<NULL>	<NULL>	5099	Acute neuroimunoendocrin effects of high and low volume core training in women with unspecific chronic low back pain: a crossover study	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6wy5y4t	<NULL>	Women will be included in the research with a clinical diagnosis of nonspecific chronic low back pain, between 18 and 40 years old, who have complained of low back pain for more than 3 months, with a pain level between 3 and 6 on the Numeric Pain Rating Scale (NRS) (COSTA, et al. 2008). The volunteers will need to present a body mass index (BMI &lt;30 kg/cm2); not being pregnant; not having given birth for less than three months; not having undergone any surgery on the spine; not having performed any type of exercise in the last three months; not being undergoing any type of pain treatment; and without the use of analgesic, anti-inflammatory, opioid or immunosuppressive medication.	Participants who miss one of the days of the tests or who have any psychiatric or cognitive impairment, hearing, visual or communication disorders that make it impossible to carry out the protocol will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-6d73tn	Effects of two adhesive tapes for fixing the urinary catheter	Recruiting	Intervention	2020-09-18	<NULL>	<NULL>	4256	MARSI Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-08	Universidade Federal de Mato Grosso do Sul	Hospital Universitário Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-6d73tn	<NULL>	Patients 18 years of age or older; using IUC; and absence of Medical Adhesive Related Skin Injury (MARSI)	Patients with absence of bilateral femoral pulse; cutaneous abnormalities in the regions of fixation of the indwelling urinary catheter (spots, scars, warts, lesions, irritations or abrasions); acute systemic dermatological diseases (such as Stevens-Johnson syndrome and toxical epidermal necrolysis); congenital dermatological diseases and those who express an express wish to discontinue participation or non-application of the tape for more than 24 hours uninterrupted	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-8rz4yq	Effects of two bodybuilding programs in health and physical performance	Recruitment completed	Intervention	2015-02-23	<NULL>	<NULL>	398	Effects of two periodized resisted training programs on markers of metabolic syndrome and functional fitness	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Departamento de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-8rz4yq	<NULL>	Age between 40 and 60 years; have metabolic syndrome; no regular physical activity or strength training in the last 6 months.	Use of drugs or medicines that are not related to the metabolic syndrome factors; amenorrhea; presence of inflammation or infection; musculotendinous or osteoarticular injuries in the upper limbs, lower limbs or column; respiratory diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-98b36rc	Effects of two different exercise protocols for treating women with jaw pain	Recruiting	Intervention	2022-03-15	<NULL>	<NULL>	5284	Effects of two different exercise protocols for treating women with temporomandibular disorders: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-98b36rc	<NULL>	Women with TMD diagnosed by the DC/TMD criterea; Orofacial pain intensity higher than 3 points (NPRS); Onset of pain greater than 3 months;	Participants who start a new treatment in addition to the proposed one and participants who show signs and/or symptoms of exercise intolerance; pregnant women, or women undergoing hormone replacement; women who underwent some type of non-pharmacological treatment for TMD and neck pain in the last 6 months; irregular use of an interocclusal splint in the past 6 months; other causes of orofacial pain such as caries, periodontal diseases; or who had a history of head trauma that is related to the etiology of orofacial pain confounding the diagnosis of TMD; women with intracranial disorders; history of surgery in the orofacial or cervical region; continuous use of medications in the last 3 months such as muscle relaxants, anticonvulsants, beta blockers, bronchodilators, antidepressants and anxiolytics; female smokers or former smokers with less than 1 year of interruption; who have severe arrhythmias; obese (BMI&gt;30km/m2); participants who present cardiovascular, respiratory, neurological and orthopedic diseases, which prevent the performance of physical exercise, or whose exacerbation is induced by physical exertion; neuropathies, fibromyalgia and rheumatic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-5xs4wzx	Effects of two different nutritional strategies in adults with prolonged symptoms of Covid-19	Not yet recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8725	Effects of two different nutritional strategies in adults with prolonged symptoms of Covid - 19	<NULL>	n/a, n/a, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-26	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Adults who meet the established inclusion criteria will be recruited, including age between 40 and 59 years; presence of overweight or obesity according to the cutoff points established by the World Health Organization in 2005; signed informed consent form; availability to participate in multiprofessional interventions twice a week in the morning period for 12 weeks; and attendance at the initial project assessments	As exclusion criteria participation in sports activities outside the project; failure to achieve at least 75 percent attendance in the offered interventions; absence for more than two consecutive sessions in the program; failure to follow the proposed recommendations such as adherence to the diet; presence of orthopedic cardiovascular conditions or cognitive impairments that prevent the practice of physical exercise; following another type of non recommended restrictive diet; use of psychotropic medications or appetite suppressants; and occurrence of any accident that makes participation in the practical interventions impossible	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-62kr6f	Effects of two different physical training associated with diet on health in obese	Recruitment completed	Intervention	2017-09-06	<NULL>	<NULL>	2277	Effects of high intensity interval training and moderate continuous associated with diet on cardiometabolic parameters in obese	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-12	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-62kr6f	<NULL>	Volunteers should not be engaged in exercise programs; body mass index between 30 and 39,9; body mass stability in the last six months.	Current smokers; body mass index greater than 40; have a clinical diagnosis of chronic non-communicable diseases; pregnant; postpartum; breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-8yb47v	Effects of two exercise programs on pain, functionality and running pattern in runners with anterior knee pain	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3976	Effects of two gait retraining programs on pain, functionality and lower limb kinematics in runners with patellofemoral pain: a randomized clinical trial with 6-months follow-up.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8yb47v	<NULL>	Rearfoot runners with step rate under 170 steps/minute, age between 18 and 45 years, minimum pain levels of 3/10 on the Visual Analogue Scale (VAS) during running and one task among squatting, climbing, and descending steps, kneeling, and extending the knee with resistance, and being comfortable running at a speed of 10-12 km/hour.	Other diseases in the lower limbs, history of surgery in the lower limbs in the last year, and not showing interest to adhere to a strict running retraining protocol for 2 weeks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-6cmf4j	Effects of two exercise protocols on pain, functional mobility and quality of life in individuals with hip osteoarthritis	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4310	Effects of combined versus aerobic exercise on pain, functional mobility and quality of life in individuals with hip osteoarthritis: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-10	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6cmf4j	<NULL>	"individuals aged at least 30 years; both sexes; with clinical diagnosis of osteoarthritis of
hip uni or bilateral; sedentary in the last 6 months"	"individuals with hip and / or knee arthroplasty, whether total or partial;
rheumatoid arthritis, neurological, cardiovascular and / or pulmonary diseases that can compromise
execution of the exercise protocol. Discontinuation criteria: discontinuation of
individuals who did not attend two or more sessions and / or those who gave up
participate in the study during the intervention."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-9sy4bz	Effects of two Heating Protocols on Surface Temperature and Functional Performance in Amateur and Recreational Soccer players.	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4175	Evaluation of the Acute Effects of Two Heating Protocols on Surface Temperature and Functional Performance of Lower Limbs of Amateur and Recreational Soccer players.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-14	Fapemig	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-9sy4bz	<NULL>	Male players; Age between 18 and 30 years; Trainings up to 3 times a week; Participating in championships; Without lower limb dominance restriction; Without restriction of operating position.	"History of kidney problems; Physiotherapy in the last two days; Consume any diuretic or antipyretic and any food supplement: such as creatine that may interfere with water or homeostasis body temperature in the last two weeks;
Smoker; Burns on the skin; With topical treatments creams, ointments or lotions; Pain symptoms in any region of the body; Fever in the last seven days; Sleep disorders; Comply with the criteria for musculoskeletal injuries of the Research and Medical Evaluation Center of the International Football Federation;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-98mbrw	EFFECTS OF TWO ONLINE INTERVENTION MODELS ON PHYSICAL AND QUALITY OF LIFE PARAMETERS OF OVERWEIGHT OR OBESE WOMEN	Recruitment completed	Intervention	2020-07-06	<NULL>	<NULL>	4646	EFEITOS DE DOIS MODELOS DE INTERVENÇÃO ON-LINE EM PARÂMETROS FÍSICOS E DE QUALIDADE DE VIDA DE MULHERES COM EXCESSO DE PESO OU OBESIDADE	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Unicesumar	Universidade Unicesumar	https://ensaiosclinicos.gov.br/rg/RBR-98mbrw	<NULL>	Class I overweight or obese women; be between 40 and 59 years of age; have availability to participate in the interventions; present medical clearance for physical activity; be insufficiently active according to the International Physical Activity Questionnaire (IPAQ)	Presence of musculoskeletal limitations that can limit the practice of physical exercises; use of psychotropic drugs or glucocorticoids; having suffered an acute myocardial infarction in the last 6 months; be engaged in some diet programming, such as: low-carb, low-fat, hypocaloric, among others.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-8tpphf	Effects of two physical exercise programs on the behavior of physical function and heart and analysis of inflammatory markers and respiratory gases in healthy subjects	Data analysis completed	Intervention	2015-04-13	<NULL>	<NULL>	443	Effects of two physical exercise programs on issues related to the physical, cardiovascular, biological and metabolic functions in healthy subjects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Faculdade de Ciências e Tecnologia  - Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Ciências e Tecnologia  - Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-8tpphf	<NULL>	Female subjects; apparently healthy; classified as inactive by the Baecke questionnaire for assessing habitual physical activity; age between 18 and 30 years.	"Being a smoker; making consumption of alcohol, 
drugs or medication; do not use contraceptives; have some disease; 
inflammatory process; presenting amenorrhea; 
episode of muscle-tendon injury or joint injury in the upper, lower limbs and / or column."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-2bn2z4	Effects of two physiotherapeutic interventions in women with loss of urine following stroke	Recruiting	Intervention	2018-12-11	<NULL>	<NULL>	3079	Effects of tibial and parasacral nerve stimulation techniques in women with hyperactive neurogenic bladder after stroke.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-06	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-2bn2z4	<NULL>	The inclusion criteria of the patients in this research are: age between 40 and 70 years; carriers of ischemic or hemorrhagic stroke; who has more than one month post AVC with overactive bladder; without infection in the urinary tract and bladder tumor, without cognitive deficit (mini-mental&gt; 18).	The criteria for excluding patients in this research are pregnant women, women who already had urinary incontinence before the stroke episode, women who have pacemaker implantation and taking neurogenic bladder medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-7cb9yc	Effects of two physiotherapy approaches in patients with low back pain	recruiting	Intervention	2011-11-06	<NULL>	<NULL>	158	Immediate effects of specific or inespecific spinal manipulation in patients with chronic low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-07	Universidade Cidade de São Paulo	Bandagens Plus	https://ensaiosclinicos.gov.br/rg/RBR-7cb9yc	<NULL>	We will include patients who will be seeking care for chronic low back pain as well as patients with chronic low back pain from the community with a pain intensity level of at least 3 points on a 0-10 Pain Numerical Rating Scale.	Patients with any contra-indication for manual therapy will be excluded (i.e. lumbar stenosis, spinal fractures, cancer, acute infections, lumbar osteoporosis, acute rheumatic conditions, any bleeding diseases, spinal tuberculosis, and deep venous trombosis).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-10c2zysn	Effects of Two Pilates Method Exercise Protocols on the Treatment of Gestational Lumbopelvic Pain: A Randomized Controlled Trial	Not yet recruiting	Intervention	2026-01-29	<NULL>	<NULL>	8812	Effects of Two Pilates Method Exercise Protocols on the Treatment of Gestational Lumbopelvic Pain: A Randomized Controlled Trial	<NULL>	n/a, n/a, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia – FAEFI/UFU	<NULL>	<NULL>	<NULL>	Pregnant women aged between 18 and 40 years; gestational age between 20 weeks and 0 days and 24 weeks and 6 days at the time of recruitment; clinical diagnosis of lumbopelvic pain with onset in the current pregnancy; pain score equal to or greater than 3 on the 11-point Numerical Rating Scale regarding the last week; presence of clinically relevant functional disability defined by the Roland-Morris Disability Questionnaire with a score equal to or greater than 14; presentation of formal medical clearance from the obstetrician for physical exercise; agreement to participate in the research by signing the Informed Consent Form	Pregnant women with bone deformities ; presence of any other condition causing lumbopelvic pain, such as herniated disc, previous lumbar surgery, and ankylosing spondylitis ; presence of major muscle dysfunctions ; neurological or cognitive impairments that prevent understanding of the proposed procedures ; volunteers visibly under the influence of drugs or alcohol ; current physical injury or medical condition that prevents exercise, such as heart conditions, hypertension, diabetes requiring insulin, kidney disease, cancer, and severe asthma ; conditions that increase the risk of illness, such as epilepsy requiring pharmacotherapy and hyperemesis gravidarum ; regular practice of Pilates, Yoga, or core strengthening in the six months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-3jjbs2	Effects of two placements on the behavior of preterm infants.	Recruitment completed	Intervention	2018-09-14	<NULL>	<NULL>	2198	Effects of positioning on dorsal and right lateral decubitus on behavioral and physiological indicators of preterm newborns.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-14	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3jjbs2	<NULL>	"Pre-term with post-conceptual age on the day of intervention between 32 and 36 weeks and 6 days;
Of both sexes;
Postnatal age&gt; 24 hours;
Clinically stable (free of intravenous access, in ambient air and oral feeding, by nasogastric or orogastric tube;
In the case of twins, only one was chosen by lot."	"They presented neurological impairment (hydrocephalus, microcephaly, periventricular hemorrhage grades III and IV and brachial plexus lesion;
With congenital malformation (myelomeningocele, encephalocele, agenesias and focomelias, among others);
With suspicion of some kind of genetic alteration;
With sensorial alterations (visual and auditory);
With orthopedic alterations;
With viral, bacterial or congenital infections;
With an Apgar score equal to or less than 4, at 5 minutes, suggestive of choking;
Or whose mothers abused toxic substances during pregnancy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-3g38dx	Effects of two sessions of Physical Training on the genetic means in women aged 50 to 70 years	Recruiting	Intervention	2018-05-15	<NULL>	<NULL>	1793	Global Screening of Genetic and Epigenetic factors sssociated with magnitude of response to different Physical Training in women 50-70 Years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3g38dx	<NULL>	Woman aged 60 and over 70 and present medical clearance certificate for physical exercise	To reach a score below the cut-off point in the cognitive performance assessment performed by the Montreal Cognitive Asessment; to be diagnosed with some neurological disease and to present auditory, visual and motor deficits; to be currently smokers and / or in the last six months and to consume caffeine in the last 24 hours before the collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-6cvprm	Effects of two training programs: aerobic and resistance in muscle strength, physical fitness and muscle pain in participants with blood pressure, abdominal obesity, cholesterol and glucose levels impairments	Recruiting	Intervention	2016-01-12	<NULL>	<NULL>	679	Effects of two periodized training programs: aerobic interval and resistance training in isokinetic strength, physical fitness and clinical parameters on Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6cvprm	<NULL>	Sedentary men; between 35 and 60 years; diagnosed with Metabolic Syndrome	use of drugs or medications, except those used to control the risk factors of Metabolic Syndrome; presenting amenorrhea; inflammation and or infection; episode of muscle tendon or osteo articular injury in the upper, lower limbs and or spine in the last three months; respiratory diseases; neurological disorders and cardiovascular disease at high risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-6bgqk4	Effects of two treatment techniques over the length and width step people with Parkinson&apos;s disease	Recruitment completed	Intervention	2016-02-25	<NULL>	<NULL>	719	Effect of two differents intervention programs on kinematic parameters of gait in patients with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-02	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6bgqk4	<NULL>	will be included Male and female; with a diagnosis of idiopathic Parkinson&apos;s disease; classified in stages I to III of Hoehn Yahr; with the realization of independent walking without the use of assistive devices; which do not stage pharmacological adaptation; and can perform assessments and interventions &quot;on&quot; phase of medications for Parkinson&apos;s Disease.	Will be excluded those who experience pain; fracture; or serious injury to soft tissue in the six months previous history to the study and history of cardiovascular or respiratory changes uncontrolled and cognitive changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-2typh66	Effects of two types of associated brain stimulation to improve unilateral spatial neglect after stroke	Not yet recruiting	Intervention	2023-10-24	<NULL>	<NULL>	6533	Effect of Transcranial Magnetic Stimulation by Theta Burst Modality as a Priming Effect to Transcranial Direct Current Stimulation in Unilateral Spatial Neglect after Stroke: TITAN TRIAL	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Departamento de Clinica Médica	Departamento de Clinica Médica	https://ensaiosclinicos.gov.br/rg/RBR-2typh66	<NULL>	Individuals of both sexes, aged 18 to 85 years, with a diagnosis of ischemic stroke in the subacute phase (7 days to 3 months from the onset of symptoms, due to lesions of the right virus, confirmed by tomography CT and or magnetic resonance imaging (MRI) and unilateral spatial neglect diagnosed by checking less than 129 on the Behavior Intention Test - BIT	Individuals with any metal in the head segment, skin lesions in the electrode placement area, clinical instability, severe cognitive impairment, global aphasia, visual disturbances prior to stroke, hemorrhagic stroke, previous Rankin bigger then 1, bilateral lesions, pacemaker, epilepsy, severe CHF or unstable conditions that may pose a risk to the participant, concurrent diagnosis of rapidly deteriorating illness (eg, terminal cancer), participating in studies involving medications or other interventions, pregnancy, or other associated neurological conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-9wrq8n7	Effects of two types of Exercise on Breast Cncer	Not yet recruiting	Intervention	2025-03-31	<NULL>	<NULL>	7870	Acute effects of Exercise performed in two shorter sessions versus one longer session over the course of a day on Plasma Myokines, Growth and Viability of Mammary Carcinoma Lineage Cells: a Clinical, Randomized and Crossover Study with patients with Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Hospital Imaculada Conceição	https://ensaiosclinicos.gov.br/rg/RBR-9wrq8n7	<NULL>	Woman; over 18 years of age; breast cancer patient undergoing radiotherapy; able to perform physical exercise according to medical evaluation	Have severe cardiovascular, metabolic or osteoarticular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-3pvdvfk	Effects of two types of exercise on shoulder pain, function and muscular control in individuals with shoulder tendinitis	Recruiting	Intervention	2023-05-10	<NULL>	<NULL>	6066	Isometric versus isotonic exercise in individuals with rotator cuff tendinopathy - effects on shoulder pain, function, and neuromuscular control: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3pvdvfk	<NULL>	individuals aged between 18 and 60 years, with shoulder pain for at least three months; at least one positive specific test in physical exam (Jobe test or resisted external rotation); and diagnosed with tendinopathy by an orthopedist through confirmed morphological alterations in the rotator cuff tendons (supraspinatus and/or infraspinatus) observed using nuclear magnetic resonance or ultrasonography	individuals that perform high-intensity sports with high shoulder demand; impaired long head of biceps; adhesive capsulitis; history of glenohumeral luxation or subluxation; history of clavicle, scapula, or humerus fracture; history of rotator cuff surgical intervention; signs of partial or complete rupture of  rotator cuff; acromioclavicular joint osteoarthritis; neurologic or rheumatologic dysfunctions; corticoid application at least three months before the baseline evaluation; body mass index&gt;28 kg/m2 since it may compromise quality of electromyography data; and individuals under treatment with fluoroquinolone antibiotics or diabetes because both may affect tendon metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-36fvws	Effects of two types of respiratory muscle training on respiratory strength in bypass patients	Recruitment completed	Intervention	2020-01-07	<NULL>	<NULL>	3340	Effects of two types of Inspiratory Muscle Training on respiratory strength in patients undergoing Myocardial Revascularization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Faculdade Nobre	Instituto Nobre de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-36fvws	<NULL>	Using as inclusion criteria an individual of both sexes, aged 18 years or older and submitted to myocardial revascularization procedure via median sternotomy and cardiopulmonary bypass.	Exclusion criteria were patients who did not understand how to perform the techniques, who had hemodynamic instability during the assessment of maximal inspiratory pressure, who had some physical limitation that made it difficult to perform the devices, which remain in the Intensive Care Unit (ICU) for more than 4 days, those who require Invasive Mechanical Ventilation for more than 24 hours and who do not accept to sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4hqbmf	Effects of two types of weight training: traditional and blood flow restriction on the strength, power, muscle mass and performance in daily activities in the elderly	Data analysis completed	Intervention	2016-04-04	<NULL>	<NULL>	785	Effects of two types of weight training: conventional and partial restriction of blood flow on the muscle strength and power, muscle quality and functional performance in elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-30	Universidade Federal da Paraíba	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-4hqbmf	<NULL>	"Ages from 55 years; show complete functional independence; be physically active; not perform strength training in the last six months; not have the disease:
arthritis, arthritis, neuropathy, chronic obstructive pulmonary disease; not present cardiac arrhythmias; deep vein thrombosis; not having suffered myocardial infarction within 6 months prior to the intervention period; not reporting muscle or joint injury in the lower limbs; do not use heart pacemaker; submit ankle brachial index situated between 0.90 and 1.40; speed normal pulse wave; Normal central systolic pressure."	Do not get minimum frequency of 75% to the training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-59z6n59	Effects of two water-based exercise programs on health parameters in adults with Type 2 Diabetes	Recruiting	Intervention	2023-07-05	<NULL>	<NULL>	6204	Effects of different volumes of water-based combined training on health parameters in adults with Type 2 Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-59z6n59	<NULL>	Men and women with type 2 diabetes mellitus; aged between 40 and 65 years; who are undergoing medical treatment using oral hypoglycemic agents and/or insulin; who are not practicing systematic physical exercise in the three months prior to the study	Uncontrolled hypertension; autonomic neuropathy; severe peripheral neuropathy; proliferative diabetic retinopathy; severe non-proliferative diabetic retinopathy; uncompensated heart failure; peripheral amputations; chronic renal failure; body mass index (BMI) &gt; 45.0 kg/m2; individuals who experienced severe symptoms of COVID-19 in the previous 12 months (resulting in hospitalization); any muscle or joint impairment that prevents the performance of physical exercises safely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-8ghcx3	Effects of Type II Collagen Association on Muscle Strength in Pain and Function of Patients with Knee Arthrosis	Recruitment completed	Intervention	2019-07-08	<NULL>	<NULL>	2807	Effects of the combination of the non-denatured collagen type II (UC-II®) and the Russian current muscle reinforcement on the pain and function of patients with osteoarthritis of the knee: a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-8ghcx3	<NULL>	Men and women 40 to 75 years of age (this age group is justified because it covers the subjects with the stage of evolution of osteoarthritis of degree I to III); Unilateral and bilateral knee osteoarthritisfor more than three months with classification I to III in the radiological classification of Kelgren Lawrence confirmed by orthopedic doctor; Functional score of Lequesne higher than 4.5; Availability of dedication to treatment during the study period (six months); Patient agrees not to initiate any new physical or drug therapy for knee OA during the study period; Have signed the Term of Free and Informed Consent.	Grade IV knee osteoarthritis in the Kellgren-Lawrence radiological classification confirmed by orthopedist; Non-ambulatory; History of inflammatory arthropathy, septic arthritis, rheumatoid arthritis, inflammatory joint disease, uric acid gout, joint fracture, fibromyalgia, collagen genetic disease; Neurological diseases leading to cognitive deficits; History of asthma or type I or II diabetes; Psychiatric disorders; Symptomatic heart disease; Patients with clinical manifestations that do not allow the accomplishment of exercises; Presence of a skin or other type of skin disease at the level of the thigh; Urinary incontinence; Pregnancy; Alcoholism; Cancer; Patients with previous history of joint infiltration of corticoid or viscossuplementation in the knee in the last three months; History of trauma or knee surgery in the last six months; Three consecutive absences not justified physical rehabilitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-2pr7zp	Effects of unmetabolized folic acid on DNA modifications, messenger RNA expression and in the function of blood NK cells in individuals who consume folic acid in fortified flours or as a vitamin supplement.	Data analysis completed	Intervention	2017-03-27	<NULL>	<NULL>	1192	Effects of unmetabolized folic acid on global DNA methylation, mRNA expression and NK cells citotoxicity in individuals exposed to mandatory fortification with folic acid and/or therapeutic use of this vitamin	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2pr7zp	<NULL>	Healthy subjects; both sexes; aged between 18 and 45 years.	Individuals under 18 years, chronic alcoholics; patients with acute or chronic diseases; pregnant women; users of immunosuppressive medications, vitamins or vitamin supplements; blood donors in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-5hm62q	Effects of Unripe Banana Flour on blood tests and anthropometric data on Overweight and Visceral Fat subjects	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1550	Evaluation of the effects of regular consumption of Unripe Banana Flour on the metabolic and anthropometric parameters of Overweight Individuals and Visceral Adiposity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5hm62q	<NULL>	Women between the ages of 20 and 50; Body mass index greater than or equal to 25 kg / m² and less than 40 kg / m²; Waist circumference greater than or equal to 80 cm; Not having participated in a weight loss program in the last six months; Be healthy.	Cigarette smoker volunteers; history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; being pregnant or nursing; practice restrictive diets; allergic reactions to any of the components of the shake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-87pw366	Effects of upper and lower limb exercises on patients after COVID-19.	Recruiting	Intervention	2022-03-29	<NULL>	<NULL>	5315	Effects of a post-Covid-19 cardiopulmonary rehabilitation protocol: a clinical trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-20	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-87pw366	<NULL>	Both genders; 18 years of age or older; confirmed diagnosis of COVID-19 by RT PCR test; have a computed tomography scan of the chest.	Participants who develop any disabling condition for participation in the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-7wgtqnz	Effects of use with crocheted Octopus or Swaddled on the Sleep Quality of Premature Newborns	Recruitment completed	Intervention	2022-09-30	<NULL>	<NULL>	5643	Effects of positioning with the Octopus or Swaddled on the sleep of Very Low Birth Weight Newborns	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade federal do Rio Grande do Norte	Universidade federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7wgtqnz	<NULL>	Premature newborns who present weight of birth greater than 1500 grams; with APGAR ≥ 5 in the fifth minute; no evidence of perinatal asphyxia or neurological disease; absence of maternal drugs and antiepileptics drugs or antidepressants during the last month of pregnancy; absence of child use of a drug antiepileptic or analgesic in the last 24 hours; no malformations; clinically stable; in room air	Need treatment with theophylline, sedatives, muscle relaxants or analgesic medications; return for respiratory support or oxygen therapy; discharge before the evaluation of the second method	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-775d8m	Effects of using a Cell Phone Application while quitting smoking and satisfying participants of an existing Program	Not yet recruiting	Intervention	2019-06-26	<NULL>	<NULL>	2787	Effect of the use of a mobile application on smoking cessation and satisfaction of participants in a Specialized Program	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2019-06-18	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-775d8m	<NULL>	Smoking patients; in the age group between 25 and 70 years.	Patients with severe psychic comorbidities;illiterate; who are not available to attend face-to-face meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-7fzzkb7	Effects of using a vibratory device to help babies with Bronchiolitis	Recruiting	Intervention	2025-11-14	<NULL>	<NULL>	8506	Effects of Expector® LAC use in infants with Acute Viral Bronchiolitis: a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-23	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Infants; both sexes; diagnosed with Acute viral bronchiolitis; hospitalized in a healthcare facility; parents or legal guardians must be at least 18 years old and must authorize the participation of the minors as well as their own by signing the Informed Consent Form	Infants with congenital musculoskeletal abnormalities in the thoracic region such as Kyphoscoliosis; presence of pre-existing cardiorespiratory disorders such as congenital heart diseases and Cystic fibrosis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:28
RBR-5xcqs47	Effects of using an Ankle Binding Technique to gain flexion of the dorsum of the foot range of motion and dynamic ankle balance: a randomized controlled trial	Recruiting	Intervention	2023-06-05	<NULL>	<NULL>	6134	Effectiveness of self-application of a Talar Stabilizing Taping on dorsifflexion range of motion and dynamic stability of the ankle in crossfit practitioners: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-06	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Maynart Sports Center	https://ensaiosclinicos.gov.br/rg/RBR-5xcqs47	<NULL>	The sample will be composed of individuals who practice CrossFit; of both sexes; who report being practitioners of the sport for a minimum of 3 months with a weekly frequency of more than 2 days.	Individuals who report a history of ankle sprain in the last 6 weeks will be excluded; individuals with limited range of motion due to edema identified through the cacifo&apos;s test and measurement of ankle circumference compared to the contralateral ankle; individuals with range of motion limitation due to reported pain; individuals reporting vestibular dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-22ctkjq	Effects of using cell phone applications with and without therapeutic supervision on the ability to perform day-to-day activities in older adults	Recruitment completed	Intervention	2021-12-08	<NULL>	<NULL>	6349	Functional capacity of older people before and after the practice of physical activity performed through smartphone exercise applications with and without therapeutic supervision	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-01-30	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-22ctkjq	<NULL>	Healthy volunteers; aged between 60 and 80 years; both sexes; sedentary; independent to perform activities of daily living; vaccinated against COVID-19.	Volunteers with cognitive impairment; presence of injuries, fractures or amputations of lower limbs; presence of neurological, vestibular or cardiovascular diseases; participating in other activity programs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-5f426rx	Effects of using Colchicine for the prevention of inflammatory complications, arrhythmias and pain control in the postoperative period of cardiac surgery.	Data analysis completed	Intervention	2022-07-06	<NULL>	<NULL>	5470	Effects of Colchicine in the prevention of Post-pericardiotomy syndrome, pain control and occurrence of Atrial Fibrillation in the postoperative period of Cardiac Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade de Santa Cruz do Sul	Universidade de Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5f426rx	<NULL>	Patients in post operative of cardiac surgery; both sexes; age 18 to 85 years.	Patients undergoing emergency cardiac surgery; presence of atrial fibrillation in the preoperative period; use of pacemakers; patients with chronic renal failure; patients undergoing treatment for endocarditis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-4mx7jx	Effects of using Nintendo Wii® video game in patients with Parkinson&apos;s disease to study upper limb function	Recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1157	Study of non-immersive virtual reality in patients with Parkinson&apos;s disease: funcional analysis in upper extremities	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-15	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	Associação Fluminense de Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-4mx7jx	<NULL>	Individuals must be between 60 and 70 years old of both genders.To present a diagnosis of Parkinson&apos;s disease classified in stages 2, 2,5 and 3 of the modified scale of Hoehn and Yahr , obtaining more than 13 points in the Mini-Mental State Examination (MMSE) For illiterate, 18 points for low or medium education and 26 for education above 9 years, be able to copy the pentagon and must be without physiotherapy treatment for at least 3 months prior to the training program.	Patients with other neurological and musculoskeletal conditions limiting upper limb function; Unstable heart disease or cardiorespiratory failure; Patients with cognitive limitations who fail to respond to questionnaires and obey verbal and visual commands; Resting heart rate greater than 120 bpm; Systolic blood pressure greater than 180 mmHg and diastolic blood pressure greater than 100 mmHg; Patients whose medication or dose is modified during the training protocol; Patients using a pacemaker or electronic biological device according to the manufacturer of the Nintendo Wii ™.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-48hdw55	Effects of using pneumatic compression boot on muscle recovery after running downhill	Recruitment completed	Intervention	2023-09-15	<NULL>	<NULL>	6436	Effects caused by the use of pneumatic compression boots on performance indicators muscle recovery after running downhill: Randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-48hdw55	<NULL>	People from 18 years to 30 years old; men; physically active; without comorbidities; available to participate in all stages of the research.	Individuals who have a history of musculoskeletal injuries in the lower limbs or who make; impossible to carry out the actions proposed in the study; who have cardiovascular diseases and hypertension; who have not used caffeine 2 hours before the evaluation will not participate in the study; who will not sign the consent form of the search.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-5rsrbk6	Effects of using virtual reality on children and young people with disabilities	Recruiting	Intervention	2022-02-17	<NULL>	<NULL>	5225	Effects of an intervention protocol using virtual reality in children and young people with Sensorimotor Alterations	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5rsrbk6	<NULL>	Children and young people with sensorimotor disorders; ages from 10 years old	Participants unable to understand and execute the specific instructions and commands of the intervention will be excluded; non-adaptation to the proposed intervention protocol; in case of two absences and non-attendance of the online sessions without justificatio; those who present a technical failure in the technological devices preventing the protocol from being carried out	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-7thswq	Effects of Vagus Nerve Electric Stimulation  upon the autonomic nervous system, cardiac function and inflammation in patients with the Metabolic Syndrome	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	3339	Effects of Vagus Nerve Transcutaneous Electric Stimulation on autonomic, hemodynamic and inflammatory markers in patients with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Universidade Nove de Julho-UNINOVE	Universidade Nove de Julho-UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7thswq	<NULL>	"Elected individuals met all the criteria listed below:
Diagnosis of Metabolic Syndrome based on newly established criteria - three abnormal findings out of five qualify a person for the diagnosis of Metabolic Syndrome:
Waist circumferential increase ( equal to or greater than 102cm in men; equal to or greater than 88cm in women);
Increased triglycerides (equal to or higher 150 mg/dL);
Reduced HDL-C (equal to or less than 40mg/dL in men; equal to or less than 50mg/dL in women);
Increased blood pressure (systolic equal to or higher 130mmHg); and/or diastolic equal to or higher 85mm Hg);
High fasting blood glucose (equal to or higher 100mg / dL);
Patient declaration of stable weight and diet for at least six months until study entry;
Normal renal function;
Normal thyroid function;
Able to declare written consent and compliance with study taxation along the study."	"Subjects were not eligible to participate in the study if they met any of the exclusion criteria listed below:
On antidiabetic medication or with HbA1c greater than 8.0%;
Triglyceride levels equal or greater than 400mg / dL or on lipid-lowering medication;
Serum alanine transaminase (AST) and / or aspartate transaminase (ALT) levels higher than 200U / L;
Resting systolic pressure greater than or equal to 160 mm Hg; resting diastolic pressure greater than or equal to 100 mm Hg;
Using antihypertensive drugs that interfere (beta blockers) with HRV;
History of debilitating chronic diseases;
Pregnancy;
Volunteers presenting any active neoplasm; cutaneous lesion and / or sensitivity deficit of the left auricle; being on radiotherapy and / or chemotherapy and immunosuppressive treatment, patients with chronic infectious diseases (including hepatitis, Acquired Immunodeficiency Syndrome)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7z8tzjf	Effects of Vestibular Stimulation through Positioning in Hammocks on the development of the premature baby compared to Motor Physiotherapy	Recruiting	Intervention	2022-05-10	<NULL>	<NULL>	5384	Effects of Vestibular Sensory Stimulation through Balanced Net Positioning in late Preterm Infants on neuromotor development compared to Conventional Therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-03	Universidade Federal do Triangulo Mineiro	Universidade Federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7z8tzjf	<NULL>	late preterm infants (born between 34 to 36 weeks and 6 days of gestational age); neonatal period; (newborns up to 29 days of life); hemodynamic stability; Apgar score at 1&apos; and 5&apos; above 7 points; minimum weight of 1100 grams; spontaneous breathing.	non-adaptation to treatment or that presents one or more of the following characteristics: cardiac or neurological diseases, osteopenia of prematurity and are receiving anticonvulsant, sedative or analgesic medication during the intervention or under phototherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-738wng	Effects of vibrations generated in oscillating / vibratory Platform in young and Healthy individuals	Recruiting	Intervention	2018-09-03	<NULL>	<NULL>	2166	Evaluation of the acute effects of vibrations generated in oscillating / vibratory Platform in young and Healthy individuals through functional parameters	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-738wng	<NULL>	Individuals over 18 years of age, both sexes, healthy	diagnosis of osteo-myocardial diseases; neurological disease that causes &quot;fear&quot; of the movements on the oscillating platform; clinical disease; at the discretion of the investigator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-277fqv	Effects of Video Game Games on Breathing and Balance of Parkinson&apos;s patients	Data analysis completed	Intervention	2018-04-13	<NULL>	<NULL>	1710	Effects of Physical Training with Exergames on the Respiratory Function and on the Balance of Individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-277fqv	<NULL>	Subjects with moderate stages of Parkinson&apos;s disease; both genders; autonomy to perform the exercises; identified through the Mini Mental Status Examination	The smokers; who presented an uncorrected visual deficit; associated respiratory, cardiac or neurological disease; who had changes in Parkinson&apos;s disease medication (dopaminergic) during the study; three consecutive days of physical training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-7gr6js	Effects of video game therapy in the management of gait in chronic post-stroke individuals	Data analysis completed	Intervention	2017-08-02	<NULL>	<NULL>	1329	Effects of virtual reality therapy in the treatment of gait in chronic hemiparetic individuals after ischemic stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-09	Universidade de Araraquara (UNIARA)	Universidade de Araraquara (UNIARA)	https://ensaiosclinicos.gov.br/rg/RBR-7gr6js	<NULL>	Inclusion criteria were the occurrence of stroke episode (single, unilateral, ischemic) at least 6 months before the beginning of the study, minimum score in the Mental State Mini Exam according to the volunteer&apos;s level of education and in the item &quot; &quot;(2 points) of the Admissional Scale. In addition, maintenance of standing posture was necessary without support or use of a walking aid for one minute according to item 2 of the Berg scale.	Exclusion criteria for a presence of cardiovascular diseases; cognitive or communication deficiencies that preclude a procedure exercise; antecedents of joint or muscular injuries in the lower limbs (fractures, dislocations or surgery and generalized ligament laxity).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-2vt6tx	Effects of video games on functional capacity, quality of life and molecular data of elderly people living in long-term care facilities	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4182	The impact of gametherapy on clinical-functional outcomes, quality of life and biomarkers in peripheral blood of institutionalized elderly	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Centro Universitário Metodista-IPA	Centro Universitário Metodista-IPA	https://ensaiosclinicos.gov.br/rg/RBR-2vt6tx	<NULL>	To be 60 years or older; be residing at the research site.	Use lower limb prostheses; neuropaths with motor deficit; be undergoing chemotherapy or hemodialysis; bedridden elderly; cognitive deficit; use drugs containing HDAC inhibitor; inability to communicate; not having medical clearance to perform physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-33yz6xw	Effects of Video Games on the health of older adults	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8340	Effects of Active Video Games on the health of older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora, campus Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-33yz6xw	<NULL>	Individuals aged 60 years or older; of both sexes	Participants who have a medical diagnosis of psychological disorders (T.), for example: Social phobia; Bipolar disorder; Autism spectrum disorder (ASD); Personality disorder; Psychotic disorder; and Panic disorder. Neurodegenerative diseases, for example: Alzheimer&apos;s; Dementia; Parkinson&apos;s; Down syndrome; Multiple sclerosis; Autoimmune rheumatic disease; Hydrocephalus; Epilepsy; and Alcohol and/or illicit drug abuse. Cardiometabolic diseases, for example: Diabetes mellitus (type 1); Coronary artery disease; Stroke; and Chronic kidney disease. Lung diseases, for example: Chronic obstructive pulmonary disease; Pneumonia; Tuberculosis; and Bronchitis. Presenting symptoms suggestive of cardiovascular disease, such as: Syncope; Dyspnea; Tachycardia; and Angina. Presenting symptoms suggestive of neurodegenerative diseases, such as: persistent memory loss of recent events or important information; deficits in speech fluency or sentence construction; difficulty solving everyday problems or making simple decisions; difficulty recognizing people, objects, or places; irritability or aggression without apparent cause; difficulty performing simple motor tasks; loss of coordination and balance without apparent cause. Continuous use of psychotropic medications, such as antidepressants, anxiolytics, mood stabilizers, and/or stimulants, for a period of less than three months, an interval considered necessary for the body to adapt and minimize the initial effects of these medications. Introducing, throughout the intervention protocol, complementary therapies not initially planned, such as psychological and/or psychiatric interventions; use of medications that may influence the outcomes of interest; and the practice of physical or digital exercises that may impact the variables analyzed. Possess psychological or cognitive limitations; and/or osteoarticular conditions that prevent the practice of physical activity (PA) and/or medical impediment to the practice of PA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-78yqfn	Effects of virtual games to activate the brain and well-being of individuals with spinal cord injury	Recruitment completed	Intervention	2020-03-30	<NULL>	<NULL>	3683	"Effects of virtual reality, brain activation and perception of the well-being of
individuals with spinal cord injury"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade de Franca	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-78yqfn	<NULL>	"Experimental Group: participants of both sexes; age between 20 to 60 years; diagnosis
clinical picture of complete and / or incomplete spinal cord injury; minimum injury time of one year; etiology of traumatic injury; sedentary. Control group: participants of both sexes; age between 20 to 60 years; without any type of disability; sedentary."	"Experiment Group: participants with significant orthopedic impairments that could limit sitting posture (such as severe contractures or cutaneous lesions on the lower limbs); present devices for spinal stabilization that limits mobility; osteoporosis; uncontrolled cardiovascular instability; neurological disorders other than spinal cord injury (for example, stroke); Disease
Alzheimer&apos;s; Vascular Dementia; Mixed Dementia; Lewy Bodies Dementia; Frontotemporal dementia; clinical diagnosis of depression; use of antidepressant drugs and cognitive impairment. Control group: participants with significant orthopedic damage that could limit sitting posture (such as severe contractures or cutaneous lesions on the lower limbs); present devices for spinal stabilization that limits mobility; osteoporosis; uncontrolled cardiovascular instability; neurological disorders other than spinal cord injury (for example, stroke); Disease Alzheimer&apos;s; Vascular Dementia; Mixed Dementia; Lewy Bodies Dementia; Frontotemporal dementia; clinical diagnosis of depression; use of antidepressant drugs and cognitive impairment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-8dv3kg	Effects of virtual reality based exercise on mental and physical health of elderly resident in long-term care facility	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3072	Effects of virtual reality based exercises on mental health, physical performance, muscular quality, inflammatory profile and cerebral activity of elderly resident in long-term care facility: double-blind, randomized, controled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal Fluminense	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-8dv3kg	<NULL>	To be elderly long-term care facility resident. To have preserved comunication capacity	Have a history of severe heart disease without medical release to perform physical exertion. To present acute musculoskeletal injuries that make it impossible to perform the exercises. To present severe sequelae of cerebrovascular accident or advanced neurodegenerative diseases. To present impossibility of applying the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-9cnvv46	Effects of Virtual Reality on children and young people with sensory and motor problems	Not yet recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8194	Effects of an intervention protocol using Virtual Reality in children and young people with sensory-motor changes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	https://ensaiosclinicos.gov.br/rg/RBR-9cnvv46	<NULL>	Children and young people with sensorimotor disorders; will be included in the study; of both sexes; aged from 10 years to 17 years 11 months and 29 days	Participants unable to understand will be excluded; execute intervention-specific instructions and commands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-9zbk7y	Effects of virtual reality on the balance and mobility of elderly people living in nursing homes	Recruitment completed	Intervention	2017-01-26	<NULL>	<NULL>	1172	Comparison of balance and mobility in postgraduate institutionalized elderly with virtual rehabilitation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-11	Faculdade de Filosofia e Ciencias- UNESP Marilia	Faculdade de Filosofia e Ciencias- UNESP Marilia	https://ensaiosclinicos.gov.br/rg/RBR-9zbk7y	<NULL>	Elderly people of both sexes; Institutionalized; Aged 65 or over; Good health condition; Good visual acuity or corrected visual acuity; Do not use polypharmacy, especially anti-hypnotics and antidepressants; It is a condition for the elderly to be able to stand without resting feet.	Elderly people over 85 years or younger than 65; With osteoarticular diseases; With neurological diseases; Elderly people who can not stand erect without support and / or with united feet; With hearing loss greater than 70%; Reduced visual acuity without correction; Making use of polypharmacy, including antidepressant and hypnotics; Hypotension	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-39srtp	Effects of vitamin D3 supplementation on oxidative and inflammatory stress markers in overweight or obese workers	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3905	Effects of vitamin D3 supplementation on inflammation and oxidative stress markers in overweight and obese women: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-39srtp	<NULL>	women aged between 18 and 59 years; have vitamin D deficiency or insufficiency; have a Body Mass index greater than 25 kg / m²; do not take any vitamin D supplementation; not taking anticonvulsants or medications to treat the human immunodeficiency virus or acquired immunodeficiency syndrome; not having a diagnosis of Type I Diabetes Mellitus, nephrotic syndrome, acute or chronic kidney disease, liver disease, hypothyroidism, hyperthyroidism, history of stroke or acute myocardial infarction in the last 6 months; do not drink alcoholic beverages; do not smoke	Women with previous vitamin D use; women under 18 or over 59; women using anticonvulsants or medications to treat the human immunodeficiency virus or acquired immunodeficiency syndrome; women diagnosed with Type I Diabetes Mellitus, nephrotic syndrome, acute or chronic kidney disease, liver disease, hypothyroidism, hyperthyroidism, history of stroke or acute myocardial infarction in the last 6 months; Alcoholic women; smoking women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-4ws3sb5	Effects of Vitamins B in Adult	Recruiting	Intervention	2024-04-25	<NULL>	<NULL>	6968	Evaluation of the Effects of Vitamins B on Adult Research Participants	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2023-02-06	Loema -  Instituto de Pesquisa Clínica e Consultores SS Ltda	Loema -  Instituto de Pesquisa Clínica e Consultores SS Ltda	https://ensaiosclinicos.gov.br/rg/RBR-4ws3sb5	<NULL>	Participants of both sexes; aged between 18 and 65 years; who have the capacity to understand and agree to participate in the study, indicating by signing the Free and Informed Consent Form approved by the Research Ethics Committee System; and agreeing to comply with the planned study procedures and to attend the visits; will be included in the study must be vitamin B12 deficient (serum cobalamin dosage &lt; 300 pg/mL), good health, determined by the absence of significant findings in medical history, physical examination, laboratory tests (biochemistry, hematology, and urinalysis), measurement of vital signs, and electrocardiogram results; participants who do not have reproductive potential should be checked for their current condition, such as: postmenopausal women (defined as 12 months or more of amenorrhea), hysterectomized women, oophorectomized women (bilateral) and/or have undergone tubal ligation (tubal ligation); the female participants must have childbearing potential who present a negative pregnancy test result on the day of administration of the first dose of the drugs of the study, as well as throughout the clinical trial; and agree on the use of safe contraception	Participants who have any clinical condition that, at the discretion of the investigator, may compromise participation in the study, and/or have difficulty swallowing solid medications; have a diagnosis of pernicious anemia or documented or suspected hemoglobinopathies; have a diagnosis of gastrointestinal disease that compromises the absorption of vitamin B12 administered orally (atrophic gastritis or Crohn&apos;s disease); have undergone bariatric surgery (partial or complete gastrectomy, or gastric reduction surgery); have undergone ileal resection or pancreaticopancreatical; have a documented or suspected diagnosis of pancreatic disease; or have undergone pancreatectomy; have undergone oral treatment with vitamin B12 (mecobalamin, hydroxycobalamin or cyanocobalamin) and/or multivitamins containing vitamin B12 in the last 30 days; or have been treated with injectable formulations containing vitamin B12 in the last 3 months; have chronic liver disease (documented or suspected) or current laboratory abnormality of liver enzymes; have chronic kidney injury requiring dialysis; have a history of myeloproliferative diseases or other neoplastic/metastatic diseases in the last 5 years; use levodopa, phenobarbital, phenytoin, primidone, pyrimethamine, valproic acid, hydantoin, aminosalicylates, aminoglycosides, colchicine, potassium in extended-release formulation, mesalazine, ascorbic acid, antibiotics, nitrates, fluorouracil, chloramphenicol, proton inhibitors, metformin, and biotin (vitamin B7); have a history of alcoholism (average alcohol intake of more than 3 drinks of alcoholic beverages in one day or more than 7 drinks of alcoholic beverages per week, for women, and more than 4 drinks of alcoholic beverages in one day or more than 14 drinks of alcoholic beverages per week, for men); or having ingested alcoholic beverages in the last week prior to the start of treatment; have a folate deficiency and/or having an iron deficiency; if the participant is pregnant, breastfeeding and/or intends to become pregnant during the study period; have hypersensitivity or contraindication to use of study drugs or chemically related compounds; have participated in clinical studies in the past twelve (12) months, unless there may be direct benefit to the research participant, at the discretion of the investigator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-843pth	Effects of Vitamins&apos; Supplementation on strength gains following Physical Training in Breast Cancer survivors	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2683	Effects of antioxidant supplementation on strength training-induced neuromuscular adaptations in breast cancer survivors	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-18	Centro Universitário de Brasília - UniCEUB	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-843pth	<NULL>	"The sample of the present study will be comprised of 40 survivors of breast cancer referred to the chemotherapeutic, radiotherapeutic and / or surgical treatment in the public and / or private hospital network. 
Must be female;
Have been diagnosed with stage I to IIIC breast cancer (1, 3);
Have completed radiotherapy and / or chemotherapy for at least six months; 
Have not been involved in exercise programs for at least six months."	"Metastatic cancer;
Cardiovascular and/or metabolic/ and/or muscular dysfunctions;
Secondary cancers"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-9hvj4tb	Effects of vocal technique with Acapella on Singers	Recruiting	Intervention	2024-03-12	<NULL>	<NULL>	6848	Immediate effects of Sounded High Frequency Oral Oscillation Technique in singers	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9hvj4tb	<NULL>	being a popular singer of popular genres; like pop; stone; hip hop; R&amp;B; country; MPB;countryside; Gospel; from the city of Itabirito; be active in singing for at least 3 years; be between 18 and 50 years old	being an opera singer; be in speech therapy; have an infection or allergy that affects the upper airways on the day of collection; not being able to perform the technique; self-declare a disease of cardiovascular origin; neurological; pulmonary; cleft lips and/or palate; facial or rib fractures; be a smoker or have a diagnosis of laryngeal disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-6dgn572	Effects of Vocal Warm-Up with and without the use of Shaker® in singers	Recruiting	Intervention	2024-03-05	<NULL>	<NULL>	6830	Immediate effects of Vocal Warm-up with and without the use of a Voiced Oral High-frequency Oscillation Device on singers	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6dgn572	<NULL>	Women choristers active in Belo Horizonte choirs; between 18 and 55 years old; with more than 1 year of choir experience	Smoking choristers; with self-reported vocal complaints; during menstrual period; self-report of disease of cardiovascular origin, hormonal, neurological disease; presence of cleft lips or palate; facial or rib fractures; diagnosed with dysphonia; with vocal complaints; with hearing complaints; diagnosed with hearing loss; with upper airway infection at the time of evaluation; singers in speech therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-5g4g9bq	Effects of walking training in individuals with stroke	Data analysis completed	Intervention	2023-12-12	<NULL>	<NULL>	6652	Effect of total walking volume on functional mobility, gait, and cardiovascular risk in individuals with chronic stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Associação das Pioneiras Sociais	Associação das Pioneiras Sociais	https://ensaiosclinicos.gov.br/rg/RBR-5g4g9bq	<NULL>	Medical diagnosis of a stroke that occurred at least 6 months ago and no participation in physical training or rehabilitation programs during the study period.	Inability to walk at least 10 meters without assistance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-9qg3bg	Effects of water aerobics on body measurements, fat percentage, quality of life, postural balance and daily activities in the elderly	Data analysis completed	Intervention	2017-09-28	<NULL>	<NULL>	1407	Influence of a Balance development program on elderly community residents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal Fluminense	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9qg3bg	<NULL>	Non-participants of any regular physical activity program in the six months prior to the survey.	Elderly people with disabilities that impair the body balance, as blindness or uncorrected visual impairment, and/or hearing impairment. Parkinson&apos;s, Alzheimer&apos;s or dementia diagnosed by a doctor. Lower limb prostheses. Against medical indication for exercising. Cognitive impairment detected by the Mini Mental (score below 24).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-48z4vp	Effects of Water Therapy on risk of falls in older people	Not yet recruiting	Intervention	2019-07-03	<NULL>	<NULL>	3930	Effects of Aquatic Physical Exercise on falls and risk factors in community-dwelling older people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-19	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-48z4vp	<NULL>	Ability to walk alone; reported initial availability of attending the training twice a week; not being engaged for five or more times per week in one or more of the activities walking, running, cycling, swimming, aerobic exercise, dancing, gardening or weight lifting.	Any cardiovascular or infectious disease present in the list of the absolute contraindications described in the Physical Activity Readiness Medical Examination; score in the Mental State Mini-exam below the cut-off point designated by level of schooling minus one standard deviation; to present a motor sequelae of stroke and neurological diseases that interfere with cognition or mobility; urinary incontinence; open wounds; sensitivity to chemicals used in swimming pool; severe and uncorrected audiovisual disturbance that makes communication difficult during the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4g2w8sc	Effects of Water-Based Exercises and Nutritional Guidance on Body Composition and Physical Performance of Older Women with Knee Osteoarthritis	Terminated	Intervention	2022-04-25	<NULL>	<NULL>	5360	Effects of Water-Based Exercises and Nutritional Guidance on Body Composition and Functionality of Older Women with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-02	Centro Universitário Unidombosco	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4g2w8sc	<NULL>	Women at least 65 years old diagnosed with uni ou bilateral knee osteoarhritis grade I - IV  (KELLGREN; LAWRENCE, 1957). Were able to walk independently without orthosis and/or auxiliary devices.	The participants with (a) prostheses in any lower limb joint; lower limb surgery in the last 12 months; (b) insulin-dependent; (c) or restrictive conditions to physical activities were excluded. In addition, participants engaged in any other regular training programs in the six months that preceded the study were not included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-3fkv888	Effects of water-based therapy on balance, mobility, motor function and behavior in children with Autism: a randomized clinical trial	Not yet recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9071	Effects of adding water-based therapy to land-based psychomotor rehabilitation in children with Autism Spectrum Disorder on balance, mobility, motor function and behavior: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-04	Universidade Federal da Bahia	<NULL>	<NULL>	<NULL>	The study will include children aged 5 to 10 years; who have a diagnosis of Autism Spectrum Disorder made by a specialized medical professional; who are at support level 1 or level 2; who are regularly undergoing psychomotor rehabilitation; whose parents or legal guardians consent to participation in the study.	Individuals with fear of water immersion; those who exhibit aggressive behavior; those who are participating in other aquatic activities (such as swimming) at the time of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-2rhxcc8	Effects of Weight Training and Running on Obese adolescents	Recruitment completed	Intervention	2024-07-29	<NULL>	<NULL>	7161	Effects of Strength and Competitive Training protocols on Metabolic Syndrome Indicators in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade José Rosário Vellano Unifenas	Universidade José Rosário Vellano Unifenas	https://ensaiosclinicos.gov.br/rg/RBR-2rhxcc8	<NULL>	Overweight or obese individuals; aged between 12 and 19 years; of both sexes; sedentary individuals; agreeing to take part in the study and signing an informed consent form; not undergoing any type of treatment for metabolic diseases or using drugs or procedures that could compromise the analysis; not having been diagnosed with thyroid or endocrine/genetic diseases	Individuals who have orthopedic and cardiovascular limitations to physical practice; individuals who exercise regularly; individuals who do not comply with the researcher&apos;s requests for prior collection procedures; individuals who miss the scheduled dates for blood collection and physical assessments; individuals who miss two consecutive weeks of training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-6bgkv44	Effects of weight training over a 16-week period on the aging of the immune system in older adults with Pre-Frailty.	Recruitment completed	Intervention	2026-01-20	<NULL>	<NULL>	8775	Effects of a 16-week strength training protocol on plasma levels of immunosenescence markers and myokines in longitudinally followed pre-frail older adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-07	Universidade Federal de Ouro Preto (Campus Morro do Cruzeiro)	<NULL>	<NULL>	<NULL>	Being female; age range between 60 and 70 years; untrained in strength training; identified as pre-frail; vaccinated against COVID-19; independent in traveling to the intervention location and without permanent or temporary disability to walk; presenting neurological and/or cognitive conditions that allow them to answer the questionnaire (perceived by the interviewer during the presentation of the research and invitation to participate); free from any musculoskeletal injury; who have not undergone surgery in the last 12 months and who are not in physiotherapy treatment.	Women who experienced physical or general health problems prior to or after the start of the intervention; severe flu, respiratory tract infection, muscle and/or joint pain that could limit the performance of the exercises; those who refused to donate biological material (blood); and those who voluntarily or did not appear at the collection sites on the scheduled day and time.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-5zpnnt	Effects of weight training program versus aerobic training on blood values, oxLDL and body weight individuals with metabolic abnormalities	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	727	Effects of a resistance training program periodized versus aerobic interval in functional parameters, lipid and oxLDL of individuals with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Ciências e Tecnologia	Faculdade de Ciências e Tecnologia	https://ensaiosclinicos.gov.br/rg/RBR-5zpnnt	<NULL>	Having metabolic syndrome; not having practiced regular physical activity or have performed strength training in the last six months.	Make use of drugs or medicines; present amenorrhea; presence of inflammation and / or infection process; episode muscle tendon or osteoarticular lesions in the upper and lower limbs and / or spine; respiratory diseases, neurological and cardiovascular risk or high.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-3r92s4x	Effects of weight training, walking, and HIIT on health outcomes of sedentary women who are overweight or obese	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4969	Effects of weight training, walking and high intensity interval training on body composition, anthropometric measures, lipid profile, quality of life and other outcomes in sedentary women with overweight or obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP/USP)	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP/USP)	https://ensaiosclinicos.gov.br/rg/RBR-3r92s4x	<NULL>	Sedentary women, i.e., who have not practiced any type of physical exercise in the last 12 months for a period longer than 30 minutes per week; living in Uberaba, MG; aged between 35 and 45 years; BMI above 25 kg/m2; answering &quot;no&quot; to all items of the Physical Activity Readiness Questionnaire (PAR-Q); ability to walk without the aid of any devices	Current use of appetite suppressing or appetite-stimulating drugs; chronic conditions such as hypertension, diabetes, asthma, COPD; current smoking; being pregnant; weight loss or gain of more than 10% in the last six months, for any reason; treatment for cancer; any other conditions not provided for in the present study protocol that, in the opinion of the investigators, would adversely affect the conduct of the study and/or the safety of the participant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-796g9q	Effects of weightlifting and aerobic training on bofy fat and laboratory blood tests in adolescents with overweight and obesity	Data analysis completed	Intervention	2016-05-20	<NULL>	<NULL>	854	Effect of resistance and aerobic training program on body composition, lipid profile and high sensitive c-reactive protein of overweight and obese adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade do Estado do Rio Grande do Norte	Centro Municipal de Controle à Obesidade Jansen Jefferson Diógenes e Medeiros	https://ensaiosclinicos.gov.br/rg/RBR-796g9q	<NULL>	Adolescents of both sexes; aged between 12 and 15 years old; being overweight and obesity according to the cutoff points proposed by the World Health Organization; no history of previous experience with resistance exercises or systematic program of aerobic exercises	Attest use of tobacco, alcohol or other drugs; present some limitation that prevents the execution of any exercise; pregnancy; present endocrineisease; be making chronic drug use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-4mb9xb	Effects of whey protein associated with stimulation of anterior thigh muscles after anterior cruciate ligament reconstruction surgery	Recruiting	Intervention	2018-05-10	<NULL>	<NULL>	1775	Effects of whey protein associated with the neuromuscular electrical stimulation of the femoral quadríceps after reconstruction of the anterior cruciante ligament	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4mb9xb	<NULL>	Individuals with unilateral rupture of the Anterior Cruciate Ligament verified arthroscopically or by magnetic resonance imaging and who will undergo Anterior Cruciate Ligament reconstruction surgery	Patients with a history of renal disease; lactose intolerance; diabetes; history of surgery or contralateral knee dysfunction; any dysfunction or surgery in the hips; ankles or feet and for both groups; any neurological, cardiovascular; metabolic; rheumatic or vestibular disease; presence of cardiovascular or respiratory disease that impedes the performance of the study movements and patients who refuse to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-2q8255	"Effects of whole body vibration on urine loss, quality of life and functioning of women with 
loss of urine: a double-blind randomized clinical trials"	Recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3597	Effects of whole body vibration on urine loss, quality of life and functioning of women with urinary incontinence: a double-blind randomized clinical trials	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2q8255	<NULL>	women with stress urinary incontinence and who are not undergoing any other physiotherapeutic treatment for urinary loss at the time of the research.	Patients with pacemakers or cardiac implants; metallic grafts; acute urinary tract infection; epilepsy, decompensated hypertension, BMI above 40 kg / m2; with a physical disability that unable to receive the intervention or the assessment tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-8v7rsdp	Effects of Whole-body LED on blood glucose levels in men with Type 2 Diabetes	Recruitment completed	Intervention	2025-09-22	<NULL>	<NULL>	8296	Dose-response and time-response of Whole-Body Photobiomodulation on blood glucose in men with Type II Diabetes Mellitus: a randomized, double-blind, sham-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-20	Departamento de Fisioterapia	Departamento de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-8v7rsdp	<NULL>	Study participants must be male; between 40 and 70 years old; with a low level of physical activity (according to the International Physical Activity Questionnaire (IPAQ) classification); BMI up to 34.9 kg/m² (grade I obesity); body fat percentage up to 45 mm after the sum of skinfolds; medical diagnosis of DM2 for at least 5 years; regular use of oral hypoglycemic medication for at least 6 months	Participants with fasting capillary blood glucose &gt;200 mg/dL; alcoholics; drug addicts; insulin-dependent individuals; heart patients using pacemakers; those with any cognitive deficit; neurological or pulmonary disease; and those diagnosed with any type of cancer undergoing treatment will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-82gmkbt	Effects of Whole-Body Muscle Electrostimulation associated with whey protein supplementation on physical capacities,hypertrophy, glycemia control and advanced glycation products (age) in elderly patients with Type 2 Diabetes Mellitus:triple blind randomized trial	Recruitment completed	Intervention	2025-07-07	<NULL>	<NULL>	8101	Effects of Whole-Body Electrostimulation associated with protein supplementation on physical capacities, glycemic control, and age formation in elderly Type 2 Diabetics compared to non-Diabetics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-05	Universidade São Judas Tadeu	Universidade São Judas Tadeu	https://ensaiosclinicos.gov.br/rg/RBR-82gmkbt	<NULL>	Stable dose of medication (oral antidiabetics or insulin or combination of both) for three or more months; glycated hemoglobin between 6 and 10.0%; renal function assessed by the Modification of Diet in Renal Disease (MDRD) above 60 ml/h; Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) up to 2.5 times the upper limit of the method; no impairment of the musculoskeletal system, disabling disease or previous surgeries that would prevent the exercise; no chronic non-communicable disease not adequately treated and decompensated, especially systemic arterial hypertension (SAH); does not use a pacemaker; age between 65 and 79 years; both sexes	Impossibility of carrying out evaluations and reevaluations and during the period; having more than three consecutive absences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-35w9bw	Effects of whole-body vibration on biomarkers of the elderly at different stages of sarcopenia	Recruiting	Intervention	2019-12-09	<NULL>	<NULL>	3261	Effect of the stimulation of the whole body vibration in parameters neuroendocrine-inflammatory and redox status of elderly people in different stages of sarcopenia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-15	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-35w9bw	<NULL>	Persons of both sexes aged 60 years and over; Postmenopausal women; Have not participated in any physical training program in the three months prior to the beginning of the assessments; Do not have acute illness that prevents the carrying out of the assessments; have a chronic disease, it is controlled, not being on immunosuppressive and / or anti-inflammatory medication, not presenting symptoms suggestive of cognitive impairment, according to the Mini-Mental State Examination.	Presence of epilepsy; gallstones; kidney stones; neuromuscular and neurodegenerative diseases; stroke/strokes; serious heart disease or those who have an implant; by-pass or stent; and refusal to sign the Informed Consent Term.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8sw5g4	Effects of Wrist Splint on arm Function and Symptoms in individuals with Carpal Tunnel Syndrome	Recruiting	Intervention	2020-02-19	<NULL>	<NULL>	6345	Effects of Wrist Orthosis on upper extremity Muscle Coordination, Function and Symptoms in individuals with Carpal Tunnel Syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8sw5g4	<NULL>	"Inclusion Criteria for the STC Group: Individuals aged 18-65 years, BMI 18.5 and &lt;25Kg, STC assessed by a physical therapist (strength muscle, range of motion and orthopedic tests) and medical diagnosis and/or electroneuromyography exam; CTS symptoms present for at least six months; absence of shoulder tendinopathy; active range of motion of shoulder flexion and abduction of 120 dregrees, flexion of elbow of 100 degrees, and wrist extension of 30 degrees; and positive results for the Phalen and Tinel tests.
Control Group Inclusion Criteria: Individuals aged 18-65 years; BMI 18.5 and &lt;25Kg, without subjective reports of pain in the cervical spine and upper extremity, absence of tendinopathy or previous treatment in the shoulder, elbow, wrist and hand of the dominant upper extremity."	Exclusion Criteria (both groups): Musculoskeletal disorders in the shoulder; history of trauma or previous surgery to the upper extremity or trunk; subluxation of the acromioclavicular or glenohumeral joint; diagnosis of rheumatic, degenerative or neurological disease; partial or complete tear of the rotator cuff or any other shoulder muscles; use of orthoses in the last three months; physiotherapeutic treatment or occupational therapy in the last three months; positive sign for at least two orthopedic tests for shoulder injury (Neer, Hawkins, painful arch 60º-120º, Jobe, Rowe and Speed tests)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-6vk2vjr	Effects of Yoga in the treatment of Breast Cancer: a randomized clinical trial	Recruiting	Intervention	2023-12-08	<NULL>	<NULL>	6639	Effects of Yoga practice on cancer-related fatigue of patients undergoing primary treatment for Breast Cancer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-6vk2vjr	<NULL>	To participate in the sample, participants must meet the following eligibility criteria: age equal to or greater than 18 years; diagnosis of stage I-III breast cancer; undergoing chemotherapy or radiotherapy; if you are undergoing radiotherapy treatment, you have already completed chemotherapy treatment; not present a history of severe cardiovascular disease that prevents the practice of physical exercise (with the exception of arterial hypertension controlled by medication); no active metastatic or locoregional disease; not have any severe physical or psychiatric condition that makes it impossible to exercise and not be engaged in regular exercise programs for more than 75 minutes a week.	Be under the age of 18; have already completed Primary treatment for breast cancer; presenting active metastatic or locoregional disease; have a severe physical or psychiatric condition that makes it impossible to exercise, be engaged in regular physical exercise programs for more than 75 minutes a week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-2gv5c2	Effects of yoga on different health markers	Data analysis completed	Intervention	2019-11-18	<NULL>	<NULL>	3199	Effects of yoga on heart rate variability, electroencephalogram, quality of life, salivary cortisol and functional neuroimaging by magnetic resonance in healthy adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2gv5c2	<NULL>	Healthy volunteers; both genders; age between 18 and 40 years; no experience with Bhastrika Pranayama	Diagnosis of heart problems; chronic rhinitis; frequent use of aspiration bronchodilator; regular use of beta blocker or stimulant and any drug that interferes with cardiac modulation; diagnosis of neurological or psychiatric disorders; pregnancy; metallic implants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-6yysksv	Effects of Yoga on the lives of caregivers of children with Autism in Acre	Not yet recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8562	Yoga as an Intervention in the Quality of Life and Emotional States of caregivers of children with Autism Spectrum Disorder in Acre	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal do Acre	<NULL>	<NULL>	<NULL>	Caregivers of any gender; aged 18 years or older; whose children (here considered to be between 2 and 14 years old) are diagnosed with Autism Spectrum Disorder using the classification indicated by ICD-10 with a medical report dated at least six months prior; receiving regular care at the care facility for at least six months; the caregiver must serve as the primary caregiver	Presence of health conditions, both physical and mental, that impair the individual&apos;s ability to complete questionnaires or respond to interviews independently will be considered an exclusion criterion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:22
RBR-7bcnk6h	Effects of Yoga on university students with symptoms of Anxiety and Depression	Recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6331	Effects of a Yoga program on oxidative stress, postural balance and quality of life of university students with symptoms of Anxiety and Depression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-7bcnk6h	<NULL>	Be a higher education student aged 18 or over; both genders; score 10 points or more on the Generalized Anxiety Disorder 7 (GAD-7) questionnaire that assesses symptoms of anxiety and/or 10 points or more on the Patient Health Questionnaire-9 (PHQ-9) that assesses symptoms of depression	Students with an increased risk of suicide detected by the Patient Health Questionnaire-9 (PHQ-9), and these students will be referred to the university&apos;s customer service; students with cognitive and/or physical (motor, visual and auditory) limitations that make it impossible to perform yoga practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-7rgyfvs	Effects of Yoga practice on the health of schoolchildren	Data analysis completed	Intervention	2020-12-08	<NULL>	<NULL>	4403	Effects of Yoga practice on the health of schoolchildren with a focus on elementary school I: randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-16	Escola de Artes, Ciências e Humanidades - EACH/USP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7rgyfvs	<NULL>	Children from 7 to 11 years old; students of public school; belonging to Elementary School I; living in the periphery of the city and of both sexes.	Children with a psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-10p7b8qx	Effects of Yoga techniques on the functioning of the heart and brain in older adults	Recruitment completed	Intervention	2026-04-21	<NULL>	<NULL>	9124	Effects of Yoga techniques on autonomic regulation and executive functions in independent older adults	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Age greater than or equal to 60 years; both sexes; independent and without recent yoga practice; physically active according to the international physical activity questionnaire; preserved cognitive function as assessed by the mini-mental state examination; absence of severe diseases or uncontrolled psychiatric disorders; signed informed consent form	younger than 60 years; dependent in activities of daily living; with recent yoga practice; physically inactive according to the international physical activity questionnaire; with impaired cognitive function as assessed by the mini-mental state examination; with severe diseases or uncontrolled psychiatric disorders; absence of a signed informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-2fjdnt	Effects of Yoga Thai massage and conventional stretching in women with low back pain	Recruitment completed	Intervention	2020-04-02	<NULL>	<NULL>	3699	Comparative study of Yoga Thai massage effects and conventional stretching in women with low back pain: controlled clinical trial, randomized and blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-13	Instituto Federal do Paraná	Instituto Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2fjdnt	<NULL>	"Women between 20 and 40 years old;
They must have complaints of nonspecific low back pain for more than 1 month;
Do not practice any physical activity that favors the improvement of low back pain and / or flexibility (yoga, pilates, stretching classes);
Accept to be part of the research by signing the free and informed consent form."	"Have lower back pain for less than 1 month;
Have any diagnosis of degenerative pathology in the lumbar spine/hip;
Previous previous surgeries: such as hip prosthesis, fixation of vertebrae by means of metal plates and screws;
Present sciatic nerve irradiation evaluated by Lasègue test
Present associated pathologies, such as: inflammatory processes of the bursa and tendons;
Have a congenital diseases;
Having uncontrolled hypertension and thyroid disorders;
Be pregnant;
Diagnosis of neoplastic pathology."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-83xh37	Effects of Ziclague® (Alpinia zerumbet) in patients with hereditary spastic paraplegia	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2157	Ziclague® (Alpinia zerumbet) in patients with hereditary spastic paraplegia: randomized, double-blind, placebo-controlled and crossover clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Estadual de Campinas (UNICAMP)	Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-83xh37	<NULL>	Age between 18 and 80 years old. Clinical diagnosis of Hereditary Spastic Paraplegia. Ability to walk out of home. Assistive devices are permitted	Wheelchair bound patients. Additional neurological symptoms that may significantly impact gait such as ataxia, lower motor neuron disease, polyneuropathy, mental retardation or dementia. Fixed tendon contractures. Current botulinum toxin injection or in the last six months. Pregnants or breastfeeding. Refusal to consent form. Skin infection or inflammation at site of interest.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-9jmw7k3	Effects of β-alanine supplementation on performance and recovery in Crossfit practitioners	Not yet recruiting	Intervention	2022-01-21	<NULL>	<NULL>	5158	Effects of chronic β-alanine supplementation on physical performance and recovery in Crossfit practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9jmw7k3	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 40 years; Crossfit® practitioners who train in the most advanced category of the modality, in which they perform the movements and training loads as prescribed by the trainer (category RX) for at least 3 months.	Vegetarian or vegan volunteers; with use of anti-inflammatory drugs; with the use of anabolic steroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4fgknb	Effects on blood pressure of conventional strength training, handgrip training and combined training (strength training + handgrip training)	Recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3255	Cardiovascular Effects of Dynamic, Isometric and Combined (Dynamic + Isometric) Resistance Training in Hypertension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-4fgknb	<NULL>	Men between 30 and 65 years old; with diagnosis of hypertension and under antihypertensive medication with drug and dose maintained at least in then previous 4 months; not taking anti-hypertensive drugs that directly affect cardiac autonomic regulation (such as beta-blockers and non-dihydropyridine calcium channels inhibitors); not practicing physical exercise more than twice a week or more than 150 minutes/week; no resistance exercise practice in the previous 6 months.	Presence of secondary hypertension and/or target-organ lesion; systolic/diastolic blood pressures equal to or greater than 160/105 mmHg; obesity level II or superior; other cardiovascular diseases besides hypertension; diabetes with complications or in use of insulin; presence of osteoarticular diseases that limit resistance exercise execution; electrocardiographic alterations during maximal exercise  test that suggest cardiovascular diseases; change in dose or medication during the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-5b6wc3	Effects on breathing, muscles, metabolism and body awareness in Pilates exercises	Recruiting	Intervention	2019-12-26	<NULL>	<NULL>	3302	Respiratory, muscular, metabolic effects and body perception of a Pilates protocol: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-12	Universidade Federal de Alfenas - Unidade II	Clínica Vital Pilates	https://ensaiosclinicos.gov.br/rg/RBR-5b6wc3	<NULL>	Healthy individuals; age range between 18 and 44 years old; women; willing to participate in the study.	Severe pathologies of the spine; fibromyalgia; intellectual disability; inability to provide consistent information; practice of PM until 6 months before the study; pregnancy; puerperium up to 6 months; vestibular disorders that may interfere with balance; use of continuous medication for pain or inflammation; obesity greater than 30 kg / cm2; be conducting other fitness programs; practice of functional physical activity; neurological diseases; cardiovascular diseases; severe respiratory diseases; any other condition in which exercise is contraindicated; who do not agree to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-79q47nj	Effects on pain reduction of the use of Ibuprofen/Oxycodone versus Ibuprofen/Acetominophen in lower wisdom tooth Extraction Surgery: a comparative study	Recruiting	Intervention	2022-08-15	<NULL>	<NULL>	5553	Analgesic effects of the use of Ibuprofen/Oxycodone versus Ibuprofen/Acetominophen  in lower third molar Extraction Surgery: a comparative study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-04-11	Universidade Estadual do Rio de Janeiro	Universidade Estadual do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-79q47nj	<NULL>	ASA I, according to American Society of Anesthesiology (ASA) criteria; with the need for bilateral extraction of lower third molars; dental elements that present similarity of positioning; Class 1 and 2 impacted teeth and A and B by Pell and Gregory classifications; non-smokers	History of pericoronitis in the lower third molar region; cystic lesion involving the lower third molar; allergy to any medication prescribed in the postoperative period; any systemic or autoimmune disease; use of other concomitant medications; pregnant patients; lactose intolerant or allergic; surgeries exceeding 40 minutes in duration; smokers volunteers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-8w55n2g	Effects on postural control using Galvanic vestibular stimulation in spinal cord injury patients	Recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6347	Galvanic vestibular stimulation in spinal cord injury: effects on postural control	<NULL>	0, non-randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2023-06-05	Universidade Metodista de São Paulo - UMESP	Universidade Metodista de São Paulo - UMESP	https://ensaiosclinicos.gov.br/rg/RBR-8w55n2g	<NULL>	Having a sensory motor sequelae such as tetraparesis/tetraplegia or paraparesis/paraplegia secondary to spinal cord injury; being older than 18 years old; both genders; being under medical follow-up for their condition; following the prescribed medical guidelines	Having  some non-compensated clinical condition; having a pressure ulcer; having a metallic implant in the skull; having seizure episodes, and having a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-3g8vv3k	Effects on posture and movement after Non-Invasive Neuromodulation in Spinal Cord Injury	Recruiting	Intervention	2025-02-21	<NULL>	<NULL>	7782	Galvanic Vestibular Stimulation in Spinal Cord Injury: effects on motor control	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Universidade Municipal de São Caetano do Sul	Universidade Municipal de São Caetano do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3g8vv3k	<NULL>	Having sensorimotor sequelae such as tetraparesis/tetraplegia or paraparesis/paraplegia secondary to spinal cord trauma; being over 18 years old; both sexes; being under medical supervision for their condition; and following the prescribed medical guidelines	Having any non-compensated clinical alteration; having a pressure ulcer; having a metal implant in the skull; having episodes of seizure; having a pacemaker or other type of neuromodulator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-9m95rx	Effects on the heart, blood vessels, and psychological and social aspects following three types of bodybuilding training in men with high blood pressure	Data analysis completed	Intervention	2018-01-30	<NULL>	<NULL>	1603	Association of cardiovascular and functional effects of different methods of resistance training with psychosocial aspects of men with high blood pressure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-15	Universidade Federal do vale do São Francisco	Universidade Federal do vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-9m95rx	<NULL>	Be resident in the cities of Petrolina / PE or Juazeiro / BA; present age between 40 and 60 years; be sedentary; (ABPM) with mean values of 24h, wakefulness or sleep greater than 125, or 110 mmHg, respectively in the systolic BP or greater than 75, or 70 mmHg, respectively in the diastolic BP, which characterizes the individual with BP elevated according to VI Brazilian Guidelines on Hypertension (2010); body mass index above 25 kg / m².	The BP, although elevated as highlighted in the previous item, should be controlled during resting measures performed in a laboratory environment, being lower than 160 and 105 mmHg for systolic and diastolic BP, respectively; to present systemic hypertension diagnosed; presenting cardiometabolic diseases or dysfunctions in the health history, such as musculoskeletal limitations, that may compromise physical integrity and participation in the study, mainly diseases of the cardiovascular system; make use of some type of drug related to blood pressure control during the study participation, if they use for other purposes inform the researcher; the maintenance of the proposed training frequency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-9fxqs2	Effects on the muscles after the use of the vaginal dilator in pregnant	Data analysis completed	Intervention	2017-07-10	<NULL>	<NULL>	1286	Muscle responses after the physiotherapeutic intervention with the use of the vaginal dilator in pregnant women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9fxqs2	<NULL>	"Age between 18 and 35 years;
Gestational age of 34 weeks;
Primparas;
Physiological gestation;
With medical authorization to perform the physiotherapeutic intervention."	"Multiple gestation;
Presence of high gestational risk;
Presence of bone deformities;
Presence of important muscular dysfunctions;
Unusual fetal position or risks that make vaginal delivery impossible (placenta previa);
Presence of risk of ascending infection such as vaginal infection (such as premature amniorrhexis, vaginal infection);
Presence of unhealed lesions in the vaginal region;
Be visibly under the influence of drugs or alcohol;
Presence of vaginal bleeding;
Presence of cervical cancer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-6d3mxjw	Effects over time of arm therapy for children with cerebral palsy	Data analysis completed	Intervention	2024-06-03	<NULL>	<NULL>	7039	Long-term effects of constraint-induced movement therapy in the hemiparetic upper limb use in children with cerebral palsy between two and ten years of age	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-06	Departamento de Fisioterapia da Universidade Federal de São Carlos	Departamento de Fisioterapia da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6d3mxjw	<NULL>	Have a diagnosis of hemiplegic cerebral palsy; gross motor function level one to three; manual function level one to three; score on the pediatric manual upper limb scale with an average score less than two and a half	Have cognitive or visual impairment; be allergic to the cast material; have behavioral problems that compromise the application of therapy; be undertaking other intensive training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-7dvgwyr	Effects physical exercise on moviment, pain, memory, attention, welfare in patients with chronic pain	Recruiting	Intervention	2024-12-10	<NULL>	<NULL>	7583	Effects of physical exercise practice on motor behavior, pain intensity, cognitive and psychological aspects and quality of life in patients with chronic pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7dvgwyr	<NULL>	Be over 18 years of age; men and women; present a medical certificate to participate in evaluations and physical exercise practice; have persistent musculoskeletal pain lasting 6 months or longer; be sedentary (not engaging in 150 minutes or more of moderate aerobic activity per week); demonstrate understanding of the questionnaires, tests/scales, and instructions/guidelines during evaluations and physical exercise practice	Presenting restrictions that make it impossible to carry out assessments and practice physical exercises; present a medical diagnosis of dementia;  have symptoms of COVID-19;  not carrying out all the procedures foreseen in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-8dvnsjh	Effects to the nervous system of Passive Technique on the Chest in patients with High Blood Pressure, immediate result and after 1 week	Recruitment completed	Intervention	2021-12-03	<NULL>	<NULL>	5071	Afferent Effects of Articulatory Technique for increased Mobility of the Rib Cage in Autonomic Function in Hypertensive Patients, acute and follow up after 1 week	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-26	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-8dvnsjh	<NULL>	Be male, enjoy good systemic health, clinical diagnosis of arterial hypertension and use of medication for this, ages between 40 and 70 years.	Being female, inability to sit in a sitting position, musculoskeletal disorders, hospitalization episodes in the last 3 months, indigenous ethnicity and quilombolas, pathology acquired during the research that causes hospitalization, absence on the day of assessment and data collection, ingestion of any substance that may influence the results.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-95m34pp	Effects/Effectiveness of Training of Formal Caregivers on sedentary fifestyle and physical and cognitive function of older adults in nursing homes	Recruitment completed	Intervention	2022-08-12	<NULL>	<NULL>	5546	Effects/Effectiveness of Formal Caregiver Training on sedentary behavior and functionality of older adults in nursing homes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal do Paraná - Programa de Pós-Graduação em Educação Física	Universidade Federal do Paraná - Programa de Pós-Graduação em Educação Física	https://ensaiosclinicos.gov.br/rg/RBR-95m34pp	<NULL>	Older adults aged 60 years or over; of both sexes; living in a nursing home for three months or more; Formal caregivers working in a nursing homes; of both sexes, of all age groups; working in institutions that consent to this proposal	Individuals with changes in physical capacity due to trauma or muscle disease in a recent history; and/or rehabilitation treatment due this situation; Caregivers with service time in the role of less than 15 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-55jf6q	Efficacy and Safety Evaluation of HCPA-1 Silicone Stent in the Treatment of Central Airway Obstructions.	Recruiting	Intervention	2013-08-08	<NULL>	<NULL>	224	Efficacy and Safety Evaluation of  Silicone Stent in the Treatment of Central Airway Obstructions.	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Ministério da Saúde	Hospital de Clinica de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-55jf6q	<NULL>	Consent to participate in the study by signing (by the patient or family / legal guardian when aplicable) of the Informed Consent Form; 18 years old or more;  clinically significant stenosis (symptomatic or about to become symptomatic) in the trachea, main bronchus or intermediate bronchus, which can be treated after a stente implant.	Clinical or absolute anesthesic contraindication of the rigid bronchoscopy under general anesthesia;constitutional or acquired anatomic limitations that prevent the rigid bronchoscopy;another indication of exclusive preferential treatment modality for stenosis (surgery, radiotherapy, chemotherapy, other).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-56xh4c	Efficacy and safety evaluation of new model of  intraocular lenses for cataract surgery.	Not yet recruiting	Intervention	2019-08-27	<NULL>	<NULL>	2897	Efficiency and efficacy study of a new family of monofocal and multifocal intraocular lenses in the Cataract Personalized Solution Project.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital Evangélico de Belo Horizonte	Hospital Evangélico de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-56xh4c	<NULL>	"Patients who had a clinically documented diagnosis of age-related cataract (cortical, nuclear, sub-capsular or a combination) that was considered amenable to cataract extraction by the intracapsular facectomy method.
Adult patients 21 years of age or older.
Patients eligible for primary intraocular lens implantation.
Patients willing and able to perform clinical and follow-up examinations for a minimum of 1 year after cataract surgery.
Patients requiring intraocular lens implantation powers ranging from 10 to 30 diopters.
Patients with a visual potential of 20/40 or better in the eye indicated for intraocular lens implantation.
Patients with a corneal cylinder corrected for less than 1 diopter."	"Patients with any pathology of the anterior segment in which the intracapsular facectomy procedure with primary IOL implant is contraindicated (examples: keratoconus, dystrophy or corneal scars, anterior uveitis).
Patients with corneal inflammation or edema, including but not limited to: keratitis, keratoconjunctivitis and ceratouveitis.
Patients with uncontrolled glaucoma or glaucoma under treatment.
Patients with history of retinal detachment.
Patients with diabetic retinopathy (proliferative or non-proliferative).
Patients with congenital, metabolic, traumatic or complicated cataract.
Patients with marked microphthalmia or aniridia.
Patients who had previous ocular surgery of the proposed eye.
Patients who have already received other IOLs in the contralateral eye.
Irregular corneal astigmatism.
Amblyopia.
Clinically significant changes in the retinal / macular pigment epithelium.
Neovascularization of the iris, the camerular and retinal angle.
Severe recurrent inflammation of the anterior or posterior segment of unknown etiology.
Optical atrophy.
Patients with immunodeficiency (infectious, neoplastic or drug).
Patients on chronic systemic steroid use or immunosuppressive drugs.
Patients simultaneously participating in another clinical trial.
Patients with a strong dependence on intermediate vision, night vision, or specific occupational requirements (eg, commercial pilots and professional drivers)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-96kvrq	Efficacy and safety of corticosteroids use in severe pulmonary inflammation in children	Recruiting	Intervention	2015-03-02	<NULL>	<NULL>	409	Phase II, randomized, placebo-controlled, double-blind clinical trial to evaluate the effects and safety of infusion of low-doses of Methilprednisolone in early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) in children	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2015-02-01	Instituto D&apos;Or de Pesquisa	Instituto de Puericultura e Pediatria Martagão Gesteira - Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-96kvrq	<NULL>	Pediatric patients in mechanical ventilation; diagnosis of ALI/ARDS within the first 72 hours based on the current literature criteria; informed consent properly signed; both genders; age range from 29 days to 18 years.	ALI/ARDS with more than 72 hours of diagnosis; failure to obtain written informed consent  to participate in the study; condition requiring &gt; 0.5mg/Kg/day of prednisone equivalent; primary or secondary neuromuscular dysfunction; patients using aminoglycosides combined with neuromuscular blockers; cardiopulmonary arrest within 7 days or anytime during present hospitalization prior to enrollment; irreversible cessation of all brain function; immunosuppression acquired or congenital, including HIV+ status; history of bone marrow or solid organ transplantation; current malignancy, neutropenia, receiving cytotoxic therapy for any reason, and acute burn injury; severe chronic liver disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-93gkd4	Efficacy and safety of Eslicarbazepine Acetate (BIA 2-093) as single therapy for patients with newly diagnosed partial-onset seizures - ESL extension study	Recruiting	Intervention	2016-03-11	<NULL>	<NULL>	748	Efficacy and safety of Eslicarbazepine Acetate (BIA 2-093) as monotherapy for patients with newly diagnosed partial-onset seizures: a double-blind, randomized, active-controlled, parallel-group, multicenter clinical trial - open-label ESL extension	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2016-01-04	Instituto de Neurologia de Curitiba	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-93gkd4	<NULL>	Participation in the preceding double-blind study and still ongoing at the time of unblinding; informed consent signature; cooperation and willingness to complete all aspects of the study.	Exclusion from the double-blind study; clinical evaluation of suicidal risk; occurrence of an adverse event; events of alcohol, drug, or medication abuse; relevant clinical laboratory abnormalities; pregnancy or lactating.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-10jx5y6r	Efficacy and safety of hyaluronic acids Juvederm Volux® and Restylane Shaype® in filling the chin	Not yet recruiting	Intervention	2026-02-10	<NULL>	<NULL>	8856	Efficacy and safety of Juvederm Volux and Restylane Shaype in filling the chin region: a clinical study, randomized and double-blind	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Centro Universitário Ingá - UNINGÁ	<NULL>	<NULL>	<NULL>	Volunteers with complaint of chin retrusion, classified as levels II - III on the Galderma chin retrusion scale (GCRS); no previous aesthetic treatments in the mental region.	Volunteers who are pregnant or breastfeeding; with hypersensitivity to hyaluronic acid; who have received aesthetic treatments in the medial and lower region of the face in the last year; who present with autoimmune diseases.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-10mk5gvb	Efficacy and safety of the combined use of a bioestimulator and ultrasound for improvement of facial sagging	Not yet recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7277	Efficacy and safety of the combined use of Poly-L-lactic acid and Microfocused Ultrasound for improvement of Facial Sagging: a randomized, triple-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-15	Fernanda Almeida Nunes Castro	Angioderm Centro de Estética Ltda	https://ensaiosclinicos.gov.br/rg/RBR-10mk5gvb	<NULL>	Healthy women, 35 and 50 years old, with mild to moderate facial laxity.	facial surgical scar; history of herpes simplex infection; active or systemic infection;  non-steroidal anti-inflammatory drugs use; anticoagulants use; steroids use; heparin; vitamin K or E within the last 30 days prior to the study; pregnancy; breastfeeding; any clinical condition and or laboratory abnormality; previous aesthetic procedures with biostimulators or physical resources such as laser, radiofrequency and or ultrasound on the face in the last 3 years; injection of permanent materials in the face anytime	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-4f9tcc	Efficacy and safety study of Fluticasone Furoate/Vilanterol on the dose of 100/25 microgram (mcg) inhalation powder, Fluticasone Propionate/Salmeterol on the dose of 250/50 mcg inhalation powder and Fluticasone Propionate on the dose of 250 mcg inhalation powder in adults and adolescents with persistent asthma	Recruiting	Intervention	2016-04-29	<NULL>	<NULL>	825	A randomized, double blind, double dummy, parallel group, multicenter study of once daily Fluticasone Furoate/Vilanterol 100/25 mcg inhalation powder, twice daily Fluticasone Propionate/Salmeterol 250/50 mcg inhalation powder, and twice daily Fluticasone Propionate 250 mcg inhalation powder in the treatment of Persistent Asthma in adults and adolescents already adequately controlled on twice daily inhaled Corticosteroid and long acting beta2 Agonist	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-03-09	GlaxoSmithKline Brasil	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-4f9tcc	<NULL>	"Subjects must give their signed and dated written informed consent to participate prior to start any study activities;
Subjects must be outpatients equal or more than 12 years of age at visit 1 and diagnosed with asthma, as defined by the National Institutes of Health, for at least 12 weeks prior to visit 1;
Male and female (if eligible). An eligible female is defined as having non-childbearing potential or having childbearing potential and a negative urine pregnancy test at screening and agrees to use an acceptable method of birth control consistently and correctly;
Subjects must have a FEV of equal or more than 80% of the predicted normal value;
If they have received mid dose of inhaled corticosteroids(ICS) plus Beta-2 agonist prolonged action (LABA), equivalent to Fluticasone Propionate/Salmeterol 250/50 micrograms(mcg) twice daily or an equivalent combination via separate inhalers for at least the 12 weeks immediately preceding visit 1;
Subjects must be able to replace their current SABA treatment with albuterol/salbutamol aerosol inhaler at visit 1 for use, as needed, for the duration of the study. Subjects must be able to with hold albuterol/salbutamol for at least 6 hours prior to study visits;
If in the opinion of the investigator the subject&apos;s asthma is well controlled"	"History of life-threatening asthma, defined for this protocol as an asthma episode that required intubation and/or associated with hypercapnea, respiratory arrest or hypoxic seizures within the last 5 years;
Culture-documented or suspected bacterial or viral infection of the upper or lower respiratory tract, sinus or middle ear that is not resolved within 4 weeks of visit 1 and led to a change in asthma management or in the opinion of the investigator, expected to affect the subject&apos;s asthma status or the subject&apos;s ability to participate in the study;
Any asthma exacerbation requiring oral corticosteroids within 12 weeks of visit 1 or resulting in an overnight hospitalization requiring additional treatment for asthma within 6 months prior to visit 1;
A subject must not have current evidence of atlectasis, bronchopulmonary dysplasia, chronic bronchitis, chronic obstructive pulmonary disease, pneumonia, pneumothorax, interstitial lung disease, or any evidence of concurrent respiratory disease other than asthma;
A subject must not have any clinically significant, uncontrolled condition or disease state that, in the opinion of the investigator, would put the safety of the subject at risk through study participation or would confound the interpretation of the results if the condition/disease exacerbated during the study;
A subject must not have used any investigational drug within 30 days prior to Visit 1 or within five half-lives (t½) of the prior investigational study, whichever is longer of the two;
Any adverse reaction including immediate or delayed hypersensitivity to any beta2-agonist, sympathomimetic drug, or any intranasal, inhaled, or systemic corticosteroid therapy. Known or suspected sensitivity to the constituents of the study molecules;
History of severe milk protein allergy;
Administration of prescription or non-prescription medication that would significantly affect the course of asthma, or interact with study drug;
A subject must not be using or require the use of immunosuppressive medications during the study;
A subject will not be eligible if he/she or his/her parent or legal guardian has any infirmity, disability, disease, or geographical location which seems likely (in the opinion of the Investigator) to impair compliance with any aspect of this study protocol, including visit schedule and completion of the daily diaries;
Current tobacco smoker or has a smoking history of 10 pack-years (20 cigarettes/day for 10 years). A subject may not have used inhaled tobacco products or inhaled marijuana within the past 3 months (e.g., cigarettes, cigars, electronic cigarettes, or pipe tobacco);
A subject will not be eligible for this study if he/she is an immediate family member of the participating investigator, sub-investigator, study coordinator, or employee of the participating investigator"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-4vz9c4	Efficacy and Safety Study with 24-month Follow-up of Oleogel-S10 in Patients a group of inherited disorders that involve the formation of blisters following trivial trauma	Not yet recruiting	Intervention	2018-02-16	<NULL>	<NULL>	1642	"Double-blind, Randomised, Vehicle-controlled, Phase III, Efficacy
and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis Bullosa"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-03-01	Hospital da Criança Santo Antônio - Irmandade Santa Casa de Misericórdia de Porto Alegre	Inc Research Br Serviços de Pesquisa Clínica LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4vz9c4	<NULL>	"Male and female patients with any subtype of inherited Epidermolyse bullosa age more than 4 years; Patients with an Epidermolyse bullosa target wound; Patient and/or his/her legal representative has/have been informed, has/have read and
understood the patient information/informed consent form, and has/have given written
informed consent; Patient and/or his/her legal representative must be able and willing to follow study
procedures and instructions."	"Epidermolyse bullosa target wound with clinical signs of local infection; Use of systemic antibiotics for wound-related infections within seven days prior to enrolment; Administration of systemic or topical steroids within 30 days before enrolment; Immunosuppressive therapy or cytotoxic chemotherapy within 60 days prior to enrolment; Patient has undergone stem cell transplant or gene therapy for the treatment of inherited EB; Current and/or former malignancy; Enrolment in any interventional study or treated with any investigational drug for any
disease within 4 weeks prior to study entry; Factors present in the patient and/or his/her legal representative that could interfere with study compliance such as inability to attend scheduled study visits or compliance with
home dressing changes; Pregnant or nursing women and women of childbearing potential including postmenarchal female adolescents not willing to use an effective form of birth control
(e.g., implant, injectable, combined oral contraceptive, intrauterine contraceptive device, sexual abstinence, vasectomised partner) during participation in the study (and at least 3 months thereafter); Patient is a member of the investigational team or his/her immediate family; Patient lives in the same household as a study participant"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-9gnhth	Efficacy and sensitivity of home bleaching vs tooth whitening associated with desensitizer.	Recruitment completed	Intervention	2017-04-17	<NULL>	<NULL>	1214	Effectiveness and tooth sensitivity of at-home dental bleaching with 4% hydrogen peroxide vs associated dental bleaching with 35% and 4% hydrogen peroxide with desensitizing - randomized clinical study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9gnhth	<NULL>	Patients older than 18 years of age, male and female, with good general and oral health, teeth free of caries lesions, have teeth in color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and that they agree with the informed consent term (TCLE).	Patients who have undergone dental bleaching, who have dental prostheses or restorations in the upper anterior teeth, who are pregnant or breastfeeding, have gingival retractions, dental sensitivity, endodontic treatment in the upper anterior teeth, severe dental dimming By tetracycline, fluorosis or endodontia), non-carious cervical lesions, fixed orthodontic appliance, habits of bruxism, smoking and visible cracks in the teeth and that are making continuous use of some medication, such as analgesics and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-3pyzt5	Efficacy and tolerability of Meclin® (meclizine hydrochloride) in Acute vertigo (a type of dizziness) and other types of dizzy spells identified by Otorhinolaryngologist	Not yet recruiting	Intervention	2015-03-10	<NULL>	<NULL>	428	Eficacy and tolerability of Meclin®(Meclizine Chlorhydrate) in acute vertigo	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-03-23	Universidade Federal de São Paulo - UNIFESP/EPM	Apsen Farmacêutica S/A	https://ensaiosclinicos.gov.br/rg/RBR-3pyzt5	<NULL>	Men and Woman aged above 18 years with presence of dizziness / vertigo of vestibular origin symptons , due to peripheral vestibular disorders, with dizziness / vertigo of vestibular origin symptoms, show  moderate intensity on in  5-points Likert  scale of: absent, mild , moderate , severe and very severe, if woman, negative Beta hcg and who present normal or controlled blood pressure;	Used meclizine or dimenidrynate in 15 days; Used alcohol in 48 hours; Pregnancy or breastfeeding; Presence of vomiting which prevent the ingestion of tablets; Presence of clinical condition that determines contraindication to the active substances : convulsions , suspected intracranial compressive processes , closed-angle glaucoma , prostatic adenoma with urinary disorders , liver diseases , endocrine , renal, and / or uncontrolled cardiovascular , Parkinson&apos;s disease; Participants with bladder neck obstruction or symptomatic prostatic hyperplasia : anticholinergic effects of Meclizine may precipitate urinary retention; a known sensitivity to hydrochloride, meclizine or dimenhydrinate; Presence of malignant carcinomas or not remitted for more than 5 years;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-10vvfpcm	Efficacy and tooth sensitivity of different at-home bleaching protocols	Recruiting	Intervention	2022-09-08	<NULL>	<NULL>	5596	Efficacy and tooth sensitivity of different at-home bleaching protocols with a 10% carbamide peroxide: a randomized single-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-10vvfpcm	<NULL>	Minimum age of 18 years; good overall and oral health; anterior maxillary teeth without restorations or  carious or non-carious cervical lesions; right upper canine will be required to be A2 or darker according to the value-oriented Vita Classical shade guide (VITA Zahnfabrik, Bad Säckingen, Germany)	Dental prosthesis; visible enamel cracks; severe tooth discoloration; pregnant; lactating; patients with preexisting dental hypersensitivity; who underwent previous bleaching procedures and taking any anti-inflammatory or analgesic medicines.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-8nr8xy	Efficacy mouthwash developed with vegetable oils	Recruitment completed	Intervention	2017-12-18	<NULL>	<NULL>	1530	Clinical study of the efficacy of oral rinse-containing vegetable oils for the control of dental biofilm	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2016-10-04	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-8nr8xy	<NULL>	Be between 18 and 30 years old; both sexes; presence of at least 70% of teeth in the arches; absence of oral pathologies not related to the dental biofilm; present at least 40% of biofilm in the dental faces evidenced in the initial examination.	Smoking; pregnants; recent or current use of antibiotics and medicines that alter salivary flow; being on radiotherapy or chemotherapy; present systemic diseases that generate oral manifestations; presence of periodontal disease or active carious lesions; presence of dental calculus; make use of orthodontic appliance or occlusal plates; do not accept to signing the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-248jys	Efficacy of 4% Articaine anesthesia in the buccal region of the mandible with the Infiltrative Technique	Recruitment completed	Intervention	2019-10-22	<NULL>	<NULL>	3117	Anesthetic efficacy of 4% Articaine with 1: 100.000 Epinephrine by the Vestibular Infiltration Technique	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Estadual de Maringá - UEM	Universidade Estadual de Maringá - UEM	https://ensaiosclinicos.gov.br/rg/RBR-248jys	<NULL>	Painful symptomatology in one or more mandibular molars; symptomatic irreversible pulpitis; ASA I and ASA II patients; teeth that can be isolated and rehabilitated	Patients under 18 years of age; pregnant and lactating women; allergic to local anesthetics; using drugs that alter the pain threshold; teeth with open apex; root fracture; absence of lip numbness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-9c7pkd8	Efficacy of a Health Education Program on physical activity and food consumption in schoolchildren	Not yet recruiting	Intervention	2022-04-08	<NULL>	<NULL>	5333	Efficacy and effectiveness of a Health Education Program regarding the practice physical activity and food consumption in schoolchildren in a southern Brazilian county: a controlled community trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-06-20	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-9c7pkd8	<NULL>	All high schools in the state public network in the municipality of Rio Grande will be included in the Health Education Program; schoolchildren of both sexes aged between 14 and 17 years old and duly enrolled; first year high school students	Students who have physical and or cognitive limitations that prevent them from completing the self-administered questionnaires and performing the physical assessments will be excluded; students who are in the gestational period or who are breastfeeding; schoolchildren outside the age group of 14 to 17 years; students who do not reach a minimum attendance of fifty percent in the activities proposed by the Health Education Program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-2d9sfvj	Efficacy of a Hygiene Protocol for Patients Undergoing Maxillary Disjunction with Haas Palatal Expander	Recruiting	Intervention	2025-07-14	<NULL>	<NULL>	8127	Clinical Efficacy of a Professional Hygiene Protocol and its Impact on the Oral Microbiome of Patients Undergoing Maxillary Disjunction with Haas Palatal Expander: Randomized Controlled Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-02	Universidade Federal do Rio de Janeiro	Faculdade de Odontologia da Universidade Federal do Rio de janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2d9sfvj	<NULL>	Systemically healthy patients; mixed or permanent dentition phases; erupted upper incisors and first deciduous or permanent molars; maxillary atresia; feminine and masculine genders; 8 to 18 years old	Presence of systemic or periodontal disease; use of antibiotics or anti-inflammatories for up to six months; use of mouthwashes or antimicrobial gels for up to one month before or during treatment; smoking; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-3xdf4k	Efficacy of a multimodal exercise training associated with whole body vibration at falls  risk and quality of life in older adults	Recruiting	Intervention	2020-05-20	<NULL>	<NULL>	3852	Efficacy of Multicomponent Training associated with Whole Body Vibration on falls risk and quality of life in osteoporotic older adults : randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3xdf4k	<NULL>	The inclusion criteria are : olders adults (ages 60 -80 years)with osteoporosis (bone densitometry) ; Previously trips or falls ;  medical statement for exercise ( cardiologist) and no participating in other activities	Neurological disease; Epilepsy; Cognitive deficit; Severe visual impairment; Circulatory diseases; Amputation or use of lower limb prosthesis (MMII); History of recent fracture in lower limbs; Hernia, discopathy or severe spondylosis and neoplasia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-4njwqsw	Efficacy of a New Device to prevent Cervical Narrowing after Conization	Not yet recruiting	Intervention	2025-08-08	<NULL>	<NULL>	8193	Efficacy of an Intracervical Device (ICD) in preventing Cervical Stenosis following Type III Excisional Procedure (Conization) of the uterine cervix	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2025-09-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4njwqsw	<NULL>	Women indicated for type III excision (conization) of the uterine cervix; women aged 25 and older	Women with any history of previous excisional procedures (regardless of type or timing); pregnant women; women who become pregnant within 90 days following the excisional procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-5x936hn	Efficacy of a new intervention in the control of non-allergic Rhinitis: a randomized controlled trial	Not yet recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7026	Efficacy of cold bath as an intervention in the control of non-allergic Rhinitis: a randomized and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-03	M A Fornazieri Servicos Medicos (nome fantasia Clínica Olfact)	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-5x936hn	<NULL>	Participant aged between 18 and 55; have negative specific IgE (data from medical records) or negative Prick test (allergic skin test carried out at the Olfact Clinic); being diagnosed with non-allergic rhinitis	Have a history of allergy or hypersensitivity to budesonide; participant with a history of traumatic brain injury, due to the risk of neurological damage in association with hyposmia/anosmia; participants with acute or chronic rhinosinusitis; participant with a history of post-infectious olfactory loss; participants with neurodegenerative diseases, due to the high association with hyposmia/anosmia; participants with heart disease; participants with uncontrolled hypertension, asthma or chronic bronchitis; participants who are unable or unwilling to sign an Informed Consent Form or comply with the study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-57xtk7	Efficacy of a physical exercises protocol for legs in patients with venous chronic insufficiency	Recruiting	Intervention	2016-09-19	<NULL>	<NULL>	1006	Efficacy of a physical exercises protocol for lower limbs in patients with venous chronic insufficiency- Clinic trial randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-13	Universidade Federal do Rio Grande do Norte	Hospital Universatário Onofre Lopes- HUOL	https://ensaiosclinicos.gov.br/rg/RBR-57xtk7	<NULL>	individuals of both genders; aged between 35 to 69 years; diagnosed with Chronic Venous Insufficiency; ranked by criteria CEAP 2-6 without peripheral arterial disease associated, ankle index brachial between 1.3 and 0.9; with test ecco-doppler vascular venous	subjects who did not agree to participate in this study; who presented ulcers with a diameter greater than 4 cm or with clinical signs and / or confirmed diagnosis of infection; who are unable to attend the physiotherapy service twice a week and / or show inconsistent clinical manifestations with performing exercises such as congestive heart failure (class 3 or 4), angina, recent venous thrombosis, limiting musculoskeletal disorders or who have difficulty in understanding the activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-73s4x3	Efficacy of a physical therapy protocol of simultaneous tasks in the functions of elderly people who practice physical activity	Data analysis completed	Intervention	2020-02-26	<NULL>	<NULL>	3526	Effectiveness of a dual task physiotherapeutic protocol on the functionality of active elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal do Triângulo Mineiro	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-73s4x3	<NULL>	Volunteers aged 60 or over; with self-reported ability to walk at normal speed for 150 meters or more, without sitting or using support; physically active according to the International Physical Activity Questionnaire.	Sedentary volunteers; with severe cognitive impairment suggestive of dementia according to the Mini Mental State Examination; with significant or chronic orthopedic pain and joint deformities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-725bwg	Efficacy of a Pilates protocol for Non-specific Low Back Pain individuals	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	1639	Electromyographic assessment of the trunk muscles in individuals with Non-especific Low Back Pain submitted to a Pilates protocol	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-725bwg	<NULL>	Age between 18 and 40 years. Negative straight leg raise test. Presence of aberrant movement. Positive prone instability. Negative fear avoidance beliefs questionnaire (FABQ-W &lt;19).	Individuals with specific low back pain. Congenital malformation. Sensory or motor alterations. Individuals who do not fit the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-6p76t5x	Efficacy of a profissional use paste with PRG technology in reducing Dental Plaque in children with Molar-Incisor Hypomineralization (MIH)	Not yet recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7485	Efficacy of a prophylactic paste with PRG technology in reducing Dental Plaque index in children with Molar-Incisor Hypomineralization (MIH): an in situ and in vivo study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6p76t5x	<NULL>	Minimum age of 7 and maximum age of 17 years; both sexes; diagnosis of Molar-Incisor Hypomineralization (MIH); signature of the Informed Consent Form (ICF) by the legal guardian and the Informed Assent Form (IAF) by the participant; high biofilm accumulation and poor oral hygiene	Presence of syndromes or general health conditions that prevent a complete clinical examination; children who do not allow the procedure; use of fixed appliances or metal bands that may interfere with the clinical examination of all tooth surfaces; children who are illiterate or semi-literate; patients requiring emergency treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-9hdpq5	Efficacy of Acupuncture in improving pain, function and quality of life in patients with Masticatory Myofascial Pain	Data analysis completed	Intervention	2018-10-05	<NULL>	<NULL>	6395	Efficacy of Acupuncture in pain, Mandibular function and quality of life in patients with Myofascial Masticatory Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9hdpq5	<NULL>	Adults aged 18 to 60 years with a diagnosis of temporomandibular muscle dysfunction, masticatory myofascial pain, according to the Research Diagnostic Criteria for Temporomandibular Disorders; pain of intensity 4 or higher measured by visual analogue scale; pain for at least 3 months; possibility of attending appointments during the treatment and evaluation period	History of facial trauma; pregnancy; acuphobia; continuous use of nonsteroidal anti-inflammatory drugs, analgesics, antidepressants or muscle relaxants; intracranial, neurological and other major causes of headache disorders; other causes of orofacial pain; temporomandibular joint arthralgia; being submitted to another type of treatment for temporomandibular disorders; diagnosis of fibromyalgia; edentulism; use of complete denture; non-acceptance to voluntarily participate in the research or refusal to sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-2znphfj	Efficacy of Acupuncture in the pinna to reduce Anxiety in Primary Health Care professionals	Not yet recruiting	Intervention	2022-05-26	<NULL>	<NULL>	5406	Efficacy of Auriculotherapy to reduce Anxiety in Primary Health Care professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-06	Anny Caroline Santos Almeida	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2znphfj	<NULL>	All PHC health professionals in the city of Lagarto Sergipe. Assent to participation by means of a Free and Informed Consent Term. Have moderate or severe levels of anxiety, according to the State Trait Anxiety Inventory	Professionals with scheduled vacations during the research period. On sick leave. pregnant women Allergic to tape and micropore. Those who at the time of the study are using anxiolytics focus on the treatment of anxiety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-99m424c	Efficacy of acupuncture on quality of life, functional performance, shortness of breath, and lung function in patients with Pulmonary emphysema: randomized clinical trial	Not yet recruiting	Intervention	2022-09-01	<NULL>	<NULL>	5587	Efficacy of acupuncture on quality of life, functional performance, dyspnea and pulmonary function in patients with Chronic obstructive pulmonary disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-99m424c	<NULL>	Clinical diagnosis of COPD according to GOLD; ability to offer written authorization or indicate a person to read the Free and Informed Consent Form (ICF), with the agreement of the research participant; there will be no age limit, however individuals who are over 65 years old must have preserved cognitive function according to the Mini-Cog (individuals under 65 years old will not do the Mini-Cog); clinical stability in the month prior to the beginning of the protocol.	Patient with a previous medical diagnosis of a disease that affects the cognitive and does not allow the understanding of the questionnaires; individuals unable to perform any of the assessments; individuals who had exacerbations of the condition in the month prior to the beginning of the protocol; prior acupuncture therapy; being in a rehabilitation group or having been in the last 3 months; individuals who present an exacerbation of the clinical condition during the collection period will be excluded;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-5vc8wc2	Efficacy of adding non-invasive brain stimulation to Cognitive-Behavioral Therapy in the Treatment of Stress Symptoms Following Traumatic Experiences	Recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8786	Efficacy of Adding Non-Invasive Neuromodulation to Cognitive-Behavioral Therapy in the Treatment of Post-Traumatic Stress Symptoms	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Escola Bahiana de Medicina e Saúde Pública	<NULL>	<NULL>	<NULL>	Symptoms of Post-traumatic stress disorder (PTSD) for at least six months.	Individuals with self-reported associated disorders that may interfere with outcomes (such as panic disorder, generalized anxiety, craving, personality disorders or cognitive deficits, and suicidal ideation), participants who miss any treatment session, whether cognitive behavioral group therapy (gCBT) or vagal or magnetic stimulation, and individuals who experience adverse reactions to the treatments tested will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-74683n	Efficacy of aerobic training in individuals with Parkinson&apos;s disease	Not yet recruiting	Intervention	2019-02-26	<NULL>	<NULL>	3840	Efficacy of aerobic training in immunological and neurotrophic parameters and in clinical measures in subjects with Parkinson&apos;s disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-20	Universidade Federal de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-74683n	<NULL>	"Have clinical diagnosis of idiopathic PD according to the criteria of clinical diagnosis of the
United Kingdom Parkinsons Disease Society Brain Bank (Hughes et al., 1992);
Age above 40 years;
To be in stage 1,5 to 3 of Hoehn &amp; Yahr;
Be in use of l-dopa and clinically stable;
Being able to wander independently or with the use of auxiliary devices;
Have medical release for performing aerobic training."	"To have impairment of cognitive function according to the score of the Mini-Exam of the Mental State
(cut-off point 13 for illiterate, 18 for low and medium schooling and 26 for high
schooling);
Have intense dyskinesia that interferes with postural stability;
Have other neurological and psychiatric diseases;
To present musculoskeletal changes that make difficult the accomplishment of the exercises;
To present rheumatologic diseases that interfere in the concentration of mediators
inflammatory drugs;
Have an unstable cardiovascular condition."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-7q4dy7r	Efficacy of air injection in the stomach and the use of the patient&apos;s right lateral position in the migration of the enteral tube into the intestine	Recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4930	Analysis of the efficacy of Gastric Air Injection and the Right Lateral Decubitus position in the post-pyloric enteral tube migration: Pilot Study of a Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Escola de Enfermagem de Ribeirão Preto / Universidade do Estado de São Paulo	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7q4dy7r	<NULL>	Patients admitted to the Adult Emergency Room of the Hospital de Clínicas, Universidade Federal do Triângulo Mineiro; patients with post-pyloric enteral tube medical prescription; with the use of radiography to check the position of the enteral tube; patients aged 16 years or older	"Patients who have previously diagnosed anatomical abnormalities of the GIT (such as esophageal obstruction);
with gastric distention; with flexible polyurethane enteral tube indication, with a different caliber to 12 French; indication of enteral catheterization through fluoroscopy or endoscopy; indication of enteral tube by
gastrostomy or jejunostomy; in gestation period"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-7w9ffgr	Efficacy of Alternative Braces to maintain space after Early Loss of Primary Molars: randomized clinical trial	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7802	Efficacy of Bonded Wire Space Maintainer for Early Loss of Primary Molars: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-15	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-7w9ffgr	<NULL>	Patients aged between 4 and 9 years; of both sexes; deciduous or mixed dentition stage; early loss of at least one primary molar; and presence of teeth adjacent to the edentulous space	Those who require space recovery; cases in which the permanent successor is in the eruption stage; enamel defects; as well as those who are not willing to participate or collaborate with the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-7x2f4w	Efficacy of an ice popsicle on thirst management in the immediate postoperative period: a randomized clinical trial	Data analysis completed	Intervention	2016-05-31	<NULL>	<NULL>	878	Ice as strategy to the management of thirst in the immediate postoperative period: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-08	Universidade Estadual de Londrina	Hospital Universitário de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7x2f4w	<NULL>	Aged between 18 and 65 years; undergoing more than eight-hour fasting; expressing thirst spontaneously or stimulated with intensity greater than or equal to three;receiving opioids or anticholinergics in the transoperative period; duration of anesthesia exceeding one hour; having been approved in the assessment of the Safety Protocol for Thirst Management	Patients who had intake or swallowing restrictions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7phn8yv	Efficacy of analgesics in controlling pain associated with the insertion of a Copper or Hormone Intrauterine Device	Not yet recruiting	Intervention	2023-11-06	<NULL>	<NULL>	6564	Double-blind clinical trial, phase IV, prospective, national, single-center, randomized, to evaluate the efficacy of prophylactic administration of DEC103 compared to placebo in controlling pain associated with the insertion of a Copper Intrauterine Device (TCu380A IUD) or Intrauterine System with Levonorgestrel (LNG-IUS) 52 mg - DEC103-IV0123	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-11-13	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	https://ensaiosclin